                         SEQUENCE LISTING

<110>  Novartis AG; Friedrich Miescher Institute for Biomedical
 
<120>  COMPOSITIONS AND METHODS TO TREAT BIETTI CRYSTALLINE DYSTROPHY

<130>  PAT058468-WO-PCT

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  130
<212>  DNA
<213>  Adeno-associated virus

<400>  1
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  2
<211>  2000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ProA18 promoter

<400>  2
attgaagacc tcagacttta gagataccag agctatggga tacctgctga gaaaagctgc       60

taacagggag tggaaccaga ccaggaaaaa gaagtttgtt acagtcaaca aagatgaatg      120

gaattggaga tctgatgagc actctgacat tagaaatgga gatgcagagt ttggagtttg      180

cctagctctt ttttggggtg tggggtgggg tgggtccttg tttgctccag tatttcctca      240

caatgacaat ttagaatgat ggtgtataca ctgcggtatt tgaggtatgt gatctgcttt      300

ttgattttga ctttatagga gattacagat aagtgatcaa atgaaactca gaaaagactt      360

tgacctttag acttttaaca ttattgagaa tgccatagac tatggagact tttgaagtgg      420

ggactaaatt tattttgcat catgctttgg ctaggtatgg cctccataga ctcatctgtt      480

cgaacaagcc taagggagcc aaggggtgga atgtggtggt ttgaatatgc ttggcccagg      540

aaggacacta ttaggaggta tggacttgct ggaagaagct tgtcactgtg ggagtgggct      600

ttgagatcct ttttctacct tgatgataat ggaccaaacg tctgaacctg taaaccagtc      660

ccaattaaat gttttctttt ataagagttg ccttggtcat ggtgtatact cacagcaatg      720

taaactctaa gatgggggac aatgggaggt gccagggcct acatgataga aggacaggca      780

ttgttacaat tccacctacc actcactaca tggtcttgga ctgatttgca accaacttct      840

ctccaatgtc ctcctcggaa atagagatgt cctggcatct cacccatggg gttatattta      900

ggaggctttt gatgatcatc cactagttca gtctaatatc tactacttta atagacatga      960

gttcctttgc taataaccct ctgggattta gtttctccat ctgaaaatta gttgtcctgt     1020

ggctcattgt tttctcgtga gaatttcagc atgagccagt acaaaagttg taccaagacc     1080

ttgtgtgtag aagccgaagt tcttagtggg tcatgaggta ctttcaaaaa gaatgcaagc     1140

cattctttat cctgagagat attttatgat tgcatagctc aatggctgtc tgtgagacag     1200

gaagtgaagc cctaaatcca tgatggagtt caaccagcac ttaactaggg aagggcatga     1260

agcagaaatg actcagttga caggaaaacc atccaatggc agcagtgcag agcagacagc     1320

cagtcatggc agactcagta ccagaggtca agggtcaggt actagtcaac atttgcttta     1380

tgacagcacg taactttaca aacctcaccc tgcccaccaa atgcttgcct acacatactt     1440

ctgagcctgt gaatgaacat acaacacaca cccacacaca tgcaaatgca cgcgcacaca     1500

cacacacaca ctcacacaca cacacacaca cacagagaga gagagagaga gagagagaga     1560

gagagagaga gagagagaga tgcacacaca caggcagctt gtcagcagct gtgcacatac     1620

aaggatctgg ctatccaatt ctcggggaca gctgcagctc aaatcctttc ttccacttcc     1680

ctcccttagt tatgcaaccc ttacccaatt cagctttcac tcacacacca tttggatcca     1740

agaccttaat cctgcctagt gggctggaat gaacaagaca gagctcattc cagcttcaca     1800

aaagctgcac tatccatcta ctgaatggat tctttctatg tgagccaaga ggaagactta     1860

gaaggataag aaataaaaaa ggtgttatta gtctaccata ataatctcca catgccagca     1920

agggagtgac catttaaaag gagagaccta gcttcagaga gccagaaaag agctgtgtag     1980

ctgacagagg gagtccaggg                                                 2000


<210>  3
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ProB4 promoter

<400>  3
gttctttggg ttccatattt tcctcattcc ccttcaagtc tagctggatt gcaaagttaa       60

gcttatgatt atgaataaaa actattgagt atattttcaa ggaaatagtg acttaccttt      120

taaggtcact tcctgctctt tcatctgacc cagaaacact gaataataaa gccatcattt      180

gttgaatgac cactgtgtaa tttttattta gaactctaat gttggtaatc tgcttggggc      240

tgtgggttaa gaatctttgg gttgcttgag gaaatgcact taattaaaat aaacattaaa      300

cttttccaca ctggcctttg tctccccctg gcggatccta gcaacagata ccagcaagtt      360

gtcttacttg gtatttaggg caatgtgatg cagccctaac ccaaagtgtt gtcacaccaa      420

acccttcaca cccaagagga tgtttcgctc tgaagtcatc agctctaaca aatatttgta      480

agtaaacagg tttttcttta aggaggcctt catttgtaac caacaccatg ctctcctttt      540

tcgctctctg aagtcatcag ctctaaagga aatcaatctc aatgccctat tataccctga      600

tctctggcct ttggaggggc tgttcaaaga ttctctgagg acttataggc taataaggtt      660

gaggattttg tgatttaaag aactccttaa tccactgctt cctgcctacc ataagccaag      720

gccacccttg cctttttttt tcttatcccc tgctgaacct gaaaaaccct ctcttttcta      780

cagttttctg ttcccaggcc ccaagtacag ttaaacaatt caactcaact tgtttaatcc      840

tctcgtctta aattattcac attgccaagt atttcaacag aatgtactgg caagttcata      900

aacagagtgc aaatcaccca agcagaagta atttactgct tttaagtcaa agccctgctt      960

agctagggag tcagctgtag gaattaacca gaacaaaatc ctgattaaac agctaatcgg     1020

ttctactccg ctaacccagt ggcctgagca aatcacaagg aggattggtt ccttgcatct     1080

ggtttgggca ccgcccacct ggaaccctag gggcggggcc gcttaagtgg caggagggat     1140

atatatcagg atgcaaaaga ccctgccaac tggaaaaata agaaggcagc agctttggat     1200

tttccactca tggaagaggg gaggaaaggg cagagggtgg gggcttcctt gggaagcttg     1260

ggatgagtca ccacgggatt ggggagtgga gggtggatag gatatggaga agggtgg        1317


<210>  9
<211>  272
<212>  DNA
<213>  Homo sapiens

<400>  9
ttcgaacagg taagcgcccc taaaatccct ttgggcacaa tgtgtcctga ggggagaggc       60

agcgacctgt agatgggacg ggggcactaa ccctcaggtt tggggcttct gaatgtgagt      120

atcgccatgt aagcccagta tttggccaat ctcagaaagc tcctggtccc tggagggatg      180

gagagagaaa aacaaacagc tcctggagca gggagagtgc tggcctcttg ctctccggct      240

ccctctgttg ccctctggtt tctccccagg tt                                    272


<210>  10
<211>  183
<212>  DNA
<213>  Simian virus 40

<400>  10
aactgaaaaa ccagaaagtt aactggtaag tttagtcttt ttgtctttta tttcaggtcc       60

cggatccggt ggtggtgcaa atcaaagaac tgctcctcag tggatgttgc ctttacttct      120

aggcctgtac ggaagtgtta cttctgctct aaaagctgcg gaattgtacc cgccccggga      180

tcc                                                                    183


<210>  11
<211>  493
<212>  DNA
<213>  Homo sapiens

<400>  11
cgaatcccgg ccgggaacgg tgcattggaa cgcggattcc ccgtgccaag agtgacgtaa       60

gtaccgccta tagagtctat aggcccacaa aaaatgcttt cttcttttaa tatacttttt      120

tgtttatctt atttctaata ctttccctaa tctctttctt tcagggcaat aatgatacaa      180

tgtatcatgc ctctttgcac cattctaaag aataacagtg ataatttctg ggttaaggca      240

atagcaatat ttctgcatat aaatatttct gcatataaat tgtaactgat gtaagaggtt      300

tcatattgct aatagcagct acaatccagc taccattctg cttttatttt atggttggga      360

taaggctgga ttattctgag tccaagctag gcccttttgc taatcatgtt catacctctt      420

atcttcctcc cacagctcct gggcaacgtg ctggtctgtg tgctggccca tcactttggc      480

aaagaattgg gat                                                         493


<210>  12
<211>  6
<212>  DNA
<213>  Unknown

<220>
<223>  Kozak sequence

<400>  12
gccacc                                                                   6


<210>  13
<211>  1578
<212>  DNA
<213>  Homo sapiens

<400>  13
atggcggggc tctggctggg gctcgtgtgg cagaagctgc tgctgtgggg cgcggcgagt       60

gccctttccc tggccggcgc cagtctggtc ctgagcctgc tgcagagggt ggcgagctac      120

gcgcggaaat ggcagcagat gcggcccatc cccacggtgg cccgcgccta cccactggtg      180

ggccacgcgc tgctgatgaa gccggacggg cgagaatttt ttcagcagat cattgagtac      240

acagaggaat accgccacat gccgctgctg aagctctggg tcgggccagt gcccatggtg      300

gccctttata atgcagaaaa tgtggaggta attttaacta gttcaaagca aattgacaaa      360

tcctctatgt acaagttttt agaaccatgg cttggcctag gacttcttac aagtactgga      420

aacaaatggc gctccaggag aaagatgtta acacccactt tccattttac cattctggaa      480

gatttcttag atatcatgaa tgaacaagca aatatattgg ttaagaaact tgaaaaacac      540

attaaccaag aagcatttaa ctgctttttt tacatcactc tttgtgcctt agatatcatc      600

tgtgaaacag ctatggggaa gaatattggt gctcaaagta atgatgattc cgagtatgtc      660

cgtgcagttt atagaatgag tgagatgata tttcgaagaa taaagatgcc ctggctttgg      720

cttgatctct ggtaccttat gtttaaagaa ggatgggaac acaaaaagag ccttcagatc      780

ctacatactt ttaccaacag tgtcatcgct gaacgggcca atgaaatgaa cgccaatgaa      840

gactgtagag gtgatggcag gggctctgcc ccctccaaaa ataaacgcag ggcctttctt      900

gacttgcttt taagtgtgac tgatgacgaa gggaacaggc taagtcatga agatattcga      960

gaagaagttg acaccttcat gtttgagggg cacgatacaa ctgcagctgc aataaactgg     1020

tccttatacc tgttgggttc taacccagaa gtccagaaaa aagtggatca tgaattggat     1080

gacgtgtttg ggaagtctga ccgtcccgct acagtagaag acctgaagaa acttcggtat     1140

ctggaatgtg ttattaagga gacccttcgc ctttttcctt ctgttccttt atttgcccgt     1200

agtgttagtg aagattgtga agtggcaggt tacagagttc taaaaggcac tgaagccgtc     1260

atcattccct atgcattgca cagagatccg agatacttcc ccaaccccga ggagttccag     1320

cctgagcggt tcttccccga gaatgcacaa gggcgccatc catatgccta cgtgcccttc     1380

tctgctggcc ccaggaactg tataggtcaa aagtttgctg tgatggaaga aaagaccatt     1440

ctttcgtgca tcctgaggca cttttggata gaatccaacc agaaaagaga agagcttggt     1500

ctagaaggac agttgattct tcgtccaagt aatggcatct ggatcaagtt gaagaggaga     1560

aatgcagatg aacgctaa                                                   1578


<210>  14
<211>  1578
<212>  DNA
<213>  Unknown

<220>
<223>  Codon-optimized CYP4V2 sequence

<400>  14
atggccggac tgtggctggg actggtctgg cagaagttat tactgtgggg agctgcctcc       60

gctctgtctt tagctggagc ttctttagtg ctgtctttac tgcagagggt cgcctcctat      120

gctaggaagt ggcagcagat gaggcctatt cctaccgtgg ccagagccta tcctttagtg      180

ggccacgctc tgctgatgaa acccgacgga agggagttct tccagcagat catcgagtac      240

accgaagagt acagacacat gcctttactg aaactgtggg tgggacccgt tcctatggtg      300

gctttataca atgccgagaa tgtggaggtg attttaacca gcagcaagca gatcgacaag      360

tccagcatgt ataagttttt agagccttgg ctcggtttag gactgctgac ctccactggt      420

aataagtgga ggtctcgtag gaaaatgctg acccccacct ttcacttcac cattttagag      480

gactttttag atatcatgaa cgagcaagct aacattttag tgaagaagct cgaaaagcac      540

attaaccaag aagctttcaa ctgttttttc tacatcactt tatgcgccct cgatatcatc      600

tgcgagacag ccatgggcaa gaacattggc gctcagagca acgacgattc cgagtacgtg      660

agggctgtct acagaatgag cgagatgatc ttcagaagaa tcaagatgcc ttggctgtgg      720

ctggacctct ggtatttaat gtttaaggaa ggctgggagc ataagaagtc tttacagatt      780

ttacatacat ttaccaacag cgtgatcgcc gagagggcca atgaaatgaa cgccaacgag      840

gattgtcgtg gcgacggaag aggctccgct ccttccaaga acaagaggag agccttttta      900

gatctcttat tatccgtgac agacgatgag ggcaataggc tgagccacga ggacatcaga      960

gaagaggtgg acaccttcat gttcgaggga cacgacacaa ccgccgccgc catcaattgg     1020

tctttatatt tactcggcag caaccccgag gtgcaaaaaa aggtcgacca cgagctcgac     1080

gacgtgttcg gcaagagcga tcgtcccgcc acagtggaag atttaaagaa gctgaggtat     1140

ctcgagtgcg tgatcaaaga gactttaaga ctgttcccca gcgtgcctct gtttgctcgt     1200

tccgtgtccg aagactgcga ggtggctgga tatcgtgtcc tcaagggcac cgaggccgtg     1260

atcattccct acgccctcca tcgtgatccc agatacttcc ccaatcccga ggagttccag     1320

cccgaaaggt tcttccccga aaacgctcaa ggcagacacc cttacgctta cgtgcctttc     1380

tccgccggcc ctcgtaactg cattggccag aaattcgccg tcatggagga aaagaccatt     1440

ttatcttgta ttttaaggca cttctggatc gaaagcaatc agaaaaggga ggaactcggt     1500

ttagaaggac agctgatttt aagacccagc aacggcattt ggatcaagct gaagaggagg     1560

aacgccgacg agaggtga                                                   1578


<210>  15
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Gly Leu Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Leu Ser Leu Ala Gly Ala Ser Leu Val Leu Ser 
            20                  25                  30          


Leu Leu Gln Arg Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Leu Met Lys Pro Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr 
65                  70                  75                  80  


Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro 
                85                  90                  95      


Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Leu Glu Lys His Ile Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys 
                245                 250                 255     


Ser Leu Gln Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly 
        275                 280                 285             


Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Lys Lys Val Asp His Glu Leu Asp Asp Val Phe Gly Lys Ser Asp Arg 
        355                 360                 365             


Pro Ala Thr Val Glu Asp Leu Lys Lys Leu Arg Tyr Leu Glu Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Val Ser Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asn Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ala Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Cys Ile Leu Arg His Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Glu Gly Gln Leu Ile Leu Arg Pro Ser Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Glu Arg 
        515                 520                 525 


<210>  16
<211>  730
<212>  DNA
<213>  Hepatitis B virus

<400>  16
taaacaggcc tattgattgg aaagtatgtc aacgaattgt gggtcttttg gggtttgctg       60

ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa      120

aacaggcttt tactttctcg ccaacttaca aggcctttct aagtaaacag tatctgaccc      180

tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca      240

ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc      300

cgatccatac tgcggaactc ctagccgctt gttttgctcg cagcaggtct ggagcgaaac      360

tcatcgggac tgacaattct gtcgtgctct cccgcaagta tacatcgttt ccagggctgc      420

taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc      480

tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc      540

tgccgtaccg accgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt      600

ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg agaccaccgt      660

gaacgcccac cggaacctgc ccaaggtctt gcataagagg actcttggac tttcagcaat      720

gtcaactcga                                                             730


<210>  17
<211>  588
<212>  DNA
<213>  Woodchuck hepatitis virus

<400>  17
tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc       60

ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat      120

ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg      180

gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg      240

ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat      300

tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt      360

gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc      420

ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa      480

tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg      540

ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgca                   588


<210>  18
<211>  245
<212>  DNA
<213>  Bovine

<400>  18
gatctggatg atgacgacaa gtgaggatcc ctgtgccttc tagttgccag ccatctgttg       60

tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct      120

aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg      180

gggtggggca ggacagcaag ggggaggatt gggaagagaa tagcaggcat gctggggaga      240

attca                                                                  245


<210>  19
<211>  236
<212>  DNA
<213>  Simian virus 40

<400>  19
gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca       60

cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc      120

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt      180

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtct          236


<210>  20
<211>  2454
<212>  DNA
<213>  Unknown

<220>
<223>  SYNUCLEIN INTRONIC SEQUENCE AS STUFFER SEQUENCE

<400>  20
gggccccggt gttatctcat tcttttttct cctctgtaag ttgacatgtg atgtgggaac       60

aaaggggata aagtcattat tttgtgctaa aatcgtaatt ggagaggacc tcctgttagc      120

tgggctttct tctatttatt gtggtggtta ctggagttcc ttcttctagt tttaggatat      180

atatatatat tttttttttt tctttccctg aagatataat aatatatata cttctgaaga      240

ttgagatttt taaattagtt gtattgaaaa ctagctaatc agcaatttaa ggctagcttg      300

agacttatgt cttgaatttg tttttgtagg ctccaaaacc aaggagggag tggtgcatgg      360

tgtggcaaca ggtaagctcc attgtgctta tatccaaaga tgatatttaa agtatctagt      420

gattagtgtg gcccagtatt caagattcct atgaaattgt aaaacaatca ctgagcattc      480

taagaacata tcagtcttat tgaaactgaa ttctttataa agtattttta aaaaggtaaa      540

tattgattat aaataaaaaa tatacttgcc aagaataatg agggctttga attgataagc      600

tatgtttaat ttatagtaag tgggcattta aatattctga ccaaaaatgt attgacaaac      660

tgctgacaaa aataaaatgt gaatattgcc ataattttaa aaaaagagta aaatttctgt      720

tgattacagt aaaatatttt gaccttaaat tatgttgatt acaatattcc tttgataatt      780

cagagtgcat ttcaggaaac acccttggac agtcagtaaa ttgtttattg tatttatctt      840

tgtattgtta tggtatagct atttgtacaa atattattgt gcaattatta catttctgat      900

tatattattc atttggccta aatttaccaa gaatttgaac aagtcaatta ggtttacaat      960

caagaaatat caaaaatgat gaaaaggatg ataatcatca tcagatgttg aggaagatga     1020

cgatgagagt gccagaaata gagaaatcaa aggagaacca aaatttaaca aattaaaagc     1080

ccacagactt gctgtaatta agttttctgt tgtaagtact ccacgtttcc tggcagatgt     1140

ggtgaagcaa aagatataat cagaaatata atttatatga tcggaaagca ttaaacacaa     1200

tagtgcctat acaaataaaa tgttcctatc actgacttct aaaatggaaa tgaggacaat     1260

gatatgggaa tcttaataca gtgttgtgga taggactaaa aacacaggag tcagatcttc     1320

ttggttcaac ttcctgctta ctccttacca gctgtgtgtt ttttgcaagg ttcttcacct     1380

ctatgtgatt tagcttcctc atctataaaa taattcagtg aattaatgta cacaaaacat     1440

ctggaaaaca aaagcaaaca atatgtattt tataagtgtt acttatagtt ttatagtgaa     1500

ctttcttgtg caacattttt acaactagtg gagaaaaata tttctttaaa tgaatacttt     1560

tgatttaaaa atcagagtgt aaaaataaaa cagactcctt tgaaactagt tctgttagaa     1620

gttaattgtg cacctttaat gggctctgtt gcaatccaac agagaagtag ttaagtaagt     1680

ggactatgat ggcttctagg gacctcctat aaatatgata ttgtgaagca tgattataat     1740

aagaactaga taacagacag gtggagactc cactatctga agagggtcaa cctagatgaa     1800

tggtgttcca tttagtagtt gaggaagaac ccatgaggtt tagaaagcag acaagcatgt     1860

ggcaagttct ggagtcagtg gtaaaaatta aagaacccaa ctattactgt cacctaatga     1920

tctaatggag actgtggaga tgggctgcat ttttttaatc ttctccagaa tgccaaaatg     1980

taaacacata tctgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgagagag agagagagag     2040

agagagagac tgaagtttgt acaattagac attttataaa atgttttctg aaggacagtg     2100

gctcacaatc ttaagtttct aacattgtac aatgttggga gactttgtat actttatttt     2160

ctctttagca tattaaggaa tctgagatgt cctacagtaa agaaatttgc attacatagt     2220

taaaatcagg gttattcaaa ctttttgatt attgaaacct ttcttcatta gttactaggg     2280

ttgaatgaaa ctagtgttcc acagaaaact atgggaaatg ttgctaggca gtaaggacat     2340

ggtgatttca gcatgtgcaa tatttacagc gattgcaccc atggaccacc ctggcagtag     2400

tgaaataacc aaaaatgctg tcataactag tatggctatg agaaacacat tggg           2454


<210>  21
<211>  1503
<212>  DNA
<213>  Unknown

<220>
<223>  RLBP1 INTRONIC SEQUENCE AS STUFFER SEQUENCE

<400>  21
attctccagg ttgagccaga ccaatttgat ggtagattta gcaaataaaa atacaggaca       60

cccagttaaa tgtgaatttc cgatgaacag caaatacttt tttagtatta aaaaagttca      120

catttaggct cacgcctgta atcccagcac tttgggaggc cgaggcaggc agatcacctg      180

aggtcaggag ttcgagacca gcctggccaa catggtgaaa ccccatctcc actaaaaata      240

ccaaaaatta gccaggcgtg ctggtgggca cctgtagttc cagctactca ggaggctaag      300

gcaggagaat tgcttgaacc tgggaggcag aggttgcagt gagctgagat cgcaccattg      360

cactctagcc tgggcgacaa gaacaaaact ccatctcaaa aaaaaaaaaa aaaaaaaagt      420

tcacatttaa ctgggcattc tgtatttaat tggtaatctg agatggcagg gaacagcatc      480

agcatggtgt gagggatagg cattttttca ttgtgtacag cttgtaaatc agtattttta      540

aaactcaaag ttaatggctt gggcatattt agaaaagagt tgccgcacgg acttgaaccc      600

tgtattccta aaatctagga tcttgttctg atggtctgca caactggctg ggggtgtcca      660

gccactgtcc ctcttgcctg ggctccccag ggcagttctg tcagcctctc catttccatt      720

cctgttccag caaaacccaa ctgatagcac agcagcattt cagcctgtct acctctgtgc      780

ccacatacct ggatgtctac cagccagaaa ggtggcttag atttggttcc tgtgggtgga      840

ttatggcccc cagaacttcc ctgtgcttgc tgggggtgtg gagtggaaag agcaggaaat      900

gggggaccct ccgatactct atgggggtcc tccaagtctc tttgtgcaag ttagggtaat      960

aatcaatatg gagctaagaa agagaagggg aactatgctt tagaacagga cactgtgcca     1020

ggagcattgc agaaattata tggttttcac gacagttctt tttggtaggt actgttatta     1080

tcctcagttt gcagatgagg aaactgagac ccagaaaggt taaataactt gctagggtca     1140

cacaagtcat aactgacaaa gcctgattca aacccaggtc tccctaacct ttaaggtttc     1200

tatgacgcca gctctcctag ggagtttgtc ttcagatgtc ttggctctag gtgtcaaaaa     1260

aagacttggt gtcaggcagg cataggttca agtcccaact ctgtcactta ccaactgtga     1320

ctaggtgatt gaactgacca tggaacctgg tcacatgcag gagcaggatg gtgaagggtt     1380

cttgaaggca cttaggcagg acatttaggc aggagagaaa acctggaaac agaagagctg     1440

tctccaaaaa tacccactgg ggaagcaggt tgtcatgtgg gccatgaatg ggacctgttc     1500

tgg                                                                   1503


<210>  22
<211>  130
<212>  DNA
<213>  Adeno-associated virus

<400>  22
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  23
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  23
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210>  24
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  24

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  25
<211>  601
<212>  PRT
<213>  Adeno-associated virus

<400>  25

Met Ala Pro Gly Lys Lys Arg Pro Val Glu Pro Ser Pro Gln Arg Ser 
1               5                   10                  15      


Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln Gln Pro Ala Arg 
            20                  25                  30          


Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser Val Pro Asp 
        35                  40                  45              


Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser Gly Val Gly Pro 
    50                  55                  60                  


Asn Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu 
65                  70                  75                  80  


Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser 
                85                  90                  95      


Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala 
            100                 105                 110         


Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Gly Thr 
        115                 120                 125             


Ser Gly Gly Ala Thr Asn Asp Asn Thr Tyr Phe Gly Tyr Ser Thr Pro 
    130                 135                 140                 


Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg 
145                 150                 155                 160 


Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg 
                165                 170                 175     


Leu Ser Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn 
            180                 185                 190         


Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln Val 
        195                 200                 205             


Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His 
    210                 215                 220                 


Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln 
225                 230                 235                 240 


Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser 
                245                 250                 255     


Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
            260                 265                 270         


Asn Asn Phe Gln Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser 
        275                 280                 285             


Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
    290                 295                 300                 


Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Thr Gly Gly Thr 
305                 310                 315                 320 


Ala Asn Thr Gln Thr Leu Gly Phe Ser Gln Gly Gly Pro Asn Thr Met 
                325                 330                 335     


Ala Asn Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
            340                 345                 350         


Arg Val Ser Thr Thr Thr Gly Gln Asn Asn Asn Ser Asn Phe Ala Trp 
        355                 360                 365             


Thr Ala Gly Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Ala Asn 
    370                 375                 380                 


Pro Gly Ile Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe 
385                 390                 395                 400 


Pro Ser Asn Gly Ile Leu Ile Phe Gly Lys Gln Asn Ala Ala Arg Asp 
                405                 410                 415     


Asn Ala Asp Tyr Ser Asp Val Met Leu Thr Ser Glu Glu Glu Ile Lys 
            420                 425                 430         


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asp Asn 
        435                 440                 445             


Leu Gln Gln Gln Asn Thr Ala Pro Gln Ile Gly Thr Val Asn Ser Gln 
    450                 455                 460                 


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
465                 470                 475                 480 


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
                485                 490                 495     


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
            500                 505                 510         


Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr Phe Asn 
        515                 520                 525             


Gln Ser Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
    530                 535                 540                 


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
545                 550                 555                 560 


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr Ser Val 
                565                 570                 575     


Asp Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile 
            580                 585                 590         


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
        595                 600     


<210>  26
<211>  535
<212>  PRT
<213>  Adeno-associated virus

<400>  26

Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly 
    50                  55                  60                  


Gly Ala Thr Asn Asp Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
65                  70                  75                  80  


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
                85                  90                  95      


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser 
            100                 105                 110         


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly 
        115                 120                 125             


Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr 
    130                 135                 140                 


Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly 
145                 150                 155                 160 


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
                165                 170                 175     


Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
            180                 185                 190         


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
        195                 200                 205             


Phe Gln Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr 
    210                 215                 220                 


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
225                 230                 235                 240 


Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn 
                245                 250                 255     


Thr Gln Thr Leu Gly Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn 
            260                 265                 270         


Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val 
        275                 280                 285             


Ser Thr Thr Thr Gly Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala 
    290                 295                 300                 


Gly Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly 
305                 310                 315                 320 


Ile Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser 
                325                 330                 335     


Asn Gly Ile Leu Ile Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala 
            340                 345                 350         


Asp Tyr Ser Asp Val Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr 
        355                 360                 365             


Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln 
    370                 375                 380                 


Gln Gln Asn Thr Ala Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala 
385                 390                 395                 400 


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro 
                405                 410                 415     


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
            420                 425                 430         


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
        435                 440                 445             


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser 
    450                 455                 460                 


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
465                 470                 475                 480 


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
                485                 490                 495     


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe 
            500                 505                 510         


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
        515                 520                 525             


Arg Tyr Leu Thr Arg Asn Leu 
    530                 535 


<210>  27
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  27
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210>  28
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  28

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  29
<211>  599
<212>  PRT
<213>  Adeno-associated virus

<400>  29

Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln Ser Pro Gln Glu Pro 
1               5                   10                  15      


Asp Ser Ser Ala Gly Ile Gly Lys Ser Gly Ala Gln Pro Ala Lys Lys 
            20                  25                  30          


Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu Ser Val Pro Asp Pro 
        35                  40                  45              


Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser Gly Val Gly Ser Leu 
    50                  55                  60                  


Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala Asp Asn Asn Glu Gly 
65                  70                  75                  80  


Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln 
                85                  90                  95      


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
            100                 105                 110         


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
        115                 120                 125             


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
    130                 135                 140                 


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
145                 150                 155                 160 


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
                165                 170                 175     


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
            180                 185                 190         


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
        195                 200                 205             


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
    210                 215                 220                 


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
225                 230                 235                 240 


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
                245                 250                 255     


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
            260                 265                 270         


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
        275                 280                 285             


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
    290                 295                 300                 


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn 
305                 310                 315                 320 


Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
                325                 330                 335     


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
            340                 345                 350         


Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
        355                 360                 365             


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
    370                 375                 380                 


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
385                 390                 395                 400 


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
                405                 410                 415     


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
            420                 425                 430         


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
        435                 440                 445             


Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
    450                 455                 460                 


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
465                 470                 475                 480 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
                485                 490                 495     


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
            500                 505                 510         


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
        515                 520                 525             


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
    530                 535                 540                 


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
545                 550                 555                 560 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
                565                 570                 575     


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
            580                 585                 590         


Arg Tyr Leu Thr Arg Asn Leu 
        595                 


<210>  30
<211>  534
<212>  PRT
<213>  Adeno-associated virus

<400>  30

Met Ala Ser Gly Gly Gly Ala Pro Val Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp 
            20                  25                  30          


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly 
    50                  55                  60                  


Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
65                  70                  75                  80  


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
                85                  90                  95      


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
            100                 105                 110         


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
        115                 120                 125             


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
    130                 135                 140                 


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
145                 150                 155                 160 


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
                165                 170                 175     


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
            180                 185                 190         


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
        195                 200                 205             


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
    210                 215                 220                 


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
225                 230                 235                 240 


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
                245                 250                 255     


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
            260                 265                 270         


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
        275                 280                 285             


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
    290                 295                 300                 


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
305                 310                 315                 320 


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
                325                 330                 335     


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
            340                 345                 350         


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
        355                 360                 365             


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
    370                 375                 380                 


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
385                 390                 395                 400 


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
                405                 410                 415     


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
            420                 425                 430         


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
        435                 440                 445             


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
    450                 455                 460                 


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
465                 470                 475                 480 


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
                485                 490                 495     


Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala 
            500                 505                 510         


Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
        515                 520                 525             


Tyr Leu Thr Arg Asn Leu 
    530                 


<210>  31
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  31
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  32
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  32

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  33
<211>  598
<212>  PRT
<213>  Adeno-associated virus

<400>  33

Met Ala Pro Gly Lys Lys Arg Pro Val Glu His Ser Pro Val Glu Pro 
1               5                   10                  15      


Asp Ser Ser Ser Gly Thr Gly Lys Ala Gly Gln Gln Pro Ala Arg Lys 
            20                  25                  30          


Arg Leu Asn Phe Gly Gln Thr Gly Asp Ala Asp Ser Val Pro Asp Pro 
        35                  40                  45              


Gln Pro Leu Gly Gln Pro Pro Ala Ala Pro Ser Gly Leu Gly Thr Asn 
    50                  55                  60                  


Thr Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly 
65                  70                  75                  80  


Ala Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr 
                85                  90                  95      


Trp Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
            100                 105                 110         


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly 
        115                 120                 125             


Ala Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
    130                 135                 140                 


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
145                 150                 155                 160 


Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe 
                165                 170                 175     


Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr 
            180                 185                 190         


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
        195                 200                 205             


Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys 
    210                 215                 220                 


Leu Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
225                 230                 235                 240 


Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr 
                245                 250                 255     


Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe 
            260                 265                 270         


Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala 
        275                 280                 285             


His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr 
    290                 295                 300                 


Leu Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln 
305                 310                 315                 320 


Ser Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln 
                325                 330                 335     


Ser Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser 
            340                 345                 350         


Lys Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala 
        355                 360                 365             


Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro 
    370                 375                 380                 


Ala Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser 
385                 390                 395                 400 


Gly Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp 
                405                 410                 415     


Ile Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn 
            420                 425                 430         


Pro Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg 
        435                 440                 445             


Gly Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu 
    450                 455                 460                 


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
465                 470                 475                 480 


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
                485                 490                 495     


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
            500                 505                 510         


Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys 
        515                 520                 525             


Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
    530                 535                 540                 


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 


Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr 
                565                 570                 575     


Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
            580                 585                 590         


Tyr Leu Thr Arg Asn Leu 
        595             


<210>  34
<211>  533
<212>  PRT
<213>  Adeno-associated virus

<400>  34

Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala 
    50                  55                  60                  


Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe 
65                  70                  75                  80  


Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
                85                  90                  95      


Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys 
            100                 105                 110         


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr 
        115                 120                 125             


Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser 
    130                 135                 140                 


Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu 
145                 150                 155                 160 


Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu 
                165                 170                 175     


Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys 
            180                 185                 190         


Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr 
        195                 200                 205             


Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His 
    210                 215                 220                 


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu 
225                 230                 235                 240 


Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser 
                245                 250                 255     


Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser 
            260                 265                 270         


Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys 
        275                 280                 285             


Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr 
    290                 295                 300                 


Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala 
305                 310                 315                 320 


Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile 
            340                 345                 350         


Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro 
        355                 360                 365             


Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly 
    370                 375                 380                 


Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro 
385                 390                 395                 400 


Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
                405                 410                 415     


Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met 
            420                 425                 430         


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn 
        435                 440                 445             


Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe 
    450                 455                 460                 


Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile 
465                 470                 475                 480 


Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
                485                 490                 495     


Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val 
            500                 505                 510         


Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr 
        515                 520                 525             


Leu Thr Arg Asn Leu 
    530             


<210>  35
<211>  2175
<212>  PRT
<213>  Adeno-associated virus

<400>  35

Ala Thr Gly Thr Cys Thr Thr Thr Thr Gly Thr Thr Gly Ala Thr Cys 
1               5                   10                  15      


Ala Cys Cys Cys Thr Cys Cys Ala Gly Ala Thr Thr Gly Gly Thr Thr 
            20                  25                  30          


Gly Gly Ala Ala Gly Ala Ala Gly Thr Thr Gly Gly Thr Gly Ala Ala 
        35                  40                  45              


Gly Gly Thr Cys Thr Thr Cys Gly Cys Gly Ala Gly Thr Thr Thr Thr 
    50                  55                  60                  


Thr Gly Gly Gly Cys Cys Thr Thr Gly Ala Ala Gly Cys Gly Gly Gly 
65                  70                  75                  80  


Cys Cys Cys Ala Cys Cys Gly Ala Ala Ala Cys Cys Ala Ala Ala Ala 
                85                  90                  95      


Cys Cys Cys Ala Ala Thr Cys Ala Gly Cys Ala Gly Cys Ala Thr Cys 
            100                 105                 110         


Ala Ala Gly Ala Thr Cys Ala Ala Gly Cys Cys Cys Gly Thr Gly Gly 
        115                 120                 125             


Thr Cys Thr Thr Gly Thr Gly Cys Thr Gly Cys Cys Thr Gly Gly Thr 
    130                 135                 140                 


Thr Ala Thr Ala Ala Cys Thr Ala Thr Cys Thr Cys Gly Gly Ala Cys 
145                 150                 155                 160 


Cys Cys Gly Gly Ala Ala Ala Cys Gly Gly Thr Cys Thr Cys Gly Ala 
                165                 170                 175     


Thr Cys Gly Ala Gly Gly Ala Gly Ala Gly Cys Cys Thr Gly Thr Cys 
            180                 185                 190         


Ala Ala Cys Ala Gly Gly Gly Cys Ala Gly Ala Cys Gly Ala Gly Gly 
        195                 200                 205             


Thr Cys Gly Cys Gly Cys Gly Ala Gly Ala Gly Cys Ala Cys Gly Ala 
    210                 215                 220                 


Cys Ala Thr Cys Thr Cys Gly Thr Ala Cys Ala Ala Cys Gly Ala Gly 
225                 230                 235                 240 


Cys Ala Gly Cys Thr Thr Gly Ala Gly Gly Cys Gly Gly Gly Ala Gly 
                245                 250                 255     


Ala Cys Ala Ala Cys Cys Cys Cys Thr Ala Cys Cys Thr Cys Ala Ala 
            260                 265                 270         


Gly Thr Ala Cys Ala Ala Cys Cys Ala Cys Gly Cys Gly Gly Ala Cys 
        275                 280                 285             


Gly Cys Cys Gly Ala Gly Thr Thr Thr Cys Ala Gly Gly Ala Gly Ala 
    290                 295                 300                 


Ala Gly Cys Thr Cys Gly Cys Cys Gly Ala Cys Gly Ala Cys Ala Cys 
305                 310                 315                 320 


Ala Thr Cys Cys Thr Thr Cys Gly Gly Gly Gly Gly Ala Ala Ala Cys 
                325                 330                 335     


Cys Thr Cys Gly Gly Ala Ala Ala Gly Gly Cys Ala Gly Thr Cys Thr 
            340                 345                 350         


Thr Thr Cys Ala Gly Gly Cys Cys Ala Ala Gly Ala Ala Ala Ala Gly 
        355                 360                 365             


Gly Gly Thr Thr Cys Thr Cys Gly Ala Ala Cys Cys Thr Thr Thr Thr 
    370                 375                 380                 


Gly Gly Cys Cys Thr Gly Gly Thr Thr Gly Ala Ala Gly Ala Gly Gly 
385                 390                 395                 400 


Gly Thr Gly Cys Thr Ala Ala Gly Ala Cys Gly Gly Cys Cys Cys Cys 
                405                 410                 415     


Thr Ala Cys Cys Gly Gly Ala Ala Ala Gly Cys Gly Gly Ala Thr Ala 
            420                 425                 430         


Gly Ala Cys Gly Ala Cys Cys Ala Cys Thr Thr Thr Cys Cys Ala Ala 
        435                 440                 445             


Ala Ala Ala Gly Ala Ala Ala Gly Ala Ala Gly Gly Cys Thr Cys Gly 
    450                 455                 460                 


Gly Ala Cys Cys Gly Ala Ala Gly Ala Gly Gly Ala Cys Thr Cys Cys 
465                 470                 475                 480 


Ala Ala Gly Cys Cys Thr Thr Cys Cys Ala Cys Cys Thr Cys Gly Thr 
                485                 490                 495     


Cys Ala Gly Ala Cys Gly Cys Cys Gly Ala Ala Gly Cys Thr Gly Gly 
            500                 505                 510         


Ala Cys Cys Cys Ala Gly Cys Gly Gly Ala Thr Cys Cys Cys Ala Gly 
        515                 520                 525             


Cys Ala Gly Cys Thr Gly Cys Ala Ala Ala Thr Cys Cys Cys Ala Gly 
    530                 535                 540                 


Cys Cys Cys Ala Ala Cys Cys Ala Gly Cys Cys Thr Cys Ala Ala Gly 
545                 550                 555                 560 


Thr Thr Thr Gly Gly Gly Ala Gly Cys Thr Gly Ala Thr Ala Cys Ala 
                565                 570                 575     


Ala Thr Gly Thr Cys Thr Gly Cys Gly Gly Gly Ala Gly Gly Thr Gly 
            580                 585                 590         


Gly Cys Gly Gly Cys Cys Cys Ala Thr Thr Gly Gly Gly Cys Gly Ala 
        595                 600                 605             


Cys Ala Ala Thr Ala Ala Cys Cys Ala Ala Gly Gly Thr Gly Cys Cys 
    610                 615                 620                 


Gly Ala Thr Gly Gly Ala Gly Thr Gly Gly Gly Cys Ala Ala Thr Gly 
625                 630                 635                 640 


Cys Cys Thr Cys Gly Gly Gly Ala Gly Ala Thr Thr Gly Gly Cys Ala 
                645                 650                 655     


Thr Thr Gly Cys Gly Ala Thr Thr Cys Cys Ala Cys Gly Thr Gly Gly 
            660                 665                 670         


Ala Thr Gly Gly Gly Gly Gly Ala Cys Ala Gly Ala Gly Thr Cys Gly 
        675                 680                 685             


Thr Cys Ala Cys Cys Ala Ala Gly Thr Cys Cys Ala Cys Cys Cys Gly 
    690                 695                 700                 


Ala Ala Cys Cys Thr Gly Gly Gly Thr Gly Cys Thr Gly Cys Cys Cys 
705                 710                 715                 720 


Ala Gly Cys Thr Ala Cys Ala Ala Cys Ala Ala Cys Cys Ala Cys Cys 
                725                 730                 735     


Ala Gly Thr Ala Cys Cys Gly Ala Gly Ala Gly Ala Thr Cys Ala Ala 
            740                 745                 750         


Ala Ala Gly Cys Gly Gly Cys Thr Cys Cys Gly Thr Cys Gly Ala Cys 
        755                 760                 765             


Gly Gly Ala Ala Gly Cys Ala Ala Cys Gly Cys Cys Ala Ala Cys Gly 
    770                 775                 780                 


Cys Cys Thr Ala Cys Thr Thr Thr Gly Gly Ala Thr Ala Cys Ala Gly 
785                 790                 795                 800 


Cys Ala Cys Cys Cys Cys Cys Thr Gly Gly Gly Gly Gly Thr Ala Cys 
                805                 810                 815     


Thr Thr Thr Gly Ala Cys Thr Thr Thr Ala Ala Cys Cys Gly Cys Thr 
            820                 825                 830         


Thr Cys Cys Ala Cys Ala Gly Cys Cys Ala Cys Thr Gly Gly Ala Gly 
        835                 840                 845             


Cys Cys Cys Cys Cys Gly Ala Gly Ala Cys Thr Gly Gly Cys Ala Ala 
    850                 855                 860                 


Ala Gly Ala Cys Thr Cys Ala Thr Cys Ala Ala Cys Ala Ala Cys Thr 
865                 870                 875                 880 


Ala Cys Thr Gly Gly Gly Gly Cys Thr Thr Cys Ala Gly Ala Cys Cys 
                885                 890                 895     


Cys Cys Gly Gly Thr Cys Cys Cys Thr Cys Ala Gly Ala Gly Thr Cys 
            900                 905                 910         


Ala Ala Ala Ala Thr Cys Thr Thr Cys Ala Ala Cys Ala Thr Thr Cys 
        915                 920                 925             


Ala Ala Gly Thr Cys Ala Ala Ala Gly Ala Gly Gly Thr Cys Ala Cys 
    930                 935                 940                 


Gly Gly Thr Gly Cys Ala Gly Gly Ala Cys Thr Cys Cys Ala Cys Cys 
945                 950                 955                 960 


Ala Cys Cys Ala Cys Cys Ala Thr Cys Gly Cys Cys Ala Ala Cys Ala 
                965                 970                 975     


Ala Cys Cys Thr Cys Ala Cys Cys Thr Cys Cys Ala Cys Cys Gly Thr 
            980                 985                 990         


Cys Cys Ala Ala Gly Thr Gly Thr  Thr Thr Ala Cys Gly  Gly Ala Cys 
        995                 1000                 1005             


Gly Ala  Cys Gly Ala Cys Thr  Ala Cys Cys Ala Gly  Cys Thr Gly 
    1010                 1015                 1020             


Cys Cys  Cys Thr Ala Cys Gly  Thr Cys Gly Thr Cys  Gly Gly Cys 
    1025                 1030                 1035             


Ala Ala  Cys Gly Gly Gly Ala  Cys Cys Gly Ala Gly  Gly Gly Ala 
    1040                 1045                 1050             


Thr Gly  Cys Cys Thr Gly Cys  Cys Gly Gly Cys Cys  Thr Thr Cys 
    1055                 1060                 1065             


Cys Cys  Thr Cys Cys Gly Cys  Ala Gly Gly Thr Cys  Thr Thr Thr 
    1070                 1075                 1080             


Ala Cys  Gly Cys Thr Gly Cys  Cys Gly Cys Ala Gly  Thr Ala Cys 
    1085                 1090                 1095             


Gly Gly  Thr Thr Ala Cys Gly  Cys Gly Ala Cys Gly  Cys Thr Gly 
    1100                 1105                 1110             


Ala Ala  Cys Cys Gly Cys Gly  Ala Cys Ala Ala Cys  Ala Cys Ala 
    1115                 1120                 1125             


Gly Ala  Ala Ala Ala Thr Cys  Cys Cys Ala Cys Cys  Gly Ala Gly 
    1130                 1135                 1140             


Ala Gly  Gly Ala Gly Cys Ala  Gly Cys Thr Thr Cys  Thr Thr Cys 
    1145                 1150                 1155             


Thr Gly  Cys Cys Thr Ala Gly  Ala Gly Thr Ala Cys  Thr Thr Thr 
    1160                 1165                 1170             


Cys Cys  Cys Ala Gly Cys Ala  Ala Gly Ala Thr Gly  Cys Thr Gly 
    1175                 1180                 1185             


Ala Gly  Ala Ala Cys Gly Gly  Gly Cys Ala Ala Cys  Ala Ala Cys 
    1190                 1195                 1200             


Thr Thr  Thr Gly Ala Gly Thr  Thr Thr Ala Cys Cys  Thr Ala Cys 
    1205                 1210                 1215             


Ala Ala  Cys Thr Thr Thr Gly  Ala Gly Gly Ala Gly  Gly Thr Gly 
    1220                 1225                 1230             


Cys Cys  Cys Thr Thr Cys Cys  Ala Cys Thr Cys Cys  Ala Gly Cys 
    1235                 1240                 1245             


Thr Thr  Cys Gly Cys Thr Cys  Cys Cys Ala Gly Thr  Cys Ala Gly 
    1250                 1255                 1260             


Ala Ala  Cys Cys Thr Cys Thr  Thr Cys Ala Ala Gly  Cys Thr Gly 
    1265                 1270                 1275             


Gly Cys  Cys Ala Ala Cys Cys  Cys Gly Cys Thr Gly  Gly Thr Gly 
    1280                 1285                 1290             


Gly Ala  Cys Cys Ala Gly Thr  Ala Cys Thr Thr Gly  Thr Ala Cys 
    1295                 1300                 1305             


Cys Gly  Cys Thr Thr Cys Gly  Thr Gly Ala Gly Cys  Ala Cys Ala 
    1310                 1315                 1320             


Ala Ala  Thr Ala Ala Cys Ala  Cys Thr Gly Gly Cys  Gly Gly Ala 
    1325                 1330                 1335             


Gly Thr  Cys Cys Ala Gly Thr  Thr Cys Ala Ala Cys  Ala Ala Gly 
    1340                 1345                 1350             


Ala Ala  Cys Cys Thr Gly Gly  Cys Cys Gly Gly Gly  Ala Gly Ala 
    1355                 1360                 1365             


Thr Ala  Cys Gly Cys Cys Ala  Ala Cys Ala Cys Cys  Thr Ala Cys 
    1370                 1375                 1380             


Ala Ala  Ala Ala Ala Cys Thr  Gly Gly Thr Thr Cys  Cys Cys Gly 
    1385                 1390                 1395             


Gly Gly  Gly Cys Cys Cys Ala  Thr Gly Gly Gly Cys  Cys Gly Ala 
    1400                 1405                 1410             


Ala Cys  Cys Cys Ala Gly Gly  Gly Cys Thr Gly Gly  Ala Ala Cys 
    1415                 1420                 1425             


Cys Thr  Gly Gly Gly Cys Thr  Cys Cys Gly Gly Gly  Gly Thr Cys 
    1430                 1435                 1440             


Ala Ala  Cys Cys Gly Cys Gly  Cys Cys Ala Gly Thr  Gly Thr Cys 
    1445                 1450                 1455             


Ala Gly  Cys Gly Cys Cys Thr  Thr Cys Gly Cys Cys  Ala Cys Gly 
    1460                 1465                 1470             


Ala Cys  Cys Ala Ala Thr Ala  Gly Gly Ala Thr Gly  Gly Ala Gly 
    1475                 1480                 1485             


Cys Thr  Cys Gly Ala Gly Gly  Gly Cys Gly Cys Gly  Ala Gly Thr 
    1490                 1495                 1500             


Thr Ala  Cys Cys Ala Gly Gly  Thr Gly Cys Cys Cys  Cys Cys Gly 
    1505                 1510                 1515             


Cys Ala  Gly Cys Cys Gly Ala  Ala Cys Gly Gly Cys  Ala Thr Gly 
    1520                 1525                 1530             


Ala Cys  Cys Ala Ala Cys Ala  Ala Cys Cys Thr Cys  Cys Ala Gly 
    1535                 1540                 1545             


Gly Gly  Cys Ala Gly Cys Ala  Ala Cys Ala Cys Cys  Thr Ala Thr 
    1550                 1555                 1560             


Gly Cys  Cys Cys Thr Gly Gly  Ala Gly Ala Ala Cys  Ala Cys Thr 
    1565                 1570                 1575             


Ala Thr  Gly Ala Thr Cys Thr  Thr Cys Ala Ala Cys  Ala Gly Cys 
    1580                 1585                 1590             


Cys Ala  Gly Cys Cys Gly Gly  Cys Gly Ala Ala Cys  Cys Cys Gly 
    1595                 1600                 1605             


Gly Gly  Cys Ala Cys Cys Ala  Cys Cys Gly Cys Cys  Ala Cys Gly 
    1610                 1615                 1620             


Thr Ala  Cys Cys Thr Cys Gly  Ala Gly Gly Gly Cys  Ala Ala Cys 
    1625                 1630                 1635             


Ala Thr  Gly Cys Thr Cys Ala  Thr Cys Ala Cys Cys  Ala Gly Cys 
    1640                 1645                 1650             


Gly Ala  Gly Ala Gly Cys Gly  Ala Gly Ala Cys Gly  Cys Ala Gly 
    1655                 1660                 1665             


Cys Cys  Gly Gly Thr Gly Ala  Ala Cys Cys Gly Cys  Gly Thr Gly 
    1670                 1675                 1680             


Gly Cys  Gly Thr Ala Cys Ala  Ala Cys Gly Thr Cys  Gly Gly Cys 
    1685                 1690                 1695             


Gly Gly  Gly Cys Ala Gly Ala  Thr Gly Gly Cys Cys  Ala Cys Cys 
    1700                 1705                 1710             


Ala Ala  Cys Ala Ala Cys Cys  Ala Gly Ala Gly Cys  Thr Cys Cys 
    1715                 1720                 1725             


Ala Cys  Cys Ala Cys Thr Gly  Cys Cys Cys Cys Cys  Gly Cys Gly 
    1730                 1735                 1740             


Ala Cys  Cys Gly Gly Cys Ala  Cys Gly Thr Ala Cys  Ala Ala Cys 
    1745                 1750                 1755             


Cys Thr  Cys Cys Ala Gly Gly  Ala Ala Ala Thr Cys  Gly Thr Gly 
    1760                 1765                 1770             


Cys Cys  Cys Gly Gly Cys Ala  Gly Cys Gly Thr Gly  Thr Gly Gly 
    1775                 1780                 1785             


Ala Thr  Gly Gly Ala Gly Ala  Gly Gly Gly Ala Cys  Gly Thr Gly 
    1790                 1795                 1800             


Thr Ala  Cys Cys Thr Cys Cys  Ala Ala Gly Gly Ala  Cys Cys Cys 
    1805                 1810                 1815             


Ala Thr  Cys Thr Gly Gly Gly  Cys Cys Ala Ala Gly  Ala Thr Cys 
    1820                 1825                 1830             


Cys Cys  Ala Gly Ala Gly Ala  Cys Gly Gly Gly Gly  Gly Cys Gly 
    1835                 1840                 1845             


Cys Ala  Cys Thr Thr Thr Cys  Ala Cys Cys Cys Cys  Thr Cys Thr 
    1850                 1855                 1860             


Cys Cys  Gly Gly Cys Cys Ala  Thr Gly Gly Gly Cys  Gly Gly Ala 
    1865                 1870                 1875             


Thr Thr  Cys Gly Gly Ala Cys  Thr Cys Ala Ala Ala  Cys Ala Cys 
    1880                 1885                 1890             


Cys Cys  Ala Cys Cys Gly Cys  Cys Cys Ala Thr Gly  Ala Thr Gly 
    1895                 1900                 1905             


Cys Thr  Cys Ala Thr Cys Ala  Ala Gly Ala Ala Cys  Ala Cys Gly 
    1910                 1915                 1920             


Cys Cys  Thr Gly Thr Gly Cys  Cys Cys Gly Gly Ala  Ala Ala Thr 
    1925                 1930                 1935             


Ala Thr  Cys Ala Cys Cys Ala  Gly Cys Thr Thr Cys  Thr Cys Gly 
    1940                 1945                 1950             


Gly Ala  Cys Gly Thr Gly Cys  Cys Cys Gly Thr Cys  Ala Gly Cys 
    1955                 1960                 1965             


Ala Gly  Cys Thr Thr Cys Ala  Thr Cys Ala Cys Cys  Cys Ala Gly 
    1970                 1975                 1980             


Thr Ala  Cys Ala Gly Cys Ala  Cys Cys Gly Gly Gly  Cys Ala Gly 
    1985                 1990                 1995             


Gly Thr  Cys Ala Cys Cys Gly  Thr Gly Gly Ala Gly  Ala Thr Gly 
    2000                 2005                 2010             


Gly Ala  Gly Thr Gly Gly Gly  Ala Gly Cys Thr Cys  Ala Ala Gly 
    2015                 2020                 2025             


Ala Ala  Gly Gly Ala Ala Ala  Ala Cys Thr Cys Cys  Ala Ala Gly 
    2030                 2035                 2040             


Ala Gly  Gly Thr Gly Gly Ala  Ala Cys Cys Cys Ala  Gly Ala Gly 
    2045                 2050                 2055             


Ala Thr  Cys Cys Ala Gly Thr  Ala Cys Ala Cys Ala  Ala Ala Cys 
    2060                 2065                 2070             


Ala Ala  Cys Thr Ala Cys Ala  Ala Cys Gly Ala Cys  Cys Cys Cys 
    2075                 2080                 2085             


Cys Ala  Gly Thr Thr Thr Gly  Thr Gly Gly Ala Cys  Thr Thr Thr 
    2090                 2095                 2100             


Gly Cys  Cys Cys Cys Gly Gly  Ala Cys Ala Gly Cys  Ala Cys Cys 
    2105                 2110                 2115             


Gly Gly  Gly Gly Ala Ala Thr  Ala Cys Ala Gly Ala  Ala Cys Cys 
    2120                 2125                 2130             


Ala Cys  Cys Ala Gly Ala Cys  Cys Thr Ala Thr Cys  Gly Gly Ala 
    2135                 2140                 2145             


Ala Cys  Cys Cys Gly Ala Thr  Ala Cys Cys Thr Thr  Ala Cys Cys 
    2150                 2155                 2160             


Cys Gly  Ala Cys Cys Cys Cys  Thr Thr Thr Ala Ala  
    2165                 2170                 2175 


<210>  36
<211>  724
<212>  PRT
<213>  Adeno-associated virus

<400>  36

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  37
<211>  588
<212>  PRT
<213>  Adeno-associated virus

<400>  37

Thr Ala Pro Thr Gly Lys Arg Ile Asp Asp His Phe Pro Lys Arg Lys 
1               5                   10                  15      


Lys Ala Arg Thr Glu Glu Asp Ser Lys Pro Ser Thr Ser Ser Asp Ala 
            20                  25                  30          


Glu Ala Gly Pro Ser Gly Ser Gln Gln Leu Gln Ile Pro Ala Gln Pro 
        35                  40                  45              


Ala Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Gly Pro 
    50                  55                  60                  


Leu Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly 
65                  70                  75                  80  


Asp Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Val Thr Lys 
                85                  90                  95      


Ser Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Arg 
            100                 105                 110         


Glu Ile Lys Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe 
        115                 120                 125             


Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser 
    130                 135                 140                 


His Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly 
145                 150                 155                 160 


Phe Arg Pro Arg Ser Leu Arg Val Lys Ile Phe Asn Ile Gln Val Lys 
                165                 170                 175     


Glu Val Thr Val Gln Asp Ser Thr Thr Thr Ile Ala Asn Asn Leu Thr 
            180                 185                 190         


Ser Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val 
        195                 200                 205             


Val Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val 
    210                 215                 220                 


Phe Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asp Asn Thr 
225                 230                 235                 240 


Glu Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro 
                245                 250                 255     


Ser Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Asn Phe 
            260                 265                 270         


Glu Glu Val Pro Phe His Ser Ser Phe Ala Pro Ser Gln Asn Leu Phe 
        275                 280                 285             


Lys Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser 
    290                 295                 300                 


Thr Asn Asn Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly Arg 
305                 310                 315                 320 


Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg Thr 
                325                 330                 335     


Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser Ala 
            340                 345                 350         


Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln Val 
        355                 360                 365             


Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn Thr 
    370                 375                 380                 


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn Pro 
385                 390                 395                 400 


Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser Glu 
                405                 410                 415     


Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly Gln 
            420                 425                 430         


Met Ala Thr Asn Asn Gln Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr 
        435                 440                 445             


Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg Asp 
    450                 455                 460                 


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
465                 470                 475                 480 


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
                485                 490                 495     


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile Thr 
            500                 505                 510         


Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr 
        515                 520                 525             


Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser 
    530                 535                 540                 


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro 
545                 550                 555                 560 


Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr 
                565                 570                 575     


Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
            580                 585             


<210>  38
<211>  532
<212>  PRT
<213>  Adeno-associated virus

<400>  38

Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
        35                  40                  45              


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
    50                  55                  60                  


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
65                  70                  75                  80  


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
                85                  90                  95      


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
            100                 105                 110         


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
        115                 120                 125             


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
    130                 135                 140                 


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
145                 150                 155                 160 


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
                165                 170                 175     


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
            180                 185                 190         


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
        195                 200                 205             


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
    210                 215                 220                 


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
225                 230                 235                 240 


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
                245                 250                 255     


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
            260                 265                 270         


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
        275                 280                 285             


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
    290                 295                 300                 


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
305                 310                 315                 320 


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
                325                 330                 335     


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
            340                 345                 350         


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
        355                 360                 365             


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
    370                 375                 380                 


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
385                 390                 395                 400 


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
                405                 410                 415     


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
            420                 425                 430         


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
        435                 440                 445             


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
    450                 455                 460                 


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
465                 470                 475                 480 


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
                485                 490                 495     


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
            500                 505                 510         


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
        515                 520                 525             


Thr Arg Pro Leu 
    530         


<210>  39
<211>  1578
<212>  DNA
<213>  Macaca mulatta

<400>  39
atggcgggca tctggctggg gctcgtgtgg cagaagctgc tgctgtgggg cgcggcgagt       60

gccgtgtccc tggccggcgc cagtctggtc ctgagcctgc tgcagagggt ggcgagctac      120

gtgaggaaat ggcagcagat gcggcccatc cccacggtgg cccgcgccta cccactggtg      180

ggccacgcgc tgctgatgaa gcgggacggg cgagaatttt ttcagcagat cattgagtac      240

acagaggaat accgccacat gccactcctg aagctctggg tcgggccggt gcccatggtg      300

gccctttata atgcagaaaa tgtggaggta attttaacta gttcaaagca aattgacaaa      360

tcctctatgt acaagttttt agaaccatgg cttggcctag gacttcttac aagtactgga      420

aacaaatggc gctccaggag aaagatgtta acacccactt tccattttac cattctggaa      480

gatttcttag atatcatgaa tgaacaagca aatatattgg ttaagaaact tgaaaaacat      540

gttaaccaag aagcatttaa ctgctttgtt tacatcactc tttgtgcctt agatatcatc      600

tgtgaaacag ctatggggaa gaatattggt gctcaaagta acgatgattc cgagtatgtc      660

cgtgcagttt atagaatgag tgagatgata tttcgaagaa taaagatgcc gtggctttgg      720

cttgacctct ggtaccttat gtttaaagag ggatgggaac acaaaaagag ccttaagatc      780

ctacatgctt ttaccaacaa tgttatcgct gaacgggcca atgaaatgaa cgtggatgaa      840

gactgtagag gtgatggcag ggactccgcc ccctccaaaa ataaacgcag ggcctttctt      900

gacttgcttt taagtgtgac tgacgacgaa gggaacaggc taagtcatga agatattcga      960

gaagaagttg acaccttcat gtttgagggc cacgacacaa ctgcagctgc aatgaactgg     1020

tccttatacc tgttggggtc taacccagaa gtccagaaaa aagtggacca tgaactggat     1080

gacgtgtttg ggaggtctga ccgtcccgct actgtagaag acctgaagaa acttcggtat     1140

ctggaatgtg ttattaagga gacccttcgc ctttttcctt ctgttccttt atttgcccgc     1200

agtgttagtg aagattgtga agtggcaggt tacagagttc tgaaaggcac tgaagccgtc     1260

atcattccct atgcattgca tagagatcca agatacttcc ccaaccctga ggagttccgg     1320

cctgagcggt tcttccccga gaatgcacaa gggcgccatc catatgccta cgtgcccttc     1380

tctgctggcc ccaggaactg tataggtcaa aagtttgctg tgatggaaga aaagaccatt     1440

ctttcgtgca tcctaaggca cttttggata gaatccaacc agaaaagaga agaacttggt     1500

ctagaaggac agttgattct tcgtccaact aatggcatct ggatcaagtt gaagaggaga     1560

aatgcagatg aaccctaa                                                   1578


<210>  40
<211>  525
<212>  PRT
<213>  Macaca mulatta

<400>  40

Met Ala Gly Ile Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Val Ser Leu Ala Gly Ala Ser Leu Val Leu Ser 
            20                  25                  30          


Leu Leu Gln Arg Val Ala Ser Tyr Val Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Leu Met Lys Arg Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr 
65                  70                  75                  80  


Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro 
                85                  90                  95      


Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Leu Glu Lys His Val Asn Gln Glu Ala Phe Asn Cys Phe Val Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys 
                245                 250                 255     


Ser Leu Lys Ile Leu His Ala Phe Thr Asn Asn Val Ile Ala Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Asn Val Asp Glu Asp Cys Arg Gly Asp Gly Arg Asp 
        275                 280                 285             


Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Met Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Lys Lys Val Asp His Glu Leu Asp Asp Val Phe Gly Arg Ser Asp Arg 
        355                 360                 365             


Pro Ala Thr Val Glu Asp Leu Lys Lys Leu Arg Tyr Leu Glu Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Val Ser Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asn Pro Glu Glu Phe Arg Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ala Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Cys Ile Leu Arg His Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Glu Gly Gln Leu Ile Leu Arg Pro Thr Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Glu Pro 
        515                 520                 525 


<210>  41
<211>  1584
<212>  DNA
<213>  Bos taurus

<400>  41
atgctggcgc cgtggttgct gagcgtcggg ccgaagctgc tgctctggag cgggctgtgc       60

gccgtctccc tggcaggcgc caccctcacc ctgaacctcc tgaagatggt ggcgagctat      120

gcgcggaaat ggcgtcagat gcgtcccgtc ccgaccattg gggaccccta ccccttggtg      180

ggacacgcgc tgatgatgaa gcccgatgca agagattttt ttcagcagat aattgatttc      240

actgaagaat gccgacacct gccactgctg aaactctggc tcgggcctgt gcctctcgtg      300

gccctttata acgcagaaac tgtggaagta attttaagca gttcaaagca cattgaaaaa      360

tcctatatgt acaagttctt agaaccgtgg cttggactag gacttcttac aagtactgga      420

aacaaatggc gatctaggag aaaaatgtta acacccactt tccattttac aattctggag      480

gatttcttag atgtcatgaa tgaacaagca aatatattgg ttactaagct tgaaaagcat      540

gttaaccaag aagcgtttaa ctgctttttt tacgtcactc tttgtacctt agatataatc      600

tgtgaaacag ctatgggaaa gaacattggt gctcaaagaa atgatgattc cgagtatgtt      660

cgagccgttt ataggatgag tgattcgata catcaaagaa tgaagatgcc ctggctctgg      720

cttgacctta tattctatat gtttaaaaat ggacgagaac acagaaggag cctaaagatt      780

gtacatgatt ttaccaacaa tgtcatcact gaacgggcca atgaaatgaa gagacatgaa      840

gaaggtacga gtaacgacaa ggagaaggac tttcctccac gcaaaactaa atgcagggct      900

tttcttgact tgcttttaaa tgtgactgat gaccaaggga acaagctgag tcatgaagat      960

ataagagaag aagtcgacac ctttatgttt gagggccatg atacaactgc agctgcaata     1020

aactggtcct tgtatctgtt gggttggtat ccagaagtcc agcagagagt ggacactgag     1080

ctggaagaag tgtttgggaa gtctgaccgt cctgttaccc tagaagacct gaagaaactt     1140

aaatatctgg actgtgttat taaggagagc cttcgccttt tcccgtctgt tcctttcttt     1200

gcccgtaatc ttaccgaaga ctgtgaagtt gcgggtcaca aaatcgtgca aggctgtcaa     1260

gtaatcattg tgccctacgc actgcataga gatccaaagt acttcccgga tcctgaggaa     1320

ttcaagccag aacggttctt tcccgagaat ttgaaaggac gtcatacata cgcatatgtg     1380

cccttctctg caggcccccg aaactgtata ggtcaaaagt ttgccataat ggaagaaaag     1440

accattcttt cctgcatcct taggcacttt tgggtagaat ccaaccaaaa aagagaagaa     1500

cttggtctag caggagagct cattcttcgt ccaagtaacg gcatctggat caagttgaag     1560

aggagaaaca cagatgaatc ctaa                                            1584


<210>  42
<211>  527
<212>  PRT
<213>  Bos taurus

<400>  42

Met Leu Ala Pro Trp Leu Leu Ser Val Gly Pro Lys Leu Leu Leu Trp 
1               5                   10                  15      


Ser Gly Leu Cys Ala Val Ser Leu Ala Gly Ala Thr Leu Thr Leu Asn 
            20                  25                  30          


Leu Leu Lys Met Val Ala Ser Tyr Ala Arg Lys Trp Arg Gln Met Arg 
        35                  40                  45              


Pro Val Pro Thr Ile Gly Asp Pro Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Met Met Lys Pro Asp Ala Arg Asp Phe Phe Gln Gln Ile Ile Asp Phe 
65                  70                  75                  80  


Thr Glu Glu Cys Arg His Leu Pro Leu Leu Lys Leu Trp Leu Gly Pro 
                85                  90                  95      


Val Pro Leu Val Ala Leu Tyr Asn Ala Glu Thr Val Glu Val Ile Leu 
            100                 105                 110         


Ser Ser Ser Lys His Ile Glu Lys Ser Tyr Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Val Met Asn Glu Gln Ala Asn Ile Leu Val Thr Lys 
                165                 170                 175     


Leu Glu Lys His Val Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Val 
            180                 185                 190         


Thr Leu Cys Thr Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Arg Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Asp Ser Ile His Gln Arg Met Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Ile Phe Tyr Met Phe Lys Asn Gly Arg Glu His Arg Arg 
                245                 250                 255     


Ser Leu Lys Ile Val His Asp Phe Thr Asn Asn Val Ile Thr Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Lys Arg His Glu Glu Gly Thr Ser Asn Asp Lys Glu 
        275                 280                 285             


Lys Asp Phe Pro Pro Arg Lys Thr Lys Cys Arg Ala Phe Leu Asp Leu 
    290                 295                 300                 


Leu Leu Asn Val Thr Asp Asp Gln Gly Asn Lys Leu Ser His Glu Asp 
305                 310                 315                 320 


Ile Arg Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr 
                325                 330                 335     


Ala Ala Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Trp Tyr Pro Glu 
            340                 345                 350         


Val Gln Gln Arg Val Asp Thr Glu Leu Glu Glu Val Phe Gly Lys Ser 
        355                 360                 365             


Asp Arg Pro Val Thr Leu Glu Asp Leu Lys Lys Leu Lys Tyr Leu Asp 
    370                 375                 380                 


Cys Val Ile Lys Glu Ser Leu Arg Leu Phe Pro Ser Val Pro Phe Phe 
385                 390                 395                 400 


Ala Arg Asn Leu Thr Glu Asp Cys Glu Val Ala Gly His Lys Ile Val 
                405                 410                 415     


Gln Gly Cys Gln Val Ile Ile Val Pro Tyr Ala Leu His Arg Asp Pro 
            420                 425                 430         


Lys Tyr Phe Pro Asp Pro Glu Glu Phe Lys Pro Glu Arg Phe Phe Pro 
        435                 440                 445             


Glu Asn Leu Lys Gly Arg His Thr Tyr Ala Tyr Val Pro Phe Ser Ala 
    450                 455                 460                 


Gly Pro Arg Asn Cys Ile Gly Gln Lys Phe Ala Ile Met Glu Glu Lys 
465                 470                 475                 480 


Thr Ile Leu Ser Cys Ile Leu Arg His Phe Trp Val Glu Ser Asn Gln 
                485                 490                 495     


Lys Arg Glu Glu Leu Gly Leu Ala Gly Glu Leu Ile Leu Arg Pro Ser 
            500                 505                 510         


Asn Gly Ile Trp Ile Lys Leu Lys Arg Arg Asn Thr Asp Glu Ser 
        515                 520                 525         


<210>  43
<211>  1578
<212>  DNA
<213>  Rattus norvegicus

<400>  43
atgttgtggc tgtggttagg gctcagcggg cagaagctat tgctttgggg cgcagcgagc       60

gcggtctccg tggccggcgc cactgtcttg ctcaacatcc tgcagatgtt ggtaagctat      120

gcacgaaagt ggcagcagat gcggccaatc ccgtcggtgg ctcgcgctta ccccttggtg      180

ggacatgcgc tgtttatgaa gcccaacaac acagaatttt ttcagcagat aattcagtac      240

acagaagaat tccgacacct gcccatcatt aaactctgga ttggaccagt gcccctggtg      300

gcactttata aggcagagaa tgtggaggtg attttgacca gttcgaagca aattgataaa      360

tcctttatgt acaagttcct acagccatgg ctgggactag gacttcttac aagtactggg      420

agcaaatggc gtgccaggag gaagatgtta acacccagtt tccattttac aattctggag      480

gatttcttag atgtcatgaa tgagcaagca aatatattgg ttaacaagct tgaaaaacat      540

gtcaatcaag aggcctttaa ctgctttttc cccatcactc tttgtgctct ggatataatc      600

tgtgaaacgg ctatggggaa gaacattgga gctcaaagta atggtgattc tgagtatgtc      660

cgtacagtgt ataggatgag cgatatgata tacagaagaa tgaagatgcc ctggttttgg      720

tttgaccttt ggtaccttat gtttaaagaa ggaagggacc acaaaaaggg actaaagagt      780

ctacatactt ttaccaacaa tgtcattgct gaacgggtta atgcaaggaa ggcagagcaa      840

gactgcatag gtgctgggag gggtcctctc ccctcgaaaa ctaagcgcaa ggcctttctt      900

gacttgcttt tgagtgtgac tgatgaggaa ggaaacaaat taagccatga agacatccga      960

gaggaagttg acaccttcat gtttgagggt cacgatacaa ctgctgctgc cataaactgg     1020

tccttatacc tcctgggctc taatccagaa gtccagagga aagtggacaa ggagctggat     1080

gatgtgtttg gaagatccca tcgccctgtc accttggaag acctgaagaa acttaaatat     1140

ctggattgtg tcattaagga gaccctccgt gttttcccat ctgtcccttt atttgcccgg     1200

agtcttagcg aagactgtga agtggcgggt tacaaaatct caaaaggaac ggaagcagtc     1260

atcattccct atgcactaca tcgagaccct agatacttcc cagaccctga ggaattccag     1320

ccagagcggt tctttcctga aaactcccaa ggacgccacc cctatgccta tgtgccattc     1380

tctgctggac ctagaaactg cattggtcaa aagtttgcgg tcatggagga aaagaccatt     1440

cttgcctgta tcctgaggga gttttggata gaatccaacc agaagagaga agaactcggc     1500

ctggctggag atttgattct taggccaaat aatggcatct ggatcaagct gaagaggagg     1560

catgaagatg acccctaa                                                   1578


<210>  44
<211>  525
<212>  PRT
<213>  Rattus norvegicus

<400>  44

Met Leu Trp Leu Trp Leu Gly Leu Ser Gly Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Val Ser Val Ala Gly Ala Thr Val Leu Leu Asn 
            20                  25                  30          


Ile Leu Gln Met Leu Val Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Ser Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Phe Met Lys Pro Asn Asn Thr Glu Phe Phe Gln Gln Ile Ile Gln Tyr 
65                  70                  75                  80  


Thr Glu Glu Phe Arg His Leu Pro Ile Ile Lys Leu Trp Ile Gly Pro 
                85                  90                  95      


Val Pro Leu Val Ala Leu Tyr Lys Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Phe Met Tyr Lys Phe Leu Gln 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Ser Lys Trp Arg 
    130                 135                 140                 


Ala Arg Arg Lys Met Leu Thr Pro Ser Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Val Met Asn Glu Gln Ala Asn Ile Leu Val Asn Lys 
                165                 170                 175     


Leu Glu Lys His Val Asn Gln Glu Ala Phe Asn Cys Phe Phe Pro Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Gly Asp Ser Glu Tyr Val Arg Thr Val Tyr 
    210                 215                 220                 


Arg Met Ser Asp Met Ile Tyr Arg Arg Met Lys Met Pro Trp Phe Trp 
225                 230                 235                 240 


Phe Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Arg Asp His Lys Lys 
                245                 250                 255     


Gly Leu Lys Ser Leu His Thr Phe Thr Asn Asn Val Ile Ala Glu Arg 
            260                 265                 270         


Val Asn Ala Arg Lys Ala Glu Gln Asp Cys Ile Gly Ala Gly Arg Gly 
        275                 280                 285             


Pro Leu Pro Ser Lys Thr Lys Arg Lys Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Glu Glu Gly Asn Lys Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Arg Lys Val Asp Lys Glu Leu Asp Asp Val Phe Gly Arg Ser His Arg 
        355                 360                 365             


Pro Val Thr Leu Glu Asp Leu Lys Lys Leu Lys Tyr Leu Asp Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Val Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Leu Ser Glu Asp Cys Glu Val Ala Gly Tyr Lys Ile Ser Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asp Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ser Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ala Cys Ile Leu Arg Glu Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Ala Gly Asp Leu Ile Leu Arg Pro Asn Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg His Glu Asp Asp Pro 
        515                 520                 525 


<210>  45
<211>  1578
<212>  DNA
<213>  Mus musculus

<400>  45
atgttgtggc tgtggttagg gctcagtggg cagaaactat tgctttgggg cgcagcgagc       60

gcggtctccc tggccggcgc cactatcctg atcagcatct ttccgatgct ggtaagctac      120

gcgcggaaat ggcagcagat gcggtcaatc ccgtcggtgg cccgcgccta ccccttggtg      180

ggacacgcgc tttatatgaa gcccaacaac gcagaatttt ttcagcagct aatttattac      240

acagaagaat ttcgacacct gccgatcatt aaactttgga ttggacccgt gcccctggtg      300

gcactttata aggcagagaa tgtggaggtg attttgacca gttctaagca aattgataaa      360

tcgtttttgt acaagttcct acagccatgg ctgggactag gacttcttac aagtacgggg      420

agcaaatggc gcaccaggag gaagatgcta acgcccactt tccattttac cattctggag      480

aacttcttgg atgtcatgaa tgagcaagca aatatattgg ttaataagct tgaaaaacac      540

gtcaaccaag aagcctttaa ttgttttttt tacatcactc tttgtgctct ggatataatc      600

tgtgaaacgg ctatggggaa gaacatcgga gctcaaagca ataatgattc cgagtatgtc      660

cgtacagtgt ataggatgag tgatatgata tatagaagaa tgaagatgcc ctggctttgg      720

tttgaccttt ggtaccttgt gtttaaagaa ggacgggacc acaaaagggg actcaaatgc      780

ctacatactt tcaccaacaa tgtcattgct gaacgagtca aagaaaggaa ggcagaggaa      840

gactggacgg gtgctggcag gggtcctatc ccctccaaaa ataagcgcaa ggctttcctt      900

gacttgcttt tgagtgtgac tgatgaggaa ggaaacagat taagccagga agacatccga      960

gaggaagttg acaccttcat gtttgagggt cacgatacaa ctgctgctgc aatcaactgg     1020

tccttatacc tattgggcac gaatccagaa gtccagagga aagtggatca ggagctggat     1080

gaagtgtttg gaagatccca tcgtcctgtc accttggaag acctgaagaa acttaaatat     1140

ttggattgcg tcattaagga gactctccga gttttcccat ctgtcccttt atttgcccgg     1200

agtcttagcg aggactgtga agtgggcggt tacaaagtca caaaaggaac ggaagcaatc     1260

atcattccct acgcactaca ccgagacccc agatacttcc cagatccaga ggaattccga     1320

ccagagcggt tctttcctga aaattcccaa ggacgccatc cctatgccta tgtgccattt     1380

tctgctggac ctcgaaactg tattggtcaa aagtttgctg tcatggagga gaagaccatt     1440

cttgcctgta tcctgaggca gttttgggta gaatccaacc agaagagaga agaactcggc     1500

ctggctggag atttgattct taggccaaat aatggcatct ggatcaagct gaagaggaga     1560

catgaagatg acccctaa                                                   1578


<210>  46
<211>  525
<212>  PRT
<213>  Mus musculus

<400>  46

Met Leu Trp Leu Trp Leu Gly Leu Ser Gly Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Val Ser Leu Ala Gly Ala Thr Ile Leu Ile Ser 
            20                  25                  30          


Ile Phe Pro Met Leu Val Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Ser Ile Pro Ser Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Tyr Met Lys Pro Asn Asn Ala Glu Phe Phe Gln Gln Leu Ile Tyr Tyr 
65                  70                  75                  80  


Thr Glu Glu Phe Arg His Leu Pro Ile Ile Lys Leu Trp Ile Gly Pro 
                85                  90                  95      


Val Pro Leu Val Ala Leu Tyr Lys Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Phe Leu Tyr Lys Phe Leu Gln 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Ser Lys Trp Arg 
    130                 135                 140                 


Thr Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asn Phe Leu Asp Val Met Asn Glu Gln Ala Asn Ile Leu Val Asn Lys 
                165                 170                 175     


Leu Glu Lys His Val Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asn Asp Ser Glu Tyr Val Arg Thr Val Tyr 
    210                 215                 220                 


Arg Met Ser Asp Met Ile Tyr Arg Arg Met Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Phe Asp Leu Trp Tyr Leu Val Phe Lys Glu Gly Arg Asp His Lys Arg 
                245                 250                 255     


Gly Leu Lys Cys Leu His Thr Phe Thr Asn Asn Val Ile Ala Glu Arg 
            260                 265                 270         


Val Lys Glu Arg Lys Ala Glu Glu Asp Trp Thr Gly Ala Gly Arg Gly 
        275                 280                 285             


Pro Ile Pro Ser Lys Asn Lys Arg Lys Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Glu Glu Gly Asn Arg Leu Ser Gln Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Thr Asn Pro Glu Val Gln 
            340                 345                 350         


Arg Lys Val Asp Gln Glu Leu Asp Glu Val Phe Gly Arg Ser His Arg 
        355                 360                 365             


Pro Val Thr Leu Glu Asp Leu Lys Lys Leu Lys Tyr Leu Asp Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Val Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Leu Ser Glu Asp Cys Glu Val Gly Gly Tyr Lys Val Thr Lys Gly 
                405                 410                 415     


Thr Glu Ala Ile Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asp Pro Glu Glu Phe Arg Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ser Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ala Cys Ile Leu Arg Gln Phe Trp Val Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Ala Gly Asp Leu Ile Leu Arg Pro Asn Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg His Glu Asp Asp Pro 
        515                 520                 525 


<210>  47
<211>  1593
<212>  DNA
<213>  Gallus gallus

<400>  47
atggcaatgg agatcacgct aggatccatg gagggaacac agctgctgcc ctgggtggct       60

ggagccatca ccctgctgct gacggtggtg actgtacact tcctaccctc tttgctgaac      120

tactggtggt ggtggtgggt gatgaagccc atcccaggca tccgcccatg ctaccccttt      180

gtgggaaatg ctctcctgtt ggagcgaaat ggagaaggtt tttttaaaca gctacaacag      240

tatgctgatg agttcaggaa aatgccaatg ttcaaactct ggttaggtcc actgcctgtc      300

acagtattgt tccatcctga tagtgtggag gttattctga gcagttcaaa gcatattaaa      360

aaatcattcc tgtacacatt tctgcaccca tggctgggga ctggactttt gacaagcact      420

ggagacaagt ggcggtcacg gaggaagatg ataactccta cattccactt tgcaatctta      480

aatgactttc ttgaggttat gaatgaacaa gggggtgttt tgttggagaa acttgagaag      540

catgttgaca aggaaccatt taatatcttt acagacatca ctctgtgtgc acttgatatt      600

atctgtgaaa ctgcaatggg caagaatctg ggtgctcaag acaataagga ttctgagtat      660

gttcgtgctg tctacaggat gagtgatcta atccaacagc gacagaagag cccttggctt      720

tggcatgatc ttatgtatct tctgttcaag gaaggaagag agcatgagcg gaatcttaag      780

attctgcatg gttttacaga tacggtaatt gcagaaaaag ttgcagaact tgaaaacacc      840

aagctaacaa aacacgatac tgacgtgaac actgaagaag aaagtggttc caaaaagaga      900

gaagctttct tagacatgct gctgaatgcc acagatgatg aagggaaaaa actcagctac      960

aaggacattc gtgaagaagt ggatactttt atgtttgagg gtcatgatac aacagcagct     1020

gctatgaact gggtcctata cttgcttggt catcatcctg aagcccagaa gaaggttcac     1080

caagaactgg atgaggtgtt tggcaacaca gagcgtcctg ttacagtgga tgatttgaag     1140

aaacttcgat acctcgagtg tgttgtgaaa gaagccctga ggctcttccc ttcagttccc     1200

atgttcgccc gttccttgca agaggattgc tacattagtg gatataagct accaaaaggc     1260

acgaatgtcc ttgtcttaac ttatgtgctg cacagagatc ctgagatctt ccctgagcca     1320

gatgaattca ggcctgagcg cttcttccct gaaaatagca aaggaaggca cccatatgct     1380

tatgtgccct tctctgctgg ccccaggaac tgcattggcc aacgctttgc acaaatggaa     1440

gagaaaactc ttctagccct catcctgcgg cgcttttggg tggactgttc tcaaaagcca     1500

gaagagcttg gtctgtcagg agaactaatt cttcgtccaa ataatggcat ctgggttcaa     1560

ctgaagagga gaccaaaaac tgtaacagaa tga                                  1593


<210>  48
<211>  530
<212>  PRT
<213>  Gallus gallus

<400>  48

Met Ala Met Glu Ile Thr Leu Gly Ser Met Glu Gly Thr Gln Leu Leu 
1               5                   10                  15      


Pro Trp Val Ala Gly Ala Ile Thr Leu Leu Leu Thr Val Val Thr Val 
            20                  25                  30          


His Phe Leu Pro Ser Leu Leu Asn Tyr Trp Trp Trp Trp Trp Val Met 
        35                  40                  45              


Lys Pro Ile Pro Gly Ile Arg Pro Cys Tyr Pro Phe Val Gly Asn Ala 
    50                  55                  60                  


Leu Leu Leu Glu Arg Asn Gly Glu Gly Phe Phe Lys Gln Leu Gln Gln 
65                  70                  75                  80  


Tyr Ala Asp Glu Phe Arg Lys Met Pro Met Phe Lys Leu Trp Leu Gly 
                85                  90                  95      


Pro Leu Pro Val Thr Val Leu Phe His Pro Asp Ser Val Glu Val Ile 
            100                 105                 110         


Leu Ser Ser Ser Lys His Ile Lys Lys Ser Phe Leu Tyr Thr Phe Leu 
        115                 120                 125             


His Pro Trp Leu Gly Thr Gly Leu Leu Thr Ser Thr Gly Asp Lys Trp 
    130                 135                 140                 


Arg Ser Arg Arg Lys Met Ile Thr Pro Thr Phe His Phe Ala Ile Leu 
145                 150                 155                 160 


Asn Asp Phe Leu Glu Val Met Asn Glu Gln Gly Gly Val Leu Leu Glu 
                165                 170                 175     


Lys Leu Glu Lys His Val Asp Lys Glu Pro Phe Asn Ile Phe Thr Asp 
            180                 185                 190         


Ile Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys 
        195                 200                 205             


Asn Leu Gly Ala Gln Asp Asn Lys Asp Ser Glu Tyr Val Arg Ala Val 
    210                 215                 220                 


Tyr Arg Met Ser Asp Leu Ile Gln Gln Arg Gln Lys Ser Pro Trp Leu 
225                 230                 235                 240 


Trp His Asp Leu Met Tyr Leu Leu Phe Lys Glu Gly Arg Glu His Glu 
                245                 250                 255     


Arg Asn Leu Lys Ile Leu His Gly Phe Thr Asp Thr Val Ile Ala Glu 
            260                 265                 270         


Lys Val Ala Glu Leu Glu Asn Thr Lys Leu Thr Lys His Asp Thr Asp 
        275                 280                 285             


Val Asn Thr Glu Glu Glu Ser Gly Ser Lys Lys Arg Glu Ala Phe Leu 
    290                 295                 300                 


Asp Met Leu Leu Asn Ala Thr Asp Asp Glu Gly Lys Lys Leu Ser Tyr 
305                 310                 315                 320 


Lys Asp Ile Arg Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp 
                325                 330                 335     


Thr Thr Ala Ala Ala Met Asn Trp Val Leu Tyr Leu Leu Gly His His 
            340                 345                 350         


Pro Glu Ala Gln Lys Lys Val His Gln Glu Leu Asp Glu Val Phe Gly 
        355                 360                 365             


Asn Thr Glu Arg Pro Val Thr Val Asp Asp Leu Lys Lys Leu Arg Tyr 
    370                 375                 380                 


Leu Glu Cys Val Val Lys Glu Ala Leu Arg Leu Phe Pro Ser Val Pro 
385                 390                 395                 400 


Met Phe Ala Arg Ser Leu Gln Glu Asp Cys Tyr Ile Ser Gly Tyr Lys 
                405                 410                 415     


Leu Pro Lys Gly Thr Asn Val Leu Val Leu Thr Tyr Val Leu His Arg 
            420                 425                 430         


Asp Pro Glu Ile Phe Pro Glu Pro Asp Glu Phe Arg Pro Glu Arg Phe 
        435                 440                 445             


Phe Pro Glu Asn Ser Lys Gly Arg His Pro Tyr Ala Tyr Val Pro Phe 
    450                 455                 460                 


Ser Ala Gly Pro Arg Asn Cys Ile Gly Gln Arg Phe Ala Gln Met Glu 
465                 470                 475                 480 


Glu Lys Thr Leu Leu Ala Leu Ile Leu Arg Arg Phe Trp Val Asp Cys 
                485                 490                 495     


Ser Gln Lys Pro Glu Glu Leu Gly Leu Ser Gly Glu Leu Ile Leu Arg 
            500                 505                 510         


Pro Asn Asn Gly Ile Trp Val Gln Leu Lys Arg Arg Pro Lys Thr Val 
        515                 520                 525             


Thr Glu 
    530 


<210>  49
<211>  1134
<212>  DNA
<213>  Canis lupus

<400>  49
atgttaacac ccactttcca ttttacgatt ctggaagatt tcttagatgt catgaatgaa       60

cacgcaaata tattggttaa taagcttgaa aaacatgtta accaagaagc atttaactgc      120

tttttttaca tcactctttg tgcattagat ataatttgtg aaacagctat ggggaagaat      180

attggggctc aaaataatga ggattctgag tatgttcgtg ccatctacag aatgagtgat      240

acgatacatc gaagaatgaa gatgccctgg ctctggcttg actttttgtt tcttatgttt      300

aaagaaggcc gggaacacaa aaggaaccta gagatcctac ataattttac caataatgtc      360

atcactgaac gggccagtga actgaagaga gacgaagaac atggaagtgc tgacaaggac      420

tgctccccct ccaaaaataa acgcagagct tttcttgact tgcttttaaa tgtgactgat      480

gatgaaggga acaagctacg tcatgaagat gttcgagaag aagttgacac cttcatgttt      540

gagggccatg atacgacagc agcggcgata aactggtcct tatatctctt gggttcttac      600

ccagaagtcc agaaacaagt ggacagtgaa ctggaggacg tgtttgggaa gtctgatcgt      660

cctgctacct tagaagacct gaagaaactc aaatacctgg agtgtgtcat taaggagagc      720

cttcgccttt ttccttcagt tcccttattt gcccgtaatc ttaacgaaga ttgtgtagtt      780

gcgggttaca aggttgtgaa aggctcccaa gcgatcatca ttccctacgc acttcataga      840

gatccaagat atttcccaaa tcccgaggag ttccagccag agcggttctt tcctgaaaat      900

ttgcaaggac gccacccata tgcatacatt cccttttctg ctggacccag aaactgtata      960

ggtcaaaggt ttgccataat ggaagaaaag actgttcttt cctgtgtcct gaggcatttt     1020

tgggtagaat ccaaccagaa aagagaagaa cttggtctgg caggagagtt gattcttcgt     1080

ccaactaatg gcatctggat caagttgaag aggagaaatg cagatgaatc ttaa           1134


<210>  50
<211>  377
<212>  PRT
<213>  Canis lupus

<400>  50

Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu Asp Phe Leu Asp 
1               5                   10                  15      


Val Met Asn Glu His Ala Asn Ile Leu Val Asn Lys Leu Glu Lys His 
            20                  25                  30          


Val Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile Thr Leu Cys Ala 
        35                  40                  45              


Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn Ile Gly Ala Gln 
    50                  55                  60                  


Asn Asn Glu Asp Ser Glu Tyr Val Arg Ala Ile Tyr Arg Met Ser Asp 
65                  70                  75                  80  


Thr Ile His Arg Arg Met Lys Met Pro Trp Leu Trp Leu Asp Phe Leu 
                85                  90                  95      


Phe Leu Met Phe Lys Glu Gly Arg Glu His Lys Arg Asn Leu Glu Ile 
            100                 105                 110         


Leu His Asn Phe Thr Asn Asn Val Ile Thr Glu Arg Ala Ser Glu Leu 
        115                 120                 125             


Lys Arg Asp Glu Glu His Gly Ser Ala Asp Lys Asp Cys Ser Pro Ser 
    130                 135                 140                 


Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu Asn Val Thr Asp 
145                 150                 155                 160 


Asp Glu Gly Asn Lys Leu Arg His Glu Asp Val Arg Glu Glu Val Asp 
                165                 170                 175     


Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala Ala Ile Asn Trp 
            180                 185                 190         


Ser Leu Tyr Leu Leu Gly Ser Tyr Pro Glu Val Gln Lys Gln Val Asp 
        195                 200                 205             


Ser Glu Leu Glu Asp Val Phe Gly Lys Ser Asp Arg Pro Ala Thr Leu 
    210                 215                 220                 


Glu Asp Leu Lys Lys Leu Lys Tyr Leu Glu Cys Val Ile Lys Glu Ser 
225                 230                 235                 240 


Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg Asn Leu Asn Glu 
                245                 250                 255     


Asp Cys Val Val Ala Gly Tyr Lys Val Val Lys Gly Ser Gln Ala Ile 
            260                 265                 270         


Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr Phe Pro Asn Pro 
        275                 280                 285             


Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn Leu Gln Gly Arg 
    290                 295                 300                 


His Pro Tyr Ala Tyr Ile Pro Phe Ser Ala Gly Pro Arg Asn Cys Ile 
305                 310                 315                 320 


Gly Gln Arg Phe Ala Ile Met Glu Glu Lys Thr Val Leu Ser Cys Val 
                325                 330                 335     


Leu Arg His Phe Trp Val Glu Ser Asn Gln Lys Arg Glu Glu Leu Gly 
            340                 345                 350         


Leu Ala Gly Glu Leu Ile Leu Arg Pro Thr Asn Gly Ile Trp Ile Lys 
        355                 360                 365             


Leu Lys Arg Arg Asn Ala Asp Glu Ser 
    370                 375         


<210>  51
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence

<400>  51
gccgcc                                                                   6


<210>  52
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence

<400>  52
gacacc                                                                   6


<210>  53
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence

<400>  53
gccacg                                                                   6


<210>  54
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta ITR

<400>  54
cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt       60

cgcccggcct cagtgagcga gcgagcgcgc agagagggag tgg                        103


