                         SEQUENCE LISTING

<110>  RAMBAM MED-TECH LTD.
 
<120>  CELLS AND METHODS FOR IMPROVED IMMUNOTHERAPY

<130>  TRMB-P-008-PCT

<150>  62/810,438
<151>  2019-02-26

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  548
<212>  PRT
<213>  Mus musculus

<400>  1

Met Asn Glu Pro Thr Val Gln Pro Ser Arg Thr Ser Ser Ala Pro Ala 
1               5                   10                  15      


Ser Pro Ala Ser Pro Arg Gly Trp Ser Asp Phe Cys Glu Gln His Ala 
            20                  25                  30          


Ala Ala Ala Ala Arg Glu Leu Ala Arg Gln Tyr Trp Leu Phe Ala Arg 
        35                  40                  45              


Ala His Pro Gln Pro Pro Arg Ala Asp Leu Val Ser Leu Gln Phe Ala 
    50                  55                  60                  


Glu Leu Phe Gln Arg His Phe Cys Arg Glu Val Arg Glu Ser Leu Ala 
65                  70                  75                  80  


Gly Pro Pro Gly His Asp Tyr Arg Ala Thr Ala Pro Pro Arg Pro Ala 
                85                  90                  95      


Leu Pro Lys Ala Arg Ser Ser Glu Asp Leu Gly Pro Arg Pro Ala Cys 
            100                 105                 110         


Ala Leu Gln His Leu Arg Arg Gly Leu Arg Gln Leu Phe Arg Arg Arg 
        115                 120                 125             


Ser Ala Gly Glu Leu Pro Gly Ala Thr Ser Asp Thr Asn Asp Ile Asp 
    130                 135                 140                 


Thr Thr Ala Ala Ser Arg Pro Gly Pro Ala Arg Lys Leu Leu Pro Trp 
145                 150                 155                 160 


Gly Leu Arg Glu Pro Pro Thr Glu Ala Leu Lys Glu Val Val Leu Arg 
                165                 170                 175     


Tyr Ser Leu Ala Asp Glu Ala Ala Met Asp Ser Gly Ala Arg Trp Gln 
            180                 185                 190         


Arg Gly Arg Leu Val Leu Arg Ser Pro Gly Pro Gly His Ser His Phe 
        195                 200                 205             


Leu Gln Leu Phe Asp Pro Pro Lys Ser Ser Lys Pro Lys Leu Gln Glu 
    210                 215                 220                 


Ala Cys Ser Ser Ile Arg Glu Val Arg Pro Cys Thr Arg Leu Glu Met 
225                 230                 235                 240 


Pro Asp Asn Leu Tyr Thr Phe Val Leu Lys Val Gln Asp Gln Thr Asp 
                245                 250                 255     


Ile Ile Phe Glu Val Gly Asp Glu Gln Gln Leu Asn Ser Trp Leu Ala 
            260                 265                 270         


Glu Leu Arg Ala Ser Thr Gly Leu Gly Leu Glu His Pro Asp Thr Glu 
        275                 280                 285             


Leu Pro Leu Ser Leu Ala Ala Glu Pro Gly Pro Ala Arg Ser Pro Arg 
    290                 295                 300                 


Gly Ser Thr Asp Ser Leu Asp Gln Gly Ala Ser Pro Gly Val Leu Leu 
305                 310                 315                 320 


Asp Pro Ala Cys Gln Lys Thr Asp His Phe Leu Ser Cys Tyr Pro Trp 
                325                 330                 335     


Phe His Gly Pro Ile Ser Arg Val Arg Ala Ala Gln Leu Val Gln Leu 
            340                 345                 350         


Gln Gly Pro Asp Ala His Gly Val Phe Leu Val Arg Gln Ser Glu Ser 
        355                 360                 365             


Arg Arg Gly Glu Tyr Val Leu Thr Phe Asn Leu Gln Gly Arg Ala Lys 
    370                 375                 380                 


His Leu Arg Leu Val Leu Thr Glu Arg Gly Gln Cys Arg Val Gln His 
385                 390                 395                 400 


Leu His Phe Pro Ser Val Val Asp Met Leu Arg His Phe Gln Arg Ser 
                405                 410                 415     


Pro Ile Pro Leu Glu Cys Gly Ala Ala Cys Asp Val Arg Leu Ser Gly 
            420                 425                 430         


Tyr Val Val Val Leu Ser Gln Ala Pro Gly Ser Ser Asn Thr Val Leu 
        435                 440                 445             


Phe Pro Phe Ser Leu Pro His Trp Asp Ser Glu Leu Gly His Pro His 
    450                 455                 460                 


Leu Ser Ser Val Gly Cys Pro Pro Ser His Gly Ala Glu Ala Leu Pro 
465                 470                 475                 480 


Gly Gln Val Thr Pro Pro Glu Gln Ile Phe His Leu Val Pro Ser Pro 
                485                 490                 495     


Glu Glu Leu Ala Asn Ser Leu Arg Gln Leu Glu Leu Glu Ser Val Ser 
            500                 505                 510         


Ser Ala Arg Asp Ser Asp Tyr Asp Met Asp Ser Ser Ser Arg Gly His 
        515                 520                 525             


Leu Arg Ala Ile Asp Asn Gln Tyr Thr Pro Leu Ser Gln Leu Cys Arg 
    530                 535                 540                 


Glu Ala Asp Val 
545             


<210>  2
<211>  1647
<212>  DNA
<213>  Mus musculus

<400>  2
atgaacgagc ccaccgtgca gccgtcccgc acatcctccg cacccgcctc gccggcatcc       60

ccacgcggct ggagcgactt ctgcgagcag cacgcagcag cggcggcccg ggagctggcc      120

cgccagtact ggttgtttgc gcgcgcgcac ccacagccgc cgcgcgcgga cctggtgtcg      180

ctgcagttcg cggagctctt ccagcgccac ttctgccggg aggtgcgcga gagcctcgca      240

ggaccgccgg gtcacgacta ccgcgccact gctccgcccc gccccgcgct gcccaaggca      300

cgcagctccg aggacctggg cccgcggccc gcctgtgccc tgcagcacct gcgccgcggc      360

ctgcgccagc tcttccgccg ccgctcggca ggggagctgc ccggggctac cagtgacacc      420

aatgacatcg acaccaccgc agccagcagg ccgggcccgg cccgcaagtt gctaccctgg      480

ggcctgcgag agccgcccac tgaggcgctc aaggaggtcg tattgcgcta tagcctggcg      540

gacgaggcag caatggacag cggcgcacgc tggcagcggg gtcgcctggt gcttcggtct      600

ccaggtccgg gccacagcca ctttctgcag ctcttcgatc cgcccaagag ctcaaagccc      660

aagctccaag aggcctgttc cagcatccgg gaggtccgac catgtacacg cctggagatg      720

cctgacaacc tctacacctt tgtgttgaag gtgcaggacc agacagacat catctttgag      780

gtgggagatg aacagcagct gaactcatgg ctggcagagc tcagggcaag cacaggcctt      840

gggctggagc acccggacac cgagttacct ctttccttag cggcagagcc tggcccagct      900

agatccccaa ggggaagcac tgactccctg gaccaaggtg cttcacctgg ggtgttgctg      960

gacccagcct gccagaaaac agatcacttc ctatcctgct acccctggtt ccacggcccc     1020

atctccaggg tgagggctgc acagctggtc cagctccagg gccctgatgc ccacggcgtg     1080

ttcctggtgc ggcagagtga gtcccggaga ggagagtatg tactcacatt caacttacag     1140

ggcagagcca agcacttacg cctggtgctc acagagcgtg gacagtgccg ggtgcaacac     1200

ctgcacttcc cctcggtggt agatatgctc cgccacttcc agcgttctcc tatcccactg     1260

gaatgtggag cagcttgtga cgtccgactc tctggctatg tggtagtcct ctctcaggca     1320

ccaggttcct ccaacaccgt cctcttccct ttttcccttc ctcactggga ttcggagctg     1380

ggtcatcccc acctcagctc tgttggctgt ccccccagcc atggtgcaga ggctctccct     1440

ggccaagtga caccacctga gcagatcttc cacctggtgc cttctcctga ggaactggcc     1500

aacagtctgc ggcagctgga gctcgagtct gtgagcagtg cccgggactc ggactatgac     1560

atggactcct cttcacgggg ccaccttcgg gccattgaca accagtacac ccctctctca     1620

cagctgtgca gagaggcaga cgtgtga                                         1647


<210>  3
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asn Gly Pro Ala Leu Gln Pro Ser Ser Pro Ser Ser Ala Pro Ser 
1               5                   10                  15      


Ala Ser Pro Ala Ala Ala Pro Arg Gly Trp Ser Glu Phe Cys Glu Leu 
            20                  25                  30          


His Ala Val Ala Ala Ala Arg Glu Leu Ala Arg Gln Tyr Trp Leu Phe 
        35                  40                  45              


Ala Arg Glu His Pro Gln His Ala Pro Leu Arg Ala Glu Leu Val Ser 
    50                  55                  60                  


Leu Gln Phe Thr Asp Leu Phe Gln Arg Tyr Phe Cys Arg Glu Val Arg 
65                  70                  75                  80  


Asp Gly Arg Ala Pro Gly Arg Asp Tyr Arg Asp Thr Gly Arg Gly Pro 
                85                  90                  95      


Pro Ala Lys Ala Glu Ala Ser Pro Glu Pro Gly Pro Gly Pro Ala Ala 
            100                 105                 110         


Pro Gly Leu Pro Lys Ala Arg Ser Ser Glu Glu Leu Ala Pro Pro Arg 
        115                 120                 125             


Pro Pro Gly Pro Cys Ser Phe Gln His Phe Arg Arg Ser Leu Arg His 
    130                 135                 140                 


Ile Phe Arg Arg Arg Ser Ala Gly Glu Leu Pro Ala Ala His Thr Ala 
145                 150                 155                 160 


Ala Ala Pro Gly Thr Pro Gly Glu Ala Ala Glu Thr Pro Ala Arg Pro 
                165                 170                 175     


Gly Leu Ala Lys Lys Phe Leu Pro Trp Ser Leu Ala Arg Glu Pro Pro 
            180                 185                 190         


Pro Glu Ala Leu Lys Glu Ala Val Leu Arg Tyr Ser Leu Ala Asp Glu 
        195                 200                 205             


Ala Ser Met Asp Ser Gly Ala Arg Trp Gln Arg Gly Arg Leu Ala Leu 
    210                 215                 220                 


Arg Arg Ala Pro Gly Pro Asp Gly Pro Asp Arg Val Leu Glu Leu Phe 
225                 230                 235                 240 


Asp Pro Pro Lys Ser Ser Arg Pro Lys Leu Gln Ala Ala Cys Ser Ser 
                245                 250                 255     


Ile Gln Glu Val Arg Trp Cys Thr Arg Leu Glu Met Pro Asp Asn Leu 
            260                 265                 270         


Tyr Thr Phe Val Leu Lys Val Lys Asp Arg Thr Asp Ile Ile Phe Glu 
        275                 280                 285             


Val Gly Asp Glu Gln Gln Leu Asn Ser Trp Met Ala Glu Leu Ser Glu 
    290                 295                 300                 


Cys Thr Gly Arg Gly Leu Glu Ser Thr Glu Ala Glu Met His Ile Pro 
305                 310                 315                 320 


Ser Ala Leu Glu Pro Ser Thr Ser Ser Ser Pro Arg Gly Ser Thr Asp 
                325                 330                 335     


Ser Leu Asn Gln Gly Ala Ser Pro Gly Gly Leu Leu Asp Pro Ala Cys 
            340                 345                 350         


Gln Lys Thr Asp His Phe Leu Ser Cys Tyr Pro Trp Phe His Gly Pro 
        355                 360                 365             


Ile Ser Arg Val Lys Ala Ala Gln Leu Val Gln Leu Gln Gly Pro Asp 
    370                 375                 380                 


Ala His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg Arg Gly Glu 
385                 390                 395                 400 


Tyr Val Leu Thr Phe Asn Phe Gln Gly Ile Ala Lys His Leu Arg Leu 
                405                 410                 415     


Ser Leu Thr Glu Arg Gly Gln Cys Arg Val Gln His Leu His Phe Pro 
            420                 425                 430         


Ser Val Val Asp Met Leu His His Phe Gln Arg Ser Pro Ile Pro Leu 
        435                 440                 445             


Glu Cys Gly Ala Ala Cys Asp Val Arg Leu Ser Ser Tyr Val Val Val 
    450                 455                 460                 


Val Ser Gln Pro Pro Gly Ser Cys Asn Thr Val Leu Phe Pro Phe Ser 
465                 470                 475                 480 


Leu Pro His Trp Asp Ser Glu Ser Leu Pro His Trp Gly Ser Glu Leu 
                485                 490                 495     


Gly Leu Pro His Leu Ser Ser Ser Gly Cys Pro Arg Gly Leu Ser Pro 
            500                 505                 510         


Glu Gly Leu Pro Gly Arg Ser Ser Pro Pro Glu Gln Ile Phe His Leu 
        515                 520                 525             


Val Pro Ser Pro Glu Glu Leu Ala Asn Ser Leu Gln His Leu Glu His 
    530                 535                 540                 


Glu Pro Val Asn Arg Ala Arg Asp Ser Asp Tyr Glu Met Asp Ser Ser 
545                 550                 555                 560 


Ser Arg Ser His Leu Arg Ala Ile Asp Asn Gln Tyr Thr Pro Leu 
                565                 570                 575 


<210>  4
<211>  1728
<212>  DNA
<213>  Homo sapiens

<400>  4
atgaacgggc ctgccctgca gccctcctcg ccctcttccg cgccctcagc ctccccggcg       60

gcggccccgc ggggctggag cgagttctgt gagttgcacg ccgtagcggc ggcccgggag      120

ctggcccgcc agtactggct gttcgcccgg gagcatccgc agcacgcgcc gctgcgcgcc      180

gagctggtgt cgctgcagtt caccgacctc ttccagcgct acttctgccg cgaggtgcgc      240

gacggacggg cgccgggccg cgactaccgg gacacaggcc gtgggccccc agccaaggcc      300

gaggcgtccc cggagccagg ccccggcccc gccgcccctg gcctgcccaa ggcccgcagc      360

tctgaggagc tggccccgcc gcggccgccc gggccctgct ccttccagca ctttcgccgc      420

agcctccgcc acatcttccg ccgccgctcg gccggggagc tgccagcggc ccacaccgct      480

gccgcccccg ggacccccgg agaggctgct gagacccccg cccggcctgg cctggccaag      540

aagttcctgc cctggagcct ggcccgggag ccgccacccg aggcgctgaa ggaggcggtg      600

ctgcgctaca gcctggccga cgaggcctcc atggacagcg gggcacgctg gcagcgcggg      660

aggctggcgc tgcgccgggc cccgggcccc gatggccccg accgcgtgct ggagctcttc      720

gacccaccca agagttcaag gcccaagcta caagcagctt gctccagcat ccaggaggtc      780

cggtggtgca cacggcttga gatgcctgac aacctttaca cctttgtgct gaaggtgaag      840

gaccggacag acatcatctt tgaggtggga gacgagcagc agctgaattc atggatggct      900

gagctctcgg agtgcacagg ccgagggctg gagagcacag aagcagagat gcatattccc      960

tcagccctag agcctagcac gtccagctcc ccaaggggca gcacagattc ccttaaccaa     1020

ggtgcttctc ctggggggct gctggacccg gcctgccaga agacggacca tttcctgtcc     1080

tgctacccct ggttccacgg ccccatctcc agagtgaaag cagctcagct ggttcagctg     1140

cagggccctg atgctcatgg agtgttcctg gtgcggcaga gcgagacgcg gcgtggggaa     1200

tacgtgctca ctttcaactt tcaggggata gccaagcacc tgcgcctgtc gctgacagag     1260

cggggccagt gccgtgtgca gcacctccac tttccctcgg tcgtggacat gctccaccac     1320

ttccagcgct cgcccatccc actcgagtgc ggcgccgcct gtgatgtccg gctctccagc     1380

tacgtggtag tcgtctccca accaccaggt tcctgcaaca cggtcctctt ccctttctcc     1440

cttcctcact gggattcaga gtcccttcct cactggggtt cagagttggg ccttccccac     1500

cttagttctt ctggctgtcc ccgggggctc agcccagagg gtctcccagg gcgatcctca     1560

ccccccgagc agatcttcca cctggtgcct tcgcccgaag aactggccaa cagcctgcag     1620

cacctggagc atgagcctgt gaatcgagcc cgggactcgg actacgaaat ggactcatcc     1680

tcccggagcc acctgcgggc catagacaat cagtacacac ctctctga                  1728


