                         SEQUENCE LISTING

<110>  Nogra Pharma Limited
 
<120>  FRAGILE X MENTAL RETARDATION PROTEIN INTERFERING OLIGONUCLEOTIDES
        AND METHODS OF USING SAME

<130>  GIU-059WO

<150>   62/810,697
<151>  2019-02-26

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  1
ccaccaccag ctcctcca                                                     18


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  2
cttccaccac cagctcct                                                     18


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  3
tccaccacca gctcctcc                                                     18


<210>  4
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  4
cttccaccac cagctcc                                                      17


<210>  5
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  5
tcacccttta tcatcctc                                                     18


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  6
tccaccacca gctcctccat                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  7
acttccacca ccagctcctc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  8
ttccaccacc agctcctcca                                                   20


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  9
acttccacca ccagctcct                                                    19


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  10
ctcacccttt atcatcctca                                                   20


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Synthetic primer (human
       FMRP)

<400>  11
gttgagcggc cgagtttgtc ag                                                22


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Synthetic primer (human
       FMRP)

<400>  12
cccactggga gaggattatt tggg                                              24


<210>  13
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Synthetic primer (human
       and mouse b-actin)

<400>  13
aagatgaccc agatcatgtt tgagacc                                           27


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Synthetic primer (human
       and mouse b-actin)

<400>  14
agccagtcca gacgcaggat                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  15
atggaggagc tggtggtgga                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Antisense 
       Oligonucleotide

<400>  16
gcatctccac tctgctggtt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Note= Description of Artificial Sequence: Sense Oligonucleotide

<400>  17
aaccagcaga gtggagatgc                                                   20


<210>  18
<211>  4140
<212>  DNA
<213>  Homo sapiens

<400>  18
acttccggtg gagggccgcc tctgagcggg cggcgggccg acggcgagcg cgggcggcgg       60

cggtgacgga ggcgccgctg ccagggggcg tgcggcagcg cggcggcggc ggcggcggcg      120

gcggcggcgg aggcggcggc ggcggcggcg gcggcggcgg ctgggcctcg agcgcccgca      180

gcccacctct cgggggcggg ctcccggcgc tagcagggct gaagagaaga tggaggagct      240

ggtggtggaa gtgcggggct ccaatggcgc tttctacaag gcatttgtaa aggatgttca      300

tgaagattca ataacagttg catttgaaaa caactggcag cctgataggc agattccatt      360

tcatgatgtc agattcccac ctcctgtagg ttataataaa gatataaatg aaagtgatga      420

agttgaggtg tattccagag caaatgaaaa agagccttgc tgttggtggt tagctaaagt      480

gaggatgata aagggtgagt tttatgtgat agaatatgca gcatgtgatg caacttacaa      540

tgaaattgtc acaattgaac gtctaagatc tgttaatccc aacaaacctg ccacaaaaga      600

tactttccat aagatcaagc tggatgtgcc agaagactta cggcaaatgt gtgccaaaga      660

ggcggcacat aaggatttta aaaaggcagt tggtgccttt tctgtaactt atgatccaga      720

aaattatcag cttgtcattt tgtccatcaa tgaagtcacc tcaaagcgag cacatatgct      780

gattgacatg cactttcgga gtctgcgcac taagttgtct ctgataatga gaaatgaaga      840

agctagtaag cagctggaga gttcaaggca gcttgcctcg agatttcatg aacagtttat      900

cgtaagagaa gatctgatgg gtctagctat tggtactcat ggtgctaata ttcagcaagc      960

tagaaaagta cctggggtca ctgctattga tctagatgaa gatacctgca catttcatat     1020

ttatggagag gatcaggatg cagtgaaaaa agctagaagc tttctcgaat ttgctgaaga     1080

tgtaatacaa gttccaagga acttagtagg caaagtaata ggaaaaaatg gaaagctgat     1140

tcaggagatt gtggacaagt caggagttgt gagggtgagg attgaggctg aaaatgagaa     1200

aaatgttcca caagaagagg aaattatgcc accaaattcc cttccttcca ataattcaag     1260

ggttggacct aatgccccag aagaaaaaaa acatttagat ataaaggaaa acagcaccca     1320

tttttctcaa cctaacagta caaaagtcca gagggtgtta gtggcttcat cagttgtagc     1380

aggggaatcc cagaaacctg aactcaaggc ttggcagggt atggtaccat ttgtttttgt     1440

gggaacaaag gacagcatcg ctaatgccac tgttcttttg gattatcacc tgaactattt     1500

aaagctccaa cagaggaaga gagggagagc ttcctgcgca gaggagacgg acggcggcgt     1560

ggagggggag gaagaggaca aggaggaaga ggacgtggag gaggcttcaa aggaaacgac     1620

gatcactccc gaacagataa tcgtccacgt aatccaagag aggctaaagg aagaacaaca     1680

gatggatccc ttcagatcag agttgactgc aataatgaaa ggagtgtcca cactaaaaca     1740

ttacagaata cctccagtga aggtagtcgg ctgcgcacgg gtaaagatcg taaccagaag     1800

aaagagaagc cagacagcgt ggatggtcag caaccactcg tgaatggagt accctaaact     1860

gcataattct gaagttatat ttcctatacc atttccgtaa ttcttattcc atattagaaa     1920

actttgttag gccaaagaca aatagtaggc aagatggcac agggcatgaa atgaacacaa     1980

attatgctaa gaatttttta ttttttggta ttggccataa gcaacaattt tcagatttgc     2040

acaaaaagat accttaaaat ttgaaacatt gcttttaaaa ctacttagca cttcagggca     2100

gattttagtt ttattttcta aagtactgag cagtgatatt ctttgttaat ttggaccatt     2160

ttcctgcatt gggtgatcat tcaccagtac attctcagtt tttcttaata tatagcattt     2220

atggtaatca tattagactt ctgttttcaa tctcgtatag aagtcttcat gaaatgctat     2280

gtcatttcat gtcctgtgtc agtttatgtt ttggtccact tttccagtat tttagtggac     2340

cctgaaatgt gtgtgatgtg acatttgtca ttttcattag caaaaaaagt tgtatgatct     2400

gtgccttttt tatatcttgg caggtaggaa tattatattt ggatgcagag ttcagggaag     2460

ataagttgga aacactaaat gttaaagatg tagcaaaccc tgtcaaacat tagtacttta     2520

tagaagaatg catgctttcc atattttttt ccttacataa acatcaggtt aggcagtata     2580

aagaatagga cttgtttttg tttttgtttt gttgcactga agtttgataa atagtgttat     2640

tgagagagat gtgtaatttt tctgtataga caggagaaga aagaactatc ttcatctgag     2700

agaggctaaa atgttttcag ctaggaacaa atcttcctgg tcgaaagtta gtaggatatg     2760

cctgctcttt ggcctgatga ccaattttaa cttagagctt ttttttttta attttgtctg     2820

ccccaagttt tgtgaaattt ttcatatttt aatttcaagc ttattttgga gagataggaa     2880

ggtcatttcc atgtatgcat aataatcctg caaagtacag gtactttgtc taagaaacat     2940

tggaagcagg ttaaatgttt tgtaaacttt gaaatatatg gtctaatgtt taagcagaat     3000

tggaaaagac taagatcggt taacaaataa caactttttt ttcttttttt cttttgtttt     3060

ttgaagtgtt ggggtttggt tttgtttttt gagtcttttt tttttaagtg aaatttattg     3120

aggaaaaata tgtgaaggac cttcactcta agatgttata tttttcttaa aaagtaactc     3180

ctagtagggg taccactgaa tctgtacaga gccgtaaaaa ctgaagttct gcctctgatg     3240

tattttgtga gtttgtttct ttgaattttc attttacagt tacttttcct tgcatacaaa     3300

caagcatata aaatggcaac aaactgcaca tgatttcaca aatattaaaa agtcttttaa     3360

aaagtattgc caaacattaa tgttgatttc tagttattta ttctgggaat gtatagtatt     3420

tgaaaacaga aattggtacc ttgcacacat catctgtaag ctgtttggtt ttaaaatact     3480

gtagataatt aaccaaggta gaatgacctt gtaatgtaac tgctcttggg caatattctc     3540

tgtacatatt agcgacaaca gattggattt tatgttgaca tttgtttggt tatagtgcaa     3600

tatattttgt atgcaagcag tttcaataaa gtttgatctt cctctgctaa attgatgttg     3660

atgcaatcct tacaaatgat tgcttttaaa attttaagct aggaaaagaa atctatagaa     3720

agtgttctgt tacaaaatgt aactgttacc attggaaatt tcacgtcata ggaagttagc     3780

ctttatctac caactttcaa gaacttgttt aataaagcga aaaactcaac caaatggtac     3840

aaaaccacag tgtaccatta aaatatgcac taagtctctt ttttacaaag gctgtattca     3900

gcaaggcgct aacttgctta aatgtgaatt actaacttct aaaactgtac tttgattcac     3960

atgttttcaa atggagttgg agttcattca tattacaata tttgtgtgct aaacgtgtat     4020

gtttttcagt tcaaagtcat gatgttttta aaatcttatt aaagtttcaa aaatctgaag     4080

attgtttatc tagatgtaaa tttttattaa aaagttgcac ttatgaaaaa gcaaaaaatt     4140


<210>  19
<211>  4348
<212>  DNA
<213>  Homo sapiens

<400>  19
acttccggtg gagggccgcc tctgagcggg cggcgggccg acggcgagcg cgggcggcgg       60

cggtgacgga ggcgccgctg ccagggggcg tgcggcagcg cggcggcggc ggcggcggcg      120

gcggcggcgg aggcggcggc ggcggcggcg gcggcggcgg ctgggcctcg agcgcccgca      180

gcccacctct cgggggcggg ctcccggcgc tagcagggct gaagagaaga tggaggagct      240

ggtggtggaa gtgcggggct ccaatggcgc tttctacaag gcatttgtaa aggatgttca      300

tgaagattca ataacagttg catttgaaaa caactggcag cctgataggc agattccatt      360

tcatgatgtc agattcccac ctcctgtagg ttataataaa gatataaatg aaagtgatga      420

agttgaggtg tattccagag caaatgaaaa agagccttgc tgttggtggt tagctaaagt      480

gaggatgata aagggtgagt tttatgtgat agaatatgca gcatgtgatg caacttacaa      540

tgaaattgtc acaattgaac gtctaagatc tgttaatccc aacaaacctg ccacaaaaga      600

tactttccat aagatcaagc tggatgtgcc agaagactta cggcaaatgt gtgccaaaga      660

ggcggcacat aaggatttta aaaaggcagt tggtgccttt tctgtaactt atgatccaga      720

aaattatcag cttgtcattt tgtccatcaa tgaagtcacc tcaaagcgag cacatatgct      780

gattgacatg cactttcgga gtctgcgcac taagttgtct ctgataatga gaaatgaaga      840

agctagtaag cagctggaga gttcaaggca gcttgcctcg agatttcatg aacagtttat      900

cgtaagagaa gatctgatgg gtctagctat tggtactcat ggtgctaata ttcagcaagc      960

tagaaaagta cctggggtca ctgctattga tctagatgaa gatacctgca catttcatat     1020

ttatggagag gatcaggatg cagtgaaaaa agctagaagc tttctcgaat ttgctgaaga     1080

tgtaatacaa gttccaagga acttagtagg caaagtaata ggaaaaaatg gaaagctgat     1140

tcaggagatt gtggacaagt caggagttgt gagggtgagg attgaggctg aaaatgagaa     1200

aaatgttcca caagaagagg aaattatgcc accaaattcc cttccttcca ataattcaag     1260

ggttggacct aatgccccag aagaaaaaaa acatttagat ataaaggaaa acagcaccca     1320

tttttctcaa cctaacagta caaaagtcca gaggggtatg gtaccatttg tttttgtggg     1380

aacaaaggac agcatcgcta atgccactgt tcttttggat tatcacctga actatttaaa     1440

ggaagtagac cagttgcgtt tggagagatt acaaattgat gagcagttgc gacagattgg     1500

agctagttct agaccaccac caaatcgtac agataaggaa aaaagctatg tgactgatga     1560

tggtcaagga atgggtcgag gtagtagacc ttacagaaat agggggcacg gcagacgcgg     1620

tcctggatat acttcaggaa ctaattctga agcatcaaat gcttctgaaa cagaatctga     1680

ccacagagac gaactcagtg attggtcatt agctccaaca gaggaagaga gggagagctt     1740

cctgcgcaga ggagacggac ggcggcgtgg agggggagga agaggacaag gaggaagagg     1800

acgtggagga ggcttcaaag gaaacgacga tcactcccga acagataatc gtccacgtaa     1860

tccaagagag gctaaaggaa gaacaacaga tggatccctt cagatcagag ttgactgcaa     1920

taatgaaagg agtgtccaca ctaaaacatt acagaatacc tccagtgaag gtagtcggct     1980

gcgcacgggt aaagatcgta accagaagaa agagaagcca gacagcgtgg atggtcagca     2040

accactcgtg aatggagtac cctaaactgc ataattctga agttatattt cctataccat     2100

ttccgtaatt cttattccat attagaaaac tttgttaggc caaagacaaa tagtaggcaa     2160

gatggcacag ggcatgaaat gaacacaaat tatgctaaga attttttatt ttttggtatt     2220

ggccataagc aacaattttc agatttgcac aaaaagatac cttaaaattt gaaacattgc     2280

ttttaaaact acttagcact tcagggcaga ttttagtttt attttctaaa gtactgagca     2340

gtgatattct ttgttaattt ggaccatttt cctgcattgg gtgatcattc accagtacat     2400

tctcagtttt tcttaatata tagcatttat ggtaatcata ttagacttct gttttcaatc     2460

tcgtatagaa gtcttcatga aatgctatgt catttcatgt cctgtgtcag tttatgtttt     2520

ggtccacttt tccagtattt tagtggaccc tgaaatgtgt gtgatgtgac atttgtcatt     2580

ttcattagca aaaaaagttg tatgatctgt gcctttttta tatcttggca ggtaggaata     2640

ttatatttgg atgcagagtt cagggaagat aagttggaaa cactaaatgt taaagatgta     2700

gcaaaccctg tcaaacatta gtactttata gaagaatgca tgctttccat atttttttcc     2760

ttacataaac atcaggttag gcagtataaa gaataggact tgtttttgtt tttgttttgt     2820

tgcactgaag tttgataaat agtgttattg agagagatgt gtaatttttc tgtatagaca     2880

ggagaagaaa gaactatctt catctgagag aggctaaaat gttttcagct aggaacaaat     2940

cttcctggtc gaaagttagt aggatatgcc tgctctttgg cctgatgacc aattttaact     3000

tagagctttt tttttttaat tttgtctgcc ccaagttttg tgaaattttt catattttaa     3060

tttcaagctt attttggaga gataggaagg tcatttccat gtatgcataa taatcctgca     3120

aagtacaggt actttgtcta agaaacattg gaagcaggtt aaatgttttg taaactttga     3180

aatatatggt ctaatgttta agcagaattg gaaaagacta agatcggtta acaaataaca     3240

actttttttt ctttttttct tttgtttttt gaagtgttgg ggtttggttt tgttttttga     3300

gtcttttttt tttaagtgaa atttattgag gaaaaatatg tgaaggacct tcactctaag     3360

atgttatatt tttcttaaaa agtaactcct agtaggggta ccactgaatc tgtacagagc     3420

cgtaaaaact gaagttctgc ctctgatgta ttttgtgagt ttgtttcttt gaattttcat     3480

tttacagtta cttttccttg catacaaaca agcatataaa atggcaacaa actgcacatg     3540

atttcacaaa tattaaaaag tcttttaaaa agtattgcca aacattaatg ttgatttcta     3600

gttatttatt ctgggaatgt atagtatttg aaaacagaaa ttggtacctt gcacacatca     3660

tctgtaagct gtttggtttt aaaatactgt agataattaa ccaaggtaga atgaccttgt     3720

aatgtaactg ctcttgggca atattctctg tacatattag cgacaacaga ttggatttta     3780

tgttgacatt tgtttggtta tagtgcaata tattttgtat gcaagcagtt tcaataaagt     3840

ttgatcttcc tctgctaaat tgatgttgat gcaatcctta caaatgattg cttttaaaat     3900

tttaagctag gaaaagaaat ctatagaaag tgttctgtta caaaatgtaa ctgttaccat     3960

tggaaatttc acgtcatagg aagttagcct ttatctacca actttcaaga acttgtttaa     4020

taaagcgaaa aactcaacca aatggtacaa aaccacagtg taccattaaa atatgcacta     4080

agtctctttt ttacaaaggc tgtattcagc aaggcgctaa cttgcttaaa tgtgaattac     4140

taacttctaa aactgtactt tgattcacat gttttcaaat ggagttggag ttcattcata     4200

ttacaatatt tgtgtgctaa acgtgtatgt ttttcagttc aaagtcatga tgtttttaaa     4260

atcttattaa agtttcaaaa atctgaagat tgtttatcta gatgtaaatt tttattaaaa     4320

agttgcactt atgaaaaagc aaaaaatt                                        4348


<210>  20
<211>  4107
<212>  DNA
<213>  Homo sapiens

<400>  20
ctcagtcagg cgctcagctc cgtttcggtt tcacttccgg tggagggccg cctctgagcg       60

ggcggcgggc cgacggcgag cgcgggcggc ggcggtgacg gaggcgccgc tgccaggggg      120

cgtgcggcag cgcggcggcg gcggcggcgg cggcggcggc ggaggcggcg gcggcggcgg      180

cggcggcggc ggctgggcct cgagcgcccg cagcccacct ctcgggggcg ggctcccggc      240

gctagcaggg ctgaagagaa gatggaggag ctggtggtgg aagtgcgggg ctccaatggc      300

gctttctaca aggcatttgt aaaggatgtt catgaagatt caataacagt tgcatttgaa      360

aacaactggc agcctgatag gcagattcca tttcatgatg tcagattccc acctcctgta      420

ggttataata aagatataaa tgaaagtgat gaagttgagg tgtattccag agcaaatgaa      480

aaagagcctt gctgttggtg gttagctaaa gtgaggatga taaagggtga gttttatgtg      540

atagaatatg cagcatgtga tgcaacttac aatgaaattg tcacaattga acgtctaaga      600

tctgttaatc ccaacaaacc tgccacaaaa gatactttcc ataagatcaa gctggatgtg      660

ccagaagact tacggcaaat gtgtgccaaa gaggcggcac ataaggattt taaaaaggca      720

gttggtgcct tttctgtaac ttatgatcca gaaaattatc agcttgtcat tttgtccatc      780

aatgaagtca cctcaaagcg agcacatatg ctgattgaca tgcactttcg gagtctgcgc      840

actaagttgt ctctgataat gagaaatgaa gaagctagta agcagctgga gagttcaagg      900

cagcttgcct cgagatttca tgaacagttt atcgtaagag aagatctgat gggtctagct      960

attggtactc atggtgctaa tattcagcaa gctagaaaag tacctggggt cactgctatt     1020

gatctagatg aagatacctg cacatttcat atttatggag aggatcagga tgcagtgaaa     1080

aaagctagaa gctttctcga atttgctgaa gatgtaatac aagttccaag gaacttagta     1140

ggcaaagtaa taggaaaaaa tggaaagctg attcaggaga ttgtggacaa gtcaggagtt     1200

gtgagggtga ggattgaggc tgaaaatgag aaaaatgttc cacaagaaga ggaaattatg     1260

ccaccaaatt cccttccttc caataattca agggttggac ctaatgcccc agaagaaaaa     1320

aaacatttag atataaagga aaacagcacc catttttctc aacctaacag tacaaaagtc     1380

cagaggggta tggtaccatt tgtttttgtg ggaacaaagg acagcatcgc taatgccact     1440

gttcttttgg attatcacct gaactattta aagctccaac agaggaagag agggagagct     1500

tcctgcgcag aggagacgga cggcggcgtg gagggggagg aagaggacaa ggaggaagag     1560

gacgtggagg aggcttcaaa ggaaacgacg atcactcccg aacagataat cgtccacgta     1620

atccaagaga ggctaaagga agaacaacag atggatccct tcagatcaga gttgactgca     1680

ataatgaaag gagtgtccac actaaaacat tacagaatac ctccagtgaa ggtagtcggc     1740

tgcgcacggg taaagatcgt aaccagaaga aagagaagcc agacagcgtg gatggtcagc     1800

aaccactcgt gaatggagta ccctaaactg cataattctg aagttatatt tcctatacca     1860

tttccgtaat tcttattcca tattagaaaa ctttgttagg ccaaagacaa atagtaggca     1920

agatggcaca gggcatgaaa tgaacacaaa ttatgctaag aattttttat tttttggtat     1980

tggccataag caacaatttt cagatttgca caaaaagata ccttaaaatt tgaaacattg     2040

cttttaaaac tacttagcac ttcagggcag attttagttt tattttctaa agtactgagc     2100

agtgatattc tttgttaatt tggaccattt tcctgcattg ggtgatcatt caccagtaca     2160

ttctcagttt ttcttaatat atagcattta tggtaatcat attagacttc tgttttcaat     2220

ctcgtataga agtcttcatg aaatgctatg tcatttcatg tcctgtgtca gtttatgttt     2280

tggtccactt ttccagtatt ttagtggacc ctgaaatgtg tgtgatgtga catttgtcat     2340

tttcattagc aaaaaaagtt gtatgatctg tgcctttttt atatcttggc aggtaggaat     2400

attatatttg gatgcagagt tcagggaaga taagttggaa acactaaatg ttaaagatgt     2460

agcaaaccct gtcaaacatt agtactttat agaagaatgc atgctttcca tatttttttc     2520

cttacataaa catcaggtta ggcagtataa agaataggac ttgtttttgt ttttgttttg     2580

ttgcactgaa gtttgataaa tagtgttatt gagagagatg tgtaattttt ctgtatagac     2640

aggagaagaa agaactatct tcatctgaga gaggctaaaa tgttttcagc taggaacaaa     2700

tcttcctggt cgaaagttag taggatatgc ctgctctttg gcctgatgac caattttaac     2760

ttagagcttt ttttttttaa ttttgtctgc cccaagtttt gtgaaatttt tcatatttta     2820

atttcaagct tattttggag agataggaag gtcatttcca tgtatgcata ataatcctgc     2880

aaagtacagg tactttgtct aagaaacatt ggaagcaggt taaatgtttt gtaaactttg     2940

aaatatatgg tctaatgttt aagcagaatt ggaaaagact aagatcggtt aacaaataac     3000

aacttttttt tctttttttc ttttgttttt tgaagtgttg gggtttggtt ttgttttttg     3060

agtctttttt ttttaagtga aatttattga ggaaaaatat gtgaaggacc ttcactctaa     3120

gatgttatat ttttcttaaa aagtaactcc tagtaggggt accactgaat ctgtacagag     3180

ccgtaaaaac tgaagttctg cctctgatgt attttgtgag tttgtttctt tgaattttca     3240

ttttacagtt acttttcctt gcatacaaac aagcatataa aatggcaaca aactgcacat     3300

gatttcacaa atattaaaaa gtcttttaaa aagtattgcc aaacattaat gttgatttct     3360

agttatttat tctgggaatg tatagtattt gaaaacagaa attggtacct tgcacacatc     3420

atctgtaagc tgtttggttt taaaatactg tagataatta accaaggtag aatgaccttg     3480

taatgtaact gctcttgggc aatattctct gtacatatta gcgacaacag attggatttt     3540

atgttgacat ttgtttggtt atagtgcaat atattttgta tgcaagcagt ttcaataaag     3600

tttgatcttc ctctgctaaa ttgatgttga tgcaatcctt acaaatgatt gcttttaaaa     3660

ttttaagcta ggaaaagaaa tctatagaaa gtgttctgtt acaaaatgta actgttacca     3720

ttggaaattt cacgtcatag gaagttagcc tttatctacc aactttcaag aacttgttta     3780

ataaagcgaa aaactcaacc aaatggtaca aaaccacagt gtaccattaa aatatgcact     3840

aagtctcttt tttacaaagg ctgtattcag caaggcgcta acttgcttaa atgtgaatta     3900

ctaacttcta aaactgtact ttgattcaca tgttttcaaa tggagttgga gttcattcat     3960

attacaatat ttgtgtgcta aacgtgtatg tttttcagtt caaagtcatg atgtttttaa     4020

aatcttatta aagtttcaaa aatctgaaga ttgtttatct agatgtaaat ttttattaaa     4080

aagttgcact tatgaaaaag caaaaaa                                         4107


<210>  21
<211>  4303
<212>  DNA
<213>  Homo sapiens

<400>  21
ctcagtcagg cgctcagctc cgtttcggtt tcacttccgg tggagggccg cctctgagcg       60

ggcggcgggc cgacggcgag cgcgggcggc ggcggtgacg gaggcgccgc tgccaggggg      120

cgtgcggcag cgcggcggcg gcggcggcgg cggcggcggc ggaggcggcg gcggcggcgg      180

cggcggcggc ggctgggcct cgagcgcccg cagcccacct ctcgggggcg ggctcccggc      240

gctagcaggg ctgaagagaa gatggaggag ctggtggtgg aagtgcgggg ctccaatggc      300

gctttctaca aggcatttgt aaaggatgtt catgaagatt caataacagt tgcatttgaa      360

aacaactggc agcctgatag gcagattcca tttcatgatg tcagattccc acctcctgta      420

ggttataata aagatataaa tgaaagtgat gaagttgagg tgtattccag agcaaatgaa      480

aaagagcctt gctgttggtg gttagctaaa gtgaggatga taaagggtga gttttatgtg      540

atagaatatg cagcatgtga tgcaacttac aatgaaattg tcacaattga acgtctaaga      600

tctgttaatc ccaacaaacc tgccacaaaa gatactttcc ataagatcaa gctggatgtg      660

ccagaagact tacggcaaat gtgtgccaaa gaggcggcac ataaggattt taaaaaggca      720

gttggtgcct tttctgtaac ttatgatcca gaaaattatc agcttgtcat tttgtccatc      780

aatgaagtca cctcaaagcg agcacatatg ctgattgaca tgcactttcg gagtctgcgc      840

actaagttgt ctctgataat gagaaatgaa gaagctagta agcagctgga gagttcaagg      900

cagcttgcct cgagatttca tgaacagttt atcgtaagag aagatctgat gggtctagct      960

attggtactc atggtgctaa tattcagcaa gctagaaaag tacctggggt cactgctatt     1020

gatctagatg aagatacctg cacatttcat atttatggag aggatcagga tgcagtgaaa     1080

aaagctagaa gctttctcga atttgctgaa gatgtaatac aagttccaag gaacttagta     1140

ggcaaagtaa taggaaaaaa tggaaagctg attcaggaga ttgtggacaa gtcaggagtt     1200

gtgagggtga ggattgaggc tgaaaatgag aaaaatgttc cacaagaaga ggaaattatg     1260

ccaccaaatt cccttccttc caataattca agggttggac ctaatgcccc agaagaaaaa     1320

aaacatttag atataaagga aaacagcacc catttttctc aacctaacag tacaaaagtc     1380

cagaggggta tggtaccatt tgtttttgtg ggaacaaagg acagcatcgc taatgccact     1440

gttcttttgg attatcacct gaactattta aaggaagtag accagttgcg tttggagaga     1500

ttacaaattg atgagcagtt gcgacagatt ggagctagtt ctagaccacc accaaatcgt     1560

acagataagg aaaaaagcta tgtgactgat gatggtcaag gaatgggtcg aggtagtaga     1620

ccttacagaa atagggggca cggcagacgc ggtcctggat atacttcagc tccaacagag     1680

gaagagaggg agagcttcct gcgcagagga gacggacggc ggcgtggagg gggaggaaga     1740

ggacaaggag gaagaggacg tggaggaggc ttcaaaggaa acgacgatca ctcccgaaca     1800

gataatcgtc cacgtaatcc aagagaggct aaaggaagaa caacagatgg atcccttcag     1860

atcagagttg actgcaataa tgaaaggagt gtccacacta aaacattaca gaatacctcc     1920

agtgaaggta gtcggctgcg cacgggtaaa gatcgtaacc agaagaaaga gaagccagac     1980

agcgtggatg gtcagcaacc actcgtgaat ggagtaccct aaactgcata attctgaagt     2040

tatatttcct ataccatttc cgtaattctt attccatatt agaaaacttt gttaggccaa     2100

agacaaatag taggcaagat ggcacagggc atgaaatgaa cacaaattat gctaagaatt     2160

ttttattttt tggtattggc cataagcaac aattttcaga tttgcacaaa aagatacctt     2220

aaaatttgaa acattgcttt taaaactact tagcacttca gggcagattt tagttttatt     2280

ttctaaagta ctgagcagtg atattctttg ttaatttgga ccattttcct gcattgggtg     2340

atcattcacc agtacattct cagtttttct taatatatag catttatggt aatcatatta     2400

gacttctgtt ttcaatctcg tatagaagtc ttcatgaaat gctatgtcat ttcatgtcct     2460

gtgtcagttt atgttttggt ccacttttcc agtattttag tggaccctga aatgtgtgtg     2520

atgtgacatt tgtcattttc attagcaaaa aaagttgtat gatctgtgcc ttttttatat     2580

cttggcaggt aggaatatta tatttggatg cagagttcag ggaagataag ttggaaacac     2640

taaatgttaa agatgtagca aaccctgtca aacattagta ctttatagaa gaatgcatgc     2700

tttccatatt tttttcctta cataaacatc aggttaggca gtataaagaa taggacttgt     2760

ttttgttttt gttttgttgc actgaagttt gataaatagt gttattgaga gagatgtgta     2820

atttttctgt atagacagga gaagaaagaa ctatcttcat ctgagagagg ctaaaatgtt     2880

ttcagctagg aacaaatctt cctggtcgaa agttagtagg atatgcctgc tctttggcct     2940

gatgaccaat tttaacttag agcttttttt ttttaatttt gtctgcccca agttttgtga     3000

aatttttcat attttaattt caagcttatt ttggagagat aggaaggtca tttccatgta     3060

tgcataataa tcctgcaaag tacaggtact ttgtctaaga aacattggaa gcaggttaaa     3120

tgttttgtaa actttgaaat atatggtcta atgtttaagc agaattggaa aagactaaga     3180

tcggttaaca aataacaact tttttttctt tttttctttt gttttttgaa gtgttggggt     3240

ttggttttgt tttttgagtc tttttttttt aagtgaaatt tattgaggaa aaatatgtga     3300

aggaccttca ctctaagatg ttatattttt cttaaaaagt aactcctagt aggggtacca     3360

ctgaatctgt acagagccgt aaaaactgaa gttctgcctc tgatgtattt tgtgagtttg     3420

tttctttgaa ttttcatttt acagttactt ttccttgcat acaaacaagc atataaaatg     3480

gcaacaaact gcacatgatt tcacaaatat taaaaagtct tttaaaaagt attgccaaac     3540

attaatgttg atttctagtt atttattctg ggaatgtata gtatttgaaa acagaaattg     3600

gtaccttgca cacatcatct gtaagctgtt tggttttaaa atactgtaga taattaacca     3660

aggtagaatg accttgtaat gtaactgctc ttgggcaata ttctctgtac atattagcga     3720

caacagattg gattttatgt tgacatttgt ttggttatag tgcaatatat tttgtatgca     3780

agcagtttca ataaagtttg atcttcctct gctaaattga tgttgatgca atccttacaa     3840

atgattgctt ttaaaatttt aagctaggaa aagaaatcta tagaaagtgt tctgttacaa     3900

aatgtaactg ttaccattgg aaatttcacg tcataggaag ttagccttta tctaccaact     3960

ttcaagaact tgtttaataa agcgaaaaac tcaaccaaat ggtacaaaac cacagtgtac     4020

cattaaaata tgcactaagt ctctttttta caaaggctgt attcagcaag gcgctaactt     4080

gcttaaatgt gaattactaa cttctaaaac tgtactttga ttcacatgtt ttcaaatgga     4140

gttggagttc attcatatta caatatttgt gtgctaaacg tgtatgtttt tcagttcaaa     4200

gtcatgatgt ttttaaaatc ttattaaagt ttcaaaaatc tgaagattgt ttatctagat     4260

gtaaattttt attaaaaagt tgcacttatg aaaaagcaaa aaa                       4303


<210>  22
<211>  4441
<212>  DNA
<213>  Homo sapiens

<400>  22
ctcagtcagg cgctcagctc cgtttcggtt tcacttccgg tggagggccg cctctgagcg       60

ggcggcgggc cgacggcgag cgcgggcggc ggcggtgacg gaggcgccgc tgccaggggg      120

cgtgcggcag cgcggcggcg gcggcggcgg cggcggcggc ggaggcggcg gcggcggcgg      180

cggcggcggc ggctgggcct cgagcgcccg cagcccacct ctcgggggcg ggctcccggc      240

gctagcaggg ctgaagagaa gatggaggag ctggtggtgg aagtgcgggg ctccaatggc      300

gctttctaca aggcatttgt aaaggatgtt catgaagatt caataacagt tgcatttgaa      360

aacaactggc agcctgatag gcagattcca tttcatgatg tcagattccc acctcctgta      420

ggttataata aagatataaa tgaaagtgat gaagttgagg tgtattccag agcaaatgaa      480

aaagagcctt gctgttggtg gttagctaaa gtgaggatga taaagggtga gttttatgtg      540

atagaatatg cagcatgtga tgcaacttac aatgaaattg tcacaattga acgtctaaga      600

tctgttaatc ccaacaaacc tgccacaaaa gatactttcc ataagatcaa gctggatgtg      660

ccagaagact tacggcaaat gtgtgccaaa gaggcggcac ataaggattt taaaaaggca      720

gttggtgcct tttctgtaac ttatgatcca gaaaattatc agcttgtcat tttgtccatc      780

aatgaagtca cctcaaagcg agcacatatg ctgattgaca tgcactttcg gagtctgcgc      840

actaagttgt ctctgataat gagaaatgaa gaagctagta agcagctgga gagttcaagg      900

cagcttgcct cgagatttca tgaacagttt atcgtaagag aagatctgat gggtctagct      960

attggtactc atggtgctaa tattcagcaa gctagaaaag tacctggggt cactgctatt     1020

gatctagatg aagatacctg cacatttcat atttatggag aggatcagga tgcagtgaaa     1080

aaagctagaa gctttctcga atttgctgaa gatgtaatac aagttccaag gaacttagta     1140

ggcaaagtaa taggaaaaaa tggaaagctg attcaggaga ttgtggacaa gtcaggagtt     1200

gtgagggtga ggattgaggc tgaaaatgag aaaaatgttc cacaagaaga ggaaattatg     1260

ccaccaaatt cccttccttc caataattca agggttggac ctaatgcccc agaagaaaaa     1320

aaacatttag atataaagga aaacagcacc catttttctc aacctaacag tacaaaagtc     1380

cagagggtgt tagtggcttc atcagttgta gcaggggaat cccagaaacc tgaactcaag     1440

gcttggcagg gtatggtacc atttgttttt gtgggaacaa aggacagcat cgctaatgcc     1500

actgttcttt tggattatca cctgaactat ttaaaggaag tagaccagtt gcgtttggag     1560

agattacaaa ttgatgagca gttgcgacag attggagcta gttctagacc accaccaaat     1620

cgtacagata aggaaaaaag ctatgtgact gatgatggtc aaggaatggg tcgaggtagt     1680

agaccttaca gaaatagggg gcacggcaga cgcggtcctg gatatacttc aggaactaat     1740

tctgaagcat caaatgcttc tgaaacagaa tctgaccaca gagacgaact cagtgattgg     1800

tcattagctc caacagagga agagagggag agcttcctgc gcagaggaga cggacggcgg     1860

cgtggagggg gaggaagagg acaaggagga agaggacgtg gaggaggctt caaaggaaac     1920

gacgatcact cccgaacaga taatcgtcca cgtaatccaa gagaggctaa aggaagaaca     1980

acagatggat cccttcagat cagagttgac tgcaataatg aaaggagtgt ccacactaaa     2040

acattacaga atacctccag tgaaggtagt cggctgcgca cgggtaaaga tcgtaaccag     2100

aagaaagaga agccagacag cgtggatggt cagcaaccac tcgtgaatgg agtaccctaa     2160

actgcataat tctgaagtta tatttcctat accatttccg taattcttat tccatattag     2220

aaaactttgt taggccaaag acaaatagta ggcaagatgg cacagggcat gaaatgaaca     2280

caaattatgc taagaatttt ttattttttg gtattggcca taagcaacaa ttttcagatt     2340

tgcacaaaaa gataccttaa aatttgaaac attgctttta aaactactta gcacttcagg     2400

gcagatttta gttttatttt ctaaagtact gagcagtgat attctttgtt aatttggacc     2460

attttcctgc attgggtgat cattcaccag tacattctca gtttttctta atatatagca     2520

tttatggtaa tcatattaga cttctgtttt caatctcgta tagaagtctt catgaaatgc     2580

tatgtcattt catgtcctgt gtcagtttat gttttggtcc acttttccag tattttagtg     2640

gaccctgaaa tgtgtgtgat gtgacatttg tcattttcat tagcaaaaaa agttgtatga     2700

tctgtgcctt ttttatatct tggcaggtag gaatattata tttggatgca gagttcaggg     2760

aagataagtt ggaaacacta aatgttaaag atgtagcaaa ccctgtcaaa cattagtact     2820

ttatagaaga atgcatgctt tccatatttt tttccttaca taaacatcag gttaggcagt     2880

ataaagaata ggacttgttt ttgtttttgt tttgttgcac tgaagtttga taaatagtgt     2940

tattgagaga gatgtgtaat ttttctgtat agacaggaga agaaagaact atcttcatct     3000

gagagaggct aaaatgtttt cagctaggaa caaatcttcc tggtcgaaag ttagtaggat     3060

atgcctgctc tttggcctga tgaccaattt taacttagag cttttttttt ttaattttgt     3120

ctgccccaag ttttgtgaaa tttttcatat tttaatttca agcttatttt ggagagatag     3180

gaaggtcatt tccatgtatg cataataatc ctgcaaagta caggtacttt gtctaagaaa     3240

cattggaagc aggttaaatg ttttgtaaac tttgaaatat atggtctaat gtttaagcag     3300

aattggaaaa gactaagatc ggttaacaaa taacaacttt tttttctttt tttcttttgt     3360

tttttgaagt gttggggttt ggttttgttt tttgagtctt ttttttttaa gtgaaattta     3420

ttgaggaaaa atatgtgaag gaccttcact ctaagatgtt atatttttct taaaaagtaa     3480

ctcctagtag gggtaccact gaatctgtac agagccgtaa aaactgaagt tctgcctctg     3540

atgtattttg tgagtttgtt tctttgaatt ttcattttac agttactttt ccttgcatac     3600

aaacaagcat ataaaatggc aacaaactgc acatgatttc acaaatatta aaaagtcttt     3660

taaaaagtat tgccaaacat taatgttgat ttctagttat ttattctggg aatgtatagt     3720

atttgaaaac agaaattggt accttgcaca catcatctgt aagctgtttg gttttaaaat     3780

actgtagata attaaccaag gtagaatgac cttgtaatgt aactgctctt gggcaatatt     3840

ctctgtacat attagcgaca acagattgga ttttatgttg acatttgttt ggttatagtg     3900

caatatattt tgtatgcaag cagtttcaat aaagtttgat cttcctctgc taaattgatg     3960

ttgatgcaat ccttacaaat gattgctttt aaaattttaa gctaggaaaa gaaatctata     4020

gaaagtgttc tgttacaaaa tgtaactgtt accattggaa atttcacgtc ataggaagtt     4080

agcctttatc taccaacttt caagaacttg tttaataaag cgaaaaactc aaccaaatgg     4140

tacaaaacca cagtgtacca ttaaaatatg cactaagtct cttttttaca aaggctgtat     4200

tcagcaaggc gctaacttgc ttaaatgtga attactaact tctaaaactg tactttgatt     4260

cacatgtttt caaatggagt tggagttcat tcatattaca atatttgtgt gctaaacgtg     4320

tatgtttttc agttcaaagt catgatgttt ttaaaatctt attaaagttt caaaaatctg     4380

aagattgttt atctagatgt aaatttttat taaaaagttg cacttatgaa aaagcaaaaa     4440

a                                                                     4441


