                         SEQUENCE LISTING

<110>  ARBELE Limited
 
<120>  ARTIFICIAL IMMUNOSURVEILLANCE CHIMERIC ANTIGEN RECEPTOR (AI-CAR) 
       AND CELLS EXPRESSING THE SAME

<130>  ARTI917PCT

<150>  62/808,815
<151>  2019-02-21

<150>  .62/808,823
<151>  2019-02-21

<150>  62/808,833
<151>  2019-02-21

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  1

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Phe Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Arg Val Asn Pro Ser Asn Gly Asp Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Arg Ile Tyr Tyr Gly Ile Ser Trp Tyr Phe 
        115                 120                 125             


Asp Val Trp Asp Thr Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu Tyr Asn Ala Lys 
        195                 200                 205             


Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys His His Tyr Tyr Ser Thr Pro Pro Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ala Val Val Ile Ser Val Gly Ser Met 
305                 310                 315                 320 


Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr 
                325                 330                 335     


Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu 
            340                 345                 350         


Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala 
        355                 360                 365             


Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu 
    370                 375                 380                 


Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro 
385                 390                 395                 400 


Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys 
                405                 410                 415     


Pro Glu Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            420                 425                 430         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        435                 440                 445             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    450                 455                 460                 


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             


Leu Pro Pro Arg 
    530         


<210>  2
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  2

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ser Ile Ser Phe Asp Gly Thr Tyr Thr Tyr Tyr Thr 
65                  70                  75                  80  


Asp Arg Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Arg Pro Ala Trp Phe Pro Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Asp Ile Val Met Thr Gln Thr Pro 
145                 150                 155                 160 


Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg 
                165                 170                 175     


Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp 
            180                 185                 190         


Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val 
        195                 200                 205             


Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 
225                 230                 235                 240 


Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Leu Lys Gly Ala Pro Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Pro Trp Leu Gly His Leu Leu 
305                 310                 315                 320 


Val Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu 
                325                 330                 335     


Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys 
            340                 345                 350         


Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His 
        355                 360                 365             


Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser 
    370                 375                 380                 


Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu 
385                 390                 395                 400 


Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro 
                405                 410                 415     


Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr 
            420                 425                 430         


Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu 
        435                 440                 445             


Ala Cys Gln Val Tyr Phe Arg Ser Lys Arg Ser Arg Gly Gly His Ser 
    450                 455                 460                 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
465                 470                 475                 480 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro 
                485                 490                 495     


<210>  3
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  3

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
        35                  40                  45              


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gly Ala Pro Lys Leu Leu Ile Tyr His Thr Ser Arg Leu 
        195                 200                 205             


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Ala Asp Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
305                 310                 315                 320 


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
                325                 330                 335     


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
            340                 345                 350         


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
        355                 360                 365             


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
    370                 375                 380                 


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
385                 390                 395                 400 


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
                405                 410                 415     


Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            420                 425                 430         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        435                 440                 445             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    450                 455                 460                 


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
465                 470                 475                 480 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                485                 490                 495     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            500                 505                 510         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        515                 520                 525             


Pro Arg 
    530 


<210>  4
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  4

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Met Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe Val Met Asp Ser Trp 
        115                 120                 125             


Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu 
        195                 200                 205             


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Ala Asp Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe 
305                 310                 315                 320 


Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg 
                325                 330                 335     


Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu 
            340                 345                 350         


Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn 
        355                 360                 365             


Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln 
    370                 375                 380                 


Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
385                 390                 395                 400 


Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro 
                405                 410                 415     


Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg 
            420                 425                 430         


Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala 
        435                 440                 445             


Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys 
    450                 455                 460                 


Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr 
465                 470                 475                 480 


Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr 
                485                 490                 495     


Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser 
            500                 505                 510         


Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
        515                 520                 525             


<210>  5
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  5

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ser Ser Ser Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Arg Ile Tyr Ser Gly Asp Gly Asp Ala Ile Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Lys Thr Gly Asp Leu Leu Leu Arg Ser 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn 
                165                 170                 175     


Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ile Tyr Ser Tyr Met His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr 
        195                 200                 205             


Ala Ser Tyr Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
225                 230                 235                 240 


Val Ala Val Tyr Tyr Cys Glu His Ser Arg Glu Phe Pro Phe Thr Phe 
                245                 250                 255     


Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ala Pro Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Ala Asp Pro Ile Leu Leu Thr Ile Ser 
305                 310                 315                 320 


Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val 
                325                 330                 335     


Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp 
            340                 345                 350         


His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu 
        355                 360                 365             


Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg 
    370                 375                 380                 


Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
385                 390                 395                 400 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
                405                 410                 415     


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
            420                 425                 430         


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
        435                 440                 445             


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
    450                 455                 460                 


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
465                 470                 475                 480 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
                485                 490                 495     


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
            500                 505                 510         


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
        515                 520                 525             


Phe Tyr Gln Asn Gln 
    530             


<210>  6
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  6

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe 
        35                  40                  45              


Ser Ile Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg His Ser Gly Tyr Gly Ser Ser Tyr Gly Val Leu 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser 
        195                 200                 205             


Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Ala Asp Ile Pro Trp Leu Gly His Leu Leu Val 
305                 310                 315                 320 


Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile 
                325                 330                 335     


Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
            340                 345                 350         


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
        355                 360                 365             


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
    370                 375                 380                 


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
385                 390                 395                 400 


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
                405                 410                 415     


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
            420                 425                 430         


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
        435                 440                 445             


Cys Gln Val Tyr Phe Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp 
    450                 455                 460                 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
465                 470                 475                 480 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Pro 
                485                 490                 495 


<210>  7
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  7

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu 
        35                  40                  45              


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gly Ala Pro Lys Leu Leu Ile Tyr His Thr Ser Arg Leu 
        195                 200                 205             


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Ala Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe 
305                 310                 315                 320 


Leu Ser Ile Leu Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg 
                325                 330                 335     


Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser 
            340                 345                 350         


Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro 
        355                 360                 365             


Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu 
    370                 375                 380                 


Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu 
385                 390                 395                 400 


Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu 
                405                 410                 415     


Glu Asp Gly Asp Arg Cys Lys Ala Lys Met Lys Arg Gly Arg Lys Lys 
            420                 425                 430         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        435                 440                 445             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    450                 455                 460                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
465                 470                 475                 480 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                485                 490                 495     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            500                 505                 510         


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        515                 520                 525             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    530                 535                 540                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
545                 550                 555                 560 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                565                 570                 575     


Ala Leu Pro Pro Arg 
            580     


<210>  8
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  8

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Met Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe Val Met Asp Ser Trp 
        115                 120                 125             


Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu 
        195                 200                 205             


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Ala Asp Trp Met Ala Phe Val Ala Pro Ser Ile Cys Ile Ala 
305                 310                 315                 320 


Ile Ile Met Val Gly Ile Phe Ser Thr His Tyr Phe Gln Gln Lys Val 
                325                 330                 335     


Phe Val Leu Leu Ala Ala Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile 
            340                 345                 350         


Pro Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu 
        355                 360                 365             


Glu Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr 
    370                 375                 380                 


Pro Glu Asp Pro Glu Pro Leu Val Ile Ser Glu Val Leu His Gln Val 
385                 390                 395                 400 


Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu 
                405                 410                 415     


Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp Met Met His Ser 
            420                 425                 430         


Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln 
        435                 440                 445             


Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly Ser Asp Pro Lys 
    450                 455                 460                 


Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu 
465                 470                 475                 480 


Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser 
                485                 490                 495     


His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln His 
            500                 505                 510         


Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His Pro Leu Thr Phe 
        515                 520                 525             


Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys Met Arg Cys Asp 
    530                 535                 540                 


Ser Leu Met Leu 
545             


<210>  9
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  9

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Ala Tyr Ala Phe 
        35                  40                  45              


Ser Ser Ser Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Arg Ile Tyr Pro Arg Asp Gly Asp Thr Asn Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Asp Gly Tyr Tyr Trp Tyr Phe Asp Val 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Arg Asn Tyr Leu His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Glu Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Gln Ser 
        195                 200                 205             


Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Glu Thr Glu Asp Phe Ala Met Tyr 
225                 230                 235                 240 


Tyr Cys Gln His Ser Asn Ser Trp Pro Leu Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Ala Asp Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
305                 310                 315                 320 


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
                325                 330                 335     


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
            340                 345                 350         


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
        355                 360                 365             


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
    370                 375                 380                 


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
385                 390                 395                 400 


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
                405                 410                 415     


Thr Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            420                 425                 430         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        435                 440                 445             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    450                 455                 460                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
465                 470                 475                 480 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                485                 490                 495     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
            500                 505                 510         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        515                 520                 525             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    530                 535                 540                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
545                 550                 555                 560 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                565                 570         


<210>  10
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  10

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Asp Ser Asn Gly Gly Ser Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Ser Tyr Thr Asn Leu Gly Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Asp Ile Ser Gly Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gly 
            180                 185                 190         


Ala Ile Lys Arg Leu Ile Tyr Thr Thr Ser Thr Leu Asp Ser Gly Val 
        195                 200                 205             


Pro Lys Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
225                 230                 235                 240 


Tyr Ala Ser Ser Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys Gly Ala Pro Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Ala Asp Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val 
305                 310                 315                 320 


Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys 
                325                 330                 335     


Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His 
            340                 345                 350         


Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu 
        355                 360                 365             


Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg 
    370                 375                 380                 


Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu 
385                 390                 395                 400 


Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys 
                405                 410                 415     


Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser 
            420                 425                 430         


Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile 
        435                 440                 445             


Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly 
    450                 455                 460                 


Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser 
465                 470                 475                 480 


Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn 
                485                 490                 495     


Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln 
            500                 505                 510         


Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
        515                 520                 525     


<210>  11
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  11

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Asp Ser Asn Gly Gly Ser Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Ser Tyr Thr Asn Leu Gly Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Asp Ile Ser Gly Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gly 
            180                 185                 190         


Ala Ile Lys Arg Leu Ile Tyr Thr Thr Ser Thr Leu Asp Ser Gly Val 
        195                 200                 205             


Pro Lys Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
225                 230                 235                 240 


Tyr Ala Ser Ser Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Phe Gly 
            500                 505                 510         


Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly Val Gln Cys Tyr 
        515                 520                 525             


Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn Asp 
    530                 535                 540                 


Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp Met 
545                 550                 555                 560 


Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile Ile 
                565                 570                 575     


Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile Ser 
            580                 585                 590         


Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile Ile 
        595                 600                 605             


Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys Ser 
    610                 615                 620                 


Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys Met 
625                 630                 635                 640 


Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu Lys 
                645                 650                 655     


Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu Gly 
            660                 665                 670         


Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
        675                 680                 


<210>  12
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  12

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Asp Ser Asn Gly Gly Ser Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Ser Tyr Thr Asn Leu Gly Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Asp Ile Ser Gly Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gly 
            180                 185                 190         


Ala Ile Lys Arg Leu Ile Tyr Thr Thr Ser Thr Leu Asp Ser Gly Val 
        195                 200                 205             


Pro Lys Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
225                 230                 235                 240 


Tyr Ala Ser Ser Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys His Leu 
            500                 505                 510         


Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp Val Leu Ser Gln 
        515                 520                 525             


Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn Ala 
    530                 535                 540                 


Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile Leu 
545                 550                 555                 560 


Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln Ile 
                565                 570                 575     


Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln Ser 
            580                 585                 590         


Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val Lys Phe 
        595                 600                 605             


Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr Asn 
    610                 615                 620                 


Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu Leu 
625                 630                 635                 640 


Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Lys Arg 
                645                 650                 655     


Lys Arg Ser Gln Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
            660                 665                 670 


<210>  13
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  13

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Asp Ser Asn Gly Gly Ser Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Ser Tyr Thr Asn Leu Gly Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Asp Ile Ser Gly Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gly 
            180                 185                 190         


Ala Ile Lys Arg Leu Ile Tyr Thr Thr Ser Thr Leu Asp Ser Gly Val 
        195                 200                 205             


Pro Lys Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
225                 230                 235                 240 


Tyr Ala Ser Ser Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Phe Gly 
            500                 505                 510         


Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly Val Gln Cys Tyr 
        515                 520                 525             


Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn Asp 
    530                 535                 540                 


Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp Met 
545                 550                 555                 560 


Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile Ile 
                565                 570                 575     


Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile Ser 
            580                 585                 590         


Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile Ile 
        595                 600                 605             


Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys Ser 
    610                 615                 620                 


Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys Met 
625                 630                 635                 640 


Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu Lys 
                645                 650                 655     


Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu Gly 
            660                 665                 670         


Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Pro Ala Gly Gly 
        675                 680                 685             


Gly Thr Lys Thr Glu Ser Ser Ser Arg Ser Asp Gly Gly Ala Gln Asp 
    690                 695                 700                 


Cys Cys Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala Lys Val Val Arg 
705                 710                 715                 720 


Ser Tyr Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser Ile Pro Ala Ile 
                725                 730                 735     


Leu Phe Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu Cys Ala Asp Pro 
            740                 745                 750         


Lys Glu Leu Trp Val Gln Gln Leu Met Gln His Leu Asp Lys Thr Pro 
        755                 760                 765             


Ser Pro Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp Arg Gly Ala Ser 
    770                 775                 780                 


Lys Thr Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg Thr Glu 
785                 790                 795                 800 


Arg Ser Gln Thr Pro Lys Gly Pro 
                805             


<210>  14
<211>  1119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  14

Tyr Tyr Pro Asp Thr Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys Ser Ser Tyr Thr Asn Leu Gly Ala Tyr Trp 
        35                  40                  45              


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
65                  70                  75                  80  


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                85                  90                  95      


Arg Ala Ser Gln Asp Ile Ser Gly Tyr Leu Asn Trp Leu Gln Gln Lys 
            100                 105                 110         


Pro Gly Gly Ala Ile Lys Arg Leu Ile Tyr Thr Thr Ser Thr Leu Asp 
        115                 120                 125             


Ser Gly Val Pro Lys Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    130                 135                 140                 


Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr 
145                 150                 155                 160 


Cys Leu Gln Tyr Ala Ser Ser Pro Phe Thr Phe Gly Gly Gly Thr Lys 
                165                 170                 175     


Val Glu Ile Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            180                 185                 190         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        195                 200                 205             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    210                 215                 220                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
225                 230                 235                 240 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                245                 250                 255     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            260                 265                 270         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        275                 280                 285             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    290                 295                 300                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
305                 310                 315                 320 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                325                 330                 335     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            340                 345                 350         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        355                 360                 365             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    370                 375                 380                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
385                 390                 395                 400 


Met Gln Ala Leu Pro Pro Arg Ala Ser Gly Ser Gly Ala Thr Asn Phe 
                405                 410                 415     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            420                 425                 430         


Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly Val 
        435                 440                 445             


Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    450                 455                 460                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
465                 470                 475                 480 


Thr Tyr Thr Met Ser Trp Val Arg Gln Thr Pro Ala Lys Gly Leu Val 
                485                 490                 495     


Trp Val Ser Thr Ile Asn Ser Asp Gly Tyr Asn Ile Tyr Tyr Ser Asp 
            500                 505                 510         


Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Tyr Thr 
        515                 520                 525             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr 
    530                 535                 540                 


Tyr Cys Ala Arg Cys Ser Tyr Tyr Ser Tyr Asp Tyr Phe Asp Tyr Trp 
545                 550                 555                 560 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
            580                 585                 590         


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
        595                 600                 605             


Arg Ala Ser Glu Asn Ile Asp Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    610                 615                 620                 


Gln Gly Lys Val Pro Lys Leu Leu Ile Tyr Ala Ala Thr Asn Leu Ala 
625                 630                 635                 640 


Asp Gly Met Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                645                 650                 655     


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr 
            660                 665                 670         


Cys Gln His Tyr Tyr Ser Asn Gln Leu Thr Phe Gly Gln Gly Thr Lys 
        675                 680                 685             


Leu Glu Ile Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    690                 695                 700                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
705                 710                 715                 720 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                725                 730                 735     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            740                 745                 750         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
        755                 760                 765             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    770                 775                 780                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
785                 790                 795                 800 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                805                 810                 815     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            820                 825                 830         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        835                 840                 845             


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
    850                 855                 860                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
865                 870                 875                 880 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                885                 890                 895     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            900                 905                 910         


Met Gln Ala Leu Pro Pro Arg Ala Ser Gly Ser Gly Ala Thr Asn Phe 
        915                 920                 925             


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
    930                 935                 940                 


Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly Val 
945                 950                 955                 960 


Gln Cys Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn 
                965                 970                 975     


Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe 
            980                 985                 990         


Glu Asp Met Thr Asp Ser Asp Cys  Arg Asp Asn Ala Pro  Arg Thr Ile 
        995                 1000                 1005             


Phe Ile  Ile Ser Met Tyr Lys  Asp Ser Gln Pro Arg  Gly Met Ala 
    1010                 1015                 1020             


Val Thr  Ile Ser Val Lys Cys  Glu Lys Ile Ser Thr  Leu Ser Cys 
    1025                 1030                 1035             


Glu Asn  Lys Ile Ile Ser Phe  Lys Glu Met Asn Pro  Pro Asp Asn 
    1040                 1045                 1050             


Ile Lys  Asp Thr Lys Ser Asp  Ile Ile Phe Phe Gln  Arg Ser Val 
    1055                 1060                 1065             


Pro Gly  His Asp Asn Lys Met  Gln Phe Glu Ser Ser  Ser Tyr Glu 
    1070                 1075                 1080             


Gly Tyr  Phe Leu Ala Cys Glu  Lys Glu Arg Asp Leu  Phe Lys Leu 
    1085                 1090                 1095             


Ile Leu  Lys Lys Glu Asp Glu  Leu Gly Asp Arg Ser  Ile Met Phe 
    1100                 1105                 1110             


Thr Val  Gln Asn Glu Asp 
    1115                 


<210>  15
<211>  1024
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  15

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Asp Ser Asn Gly Gly Ser Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Ser Tyr Thr Asn Leu Gly Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Asp Ile Ser Gly Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gly 
            180                 185                 190         


Ala Ile Lys Arg Leu Ile Tyr Thr Thr Ser Thr Leu Asp Ser Gly Val 
        195                 200                 205             


Pro Lys Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
225                 230                 235                 240 


Tyr Ala Ser Ser Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Phe Gly 
            500                 505                 510         


Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly Val Gln Cys Gln 
        515                 520                 525             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
    530                 535                 540                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr 
545                 550                 555                 560 


Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                565                 570                 575     


Ser Ile Ser Phe Asp Gly Thr Tyr Thr Tyr Tyr Thr Asp Arg Val Lys 
            580                 585                 590         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        595                 600                 605             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    610                 615                 620                 


Arg Asp Arg Pro Ala Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
625                 630                 635                 640 


Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            660                 665                 670         


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        675                 680                 685             


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    690                 695                 700                 


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
705                 710                 715                 720 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                725                 730                 735     


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            740                 745                 750         


Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        755                 760                 765             


Leu Glu Leu Lys Pro Ala Gly Gly Gly Gly Gly Ser Glu Val Gln Leu 
    770                 775                 780                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
785                 790                 795                 800 


Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp 
                805                 810                 815     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn 
            820                 825                 830         


Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
        835                 840                 845             


Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
    850                 855                 860                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly 
865                 870                 875                 880 


Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
                885                 890                 895     


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            900                 905                 910         


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
        915                 920                 925             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
    930                 935                 940                 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
945                 950                 955                 960 


Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro 
                965                 970                 975     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
            980                 985                 990         


Ser Ser Leu Gln Pro Glu Asp Phe  Ala Thr Tyr Tyr Cys  Gln Gln Gly 
        995                 1000                 1005             


Asn Thr  Leu Pro Trp Thr Phe  Gly Gln Gly Thr Lys  Val Glu Ile 
    1010                 1015                 1020             


Lys 
    


<210>  16
<211>  1195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  16

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Asp Ser Asn Gly Gly Ser Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Ser Tyr Thr Asn Leu Gly Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Asp Ile Ser Gly Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gly 
            180                 185                 190         


Ala Ile Lys Arg Leu Ile Tyr Thr Thr Ser Thr Leu Asp Ser Gly Val 
        195                 200                 205             


Pro Lys Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
225                 230                 235                 240 


Tyr Ala Ser Ser Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Phe Gly 
            500                 505                 510         


Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly Val Gln Cys Gln 
        515                 520                 525             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
    530                 535                 540                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr 
545                 550                 555                 560 


Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                565                 570                 575     


Ser Ile Ser Phe Asp Gly Thr Tyr Thr Tyr Tyr Thr Asp Arg Val Lys 
            580                 585                 590         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        595                 600                 605             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    610                 615                 620                 


Arg Asp Arg Pro Ala Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
625                 630                 635                 640 


Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            660                 665                 670         


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        675                 680                 685             


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    690                 695                 700                 


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
705                 710                 715                 720 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                725                 730                 735     


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            740                 745                 750         


Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        755                 760                 765             


Leu Glu Leu Lys Pro Ala Gly Gly Gly Gly Gly Ser Glu Val Gln Leu 
    770                 775                 780                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
785                 790                 795                 800 


Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp 
                805                 810                 815     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn 
            820                 825                 830         


Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
        835                 840                 845             


Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
    850                 855                 860                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly 
865                 870                 875                 880 


Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
                885                 890                 895     


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            900                 905                 910         


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
        915                 920                 925             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
    930                 935                 940                 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
945                 950                 955                 960 


Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro 
                965                 970                 975     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
            980                 985                 990         


Ser Ser Leu Gln Pro Glu Asp Phe  Ala Thr Tyr Tyr Cys  Gln Gln Gly 
        995                 1000                 1005             


Asn Thr  Leu Pro Trp Thr Phe  Gly Gln Gly Thr Lys  Val Glu Ile 
    1010                 1015                 1020             


Lys Pro  Ala Gly Gly Gly Thr  Lys Thr Glu Ser Ser  Ser Arg Gly 
    1025                 1030                 1035             


Tyr Phe  Gly Lys Leu Glu Ser  Lys Leu Ser Val Ile  Arg Asn Leu 
    1040                 1045                 1050             


Asn Asp  Gln Val Leu Phe Ile  Asp Gln Gly Asn Arg  Pro Leu Phe 
    1055                 1060                 1065             


Glu Asp  Met Thr Asp Ser Asp  Cys Arg Asp Asn Ala  Pro Arg Thr 
    1070                 1075                 1080             


Ile Phe  Ile Ile Ser Met Tyr  Lys Asp Ser Gln Pro  Arg Gly Met 
    1085                 1090                 1095             


Ala Val  Thr Ile Ser Val Lys  Cys Glu Lys Ile Ser  Thr Leu Ser 
    1100                 1105                 1110             


Cys Glu  Asn Lys Ile Ile Ser  Phe Lys Glu Met Asn  Pro Pro Asp 
    1115                 1120                 1125             


Asn Ile  Lys Asp Thr Lys Ser  Asp Ile Ile Phe Phe  Gln Arg Ser 
    1130                 1135                 1140             


Val Pro  Gly His Asp Asn Lys  Met Gln Phe Glu Ser  Ser Ser Tyr 
    1145                 1150                 1155             


Glu Gly  Tyr Phe Leu Ala Cys  Glu Lys Glu Arg Asp  Leu Phe Lys 
    1160                 1165                 1170             


Leu Ile  Leu Lys Lys Glu Asp  Glu Leu Gly Asp Arg  Ser Ile Met 
    1175                 1180                 1185             


Phe Thr  Val Gln Asn Glu Asp  
    1190                 1195 


<210>  17
<211>  1301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  17

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Asp Ser Asn Gly Gly Ser Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Ser Tyr Thr Asn Leu Gly Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Asp Ile Ser Gly Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Gly 
            180                 185                 190         


Ala Ile Lys Arg Leu Ile Tyr Thr Thr Ser Thr Leu Asp Ser Gly Val 
        195                 200                 205             


Pro Lys Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
225                 230                 235                 240 


Tyr Ala Ser Ser Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys Gly Ala Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Phe Gly 
            500                 505                 510         


Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly Val Gln Cys Gln 
        515                 520                 525             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
    530                 535                 540                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr 
545                 550                 555                 560 


Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                565                 570                 575     


Ser Ile Ser Phe Asp Gly Thr Tyr Thr Tyr Tyr Thr Asp Arg Val Lys 
            580                 585                 590         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        595                 600                 605             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    610                 615                 620                 


Arg Asp Arg Pro Ala Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
625                 630                 635                 640 


Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            660                 665                 670         


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        675                 680                 685             


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    690                 695                 700                 


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
705                 710                 715                 720 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                725                 730                 735     


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            740                 745                 750         


Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        755                 760                 765             


Leu Glu Leu Lys Pro Ala Gly Gly Gly Gly Gly Ser Glu Val Gln Leu 
    770                 775                 780                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
785                 790                 795                 800 


Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp 
                805                 810                 815     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn 
            820                 825                 830         


Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
        835                 840                 845             


Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
    850                 855                 860                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly 
865                 870                 875                 880 


Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
                885                 890                 895     


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            900                 905                 910         


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
        915                 920                 925             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
    930                 935                 940                 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
945                 950                 955                 960 


Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro 
                965                 970                 975     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
            980                 985                 990         


Ser Ser Leu Gln Pro Glu Asp Phe  Ala Thr Tyr Tyr Cys  Gln Gln Gly 
        995                 1000                 1005             


Asn Thr  Leu Pro Trp Thr Phe  Gly Gln Gly Thr Lys  Val Glu Ile 
    1010                 1015                 1020             


Lys Pro  Ala Gly Gly Gly Thr  Lys Thr Glu Ser Ser  Ser Arg Gly 
    1025                 1030                 1035             


Tyr Phe  Gly Lys Leu Glu Ser  Lys Leu Ser Val Ile  Arg Asn Leu 
    1040                 1045                 1050             


Asn Asp  Gln Val Leu Phe Ile  Asp Gln Gly Asn Arg  Pro Leu Phe 
    1055                 1060                 1065             


Glu Asp  Met Thr Asp Ser Asp  Cys Arg Asp Asn Ala  Pro Arg Thr 
    1070                 1075                 1080             


Ile Phe  Ile Ile Ser Met Tyr  Lys Asp Ser Gln Pro  Arg Gly Met 
    1085                 1090                 1095             


Ala Val  Thr Ile Ser Val Lys  Cys Glu Lys Ile Ser  Thr Leu Ser 
    1100                 1105                 1110             


Cys Glu  Asn Lys Ile Ile Ser  Phe Lys Glu Met Asn  Pro Pro Asp 
    1115                 1120                 1125             


Asn Ile  Lys Asp Thr Lys Ser  Asp Ile Ile Phe Phe  Gln Arg Ser 
    1130                 1135                 1140             


Val Pro  Gly His Asp Asn Lys  Met Gln Phe Glu Ser  Ser Ser Tyr 
    1145                 1150                 1155             


Glu Gly  Tyr Phe Leu Ala Cys  Glu Lys Glu Arg Asp  Leu Phe Lys 
    1160                 1165                 1170             


Leu Ile  Leu Lys Lys Glu Asp  Glu Leu Gly Asp Arg  Ser Ile Met 
    1175                 1180                 1185             


Phe Thr  Val Gln Asn Glu Asp  Ser Gly Gly Gly Thr  Lys Thr Glu 
    1190                 1195                 1200             


Ser Ser  Ser Arg Gly Val Gly  Ser Glu Val Ser Asp  Lys Arg Thr 
    1205                 1210                 1215             


Cys Val  Ser Leu Thr Thr Gln  Arg Leu Pro Val Ser  Arg Ile Lys 
    1220                 1225                 1230             


Thr Tyr  Thr Ile Thr Glu Gly  Ser Leu Arg Ala Val  Ile Phe Ile 
    1235                 1240                 1245             


Thr Lys  Arg Gly Leu Lys Val  Cys Ala Asp Pro Gln  Ala Thr Trp 
    1250                 1255                 1260             


Val Arg  Asp Val Val Arg Ser  Met Asp Arg Lys Ser  Asn Thr Arg 
    1265                 1270                 1275             


Asn Asn  Met Ile Gln Thr Lys  Pro Thr Gly Thr Gln  Gln Ser Thr 
    1280                 1285                 1290             


Asn Thr  Ala Val Thr Leu Thr  Gly 
    1295                 1300     


<210>  18
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  18

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ser Ile Ser Phe Asp Gly Thr Tyr Thr Tyr Tyr Thr 
65                  70                  75                  80  


Asp Arg Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Arg Pro Ala Trp Phe Pro Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Asp Ile Val Met Thr Gln Thr Pro 
145                 150                 155                 160 


Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg 
                165                 170                 175     


Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp 
            180                 185                 190         


Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val 
        195                 200                 205             


Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 
225                 230                 235                 240 


Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Leu Lys Pro Ala Gly Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
    290                 295                 300                 


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
                325                 330                 335     


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
    370                 375                 380                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
                405                 410                 415     


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
            420                 425                 430         


Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
        435                 440                 445             


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu 
    450                 455                 460                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
465                 470                 475                 480 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
                485                 490                 495     


Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys 
            500                 505                 510         


Val Glu Ile Lys Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        515                 520                 525             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Phe Gly 
    530                 535                 540                 


Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly Val Gln Cys Tyr 
545                 550                 555                 560 


Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn Asp 
                565                 570                 575     


Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp Met 
            580                 585                 590         


Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile Ile 
        595                 600                 605             


Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile Ser 
    610                 615                 620                 


Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile Ile 
625                 630                 635                 640 


Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys Ser 
                645                 650                 655     


Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys Met 
            660                 665                 670         


Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu Lys 
        675                 680                 685             


Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu Gly 
    690                 695                 700                 


Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
705                 710                 715     


<210>  19
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  19

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Ser Gly Gly Gly Ser Gly Ala Pro Thr Thr Thr Pro 
            180                 185                 190         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        195                 200                 205             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    210                 215                 220                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
225                 230                 235                 240 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                245                 250                 255     


Cys Lys Lys Pro Ala Gly Arg Asn Thr Gly Pro Trp Leu Lys Lys Val 
            260                 265                 270         


Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser 
        275                 280                 285             


Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro 
    290                 295                 300                 


Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu 
305                 310                 315                 320 


Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Asn Thr Asp 
                325                 330                 335     


Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
            340                 345                 


<210>  20
<211>  818
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  20

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Ser Gly Gly Gly Ser Gly Ala Pro Thr Thr Thr Pro 
            180                 185                 190         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        195                 200                 205             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    210                 215                 220                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
225                 230                 235                 240 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                245                 250                 255     


Cys Lys Lys Pro Ala Gly Arg Asn Thr Gly Pro Trp Leu Lys Lys Val 
            260                 265                 270         


Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser 
        275                 280                 285             


Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro 
    290                 295                 300                 


Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu 
305                 310                 315                 320 


Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Asn Thr Asp 
                325                 330                 335     


Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Ala Ser Gly 
            340                 345                 350         


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
        355                 360                 365             


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
    370                 375                 380                 


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
385                 390                 395                 400 


Thr Phe Ser Asp Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Val Ala Ser Ile Ser Phe Asp Gly Thr Tyr Thr Tyr 
            420                 425                 430         


Tyr Thr Asp Arg Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        435                 440                 445             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    450                 455                 460                 


Ala Val Tyr Tyr Cys Ala Arg Asp Arg Pro Ala Trp Phe Pro Tyr Trp 
465                 470                 475                 480 


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asp Ile Val Met Thr Gln 
            500                 505                 510         


Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser 
        515                 520                 525             


Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu 
    530                 535                 540                 


Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
545                 550                 555                 560 


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
                565                 570                 575     


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
            580                 585                 590         


Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Leu Thr 
        595                 600                 605             


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Pro Ala Gly Ser Gly Ala 
    610                 615                 620                 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
625                 630                 635                 640 


Gly Pro Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu 
                645                 650                 655     


Arg Gly Val Gln Cys Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val 
            660                 665                 670         


Ile Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg 
        675                 680                 685             


Pro Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro 
    690                 695                 700                 


Arg Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly 
705                 710                 715                 720 


Met Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser 
                725                 730                 735     


Cys Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn 
            740                 745                 750         


Ile Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro 
        755                 760                 765             


Gly His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr 
    770                 775                 780                 


Phe Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys 
785                 790                 795                 800 


Lys Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn 
                805                 810                 815     


Glu Asp 
        


<210>  21
<211>  940
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  21

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Ser Gly Gly Gly Ser Gly Ala Pro Thr Thr Thr Pro 
            180                 185                 190         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        195                 200                 205             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    210                 215                 220                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
225                 230                 235                 240 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                245                 250                 255     


Cys Lys Lys Pro Ala Gly Arg Asn Thr Gly Pro Trp Leu Lys Lys Val 
            260                 265                 270         


Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser 
        275                 280                 285             


Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro 
    290                 295                 300                 


Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu 
305                 310                 315                 320 


Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Asn Thr Asp 
                325                 330                 335     


Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Ala Ser Gly 
            340                 345                 350         


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
        355                 360                 365             


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
    370                 375                 380                 


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
385                 390                 395                 400 


Thr Phe Ser Asp Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Val Ala Ser Ile Ser Phe Asp Gly Thr Tyr Thr Tyr 
            420                 425                 430         


Tyr Thr Asp Arg Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        435                 440                 445             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    450                 455                 460                 


Ala Val Tyr Tyr Cys Ala Arg Asp Arg Pro Ala Trp Phe Pro Tyr Trp 
465                 470                 475                 480 


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asp Ile Val Met Thr Gln 
            500                 505                 510         


Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser 
        515                 520                 525             


Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu 
    530                 535                 540                 


Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
545                 550                 555                 560 


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
                565                 570                 575     


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
            580                 585                 590         


Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Leu Thr 
        595                 600                 605             


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Pro Ala Gly Ser Gly Ala 
    610                 615                 620                 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
625                 630                 635                 640 


Gly Pro Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu 
                645                 650                 655     


Arg Gly Val Gln Cys Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val 
            660                 665                 670         


Ile Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg 
        675                 680                 685             


Pro Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro 
    690                 695                 700                 


Arg Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly 
705                 710                 715                 720 


Met Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser 
                725                 730                 735     


Cys Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn 
            740                 745                 750         


Ile Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro 
        755                 760                 765             


Gly His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr 
    770                 775                 780                 


Phe Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys 
785                 790                 795                 800 


Lys Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn 
                805                 810                 815     


Glu Asp Gly Gly Gly Thr Lys Thr Glu Ser Ser Ser Arg Ser Asp Gly 
            820                 825                 830         


Gly Ala Gln Asp Cys Cys Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala 
        835                 840                 845             


Lys Val Val Arg Ser Tyr Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser 
    850                 855                 860                 


Ile Pro Ala Ile Leu Phe Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu 
865                 870                 875                 880 


Cys Ala Asp Pro Lys Glu Leu Trp Val Gln Gln Leu Met Gln His Leu 
                885                 890                 895     


Asp Lys Thr Pro Ser Pro Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp 
            900                 905                 910         


Arg Gly Ala Ser Lys Thr Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys 
        915                 920                 925             


Lys Arg Thr Glu Arg Ser Gln Thr Pro Lys Gly Pro 
    930                 935                 940 


