<110> Batalla, Milena; Panarum Corp.
<120> UNIVERSAL ORAL DELIVERY DEVICE OF INTACT THERAPEUTIC POLYPEPTIDES WITH HIGH BIOAVAILABILITY 
<130>
<140>
<141>
<150> 
<151> 
<160> 1
<170>
<210> 1
<211> 854
<212> PRT
<213> Artificial Sequence
<220>
<221>
<222>
<300>
<301>
<302>
<303>
<304>
<305>
<306>
<307>
<308>
<309> 
<400>
Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro
Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp 
Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Ala Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ala Ala Thr Thr Gly Tyr Asp Ala Val Asp Asp Leu Leu His Tyr His Glu Arg Gly Asn Ile Gln Ile Asn Gly Lys Asp Ser Phe Ser Asn Glu Gln Ala Gly Lys Phe Ile Thr Arg Glu Asn Gln Thr Trp Asn Gly Tyr Lys Val Phe Gly Gln Pro Val Lys Leu Thr Phe Ser Phe Pro Asp Tyr Lys Phe Ser Ser Thr Asn Val Ala Gly Asp Thr Gly Leu Ser Lys Phe Ser Ala Glu Gln Gln Gln Gln Ala Lys Leu Ser Leu Gln Ser Trp Ala Asp Val Ala Asn Ile Thr Phe Thr Glu Val Ala Ala Gly Gln Lys Ala Asn Ile Thr Phe Gly Asn Tyr Ser Gln Asp Arg Pro Gly His Tyr Asp Tyr Gly Thr Gln Ala Tyr Ala Phe Leu Pro Asn Thr Ile Trp Gln Gly Gln Asp Leu Gly Gly Gln Thr Trp Tyr Asn Val Asn Gln Ser Asn Val Lys His Pro Ala Thr Glu Asp Tyr Gly Arg Gln Thr Phe Thr His X Ile Gly His Ala Leu Gly Leu Ser His Pro Gly Asp Tyr Asn Ala Gly Glu Gly Asn Pro Thr Tyr Arg Asp Val Thr Tyr Ala Glu Asp Thr Arg Gln Phe Ser Leu Met Ser Tyr Trp Ser Glu Thr Asn Thr Gly Gly Asp Asn Gly Gly His Tyr Ala Ala Ala Pro Leu Leu Asp Asp Ile Ala Ala Ile Gln His Leu Tyr Gly Ala Asn Leu Ser Thr Arg Thr Gly Asp Thr Val tyr Gly Phe Asn Ser Asn Thr Gly Arg Asp Phe Leu Ser Thr Thr Ser Asn Ser Gln Lys Val Ile Phe Ala Ala Trp Asp Ala Gly Gly Asn Asp Thr Phe Asp Phe Ser Gly Tyr Thr Ala Asn Gln Arg Ile Asn Leu Asn Glu Lys Ser Phe Ser Asp Val Gly Gly Leu Lys Gly Asn Val Ser Ile Ala Ala Gly Val Thr Ile Glu Asn Ala Ile Gly Gly Ser Gly Asn Asp Val Ile Val Gly Asn Ala Ala Asn Asn Val Leu Lys Gly Gly Ala Gly Asn Asp Val Leu Phe Gly Gly Gly Gly Ala Asp Glu Leu Trp Gly Gly Ala Gly Lys Asp Ile Phe Val Phe Ser Ala Ala Ser Asp Ser Ala Pro Gly Ala Ser Asp Trp Ile Arg Asp Phe Gln Lys Gly Ile Asp Lys Ile Asp Leu Ser Phe Phe Asn Lys Glu Ala Gln Ser Ser Asp Phe Ile His Phe Val Asp His Phe Ser Gly Ala Ala Gly Glu Ala Leu Leu Ser Tyr Asn Ala Ser Asn Asn Val Thr Asp Leu Ser Val Asn Ile Gly Gly His Gln Ala Pro Asp Phe Leu Val Lys Ile Val Gly Gln Val Asp Val Ala Thr Asp Phe Ile Val



<110> Batalla, Milena; Panarum Corp.
<120> UNIVERSAL ORAL DELIVERY DEVICE OF INTACT THERAPEUTIC POLYPEPTIDES WITH HIGH BIOAVAILABILITY 
<130>
<140>
<141>
<150> US 62 809,687
<151> 2019-02-24
<160> 2
<170>
<210> 2
<211> 854
<212> PRT
<213> Artificial Sequence
<220>
<221>
<222>
<300>
<301>
<302>
<303>
<304>
<305>
<306>
<307>
<308>
<309> 
<400>
Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Ala Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ala Ala Thr Thr Gly Tyr Asp Ala Val Asp Asp Leu Leu His Tyr His Glu Arg Gly Asn Ile Gln Ile Asn Gly Lys Asp Ser Phe Ser Asn Glu Gln Ala Gly Lys Phe Ile Thr Arg Glu Asn Gln Thr Trp Asn Gly Tyr Lys Val Phe Gly Gln Pro Val Lys Leu Thr Phe Ser Phe Pro Asp Tyr Lys Phe Ser Ser Thr Asn Val Ala Gly Asp Thr Gly Leu Ser Lys Phe Ser Ala Glu Gln Gln Gln Gln Ala Lys Leu Ser Leu Gln Ser Trp Ala Asp Val Ala Asn Ile Thr Phe Thr Glu Val Ala Ala Gly Gln Lys Ala Asn Ile Thr Phe Gly Asn Tyr Ser Gln Asp Arg Pro Gly His Tyr Asp Tyr Gly Thr Gln Ala Tyr Ala Phe Leu Pro Asn Thr Ile Trp Gln Gly Gln Asp Leu Gly Gly Gln Thr Trp Tyr Asn Val Asn Gln Ser Asn Val Lys His Pro Ala Thr Glu Asp Tyr Gly Arg Gln Thr Phe Thr His X Ile Gly His Ala Leu Gly Leu Ser His Pro Gly Asp Tyr Asn Ala Gly Glu Gly Asn Pro Thr Tyr Arg Asp Val Thr Tyr Ala Glu Asp Thr Arg Gln Phe Ser Leu Met Ser Tyr Trp Ser Glu Thr Asn Thr Gly Gly Asp Asn Gly Gly His Tyr Ala Ala Ala Pro Leu Leu Asp Asp Ile Ala Ala Ile Gln His Leu Tyr Gly Ala Asn Leu Ser Thr Arg Thr Gly Asp Thr Val tyr Gly Phe Asn Ser Asn Thr Gly Arg Asp Phe Leu Ser Thr Thr Ser Asn Ser Gln Lys Val Ile Phe Ala Ala Trp Asp Ala Gly Gly Asn Asp Thr Phe Asp Phe Ser Gly Tyr Thr Ala Asn Gln Arg Ile Asn Leu Asn Glu Lys Ser Phe Ser Asp Val Gly Gly Leu Lys Gly Asn Val Ser Ile Ala Ala Gly Val Thr Ile Glu Asn Ala Ile Gly Gly Ser Gly Asn Asp Val Ile Val Gly Asn Ala Ala Asn Asn Val Leu Lys Gly Gly Ala Gly Asn Asp Val Leu Phe Gly Gly Gly Gly Ala Asp Glu Leu Trp Gly Gly Ala Gly Lys Asp Ile Phe Val Phe Ser Ala Ala Ser Asp Ser Ala Pro Gly Ala Ser Asp Trp Ile Arg Asp Phe Gln Lys Gly Ile Asp Lys Ile Asp Leu Ser Phe Phe Asn Lys Glu Ala Gln Ser Ser Asp Phe Ile His Phe Val Asp His Phe Ser Gly Ala Ala Gly Glu Ala Leu Leu Ser Tyr Asn Ala Ser Asn Asn Val Thr Asp Leu Ser Val Asn Ile Gly Gly His Gln Ala Pro Asp Phe Leu Val Lys Ile Val Gly Gln Val Asp Val Ala Thr Asp Phe Ile Val



<110> Batalla, Milena; Panarum Corp.
<120> UNIVERSAL ORAL DELIVERY DEVICE OF INTACT THERAPEUTIC POLYPEPTIDES WITH HIGH BIOAVAILABILITY 
<130>
<140>
<141>
<150> 
<151> 
<160> 3
<170>
<210> 3
<211> 2580
<212> DNA
<213> Artificial Sequence
<220>
<221>
<222>
<300>
<301>
<302>
<303>
<304>
<305>
<306>
<307>
<308>
<309> 
<400>
aagcttatga aaatcgaaga aggtaaactg gtaatctgga ttaacggcga taaaggctat aacggtctcg ctgaagtcgg taagaaattc gagaaagata ccggaattaa agtcaccgtt gagcatccgg ataaactgga agagaaattc ccacaggttg cggcaactgg cgatggccct gacattatct tctgggcaca cgaccgcttt ggtggctacg ctcaatctgg cctgttggct gaaatcaccc cggacaaagc gttccaggac aagctgtatc cgtttacctg ggatgccgta cgttacaacg gcaagctgat tgcttacccg atcgctgttg aagcgttatc gctgatttat aacaaagatc tgctgccgaa cccgccaaaa acctgggaag agatcccggc gctggataaa gaactgaaag cgaaaggtaa gagcgcgctg atgttcaacc tgcaagaacc gtacttcacc tggccgctga ttgctgctga cgggggttat gcgttcaagt atgaaaacgg caagtacgac attaaagacg tgggcgtgga taacgctggc gcgaaagcgg gtctgacctt cctggttgac ctgattaaaa acaaacacat gaatgcagac accgattact ccatcgcaga agctgccttt aataaaggcg aaacagcgat gaccatcaac ggcccgtggg catggtccaa catcgacacc agcaaagtga attatggtgt aacggtactg ccgaccttca agggtcaacc atccaaaccg ttcgttggcg tgctgagcgc aggtattaac gccgccagtc cgaacaaaga gctggcaaaa gagttcctcg aaaactatct gctgactgat gaaggtctgg aagcggttaa taaagacaaa ccgctgggtg ccgtagcgct gaagtcttac gaggaagagt tggtgaaaga tccgcgtatt gccgccacta tggaaaacgc ccagaaaggt gaaatcatgc cgaacatccc gcagatgtcc gctttctggt atgccgtgcg tactgcggtg atcaacgccg ccagcggtcg tcagactgtc gatgaagccc tgaaagacgc gcagactaat tcgagctcga acaacaacaa caataacaat aacaacaacc tgggtgcggc gaccaccggc tacgacgcgg ttgacgacct gctgcactac cacgaacgcg gcaatggcat ccaaattaac ggcaaagata gcttcagcaa cgagcaggcg ggtctgttta tcacccgtga aaaccaaacc tggaacggtt acaaggtgtt tggccagccg gttaaactga ccttcagctt tccggactat aagttcagca gcaccaacgt ggcgggtgat accggcctga gcaagtttag cgcggagcag caacagcaag cgaaactgag cctgcagagc tgggcggatg tggcgaacat caccttcacc gaagttgcgg cgggtcaaaa agcgaacatt acctttggca actacagcca ggaccgtccg ggtcactacg attatggcac ccaagcgtat gcgttcctgc cgaacaccat ctggcagggt caagacctgg gtggccagac ctggtacaac gtgaaccaaa gcaacgttaa gcacccggcg accgaggatt atggtcgtca gacctttacc cacgcgattg gtcatgcgct gggcctgagc catccgggtg actacaacgc gggcgagggc aacccgacct accgtgacgt gacctatgcg gaagataccc gtcagttcag cctgatgagc tactggagcg aaaccaacac cggtggcgat aacggtggcc actatgcggc ggcgccgctg ctggatgata ttgcggcgat tcaacacctg tacggtgcga acctgagcac ccgtaccggt gacaccgtgt atggcttcaa cagcaacacc ggtcgtgatt ttctgagcac caccagcaac agccagaaag ttatctttgc ggcgtgggat gcgggtggca acgacacctt cgattttagc ggttataccg cgaaccaacg tattaacctg aacgagaaga gctttagcga tgttggtggc ctgaagggta acgtgagcat cgcggcgggc gttaccatcg aaaacgcgat tggtggcagc ggtaacgacg tgattgttgg caacgcggcg aacaacgtgc tgaagggtgg cgcgggtaac gacgttctgt tcggtggcgg tggcgcggat gagctgtggg gtggcgcggg taaagacatc ttcgtgttta gcgcggcgag cgatagcgcg ccgggtgcga gcgactggat tcgtgatttc cagaagggca tcgacaaaat tgatctgagc ttctttaaca aagaggcgca aagcagcgac ttcatccact ttgttgatca ctttagcggt gcggcgggtg aagcgctgct gagctacaac gcgagcaaca acgtgaccga cctgagcgtt aacattggtg gccaccaggc gccggatttt ctggtgaaga ttgtgggcca agtggatgtt gcgaccgatt ttattgtgta atgactcgag





