                         SEQUENCE LISTING

<110>  University of Saskatchewan
 
<120>  LAWSONIA INTRACELLULARIS COMPOSITIONS AND METHODS OF USING THE 
       SAME

<130>  08942125WO

<140>  PCT/CA2020/050277
<141>  2020-02-28

<150>  US 62/811,974
<151>  2019-02-28

<160>  78    


<170>  PatentIn version 3.5

<210>  1
<211>  882
<212>  DNA
<213>  Lawsonia intracellularis

<400>  1
atgtctcttg tcattaataa caacctgatg gccgtcaatg ctcaacgtaa cttaagcaag       60

tcttatggag aactgagttc ttctgttcga aaactttctt caggtcttcg tgtaggaact      120

gctgctgatg actcagcagg gttagccatt cgagaactca tgagatctga cattgcaaca      180

acacaacaag gaatacgaaa tgcgaatgat gctatttcta tgattcaaac tgcggatggt      240

gcacttggag tcatcgatga aaagctcatt cgaatgaaag aacttgctga acaagctgct      300

acaggtacat ataactccac tcagcgtatg attattgact ctgaatatca agctatggcc      360

tcagaaatta ctcgtattgc taatgcgaca gaatttaatg gtataaaact tcttgatggt      420

tcattatcag gtaatcatga tgggaaaaaa ataaattcaa ctggtgcagt acgtatccac      480

tttgggacat ctaacagctc tgctgaagat tactatgata ttaaaattgg tggctctaca      540

gcttctgcat taggacttgg taatacagta aaaggtgcgg gtgctacagt ctctactcaa      600

gctgcagcac aaaatgcctt aaaagctata gataatgcca ttgtttcaaa agataaaatt      660

cgagcacacc ttggtggatt acaaaataga cttgaagcta cagttgataa tttaagtata      720

caaaatgaaa acttacaagc tgctgaatct cgtatatctg atatagatgt aagccaagaa      780

atgacacaat ttgtacgtaa ccaaatactt acacaaacag gtgttgctat gctttcacaa      840

gctaattctc taccacgtat ggctcagcaa cttattggct aa                         882


<210>  2
<211>  293
<212>  PRT
<213>  Lawsonia intracellularis

<400>  2

Met Ser Leu Val Ile Asn Asn Asn Leu Met Ala Val Asn Ala Gln Arg 
1               5                   10                  15      


Asn Leu Ser Lys Ser Tyr Gly Glu Leu Ser Ser Ser Val Arg Lys Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Val Gly Thr Ala Ala Asp Asp Ser Ala Gly Leu 
        35                  40                  45              


Ala Ile Arg Glu Leu Met Arg Ser Asp Ile Ala Thr Thr Gln Gln Gly 
    50                  55                  60                  


Ile Arg Asn Ala Asn Asp Ala Ile Ser Met Ile Gln Thr Ala Asp Gly 
65                  70                  75                  80  


Ala Leu Gly Val Ile Asp Glu Lys Leu Ile Arg Met Lys Glu Leu Ala 
                85                  90                  95      


Glu Gln Ala Ala Thr Gly Thr Tyr Asn Ser Thr Gln Arg Met Ile Ile 
            100                 105                 110         


Asp Ser Glu Tyr Gln Ala Met Ala Ser Glu Ile Thr Arg Ile Ala Asn 
        115                 120                 125             


Ala Thr Glu Phe Asn Gly Ile Lys Leu Leu Asp Gly Ser Leu Ser Gly 
    130                 135                 140                 


Asn His Asp Gly Lys Lys Ile Asn Ser Thr Gly Ala Val Arg Ile His 
145                 150                 155                 160 


Phe Gly Thr Ser Asn Ser Ser Ala Glu Asp Tyr Tyr Asp Ile Lys Ile 
                165                 170                 175     


Gly Gly Ser Thr Ala Ser Ala Leu Gly Leu Gly Asn Thr Val Lys Gly 
            180                 185                 190         


Ala Gly Ala Thr Val Ser Thr Gln Ala Ala Ala Gln Asn Ala Leu Lys 
        195                 200                 205             


Ala Ile Asp Asn Ala Ile Val Ser Lys Asp Lys Ile Arg Ala His Leu 
    210                 215                 220                 


Gly Gly Leu Gln Asn Arg Leu Glu Ala Thr Val Asp Asn Leu Ser Ile 
225                 230                 235                 240 


Gln Asn Glu Asn Leu Gln Ala Ala Glu Ser Arg Ile Ser Asp Ile Asp 
                245                 250                 255     


Val Ser Gln Glu Met Thr Gln Phe Val Arg Asn Gln Ile Leu Thr Gln 
            260                 265                 270         


Thr Gly Val Ala Met Leu Ser Gln Ala Asn Ser Leu Pro Arg Met Ala 
        275                 280                 285             


Gln Gln Leu Ile Gly 
    290             


<210>  3
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  3

Met His His His His His His Gly Ser Ser Leu Val Ile Asn Asn Asn 
1               5                   10                  15      


Leu Met Ala Val Asn Ala Gln Arg Asn Leu Ser Lys Ser Tyr Gly Glu 
            20                  25                  30          


Leu Ser Ser Ser Val Arg Lys Leu Ser Ser Gly Leu Arg Val Gly Thr 
        35                  40                  45              


Ala Ala Asp Asp Ser Ala Gly Leu Ala Ile Arg Glu Leu Met Arg Ser 
    50                  55                  60                  


Asp Ile Ala Thr Thr Gln Gln Gly Ile Arg Asn Ala Asn Asp Ala Ile 
65                  70                  75                  80  


Ser Met Ile Gln Thr Ala Asp Gly Ala Leu Gly Val Ile Asp Glu Lys 
                85                  90                  95      


Leu Ile Arg Met Lys Glu Leu Ala Glu Gln Ala Ala Thr Gly Thr Tyr 
            100                 105                 110         


Asn Ser Thr Gln Arg Met Ile Ile Asp Ser Glu Tyr Gln Ala Met Ala 
        115                 120                 125             


Ser Glu Ile Thr Arg Ile Ala Asn Ala Thr Glu Phe Asn Gly Ile Lys 
    130                 135                 140                 


Leu Leu Asp Gly Ser Leu Ser Gly Asn His Asp Gly Lys Lys Ile Asn 
145                 150                 155                 160 


Ser Thr Gly Ala Val Arg Ile His Phe Gly Thr Ser Asn Ser Ser Ala 
                165                 170                 175     


Glu Asp Tyr Tyr Asp Ile Lys Ile Gly Gly Ser Thr Ala Ser Ala Leu 
            180                 185                 190         


Gly Leu Gly Asn Thr Val Lys Gly Ala Gly Ala Thr Val Ser Thr Gln 
        195                 200                 205             


Ala Ala Ala Gln Asn Ala Leu Lys Ala Ile Asp Asn Ala Ile Val Ser 
    210                 215                 220                 


Lys Asp Lys Ile Arg Ala His Leu Gly Gly Leu Gln Asn Arg Leu Glu 
225                 230                 235                 240 


Ala Thr Val Asp Asn Leu Ser Ile Gln Asn Glu Asn Leu Gln Ala Ala 
                245                 250                 255     


Glu Ser Arg Ile Ser Asp Ile Asp Val Ser Gln Glu Met Thr Gln Phe 
            260                 265                 270         


Val Arg Asn Gln Ile Leu Thr Gln Thr Gly Val Ala Met Leu Ser Gln 
        275                 280                 285             


Ala Asn Ser Leu Pro Arg Met Ala Gln Gln Leu Ile Gly 
    290                 295                 300     


<210>  4
<211>  2556
<212>  DNA
<213>  Lawsonia intracellularis

<400>  4
atggcatacc tatctatttc aaaaaatcaa tgtaagtctt ttttaataac tctagtaact       60

atatttataa tgacatcaat accacaacta gctgaggctg ttgaacactt tgctaatggt      120

gtccccacag tagtacaaga tgttaatgtc ccagctgact catactttgg tggtgctgac      180

tcagctgtag gtccaaaccc aatagcttct actcacctta caatttctac aactcaaggg      240

tttggacaaa atgcactaga atttgttgtg ggtggtagcc ttgcaaatgg taatggaaat      300

ccagccaaca taaatggaga tatagtcctt attgttgaaa atacaaatac tcagaatagt      360

attattggtg gtagtatggc aaatgctgcc cctgtaacta ttggtggctc tatttttatg      420

actcttagaa atgttactgc agtagatcca atttttggtg gctctgtaga tgtacgcttt      480

ttcgcccaac agcaacctaa tgaggatcaa cttgtaggtg gagatattaa tataaatcta      540

gagaatgtaa caactccaga gttttatggt ctaggctacg caaatggtgt aatacctgtt      600

aacgtcctca atagaaattt tttggtagct gttcagggaa atataactac aaatatttct      660

aattctaaca ttgcaaccgt tatgttaggt tcacactatg atacaactat ggctgtagga      720

ggtaatggaa caataaatgt tgataattca acaattggtt atctttcagc tagcaatagt      780

agcgactttg ttaaccctga cttaacaaac actgttactt ttaatattgg tcccaacaac      840

agaatagcaa atatttttgc aagcaataat ggtgttatcc cacattttat tgtaaatatg      900

gatggatctg gaacagaaat acaagagtta acacttggta atgtaattcg aggtggcctt      960

gtacttactt cagagctaaa tctatctcaa ggaacaataa ataatttaat cactggtaat     1020

gaatattacg atagatcagg attaagaact actgtaaatg ttagaggagg tacaattggc     1080

gtattgactt caggaggttc tgactattca gaattaaact tcattcctgg agaaatatcc     1140

actatattag caacaaattc aataggtaac caagattttg catctctttc tcaagttaca     1200

atacaccaag gtgctgaaac tctttgggga atgagagatg aagtatttga acttcaaact     1260

aacaatctac agttaggtgg tgaactattt attcctgctg atggaactgg aggagtagcc     1320

ctaatcacaa atcatattat tgcaaattca ggtgtgataa ctccggtaaa tatgtctcca     1380

gaaaggatga cccctatcat tggattttta gaacctactg gtgaggtagc acagttaaca     1440

atatatggac cacttacagt taaccttagc cattctccag aaattcttgg gaaaattatt     1500

acacaaccta tccctattgc agttactaat agtgatgttt ttggtacttc taaactattt     1560

gtggaacata acacaaaagg actaatttgg agtgatatca tttttaatcc tcaagataaa     1620

acatggtatc taactaactt tagaggttct gaagacttct acggactttc agcagcacgg     1680

gaagcatcta attggttaag acaacaacat atctggagcc tacaacgtcg ctctaataaa     1740

ttattagatc atggtgtaga tgggttatgg atgaatgttc aaggtggtta tgaaaagctt     1800

gatgcagcaa ttggtgatgc taagatgcct tggattatgg caagcttagg atatgatttt     1860

atgcataagt taagtgattt ttataactta aaagcacttt atggattcgg atttggattt     1920

gctacaggta aaaataaatg gaataccata aactcaacta ctaatgatat ctacatgggg     1980

ctggttggtg cctatgttgg ccttatgcat gaagccacag gcctttatgg tacagtatcc     2040

ggacagtttg caactaaccg tacaaaaaca aaatgtacag gctttgatga aacctataac     2100

tggaaagaaa atgtaccaac agaagctatt gaaattggtt ggaaatggag cattgatgag     2160

tttaaaataa acccacgtgg acaagttatt tttgaacaat tatctaaaca tcactttagt     2220

ctctcacaag aaggtgatac tgctatctta gataaagaat tcttaactac aaccgttata     2280

ggtatctctg gagaatatga tttagattta agaagtaaaa taataaagct tcaagctagt     2340

gttgactgga ttaaaggcat ctctggtgac tttgcagcta aatccgaagt tcttaatatg     2400

aagtttaaag ataaaaatga tactagtaca tttagaggaa cactgggtgc tagtgcacaa     2460

cttctagaaa actttgaagt tcaccttgat atttttggtg atcttggcaa tgataaaggt     2520

attggtggac aggtaggagc tacttataga ttctaa                               2556


<210>  5
<211>  851
<212>  PRT
<213>  Lawsonia intracellularis

<400>  5

Met Ala Tyr Leu Ser Ile Ser Lys Asn Gln Cys Lys Ser Phe Leu Ile 
1               5                   10                  15      


Thr Leu Val Thr Ile Phe Ile Met Thr Ser Ile Pro Gln Leu Ala Glu 
            20                  25                  30          


Ala Val Glu His Phe Ala Asn Gly Val Pro Thr Val Val Gln Asp Val 
        35                  40                  45              


Asn Val Pro Ala Asp Ser Tyr Phe Gly Gly Ala Asp Ser Ala Val Gly 
    50                  55                  60                  


Pro Asn Pro Ile Ala Ser Thr His Leu Thr Ile Ser Thr Thr Gln Gly 
65                  70                  75                  80  


Phe Gly Gln Asn Ala Leu Glu Phe Val Val Gly Gly Ser Leu Ala Asn 
                85                  90                  95      


Gly Asn Gly Asn Pro Ala Asn Ile Asn Gly Asp Ile Val Leu Ile Val 
            100                 105                 110         


Glu Asn Thr Asn Thr Gln Asn Ser Ile Ile Gly Gly Ser Met Ala Asn 
        115                 120                 125             


Ala Ala Pro Val Thr Ile Gly Gly Ser Ile Phe Met Thr Leu Arg Asn 
    130                 135                 140                 


Val Thr Ala Val Asp Pro Ile Phe Gly Gly Ser Val Asp Val Arg Phe 
145                 150                 155                 160 


Phe Ala Gln Gln Gln Pro Asn Glu Asp Gln Leu Val Gly Gly Asp Ile 
                165                 170                 175     


Asn Ile Asn Leu Glu Asn Val Thr Thr Pro Glu Phe Tyr Gly Leu Gly 
            180                 185                 190         


Tyr Ala Asn Gly Val Ile Pro Val Asn Val Leu Asn Arg Asn Phe Leu 
        195                 200                 205             


Val Ala Val Gln Gly Asn Ile Thr Thr Asn Ile Ser Asn Ser Asn Ile 
    210                 215                 220                 


Ala Thr Val Met Leu Gly Ser His Tyr Asp Thr Thr Met Ala Val Gly 
225                 230                 235                 240 


Gly Asn Gly Thr Ile Asn Val Asp Asn Ser Thr Ile Gly Tyr Leu Ser 
                245                 250                 255     


Ala Ser Asn Ser Ser Asp Phe Val Asn Pro Asp Leu Thr Asn Thr Val 
            260                 265                 270         


Thr Phe Asn Ile Gly Pro Asn Asn Arg Ile Ala Asn Ile Phe Ala Ser 
        275                 280                 285             


Asn Asn Gly Val Ile Pro His Phe Ile Val Asn Met Asp Gly Ser Gly 
    290                 295                 300                 


Thr Glu Ile Gln Glu Leu Thr Leu Gly Asn Val Ile Arg Gly Gly Leu 
305                 310                 315                 320 


Val Leu Thr Ser Glu Leu Asn Leu Ser Gln Gly Thr Ile Asn Asn Leu 
                325                 330                 335     


Ile Thr Gly Asn Glu Tyr Tyr Asp Arg Ser Gly Leu Arg Thr Thr Val 
            340                 345                 350         


Asn Val Arg Gly Gly Thr Ile Gly Val Leu Thr Ser Gly Gly Ser Asp 
        355                 360                 365             


Tyr Ser Glu Leu Asn Phe Ile Pro Gly Glu Ile Ser Thr Ile Leu Ala 
    370                 375                 380                 


Thr Asn Ser Ile Gly Asn Gln Asp Phe Ala Ser Leu Ser Gln Val Thr 
385                 390                 395                 400 


Ile His Gln Gly Ala Glu Thr Leu Trp Gly Met Arg Asp Glu Val Phe 
                405                 410                 415     


Glu Leu Gln Thr Asn Asn Leu Gln Leu Gly Gly Glu Leu Phe Ile Pro 
            420                 425                 430         


Ala Asp Gly Thr Gly Gly Val Ala Leu Ile Thr Asn His Ile Ile Ala 
        435                 440                 445             


Asn Ser Gly Val Ile Thr Pro Val Asn Met Ser Pro Glu Arg Met Thr 
    450                 455                 460                 


Pro Ile Ile Gly Phe Leu Glu Pro Thr Gly Glu Val Ala Gln Leu Thr 
465                 470                 475                 480 


Ile Tyr Gly Pro Leu Thr Val Asn Leu Ser His Ser Pro Glu Ile Leu 
                485                 490                 495     


Gly Lys Ile Ile Thr Gln Pro Ile Pro Ile Ala Val Thr Asn Ser Asp 
            500                 505                 510         


Val Phe Gly Thr Ser Lys Leu Phe Val Glu His Asn Thr Lys Gly Leu 
        515                 520                 525             


Ile Trp Ser Asp Ile Ile Phe Asn Pro Gln Asp Lys Thr Trp Tyr Leu 
    530                 535                 540                 


Thr Asn Phe Arg Gly Ser Glu Asp Phe Tyr Gly Leu Ser Ala Ala Arg 
545                 550                 555                 560 


Glu Ala Ser Asn Trp Leu Arg Gln Gln His Ile Trp Ser Leu Gln Arg 
                565                 570                 575     


Arg Ser Asn Lys Leu Leu Asp His Gly Val Asp Gly Leu Trp Met Asn 
            580                 585                 590         


Val Gln Gly Gly Tyr Glu Lys Leu Asp Ala Ala Ile Gly Asp Ala Lys 
        595                 600                 605             


Met Pro Trp Ile Met Ala Ser Leu Gly Tyr Asp Phe Met His Lys Leu 
    610                 615                 620                 


Ser Asp Phe Tyr Asn Leu Lys Ala Leu Tyr Gly Phe Gly Phe Gly Phe 
625                 630                 635                 640 


Ala Thr Gly Lys Asn Lys Trp Asn Thr Ile Asn Ser Thr Thr Asn Asp 
                645                 650                 655     


Ile Tyr Met Gly Leu Val Gly Ala Tyr Val Gly Leu Met His Glu Ala 
            660                 665                 670         


Thr Gly Leu Tyr Gly Thr Val Ser Gly Gln Phe Ala Thr Asn Arg Thr 
        675                 680                 685             


Lys Thr Lys Cys Thr Gly Phe Asp Glu Thr Tyr Asn Trp Lys Glu Asn 
    690                 695                 700                 


Val Pro Thr Glu Ala Ile Glu Ile Gly Trp Lys Trp Ser Ile Asp Glu 
705                 710                 715                 720 


Phe Lys Ile Asn Pro Arg Gly Gln Val Ile Phe Glu Gln Leu Ser Lys 
                725                 730                 735     


His His Phe Ser Leu Ser Gln Glu Gly Asp Thr Ala Ile Leu Asp Lys 
            740                 745                 750         


Glu Phe Leu Thr Thr Thr Val Ile Gly Ile Ser Gly Glu Tyr Asp Leu 
        755                 760                 765             


Asp Leu Arg Ser Lys Ile Ile Lys Leu Gln Ala Ser Val Asp Trp Ile 
    770                 775                 780                 


Lys Gly Ile Ser Gly Asp Phe Ala Ala Lys Ser Glu Val Leu Asn Met 
785                 790                 795                 800 


Lys Phe Lys Asp Lys Asn Asp Thr Ser Thr Phe Arg Gly Thr Leu Gly 
                805                 810                 815     


Ala Ser Ala Gln Leu Leu Glu Asn Phe Glu Val His Leu Asp Ile Phe 
            820                 825                 830         


Gly Asp Leu Gly Asn Asp Lys Gly Ile Gly Gly Gln Val Gly Ala Thr 
        835                 840                 845             


Tyr Arg Phe 
    850     


<210>  6
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  6

Met His His His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser 
1               5                   10                  15      


Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp 
            20                  25                  30          


Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Ala Glu Ala 
        35                  40                  45              


Val Glu His Phe Ala Asn Gly Val Pro Thr Val Val Gln Asp Val Asn 
    50                  55                  60                  


Val Pro Ala Asp Ser Tyr Phe Gly Gly Ala Asp Ser Ala Val Gly Pro 
65                  70                  75                  80  


Asn Pro Ile Ala Ser Thr His Leu Thr Ile Ser Thr Thr Gln Gly Phe 
                85                  90                  95      


Gly Gln Asn Ala Leu Glu Phe Val Val Gly Gly Ser Leu Ala Asn Gly 
            100                 105                 110         


Asn Gly Asn Pro Ala Asn Ile Asn Gly Asp Ile Val Leu Ile Val Glu 
        115                 120                 125             


Asn Thr Asn Thr Gln Asn Ser Ile Ile Gly Gly Ser Met Ala Asn Ala 
    130                 135                 140                 


Ala Pro Val Thr Ile Gly Gly Ser Ile Phe Met Thr Leu Arg Asn Val 
145                 150                 155                 160 


Thr Ala Val Asp Pro Ile Phe Gly Gly Ser Val Asp Val Arg Phe Phe 
                165                 170                 175     


Ala Gln Gln Gln Pro Asn Glu Asp Gln Leu Val Gly Gly Asp Ile Asn 
            180                 185                 190         


Ile Asn Leu Glu Asn Val Thr Thr Pro Glu Phe Tyr Gly Leu Gly Tyr 
        195                 200                 205             


Ala Asn Gly Val Ile Pro Val Asn Val Leu Asn Arg Asn Phe Leu Val 
    210                 215                 220                 


Ala Val Gln Gly Asn Ile Thr Thr Asn Ile Ser Asn Ser Asn Ile Ala 
225                 230                 235                 240 


Thr Val Met Leu Gly Ser His Tyr Asp Thr Thr Met Ala Val Gly Gly 
                245                 250                 255     


Asn Gly Thr Ile Asn Val Asp Asn Ser Thr Ile Gly Tyr Leu Ser Ala 
            260                 265                 270         


Ser Asn Ser Ser Asp Phe Val Asn Pro Asp Leu Thr Asn Thr Val Thr 
        275                 280                 285             


Phe Asn Ile Gly Pro Asn Asn Arg Ile Ala Asn Ile Phe Ala Ser Asn 
    290                 295                 300                 


Asn Gly Val Ile Pro His Phe Ile Val Asn Met Asp Gly Ser Gly Thr 
305                 310                 315                 320 


Glu Ile Gln Glu Leu Thr Leu Gly Asn Val Ile Arg Gly Gly Leu Val 
                325                 330                 335     


Leu Thr Ser Glu Leu Asn Leu Ser Gln Gly Thr Ile Asn Asn Leu Ile 
            340                 345                 350         


Thr Gly Asn Glu Tyr Tyr Asp Arg Ser Gly Leu Arg Thr Thr Val Asn 
        355                 360                 365             


Val Arg Gly Gly Thr Ile Gly Val Leu Thr Ser Gly Gly Ser Asp Tyr 
    370                 375                 380                 


Ser Glu Leu Asn Phe Ile Pro Gly Glu Ile Ser Thr Ile Leu Ala Thr 
385                 390                 395                 400 


Asn Ser Ile Gly Asn Gln Asp Phe Ala Ser Leu Ser Gln Val Thr Ile 
                405                 410                 415     


His Gln Gly Ala Glu Thr Leu Trp Gly Met Arg Asp Glu Val Phe Glu 
            420                 425                 430         


Leu Gln Thr Asn Asn Leu Gln Leu Gly Gly Glu Leu Phe Ile Pro Ala 
        435                 440                 445             


Asp Gly Thr Gly Gly Val Ala Leu Ile Thr Asn His Ile Ile Ala Asn 
    450                 455                 460                 


Ser Gly Val Ile Thr Pro Val Asn Met Ser Pro Glu Arg Met Thr Pro 
465                 470                 475                 480 


Ile Ile Gly Phe Leu Glu Pro Thr Gly Glu Val Ala Gln Leu Thr Ile 
                485                 490                 495     


Tyr Gly Pro Leu Thr Val Asn Leu Ser His Ser Pro Glu Ile Leu Gly 
            500                 505                 510         


Lys Ile Ile Thr Gln Pro Ile Pro Ile Ala Val Thr Asn Ser Asp Val 
        515                 520                 525             


Phe Gly Thr Ser Lys Leu Phe Val Glu His Asn Thr Lys Gly Leu Ile 
    530                 535                 540                 


Trp Ser Asp Ile Ile Phe Asn Pro Gln Asp Lys Thr Trp Tyr Leu Thr 
545                 550                 555                 560 


Asn Phe Arg Gly Ser Glu Asp Phe Tyr Gly Leu Ser Ala Ala Arg Glu 
                565                 570                 575     


Ala Ser Asn Trp Leu Arg Gln Gln His Ile Trp Ser Leu Gln Arg Arg 
            580                 585                 590         


Ser Asn Lys Leu Leu Asp His Gly Val Asp Gly Leu Trp Met Asn Val 
        595                 600                 605             


Gln Gly Gly Tyr Glu Lys Leu Asp Ala Ala Ile Gly Asp Ala Lys Met 
    610                 615                 620                 


Pro Trp Ile Met Ala Ser Leu Gly Tyr Asp Phe Met His Lys Leu Ser 
625                 630                 635                 640 


Asp Phe Tyr Asn Leu Lys Ala Leu Tyr Gly Phe Gly Phe Gly Phe Ala 
                645                 650                 655     


Thr Gly Lys Asn Lys Trp Asn Thr Ile Asn Ser Thr Thr Asn Asp Ile 
            660                 665                 670         


Tyr Met Gly Leu Val Gly Ala Tyr Val Gly Leu Met His Glu Ala Thr 
        675                 680                 685             


Gly Leu Tyr Gly Thr Val Ser Gly Gln Phe Ala Thr Asn Arg Thr Lys 
    690                 695                 700                 


Thr Lys Cys Thr Gly Phe Asp Glu Thr Tyr Asn Trp Lys Glu Asn Val 
705                 710                 715                 720 


Pro Thr Glu Ala Ile Glu Ile Gly Trp Lys Trp Ser Ile Asp Glu Phe 
                725                 730                 735     


Lys Ile Asn Pro Arg Gly Gln Val Ile Phe Glu Gln Leu Ser Lys His 
            740                 745                 750         


His Phe Ser Leu Ser Gln Glu Gly Asp Thr Ala Ile Leu Asp Lys Glu 
        755                 760                 765             


Phe Leu Thr Thr Thr Val Ile Gly Ile Ser Gly Glu Tyr Asp Leu Asp 
    770                 775                 780                 


Leu Arg Ser Lys Ile Ile Lys Leu Gln Ala Ser Val Asp Trp Ile Lys 
785                 790                 795                 800 


Gly Ile Ser Gly Asp Phe Ala Ala Lys Ser Glu Val Leu Asn Met Lys 
                805                 810                 815     


Phe Lys Asp Lys Asn Asp Thr Ser Thr Phe Arg Gly Thr Leu Gly Ala 
            820                 825                 830         


Ser Ala Gln Leu Leu Glu Asn Phe Glu Val His Leu Asp Ile Phe Gly 
        835                 840                 845             


Asp Leu Gly Asn Asp Lys Gly Ile Gly Gly Gln Val Gly Ala Thr Tyr 
    850                 855                 860                 


Arg Phe 
865     


<210>  7
<211>  1658
<212>  DNA
<213>  Lawsonia intracellularis

<400>  7
atggataaaa ttatacatta taaaactaaa acattagtac attcaatttt ttttcttctt       60

tttttattga cctctcttta tctaacaata cattttgttt atgcacaaaa actaacagag      120

caaaacagtg atgaggacct tagtacagaa caaccagtac atggtggacg tattcgttta      180

ggaacaatag cagaaccaat aaatttaatt ccttacttgt ctacagacgg tacttcacac      240

gaaattgctg acttactatt tgtatctgca cttgagtatg ataaagattt acaagtagta      300

ccactagcag caaagtcata tgaagttttg aatgatggaa aattattacg atttattatg      360

cgtgaagatg tgttttggca agatggagtg caacttactg ttgacgatat agaatttaca      420

tataaattaa tgttagagcc taacacacct acagcttatg cagaggactt tctcactatt      480

aaggagttta aaaaaacagg ccgttttact tttgaagtgt attatgaaaa gccatatgct      540

agagctctaa tgacatggat gggctcaatt ttaccaaaac acattcttga ggggcaagat      600

attaccaaaa caccttttgc tagaaatcct ataggtgctg gaccatataa attaaaaagt      660

tgggaaacag gttctcgcct tattcttgag gcatctgata gttactttaa aggtaagcca      720

tatatctcag aagttattta tacagttatc ccagatagtt caacaatgtt ccttgaatta      780

agagcaggga atttagatat gatgggcctt acaccacaac aatacttaaa gcaaactaaa      840

ggtccacagt gggaaaaaaa ttggaagaaa tatagatatc ttgctttttc atatgcttac      900

ttaggcttta atttaaacaa gcctatgttt caagatatat taactcgtca aggaatttcc      960

catgctattg atcgtcaggc tattgtagat aatgttcttc ttggtgaagg agtcgtttcc     1020

tttggtcctt acaagccagg aacatgggta tacaacacac accttaaacc aatagaatat     1080

aatccagaaa aagctcgaca attatttaca caggcaggat ggaaagatac aggcaatggt     1140

gttcttcaaa gagatggtag gccttttaca tttactatac ttgtgaatca agggaatgaa     1200

caaagagcac gagtagcaag tattattcaa agtcagttaa aagaagtagg aattgaagta     1260

caaattagga ctgtagagtg ggctgctttt cttaaagagt ttatagataa aggaagatat     1320

gatgctgttg ttcttggatg gtctattaca caagatcctg atatttatga tgtatggcat     1380

tcttcaaaag cacatgaagg aggattaaac ttcatggggt ataaaaatac ggaacttgat     1440

gcactccttg tagaagcaag aacagaactt gatcaagcta aacgcaagcc attatatgat     1500

aaaatacaag aaatacttca tcatgatcaa ccatactgtt ttctttttgt accttattct     1560

ttacctatta taaaatctaa atttcatggg ataaaaccag caccagcagg tattatgtat     1620

aatcttgatc agtggtggat tcctaaaaag cttcaata                             1658


<210>  8
<211>  552
<212>  PRT
<213>  Lawsonia intracellularis

<400>  8

Met Asp Lys Ile Ile His Tyr Lys Thr Lys Thr Leu Val His Ser Ile 
1               5                   10                  15      


Phe Phe Leu Leu Phe Leu Leu Thr Ser Leu Tyr Leu Thr Ile His Phe 
            20                  25                  30          


Val Tyr Ala Gln Lys Leu Thr Glu Gln Asn Ser Asp Glu Asp Leu Ser 
        35                  40                  45              


Thr Glu Gln Pro Val His Gly Gly Arg Ile Arg Leu Gly Thr Ile Ala 
    50                  55                  60                  


Glu Pro Ile Asn Leu Ile Pro Tyr Leu Ser Thr Asp Gly Thr Ser His 
65                  70                  75                  80  


Glu Ile Ala Asp Leu Leu Phe Val Ser Ala Leu Glu Tyr Asp Lys Asp 
                85                  90                  95      


Leu Gln Val Val Pro Leu Ala Ala Lys Ser Tyr Glu Val Leu Asn Asp 
            100                 105                 110         


Gly Lys Leu Leu Arg Phe Ile Met Arg Glu Asp Val Phe Trp Gln Asp 
        115                 120                 125             


Gly Val Gln Leu Thr Val Asp Asp Ile Glu Phe Thr Tyr Lys Leu Met 
    130                 135                 140                 


Leu Glu Pro Asn Thr Pro Thr Ala Tyr Ala Glu Asp Phe Leu Thr Ile 
145                 150                 155                 160 


Lys Glu Phe Lys Lys Thr Gly Arg Phe Thr Phe Glu Val Tyr Tyr Glu 
                165                 170                 175     


Lys Pro Tyr Ala Arg Ala Leu Met Thr Trp Met Gly Ser Ile Leu Pro 
            180                 185                 190         


Lys His Ile Leu Glu Gly Gln Asp Ile Thr Lys Thr Pro Phe Ala Arg 
        195                 200                 205             


Asn Pro Ile Gly Ala Gly Pro Tyr Lys Leu Lys Ser Trp Glu Thr Gly 
    210                 215                 220                 


Ser Arg Leu Ile Leu Glu Ala Ser Asp Ser Tyr Phe Lys Gly Lys Pro 
225                 230                 235                 240 


Tyr Ile Ser Glu Val Ile Tyr Thr Val Ile Pro Asp Ser Ser Thr Met 
                245                 250                 255     


Phe Leu Glu Leu Arg Ala Gly Asn Leu Asp Met Met Gly Leu Thr Pro 
            260                 265                 270         


Gln Gln Tyr Leu Lys Gln Thr Lys Gly Pro Gln Trp Glu Lys Asn Trp 
        275                 280                 285             


Lys Lys Tyr Arg Tyr Leu Ala Phe Ser Tyr Ala Tyr Leu Gly Phe Asn 
    290                 295                 300                 


Leu Asn Lys Pro Met Phe Gln Asp Ile Leu Thr Arg Gln Gly Ile Ser 
305                 310                 315                 320 


His Ala Ile Asp Arg Gln Ala Ile Val Asp Asn Val Leu Leu Gly Glu 
                325                 330                 335     


Gly Val Val Ser Phe Gly Pro Tyr Lys Pro Gly Thr Trp Val Tyr Asn 
            340                 345                 350         


Thr His Leu Lys Pro Ile Glu Tyr Asn Pro Glu Lys Ala Arg Gln Leu 
        355                 360                 365             


Phe Thr Gln Ala Gly Trp Lys Asp Thr Gly Asn Gly Val Leu Gln Arg 
    370                 375                 380                 


Asp Gly Arg Pro Phe Thr Phe Thr Ile Leu Val Asn Gln Gly Asn Glu 
385                 390                 395                 400 


Gln Arg Ala Arg Val Ala Ser Ile Ile Gln Ser Gln Leu Lys Glu Val 
                405                 410                 415     


Gly Ile Glu Val Gln Ile Arg Thr Val Glu Trp Ala Ala Phe Leu Lys 
            420                 425                 430         


Glu Phe Ile Asp Lys Gly Arg Tyr Asp Ala Val Val Leu Gly Trp Ser 
        435                 440                 445             


Ile Thr Gln Asp Pro Asp Ile Tyr Asp Val Trp His Ser Ser Lys Ala 
    450                 455                 460                 


His Glu Gly Gly Leu Asn Phe Met Gly Tyr Lys Asn Thr Glu Leu Asp 
465                 470                 475                 480 


Ala Leu Leu Val Glu Ala Arg Thr Glu Leu Asp Gln Ala Lys Arg Lys 
                485                 490                 495     


Pro Leu Tyr Asp Lys Ile Gln Glu Ile Leu His His Asp Gln Pro Tyr 
            500                 505                 510         


Cys Phe Leu Phe Val Pro Tyr Ser Leu Pro Ile Ile Lys Ser Lys Phe 
        515                 520                 525             


His Gly Ile Lys Pro Ala Pro Ala Gly Ile Met Tyr Asn Leu Asp Gln 
    530                 535                 540                 


Trp Trp Ile Pro Lys Lys Leu Gln 
545                 550         


<210>  9
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  9

Met His His His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser 
1               5                   10                  15      


Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp 
            20                  25                  30          


Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Asp Ser Asp 
        35                  40                  45              


Glu Asp Leu Ser Thr Glu Gln Pro Val His Gly Gly Arg Ile Arg Leu 
    50                  55                  60                  


Gly Thr Ile Ala Glu Pro Ile Asn Leu Ile Pro Tyr Leu Ser Thr Asp 
65                  70                  75                  80  


Gly Thr Ser His Glu Ile Ala Asp Leu Leu Phe Val Ser Ala Leu Glu 
                85                  90                  95      


Tyr Asp Lys Asp Leu Gln Val Val Pro Leu Ala Ala Lys Ser Tyr Glu 
            100                 105                 110         


Val Leu Asn Asp Gly Lys Leu Leu Arg Phe Ile Met Arg Glu Asp Val 
        115                 120                 125             


Phe Trp Gln Asp Gly Val Gln Leu Thr Val Asp Asp Ile Glu Phe Thr 
    130                 135                 140                 


Tyr Lys Leu Met Leu Glu Pro Asn Thr Pro Thr Ala Tyr Ala Glu Asp 
145                 150                 155                 160 


Phe Leu Thr Ile Lys Glu Phe Lys Lys Thr Gly Arg Phe Thr Phe Glu 
                165                 170                 175     


Val Tyr Tyr Glu Lys Pro Tyr Ala Arg Ala Leu Met Thr Trp Met Gly 
            180                 185                 190         


Ser Ile Leu Pro Lys His Ile Leu Glu Gly Gln Asp Ile Thr Lys Thr 
        195                 200                 205             


Pro Phe Ala Arg Asn Pro Ile Gly Ala Gly Pro Tyr Lys Leu Lys Ser 
    210                 215                 220                 


Trp Glu Thr Gly Ser Arg Leu Ile Leu Glu Ala Ser Asp Ser Tyr Phe 
225                 230                 235                 240 


Lys Gly Lys Pro Tyr Ile Ser Glu Val Ile Tyr Thr Val Ile Pro Asp 
                245                 250                 255     


Ser Ser Thr Met Phe Leu Glu Leu Arg Ala Gly Asn Leu Asp Met Met 
            260                 265                 270         


Gly Leu Thr Pro Gln Gln Tyr Leu Lys Gln Thr Lys Gly Pro Gln Trp 
        275                 280                 285             


Glu Lys Asn Trp Lys Lys Tyr Arg Tyr Leu Ala Phe Ser Tyr Ala Tyr 
    290                 295                 300                 


Leu Gly Phe Asn Leu Asn Lys Pro Met Phe Gln Asp Ile Leu Thr Arg 
305                 310                 315                 320 


Gln Gly Ile Ser His Ala Ile Asp Arg Gln Ala Ile Val Asp Asn Val 
                325                 330                 335     


Leu Leu Gly Glu Gly Val Val Ser Phe Gly Pro Tyr Lys Pro Gly Thr 
            340                 345                 350         


Trp Val Tyr Asn Thr His Leu Lys Pro Ile Glu Tyr Asn Pro Glu Lys 
        355                 360                 365             


Ala Arg Gln Leu Phe Thr Gln Ala Gly Trp Lys Asp Thr Gly Asn Gly 
    370                 375                 380                 


Val Leu Gln Arg Asp Gly Arg Pro Phe Thr Phe Thr Ile Leu Val Asn 
385                 390                 395                 400 


Gln Gly Asn Glu Gln Arg Ala Arg Val Ala Ser Ile Ile Gln Ser Gln 
                405                 410                 415     


Leu Lys Glu Val Gly Ile Glu Val Gln Ile Arg Thr Val Glu Trp Ala 
            420                 425                 430         


Ala Phe Leu Lys Glu Phe Ile Asp Lys Gly Arg Tyr Asp Ala Val Val 
        435                 440                 445             


Leu Gly Trp Ser Ile Thr Gln Asp Pro Asp Ile Tyr Asp Val Trp His 
    450                 455                 460                 


Ser Ser Lys Ala His Glu Gly Gly Leu Asn Phe Met Gly Tyr Lys Asn 
465                 470                 475                 480 


Thr Glu Leu Asp Ala Leu Leu Val Glu Ala Arg Thr Glu Leu Asp Gln 
                485                 490                 495     


Ala Lys Arg Lys Pro Leu Tyr Asp Lys Ile Gln Glu Ile Leu His His 
            500                 505                 510         


Asp Gln Pro Tyr Cys Phe Leu Phe Val Pro Tyr Ser Leu Pro Ile Ile 
        515                 520                 525             


Lys Ser Lys Phe His Gly Ile Lys Pro Ala Pro Ala Gly Ile Met Tyr 
    530                 535                 540                 


Asn Leu Asp Gln Trp Trp Ile Pro Thr Arg Ala Pro Pro Pro Pro Pro 
545                 550                 555                 560 


Leu Arg Ser Gly Cys 
                565 


<210>  10
<211>  1197
<212>  DNA
<213>  Lawsonia intracellularis

<400>  10
gagatagtta tggctaatgt tagtggaatc cctgcaccac gattactttc cacaacaaat       60

caaatgacca atgcagctgc tggtaatact aatagagcta ccggtagtat gaacggtcgt      120

aatctcacac aaataaaaac acctcagtcc atgattgata atgcttcaga agaattaaca      180

acttctcttg aatctaaaag cagtgacgac tttgcaatta aagatcgtaa aagacaaggg      240

aaaggatctg attctctatt aaaaatggtt caagaatata cagagctgac gaatgatgat      300

acccgtaatg ctaaaagagc tatgttatcc caggtattac gtgcaagtca aagttcacaa      360

gatgtactcg aaaaaacatt agaacaattt tctaataaaa cagatgcttg ggcttctctt      420

gcagaaattg cacaagaata tggtgcagaa tctccacagc caacaggatt aaaatctgta      480

ttagatgcta tggagacatt agaaaatgag tttggtgatg aaattaaagc aggactaaaa      540

ggagctctaa attcaaaaga atttactgat ataggcagtg cagcacagtt aagagatctt      600

tatacaacaa cagtaactat aacagctgca cctgatgcag tgttagcaag acttcttgaa      660

gaatatgaga gtgatgatga tctggataga gccattgatt tccttctatc tacacttggt      720

ggagagcttg aatcagctga tccaagtatg gataaagtac atcttcaaag tgtaatgggt      780

gatattgaaa aaacacaaca acttcatagc tctcataaac aatgtactac agcccttagc      840

aggtggaaag agaaacataa aggtgggggg gaaaatagta cactaactcc tttagaaatg      900

atgcgtgaac taattgcact aaaaaatgaa aattttattt ctccttcctc tatagataaa      960

attgttgatc aagctgatcc ccaagatatt gaaaaagaag tccttttttt acaagagatg     1020

ttagctgctg taagaaaatt tcccattatg gtatttgata atgtcgaaaa tcgtgtaaga     1080

gttatgggtg ctgtacaaga tgctgttgac gatgctgtaa gaagagaaga tgaattcctc     1140

tttcaaaaag aacatcctga tgtaccacta caaccagatg aaaataatat acaataa        1197


<210>  11
<211>  398
<212>  PRT
<213>  Lawsonia intracellularis

<400>  11

Glu Ile Val Met Ala Asn Val Ser Gly Ile Pro Ala Pro Arg Leu Leu 
1               5                   10                  15      


Ser Thr Thr Asn Gln Met Thr Asn Ala Ala Ala Gly Asn Thr Asn Arg 
            20                  25                  30          


Ala Thr Gly Ser Met Asn Gly Arg Asn Leu Thr Gln Ile Lys Thr Pro 
        35                  40                  45              


Gln Ser Met Ile Asp Asn Ala Ser Glu Glu Leu Thr Thr Ser Leu Glu 
    50                  55                  60                  


Ser Lys Ser Ser Asp Asp Phe Ala Ile Lys Asp Arg Lys Arg Gln Gly 
65                  70                  75                  80  


Lys Gly Ser Asp Ser Leu Leu Lys Met Val Gln Glu Tyr Thr Glu Leu 
                85                  90                  95      


Thr Asn Asp Asp Thr Arg Asn Ala Lys Arg Ala Met Leu Ser Gln Val 
            100                 105                 110         


Leu Arg Ala Ser Gln Ser Ser Gln Asp Val Leu Glu Lys Thr Leu Glu 
        115                 120                 125             


Gln Phe Ser Asn Lys Thr Asp Ala Trp Ala Ser Leu Ala Glu Ile Ala 
    130                 135                 140                 


Gln Glu Tyr Gly Ala Glu Ser Pro Gln Pro Thr Gly Leu Lys Ser Val 
145                 150                 155                 160 


Leu Asp Ala Met Glu Thr Leu Glu Asn Glu Phe Gly Asp Glu Ile Lys 
                165                 170                 175     


Ala Gly Leu Lys Gly Ala Leu Asn Ser Lys Glu Phe Thr Asp Ile Gly 
            180                 185                 190         


Ser Ala Ala Gln Leu Arg Asp Leu Tyr Thr Thr Thr Val Thr Ile Thr 
        195                 200                 205             


Ala Ala Pro Asp Ala Val Leu Ala Arg Leu Leu Glu Glu Tyr Glu Ser 
    210                 215                 220                 


Asp Asp Asp Leu Asp Arg Ala Ile Asp Phe Leu Leu Ser Thr Leu Gly 
225                 230                 235                 240 


Gly Glu Leu Glu Ser Ala Asp Pro Ser Met Asp Lys Val His Leu Gln 
                245                 250                 255     


Ser Val Met Gly Asp Ile Glu Lys Thr Gln Gln Leu His Ser Ser His 
            260                 265                 270         


Lys Gln Cys Thr Thr Ala Leu Ser Arg Trp Lys Glu Lys His Lys Gly 
        275                 280                 285             


Gly Gly Glu Asn Ser Thr Leu Thr Pro Leu Glu Met Met Arg Glu Leu 
    290                 295                 300                 


Ile Ala Leu Lys Asn Glu Asn Phe Ile Ser Pro Ser Ser Ile Asp Lys 
305                 310                 315                 320 


Ile Val Asp Gln Ala Asp Pro Gln Asp Ile Glu Lys Glu Val Leu Phe 
                325                 330                 335     


Leu Gln Glu Met Leu Ala Ala Val Arg Lys Phe Pro Ile Met Val Phe 
            340                 345                 350         


Asp Asn Val Glu Asn Arg Val Arg Val Met Gly Ala Val Gln Asp Ala 
        355                 360                 365             


Val Asp Asp Ala Val Arg Arg Glu Asp Glu Phe Leu Phe Gln Lys Glu 
    370                 375                 380                 


His Pro Asp Val Pro Leu Gln Pro Asp Glu Asn Asn Ile Gln 
385                 390                 395             


<210>  12
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  12

Met His His His His His His Gly Ser Ala Asn Val Ser Gly Ile Pro 
1               5                   10                  15      


Ala Pro Arg Leu Leu Ser Thr Thr Asn Gln Met Thr Asn Ala Ala Ala 
            20                  25                  30          


Gly Asn Thr Asn Arg Ala Thr Gly Ser Met Asn Gly Arg Asn Leu Thr 
        35                  40                  45              


Gln Ile Lys Thr Pro Gln Ser Met Ile Asp Asn Ala Ser Glu Glu Leu 
    50                  55                  60                  


Thr Thr Ser Leu Glu Ser Lys Ser Ser Asp Asp Phe Ala Ile Lys Asp 
65                  70                  75                  80  


Arg Lys Arg Gln Gly Lys Gly Ser Asp Ser Leu Leu Lys Met Val Gln 
                85                  90                  95      


Glu Tyr Thr Glu Leu Thr Asn Asp Asp Thr Arg Asn Ala Lys Arg Ala 
            100                 105                 110         


Met Leu Ser Gln Val Leu Arg Ala Ser Gln Ser Ser Gln Asp Val Leu 
        115                 120                 125             


Glu Lys Thr Leu Glu Gln Phe Ser Asn Lys Thr Asp Ala Trp Ala Ser 
    130                 135                 140                 


Leu Ala Glu Ile Ala Gln Glu Tyr Gly Ala Glu Ser Pro Gln Pro Thr 
145                 150                 155                 160 


Gly Leu Lys Ser Val Leu Asp Ala Met Glu Thr Leu Glu Asn Glu Phe 
                165                 170                 175     


Gly Asp Glu Ile Lys Ala Gly Leu Lys Gly Ala Leu Asn Ser Lys Glu 
            180                 185                 190         


Phe Thr Asp Ile Gly Ser Ala Ala Gln Leu Arg Asp Leu Tyr Thr Thr 
        195                 200                 205             


Thr Val Thr Ile Thr Ala Ala Pro Asp Ala Val Leu Ala Arg Leu Leu 
    210                 215                 220                 


Glu Glu Tyr Glu Ser Asp Asp Asp Leu Asp Arg Ala Ile Asp Phe Leu 
225                 230                 235                 240 


Leu Ser Thr Leu Gly Gly Glu Leu Glu Ser Ala Asp Pro Ser Met Asp 
                245                 250                 255     


Lys Val His Leu Gln Ser Val Met Gly Asp Ile Glu Lys Thr Gln Gln 
            260                 265                 270         


Leu His Ser Ser His Lys Gln Cys Thr Thr Ala Leu Ser Arg Trp Lys 
        275                 280                 285             


Glu Lys His Lys Gly Gly Gly Glu Asn Ser Thr Leu Thr Pro Leu Glu 
    290                 295                 300                 


Met Met Arg Glu Leu Ile Ala Leu Lys Asn Glu Asn Phe Ile Ser Pro 
305                 310                 315                 320 


Ser Ser Ile Asp Lys Ile Val Asp Gln Ala Asp Pro Gln Asp Ile Glu 
                325                 330                 335     


Lys Glu Val Leu Phe Leu Gln Glu Met Leu Ala Ala Val Arg Lys Phe 
            340                 345                 350         


Pro Ile Met Val Phe Asp Asn Val Glu Asn Arg Val Arg Val Met Gly 
        355                 360                 365             


Ala Val Gln Asp Ala Val Asp Asp Ala Val Arg Arg Glu Asp Glu Phe 
    370                 375                 380                 


Leu Phe Gln Lys Glu His Pro Asp Val Pro Leu Gln Pro Asp Glu Asn 
385                 390                 395                 400 


Asn Ile Gln 
            


<210>  13
<211>  1152
<212>  DNA
<213>  Lawsonia intracellularis

<400>  13
atgttgttat atataaataa agaacacatt attgatggtc ttcaaaaagt tgcaaatatt       60

attcctgcac gctcaggtgc tgcatattta cgtacacttt ggatgaaagc agaacattca      120

acgctgacaa taatggctac agatgcaaat attgaattta tagggaatta tgaagctgat      180

ataaaagaaa ctggacttgt aggagtaaat ggaagaaatt taattgatct tattcgtaga      240

ttacctgcaa aagaactttg tctacgtttt gattcaacat caggaacact tattcttgaa      300

caagaacgtc gtacatataa aatgcctatt aatgacccta tttggtttca acctttaact      360

ttattccctt cagaagaaag tgtagtatgg tcagctgact tttttcaaga agtcattgat      420

cgagtatcat tttgtattag tgatgatgaa ggttctgatg ctatttcatg tctttatatt      480

caaccttcta atgataacta tataaatgta tgtggtttaa atggacatca atttgcttta      540

acacggttta taaataatga gttaagtgaa aaaattccta gtgaaggaat acttattcct      600

aaaaaatata taacagaact tcgtaaatgg ttaggagaaa cagaaataga aatagctata      660

acagaaaaac gattttttgc acgaacaata gatagtaaag aaacaataag tgtcccaagg      720

gcgatattta cctatcctga ttatacagct tttctcactc gactaacagg agacaatatg      780

tcttttctta aacttcaaag aaaagattgt cttgagtcac ttgatcgaat atctattttt      840

aatactgaag gtgatagatg tacctatttt gatataaagg aaaatgaact cattctatct      900

gcacaagggc aagacacagg atctgccaat gaatacctag atgttactta tacaggtaat      960

ataaataaaa tagcatttcc gactaaaagt cttatggaaa tatttaatca ctttgaatca     1020

cctactatca ctttagcaat gtcaagtgtt gaagggccat gtggaataac aggtgatgaa     1080

gataaagatt atactgtaat tattatgcct atgaaaattg ttgaacaaaa ttattataca     1140

gaagaagtat aa                                                         1152


<210>  14
<211>  383
<212>  PRT
<213>  Lawsonia intracellularis

<400>  14

Met Leu Leu Tyr Ile Asn Lys Glu His Ile Ile Asp Gly Leu Gln Lys 
1               5                   10                  15      


Val Ala Asn Ile Ile Pro Ala Arg Ser Gly Ala Ala Tyr Leu Arg Thr 
            20                  25                  30          


Leu Trp Met Lys Ala Glu His Ser Thr Leu Thr Ile Met Ala Thr Asp 
        35                  40                  45              


Ala Asn Ile Glu Phe Ile Gly Asn Tyr Glu Ala Asp Ile Lys Glu Thr 
    50                  55                  60                  


Gly Leu Val Gly Val Asn Gly Arg Asn Leu Ile Asp Leu Ile Arg Arg 
65                  70                  75                  80  


Leu Pro Ala Lys Glu Leu Cys Leu Arg Phe Asp Ser Thr Ser Gly Thr 
                85                  90                  95      


Leu Ile Leu Glu Gln Glu Arg Arg Thr Tyr Lys Met Pro Ile Asn Asp 
            100                 105                 110         


Pro Ile Trp Phe Gln Pro Leu Thr Leu Phe Pro Ser Glu Glu Ser Val 
        115                 120                 125             


Val Trp Ser Ala Asp Phe Phe Gln Glu Val Ile Asp Arg Val Ser Phe 
    130                 135                 140                 


Cys Ile Ser Asp Asp Glu Gly Ser Asp Ala Ile Ser Cys Leu Tyr Ile 
145                 150                 155                 160 


Gln Pro Ser Asn Asp Asn Tyr Ile Asn Val Cys Gly Leu Asn Gly His 
                165                 170                 175     


Gln Phe Ala Leu Thr Arg Phe Ile Asn Asn Glu Leu Ser Glu Lys Ile 
            180                 185                 190         


Pro Ser Glu Gly Ile Leu Ile Pro Lys Lys Tyr Ile Thr Glu Leu Arg 
        195                 200                 205             


Lys Trp Leu Gly Glu Thr Glu Ile Glu Ile Ala Ile Thr Glu Lys Arg 
    210                 215                 220                 


Phe Phe Ala Arg Thr Ile Asp Ser Lys Glu Thr Ile Ser Val Pro Arg 
225                 230                 235                 240 


Ala Ile Phe Thr Tyr Pro Asp Tyr Thr Ala Phe Leu Thr Arg Leu Thr 
                245                 250                 255     


Gly Asp Asn Met Ser Phe Leu Lys Leu Gln Arg Lys Asp Cys Leu Glu 
            260                 265                 270         


Ser Leu Asp Arg Ile Ser Ile Phe Asn Thr Glu Gly Asp Arg Cys Thr 
        275                 280                 285             


Tyr Phe Asp Ile Lys Glu Asn Glu Leu Ile Leu Ser Ala Gln Gly Gln 
    290                 295                 300                 


Asp Thr Gly Ser Ala Asn Glu Tyr Leu Asp Val Thr Tyr Thr Gly Asn 
305                 310                 315                 320 


Ile Asn Lys Ile Ala Phe Pro Thr Lys Ser Leu Met Glu Ile Phe Asn 
                325                 330                 335     


His Phe Glu Ser Pro Thr Ile Thr Leu Ala Met Ser Ser Val Glu Gly 
            340                 345                 350         


Pro Cys Gly Ile Thr Gly Asp Glu Asp Lys Asp Tyr Thr Val Ile Ile 
        355                 360                 365             


Met Pro Met Lys Ile Val Glu Gln Asn Tyr Tyr Thr Glu Glu Val 
    370                 375                 380             


<210>  15
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  15

Met His His His His His His Gly Ser Met Leu Leu Tyr Ile Asn Lys 
1               5                   10                  15      


Glu His Ile Ile Asp Gly Leu Gln Lys Val Ala Asn Ile Ile Pro Ala 
            20                  25                  30          


Arg Ser Gly Ala Ala Tyr Leu Arg Thr Leu Trp Met Lys Ala Glu His 
        35                  40                  45              


Ser Thr Leu Thr Ile Met Ala Thr Asp Ala Asn Ile Glu Phe Ile Gly 
    50                  55                  60                  


Asn Tyr Glu Ala Asp Ile Lys Glu Thr Gly Leu Val Gly Val Asn Gly 
65                  70                  75                  80  


Arg Asn Leu Ile Asp Leu Ile Arg Arg Leu Pro Ala Lys Glu Leu Cys 
                85                  90                  95      


Leu Arg Phe Asp Ser Thr Ser Gly Thr Leu Ile Leu Glu Gln Glu Arg 
            100                 105                 110         


Arg Thr Tyr Lys Met Pro Ile Asn Asp Pro Ile Trp Phe Gln Pro Leu 
        115                 120                 125             


Thr Leu Phe Pro Ser Glu Glu Ser Val Val Trp Ser Ala Asp Phe Phe 
    130                 135                 140                 


Gln Glu Val Ile Asp Arg Val Ser Phe Cys Ile Ser Asp Asp Glu Gly 
145                 150                 155                 160 


Ser Asp Ala Ile Ser Cys Leu Tyr Ile Gln Pro Ser Asn Asp Asn Tyr 
                165                 170                 175     


Ile Asn Val Cys Gly Leu Asn Gly His Gln Phe Ala Leu Thr Arg Phe 
            180                 185                 190         


Ile Asn Asn Glu Leu Ser Glu Lys Ile Pro Ser Glu Gly Ile Leu Ile 
        195                 200                 205             


Pro Lys Lys Tyr Ile Thr Glu Leu Arg Lys Trp Leu Gly Glu Thr Glu 
    210                 215                 220                 


Ile Glu Ile Ala Ile Thr Glu Lys Arg Phe Phe Ala Arg Thr Ile Asp 
225                 230                 235                 240 


Ser Lys Glu Thr Ile Ser Val Pro Arg Ala Ile Phe Thr Tyr Pro Asp 
                245                 250                 255     


Tyr Thr Ala Phe Leu Thr Arg Leu Thr Gly Asp Asn Met Ser Phe Leu 
            260                 265                 270         


Lys Leu Gln Arg Lys Asp Cys Leu Glu Ser Leu Asp Arg Ile Ser Ile 
        275                 280                 285             


Phe Asn Thr Glu Gly Asp Arg Cys Thr Tyr Phe Asp Ile Lys Glu Asn 
    290                 295                 300                 


Glu Leu Ile Leu Ser Ala Gln Gly Gln Asp Thr Gly Ser Ala Asn Glu 
305                 310                 315                 320 


Tyr Leu Asp Val Thr Tyr Thr Gly Asn Ile Asn Lys Ile Ala Phe Pro 
                325                 330                 335     


Thr Lys Ser Leu Met Glu Ile Phe Asn His Phe Glu Ser Pro Thr Ile 
            340                 345                 350         


Thr Leu Ala Met Ser Ser Val Glu Gly Pro Cys Gly Ile Thr Gly Asp 
        355                 360                 365             


Glu Asp Lys Asp Tyr Thr Val Ile Ile Met Pro Met Lys Ile Val Glu 
    370                 375                 380                 


Gln Asn Tyr Tyr Thr Glu Glu Val 
385                 390         


<210>  16
<211>  1689
<212>  DNA
<213>  Lawsonia intracellularis

<400>  16
atgttcaaaa aaatatatgt tttttatatc acacttcttc ttatattttt aacatatgtt       60

acaccttatg atgtatggag ctttgatctt actattcttc atacaaatga tatacattct      120

caccttggag gaattaaaaa agaatcaggt aatccttgct tcacatctac tacaccagat      180

tgcgtaggtg gaatggcacg tttagcacaa tctattttag acattcgtca atcaacacca      240

aatactattc ttcttgatgc aggagatcaa tttgtaggaa cagcttttca ttctgacttt      300

ataaatacac cagatcaact cccatttgta aagtttttaa atagacttgg atatgtagct      360

atgtcaccag gaaatcatga gtttgatcat ggatgttatg aattttttag tgctataaga      420

caacttaact ttcctgttgt agttgcaaac ctcaccttta cagatcctga aatgcaatca      480

tcaattactc catggaccat tgtagaacgt gaaggaaaac gtattggtat cataggactt      540

attacagaag caacagccac tggatcaaga gcatgctctc aagccatttt tactaatgct      600

gaacaagcat tacgtaatgc aattcaagaa ataaaaaaac aaaatgtatt tacaattatt      660

gtgttaagcc atcttggaat aaatgtagat atggaacttg ctagtaaagt cgatgatgtc      720

tctgtttttg taggaggtca tacacatact ttgctttcta acacctaccc taatgcttat      780

gggccttatc ctatagtaaa acattcacct tctggacatc ctgtacttat tgtaacagca      840

aaagaaaaac tagaatatct tggaaggatt aatataacat ttgatgaaca aggtatccct      900

caaaaatgga atggagatgt tatacgtctt gataagccaa ttagtaatga tcctgctata      960

gtatccatag cagaactgct tgatagctat ggtataccta ttaaagaaaa gcttgaagta     1020

aaagttggag aaatagctca tcctagaaat ccaaattttg atacatccca accttcaaat     1080

gaacaactag acgaaaaacc tttcttttac tgtagaaaac aagagggatt aacagctaat     1140

attattcttg atgcaatatt agaagcaggc cgctcaaatg gagcacaaat agcaattgta     1200

accactggat taataagagg aaatttacct atagggcttg tacaaaaact tgatgttgtt     1260

acagctatac ctattgaaga taaactttat gtaggagatg ttacaggaaa aataattcag     1320

gaagctatag aaaatggagt ctcaaaagta cattgctttg cctttgcagg aacttttctt     1380

caagttgcag gactcagatt cactttaaat gctgaaaaac ctgtaggtga acgcattcaa     1440

tctattgaat atttaaataa tgggaaatat gagccactgg accctaataa aacatatcgt     1500

gttataatta atggatatcc tactgaggga catgatggat ttataatgtt aaaagacata     1560

aaatggacag atatccaaaa aagtccagta gaagctgtta taagctatct aaaagaacat     1620

tctcctctca atgtaaaaaa agatggacgt attgttaatg taacacctat tattgtccct     1680

aatgaataa                                                             1689


<210>  17
<211>  562
<212>  PRT
<213>  Lawsonia intracellularis

<400>  17

Met Phe Lys Lys Ile Tyr Val Phe Tyr Ile Thr Leu Leu Leu Ile Phe 
1               5                   10                  15      


Leu Thr Tyr Val Thr Pro Tyr Asp Val Trp Ser Phe Asp Leu Thr Ile 
            20                  25                  30          


Leu His Thr Asn Asp Ile His Ser His Leu Gly Gly Ile Lys Lys Glu 
        35                  40                  45              


Ser Gly Asn Pro Cys Phe Thr Ser Thr Thr Pro Asp Cys Val Gly Gly 
    50                  55                  60                  


Met Ala Arg Leu Ala Gln Ser Ile Leu Asp Ile Arg Gln Ser Thr Pro 
65                  70                  75                  80  


Asn Thr Ile Leu Leu Asp Ala Gly Asp Gln Phe Val Gly Thr Ala Phe 
                85                  90                  95      


His Ser Asp Phe Ile Asn Thr Pro Asp Gln Leu Pro Phe Val Lys Phe 
            100                 105                 110         


Leu Asn Arg Leu Gly Tyr Val Ala Met Ser Pro Gly Asn His Glu Phe 
        115                 120                 125             


Asp His Gly Cys Tyr Glu Phe Phe Ser Ala Ile Arg Gln Leu Asn Phe 
    130                 135                 140                 


Pro Val Val Val Ala Asn Leu Thr Phe Thr Asp Pro Glu Met Gln Ser 
145                 150                 155                 160 


Ser Ile Thr Pro Trp Thr Ile Val Glu Arg Glu Gly Lys Arg Ile Gly 
                165                 170                 175     


Ile Ile Gly Leu Ile Thr Glu Ala Thr Ala Thr Gly Ser Arg Ala Cys 
            180                 185                 190         


Ser Gln Ala Ile Phe Thr Asn Ala Glu Gln Ala Leu Arg Asn Ala Ile 
        195                 200                 205             


Gln Glu Ile Lys Lys Gln Asn Val Phe Thr Ile Ile Val Leu Ser His 
    210                 215                 220                 


Leu Gly Ile Asn Val Asp Met Glu Leu Ala Ser Lys Val Asp Asp Val 
225                 230                 235                 240 


Ser Val Phe Val Gly Gly His Thr His Thr Leu Leu Ser Asn Thr Tyr 
                245                 250                 255     


Pro Asn Ala Tyr Gly Pro Tyr Pro Ile Val Lys His Ser Pro Ser Gly 
            260                 265                 270         


His Pro Val Leu Ile Val Thr Ala Lys Glu Lys Leu Glu Tyr Leu Gly 
        275                 280                 285             


Arg Ile Asn Ile Thr Phe Asp Glu Gln Gly Ile Pro Gln Lys Trp Asn 
    290                 295                 300                 


Gly Asp Val Ile Arg Leu Asp Lys Pro Ile Ser Asn Asp Pro Ala Ile 
305                 310                 315                 320 


Val Ser Ile Ala Glu Leu Leu Asp Ser Tyr Gly Ile Pro Ile Lys Glu 
                325                 330                 335     


Lys Leu Glu Val Lys Val Gly Glu Ile Ala His Pro Arg Asn Pro Asn 
            340                 345                 350         


Phe Asp Thr Ser Gln Pro Ser Asn Glu Gln Leu Asp Glu Lys Pro Phe 
        355                 360                 365             


Phe Tyr Cys Arg Lys Gln Glu Gly Leu Thr Ala Asn Ile Ile Leu Asp 
    370                 375                 380                 


Ala Ile Leu Glu Ala Gly Arg Ser Asn Gly Ala Gln Ile Ala Ile Val 
385                 390                 395                 400 


Thr Thr Gly Leu Ile Arg Gly Asn Leu Pro Ile Gly Leu Val Gln Lys 
                405                 410                 415     


Leu Asp Val Val Thr Ala Ile Pro Ile Glu Asp Lys Leu Tyr Val Gly 
            420                 425                 430         


Asp Val Thr Gly Lys Ile Ile Gln Glu Ala Ile Glu Asn Gly Val Ser 
        435                 440                 445             


Lys Val His Cys Phe Ala Phe Ala Gly Thr Phe Leu Gln Val Ala Gly 
    450                 455                 460                 


Leu Arg Phe Thr Leu Asn Ala Glu Lys Pro Val Gly Glu Arg Ile Gln 
465                 470                 475                 480 


Ser Ile Glu Tyr Leu Asn Asn Gly Lys Tyr Glu Pro Leu Asp Pro Asn 
                485                 490                 495     


Lys Thr Tyr Arg Val Ile Ile Asn Gly Tyr Pro Thr Glu Gly His Asp 
            500                 505                 510         


Gly Phe Ile Met Leu Lys Asp Ile Lys Trp Thr Asp Ile Gln Lys Ser 
        515                 520                 525             


Pro Val Glu Ala Val Ile Ser Tyr Leu Lys Glu His Ser Pro Leu Asn 
    530                 535                 540                 


Val Lys Lys Asp Gly Arg Ile Val Asn Val Thr Pro Ile Ile Val Pro 
545                 550                 555                 560 


Asn Glu 
        


<210>  18
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  18

Met His His His His His His Gly Ser Met Phe Lys Lys Ile Tyr Val 
1               5                   10                  15      


Phe Tyr Ile Thr Leu Leu Leu Ile Phe Leu Thr Tyr Val Thr Pro Tyr 
            20                  25                  30          


Asp Val Trp Ser Phe Asp Leu Thr Ile Leu His Thr Asn Asp Ile His 
        35                  40                  45              


Ser His Leu Gly Gly Ile Lys Lys Glu Ser Gly Asn Pro Cys Phe Thr 
    50                  55                  60                  


Ser Thr Thr Pro Asp Cys Val Gly Gly Met Ala Arg Leu Ala Gln Ser 
65                  70                  75                  80  


Ile Leu Asp Ile Arg Gln Ser Thr Pro Asn Thr Ile Leu Leu Asp Ala 
                85                  90                  95      


Gly Asp Gln Phe Val Gly Thr Ala Phe His Ser Asp Phe Ile Asn Thr 
            100                 105                 110         


Pro Asp Gln Leu Pro Phe Val Lys Phe Leu Asn Arg Leu Gly Tyr Val 
        115                 120                 125             


Ala Met Ser Pro Gly Asn His Glu Phe Asp His Gly Cys Tyr Glu Phe 
    130                 135                 140                 


Phe Ser Ala Ile Arg Gln Leu Asn Phe Pro Val Val Val Ala Asn Leu 
145                 150                 155                 160 


Thr Phe Thr Asp Pro Glu Met Gln Ser Ser Ile Thr Pro Trp Thr Ile 
                165                 170                 175     


Val Glu Arg Glu Gly Lys Arg Ile Gly Ile Ile Gly Leu Ile Thr Glu 
            180                 185                 190         


Ala Thr Ala Thr Gly Ser Arg Ala Cys Ser Gln Ala Ile Phe Thr Asn 
        195                 200                 205             


Ala Glu Gln Ala Leu Arg Asn Ala Ile Gln Glu Ile Lys Lys Gln Asn 
    210                 215                 220                 


Val Phe Thr Ile Ile Val Leu Ser His Leu Gly Ile Asn Val Asp Met 
225                 230                 235                 240 


Glu Leu Ala Ser Lys Val Asp Asp Val Ser Val Phe Val Gly Gly His 
                245                 250                 255     


Thr His Thr Leu Leu Ser Asn Thr Tyr Pro Asn Ala Tyr Gly Pro Tyr 
            260                 265                 270         


Pro Ile Val Lys His Ser Pro Ser Gly His Pro Val Leu Ile Val Thr 
        275                 280                 285             


Ala Lys Glu Lys Leu Glu Tyr Leu Gly Arg Ile Asn Ile Thr Phe Asp 
    290                 295                 300                 


Glu Gln Gly Ile Pro Gln Lys Trp Asn Gly Asp Val Ile Arg Leu Asp 
305                 310                 315                 320 


Lys Pro Ile Ser Asn Asp Pro Ala Ile Val Ser Ile Ala Glu Leu Leu 
                325                 330                 335     


Asp Ser Tyr Gly Ile Pro Ile Lys Glu Lys Leu Glu Val Lys Val Gly 
            340                 345                 350         


Glu Ile Ala His Pro Arg Asn Pro Asn Phe Asp Thr Ser Gln Pro Ser 
        355                 360                 365             


Asn Glu Gln Leu Asp Glu Lys Pro Phe Phe Tyr Cys Arg Lys Gln Glu 
    370                 375                 380                 


Gly Leu Thr Ala Asn Ile Ile Leu Asp Ala Ile Leu Glu Ala Gly Arg 
385                 390                 395                 400 


Ser Asn Gly Ala Gln Ile Ala Ile Val Thr Thr Gly Leu Ile Arg Gly 
                405                 410                 415     


Asn Leu Pro Ile Gly Leu Val Gln Lys Leu Asp Val Val Thr Ala Ile 
            420                 425                 430         


Pro Ile Glu Asp Lys Leu Tyr Val Gly Asp Val Thr Gly Lys Ile Ile 
        435                 440                 445             


Gln Glu Ala Ile Glu Asn Gly Val Ser Lys Val His Cys Phe Ala Phe 
    450                 455                 460                 


Ala Gly Thr Phe Leu Gln Val Ala Gly Leu Arg Phe Thr Leu Asn Ala 
465                 470                 475                 480 


Glu Lys Pro Val Gly Glu Arg Ile Gln Ser Ile Glu Tyr Leu Asn Asn 
                485                 490                 495     


Gly Lys Tyr Glu Pro Leu Asp Pro Asn Lys Thr Tyr Arg Val Ile Ile 
            500                 505                 510         


Asn Gly Tyr Pro Thr Glu Gly His Asp Gly Phe Ile Met Leu Lys Asp 
        515                 520                 525             


Ile Lys Trp Thr Asp Ile Gln Lys Ser Pro Val Glu Ala Val Ile Ser 
    530                 535                 540                 


Tyr Leu Lys Glu His Ser Pro Leu Asn Val Lys Lys Asp Gly Arg Ile 
545                 550                 555                 560 


Val Asn Val Thr Pro Ile Ile Val Pro Asn Glu 
                565                 570     


<210>  19
<211>  1458
<212>  DNA
<213>  Lawsonia intracellularis

<400>  19
atgcatctat ataatactat ggaaaagaaa aaagagccac ttatacctat aatttcagga       60

aagttaggta tatatgtttg tggaattaca gcgtatgatt tttctcatat tggacatgca      120

cgatctgcca tagtttttga tatcttggtg agattattac gatatcaagg atatgatgta      180

acatttatac gtaattttac agatattgat gataaaatta ttaatcgtgc taataaagag      240

ggccgtagta gtaaagaggt tgcagaagaa tttataaatg cttttcatga agatatggat      300

cgccttggtg tgctaaatgc agatattgag cctaaggcta cagattatat ccctgaaatg      360

atagagtgtt gtcaaaaatt actagaggct gataaagcat atattacagc ttcaggtgac      420

gtttatttta gagttcgttc tttccctgat tatggaaaac tttctggtag aactcctgat      480

gagttacgta taggagtacg tattgtacct agtgaggaga aagaagatcc tttagatttt      540

gttctttgga aagcagctaa gcctggagag ccttcttggg aaagtccttg gggaagaggg      600

cgtcctgggt ggcatattga atgttcagca atgagtgaaa agtgttggcc acttcctctt      660

gatatacatg ggggaggaat tgatcttatt tttccacacc atgaaaatga gattgctcag      720

actgaatcaa ttgtaaataa gccgttggct aaaatttgga tgcataatgg gcttgttcaa      780

gtaaattcag aaaaaatgtc aaaatctctt ggaaatttta agattgttag agatatatta      840

gaagcatatc tcccagaaac attacgtttt ttccttttaa aaaagcatta tagaagccct      900

atagattttt cttttgaagg aatgaatgag acagaacgaa gtcaaaaaag agtgtatgaa      960

tgtattgctg aggtagataa agcacttgaa agaaaatctt gggactcagg tggttcatct     1020

agctctattt tagctgagtt agatgaacaa ttttcactat ttatgtctgc gctagaagat     1080

gattgcaata cagctgctgg attaggtcat ttatttaata ttatccatat agttagacgt     1140

gctcttgatg ataaagctct ttactccaca actgatggga aggtggtttt tgaacaattt     1200

cgtgagatta tacgaaaagt agatatttta ttaggtgtat ttggtcaaaa acctaatagt     1260

tttttacaag atctcaaaac aattcgcatt attagaaata aaattgatgt taatcaagta     1320

gaagagttac ttagtaagag aaggcaagca agagaggaaa aaaattttgt tcaggcagat     1380

gaagttcgta ataccttagc ttcattaggt atagaaatac gtgacacttc agaaggtcag     1440

gtgtgggata ttttataa                                                   1458


<210>  20
<211>  485
<212>  PRT
<213>  Lawsonia intracellularis

<400>  20

Met His Leu Tyr Asn Thr Met Glu Lys Lys Lys Glu Pro Leu Ile Pro 
1               5                   10                  15      


Ile Ile Ser Gly Lys Leu Gly Ile Tyr Val Cys Gly Ile Thr Ala Tyr 
            20                  25                  30          


Asp Phe Ser His Ile Gly His Ala Arg Ser Ala Ile Val Phe Asp Ile 
        35                  40                  45              


Leu Val Arg Leu Leu Arg Tyr Gln Gly Tyr Asp Val Thr Phe Ile Arg 
    50                  55                  60                  


Asn Phe Thr Asp Ile Asp Asp Lys Ile Ile Asn Arg Ala Asn Lys Glu 
65                  70                  75                  80  


Gly Arg Ser Ser Lys Glu Val Ala Glu Glu Phe Ile Asn Ala Phe His 
                85                  90                  95      


Glu Asp Met Asp Arg Leu Gly Val Leu Asn Ala Asp Ile Glu Pro Lys 
            100                 105                 110         


Ala Thr Asp Tyr Ile Pro Glu Met Ile Glu Cys Cys Gln Lys Leu Leu 
        115                 120                 125             


Glu Ala Asp Lys Ala Tyr Ile Thr Ala Ser Gly Asp Val Tyr Phe Arg 
    130                 135                 140                 


Val Arg Ser Phe Pro Asp Tyr Gly Lys Leu Ser Gly Arg Thr Pro Asp 
145                 150                 155                 160 


Glu Leu Arg Ile Gly Val Arg Ile Val Pro Ser Glu Glu Lys Glu Asp 
                165                 170                 175     


Pro Leu Asp Phe Val Leu Trp Lys Ala Ala Lys Pro Gly Glu Pro Ser 
            180                 185                 190         


Trp Glu Ser Pro Trp Gly Arg Gly Arg Pro Gly Trp His Ile Glu Cys 
        195                 200                 205             


Ser Ala Met Ser Glu Lys Cys Trp Pro Leu Pro Leu Asp Ile His Gly 
    210                 215                 220                 


Gly Gly Ile Asp Leu Ile Phe Pro His His Glu Asn Glu Ile Ala Gln 
225                 230                 235                 240 


Thr Glu Ser Ile Val Asn Lys Pro Leu Ala Lys Ile Trp Met His Asn 
                245                 250                 255     


Gly Leu Val Gln Val Asn Ser Glu Lys Met Ser Lys Ser Leu Gly Asn 
            260                 265                 270         


Phe Lys Ile Val Arg Asp Ile Leu Glu Ala Tyr Leu Pro Glu Thr Leu 
        275                 280                 285             


Arg Phe Phe Leu Leu Lys Lys His Tyr Arg Ser Pro Ile Asp Phe Ser 
    290                 295                 300                 


Phe Glu Gly Met Asn Glu Thr Glu Arg Ser Gln Lys Arg Val Tyr Glu 
305                 310                 315                 320 


Cys Ile Ala Glu Val Asp Lys Ala Leu Glu Arg Lys Ser Trp Asp Ser 
                325                 330                 335     


Gly Gly Ser Ser Ser Ser Ile Leu Ala Glu Leu Asp Glu Gln Phe Ser 
            340                 345                 350         


Leu Phe Met Ser Ala Leu Glu Asp Asp Cys Asn Thr Ala Ala Gly Leu 
        355                 360                 365             


Gly His Leu Phe Asn Ile Ile His Ile Val Arg Arg Ala Leu Asp Asp 
    370                 375                 380                 


Lys Ala Leu Tyr Ser Thr Thr Asp Gly Lys Val Val Phe Glu Gln Phe 
385                 390                 395                 400 


Arg Glu Ile Ile Arg Lys Val Asp Ile Leu Leu Gly Val Phe Gly Gln 
                405                 410                 415     


Lys Pro Asn Ser Phe Leu Gln Asp Leu Lys Thr Ile Arg Ile Ile Arg 
            420                 425                 430         


Asn Lys Ile Asp Val Asn Gln Val Glu Glu Leu Leu Ser Lys Arg Arg 
        435                 440                 445             


Gln Ala Arg Glu Glu Lys Asn Phe Val Gln Ala Asp Glu Val Arg Asn 
    450                 455                 460                 


Thr Leu Ala Ser Leu Gly Ile Glu Ile Arg Asp Thr Ser Glu Gly Gln 
465                 470                 475                 480 


Val Trp Asp Ile Leu 
                485 


<210>  21
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  21

Met His His His His His His Gly Ser Met His Leu Tyr Asn Thr Met 
1               5                   10                  15      


Glu Lys Lys Lys Glu Pro Leu Ile Pro Ile Ile Ser Gly Lys Leu Gly 
            20                  25                  30          


Ile Tyr Val Cys Gly Ile Thr Ala Tyr Asp Phe Ser His Ile Gly His 
        35                  40                  45              


Ala Arg Ser Ala Ile Val Phe Asp Ile Leu Val Arg Leu Leu Arg Tyr 
    50                  55                  60                  


Gln Gly Tyr Asp Val Thr Phe Ile Arg Asn Phe Thr Asp Ile Asp Asp 
65                  70                  75                  80  


Lys Ile Ile Asn Arg Ala Asn Lys Glu Gly Arg Ser Ser Lys Glu Val 
                85                  90                  95      


Ala Glu Glu Phe Ile Asn Ala Phe His Glu Asp Met Asp Arg Leu Gly 
            100                 105                 110         


Val Leu Asn Ala Asp Ile Glu Pro Lys Ala Thr Asp Tyr Ile Pro Glu 
        115                 120                 125             


Met Ile Glu Cys Cys Gln Lys Leu Leu Glu Ala Asp Lys Ala Tyr Ile 
    130                 135                 140                 


Thr Ala Ser Gly Asp Val Tyr Phe Arg Val Arg Ser Phe Pro Asp Tyr 
145                 150                 155                 160 


Gly Lys Leu Ser Gly Arg Thr Pro Asp Glu Leu Arg Ile Gly Val Arg 
                165                 170                 175     


Ile Val Pro Ser Glu Glu Lys Glu Asp Pro Leu Asp Phe Val Leu Trp 
            180                 185                 190         


Lys Ala Ala Lys Pro Gly Glu Pro Ser Trp Glu Ser Pro Trp Gly Arg 
        195                 200                 205             


Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ser Glu Lys Cys 
    210                 215                 220                 


Trp Pro Leu Pro Leu Asp Ile His Gly Gly Gly Ile Asp Leu Ile Phe 
225                 230                 235                 240 


Pro His His Glu Asn Glu Ile Ala Gln Thr Glu Ser Ile Val Asn Lys 
                245                 250                 255     


Pro Leu Ala Lys Ile Trp Met His Asn Gly Leu Val Gln Val Asn Ser 
            260                 265                 270         


Glu Lys Met Ser Lys Ser Leu Gly Asn Phe Lys Ile Val Arg Asp Ile 
        275                 280                 285             


Leu Glu Ala Tyr Leu Pro Glu Thr Leu Arg Phe Phe Leu Leu Lys Lys 
    290                 295                 300                 


His Tyr Arg Ser Pro Ile Asp Phe Ser Phe Glu Gly Met Asn Glu Thr 
305                 310                 315                 320 


Glu Arg Ser Gln Lys Arg Val Tyr Glu Cys Ile Ala Glu Val Asp Lys 
                325                 330                 335     


Ala Leu Glu Arg Lys Ser Trp Asp Ser Gly Gly Ser Ser Ser Ser Ile 
            340                 345                 350         


Leu Ala Glu Leu Asp Glu Gln Phe Ser Leu Phe Met Ser Ala Leu Glu 
        355                 360                 365             


Asp Asp Cys Asn Thr Ala Ala Gly Leu Gly His Leu Phe Asn Ile Ile 
    370                 375                 380                 


His Ile Val Arg Arg Ala Leu Asp Asp Lys Ala Leu Tyr Ser Thr Thr 
385                 390                 395                 400 


Asp Gly Lys Val Val Phe Glu Gln Phe Arg Glu Ile Ile Arg Lys Val 
                405                 410                 415     


Asp Ile Leu Leu Gly Val Phe Gly Gln Lys Pro Asn Ser Phe Leu Gln 
            420                 425                 430         


Asp Leu Lys Thr Ile Arg Ile Ile Arg Asn Lys Ile Asp Val Asn Gln 
        435                 440                 445             


Val Glu Glu Leu Leu Ser Lys Arg Arg Gln Ala Arg Glu Glu Lys Asn 
    450                 455                 460                 


Phe Val Gln Ala Asp Glu Val Arg Asn Thr Leu Ala Ser Leu Gly Ile 
465                 470                 475                 480 


Glu Ile Arg Asp Thr Ser Glu Gly Gln Val Trp Asp Ile Leu 
                485                 490                 


<210>  22
<211>  1215
<212>  DNA
<213>  Lawsonia intracellularis

<400>  22
ttgatacagt tttttgcttg tatttttagg ggagaagata tgaccattga aaaggggaga       60

tactttttta cctctgaatc agtaacagaa ggtcatccag ataaagttgc tgatcaaatt      120

tctgatgctg ttttagatac gttgttagag caagatccac attctagagt agcttgtgag      180

gctttagttt ctactgggat ggctattatc gctggggaaa ttacaacaaa tggttatgca      240

gatttgctaa gtgtagttcg aaggaccata cagtccattg gttataatag ttctgagatg      300

ggttttgact ggcagacatg tgcagttctt tccacaattg ataagcaatc attagatatt      360

gctcagggaa ttgatcgtgc aaaacctgaa gagcaaggtg caggagatca gggaatgatg      420

tttggttttg cttgtagaga aactccaacg ttaatgccag cacctattta ttgggcacat      480

cagctttctc aaaaattaac aaaagtacga aaagatggag aagtgtcctt ttttcggcca      540

gatgggaaaa cacaaatatc ttttgagtat tataatgggg ttcctgtaag aattaacaac      600

gttgttgttt ctacacaaca tgccccttct gtatcacaaa gtgaccttat tgaagctgtt      660

aagagtaaag tgattcgtcc tgtacttgaa cctacaggaa tgttcgatga gaaagaatgc      720

gaaatatata ttaatacaac aggacgtttt gttgttggtg gccctatggg tgattgtggt      780

ttgacaggaa gaaaaattat tcaagatacg tatggggggt caggccatca tggcggtgga      840

gctttctcag ggaaagatgc ctcaaaagtt gatcgttcag gagcatatat ggctcgttat      900

attgcaaaaa atgtagttgg tactggatta gcacaacgct gtgaagtaca aattgcttat      960

tgtattggtg tagcaaagcc tgtttctgtt ttagtatctt ctttaggtac aagcgatatt     1020

cctgatgaag tcttaacaaa agctgtactt gaggtttttg atctaagacc ttattttatt     1080

acaaagcgtt tagatttact aagaccaatt tatagtaaga cttcttgtta tgggcatttt     1140

ggaagagaat tacctgaatt tacttgggaa caattagatg ctgttaaaga tttacaaaca     1200

gctttaaaaa tataa                                                      1215


<210>  23
<211>  404
<212>  PRT
<213>  Lawsonia intracellularis

<400>  23

Met Ile Gln Phe Phe Ala Cys Ile Phe Arg Gly Glu Asp Met Thr Ile 
1               5                   10                  15      


Glu Lys Gly Arg Tyr Phe Phe Thr Ser Glu Ser Val Thr Glu Gly His 
            20                  25                  30          


Pro Asp Lys Val Ala Asp Gln Ile Ser Asp Ala Val Leu Asp Thr Leu 
        35                  40                  45              


Leu Glu Gln Asp Pro His Ser Arg Val Ala Cys Glu Ala Leu Val Ser 
    50                  55                  60                  


Thr Gly Met Ala Ile Ile Ala Gly Glu Ile Thr Thr Asn Gly Tyr Ala 
65                  70                  75                  80  


Asp Leu Leu Ser Val Val Arg Arg Thr Ile Gln Ser Ile Gly Tyr Asn 
                85                  90                  95      


Ser Ser Glu Met Gly Phe Asp Trp Gln Thr Cys Ala Val Leu Ser Thr 
            100                 105                 110         


Ile Asp Lys Gln Ser Leu Asp Ile Ala Gln Gly Ile Asp Arg Ala Lys 
        115                 120                 125             


Pro Glu Glu Gln Gly Ala Gly Asp Gln Gly Met Met Phe Gly Phe Ala 
    130                 135                 140                 


Cys Arg Glu Thr Pro Thr Leu Met Pro Ala Pro Ile Tyr Trp Ala His 
145                 150                 155                 160 


Gln Leu Ser Gln Lys Leu Thr Lys Val Arg Lys Asp Gly Glu Val Ser 
                165                 170                 175     


Phe Phe Arg Pro Asp Gly Lys Thr Gln Ile Ser Phe Glu Tyr Tyr Asn 
            180                 185                 190         


Gly Val Pro Val Arg Ile Asn Asn Val Val Val Ser Thr Gln His Ala 
        195                 200                 205             


Pro Ser Val Ser Gln Ser Asp Leu Ile Glu Ala Val Lys Ser Lys Val 
    210                 215                 220                 


Ile Arg Pro Val Leu Glu Pro Thr Gly Met Phe Asp Glu Lys Glu Cys 
225                 230                 235                 240 


Glu Ile Tyr Ile Asn Thr Thr Gly Arg Phe Val Val Gly Gly Pro Met 
                245                 250                 255     


Gly Asp Cys Gly Leu Thr Gly Arg Lys Ile Ile Gln Asp Thr Tyr Gly 
            260                 265                 270         


Gly Ser Gly His His Gly Gly Gly Ala Phe Ser Gly Lys Asp Ala Ser 
        275                 280                 285             


Lys Val Asp Arg Ser Gly Ala Tyr Met Ala Arg Tyr Ile Ala Lys Asn 
    290                 295                 300                 


Val Val Gly Thr Gly Leu Ala Gln Arg Cys Glu Val Gln Ile Ala Tyr 
305                 310                 315                 320 


Cys Ile Gly Val Ala Lys Pro Val Ser Val Leu Val Ser Ser Leu Gly 
                325                 330                 335     


Thr Ser Asp Ile Pro Asp Glu Val Leu Thr Lys Ala Val Leu Glu Val 
            340                 345                 350         


Phe Asp Leu Arg Pro Tyr Phe Ile Thr Lys Arg Leu Asp Leu Leu Arg 
        355                 360                 365             


Pro Ile Tyr Ser Lys Thr Ser Cys Tyr Gly His Phe Gly Arg Glu Leu 
    370                 375                 380                 


Pro Glu Phe Thr Trp Glu Gln Leu Asp Ala Val Lys Asp Leu Gln Thr 
385                 390                 395                 400 


Ala Leu Lys Ile 
                


<210>  24
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  24

Met His His His His His His Gly Ser Met Thr Ile Glu Lys Gly Arg 
1               5                   10                  15      


Tyr Phe Phe Thr Ser Glu Ser Val Thr Glu Gly His Pro Asp Lys Val 
            20                  25                  30          


Ala Asp Gln Ile Ser Asp Ala Val Leu Asp Thr Leu Leu Glu Gln Asp 
        35                  40                  45              


Pro His Ser Arg Val Ala Cys Glu Ala Leu Val Ser Thr Gly Met Ala 
    50                  55                  60                  


Ile Ile Ala Gly Glu Ile Thr Thr Asn Gly Tyr Ala Asp Leu Leu Ser 
65                  70                  75                  80  


Val Val Arg Arg Thr Ile Gln Ser Ile Gly Tyr Asn Ser Ser Glu Met 
                85                  90                  95      


Gly Phe Asp Trp Gln Thr Cys Ala Val Leu Ser Thr Ile Asp Lys Gln 
            100                 105                 110         


Ser Leu Asp Ile Ala Gln Gly Ile Asp Arg Ala Lys Pro Glu Glu Gln 
        115                 120                 125             


Gly Ala Gly Asp Gln Gly Met Met Phe Gly Phe Ala Cys Arg Glu Thr 
    130                 135                 140                 


Pro Thr Leu Met Pro Ala Pro Ile Tyr Trp Ala His Gln Leu Ser Gln 
145                 150                 155                 160 


Lys Leu Thr Lys Val Arg Lys Asp Gly Glu Val Ser Phe Phe Arg Pro 
                165                 170                 175     


Asp Gly Lys Thr Gln Ile Ser Phe Glu Tyr Tyr Asn Gly Val Pro Val 
            180                 185                 190         


Arg Ile Asn Asn Val Val Val Ser Thr Gln His Ala Pro Ser Val Ser 
        195                 200                 205             


Gln Ser Asp Leu Ile Glu Ala Val Lys Ser Lys Val Ile Arg Pro Val 
    210                 215                 220                 


Leu Glu Pro Thr Gly Met Phe Asp Glu Lys Glu Cys Glu Ile Tyr Ile 
225                 230                 235                 240 


Asn Thr Thr Gly Arg Phe Val Val Gly Gly Pro Met Gly Asp Cys Gly 
                245                 250                 255     


Leu Thr Gly Arg Lys Ile Ile Gln Asp Thr Tyr Gly Gly Ser Gly His 
            260                 265                 270         


His Gly Gly Gly Ala Phe Ser Gly Lys Asp Ala Ser Lys Val Asp Arg 
        275                 280                 285             


Ser Gly Ala Tyr Met Ala Arg Tyr Ile Ala Lys Asn Val Val Gly Thr 
    290                 295                 300                 


Gly Leu Ala Gln Arg Cys Glu Val Gln Ile Ala Tyr Cys Ile Gly Val 
305                 310                 315                 320 


Ala Lys Pro Val Ser Val Leu Val Ser Ser Leu Gly Thr Ser Asp Ile 
                325                 330                 335     


Pro Asp Glu Val Leu Thr Lys Ala Val Leu Glu Val Phe Asp Leu Arg 
            340                 345                 350         


Pro Tyr Phe Ile Thr Lys Arg Leu Asp Leu Leu Arg Pro Ile Tyr Ser 
        355                 360                 365             


Lys Thr Ser Cys Tyr Gly His Phe Gly Arg Glu Leu Pro Glu Phe Thr 
    370                 375                 380                 


Trp Glu Gln Leu Asp Ala Val Lys Asp Leu Gln Thr Ala Leu Lys Ile 
385                 390                 395                 400 


<210>  25
<211>  1092
<212>  DNA
<213>  Lawsonia intracellularis

<400>  25
ttggatatac tacttccctt tgaaaaaaga cgtgaacagt tacataaggt tatgtctgaa       60

agaaaactgg atggactttt agtatatcat gctgctaata gatactattt atcaggtttt      120

gaattacata atcctcaatg taatgaaagt gcaggctgtt taattatatt agctaatggt      180

aaagactggt tatgtacaga ctcaaggtac actgaggcag caaaacgtct atgggatgag      240

gatttcatat atagttatgg acacaacatt ccagaacaac ttggattact tataaataaa      300

atattaccaa aaggtagctg tattggtttt gagtcaaaag tactttcagt aaattttttt      360

gaagcttttg ttgaacaatt acaagatatt acacctgtaa gtgctgatgg tatagttgaa      420

gatttaagag taataaaaga cgaacaagaa gttcgattaa tggaacaatc gtgtttatta      480

aaccatcaac ttttaacctg ggttccatca atattgcgtc ctggagagag tgaagcttct      540

gtttcttggg aaatagaatt attttttaga aaacatggtg caaatgaatt agctttccca      600

agtattgttg catctggagg taatgcagca ttacctcatg ctattccaag ttcagataca      660

caaattgaga gtgaagagtt agtacttgtg gatgttggtg ctaggctata tgattattgt      720

tcggatcaaa cacggacatt ttgggttgga gataatccct ctaaacgttt tcagcaaaca      780

ttagcattag tacaggaggc acagcataga gctattaaag ctattcagcc tggagtgtta      840

gcaaaagatg tgtataacac agtttataca ttttttatag aatatggggt agaaaaagct      900

tttaagcata atcttggaca tggagttggt cttgaagtgc atgaagcacc ctcattaggg      960

ccacgtagtg aaacaatcct taaacctggg atggttatta ctgttgagcc aggcttatat     1020

tatcctgagt ggggaggagt ccgttgggag catatggtgc ttgttacaga agatggtgca     1080

aaagtatttt aa                                                         1092


<210>  26
<211>  363
<212>  PRT
<213>  Lawsonia intracellularis

<400>  26

Met Asp Ile Leu Leu Pro Phe Glu Lys Arg Arg Glu Gln Leu His Lys 
1               5                   10                  15      


Val Met Ser Glu Arg Lys Leu Asp Gly Leu Leu Val Tyr His Ala Ala 
            20                  25                  30          


Asn Arg Tyr Tyr Leu Ser Gly Phe Glu Leu His Asn Pro Gln Cys Asn 
        35                  40                  45              


Glu Ser Ala Gly Cys Leu Ile Ile Leu Ala Asn Gly Lys Asp Trp Leu 
    50                  55                  60                  


Cys Thr Asp Ser Arg Tyr Thr Glu Ala Ala Lys Arg Leu Trp Asp Glu 
65                  70                  75                  80  


Asp Phe Ile Tyr Ser Tyr Gly His Asn Ile Pro Glu Gln Leu Gly Leu 
                85                  90                  95      


Leu Ile Asn Lys Ile Leu Pro Lys Gly Ser Cys Ile Gly Phe Glu Ser 
            100                 105                 110         


Lys Val Leu Ser Val Asn Phe Phe Glu Ala Phe Val Glu Gln Leu Gln 
        115                 120                 125             


Asp Ile Thr Pro Val Ser Ala Asp Gly Ile Val Glu Asp Leu Arg Val 
    130                 135                 140                 


Ile Lys Asp Glu Gln Glu Val Arg Leu Met Glu Gln Ser Cys Leu Leu 
145                 150                 155                 160 


Asn His Gln Leu Leu Thr Trp Val Pro Ser Ile Leu Arg Pro Gly Glu 
                165                 170                 175     


Ser Glu Ala Ser Val Ser Trp Glu Ile Glu Leu Phe Phe Arg Lys His 
            180                 185                 190         


Gly Ala Asn Glu Leu Ala Phe Pro Ser Ile Val Ala Ser Gly Gly Asn 
        195                 200                 205             


Ala Ala Leu Pro His Ala Ile Pro Ser Ser Asp Thr Gln Ile Glu Ser 
    210                 215                 220                 


Glu Glu Leu Val Leu Val Asp Val Gly Ala Arg Leu Tyr Asp Tyr Cys 
225                 230                 235                 240 


Ser Asp Gln Thr Arg Thr Phe Trp Val Gly Asp Asn Pro Ser Lys Arg 
                245                 250                 255     


Phe Gln Gln Thr Leu Ala Leu Val Gln Glu Ala Gln His Arg Ala Ile 
            260                 265                 270         


Lys Ala Ile Gln Pro Gly Val Leu Ala Lys Asp Val Tyr Asn Thr Val 
        275                 280                 285             


Tyr Thr Phe Phe Ile Glu Tyr Gly Val Glu Lys Ala Phe Lys His Asn 
    290                 295                 300                 


Leu Gly His Gly Val Gly Leu Glu Val His Glu Ala Pro Ser Leu Gly 
305                 310                 315                 320 


Pro Arg Ser Glu Thr Ile Leu Lys Pro Gly Met Val Ile Thr Val Glu 
                325                 330                 335     


Pro Gly Leu Tyr Tyr Pro Glu Trp Gly Gly Val Arg Trp Glu His Met 
            340                 345                 350         


Val Leu Val Thr Glu Asp Gly Ala Lys Val Phe 
        355                 360             


<210>  27
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  27

Met His His His His His His Gly Ser Met Asp Ile Leu Leu Pro Phe 
1               5                   10                  15      


Glu Lys Arg Arg Glu Gln Leu His Lys Val Met Ser Glu Arg Lys Leu 
            20                  25                  30          


Asp Gly Leu Leu Val Tyr His Ala Ala Asn Arg Tyr Tyr Leu Ser Gly 
        35                  40                  45              


Phe Glu Leu His Asn Pro Gln Cys Asn Glu Ser Ala Gly Cys Leu Ile 
    50                  55                  60                  


Ile Leu Ala Asn Gly Lys Asp Trp Leu Cys Thr Asp Ser Arg Tyr Thr 
65                  70                  75                  80  


Glu Ala Ala Lys Arg Leu Trp Asp Glu Asp Phe Ile Tyr Ser Tyr Gly 
                85                  90                  95      


His Asn Ile Pro Glu Gln Leu Gly Leu Leu Ile Asn Lys Ile Leu Pro 
            100                 105                 110         


Lys Gly Ser Cys Ile Gly Phe Glu Ser Lys Val Leu Ser Val Asn Phe 
        115                 120                 125             


Phe Glu Ala Phe Val Glu Gln Leu Gln Asp Ile Thr Pro Val Ser Ala 
    130                 135                 140                 


Asp Gly Ile Val Glu Asp Leu Arg Val Ile Lys Asp Glu Gln Glu Val 
145                 150                 155                 160 


Arg Leu Met Glu Gln Ser Cys Leu Leu Asn His Gln Leu Leu Thr Trp 
                165                 170                 175     


Val Pro Ser Ile Leu Arg Pro Gly Glu Ser Glu Ala Ser Val Ser Trp 
            180                 185                 190         


Glu Ile Glu Leu Phe Phe Arg Lys His Gly Ala Asn Glu Leu Ala Phe 
        195                 200                 205             


Pro Ser Ile Val Ala Ser Gly Gly Asn Ala Ala Leu Pro His Ala Ile 
    210                 215                 220                 


Pro Ser Ser Asp Thr Gln Ile Glu Ser Glu Glu Leu Val Leu Val Asp 
225                 230                 235                 240 


Val Gly Ala Arg Leu Tyr Asp Tyr Cys Ser Asp Gln Thr Arg Thr Phe 
                245                 250                 255     


Trp Val Gly Asp Asn Pro Ser Lys Arg Phe Gln Gln Thr Leu Ala Leu 
            260                 265                 270         


Val Gln Glu Ala Gln His Arg Ala Ile Lys Ala Ile Gln Pro Gly Val 
        275                 280                 285             


Leu Ala Lys Asp Val Tyr Asn Thr Val Tyr Thr Phe Phe Ile Glu Tyr 
    290                 295                 300                 


Gly Val Glu Lys Ala Phe Lys His Asn Leu Gly His Gly Val Gly Leu 
305                 310                 315                 320 


Glu Val His Glu Ala Pro Ser Leu Gly Pro Arg Ser Glu Thr Ile Leu 
                325                 330                 335     


Lys Pro Gly Met Val Ile Thr Val Glu Pro Gly Leu Tyr Tyr Pro Glu 
            340                 345                 350         


Trp Gly Gly Val Arg Trp Glu His Met Val Leu Val Thr Glu Asp Gly 
        355                 360                 365             


Ala Lys Val Phe 
    370         


<210>  28
<211>  1647
<212>  DNA
<213>  Lawsonia intracellularis

<400>  28
atggcttcta aagaaatcct ttttgatgct aaagcccgtg aaaaactttc acgaggtgta       60

gataaacttg caaatgctgt taaagtaaca cttggaccta aaggccgtaa tgtcgttatt      120

gaaaagtctt ttggttcccc agttattaca aaagatggtg tatctgttgc aaaagaaatt      180

gaacttgaag ataagtttga aaatatgggc gctcaaatgg ttaaagaagt agcttccaaa      240

actagcgata ttgctggtga tggaactaca acagcaacag tccttgcaca agctatttat      300

cgtgaaggtg taaaacttgt agcagctggt cgtaatccta tggccattaa acgtggcata      360

gataaagctg ttgttgctgt tactaaagaa ctaagcgaca ttacaaagcc tactcgtgac      420

caaaaagaaa tagctcaagt tggaaccatt tctgcaaact ctgatacaac aataggtaat      480

atcatagctg aagctatggc taaagttgga aaagaaggtg ttatcacagt tgaggaagct      540

aaaggtcttg aaactacatt agatgtggtt gaaggaatga agtttgaccg tggctacctc      600

tctccatact ttgtaactaa tcctgagaaa atggtttgtg aacttgataa cccttatatc      660

ctttgtaatg agaaaaagat tactagcatg aaagacatgc taccaatctt agaacaagtt      720

gctaaagtaa accgtccact ccttattatt gctgaagacg tagaaggtga agcacttgca      780

acacttgtag tcaataagct ccgtggagca ctccaagttg tagccgtaaa agctcctggt      840

tttggtgaac gccgtaaagc tatgcttgaa gatattgcta tccttactgg aggagaagca      900

atatttgaag atcgtggtat aaagcttgaa aatgtaagct tgtcttcttt aggaacagct      960

aaacgtgtag ttattgacaa agaaaatact actatcgttg atggtgctgg aaaatcagaa     1020

gatattaaag ctcgagttaa acaaattcgt gcacaaattg aagaaacaag ctcagattat     1080

gatcgtgaaa aacttcaaga acgtcttgca aaacttgttg gtggagtagc tgttatccat     1140

gttggagctg ctactgaaac tgaaatgaaa gagaagaagg atcgtgtaga agatgctcta     1200

aatgcaacaa gagctgcggt tgaagaaggt attgtccctg gtggtggtac tgcttttgtc     1260

cgctccatta aagtccttga tgatattaaa cctgctgatg atgatgaact tgctggactt     1320

aatatcatcc gtcgttctct tgaagagcct ttacgtcaaa ttgctgcaaa tgctggctat     1380

gaaggttcta ttgttgtaga aaaagttcgt gaagcaaaag atggttttgg atttaatgct     1440

gcatcaggag aatatgaaga ccttattaaa gctggtgtca ttgatcctaa aaaagttaca     1500

cgtattgcat tacaaaatgc agcatcagta gcctccttac ttctaactac agaatgcgct     1560

attgctgaaa aaccagaacc taaaaaagat atgcctatgc ctggcggtgg tatgggtggt     1620

atgggtggta tggacggtat gtactag                                         1647


<210>  29
<211>  548
<212>  PRT
<213>  Lawsonia intracellularis

<400>  29

Met Ala Ser Lys Glu Ile Leu Phe Asp Ala Lys Ala Arg Glu Lys Leu 
1               5                   10                  15      


Ser Arg Gly Val Asp Lys Leu Ala Asn Ala Val Lys Val Thr Leu Gly 
            20                  25                  30          


Pro Lys Gly Arg Asn Val Val Ile Glu Lys Ser Phe Gly Ser Pro Val 
        35                  40                  45              


Ile Thr Lys Asp Gly Val Ser Val Ala Lys Glu Ile Glu Leu Glu Asp 
    50                  55                  60                  


Lys Phe Glu Asn Met Gly Ala Gln Met Val Lys Glu Val Ala Ser Lys 
65                  70                  75                  80  


Thr Ser Asp Ile Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala 
                85                  90                  95      


Gln Ala Ile Tyr Arg Glu Gly Val Lys Leu Val Ala Ala Gly Arg Asn 
            100                 105                 110         


Pro Met Ala Ile Lys Arg Gly Ile Asp Lys Ala Val Val Ala Val Thr 
        115                 120                 125             


Lys Glu Leu Ser Asp Ile Thr Lys Pro Thr Arg Asp Gln Lys Glu Ile 
    130                 135                 140                 


Ala Gln Val Gly Thr Ile Ser Ala Asn Ser Asp Thr Thr Ile Gly Asn 
145                 150                 155                 160 


Ile Ile Ala Glu Ala Met Ala Lys Val Gly Lys Glu Gly Val Ile Thr 
                165                 170                 175     


Val Glu Glu Ala Lys Gly Leu Glu Thr Thr Leu Asp Val Val Glu Gly 
            180                 185                 190         


Met Lys Phe Asp Arg Gly Tyr Leu Ser Pro Tyr Phe Val Thr Asn Pro 
        195                 200                 205             


Glu Lys Met Val Cys Glu Leu Asp Asn Pro Tyr Ile Leu Cys Asn Glu 
    210                 215                 220                 


Lys Lys Ile Thr Ser Met Lys Asp Met Leu Pro Ile Leu Glu Gln Val 
225                 230                 235                 240 


Ala Lys Val Asn Arg Pro Leu Leu Ile Ile Ala Glu Asp Val Glu Gly 
                245                 250                 255     


Glu Ala Leu Ala Thr Leu Val Val Asn Lys Leu Arg Gly Ala Leu Gln 
            260                 265                 270         


Val Val Ala Val Lys Ala Pro Gly Phe Gly Glu Arg Arg Lys Ala Met 
        275                 280                 285             


Leu Glu Asp Ile Ala Ile Leu Thr Gly Gly Glu Ala Ile Phe Glu Asp 
    290                 295                 300                 


Arg Gly Ile Lys Leu Glu Asn Val Ser Leu Ser Ser Leu Gly Thr Ala 
305                 310                 315                 320 


Lys Arg Val Val Ile Asp Lys Glu Asn Thr Thr Ile Val Asp Gly Ala 
                325                 330                 335     


Gly Lys Ser Glu Asp Ile Lys Ala Arg Val Lys Gln Ile Arg Ala Gln 
            340                 345                 350         


Ile Glu Glu Thr Ser Ser Asp Tyr Asp Arg Glu Lys Leu Gln Glu Arg 
        355                 360                 365             


Leu Ala Lys Leu Val Gly Gly Val Ala Val Ile His Val Gly Ala Ala 
    370                 375                 380                 


Thr Glu Thr Glu Met Lys Glu Lys Lys Asp Arg Val Glu Asp Ala Leu 
385                 390                 395                 400 


Asn Ala Thr Arg Ala Ala Val Glu Glu Gly Ile Val Pro Gly Gly Gly 
                405                 410                 415     


Thr Ala Phe Val Arg Ser Ile Lys Val Leu Asp Asp Ile Lys Pro Ala 
            420                 425                 430         


Asp Asp Asp Glu Leu Ala Gly Leu Asn Ile Ile Arg Arg Ser Leu Glu 
        435                 440                 445             


Glu Pro Leu Arg Gln Ile Ala Ala Asn Ala Gly Tyr Glu Gly Ser Ile 
    450                 455                 460                 


Val Val Glu Lys Val Arg Glu Ala Lys Asp Gly Phe Gly Phe Asn Ala 
465                 470                 475                 480 


Ala Ser Gly Glu Tyr Glu Asp Leu Ile Lys Ala Gly Val Ile Asp Pro 
                485                 490                 495     


Lys Lys Val Thr Arg Ile Ala Leu Gln Asn Ala Ala Ser Val Ala Ser 
            500                 505                 510         


Leu Leu Leu Thr Thr Glu Cys Ala Ile Ala Glu Lys Pro Glu Pro Lys 
        515                 520                 525             


Lys Asp Met Pro Met Pro Gly Gly Gly Met Gly Gly Met Gly Gly Met 
    530                 535                 540                 


Asp Gly Met Tyr 
545             


<210>  30
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  30

Met His His His His His His Gly Ser Met Ala Ser Lys Glu Ile Leu 
1               5                   10                  15      


Phe Asp Ala Lys Ala Arg Glu Lys Leu Ser Arg Gly Val Asp Lys Leu 
            20                  25                  30          


Ala Asn Ala Val Lys Val Thr Leu Gly Pro Lys Gly Arg Asn Val Val 
        35                  40                  45              


Ile Glu Lys Ser Phe Gly Ser Pro Val Ile Thr Lys Asp Gly Val Ser 
    50                  55                  60                  


Val Ala Lys Glu Ile Glu Leu Glu Asp Lys Phe Glu Asn Met Gly Ala 
65                  70                  75                  80  


Gln Met Val Lys Glu Val Ala Ser Lys Thr Ser Asp Ile Ala Gly Asp 
                85                  90                  95      


Gly Thr Thr Thr Ala Thr Val Leu Ala Gln Ala Ile Tyr Arg Glu Gly 
            100                 105                 110         


Val Lys Leu Val Ala Ala Gly Arg Asn Pro Met Ala Ile Lys Arg Gly 
        115                 120                 125             


Ile Asp Lys Ala Val Val Ala Val Thr Lys Glu Leu Ser Asp Ile Thr 
    130                 135                 140                 


Lys Pro Thr Arg Asp Gln Lys Glu Ile Ala Gln Val Gly Thr Ile Ser 
145                 150                 155                 160 


Ala Asn Ser Asp Thr Thr Ile Gly Asn Ile Ile Ala Glu Ala Met Ala 
                165                 170                 175     


Lys Val Gly Lys Glu Gly Val Ile Thr Val Glu Glu Ala Lys Gly Leu 
            180                 185                 190         


Glu Thr Thr Leu Asp Val Val Glu Gly Met Lys Phe Asp Arg Gly Tyr 
        195                 200                 205             


Leu Ser Pro Tyr Phe Val Thr Asn Pro Glu Lys Met Val Cys Glu Leu 
    210                 215                 220                 


Asp Asn Pro Tyr Ile Leu Cys Asn Glu Lys Lys Ile Thr Ser Met Lys 
225                 230                 235                 240 


Asp Met Leu Pro Ile Leu Glu Gln Val Ala Lys Val Asn Arg Pro Leu 
                245                 250                 255     


Leu Ile Ile Ala Glu Asp Val Glu Gly Glu Ala Leu Ala Thr Leu Val 
            260                 265                 270         


Val Asn Lys Leu Arg Gly Ala Leu Gln Val Val Ala Val Lys Ala Pro 
        275                 280                 285             


Gly Phe Gly Glu Arg Arg Lys Ala Met Leu Glu Asp Ile Ala Ile Leu 
    290                 295                 300                 


Thr Gly Gly Glu Ala Ile Phe Glu Asp Arg Gly Ile Lys Leu Glu Asn 
305                 310                 315                 320 


Val Ser Leu Ser Ser Leu Gly Thr Ala Lys Arg Val Val Ile Asp Lys 
                325                 330                 335     


Glu Asn Thr Thr Ile Val Asp Gly Ala Gly Lys Ser Glu Asp Ile Lys 
            340                 345                 350         


Ala Arg Val Lys Gln Ile Arg Ala Gln Ile Glu Glu Thr Ser Ser Asp 
        355                 360                 365             


Tyr Asp Arg Glu Lys Leu Gln Glu Arg Leu Ala Lys Leu Val Gly Gly 
    370                 375                 380                 


Val Ala Val Ile His Val Gly Ala Ala Thr Glu Thr Glu Met Lys Glu 
385                 390                 395                 400 


Lys Lys Asp Arg Val Glu Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
                405                 410                 415     


Glu Glu Gly Ile Val Pro Gly Gly Gly Thr Ala Phe Val Arg Ser Ile 
            420                 425                 430         


Lys Val Leu Asp Asp Ile Lys Pro Ala Asp Asp Asp Glu Leu Ala Gly 
        435                 440                 445             


Leu Asn Ile Ile Arg Arg Ser Leu Glu Glu Pro Leu Arg Gln Ile Ala 
    450                 455                 460                 


Ala Asn Ala Gly Tyr Glu Gly Ser Ile Val Val Glu Lys Val Arg Glu 
465                 470                 475                 480 


Ala Lys Asp Gly Phe Gly Phe Asn Ala Ala Ser Gly Glu Tyr Glu Asp 
                485                 490                 495     


Leu Ile Lys Ala Gly Val Ile Asp Pro Lys Lys Val Thr Arg Ile Ala 
            500                 505                 510         


Leu Gln Asn Ala Ala Ser Val Ala Ser Leu Leu Leu Thr Thr Glu Cys 
        515                 520                 525             


Ala Ile Ala Glu Lys Pro Glu Pro Lys Lys Asp Met Pro Met Pro Gly 
    530                 535                 540                 


Gly Gly Met Gly Gly Met Gly Gly Met Asp Gly Met Tyr 
545                 550                 555         


<210>  31
<211>  630
<212>  DNA
<213>  Lawsonia intracellularis

<400>  31
atggatgata tttttaatat gacagtccct attgttgttg aaaataacgg aagaaatgaa       60

agagcttatg atatttactc aagactacta aaagatcgta ttgttcttct tggtacagaa      120

gtaaatgatc aagtagcatc ccttatttgt gcacaacttt tatttttaga gtcacaggat      180

ccagaaaaag aaatttattt atatattaat agccctggag gttcagtaac tgcaggtctc      240

gcaatatatg atactatgaa ctatattaca ccaaatgtag caacggtttg tatggggcgt      300

gccgcaagta tgggtgcttt gttattagct gctggtgaaa aaaatatgcg ttatgcctta      360

cctaatagcc aggtaatgat tcatcagcca ttaggcggtt accaaggaca agctacagat      420

attgatatcc atgccagaga aattttacgt atgcgtcaac ggttaaatga aattttgatg      480

gagcagacag gacagtcact tgaaaaggtt gcacaagata ctgagcgtga ctattttatg      540

acggcagaag atgctaaagc ttatggactt attgataaag tcttggtttc ccgaaaagat      600

ttagatatag agcatgaaaa aacagaataa                                       630


<210>  32
<211>  209
<212>  PRT
<213>  Lawsonia intracellularis

<400>  32

Met Asp Asp Ile Phe Asn Met Thr Val Pro Ile Val Val Glu Asn Asn 
1               5                   10                  15      


Gly Arg Asn Glu Arg Ala Tyr Asp Ile Tyr Ser Arg Leu Leu Lys Asp 
            20                  25                  30          


Arg Ile Val Leu Leu Gly Thr Glu Val Asn Asp Gln Val Ala Ser Leu 
        35                  40                  45              


Ile Cys Ala Gln Leu Leu Phe Leu Glu Ser Gln Asp Pro Glu Lys Glu 
    50                  55                  60                  


Ile Tyr Leu Tyr Ile Asn Ser Pro Gly Gly Ser Val Thr Ala Gly Leu 
65                  70                  75                  80  


Ala Ile Tyr Asp Thr Met Asn Tyr Ile Thr Pro Asn Val Ala Thr Val 
                85                  90                  95      


Cys Met Gly Arg Ala Ala Ser Met Gly Ala Leu Leu Leu Ala Ala Gly 
            100                 105                 110         


Glu Lys Asn Met Arg Tyr Ala Leu Pro Asn Ser Gln Val Met Ile His 
        115                 120                 125             


Gln Pro Leu Gly Gly Tyr Gln Gly Gln Ala Thr Asp Ile Asp Ile His 
    130                 135                 140                 


Ala Arg Glu Ile Leu Arg Met Arg Gln Arg Leu Asn Glu Ile Leu Met 
145                 150                 155                 160 


Glu Gln Thr Gly Gln Ser Leu Glu Lys Val Ala Gln Asp Thr Glu Arg 
                165                 170                 175     


Asp Tyr Phe Met Thr Ala Glu Asp Ala Lys Ala Tyr Gly Leu Ile Asp 
            180                 185                 190         


Lys Val Leu Val Ser Arg Lys Asp Leu Asp Ile Glu His Glu Lys Thr 
        195                 200                 205             


Glu 
    


<210>  33
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cloned peptide

<400>  33

Met His His His His His His Gly Ser Glu Phe Met Asp Asp Ile Phe 
1               5                   10                  15      


Asn Met Thr Val Pro Ile Val Val Glu Asn Asn Gly Arg Asn Glu Arg 
            20                  25                  30          


Ala Tyr Asp Ile Tyr Ser Arg Leu Leu Lys Asp Arg Ile Val Leu Leu 
        35                  40                  45              


Gly Thr Glu Val Asn Asp Gln Val Ala Ser Leu Ile Cys Ala Gln Leu 
    50                  55                  60                  


Leu Phe Leu Glu Ser Gln Asp Pro Glu Lys Glu Ile Tyr Leu Tyr Ile 
65                  70                  75                  80  


Asn Ser Pro Gly Gly Ser Val Thr Ala Gly Leu Ala Ile Tyr Asp Thr 
                85                  90                  95      


Met Asn Tyr Ile Thr Pro Asn Val Ala Thr Val Cys Met Gly Arg Ala 
            100                 105                 110         


Ala Ser Met Gly Ala Leu Leu Leu Ala Ala Gly Glu Lys Asn Met Arg 
        115                 120                 125             


Tyr Ala Leu Pro Asn Ser Gln Val Met Ile His Gln Pro Leu Gly Gly 
    130                 135                 140                 


Tyr Gln Gly Gln Ala Thr Asp Ile Asp Ile His Ala Arg Glu Ile Leu 
145                 150                 155                 160 


Arg Met Arg Gln Arg Leu Asn Glu Ile Leu Met Glu Gln Thr Gly Gln 
                165                 170                 175     


Ser Leu Glu Lys Val Ala Gln Asp Thr Glu Arg Asp Tyr Phe Met Thr 
            180                 185                 190         


Ala Glu Asp Ala Lys Ala Tyr Gly Leu Ile Asp Lys Val Leu Val Ser 
        195                 200                 205             


Arg Lys Asp Leu Asp Ile Glu His Glu Lys Thr Glu 
    210                 215                 220 


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HH2

<400>  34

Val Gln Leu Arg Ile Arg Val Ala Val Ile Arg Ala 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1002

<400>  35

Val Gln Arg Trp Leu Ile Val Trp Arg Ile Arg Lys 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1018

<400>  36

Val Arg Leu Ile Val Ala Val Arg Ile Trp Arg Arg 
1               5                   10          


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Indolicidin

<400>  37

Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HH111

<400>  38

Ile Leu Lys Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HH113

<400>  39

Ile Leu Pro Trp Lys Lys Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HH970

<400>  40

Ile Leu Lys Trp Lys Trp Pro Trp Trp Lys Trp Arg Arg 
1               5                   10              


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HH1010

<400>  41

Ile Leu Arg Trp Lys Trp Arg Trp Trp Arg Trp Arg 
1               5                   10          


<210>  42
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nisin Z


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Dehydrobutyrine (Dhb)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = Dehydroalanine (Dha)
<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = 2-Aminobutyric acid (Abu)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = 2-Aminobutyric acid (Abu)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = 2-Aminobutyric acid (Abu)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = 2-Aminobutyric acid (Abu)

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa = Dehydroalanine (Dha)

<400>  42

Ile Xaa Ala Ile Xaa Leu Ala Xaa Pro Gly Ala Lys Xaa Gly Ala Leu 
1               5                   10                  15      


Met Gly Ala Asn Met Lys Xaa Ala Xaa Ala Asn Ala Ser Ile Asn Val 
            20                  25                  30          


Xaa Leu         


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JK1

<400>  43

Val Phe Leu Arg Arg Ile Arg Val Ile Val Ile Arg 
1               5                   10          


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JK2

<400>  44

Val Phe Trp Arg Arg Ile Arg Val Trp Val Ile 
1               5                   10      


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JK3

<400>  45

Val Gln Leu Arg Ala Ile Arg Val Arg Val Ile Arg 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JK4

<400>  46

Val Gln Leu Arg Arg Ile Arg Val Trp Val Ile Arg 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JK5

<400>  47

Val Gln Trp Arg Ala Ile Arg Val Arg Val Ile Arg 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JK6

<400>  48

Val Gln Trp Arg Arg Ile Arg Val Trp Val Ile Arg 
1               5                   10          


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG ODN 1826 

<400>  49
tccatgacgt tcctgacgtt                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG ODN 2007 

<400>  50
tccatgacgt tcctgacgtt                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CPG 7909 or 10103 

<400>  51
tccatgacgt tcctgacgtt                                                   20


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG 8954 

<400>  52
ggggacgacg tcgtgggggg g                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG 2395 or CpG 10101 

<400>  53
ggggacgacg tcgtgggggg g                                                 21


<210>  54
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Non-CPG ISS 

<400>  54
aaaaaaggta cctaaatagt atgtttctga aa                                     32


<210>  55
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  55
gacggatcct ctcttgtcat taataacaac ctgatgg                                37


<210>  56
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  56
gacggatcct ctcttgtcat taataacaac ctgatgg                                37


<210>  57
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  57
gagggatccg ctaatgttag tggaatccct gc                                     32


<210>  58
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  58
gagggatccg ctaatgttag tggaatccct gc                                     32


<210>  59
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  59
tcccatggct gaggctgttg aacactttg                                         29


<210>  60
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  60
ggctcgagtt agaatctata agtagctcct acc                                    33


<210>  61
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  61
cgccatggac agtgatgagg accttagtac ag                                     32


<210>  62
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  62
agctcgagta ggaatccacc actgatcaag                                        30


<210>  63
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  63
gagggatcca tgttgttata tataaataaa gaacacatta ttg                         43


<210>  64
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  64
gagctcgagt tatacttctt ctgtataata attttgttca                             40


<210>  65
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  65
gagggatcca tgttcaaaaa aatatatgtt ttttatatca c                           41


<210>  66
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  66
gagctcgagt tattcattag ggacaataat aggtgttac                              39


<210>  67
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  67
gagggatcca tgcatctata taatactatg gaaaag                                 36


<210>  68
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  68
gagctcgagt tataaaatat cccacacctg acc                                    33


<210>  69
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  69
gagctcgagt tataaaatat cccacacctg acc                                    33


<210>  70
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  70
cgcctcgagt tatattttta aagctgtttg taaatc                                 36


<210>  71
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  71
gagggatcca tggatatact acttcccttt gaaaaaagac                             40


<210>  72
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  72
gagggatcca tggatatact acttcccttt gaaaaaagac                             40


<210>  73
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  73
gagggatcca tggatatact acttcccttt gaaaaaagac                             40


<210>  74
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  74
gaaggcggcc gctagtacat accgtccata ccacc                                  35


<210>  75
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  75
gaggaattca tggatgatat ttttaatatg acagtc                                 36


<210>  76
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  76
gaggaattca tggatgatat ttttaatatg acagtc                                 36


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  77
ggttagtcgt tgcccatgat a                                                 21


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  78
ctgcgatatg ctcccatagt t                                                 21


