                         б

<110>  ҩҵϺɷ޹˾
 
<120>  LAG-3Ŀ塢Ʊ;

<130>  SH363-20P450007

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  1
gaggtccagc tgcaacagtc tggacctgtg ctggtgaagc ctggggcttc agtaaagatg       60

tcctgtaagg cttctggata cacactcact gcctactata tgaactgggt gaagcaaagt      120

cgtggaaaga gccttgagtg gattggagtt attaatcctt acaacggtga ttctagctac      180

aaccagaagt tcaagggcaa ggccacattg actgttgaca agtcctccag cacagcctac      240

atggagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagggatgat      300

ggttactacc gatggtactt cgatgtctgg ggcacaggga ccacggtcac cgtctcctca      360


<210>  2
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Ala Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser Arg Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Asp Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Tyr Arg Trp Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  3
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggacattggt agtagattaa actggcttca gcagggacca      120

gatggaagta ttaaacgcct gatctacgcc acatccagtt tagaatctgg tgtccccaaa      180

aggttcagtg gcagtaggtc tgggtcagat tactttctca ccatcagcag ccttgagtct      240

gaagattttg tagactatta ctgtctacag tgtggtagtt ctcctccgac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  4
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Gly Pro Asp Gly Ser Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Glu Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Phe Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Cys Gly Ser Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  5
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt gacgattaca tggcttggtt tcgccagact      120

cctgagaaaa ggctggagtg ggtcgcatcc attagtcatg gtggtgatta catctactat      180

gcagacaatt tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatat atttctgttc aagagatcgg      300

cgatccattg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  6
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  6

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser His Gly Gly Asp Tyr Ile Tyr Tyr Ala Asp Asn Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ser Arg Asp Arg Arg Ser Ile Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  7
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  7
gatatccaga tgacacagat tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcacttgca gggcaagtca ggacattagc aattatttaa gctggtatca gcagaaacca      120

gatggaacta ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcga cctggagcaa      240

gaagatatcg ccacttactt ttgccaacag ggtaaaacgc ttccgtacac gttcggaggg      300

gggaccaagc tggaaagaaa a                                                321


<210>  8
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Ile Gln Met Thr Gln Ile Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asp Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Arg Lys 
            100                 105         


<210>  9
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  9

Ala Tyr Tyr Met Asn 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  10

Val Ile Asn Pro Tyr Asn Gly Asp Ser Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  11

Asp Asp Gly Tyr Tyr Arg Trp Tyr Phe Asp Val 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  12

Arg Ala Ser Gln Asp Ile Gly Ser Arg Leu Asn 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  13

Ala Thr Ser Ser Leu Glu Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  14

Leu Gln Cys Gly Ser Ser Pro Pro Thr 
1               5                   


<210>  15
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  15

Asp Asp Tyr Met Ala 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  16

Ser Ile Ser His Gly Gly Asp Tyr Ile Tyr Tyr Ala Asp Asn Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  17

Asp Arg Arg Ser Ile Asp Tyr 
1               5           


<210>  18
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  18

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ser 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  19

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  20

Gln Gln Gly Lys Thr Leu Pro Tyr Thr 
1               5                   


<210>  21
<211>  360
<212>  DNA
<213>  Synthetic

<400>  21
caagtgcagc tggtgcagtc cggcgccgaa gtgaagaagc ctggcgcctc cgtgaaggtg       60

agctgcaagg cttccggcta caccctgacc gcctactaca tgaactgggt gaggcaggcc      120

cctggccagt ccctggaatg gatcggcgtg atcaacccct acaacggcga ctcctcctat      180

aaccagaagt tcaagggccg ggccaccctg accgtggaca agtccaccag caccgcctac      240

atggagctgt cctccctgag gtccgaggac accgccgtct actactgcgc cagggacgac      300

ggctactaca ggtggtactt cgacgtgtgg ggccagggca ccctggtgac agtgtcctcc      360


<210>  22
<211>  120
<212>  PRT
<213>  Synthetic

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Ala Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Asp Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Tyr Arg Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  321
<212>  DNA
<213>  Synthetic

<400>  23
gacatccaga tgacccagtc cccttcctcc ctgtccgctt ccgtgggcga cagggtgacc       60

atcacctgta gggcctccca ggacatcggc tccaggctga actggctgca gcagaagccc      120

ggcaagtcca tcaagcggct gatctacgcc acctcctccc tggagtccgg cgtgccttcc      180

aggttctccg gctccaggtc cggctccgac tacaccctga ccatctcctc cctgcagccc      240

gaggacttcg ccacctacta ctgcctgcag tccggctcct cccctcctac cttcggccag      300

ggcaccaagg tggagatcaa g                                                321


<210>  24
<211>  107
<212>  PRT
<213>  Synthetic

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ser Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Gly Ser Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  25
<211>  348
<212>  DNA
<213>  Synthetic

<400>  25
gaagtgcagc tggtggagtc cggaggcgga ctggtgaagc ctggaggctc cctgaggctg       60

tcctgtgccg cttccggctt caccttctcc gacgactaca tggcctggtt caggcaggcc      120

cctggaaaga ggctggagtg ggtggcttcc atctcccacg gcggcgacta catctactac      180

gccgacaacc tgaagggcag gttcaccatc tccagggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgag ggccgaggac accgccgtgt acttctgctc cagggacagg      300

aggtccatcg actattgggg ccagggcacc ctggtgacag tgtcctcc                   348


<210>  26
<211>  116
<212>  PRT
<213>  Synthetic

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser His Gly Gly Asp Tyr Ile Tyr Tyr Ala Asp Asn Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ser Arg Asp Arg Arg Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  27
<211>  321
<212>  DNA
<213>  Synthetic

<400>  27
gacatccaga tgacccagtc cccttcctcc ctgtccgctt ccgtgggcga cagggtgacc       60

atcacctgca gggccagcca ggacatctcc aactacctgt cctggtacca gcagaagccc      120

ggcaagacca tcaagctgct gatctactac acctccaggc tgcacagcgg cgtgcctagc      180

aggttctccg gttctggctc cggcaccgac tacaccttca ccatcagctc cctgcagccc      240

gaggacatcg ccacctactt ctgccagcag ggcaagaccc tgccctacac cttcggccag      300

ggcaccaagg tggagatcaa g                                                321


<210>  28
<211>  107
<212>  PRT
<213>  Synthetic

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  29
<211>  981
<212>  DNA
<213>  Homo

<400>  29
gcaagtacca agggacctag tgttttccct cttgcacctt gctccaggtc aacatcagag       60

tccacagctg ctcttggatg tctcgttaag gactacttcc cagagccagt taccgtatcc      120

tggaactccg gagctttgac aagcggcgtt catacattcc cagctgtgtt gcagagttct      180

gggttgtaca gtttgagctc agtggtgacc gtgccttcat cttctttggg cactaagacc      240

tacacctgca acgtggatca caagccaagc aacaccaagg tggataagag ggtggagtcc      300

aagtacggcc caccatgtcc tccatgtcca gcccctgaat ttttgggcgg gccttctgtc      360

tttctgtttc ctcctaaacc taaagatacc ctgatgatca gccgcacacc cgaagtcact      420

tgtgtggtcg tggatgtgtc tcaggaagat cccgaagtgc agtttaactg gtatgtcgat      480

ggcgtggaag tgcataatgc caaaactaag ccccgcgaag aacagttcaa cagcacttat      540

cgggtcgtgt ctgtgctcac agtcctccat caggattggc tgaatgggaa agaatataag      600

tgcaaggtga gcaataaggg cctccccagc agcatcgaga agactattag caaagccaaa      660

gggcagccac gggaacccca ggtgtacact ctgcccccct ctcaggagga gatgactaaa      720

aatcaggtct ctctgacttg tctggtgaaa gggttttatc ccagcgacat tgccgtggag      780

tgggagtcta atggccagcc cgagaataat tataagacaa ctccccccgt cctggactct      840

gacggcagct ttttcctgta ttctcggctg acagtggaca aaagtcgctg gcaggagggc      900

aatgtcttta gttgcagtgt catgcatgag gccctgcaca atcactatac acagaaaagc      960

ctgtctctga gtctgggcaa a                                                981


<210>  30
<211>  327
<212>  PRT
<213>  Homo

<400>  30

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  31
<211>  1341
<212>  DNA
<213>  Synthetic

<400>  31
caagtgcagc tggtgcagtc cggcgccgaa gtgaagaagc ctggcgcctc cgtgaaggtg       60

agctgcaagg cttccggcta caccctgacc gcctactaca tgaactgggt gaggcaggcc      120

cctggccagt ccctggaatg gatcggcgtg atcaacccct acaacggcga ctcctcctat      180

aaccagaagt tcaagggccg ggccaccctg accgtggaca agtccaccag caccgcctac      240

atggagctgt cctccctgag gtccgaggac accgccgtct actactgcgc cagggacgac      300

ggctactaca ggtggtactt cgacgtgtgg ggccagggca ccctggtgac agtgtcctcc      360

gcaagtacca agggacctag tgttttccct cttgcacctt gctccaggtc aacatcagag      420

tccacagctg ctcttggatg tctcgttaag gactacttcc cagagccagt taccgtatcc      480

tggaactccg gagctttgac aagcggcgtt catacattcc cagctgtgtt gcagagttct      540

gggttgtaca gtttgagctc agtggtgacc gtgccttcat cttctttggg cactaagacc      600

tacacctgca acgtggatca caagccaagc aacaccaagg tggataagag ggtggagtcc      660

aagtacggcc caccatgtcc tccatgtcca gcccctgaat ttttgggcgg gccttctgtc      720

tttctgtttc ctcctaaacc taaagatacc ctgatgatca gccgcacacc cgaagtcact      780

tgtgtggtcg tggatgtgtc tcaggaagat cccgaagtgc agtttaactg gtatgtcgat      840

ggcgtggaag tgcataatgc caaaactaag ccccgcgaag aacagttcaa cagcacttat      900

cgggtcgtgt ctgtgctcac agtcctccat caggattggc tgaatgggaa agaatataag      960

tgcaaggtga gcaataaggg cctccccagc agcatcgaga agactattag caaagccaaa     1020

gggcagccac gggaacccca ggtgtacact ctgcccccct ctcaggagga gatgactaaa     1080

aatcaggtct ctctgacttg tctggtgaaa gggttttatc ccagcgacat tgccgtggag     1140

tgggagtcta atggccagcc cgagaataat tataagacaa ctccccccgt cctggactct     1200

gacggcagct ttttcctgta ttctcggctg acagtggaca aaagtcgctg gcaggagggc     1260

aatgtcttta gttgcagtgt catgcatgag gccctgcaca atcactatac acagaaaagc     1320

ctgtctctga gtctgggcaa a                                               1341


<210>  32
<211>  447
<212>  PRT
<213>  Synthetic

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Ala Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Asp Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Tyr Arg Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  33
<211>  321
<212>  DNA
<213>  Homo

<400>  33
cgcactgtgg ctgcccccag tgttttcata tttcccccca gtgatgagca actgaagtcc       60

ggcacagcct ctgttgtatg tctgctgaat aatttttatc cacgggaggc caaggtgcag      120

tggaaggtgg acaatgccct gcagtctggg aactctcaag agagtgtgac agagcaggac      180

agtaaagaca gcacctatag cctcagcagc accctgaccc tgtctaaagc cgactatgaa      240

aaacacaaag tgtatgcctg cgaagtgacc catcaggggc tcagctctcc cgttaccaag      300

agctttaacc gaggcgaatg t                                                321


<210>  34
<211>  107
<212>  PRT
<213>  Homo

<400>  34

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  35
<211>  642
<212>  DNA
<213>  Synthetic

<400>  35
gacatccaga tgacccagtc cccttcctcc ctgtccgctt ccgtgggcga cagggtgacc       60

atcacctgta gggcctccca ggacatcggc tccaggctga actggctgca gcagaagccc      120

ggcaagtcca tcaagcggct gatctacgcc acctcctccc tggagtccgg cgtgccttcc      180

aggttctccg gctccaggtc cggctccgac tacaccctga ccatctcctc cctgcagccc      240

gaggacttcg ccacctacta ctgcctgcag tccggctcct cccctcctac cttcggccag      300

ggcaccaagg tggagatcaa gcgcactgtg gctgccccca gtgttttcat atttcccccc      360

agtgatgagc aactgaagtc cggcacagcc tctgttgtat gtctgctgaa taatttttat      420

ccacgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagtctgg gaactctcaa      480

gagagtgtga cagagcagga cagtaaagac agcacctata gcctcagcag caccctgacc      540

ctgtctaaag ccgactatga aaaacacaaa gtgtatgcct gcgaagtgac ccatcagggg      600

ctcagctctc ccgttaccaa gagctttaac cgaggcgaat gt                         642


<210>  36
<211>  214
<212>  PRT
<213>  Synthetic

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ser Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Gly Ser Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  37
<211>  1329
<212>  DNA
<213>  Synthetic

<400>  37
gaagtgcagc tggtggagtc cggaggcgga ctggtgaagc ctggaggctc cctgaggctg       60

tcctgtgccg cttccggctt caccttctcc gacgactaca tggcctggtt caggcaggcc      120

cctggaaaga ggctggagtg ggtggcttcc atctcccacg gcggcgacta catctactac      180

gccgacaacc tgaagggcag gttcaccatc tccagggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgag ggccgaggac accgccgtgt acttctgctc cagggacagg      300

aggtccatcg actattgggg ccagggcacc ctggtgacag tgtcctccgc aagtaccaag      360

ggacctagtg ttttccctct tgcaccttgc tccaggtcaa catcagagtc cacagctgct      420

cttggatgtc tcgttaagga ctacttccca gagccagtta ccgtatcctg gaactccgga      480

gctttgacaa gcggcgttca tacattccca gctgtgttgc agagttctgg gttgtacagt      540

ttgagctcag tggtgaccgt gccttcatct tctttgggca ctaagaccta cacctgcaac      600

gtggatcaca agccaagcaa caccaaggtg gataagaggg tggagtccaa gtacggccca      660

ccatgtcctc catgtccagc ccctgaattt ttgggcgggc cttctgtctt tctgtttcct      720

cctaaaccta aagataccct gatgatcagc cgcacacccg aagtcacttg tgtggtcgtg      780

gatgtgtctc aggaagatcc cgaagtgcag tttaactggt atgtcgatgg cgtggaagtg      840

cataatgcca aaactaagcc ccgcgaagaa cagttcaaca gcacttatcg ggtcgtgtct      900

gtgctcacag tcctccatca ggattggctg aatgggaaag aatataagtg caaggtgagc      960

aataagggcc tccccagcag catcgagaag actattagca aagccaaagg gcagccacgg     1020

gaaccccagg tgtacactct gcccccctct caggaggaga tgactaaaaa tcaggtctct     1080

ctgacttgtc tggtgaaagg gttttatccc agcgacattg ccgtggagtg ggagtctaat     1140

ggccagcccg agaataatta taagacaact ccccccgtcc tggactctga cggcagcttt     1200

ttcctgtatt ctcggctgac agtggacaaa agtcgctggc aggagggcaa tgtctttagt     1260

tgcagtgtca tgcatgaggc cctgcacaat cactatacac agaaaagcct gtctctgagt     1320

ctgggcaaa                                                             1329


<210>  38
<211>  443
<212>  PRT
<213>  Synthetic

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser His Gly Gly Asp Tyr Ile Tyr Tyr Ala Asp Asn Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ser Arg Asp Arg Arg Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             


<210>  39
<211>  642
<212>  DNA
<213>  Synthetic

<400>  39
gacatccaga tgacccagtc cccttcctcc ctgtccgctt ccgtgggcga cagggtgacc       60

atcacctgca gggccagcca ggacatctcc aactacctgt cctggtacca gcagaagccc      120

ggcaagacca tcaagctgct gatctactac acctccaggc tgcacagcgg cgtgcctagc      180

aggttctccg gttctggctc cggcaccgac tacaccttca ccatcagctc cctgcagccc      240

gaggacatcg ccacctactt ctgccagcag ggcaagaccc tgccctacac cttcggccag      300

ggcaccaagg tggagatcaa gcgcactgtg gctgccccca gtgttttcat atttcccccc      360

agtgatgagc aactgaagtc cggcacagcc tctgttgtat gtctgctgaa taatttttat      420

ccacgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagtctgg gaactctcaa      480

gagagtgtga cagagcagga cagtaaagac agcacctata gcctcagcag caccctgacc      540

ctgtctaaag ccgactatga aaaacacaaa gtgtatgcct gcgaagtgac ccatcagggg      600

ctcagctctc ccgttaccaa gagctttaac cgaggcgaat gt                         642


<210>  40
<211>  214
<212>  PRT
<213>  Synthetic

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  41
<211>  422
<212>  PRT
<213>  Homo

<400>  41

Val Pro Val Val Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys 
1               5                   10                  15      


Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly 
            20                  25                  30          


Val Thr Trp Gln His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro 
        35                  40                  45              


Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp 
    50                  55                  60                  


Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly 
65                  70                  75                  80  


Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu 
                85                  90                  95      


Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg 
            100                 105                 110         


Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg 
        115                 120                 125             


Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr 
    130                 135                 140                 


Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn 
145                 150                 155                 160 


Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg 
                165                 170                 175     


Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His His 
            180                 185                 190         


Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser 
        195                 200                 205             


Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser 
    210                 215                 220                 


Ile Met Tyr Asn Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu 
225                 230                 235                 240 


Thr Val Tyr Ala Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu 
                245                 250                 255     


Pro Ala Gly Val Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro 
            260                 265                 270         


Pro Gly Gly Gly Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe 
        275                 280                 285             


Thr Leu Arg Leu Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr 
    290                 295                 300                 


Cys His Ile His Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu 
305                 310                 315                 320 


Ala Ile Ile Thr Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu 
                325                 330                 335     


Gly Lys Leu Leu Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe 
            340                 345                 350         


Val Trp Ser Ser Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro 
        355                 360                 365             


Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys 
    370                 375                 380                 


Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr 
385                 390                 395                 400 


Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala 
                405                 410                 415     


Leu Pro Ala Gly His Leu 
            420         


<210>  42
<211>  17
<212>  PRT
<213>  Synthetic

<400>  42

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  43
<211>  9
<212>  PRT
<213>  Synthetic

<400>  43

Leu Gln Ser Gly Ser Ser Pro Pro Thr 
1               5                   


<210>  44
<211>  10
<212>  PRT
<213>  Synthetic

<400>  44

Trp Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Synthetic

<400>  45

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  46
<211>  30
<212>  PRT
<213>  Homo

<400>  46

Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala Pro Gly Pro His 
1               5                   10                  15      


Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg Arg Tyr 
            20                  25                  30  


<210>  47
<211>  9
<212>  PRT
<213>  Homo

<400>  47

Pro His Pro Ala Ala Pro Ser Ser Trp 
1               5                   


<210>  48
<211>  12
<212>  PRT
<213>  Homo

<400>  48

Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala 
1               5                   10          


<210>  49
<211>  19
<212>  PRT
<213>  Homo

<400>  49

Ala Ala Ala Pro Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala 
1               5                   10                  15      


Pro Ser Ser 
            


<210>  50
<211>  9
<212>  PRT
<213>  Homo

<400>  50

Ala Ala Ala Pro Gly His Pro Leu Ala 
1               5                   


<210>  51
<211>  232
<212>  PRT
<213>  Homo

<400>  51

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  52
<211>  233
<212>  PRT
<213>  Staphylococcus

<400>  52

Ser Glu Lys Ser Glu Glu Ile Asn Glu Lys Asp Leu Arg Lys Lys Ser 
1               5                   10                  15      


Glu Leu Gln Gly Thr Ala Leu Gly Asn Leu Lys Gln Ile Tyr Tyr Tyr 
            20                  25                  30          


Asn Glu Lys Ala Lys Thr Glu Asn Lys Glu Ser His Asp Gln Phe Leu 
        35                  40                  45              


Gln His Thr Ile Leu Phe Lys Gly Phe Phe Thr Asp His Ser Trp Tyr 
    50                  55                  60                  


Asn Asp Leu Leu Val Asp Phe Asp Ser Lys Asp Ile Val Asp Lys Tyr 
65                  70                  75                  80  


Lys Gly Lys Lys Val Asp Leu Tyr Gly Ala Tyr Tyr Gly Tyr Gln Cys 
                85                  90                  95      


Ala Gly Gly Thr Pro Asn Lys Thr Ala Cys Met Tyr Gly Gly Val Thr 
            100                 105                 110         


Leu His Asp Asn Asn Arg Leu Thr Glu Glu Lys Lys Val Pro Ile Asn 
        115                 120                 125             


Leu Trp Leu Asp Gly Lys Gln Asn Thr Val Pro Leu Glu Thr Val Lys 
    130                 135                 140                 


Thr Asn Lys Lys Asn Val Thr Val Gln Glu Leu Asp Leu Gln Ala Arg 
145                 150                 155                 160 


Arg Tyr Leu Gln Glu Lys Tyr Asn Leu Tyr Asn Ser Asp Val Phe Asp 
                165                 170                 175     


Gly Lys Val Gln Arg Gly Leu Ile Val Phe His Thr Ser Thr Glu Pro 
            180                 185                 190         


Ser Val Asn Tyr Asp Leu Phe Gly Ala Gln Gly Gln Tyr Ser Asn Thr 
        195                 200                 205             


Leu Leu Arg Ile Tyr Arg Asp Asn Lys Thr Ile Asn Ser Glu Asn Met 
    210                 215                 220                 


His Ile Asp Ile Tyr Leu Tyr Thr Ser 
225                 230             


<210>  53
<211>  290
<212>  PRT
<213>  Homo

<400>  53

Leu Glu Asp Cys Ala Gln Glu Gln Met Arg Leu Arg Ala Gln Val Arg 
1               5                   10                  15      


Leu Leu Glu Thr Arg Val Lys Gln Gln Gln Val Lys Ile Lys Gln Leu 
            20                  25                  30          


Leu Gln Glu Asn Glu Val Gln Phe Leu Asp Lys Gly Asp Glu Asn Thr 
        35                  40                  45              


Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr Ala Asp Cys Ser Glu Ile 
    50                  55                  60                  


Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe Tyr Lys Ile Lys Pro Leu 
65                  70                  75                  80  


Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys Asp Met Ser Asp Gly Gly 
                85                  90                  95      


Gly Trp Thr Val Ile Gln Arg Arg Ser Asp Gly Ser Glu Asn Phe Asn 
            100                 105                 110         


Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe Gly Asn Phe Val Gln Lys 
        115                 120                 125             


His Gly Glu Tyr Trp Leu Gly Asn Lys Asn Leu His Phe Leu Thr Thr 
    130                 135                 140                 


Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu Ala Asp Phe Glu Lys Asn 
145                 150                 155                 160 


Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys Val Gly Asp Glu Lys Asn 
                165                 170                 175     


Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser Gly Thr Ala Gly Asp Ser 
            180                 185                 190         


Leu Ala Gly Asn Phe His Pro Glu Val Gln Trp Trp Ala Ser His Gln 
        195                 200                 205             


Arg Met Lys Phe Ser Thr Trp Asp Arg Asp His Asp Asn Tyr Glu Gly 
    210                 215                 220                 


Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp Trp Phe Asn Arg Cys His 
225                 230                 235                 240 


Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser Gly Pro Tyr Thr Ala Lys 
                245                 250                 255     


Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp His Gly Trp Trp Tyr Ser 
            260                 265                 270         


Leu Lys Ser Val Val Met Lys Ile Arg Pro Asn Asp Phe Ile Pro Asn 
        275                 280                 285             


Val Ile 
    290 
