                         SEQUENCE LISTING

<110>  The University of Birmingham
 
<120>  ANTIGEN BINDING MOLECULES AND EPITOPES,
AND USES THEREOF

<130>  JA92146P.WOP

<140>  PCT/GB2020/050456
<141>  2020/02/26

<150>  GB 1902590.7
<151>  2019-02-26

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1

Glu Thr Tyr Ile His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  2

Arg Ile Asp Pro Ala Asp Val Tyr Gly Arg Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  3

Ser Tyr Gly Ser Ser Tyr Gly Ile Asp Tyr 
1               5                   10  


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  4

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  5

Tyr Thr Ser Thr Leu His Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  6

Gln Gln Gly Tyr Thr Leu Pro Trp Thr 
1               5                   


<210>  7
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<400>  7

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Glu Thr Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Asp Val Tyr Gly Arg Tyr Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Ser Ala Tyr Leu Gln Val Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Tyr Gly Ser Ser Tyr Gly Ile Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235                 240 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            260                 265                 270         


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        355                 360                 365             


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
385                 390                 395                 400 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
                405                 410                 415     


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            420                 425                 430         


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460         


<210>  8
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<400>  8

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Gly Tyr 
            100                 105                 110         


Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Val Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Ser Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Thr Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  9
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<400>  9
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gttcagctgc agcagtctgg ggcagagctt gtgaagccag gggcctcagt caagttgtcc      120

tgcacagctt ctggcttcaa cattaaagaa acctatatac actgggtaaa acagaggcct      180

gaacagggcc tggagtggat tggaaggatt gatcctgcgg atgtttatgg tagatatgac      240

ccgaagttcc agggcaaggc cactataaca gcagacacat cctccaattc agcctacctg      300

caggtcagca gcctgacatc tgaggacact gccgtctatt actgtgctag atcctacggt      360

agtagctatg gtattgacta ctggggtcaa ggaacctcag tcaccgtctc ctcagccaaa      420

acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac taactccatg      480

gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtgacagt gacctggaac      540

tctggatccc tgtccagcgg tgtgcacacc ttcccagctg tcctgcagtc tgacctctac      600

actctgagca gctcagtgac tgtcccctcc agcacctggc ccagcgagac cgtcacctgc      660

aacgttgccc acccggccag cagcaccaag gtggacaaga aaattgtgcc cagggattgt      720

ggttgtaagc cttgcatatg tacagtccca gaagtatcat ctgtcttcat cttcccccca      780

aagcccaagg atgtgctcac cattactctg actcctaagg tcacgtgtgt tgtggtagac      840

atcagcaagg atgatcccga ggtccagttc agctggtttg tagatgatgt ggaggtgcac      900

acagctcaga cgcaaccccg ggaggagcag ttcaacagca ctttccgctc agtcagtgaa      960

cttcccatca tgcaccagga ctggctcaat ggcaaggagt tcaaatgcag ggtcaacagt     1020

gcagctttcc ctgcccccat cgagaaaacc atctccaaaa ccaaaggcag accgaaggct     1080

ccacaggtgt acaccattcc acctcccaag gagcagatgg ccaaggataa agtcagtctg     1140

acctgcatga taacagactt cttccctgaa gacattactg tggagtggca gtggaatggg     1200

cagccagcgg agaactacaa gaacactcag cccatcatgg acacagatgg ctcttacttc     1260

gtctacagca agctcaatgt gcagaagagc aactgggagg caggaaatac tttcacctgc     1320

tctgtgttac atgagggcct gcacaaccac catactgaga agagcctctc ccactctcct     1380

ggtaaatga                                                             1389


<210>  10
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<400>  10
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcaaaaacca      180

gatggaactg ttaaactcct gatctactac acatcaacat tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      300

gaagatgttg ccacttactt ttgccaacag ggttatacac ttccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagacg tcaatgtcaa gtggaagatt gatggcagtg aacgacaaag tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccattgtcac gagcttcaac aggaatgagt gttag                      705


<210>  11
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Pro Leu Val Lys Thr Glu Pro Gln Arg Pro Val 
            180                 185                 190         


Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp Gln Glu Pro Ser 
        195                 200                 205             


Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser Arg Pro Arg Arg 
    210                 215                 220                 


Leu Ser Thr Ala Asp Pro Ala Asp Ala Ser Thr Ile Tyr Ala Val Val 
225                 230                 235                 240 


Val 
    


