﻿                         序列表

<110>  南京大学

<120>  兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用

<130>  2019

<160>  10

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  385
<212>  PRT
<213>  mouse（Mus musculus）

<400>  1
Met Trp Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      
Leu Ser Trp Gln Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp 
            20                  25                  30          
Arg Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala 
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met 
    50                  55                  60                  
Leu Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala 
65                  70                  75                  80  
Ala Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln 
                85                  90                  95      
Ile Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp 
            100                 105                 110         
Thr Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             
His Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val 
    130                 135                 140                 
Thr Glu Arg Ile Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro 
145                 150                 155                 160 
Lys Pro Glu Gly Arg Phe Gln Gly Met Val Gly Gly Gly Gly Ser Gly 
                165                 170                 175     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Thr Ile Thr Thr Ser 
            180                 185                 190         
Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val 
        195                 200                 205             
Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe 
    210                 215                 220                 
Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu 
225                 230                 235                 240 
Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly 
                245                 250                 255     
Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly 
            260                 265                 270         
Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn 
        275                 280                 285             
Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys 
    290                 295                 300                 
Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe 
305                 310                 315                 320 
Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu 
                325                 330                 335     
Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr 
            340                 345                 350         
Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro 
        355                 360                 365             
Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp 
    370                 375                 380                 
Glu 
385 

<210>  2
<211>  170
<212>  PRT
<213>  mouse（Mus musculus）

<400>  2
Met Trp Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      
Leu Ser Trp Gln Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp 
            20                  25                  30          
Arg Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala 
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met 
    50                  55                  60                  
Leu Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala 
65                  70                  75                  80  
Ala Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln 
                85                  90                  95      
Ile Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp 
            100                 105                 110         
Thr Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             
His Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val 
    130                 135                 140                 
Thr Glu Arg Ile Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro 
145                 150                 155                 160 
Lys Pro Glu Gly Arg Phe Gln Gly Met Val 
                165                 170 

<210>  3
<211>  200
<212>  PRT
<213>  mouse（Mus musculus）

<400>  3
Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn 
1               5                   10                  15      
Ala Asp Gln Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr 
            20                  25                  30          
Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala 
        35                  40                  45              
Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly 
    50                  55                  60                  
Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu 
65                  70                  75                  80  
Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys 
                85                  90                  95      
Leu Ser Pro Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val 
            100                 105                 110         
Ser Leu Val Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu 
        115                 120                 125             
Ala Leu Thr Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val 
    130                 135                 140                 
Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu 
145                 150                 155                 160 
Ser Val Gly Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg 
                165                 170                 175     
Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu 
            180                 185                 190         
Val Lys Pro Asp Asn Pro Trp Glu 
        195                 200 

<210>  4
<211>  15
<212>  PRT
<213>  人工序列(Mus musculus)

<400>  4
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210>  5
<211>  16
<212>  PRT
<213>  mouse（Mus musculus）

<400>  5
Met Leu Trp Pro Leu Pro Leu Phe Leu Leu Cys Ala Gly Ser Leu Ala 
1               5                   10                  15      

<210>  6
<211>  510
<212>  DNA
<213>  mouse（Mus musculus）

<400>  6
atgtgggtcc ggcaggtacc ctggtcattc acttgggctg tgctgcagtt gagctggcaa        60
tcagggtggc ttctagaggt ccccaatggg ccctggaggt ccctcacctt ctacccagcc       120
tggctcacag tgtcagaggg agcaaatgcc accttcacct gcagcttgtc caactggtcg       180
gaggatctta tgctgaactg gaaccgcctg agtcccagca accagactga aaaacaggcc       240
gccttctgta atggtttgag ccaacccgtc caggatgccc gcttccagat catacagctg       300
cccaacaggc atgacttcca catgaacatc cttgacacac ggcgcaatga cagtggcatc       360
tacctctgtg gggccatctc cctgcacccc aaggcaaaaa tcgaggagag ccctggagca       420
gagctcgtgg taacagagag aatcctggag acctcaacaa gatatcccag cccctcgccc       480
aaaccagaag gccggtttca aggcatggtc                                        510

<210>  7
<211>  600
<212>  DNA
<213>  mouse（Mus musculus）

<400>  7
gcgctcacaa tcaccacctc gcccaacctg ggtacccgag agaataatgc agaccaggtc        60
acccctgttt cccacattgg ctgccccaac actacacaac agggctctcc tgtgttcgcc       120
aagctactgg ctaaaaacca agcatcgttg tgcaatacaa ctctgaactg gcacagccaa       180
gatggagctg ggagctcata cctatctcaa ggtctgaggt acgaagaaga caaaaaggag       240
ttggtggtag acagtcccgg gctctactac gtatttttgg aactgaagct cagtccaaca       300
ttcacaaaca caggccacaa ggtgcagggc tgggtctctc ttgttttgca agcaaagcct       360
caggtagatg actttgacaa cttggccctg acagtggaac tgttcccttg ctccatggag       420
aacaagttag tggaccgttc ctggagtcaa ctgttgctcc tgaaggctgg ccaccgcctc       480
agtgtgggtc tgagggctta tctgcatgga gcccaggatg catacagaga ctgggagctg       540
tcttatccca acaccaccag ctttggactc tttcttgtga aacccgacaa cccatgggaa       600

<210>  8
<211>  45
<212>  DNA
<213>  人工序列(Mus musculus)

<400>  8
ggtggaggcg gttcaggcgg aggtggctct ggcggtggcg gatcg                        45

<210>  9
<211>  1155
<212>  DNA
<213>  mouse（Mus musculus）

<400>  9
atgtgggtcc ggcaggtacc ctggtcattc acttgggctg tgctgcagtt gagctggcaa        60
tcagggtggc ttctagaggt ccccaatggg ccctggaggt ccctcacctt ctacccagcc       120
tggctcacag tgtcagaggg agcaaatgcc accttcacct gcagcttgtc caactggtcg       180
gaggatctta tgctgaactg gaaccgcctg agtcccagca accagactga aaaacaggcc       240
gccttctgta atggtttgag ccaacccgtc caggatgccc gcttccagat catacagctg       300
cccaacaggc atgacttcca catgaacatc cttgacacac ggcgcaatga cagtggcatc       360
tacctctgtg gggccatctc cctgcacccc aaggcaaaaa tcgaggagag ccctggagca       420
gagctcgtgg taacagagag aatcctggag acctcaacaa gatatcccag cccctcgccc       480
aaaccagaag gccggtttca aggcatggtc ggtggaggcg gttcaggcgg aggtggctct       540
ggcggtggcg gatcggcgct cacaatcacc acctcgccca acctgggtac ccgagagaat       600
aatgcagacc aggtcacccc tgtttcccac attggctgcc ccaacactac acaacagggc       660
tctcctgtgt tcgccaagct actggctaaa aaccaagcat cgttgtgcaa tacaactctg       720
aactggcaca gccaagatgg agctgggagc tcatacctat ctcaaggtct gaggtacgaa       780
gaagacaaaa aggagttggt ggtagacagt cccgggctct actacgtatt tttggaactg       840
aagctcagtc caacattcac aaacacaggc cacaaggtgc agggctgggt ctctcttgtt       900
ttgcaagcaa agcctcaggt agatgacttt gacaacttgg ccctgacagt ggaactgttc       960
ccttgctcca tggagaacaa gttagtggac cgttcctgga gtcaactgtt gctcctgaag      1020
gctggccacc gcctcagtgt gggtctgagg gcttatctgc atggagccca ggatgcatac      1080
agagactggg agctgtctta tcccaacacc accagctttg gactctttct tgtgaaaccc      1140
gacaacccat gggaa                                                       1155

<210>  10
<211>  48
<212>  DNA
<213>  mouse（Mus musculus）

<400>  10
atgctgtggc cactgccgct gttcttgctg tgtgcaggct ccctggct                     48

