﻿                               SEQUENCE LISTING

<110> DISTRIBUTED BIO, INC.
 
<120> OPTIMIZED VACCINE COMPOSITIONS AND METHODS FOR MAKING THE SAME

<130> 44561-713.601

<140> PCT/US2020/019367
<141> 2020-02-21

<150> 62/817,902
<151> 2019-03-13

<150> 62/808,760
<151> 2019-02-21

<160> 271   

<170> PatentIn version 3.5

<210> 1
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Glu Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Leu Leu Leu Thr Ala Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Lys Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Thr Lys Gly Val Thr Ala Ala Cys Ser Tyr Ala Gly Ala Ser Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Ser Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Val His His Pro Pro Thr Gly Thr Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Ser Val Gly Ser Ser Lys Tyr Asn 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Asn Arg Gly Ser Gly Ser Gly Ile Ile Thr Ser Asp Ala Pro 
            260                 265                 270         


Val His Asp Cys Asn Thr Lys Cys Gln Thr Pro His Gly Ala Ile Asn 
        275                 280                 285             


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Arg Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ser Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Arg Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Ser Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 2
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Phe Glu Lys Asn Val Ala Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ile Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Ser Leu Leu Pro Ala Arg Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Ser Glu Asn Gly Ala Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Leu 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
        115                 120                 125             


Phe Asn Gly Val Thr Ala Ser Cys Ser His Arg Gly Lys Ser Ser Phe 
    130                 135                 140                 


Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Asp Ser Tyr Pro Lys 
145                 150                 155                 160 


Leu Thr Asn Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val Leu 
                165                 170                 175     


Trp Gly Val His His Pro Ser Ser Ser Asp Glu Gln Gln Ser Leu Tyr 
            180                 185                 190         


Ser Asn Gly Asn Ala Tyr Val Ser Val Ala Ser Ser Asn Tyr Asn Arg 
        195                 200                 205             


Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Lys Asp Gln His 
    210                 215                 220                 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
225                 230                 235                 240 


Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
                245                 250                 255     


Leu Ser Arg Gly Phe Glu Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
            260                 265                 270         


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ser Ile Asn Ser 
        275                 280                 285             


Asn Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Ile Ile Glu 
    370                 375                 380                 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn Leu 
385                 390                 395                 400 


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gly 
            420                 425                 430         


Arg Thr Leu Asp Phe His Asp Leu Asn Val Lys Asn Leu Tyr Glu Lys 
        435                 440                 445             


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
                485                 490                 495     


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505         


<210> 3
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
        115                 120                 125             


Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe 
    130                 135                 140                 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys 
145                 150                 155                 160 


Leu Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu 
                165                 170                 175     


Trp Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Leu Tyr 
            180                 185                 190         


Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg 
        195                 200                 205             


Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala 
    210                 215                 220                 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile 
225                 230                 235                 240 


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala 
                245                 250                 255     


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
            260                 265                 270         


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile Glu 
    370                 375                 380                 


Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
385                 390                 395                 400 


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
            420                 425                 430         


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
        435                 440                 445             


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
                485                 490                 495     


Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser 
            500                 505         


<210> 4
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Gly Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Leu Leu Leu Thr Val Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Thr Asn Gly Val Thr Ala Ala Cys Pro Tyr Ala Gly Ala Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Val Lys Lys Gly Asp Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Val His His Pro Pro Thr Ser Thr Glu Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Ser Val Gly Ser Ser Lys Tyr Asn 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Ala Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Leu Asn Lys Gly Ser Gly Ser Gly Val Ile Thr Ser Asp Ala Pro 
            260                 265                 270         


Val His Asp Cys Asp Thr Lys Cys Gln Thr Pro His Gly Ala Ile Asn 
        275                 280                 285             


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His Gln Gln Asn Gly Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 
385                 390                 395                 400 


Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Ala Cys Met Glu Ser Val 
465                 470                 475                 480 


Arg Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 5
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Ala Asp Thr Ile Cys Ile Gly Tyr Gln Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Leu Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Ser Leu Leu Pro Ala Arg Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Ser Glu Thr Gly Ala Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Leu 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
        115                 120                 125             


Thr Thr Gly Val Thr Lys Ser Cys Ser His Arg Gly Glu Ser Ser Phe 
    130                 135                 140                 


Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Asn Ser Tyr Pro Glu 
145                 150                 155                 160 


Leu Asn Asn Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val Leu 
                165                 170                 175     


Trp Gly Val His His Pro Ser Asn Ser Asn Asn Gln Gln Thr Leu Tyr 
            180                 185                 190         


His Asn Ala Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn Arg 
        195                 200                 205             


Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Asp Gln Thr 
    210                 215                 220                 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
225                 230                 235                 240 


Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
                245                 250                 255     


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
            260                 265                 270         


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asn Arg Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
    370                 375                 380                 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn Leu 
385                 390                 395                 400 


Glu Lys Arg Met Glu Asn Leu Asn Lys Glu Val Asp Asp Gly Phe Leu 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
            420                 425                 430         


Met Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
        435                 440                 445             


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Asp Ser Lys Leu Asn 
                485                 490                 495     


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Pro 
            500                 505         


<210> 6
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Arg Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Leu Ser Glu Arg Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Thr Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Lys His Asn 
        115                 120                 125             


Thr Thr Arg Gly Val Thr Ala Ala Cys Ser His Ala Gly Lys Ser Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asp Gly Ser Tyr Pro 
145                 150                 155                 160 


Asn Leu Asn Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Val His His Pro Ser Asn Ile Lys Asp Gln Gln Thr Leu 
            180                 185                 190         


Tyr Gln Lys Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Met Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
            260                 265                 270         


Met His Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
        275                 280                 285             


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 
385                 390                 395                 400 


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Ile Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 7
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Ser Leu Leu Pro Ala Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Ser Lys Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Lys His Ser 
        115                 120                 125             


Thr Thr Lys Gly Val Thr Ala Ala Cys Ser His Ala Gly Lys Ser Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Glu Asp Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Val His His Pro Ser Ser Ser Lys Glu Gln Gln Thr Leu 
            180                 185                 190         


Tyr Gln Asn Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
        195                 200                 205             


Arg Arg Phe Ile Pro Glu Ile Ala Glu Arg Pro Glu Val Lys Asp Gln 
    210                 215                 220                 


Ala Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Ile Phe Glu Ala Asn Gly Asn Leu Val Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
            260                 265                 270         


Met His Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
        275                 280                 285             


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 
385                 390                 395                 400 


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ile Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Arg Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Lys Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 8
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Lys 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Asn Ile Ala Gly Trp Val Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Leu Ser Asn Arg Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ala Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
        115                 120                 125             


Thr Arg Gly Val Thr Ala Ala Cys Pro His Ala Arg Lys Ser Ser Phe 
    130                 135                 140                 


Tyr Lys Asn Leu Val Trp Leu Thr Glu Ala Asn Gly Ser Tyr Pro Asn 
145                 150                 155                 160 


Leu Ser Arg Ser Tyr Val Asn Asn Gln Glu Lys Glu Val Leu Val Leu 
                165                 170                 175     


Trp Gly Val His His Pro Ser Asn Ile Glu Glu Gln Arg Ala Leu Tyr 
            180                 185                 190         


Arg Lys Asp Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn Arg 
        195                 200                 205             


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Ser 
    210                 215                 220                 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
225                 230                 235                 240 


Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
                245                 250                 255     


Leu Ser Arg Gly Pro Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Leu 
            260                 265                 270         


Asp Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Met Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
    370                 375                 380                 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
385                 390                 395                 400 


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Met 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
            420                 425                 430         


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
        435                 440                 445             


Val Lys Asn Gln Leu Arg Asn Asn Ala Lys Glu Leu Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Lys 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
                485                 490                 495     


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505         


<210> 9
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Lys Leu Gly Gly Ile 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Leu Leu Leu Thr Val Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Asn Arg Gly Val Thr Ala Ala Cys Pro Tyr Ala Gly Ala Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Glu Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Pro Thr Ser Thr Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Lys Tyr Asn 
        195                 200                 205             


Arg Lys Phe Lys Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Ile Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Asn Arg Gly Ser Gly Ser Gly Ile Ile Ile Ser Asp Ala Pro 
            260                 265                 270         


Val His Asp Cys Asn Thr Lys Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Arg Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Thr Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 10
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Phe Ser Lys Lys Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ala Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Lys His Asn 
        115                 120                 125             


Val Thr Arg Gly Val Thr Ala Ser Cys Ser His Lys Gly Lys Ser Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Ser Tyr Pro 
145                 150                 155                 160 


Asn Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Val His His Pro Ser Asn Ile Glu Asp Gln Lys Thr Ile 
            180                 185                 190         


Tyr Arg Lys Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Ala Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp His Ala Phe 
                245                 250                 255     


Ala Leu Asn Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
            260                 265                 270         


Met Asp Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
        275                 280                 285             


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
385                 390                 395                 400 


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 11
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Ser Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Phe Ser Lys Lys Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ala Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
        115                 120                 125             


Val Thr Lys Gly Val Thr Ala Ser Cys Ser His Lys Gly Lys Ser Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Ser Tyr Pro 
145                 150                 155                 160 


Thr Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Val His His Pro Ser Asn Ile Gly Asp Gln Arg Ala Ile 
            180                 185                 190         


Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Asn 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
            260                 265                 270         


Met Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
        275                 280                 285             


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
385                 390                 395                 400 


Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 12
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Lys Cys Glu Ser Leu Phe Ser Lys Glu Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ala Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
        115                 120                 125             


Val Thr Lys Gly Val Thr Thr Ser Cys Ser His Asn Gly Lys Ser Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Leu Tyr Pro 
145                 150                 155                 160 


Asn Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Val His His Pro Ser Asn Ile Arg Asp Gln Arg Ala Ile 
            180                 185                 190         


Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
            260                 265                 270         


Met Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
        275                 280                 285             


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
385                 390                 395                 400 


Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Gly Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Gly Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 13
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Ala Asp Thr Ile Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asn Asn His Asn Gly Lys Leu Cys Ser Leu Asn Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asp Cys Asn Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Ser Leu Leu Thr Ala Asn Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ile Glu Thr Ser Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Glu Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Leu Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Ala Thr Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Thr Lys Gly Val Thr Ala Ala Cys Ser His Ser Gly Ala Arg Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Ile Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Thr Asn Asn Arg Arg Lys Glu Val Leu Val 
                165                 170                 175     


Ile Trp Gly Val His His Pro Pro Thr Asn Asn Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Ser Val Gly Ser Ser Lys Tyr Tyr 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Asp Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Met Leu Asp Gln Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Asn Lys Gly Leu Ser Ser Gly Ile Ile Met Ser Asp Ala Pro 
            260                 265                 270         


Val His Asn Cys Thr Thr Arg Cys Gln Thr Pro Tyr Gly Ala Leu Asn 
        275                 280                 285             


Ser Asn Leu Pro Phe Gln Asn Val His Pro Ile Thr Ile Gly Lys Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Gln Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Ser Asn Lys Val Asn Ser Ile Ile 
    370                 375                 380                 


Glu Lys Met Asn Ile Gln Phe Thr Ser Val Gly Lys Glu Phe Asn Asp 
385                 390                 395                 400 


Leu Glu Lys Arg Val Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Phe Asn Val Arg Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Val Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Arg Asn Gly Thr Tyr Asn Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 14
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
        115                 120                 125             


Val Thr Gly Val Thr Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
    130                 135                 140                 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Leu Tyr Pro Asn 
145                 150                 155                 160 


Leu Ser Asn Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
                165                 170                 175     


Trp Gly Val His His Pro Ser Asn Ile Arg Asp Gln Arg Ala Ile Tyr 
            180                 185                 190         


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
        195                 200                 205             


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Gly Gln Glu 
    210                 215                 220                 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
225                 230                 235                 240 


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
                245                 250                 255     


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
            260                 265                 270         


Asn Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Met Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
    370                 375                 380                 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
385                 390                 395                 400 


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
            420                 425                 430         


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
        435                 440                 445             


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
                485                 490                 495     


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505         


<210> 15
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asn Asn His Asn Gly Lys Leu Cys Asn Leu Asn Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Lys Cys Asn Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Gly Leu Leu Leu Asn Ala Asn Ala Trp Ser Tyr Ile 
65                  70                  75                  80  


Ile Glu Thr Ser Asp Ser Lys Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Gly Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Lys Phe Glu Ile Phe Pro Lys Ala Ser Ser Trp Pro Asp His Glu 
        115                 120                 125             


Thr Thr Lys Gly Thr Thr Ala Ala Cys Pro Tyr Ser Gly Val Glu Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Ile Ile Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Ile Ser Lys Ser Tyr Thr Asn Asn Arg Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Val His His Pro Pro Thr Thr Ser Asp Gln Gln Thr Leu 
            180                 185                 190         


Tyr Gln Asn Ile Asp Ala Tyr Val Ser Val Gly Ser Ser Lys Tyr Asn 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Gly Leu 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Asp Gln Gly Asp Thr 
225                 230                 235                 240 


Ile Met Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Asn Lys Gly Ser Asp Ser Gly Ile Ile Thr Ser Asp Thr Pro 
            260                 265                 270         


Val His Asp Cys Asp Thr Lys Cys Gln Thr Pro Tyr Gly Ala Leu Asn 
        275                 280                 285             


Ser Ser Leu Pro Phe Gln Asn Val His Pro Ile Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Val Pro Ser Ile Gln Ser Lys Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ser Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 
385                 390                 395                 400 


Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Arg Asp Leu Tyr Glu 
        435                 440                 445             


Arg Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Glu Cys Met Glu Asn Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
                485                 490                 495     


Asn Arg Glu Lys Ile Asp Gly Val Lys Ile Glu Ser 
            500                 505             


<210> 16
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Phe Glu Lys Asn Val Ala Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
        115                 120                 125             


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
    130                 135                 140                 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
145                 150                 155                 160 


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
                165                 170                 175     


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Gln Gly Leu Tyr 
            180                 185                 190         


Ser Asn Gly Asn Ala Tyr Val Ser Val Ala Ser Ser Asn Tyr Asn Arg 
        195                 200                 205             


Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Lys Asp Gln His 
    210                 215                 220                 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
225                 230                 235                 240 


Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
                245                 250                 255     


Leu Ser Arg Gly Phe Glu Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
            260                 265                 270         


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ser Ile Asn Ser 
        275                 280                 285             


Asn Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
    370                 375                 380                 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Arg Leu 
385                 390                 395                 400 


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
            420                 425                 430         


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
        435                 440                 445             


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
                485                 490                 495     


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505         


<210> 17
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asn Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Phe Glu Ala Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asn Tyr Glu Glu Leu Arg Glu His Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Ala Asn Ser Trp Pro Asn His Asp 
        115                 120                 125             


Thr Asp Ser Gly Val Thr Ala Ser Cys Pro Tyr Ala Gly Ala Lys Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Gly Ser Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Lys Lys Glu Val Leu Val 
                165                 170                 175     


Ile Trp Gly Ile His His Pro Pro Asn Ser Thr Asp Gln Gln Thr Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Lys Tyr Ser 
        195                 200                 205             


Lys Arg Phe Lys Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Ile Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Thr Arg Gly Ser Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
            260                 265                 270         


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Lys Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Gln 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Ser Leu Asn Asn Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Thr Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 18
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Ile Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asn Lys His Asn Gly Lys Leu Cys Lys Leu Gly Gly Met 
        35                  40                  45              


Thr Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Leu Leu Ser Thr Val Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Tyr Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Thr Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Ala Ser Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Asn Arg Gly Val Thr Ser Ala Cys Pro Tyr Ala Gly Glu Asn Asp 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Ile 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Pro Thr Ser Ala Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser Thr Tyr Asn 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Val Ala Ala Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Ala Gly Arg Met Asp Tyr Tyr Trp Thr Leu Ile Gly Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Asn Arg Gly Ser Gly Ser Gly Ile Ile Ile Ser Asp Ile Pro 
            260                 265                 270         


Phe His Asn Cys Thr Thr Lys Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Arg Arg Ile Glu Asn Leu Asn Arg Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Ile Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Leu His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Ala Cys Met Glu Ser Val 
465                 470                 475                 480 


Arg Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Arg Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 19
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Phe Thr Ala Arg Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Asn Thr Ser Ser Trp Pro Asn His Asp 
        115                 120                 125             


Thr Asn Arg Gly Val Thr Ala Ala Cys Pro His Ala Gly Thr Lys Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Gly Asp Ser Tyr Pro 
145                 150                 155                 160 


Lys Ile Ser Lys Ser Tyr Ile Asn Asn Lys Glu Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Lys Tyr Ser 
        195                 200                 205             


Lys Lys Phe Lys Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Glu Gly Arg Met Asp Tyr Tyr Trp Thr Ile Val Glu Pro Gly Asp Lys 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Glu Leu Lys Arg Asn Ser Gly Ser Gly Ile Ile Ile Ser Asp Thr Ser 
            260                 265                 270         


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Ser His 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Met Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 20
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Ala Asp Thr Ile Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Ser Asn His Asn Gly Lys Leu Cys Ser Leu Asn Gly Lys 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Asn Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Leu Leu Leu Thr Ala Asn Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ile Glu Thr Ser Asn Ser Lys Asn Gly Ala Cys Tyr Pro Gly Glu Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Leu Leu Ser Thr Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Ala Thr Ser Trp Pro His His Glu 
        115                 120                 125             


Thr Thr Lys Gly Thr Thr Val Ala Cys Pro His Ser Gly Val Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Ile Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Thr Asn Ser Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Ile Trp Gly Val His His Pro Pro Thr Asp Ser Asp Gln Gln Thr Leu 
            180                 185                 190         


Tyr Gln Asn Asn His Thr Tyr Val Ser Val Gly Thr Ser Lys Tyr Tyr 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Val Ala Arg Pro Lys Ile Arg Glu Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Asp Gln Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Leu Glu Ala Thr Gly Asn Leu Ile Val Pro Trp His Ala Phe 
                245                 250                 255     


Ala Leu Asn Lys Gly Ser Asn Ser Gly Ile Met Ile Ser Asp Ala Asp 
            260                 265                 270         


Phe His Asn Cys Thr Thr Lys Cys Gln Thr Pro His Gly Ala Leu Lys 
        275                 280                 285             


Ser Asn Leu Pro Phe Gln Asn Val His Pro Ile Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Gln Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Ile Ala Ile Asp Gly Ile Ser Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Ile Gln Phe Ala Ser Val Gly Lys Glu Phe Asn Asp 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Val Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Ile Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Phe Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asn Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 21
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Lys His Asn Gly Arg Leu Cys Lys Leu Gly Gly Ile 
        35                  40                  45              


Ala Pro Leu Asn Leu Gly Arg Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Phe Thr Val Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Tyr Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Met Ala Ser Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Thr Lys Gly Val Thr Ala Ala Cys Ser His Ala Gly Glu Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Glu Asn Thr Tyr Pro 
145                 150                 155                 160 


Lys Ile Ser Lys Ser Tyr Ile Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Pro Thr Asn Asn Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Thr Ser Lys Tyr Asn 
        195                 200                 205             


Lys Lys Phe Lys Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Ala Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Asn Lys Gly Ser Gly Ser Gly Ile Ile Val Ser Asp Ile Pro 
            260                 265                 270         


Ala His Asp Cys Asn Thr Asn Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Arg Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Gly Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Ile Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Ala Arg Arg Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Ala Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Arg Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Asp Ser 
            500                 505             


<210> 22
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asn Lys His Asp Gly Lys Leu Cys Lys Leu Arg Gly Ile 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Phe Thr Thr Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asn Tyr Glu Glu Leu Arg Glu His Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Ala Asn Ser Trp Pro Tyr His Asp 
        115                 120                 125             


Thr Asn Lys Gly Val Thr Ala Ala Cys Pro Tyr Ala Gly Ala Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Ile Asn Asn Lys Lys Lys Glu Val Leu Val 
                165                 170                 175     


Ile Trp Gly Ile His His Pro Pro Thr Ser Thr Asp Gln Gln Thr Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Lys Tyr Ser 
        195                 200                 205             


Lys Arg Phe Lys Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Ala Gly Arg Met Asp Tyr Tyr Trp Thr Leu Ile Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Thr Met Lys Arg Gly Ser Gly Ser Gly Ile Ile Val Ser Asp Ala Pro 
            260                 265                 270         


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Ser Gln 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Ser Leu Asn Asn Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Thr Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
                485                 490                 495     


Asn Arg Gln Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 23
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Asn Leu Arg Gly Glu 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Leu Leu Phe Ala Val Asn Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Thr Ser Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Ala Ser Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Asn Arg Gly Val Thr Ala Ala Cys Pro Tyr Ala Gly Thr Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Lys Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Pro Thr Asn Ala Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Lys Tyr Asn 
        195                 200                 205             


Lys Lys Phe Lys Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Ala Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Asn Arg Asp Pro Gly Ser Gly Ile Ile Thr Ser Asp Ala Pro 
            260                 265                 270         


Ile His Asp Cys Asn Ala Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Arg Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Gly Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Arg Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Thr Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Thr Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Thr Cys Met Glu Ser Ile 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Lys Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Gln Leu Glu Ser 
            500                 505             


<210> 24
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Ala Asp Thr Leu Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Asn His Asn Gly Lys Leu Cys Lys Leu Arg Gly Ile 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Leu Leu Phe Thr Ala Lys Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Pro Asp Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ser Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Asn Ala Ser Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Asn Arg Gly Ile Thr Ala Ala Cys Pro Tyr Ala Gly Ala Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Ile Asn Lys Ser Tyr Ile Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Ser Thr Ser Asn Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Lys Tyr Asn 
        195                 200                 205             


Arg Arg Phe Lys Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Thr Arg Gly Ser Gly Ser Gly Ile Met Ile Ser Asp Thr Pro 
            260                 265                 270         


Val Tyr Asp Cys Asn Thr Ile Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Lys Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Tyr Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Phe Ala Ala Asp Arg Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Val Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Arg Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 25
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Ala Asp Thr Ile Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Ile Leu Glu Thr Thr His Asn Gly Lys Leu Cys Ser Leu Ser Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Asn Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Leu Leu Leu Thr Val Asn Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ile Glu Thr Ser Asn Ser Val Asn Gly Thr Cys Tyr Pro Gly Glu Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ala Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Thr Thr Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Thr Arg Gly Thr Thr Ala Ala Cys Ser His Ser Gly Thr Arg Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Ile Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Ile Ser Lys Ser Tyr Thr Asn Lys Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Ile Trp Gly Val His His Pro Pro Thr Asn Asn Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Tyr Thr Tyr Val Ser Val Glu Ser Ser Lys Tyr Tyr 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Ser Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Asp Gln Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Asn Lys Gly Ser Asp Ser Gly Ile Ile Ile Ser Asp Ala Gln 
            260                 265                 270         


Val His Asn Cys Thr Thr Lys Cys Gln Thr Pro His Gly Ala Leu Asn 
        275                 280                 285             


Ser Thr Leu Pro Phe Gln Asn Val His Pro Ile Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr His Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Lys Ser 
        355                 360                 365             


Thr Gln Ile Ala Ile Asp Gly Ile Ser Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Ile Gln Phe Thr Ser Val Gly Lys Glu Phe Asn Asn 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Phe Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Phe Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Arg Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Val Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asn Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 26
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Ile Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Phe Asn Val Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Thr Asn Tyr Glu Glu Leu Lys Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Gly Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Asn Arg Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Asn Ser 
    130                 135                 140                 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Arg Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Asn Lys Ser Tyr Val Asn Asn Lys Lys Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Pro Thr Ser Thr Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Lys Tyr Ser 
        195                 200                 205             


Lys Lys Phe Lys Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Glu Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Asn Arg Gly Ser Gly Ser Gly Ile Ile Thr Ser Asp Thr Pro 
            260                 265                 270         


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Val His Pro Ile Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Gly Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Ala Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Arg Asn Leu Tyr Asp 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Thr Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Arg Leu Asp Ser 
            500                 505             


<210> 27
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Arg Glu Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
        115                 120                 125             


Thr Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe 
    130                 135                 140                 


Tyr Lys Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
145                 150                 155                 160 


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
                165                 170                 175     


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
            180                 185                 190         


His Lys Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
        195                 200                 205             


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
    210                 215                 220                 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
225                 230                 235                 240 


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
                245                 250                 255     


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro Met 
            260                 265                 270         


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
    370                 375                 380                 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
385                 390                 395                 400 


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Ile 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
            420                 425                 430         


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
        435                 440                 445             


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
                485                 490                 495     


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505         


<210> 28
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Ile Asn 
            20                  25                  30          


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Arg Leu Arg Gly Val 
        35                  40                  45              


Thr Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Asn Ala Ser Ser Trp Pro Asp His Glu 
        115                 120                 125             


Thr Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Val Lys Lys Lys Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Ile Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Ser Asn Ile Gln Asp Gln Glu Thr Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser Lys Tyr Ser 
        195                 200                 205             


Lys Lys Phe Lys Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Thr Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Ile Pro Lys Tyr Ala Phe 
                245                 250                 255     


Ala Met Lys Arg Gly Ser Gly Ser Gly Ile Ile Ile Ser Asp Ala Thr 
            260                 265                 270         


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Arg Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Ser Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Ala Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
                485                 490                 495     


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 29
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Thr His Asn Gly Lys Leu Cys Lys Leu Gly Gly Met 
        35                  40                  45              


Ala Pro Leu His Leu Gly Arg Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Leu Ile Ser Thr Val Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Thr Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Lys Phe Glu Met Phe Pro Lys Ile Ser Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Asn Arg Gly Val Thr Ala Ala Cys Pro Tyr Ala Gly Ala Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Pro Thr Ser Ala Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Val Asp Thr Tyr Val Phe Val Gly Ser Ser Thr Tyr Asn 
        195                 200                 205             


Arg Lys Phe Lys Pro Glu Ile Ala Val Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Thr Gly Arg Met Asn Tyr Tyr Trp Thr Leu Ile Lys Pro Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Ala Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Ser Arg Gly Ser Gly Ser Gly Ile Ile Thr Ser Asp Met Pro 
            260                 265                 270         


Val His Asn Cys Thr Thr Lys Cys Gln Thr Pro Lys Gly Ala Leu Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Ile Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Leu His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ala Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Ala Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Arg Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 30
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asn Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
        115                 120                 125             


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe 
    130                 135                 140                 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
145                 150                 155                 160 


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
                165                 170                 175     


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Lys Ala Leu Tyr 
            180                 185                 190         


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
        195                 200                 205             


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
    210                 215                 220                 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
225                 230                 235                 240 


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
                245                 250                 255     


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro Met 
            260                 265                 270         


Asp Lys Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
    370                 375                 380                 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
385                 390                 395                 400 


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Ile 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
            420                 425                 430         


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
        435                 440                 445             


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
                485                 490                 495     


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505         


<210> 31
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Ala Asp Thr Ile Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Ile Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asn Ser His Asn Gly Lys Leu Cys Ser Leu Asn Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Ser Cys Asn Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Leu Leu Leu Thr Val Asn Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Glu Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Thr Thr Ser Trp Pro Asn His Asp 
        115                 120                 125             


Thr Thr Lys Gly Thr Thr Ala Ala Cys Ser His Ser Gly Thr Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Ile Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Asn Ser Ser Tyr Thr Asn Asn Lys Gly Lys Glu Val Leu Ile 
                165                 170                 175     


Ile Trp Gly Val His His Pro Pro Thr Asn Asn Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Thr Tyr Val Ser Val Gly Ser Ser Lys Tyr Tyr 
        195                 200                 205             


Gln Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Asp Gln Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Asn Lys Asn Ser Gly Ser Gly Ile Met Ile Ser Asp Ala Gln 
            260                 265                 270         


Val His Asn Cys Thr Thr Lys Cys Gln Thr Pro His Gly Ala Met Asn 
        275                 280                 285             


Ser Asn Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Gln Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Gly Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Leu Ala Ile Asp Gly Ile Ser Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Ile Gln Phe Thr Ser Val Gly Lys Glu Phe Asn Asn 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Ile Leu Ile Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Phe Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Val Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Arg Asn Gly Thr Tyr Asn Tyr Ser Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 32
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Ala Asp Thr Leu Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Lys Leu Gly Gly Ile 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Ser Leu Leu Thr Val Arg Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Glu Phe 
                85                  90                  95      


Ile Asn Tyr Glu Glu Leu Lys Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Ala Ser Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Asn Lys Gly Val Thr Ala Ala Cys Pro Tyr Ala Gly Ser Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Asn Lys Ser Tyr Ile Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Pro Thr Asn Asn Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Glu Asp Ala Tyr Val Phe Ile Gly Ser Ser Lys Tyr Asn 
        195                 200                 205             


Lys Lys Phe Lys Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Gly Gln 
    210                 215                 220                 


Ala Gly Arg Met Asp Tyr Tyr Trp Leu Leu Met Glu Pro Gly Glu Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Asn Arg Asp Ala Arg Ser Gly Ile Ile Ile Ser Asp Val Ser 
            260                 265                 270         


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Leu Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Ile Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Ala Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Lys Arg Leu Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Arg Cys Asp Asp Ala Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Val Tyr Ser Glu Glu Ser Arg Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Asp Ser 
            500                 505             


<210> 33
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
        115                 120                 125             


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
    130                 135                 140                 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
        195                 200                 205             


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Arg 
    210                 215                 220                 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
            260                 265                 270         


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 34
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Asn His Asn Gly Lys Leu Cys Ser Leu Lys Gly Ile 
        35                  40                  45              


Val Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Lys Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Pro Glu Asn Gly Ala Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
        115                 120                 125             


Val Asn Gly Val Ser Ala Ala Cys Ser His Asn Gly Glu Arg Ser Phe 
    130                 135                 140                 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
145                 150                 155                 160 


Leu Thr Asn Ser Tyr Val Asn Ser Lys Glu Lys Glu Val Leu Ile Leu 
                165                 170                 175     


Trp Gly Val His His Pro Ser Asn Ile Arg Asp Gln Arg Thr Leu Tyr 
            180                 185                 190         


Gln Thr Glu Asn Ala Tyr Val Ser Val Met Ser Ser His Tyr Ser Arg 
        195                 200                 205             


Arg Phe Thr Pro Glu Ile Thr Lys Arg Pro Lys Val Arg Asp Gln Glu 
    210                 215                 220                 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
225                 230                 235                 240 


Ile Phe Glu Ala Ser Gly Asn Leu Ile Ala Pro Trp Tyr Gly Phe Glu 
                245                 250                 255     


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Ser Ala Pro Thr 
            260                 265                 270         


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Glu Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
    370                 375                 380                 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
385                 390                 395                 400 


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
            420                 425                 430         


Arg Thr Leu Asp Phe His Asp Ser Asn Val Arg Ser Leu Tyr Glu Lys 
        435                 440                 445             


Val Arg Val Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Arg 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
                485                 490                 495     


Arg Glu Lys Ile Asp Gly Val Lys Leu Asp Ser 
            500                 505         


<210> 35
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asn Arg His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
        115                 120                 125             


Thr Asn Arg Gly Val Thr Ala Ala Cys Pro His Asp Gly Thr Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Ile Asn Lys Ser Tyr Ile Asn Asn Lys Glu Lys Glu Ile Leu Val 
                165                 170                 175     


Leu Trp Ala Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
        195                 200                 205             


Arg Lys Phe Glu Pro Glu Val Ala Thr Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Leu Lys Arg Asn Ser Gly Ser Gly Ile Ile Ile Ser Asp Thr Ser 
            260                 265                 270         


Val His Asp Cys Asp Thr Asn Cys Gln Thr Pro Asn Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Ser His 
385                 390                 395                 400 


Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Met Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 36
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Ala Asp Thr Leu Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
        35                  40                  45              


Pro Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Pro Leu Leu Thr Thr Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Ile Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
        115                 120                 125             


Ser Asn Ser Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Ile Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Pro Thr Ser Ala Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Val Asp Thr Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
        195                 200                 205             


Lys Lys Phe Lys Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Met Arg Arg Asn Ser Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
            260                 265                 270         


Val His Asp Cys Asn Ala Thr Cys Gln Thr Pro Asn Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Ile Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Arg Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Asp Gly Val Arg Leu Glu Ser 
            500                 505             


<210> 37
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Ile Ser Lys Lys Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Pro Asn Pro Glu Asn Gly Ala Cys Tyr Pro Gly Glu Phe 
                85                  90                  95      


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
        115                 120                 125             


Ala Thr Gly Glu Ser Ala Ser Cys Ser His Asn Gly Lys Lys Ser Phe 
    130                 135                 140                 


Tyr Arg Asn Leu Ile Trp Leu Thr Val Lys Asn Gly Leu Tyr Pro Asn 
145                 150                 155                 160 


Leu Ser Lys Ser Tyr Glu Asn Asp Lys Glu Lys Glu Val Leu Ile Leu 
                165                 170                 175     


Trp Gly Val His His Pro Pro Asn Ile Glu Asn Gln Arg Thr Leu Tyr 
            180                 185                 190         


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Gly 
        195                 200                 205             


Arg Phe Thr Pro Glu Ile Thr Lys Arg Pro Lys Val Arg Asp Gln Glu 
    210                 215                 220                 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
225                 230                 235                 240 


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
                245                 250                 255     


Leu Ser Arg Gly Leu Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
            260                 265                 270         


Asp Glu Cys Asp Ser Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Glu Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
    370                 375                 380                 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
385                 390                 395                 400 


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
            420                 425                 430         


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Ser Leu Tyr Glu Lys 
        435                 440                 445             


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Tyr Glu Glu Ser Lys Leu Asn 
                485                 490                 495     


Arg Glu Lys Ile Asp Gly Val Lys Leu Asp Ser 
            500                 505         


<210> 38
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Ile Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asp Cys Ser Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Asn Cys Glu Ser Leu Phe Ser Lys Lys Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ala Glu Ile Pro Asn Pro Glu Asn Gly Ile Cys Tyr Pro Gly Tyr Phe 
                85                  90                  95      


Ser Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Ile Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Lys His Ser 
        115                 120                 125             


Val Asn Lys Gly Val Thr Ala Ser Cys Ser His Lys Gly Lys Ser Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Ser Tyr Pro 
145                 150                 155                 160 


Asn Leu Ser Lys Ser Tyr Val Asn Ser Arg Glu Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Val His His Pro Ser Asn Ile Glu Asp Gln Arg Ala Ile 
            180                 185                 190         


Tyr Arg Lys Glu Asn Ala Tyr Ile Ser Val Val Ser Ser Leu Tyr Asn 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Arg Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Ile Leu Glu Pro Arg Asp Thr 
225                 230                 235                 240 


Ile Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ser Leu Ser Arg Gly Phe Lys Ser Gly Ile Ile Val Ser Asn Ser Ser 
            260                 265                 270         


Ile Asp Asn Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
        275                 280                 285             


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Gln Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Asp Lys Met Asn Thr Gln Phe Ala Ser Val Gly Lys Glu Phe Asn Lys 
385                 390                 395                 400 


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Ser Leu Tyr Asn 
        435                 440                 445             


Lys Val Lys Gly Gln Leu Lys Ser Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Lys Glu Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Lys Ile Asp Gly Val Glu Leu Lys Ser 
            500                 505             


<210> 39
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Asn Gly Ile 
        35                  40                  45              


Ser Pro Leu Gln Leu Gly Thr Cys Ser Ile Ala Gly Trp Val Leu Gly 
    50                  55                  60                  


Asn Pro Lys Cys Glu Ser Leu Phe Ser Arg Arg Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ala Glu Val Pro Asn Pro Glu Asn Gly Ile Cys Tyr Pro Gly His Phe 
                85                  90                  95      


Ser Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Gly His Asn 
        115                 120                 125             


Leu Thr Lys Gly Val Thr Ala Ser Cys Ser His Asn Gly Lys Ser Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Gly Glu Lys Gly Leu Tyr Pro 
145                 150                 155                 160 


Lys Val Asn Lys Ser Tyr Val Asn Asn Lys Lys Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Val His His Pro Ser Asn Ile Glu Asp Gln Arg Ala Ile 
            180                 185                 190         


Tyr His Glu Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Ala Arg Arg Pro Lys Ile Arg Asn Gln 
    210                 215                 220                 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Asp Asp Lys 
225                 230                 235                 240 


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe 
                245                 250                 255     


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Val Ser Asn Thr Ser 
            260                 265                 270         


Ile Asp Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
        275                 280                 285             


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Arg Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Glu Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
385                 390                 395                 400 


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Asp Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Arg Tyr Ser Glu Glu Ser Ser Leu 
                485                 490                 495     


Asn Arg Gly Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 40
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Ser Ser His Asn Gly Lys Leu Cys Arg Met Lys Gly Met 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Lys Cys Ser Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Ser Phe Ser Arg Lys Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ala Glu Ala Pro Asn Pro Glu Asn Gly Ile Cys Tyr Pro Gly Tyr Phe 
                85                  90                  95      


Ser Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Val 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Lys His Asn 
        115                 120                 125             


Val Thr Arg Gly Lys Thr Val Ser Cys Pro His Asn Gly Lys Ser Ser 
    130                 135                 140                 


Phe Tyr Lys Asn Leu Leu Trp Leu Thr Glu Lys Asp Gly Ser Tyr Pro 
145                 150                 155                 160 


Asn Val Ser Lys Pro Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
                165                 170                 175     


Ile Trp Gly Val His Asn Pro Ser Asn Ile Glu Asp Gln Arg Ala Ile 
            180                 185                 190         


Tyr Arg Lys Glu Thr Ala Tyr Val Ser Val Val Ser Ser His Tyr Asn 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Glu Lys Arg Pro Lys Ile Lys Asn Gln 
    210                 215                 220                 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Glu Thr 
225                 230                 235                 240 


Ile Ile Phe Glu Ala Asn Gly Asn Phe Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Ser Arg Gly Phe Arg Ser Gly Ile Ile Val Ser Asn Ala Ser 
            260                 265                 270         


Met Asp Glu Cys Asp Thr Glu Cys Gln Thr Pro Gln Gly Ala Ile Asn 
        275                 280                 285             


Asn Ser Leu Pro Phe Gln Asn Val His Pro Val Ala Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Ile Lys Ser Thr Arg Leu Arg Met Val Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Arg Asn Glu Gln Gly Ser Gly Phe Ala Ala Asp Gln Glu Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Ile Ile 
    370                 375                 380                 


Gly Lys Met Asn Thr Gln Phe Thr Ala Ala Gly Lys Glu Phe Asn Arg 
385                 390                 395                 400 


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Leu 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Ser Leu 
                485                 490                 495     


Asn Arg Arg Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 41
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Ala Asp Thr Ile Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Ile Asn 
            20                  25                  30          


Leu Leu Glu Ser Ser His Asn Gly Lys Leu Cys Ser Leu Asn Gly Ile 
        35                  40                  45              


Ala Pro Leu Gln Leu Gly Asn Cys Asn Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Leu Ser Phe Thr Ala Asn Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ile Glu Thr Ser Asn Ser Glu Asn Gly Ala Cys Tyr Pro Gly Lys Phe 
                85                  90                  95      


Thr Asp Tyr Glu Glu Leu Arg Glu Lys Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Ala Thr Ser Trp Pro Asn His Glu 
        115                 120                 125             


Thr Asn Lys Gly Thr Thr Ala Ala Cys Ser His Ser Gly Val Lys Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Ile Val Lys Lys Gly Asn Ser Tyr Thr 
145                 150                 155                 160 


Lys Val Asn Lys Ser Tyr Thr Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Ile Trp Gly Val His His Pro Pro Thr Asn Asn Val Gln Gln Thr Leu 
            180                 185                 190         


Tyr Gln Asn Ala Ser Thr Tyr Val Ser Val Gly Thr Ser Lys Tyr Tyr 
        195                 200                 205             


Arg Arg Phe Thr Pro Glu Ile Val Ala Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Ala Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Asp Gln Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Asn Lys Gly Ser Val Ser Gly Ile Ile Ile Ser Asp Ala Asn 
            260                 265                 270         


Val His Asn Cys Thr Thr Lys Cys Gln Thr Pro His Gly Ala Leu Lys 
        275                 280                 285             


Ser Arg Leu Pro Phe Gln Asn Val His Pro Ile Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Gln Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
        355                 360                 365             


Thr Gln Ser Ala Ile Asp Gly Ile Ser Asn Lys Val Asn Ser Ile Ile 
    370                 375                 380                 


Glu Lys Met Asn Val Gln Phe Thr Ser Val Gly Lys Glu Phe Asn Asn 
385                 390                 395                 400 


Leu Glu Lys Arg Leu Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Ile Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Phe Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Arg Asp Asn Ala Lys Glu Val Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Ile 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Glu Ile Tyr Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 42
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Ala Asp Thr Ile Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asn Ser His Asn Gly Lys Leu Cys Ser Leu Asn Gly Lys 
        35                  40                  45              


Ala Pro Leu Gln Leu Glu Asn Cys Asn Val Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Asp Phe Leu Leu Thr Ala Tyr Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Ile Glu Thr Ser Asn Ser Lys Asn Gly Thr Cys Tyr Pro Gly Glu Phe 
                85                  90                  95      


Asn Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Thr Val Ser Ser Leu 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Ala Thr Ser Trp Pro Asn His Asp 
        115                 120                 125             


Thr Thr Lys Gly Thr Thr Val Ala Cys Ser His Ser Gly Ala Asn Ser 
    130                 135                 140                 


Phe Tyr Arg Asn Leu Leu Trp Ile Val Lys Lys Glu Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Ser Lys Ser Tyr Thr Asn Asn Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Ile Trp Gly Val His His Pro Pro Thr Asp Ser Asp Gln Gln Thr Leu 
            180                 185                 190         


Tyr Gln Asn Asn Asn Thr Tyr Val Ser Val Glu Ser Ser Lys Tyr Tyr 
        195                 200                 205             


Gln Arg Phe Thr Pro Glu Ile Val Ala Arg Pro Lys Val Arg Lys Gln 
    210                 215                 220                 


Ala Gly Arg Met Asn Tyr Tyr Trp Ile Leu Leu Asp Gln Gly Asp Thr 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
                245                 250                 255     


Ala Leu Asp Lys Gly Ser Ser Ser Gly Ile Met Met Ser Asp Ala His 
            260                 265                 270         


Val Gln Asn Cys Thr Thr Lys Cys Gln Thr Pro His Gly Ala Leu Lys 
        275                 280                 285             


Ser Asn Leu Pro Phe Gln Asn Val His Pro Ile Thr Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Gln Leu Arg Met Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Lys Ser 
        355                 360                 365             


Thr Gln Ile Ala Ile Asp Gly Ile Ser Asn Lys Val Asn Ser Ile Ile 
    370                 375                 380                 


Glu Lys Met Asn Ile Gln Phe Thr Ser Val Gly Lys Glu Phe Asn Asn 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Ile Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Phe His Asp Phe Asn Val Arg Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Arg Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Ile 
465                 470                 475                 480 


Arg Asn Gly Thr Tyr Asn Tyr Pro Arg Tyr Ser Glu Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 43
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
1               5                   10                  15      


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
            20                  25                  30          


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
        35                  40                  45              


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
    50                  55                  60                  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
            100                 105                 110         


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
        115                 120                 125             


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
    130                 135                 140                 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
145                 150                 155                 160 


Lys Leu Asn Gln Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
                165                 170                 175     


Leu Trp Gly Ile His His Pro Ser Thr Thr Ala Asp Gln Gln Ser Leu 
            180                 185                 190         


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser Arg Tyr Ser 
        195                 200                 205             


Lys Lys Phe Lys Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Asp Gln 
    210                 215                 220                 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
225                 230                 235                 240 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
                245                 250                 255     


Thr Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
            260                 265                 270         


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Glu Gly Ala Ile Asn 
        275                 280                 285             


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
        355                 360                 365             


Thr Gln Asn Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile 
    370                 375                 380                 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
385                 390                 395                 400 


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
                405                 410                 415     


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Arg Asn Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
                485                 490                 495     


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
            500                 505             


<210> 44
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Asp Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Lys Ile Cys Asn Asn Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Ile Asp Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Val Phe Gln Asn Glu Thr Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Phe Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Ile 
            100                 105                 110         


Thr Glu Gly Thr Trp Thr Gly Val Thr Gln Asn Gly Gly Ser Asn Ala 
        115                 120                 125             


Cys Lys Arg Gly Pro Gly Ser Gly Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


Thr Lys Ser Gly Ser Thr Tyr Pro Val Leu Asn Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Asp Asn Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Ser 
                165                 170                 175     


Thr Asn Gln Glu Gln Thr Ser Leu Tyr Val Gln Ala Ser Gly Arg Val 
            180                 185                 190         


Thr Val Ser Thr Arg Arg Ser Gln Gln Thr Ile Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Trp Val Arg Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Val Leu Val Ile Asn Ser Asn Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Met Arg Thr Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Asp Thr Cys Ile Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Lys Ile Thr Tyr Gly Ala Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Val Ile Glu Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Glu Ser Ile Arg Asn Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 45
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Arg Ile Cys Asp Ser Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Gly Phe Gln Asn Glu Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Phe Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Ile 
            100                 105                 110         


Asn Glu Gly Asn Trp Thr Gly Val Thr Gln Ser Gly Gly Ser Tyr Ala 
        115                 120                 125             


Cys Lys Arg Gly Ser Val Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


Tyr Glu Ser Glu Tyr Lys Tyr Pro Ala Leu Asn Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Gly Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Ser 
                165                 170                 175     


Thr Asp Lys Glu Gln Thr Asn Leu Tyr Val Arg Ala Ser Gly Arg Val 
            180                 185                 190         


Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Trp Val Arg Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Thr Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Thr Cys Ser Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Lys Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Lys Thr Arg Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 46
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Ile Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Ser Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Phe Ser Thr Gly Glu Ile Cys Asn Asn Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Met Asp Cys Thr Leu Val Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Gly Phe Gln Asn Gly Thr Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Phe Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Ile Ala Ser Ser Gly Thr Leu Glu Phe Thr 
            100                 105                 110         


Asn Glu Gly Phe Asn Trp Ala Gly Val Thr Gln Asn Gly Gly Ser Ser 
        115                 120                 125             


Ala Cys Arg Arg Gly Ser Asp Ser Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Tyr Lys Leu Gly Asn Thr Tyr Pro Val Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Asp Asn Phe Asp Lys Leu Tyr Ile Trp Gly Ile His His Pro 
                165                 170                 175     


Ser Thr Asp Gln Glu Gln Thr Arg Leu Tyr Ala Arg Glu Ser Gly Arg 
            180                 185                 190         


Val Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Thr Ser Asn Val 
        195                 200                 205             


Gly Pro Arg Pro Trp Val Arg Gly Leu Ser Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Asn Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Met Arg Ala Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Ser Thr Cys Ile Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Asn Val Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Lys Ile Thr Tyr Gly Ala Cys Pro Lys Tyr Ile Arg Gln Lys Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Lys Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Thr Ala Ile Asp Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Val Ile Glu Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Arg Arg Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Ile Gly Asn Gly Cys Phe Lys Ile Tyr His Arg Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asn His Asn 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Arg Gly Val 
                485                 490                 495     


Glu Leu Lys Ser 
            500 


<210> 47
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Arg Ile Cys Asp Ser Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Gly Phe Gln Asn Lys Glu Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Thr 
            100                 105                 110         


Asn Glu Gly Asn Trp Thr Gly Val Ala Gln Asp Gly Thr Ser Tyr Ala 
        115                 120                 125             


Cys Lys Arg Gly Ser Val Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


His Lys Leu Glu Tyr Lys Tyr Pro Ala Leu Asn Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Asp Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Ser 
                165                 170                 175     


Thr Asp Ser Val Gln Thr Ser Leu Tyr Val Gln Ala Ser Gly Arg Val 
            180                 185                 190         


Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Trp Val Arg Gly Ile Ser Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Asn Cys Asn Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Arg Thr Arg Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 48
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Arg Ile Cys Asp Ser Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Gly Phe Gln Asn Lys Glu Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Ser Asn Trp Thr Gly Val Ala Gln Asn Gly Thr Ser Tyr Ala 
        115                 120                 125             


Cys Lys Arg Ser Ser Ile Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


His Gln Leu Lys Tyr Lys Tyr Pro Ala Leu Asn Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Asp Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Ser 
                165                 170                 175     


Thr Asp Ser Asp Gln Thr Ser Ile Tyr Ala Gln Ala Ser Gly Arg Val 
            180                 185                 190         


Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Trp Val Arg Gly Ile Ser Ser Arg Ile Ser Ile His Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Arg Thr Arg Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 49
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Ile Ala Met Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Val Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Lys Ile Cys Asn His Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Met Asp Cys Thr Leu Ile Asp Ser Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Ser Phe Gln Asn Glu Thr Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Arg Ala Phe Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Ile 
            100                 105                 110         


Asn Glu Asp Phe Asn Trp Ala Glu Val Thr Gln Asn Gly Gly Ser Ser 
        115                 120                 125             


Ala Cys Lys Arg Gly Ser Asp Ser Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Tyr Lys Ser Gly Asn Thr Tyr Pro Thr Leu Asn Val Thr Ile Pro 
145                 150                 155                 160 


Asn Asn Gly Asn Phe Asp Lys Leu Tyr Ile Trp Gly Ile His His Pro 
                165                 170                 175     


Ser Thr Thr Lys Glu Gln Thr Arg Leu Tyr Val Gln Glu Ser Gly Lys 
            180                 185                 190         


Val Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Val 
        195                 200                 205             


Gly Pro Arg Pro Trp Val Arg Gly Leu Ser Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Leu Leu Leu Ile Ser Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Arg Leu Arg Ala Gly Lys Ser 
                245                 250                 255     


Ser Ile Ile Arg Ser Glu Ala Pro Ile Gly Thr Cys Ile Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Lys Ile Thr Tyr Gly Ala Cys Pro Lys Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Lys Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Val Ile Asp Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Ile Ile Glu Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Val Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Ile Ala Leu Glu Asn Gln His Thr Ile Asp Leu Ala Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Arg Arg Leu Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Ile Gly Asn Gly Cys Leu Lys Ile Tyr His Arg Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asn His Asp 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Ile 
                485                 490                 495     


Glu Leu Lys Ser 
            500 


<210> 50
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Asp Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Asn Phe Ser Met Gly Lys Ile Cys Asn Asn Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Ala Asn Cys Ser Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Asp Leu Gln Asn Glu Lys Trp Asp Leu Phe Ile Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Phe Ser Asn Cys Tyr Pro Tyr Asp Val Pro Glu Tyr 
                85                  90                  95      


Thr Ser Leu Arg Ser Leu Ile Ala Ser Ser Gly Thr Leu Glu Phe Thr 
            100                 105                 110         


Asn Glu Gly Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Gly Ser Ser 
        115                 120                 125             


Ala Cys Lys Arg Gly Pro Asn Asn Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Tyr Lys Ser Gly Asn Thr Tyr Pro Ile Leu Asn Val Thr Met Gln 
145                 150                 155                 160 


Asn Ser Asp Asp Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Ser Thr Asp Arg Glu Gln Thr Asn Leu Tyr Val Gln Ala Ser Gly Lys 
            180                 185                 190         


Val Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Ile Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Trp Ile Arg Gly Leu Ser Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Met Ile Asn Ser Asn Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Val Tyr Thr Gly Arg Ser 
                245                 250                 255     


Ser Ile Met Lys Ser Asp Ala Pro Leu Asp Thr Cys Asn Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Lys Ile Thr Tyr Gly Ala Cys Pro Lys Tyr Ile Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Ile Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asn Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Ile Ile Glu Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Arg Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ser Cys Met Glu Ser Ile Arg Asn Gly Thr Tyr Asp His Asn 
465                 470                 475                 480 


Glu Tyr Arg Asn Glu Ala Leu Ser Asn Arg Phe Gln Ile Lys Ser Val 
                485                 490                 495     


Glu Leu Lys Ser 
            500 


<210> 51
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Gly Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Ser Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser Ser Ala 
        115                 120                 125             


Cys Lys Arg Arg Ser Asn Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


Thr His Leu Lys Tyr Lys Tyr Pro Ala Leu Asn Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Glu Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val Leu His Pro Gly 
                165                 170                 175     


Thr Asp Ser Asp Gln Ile Arg Leu Tyr Ala Gln Ala Ser Gly Arg Ile 
            180                 185                 190         


Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Arg Val Arg Asp Val Ser Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Ile Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln Tyr Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 52
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Gly Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Ser Asn Trp Ala Gly Val Thr Gln Asn Gly Thr Ser Ser Ala 
        115                 120                 125             


Cys Lys Arg Arg Ser Asn Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


Thr His Leu Lys Tyr Lys Tyr Pro Ala Leu Asn Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Glu Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Gly 
                165                 170                 175     


Thr Asp Ser Asp Gln Ile Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile 
            180                 185                 190         


Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Arg Val Arg Asp Val Ser Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Glu Ser Ile Arg Asn Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 53
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Gly Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Ser Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser Ser Ser 
        115                 120                 125             


Cys Lys Arg Arg Ser Asn Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


Thr His Leu Lys Phe Lys Tyr Pro Ala Leu Asn Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Glu Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Gly 
                165                 170                 175     


Thr Asn Asn Asp Gln Ile Ser Leu Tyr Thr Gln Ala Ser Gly Arg Ile 
            180                 185                 190         


Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Arg Val Arg Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Ile Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 54
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Gln Thr Ile Thr Asp Asp Gln Val Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Val Gly Arg Ile Cys Asn Ser Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Gly Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Ala Phe Gln Asn Glu Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Phe Ser Asn Cys Tyr Pro Tyr Asp Met Gln Asp Tyr 
                85                  90                  95      


Val Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Thr 
            100                 105                 110         


Asn Glu Gly Phe Asn Trp Thr Gly Val Thr Gln Ser Gly Gly Ser Tyr 
        115                 120                 125             


Ala Cys Lys Arg Gly Ser Gly Asn Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Tyr Gln Ser Glu Asn Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Gly Asn Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Ser Thr Asp Arg Glu Gln Thr Asn Leu Tyr Val Arg Gly Ser Gly Arg 
            180                 185                 190         


Val Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Pro Gly Pro Trp Val Arg Gly Leu Ser Ser Arg Met Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Thr Leu Leu Ile Thr Ser Asn Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile His Ala Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Thr Cys Ser Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Lys Ile Thr Tyr Gly Ala Cys Pro Lys Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Ile Pro Glu Lys Gln Asn Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Val Ile Glu Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Val Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Arg Arg Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Thr Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp 
465                 470                 475                 480 


Ile Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Asp Val 
                485                 490                 495     


Val Leu Lys Ser 
            500 


<210> 55
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (232)..(232)
<223> Any amino acid

<400> 55
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Glu Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser Ser 
        115                 120                 125             


Ala Cys Ile Arg Arg Ser Lys Asn Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Thr His Leu Asn Phe Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ala Ser Gly Arg 
            180                 185                 190         


Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Ala Ile Pro Asn Ile 
        195                 200                 205             


Gly Tyr Arg Pro Arg Val Arg Asn Ile Pro Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Xaa Ile Leu Leu Ile Asn Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Arg 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val 
                485                 490                 495     


Glu Leu Lys Ser 
            500 


<210> 56
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Glu Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Ser Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser Ser Ala 
        115                 120                 125             


Cys Ile Arg Arg Ser Asn Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


Thr His Leu Lys Phe Lys Tyr Pro Ala Leu Asn Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Glu Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Gly 
                165                 170                 175     


Thr Asp Asn Asp Gln Ile Phe Pro Tyr Ala Gln Ala Ser Gly Arg Ile 
            180                 185                 190         


Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Arg Val Arg Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Ile Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 57
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Glu Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser Ser 
        115                 120                 125             


Ala Cys Ile Arg Arg Ser Asn Asn Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Thr His Phe Lys Phe Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Gly Thr Asp Asn Asp Gln Ile Phe Leu Tyr Ala Gln Ala Ser Gly Arg 
            180                 185                 190         


Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Arg Val Arg Ile Pro Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Lys Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Arg Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 58
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Gly Glu Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Leu Ser Met Gly Lys Ile Cys Lys Asn Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Ala Asn Cys Thr Leu Met Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Gly Phe Gln Asn Glu Lys Trp Asp Leu Phe Ile Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Phe Ser Asn Cys Tyr Pro Tyr Asp Val Pro Glu Tyr 
                85                  90                  95      


Thr Ser Leu Arg Ser Ile Ile Ala Ser Ser Gly Thr Leu Glu Phe Phe 
            100                 105                 110         


Ser Glu Asn Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Gly Ser Asn 
        115                 120                 125             


Ser Cys Lys Arg Gly Pro Asn Ser Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Tyr Lys Ser Gly Asn Asn Tyr Pro Ile Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Ser Glu Gly Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Ser Thr Glu Asn Glu Gln Thr Asn Leu Tyr Ala Gln Ala Pro Gly Lys 
            180                 185                 190         


Ile Thr Val Ser Thr Arg Ser Ser Gln Gln Thr Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Pro Arg Pro Trp Ile Arg Gly Leu Ser Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Met Ile Asn Ser Asn Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly His Phe Lys Val His Thr Gly Arg Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Asp Thr Cys Ser Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Lys Ile Thr Tyr Gly Val Cys Pro Lys Tyr Val Lys Gln Ser Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Ile Pro Glu Arg Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Val Ile Glu Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Arg Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Leu Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ser Cys Met Arg Ser Ile Arg Asn Gly Thr Tyr Asp His Asn 
465                 470                 475                 480 


Glu Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Ser Val 
                485                 490                 495     


Glu Leu Lys Leu 
            500 


<210> 59
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Glu Ile Cys Asn Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala His Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Ser Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser Ser Ala 
        115                 120                 125             


Cys Ile Arg Arg Ser Asn Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


Thr His Leu Asn Phe Lys Tyr Pro Ala Leu Asn Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Gly 
                165                 170                 175     


Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile 
            180                 185                 190         


Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Arg Val Arg Asp Ile Pro Ser Arg Val Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Ser Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Arg Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 60
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Lys Ile Cys Asn Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Glu Glu Phe Gln Asn Lys Glu Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Thr Ala Tyr Ser Asn Cys Tyr Pro Tyr Tyr Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Lys Phe Thr 
            100                 105                 110         


Lys Glu Asp Phe Asn Trp Thr Gly Val Ser Gln Asp Gly Ser Ser Phe 
        115                 120                 125             


Ser Cys Lys Arg Lys Ser Val Asn Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu His Lys Ser Thr Asn Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Ile Asp Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Ser Thr Asp Ser Asp Gln Ile Ser Leu Tyr Ala Gln Ala Ser Gly Arg 
            180                 185                 190         


Val Met Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Trp Val Arg Gly Val Ser Ser Ile Ile Ser Ile His 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Gly Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Glu Pro Ile Asp Asn Cys Asn Phe Asp Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asn Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Ser Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Val Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Arg Thr Arg Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val 
                485                 490                 495     


Glu Leu Lys Ser 
            500 


<210> 61
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Asp Asp Gln Val Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Asn Ser Ser Ala Gly Arg Ile Cys Asp Asn Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Ser Phe Lys Asn Lys Glu Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Glu Ala Tyr Ser Asp Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Asp Tyr Ile Arg Ser Ile Val Ala Ser Ser Gly Thr Leu Glu Phe Thr 
            100                 105                 110         


Asn Glu Ser Phe Asn Trp Thr Gly Val Ala Gln Asp Gly Thr Ser Asn 
        115                 120                 125             


Ser Cys Lys Arg Gly Ser Val Lys Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu His Lys Leu Glu Tyr Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Asp Arg Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Ser Thr Asp Ser Asp Gln Thr Asn Leu Tyr Val Gln Ala Ser Gly Lys 
            180                 185                 190         


Val Val Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Phe Arg Pro Trp Ile Arg Gly Ile Ser Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Thr Pro Ile Gly Asn Cys Asn Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Ile Lys Arg Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Val Glu Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Ile Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Ile Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asn 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val 
                485                 490                 495     


Lys Leu Lys Ser 
            500 


<210> 62
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Val Thr Asp Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Leu Ser Thr Gly Lys Ile Cys Asn Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Gly Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Arg Phe Gln Asn Arg Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Thr Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Ile Ala Ser Ser Gly Thr Leu Glu Phe Thr 
            100                 105                 110         


Lys Glu Asp Phe Asn Trp Thr Gly Val Ala Gln Asp Gly Ala Ser Tyr 
        115                 120                 125             


Ser Cys Lys Arg Gly Ser Val Lys Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu His Lys Leu Glu Tyr Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Asp Arg Phe Asn Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Ser Thr Asp Ser Asp Gln Thr Arg Leu Tyr Val Gln Ala Ser Gly Lys 
            180                 185                 190         


Val Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Pro Ile Pro Trp Ile Arg Gly Val Ser Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Asn Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Leu Arg Asn Gly Arg Ser 
                245                 250                 255     


Ser Val Met Arg Ser Asp Ala Pro Ile Asp Asn Cys Asn Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Thr Cys Pro Arg Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Thr Ala Ile Asn Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Val Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Arg Arg Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Ile Asn Gly Thr Tyr Asp His Asp 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val 
                485                 490                 495     


Glu Leu Lys Ser 
            500 


<210> 63
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Met Ala Met Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp His Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Met Gly Arg Ile Cys Asn Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Ala Phe Gln Asn Lys Glu Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Thr Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ala Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Asn Phe Asn Trp Thr Gly Val Ala Gln Asn Gly Ala Ser Thr 
        115                 120                 125             


Ala Cys Lys Arg Arg Ser Ser Asn Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Tyr Gln Leu Arg Tyr Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Glu Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Ser Thr Asp Asn Asp Gln Ile Ser Leu Tyr Ala Gln Ala Ser Gly Arg 
            180                 185                 190         


Val Ile Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Trp Val Arg Gly Val Ser Ser Thr Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Ala Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Asn Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asn Ala Pro Ile Gly Arg Cys Asn Ala Gly Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Ser Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Lys Thr 
    290                 295                 300                 


Leu Arg Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Ser Gln Ile 
        355                 360                 365             


Ser Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Ile 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Arg Thr Arg Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Glu Ser Ile Arg Asn Gly Thr Tyr Asp His Asp 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Ile 
                485                 490                 495     


Glu Leu Lys Ser 
            500 


<210> 64
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Arg Ile Cys Asp Ser Pro His Arg 
        35                  40                  45              


Ile Leu Asp Gly Lys Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro His Cys Asp Gly Phe Gln Asn Lys Glu Trp Asp Leu Phe Ile Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ser Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Thr 
            100                 105                 110         


Asn Glu Asp Phe Asn Trp Thr Gly Val Ala Gln Asp Gly Gly Ser Tyr 
        115                 120                 125             


Ser Cys Lys Arg Gly Ser Val Lys Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu His Lys Leu Glu Tyr Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Asp Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Ala Thr Asp Lys Asp Gln Ile Ser Leu Tyr Ala Gln Ala Ala Gly Arg 
            180                 185                 190         


Ile Ile Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Arg Val Arg Asp Ile Pro Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Arg Pro Gly Asp Ile Leu Leu Ile Asn Ser Pro Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Ala Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Lys Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Ala 
    290                 295                 300                 


Val Lys Leu Ala Thr Gly Met Arg Asn Arg Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val His Gly Trp Asp Gly Phe Thr His Gln Pro Ser Gly Gly Thr 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val 
                485                 490                 495     


Glu Leu Lys Ser 
            500 


<210> 65
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Ser Asn Trp Thr Gly Val Lys Gln Asn Gly Thr Ser Ser Ala 
        115                 120                 125             


Cys Ile Arg Lys Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


Thr His Leu Asn Tyr Thr Tyr Pro Ala Leu Asn Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Gly 
                165                 170                 175     


Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile 
            180                 185                 190         


Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Gln Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Arg Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asn Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu 
                485                 490                 495     


Leu Lys Ser 
            


<210> 66
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Ser Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln 
1               5                   10                  15      


Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp 
            20                  25                  30          


Ile Leu Glu Arg Thr His Asn Gly Lys Leu Cys Asp Leu Asn Gly Val 
        35                  40                  45              


Lys Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Ala Ser Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe 
                85                  90                  95      


Asn Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Ser His Phe 
            100                 105                 110         


Glu Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asn His Asp Ala 
        115                 120                 125             


Ser Ser Gly Val Ser Ser Ala Cys Pro Tyr Leu Gly Lys Ser Ser Phe 
    130                 135                 140                 


Phe Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr 
145                 150                 155                 160 


Ile Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu 
                165                 170                 175     


Trp Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr 
            180                 185                 190         


Gln Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln 
        195                 200                 205             


Arg Leu Val Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser 
    210                 215                 220                 


Gly Arg Ile Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile 
225                 230                 235                 240 


Asn Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys 
                245                 250                 255     


Ile Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr 
            260                 265                 270         


Gly Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ala Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala 
                325                 330                 335     


Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp 
            340                 345                 350         


Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp 
        355                 360                 365             


Gln Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn 
    370                 375                 380                 


Ser Ile Ile Asn Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu 
385                 390                 395                 400 


Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu 
                405                 410                 415     


Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
            420                 425                 430         


Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 
        435                 440                 445             


Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu 
    450                 455                 460                 


Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met 
465                 470                 475                 480 


Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu 
                485                 490                 495     


Ala Arg Leu Asn Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser 
            500                 505                 510     


<210> 67
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Ser Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Leu 
1               5                   10                  15      


Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp 
            20                  25                  30          


Ile Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val 
        35                  40                  45              


Lys Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Asn Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe 
            100                 105                 110         


Glu Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Pro Asn His Glu Ala 
        115                 120                 125             


Ser Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe 
    130                 135                 140                 


Phe Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Ala Tyr Pro Thr 
145                 150                 155                 160 


Ile Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu 
                165                 170                 175     


Trp Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr 
            180                 185                 190         


Gln Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln 
        195                 200                 205             


Arg Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser 
    210                 215                 220                 


Gly Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile 
225                 230                 235                 240 


Asn Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys 
                245                 250                 255     


Ile Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr 
            260                 265                 270         


Gly Asn Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Thr Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala 
                325                 330                 335     


Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp 
            340                 345                 350         


Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp 
        355                 360                 365             


Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn 
    370                 375                 380                 


Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu 
385                 390                 395                 400 


Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu 
                405                 410                 415     


Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
            420                 425                 430         


Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 
        435                 440                 445             


Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu 
    450                 455                 460                 


Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met 
465                 470                 475                 480 


Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu 
                485                 490                 495     


Ala Arg Leu Asn Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser 
            500                 505                 510     


<210> 68
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Ser Asp Gln Ile Cys Ile Gly Ser His Ala Asn Asn Ser Thr Glu Gln 
1               5                   10                  15      


Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp 
            20                  25                  30          


Ile Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val 
        35                  40                  45              


Lys Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Ala Ser Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Asn Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe 
            100                 105                 110         


Glu Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asn His Glu Ala 
        115                 120                 125             


Ser Ser Gly Val Ser Ser Ala Cys Pro Tyr Leu Gly Arg Pro Ser Phe 
    130                 135                 140                 


Phe Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Thr 
145                 150                 155                 160 


Ile Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu 
                165                 170                 175     


Trp Gly Ile His His Pro Asn Asp Glu Ala Glu Gln Ile Lys Leu Tyr 
            180                 185                 190         


Gln Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln 
        195                 200                 205             


Arg Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser 
    210                 215                 220                 


Gly Arg Met Glu Phe Phe Trp Ala Ile Leu Lys Pro Asn Asp Ala Ile 
225                 230                 235                 240 


Asn Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys 
                245                 250                 255     


Ile Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr 
            260                 265                 270         


Gly Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ala Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala 
                325                 330                 335     


Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp 
            340                 345                 350         


Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp 
        355                 360                 365             


Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn 
    370                 375                 380                 


Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Ile Gly Arg Glu 
385                 390                 395                 400 


Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu 
                405                 410                 415     


Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
            420                 425                 430         


Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 
        435                 440                 445             


Leu Tyr Glu Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Gly Leu 
    450                 455                 460                 


Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met 
465                 470                 475                 480 


Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu 
                485                 490                 495     


Ala Thr Leu Asn Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser 
            500                 505                 510     


<210> 69
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Ser Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln 
1               5                   10                  15      


Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp 
            20                  25                  30          


Ile Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val 
        35                  40                  45              


Lys Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Asn Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe 
            100                 105                 110         


Glu Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala 
        115                 120                 125             


Ser Leu Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe 
    130                 135                 140                 


Phe Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr 
145                 150                 155                 160 


Ile Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu 
                165                 170                 175     


Trp Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr 
            180                 185                 190         


Gln Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln 
        195                 200                 205             


Arg Leu Val Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser 
    210                 215                 220                 


Gly Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile 
225                 230                 235                 240 


Asn Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys 
                245                 250                 255     


Ile Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr 
            260                 265                 270         


Gly Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ser Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala 
                325                 330                 335     


Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp 
            340                 345                 350         


Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp 
        355                 360                 365             


Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn 
    370                 375                 380                 


Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu 
385                 390                 395                 400 


Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu 
                405                 410                 415     


Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
            420                 425                 430         


Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 
        435                 440                 445             


Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu 
    450                 455                 460                 


Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met 
465                 470                 475                 480 


Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu 
                485                 490                 495     


Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser 
            500                 505                 510     


<210> 70
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Ser Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln 
1               5                   10                  15      


Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp 
            20                  25                  30          


Ile Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val 
        35                  40                  45              


Lys Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe 
                85                  90                  95      


Asn Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe 
            100                 105                 110         


Glu Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala 
        115                 120                 125             


Ser Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Thr Pro Ser Phe 
    130                 135                 140                 


Phe Arg Asn Val Ile Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Thr 
145                 150                 155                 160 


Ile Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Ile Leu 
                165                 170                 175     


Trp Gly Ile His His Ser Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr 
            180                 185                 190         


Gln Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln 
        195                 200                 205             


Arg Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser 
    210                 215                 220                 


Gly Arg Met Asp Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile 
225                 230                 235                 240 


Asn Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys 
                245                 250                 255     


Ile Val Lys Lys Gly Asp Ser Ala Ile Leu Lys Ser Glu Val Glu Tyr 
            260                 265                 270         


Gly Asn Cys Asn Thr Lys Cys Gln Thr Pro Ile Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Lys Ser Asn Lys Leu Val Leu Ala Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ser Pro Leu Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala 
                325                 330                 335     


Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp 
            340                 345                 350         


Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp 
        355                 360                 365             


Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn 
    370                 375                 380                 


Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu 
385                 390                 395                 400 


Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu 
                405                 410                 415     


Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
            420                 425                 430         


Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 
        435                 440                 445             


Leu Tyr Asp Lys Val Arg Leu Gln Leu Lys Asp Asn Ala Lys Glu Leu 
    450                 455                 460                 


Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met 
465                 470                 475                 480 


Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu 
                485                 490                 495     


Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser 
            500                 505                 510     


<210> 71
<211> 510
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Ser Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln 
1               5                   10                  15      


Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp 
            20                  25                  30          


Ile Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asn Leu Asp Gly Val 
        35                  40                  45              


Lys Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Ile Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe 
                85                  90                  95      


Asn Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe 
            100                 105                 110         


Glu Lys Ile Gln Ile Ile Pro Lys Asn Ser Trp Ser Asp His Glu Ala 
        115                 120                 125             


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe 
    130                 135                 140                 


Arg Asn Val Val Trp Leu Thr Lys Arg Asp Asn Ala Tyr Pro Thr Ile 
145                 150                 155                 160 


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
            180                 185                 190         


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
        195                 200                 205             


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
    210                 215                 220                 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Ser Asn Asp Ala Ile Asn 
225                 230                 235                 240 


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Asn Ala Tyr Lys Ile 
                245                 250                 255     


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
            260                 265                 270         


Asn Cys Asn Thr Lys Cys Gln Thr Pro Ile Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
305                 310                 315                 320 


Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
                325                 330                 335     


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
            340                 345                 350         


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
        355                 360                 365             


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
    370                 375                 380                 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
385                 390                 395                 400 


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
                405                 410                 415     


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
            420                 425                 430         


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
        435                 440                 445             


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
    450                 455                 460                 


Asn Gly Cys Phe Glu Phe Tyr His Arg Cys Asp Asn Glu Cys Met Glu 
465                 470                 475                 480 


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
                485                 490                 495     


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser 
            500                 505                 510 


<210> 72
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Ser Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln 
1               5                   10                  15      


Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp 
            20                  25                  30          


Ile Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asn Leu Asp Gly Val 
        35                  40                  45              


Lys Pro Leu Ile Leu Lys Asp Cys Ser Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Met Cys Asp Glu Phe Leu Asn Val Ser Glu Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Ala Ser Pro Ala Asn Gly Leu Cys Tyr Pro Gly Asp Phe 
                85                  90                  95      


Asn Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Leu 
            100                 105                 110         


Lys Lys Ile Lys Ile Ile Pro Lys Ser Tyr Trp Ser Asn His Glu Ala 
        115                 120                 125             


Ser Ser Gly Val Ser Ala Ala Cys Ser Tyr Leu Gly Glu Pro Ser Phe 
    130                 135                 140                 


Phe Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Pro 
145                 150                 155                 160 


Ile Lys Val Asn Tyr Thr Asn Thr Asn Gln Glu Asp Leu Leu Val Leu 
                165                 170                 175     


Trp Gly Ile His His Pro Asn Asp Glu Lys Glu Gln Ile Arg Ile Tyr 
            180                 185                 190         


Gln Asn Pro Asn Thr Ser Ile Ser Val Gly Thr Ser Thr Leu Asn Gln 
        195                 200                 205             


Arg Leu Val Pro Lys Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser 
    210                 215                 220                 


Gly Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ser Ile 
225                 230                 235                 240 


Asn Phe Asp Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys 
                245                 250                 255     


Ile Ala Lys Lys Gly Asp Ser Val Ile Met Lys Ser Glu Leu Glu Tyr 
            260                 265                 270         


Gly Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ala Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala 
                325                 330                 335     


Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp 
            340                 345                 350         


Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp 
        355                 360                 365             


Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Ile Thr Asn Lys Val Asn 
    370                 375                 380                 


Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ile Val Gly Arg Glu 
385                 390                 395                 400 


Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu 
                405                 410                 415     


Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
            420                 425                 430         


Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 
        435                 440                 445             


Leu Tyr Glu Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu 
    450                 455                 460                 


Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met 
465                 470                 475                 480 


Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu 
                485                 490                 495     


Ala Arg Leu Ser Arg Glu Glu Ile Ser Gly Val Lys Met Glu Ser 
            500                 505                 510     


<210> 73
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Ser Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln 
1               5                   10                  15      


Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp 
            20                  25                  30          


Ile Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val 
        35                  40                  45              


Lys Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Ile Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe 
                85                  90                  95      


Asn Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe 
            100                 105                 110         


Glu Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala 
        115                 120                 125             


Ser Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe 
    130                 135                 140                 


Phe Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asp Ala Tyr Pro Thr 
145                 150                 155                 160 


Ile Lys Ile Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu 
                165                 170                 175     


Trp Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr 
            180                 185                 190         


Gln Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Leu 
        195                 200                 205             


Arg Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser 
    210                 215                 220                 


Gly Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile 
225                 230                 235                 240 


Asn Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Asn Ala Tyr Lys 
                245                 250                 255     


Ile Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr 
            260                 265                 270         


Gly Asn Cys Asn Thr Lys Cys Gln Thr Pro Val Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ser Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala 
                325                 330                 335     


Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp 
            340                 345                 350         


Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp 
        355                 360                 365             


Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn 
    370                 375                 380                 


Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu 
385                 390                 395                 400 


Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu 
                405                 410                 415     


Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
            420                 425                 430         


Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 
        435                 440                 445             


Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu 
    450                 455                 460                 


Gly Asn Gly Cys Phe Glu Phe Tyr His Arg Cys Asp Asn Glu Cys Met 
465                 470                 475                 480 


Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu 
                485                 490                 495     


Ser Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser 
            500                 505                 510     


<210> 74
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Ser Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln 
1               5                   10                  15      


Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp 
            20                  25                  30          


Ile Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val 
        35                  40                  45              


Arg Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Val Phe 
                85                  90                  95      


Asn Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe 
            100                 105                 110         


Glu Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Pro Ser His Glu Ala 
        115                 120                 125             


Ser Leu Gly Val Ser Ala Ala Cys Pro Tyr Gln Gly Gln Ser Ser Phe 
    130                 135                 140                 


Phe Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Thr 
145                 150                 155                 160 


Ile Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Met 
                165                 170                 175     


Trp Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr 
            180                 185                 190         


Gln Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln 
        195                 200                 205             


Arg Leu Thr Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser 
    210                 215                 220                 


Gly Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile 
225                 230                 235                 240 


Asn Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys 
                245                 250                 255     


Ile Val Lys Lys Gly Asp Ser Thr Ile Met Arg Ser Glu Leu Glu Tyr 
            260                 265                 270         


Gly Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Lys Ser Thr Arg Leu Val Leu Ala Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ser Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala 
                325                 330                 335     


Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp 
            340                 345                 350         


Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp 
        355                 360                 365             


Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn 
    370                 375                 380                 


Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu 
385                 390                 395                 400 


Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu 
                405                 410                 415     


Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
            420                 425                 430         


Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 
        435                 440                 445             


Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu 
    450                 455                 460                 


Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met 
465                 470                 475                 480 


Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu 
                485                 490                 495     


Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser 
            500                 505                 510     


<210> 75
<211> 510
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Ser Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln 
1               5                   10                  15      


Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp 
            20                  25                  30          


Ile Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asn Leu Asp Gly Val 
        35                  40                  45              


Lys Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly 
    50                  55                  60                  


Asn Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile 
65                  70                  75                  80  


Val Glu Lys Ile Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe 
                85                  90                  95      


Asn Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe 
            100                 105                 110         


Glu Lys Ile Gln Ile Ile Pro Lys Asp Ser Trp Ser Asp His Glu Ala 
        115                 120                 125             


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe 
    130                 135                 140                 


Arg Asn Val Val Trp Leu Thr Lys Lys Asn Asp Ala Tyr Pro Thr Ile 
145                 150                 155                 160 


Lys Lys Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
            180                 185                 190         


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
        195                 200                 205             


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
    210                 215                 220                 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Ser Asn Asp Ala Ile Asn 
225                 230                 235                 240 


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Asn Ala Tyr Lys Ile 
                245                 250                 255     


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Ser 
            260                 265                 270         


Asn Cys Asn Thr Lys Cys Gln Thr Pro Ile Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
305                 310                 315                 320 


Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
                325                 330                 335     


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
            340                 345                 350         


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
        355                 360                 365             


Glu Ser Thr Gln Arg Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
    370                 375                 380                 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
385                 390                 395                 400 


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
                405                 410                 415     


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
            420                 425                 430         


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
        435                 440                 445             


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
    450                 455                 460                 


Asn Gly Cys Phe Glu Phe Tyr His Arg Cys Asp Asn Glu Cys Met Glu 
465                 470                 475                 480 


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
                485                 490                 495     


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser 
            500                 505                 510 


<210> 76
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asn Cys Phe Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Met Gly Asn Thr Pro Ser Ala Lys 
65                  70                  75                  80  


Val Ser Ile Leu His Glu Val Lys Pro Ala Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Thr Ser Asn Val Ile Asn Thr Glu 
        115                 120                 125             


Thr Ala Pro Arg Gly Ser Tyr Lys Val Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Ala Asn Gly Asn Gly Phe Phe Asn Thr Met Ala Trp Val Ile 
145                 150                 155                 160 


Pro Lys Asp Asn Asn Lys Thr Ala Ile Asn Pro Val Thr Val Glu Val 
                165                 170                 175     


Pro Tyr Ile Cys Ser Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
            180                 185                 190         


His Ser Asp Asp Lys Thr Gln Met Glu Arg Leu Tyr Gly Asp Ser Asn 
        195                 200                 205             


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
    210                 215                 220                 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Glu Gly Leu Lys 
225                 230                 235                 240 


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys 
                245                 250                 255     


Thr Gly Thr Ile Val Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
            260                 265                 270         


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
        275                 280                 285             


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
    290                 295                 300                 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
305                 310                 315                 320 


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
                325                 330                 335     


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
        355                 360                 365             


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
    370                 375                 380                 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Tyr 
385                 390                 395                 400 


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
                405                 410                 415     


Asn Glu Leu His Asp Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
            420                 425                 430         


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
        435                 440                 445             


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
    450                 455                 460                 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
                485                 490                 495     


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Asp Phe Ser Leu Pro Thr 
            500                 505                 510         


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
        515                 520                 525             


Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535         


<210> 77
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Met Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Met Gly Thr Ile Pro Ser Ala Lys 
65                  70                  75                  80  


Val Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Thr Arg Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Thr Ala Pro Gly Gly Pro Tyr Thr Val Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Lys Gly Phe Phe Glu Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val 
                165                 170                 175     


Pro Tyr Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
            180                 185                 190         


His Ser Asp Asp Glu Thr Leu Met Val Ile Leu Tyr Gly Asp Ser Lys 
        195                 200                 205             


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
    210                 215                 220                 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Glu Gly Leu Lys 
225                 230                 235                 240 


Gln Ser Gly Arg Ile Val Val Asp Tyr Ile Val Gln Lys Pro Gly Lys 
                245                 250                 255     


Thr Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val 
            260                 265                 270         


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
        275                 280                 285             


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
    290                 295                 300                 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
305                 310                 315                 320 


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
                325                 330                 335     


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
        355                 360                 365             


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
    370                 375                 380                 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
385                 390                 395                 400 


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
                405                 410                 415     


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
            420                 425                 430         


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
        435                 440                 445             


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
    450                 455                 460                 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
                485                 490                 495     


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr 
            500                 505                 510         


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
        515                 520                 525             


Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535         


<210> 78
<211> 535
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Met Gly Asn Ile Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Lys Pro Gly Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Ala Arg Asn Val Thr Asn Ala Glu 
        115                 120                 125             


Thr Ala Pro Gly Gly Pro Tyr Ile Val Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
                165                 170                 175     


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
            180                 185                 190         


Asp Asp Glu Thr Gln Met Val Lys Leu Tyr Gly Asp Ser Lys Pro Gln 
        195                 200                 205             


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
    210                 215                 220                 


Ile Gly Gly Phe Pro Asn Gln Ala Glu Asp Glu Gly Leu Pro Gln Ser 
225                 230                 235                 240 


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
                245                 250                 255     


Thr Ile Ala Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
            260                 265                 270         


Ala Ser Gly Arg Arg Lys Val Ile Glu Gly Ser Leu Pro Leu Ile Gly 
        275                 280                 285             


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
    290                 295                 300                 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
305                 310                 315                 320 


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
                325                 330                 335     


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
        355                 360                 365             


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Phe Ser Leu Ser 
385                 390                 395                 400 


Glu Leu Glu Val Lys Asn Leu His Arg Leu Ser Gly Ala Met Asp Glu 
                405                 410                 415     


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
            420                 425                 430         


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
        435                 440                 445             


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
    450                 455                 460                 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
                485                 490                 495     


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
            500                 505                 510         


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
        515                 520                 525             


His Thr Ile Leu Leu Tyr Tyr 
    530                 535 


<210> 79
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Met Gly Thr Ile Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Ala Ala Pro Gly Gly Pro Tyr Ile Val Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Asn Asn Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu 
                165                 170                 175     


Val Pro Phe Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly 
            180                 185                 190         


Phe His Ser Asp Asn Glu Ile Gln Met Val Lys Leu Tyr Gly Asp Ser 
        195                 200                 205             


Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr 
    210                 215                 220                 


Val Ser Gln Ile Gly Gly Phe Pro Lys Gln Ala Glu Asp Gly Gly Leu 
225                 230                 235                 240 


Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly 
                245                 250                 255     


Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys 
            260                 265                 270         


Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro 
        275                 280                 285             


Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn 
    290                 295                 300                 


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
305                 310                 315                 320 


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
                325                 330                 335     


Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala 
            340                 345                 350         


Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp 
        355                 360                 365             


His Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp 
    370                 375                 380                 


Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn 
385                 390                 395                 400 


Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala 
                405                 410                 415     


Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp 
            420                 425                 430         


Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu 
        435                 440                 445             


Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
    450                 455                 460                 


Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile 
465                 470                 475                 480 


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
                485                 490                 495     


Asp Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro 
            500                 505                 510         


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly 
        515                 520                 525             


Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535             


<210> 80
<211> 536
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Met Cys Ile Gly Asn Ile Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Arg Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Ser Arg Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Arg Asp Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
                165                 170                 175     


Tyr Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
            180                 185                 190         


Ser Asp Asn Glu Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro 
        195                 200                 205             


Gln Lys Phe Thr Ser Ser Ala Asn Gly Ile Thr Thr His Tyr Val Ser 
    210                 215                 220                 


Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln 
225                 230                 235                 240 


Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr 
                245                 250                 255     


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
            260                 265                 270         


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
        275                 280                 285             


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
    290                 295                 300                 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
305                 310                 315                 320 


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
                325                 330                 335     


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
        355                 360                 365             


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
385                 390                 395                 400 


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
                405                 410                 415     


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
            420                 425                 430         


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
        435                 440                 445             


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
    450                 455                 460                 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
                485                 490                 495     


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
            500                 505                 510         


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
        515                 520                 525             


Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535     


<210> 81
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Leu Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Lys 
65                  70                  75                  80  


Val Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Arg Ile Arg Leu Ser Asn His Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Lys Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Glu Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu 
                165                 170                 175     


Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly 
            180                 185                 190         


Phe His Ser Asp Asn Glu Ile Gln Met Val Lys Leu Tyr Gly Asp Ser 
        195                 200                 205             


Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr 
    210                 215                 220                 


Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Ile Glu Asp Gly Gly Leu 
225                 230                 235                 240 


Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly 
                245                 250                 255     


Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys 
            260                 265                 270         


Val Trp Cys Ala Ser Gly Arg Ser Lys Ile Ile Lys Gly Ser Leu Pro 
        275                 280                 285             


Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn 
    290                 295                 300                 


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
305                 310                 315                 320 


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
                325                 330                 335     


Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala 
            340                 345                 350         


Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp 
        355                 360                 365             


His Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp 
    370                 375                 380                 


Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn 
385                 390                 395                 400 


Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala 
                405                 410                 415     


Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp 
            420                 425                 430         


Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu 
        435                 440                 445             


Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
    450                 455                 460                 


Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile 
465                 470                 475                 480 


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
                485                 490                 495     


Asp Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro 
            500                 505                 510         


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly 
        515                 520                 525             


Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535             


<210> 82
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Ala Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Ala Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Thr Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Gly Pro Met Cys Val Gly Ile Thr Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Lys Ile Arg Leu Ser Ala Gln Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Lys Ala Pro Gly Gly Pro Tyr Lys Leu Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Arg Asp Asp Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val 
                165                 170                 175     


Pro His Ile Cys Ala Asn Glu Glu Asp Gln Ile Thr Val Trp Gly Phe 
            180                 185                 190         


His Ser Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn 
        195                 200                 205             


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Ile Thr Thr His Tyr Val 
    210                 215                 220                 


Ser Gln Ile Gly Gly Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro 
225                 230                 235                 240 


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys 
                245                 250                 255     


Thr Gly Thr Ile Val Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
            260                 265                 270         


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
        275                 280                 285             


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
    290                 295                 300                 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
305                 310                 315                 320 


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
                325                 330                 335     


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
        355                 360                 365             


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
    370                 375                 380                 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
385                 390                 395                 400 


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
                405                 410                 415     


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
            420                 425                 430         


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
        435                 440                 445             


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
    450                 455                 460                 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
                485                 490                 495     


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr 
            500                 505                 510         


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
        515                 520                 525             


Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535         


<210> 83
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu 
        115                 120                 125             


Asn Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asp Asn Asn Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val 
                165                 170                 175     


Pro Tyr Val Cys Lys Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
            180                 185                 190         


His Ser Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn 
        195                 200                 205             


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
    210                 215                 220                 


Ser Gln Ile Gly Gly Phe Pro Ala Gln Thr Glu Asp Gly Gly Leu Pro 
225                 230                 235                 240 


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Arg Lys 
                245                 250                 255     


Thr Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Arg Val 
            260                 265                 270         


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
        275                 280                 285             


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
    290                 295                 300                 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
305                 310                 315                 320 


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
                325                 330                 335     


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
        355                 360                 365             


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
    370                 375                 380                 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
385                 390                 395                 400 


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
                405                 410                 415     


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
            420                 425                 430         


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
        435                 440                 445             


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
    450                 455                 460                 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
                485                 490                 495     


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr 
            500                 505                 510         


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
        515                 520                 525             


Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535         


<210> 84
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu 
        115                 120                 125             


Lys Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val 
                165                 170                 175     


Pro Tyr Ile Cys Thr Glu Gly Glu Gly Gln Ile Thr Val Trp Gly Phe 
            180                 185                 190         


His Ser Asp Asn Lys Pro Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn 
        195                 200                 205             


Pro Gln Lys Phe Thr Ser Ser Ala Ser Gly Val Thr Thr His Tyr Val 
    210                 215                 220                 


Ser Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro 
225                 230                 235                 240 


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys 
                245                 250                 255     


Thr Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val 
            260                 265                 270         


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
        275                 280                 285             


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
    290                 295                 300                 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
305                 310                 315                 320 


Pro Ile Trp Val Ile Thr Pro Gln Lys Leu Ala Asn Gly Thr Thr Phe 
                325                 330                 335     


Ser Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
        355                 360                 365             


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
    370                 375                 380                 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
385                 390                 395                 400 


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
                405                 410                 415     


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
            420                 425                 430         


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
        435                 440                 445             


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
    450                 455                 460                 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
                485                 490                 495     


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr 
            500                 505                 510         


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
        515                 520                 525             


Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535         


<210> 85
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Ile Ser Pro Leu Val Asp 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Val Lys Gly Thr Arg 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Gln 
        115                 120                 125             


Lys Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Cys Ala Val 
145                 150                 155                 160 


Pro Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val 
                165                 170                 175     


Pro Tyr Ile Arg Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
            180                 185                 190         


His Ser Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn 
        195                 200                 205             


Pro Pro Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
    210                 215                 220                 


Ser Gln Thr Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro 
225                 230                 235                 240 


Pro Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys 
                245                 250                 255     


Thr Gly Thr Ile Ala Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val 
            260                 265                 270         


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
        275                 280                 285             


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
    290                 295                 300                 


Ser Lys Pro Pro His Thr Gly Glu His Thr Lys Ala Ile Gly Asn Cys 
305                 310                 315                 320 


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
                325                 330                 335     


Arg Pro Ser Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
        355                 360                 365             


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
    370                 375                 380                 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
385                 390                 395                 400 


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
                405                 410                 415     


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
            420                 425                 430         


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
        435                 440                 445             


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
    450                 455                 460                 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
                485                 490                 495     


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Phe Leu Pro Thr 
            500                 505                 510         


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
        515                 520                 525             


Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535         


<210> 86
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 86
Asp Arg Ile Cys Thr Glu Ile Thr Ser Ser Asn Ser Pro Leu Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu 
        115                 120                 125             


Lys Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val 
                165                 170                 175     


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
            180                 185                 190         


His Ser Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn 
        195                 200                 205             


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
    210                 215                 220                 


Ser Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro 
225                 230                 235                 240 


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys 
                245                 250                 255     


Thr Gly Pro Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val 
            260                 265                 270         


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
        275                 280                 285             


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
    290                 295                 300                 


Ser Lys Tyr Ser His Thr Gly Asp His Ala Lys Thr Leu Gly Asn Cys 
305                 310                 315                 320 


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
                325                 330                 335     


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
        355                 360                 365             


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
    370                 375                 380                 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
385                 390                 395                 400 


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
                405                 410                 415     


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
            420                 425                 430         


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
        435                 440                 445             


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
    450                 455                 460                 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
                485                 490                 495     


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr 
            500                 505                 510         


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
        515                 520                 525             


Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535         


<210> 87
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Thr Gly Thr Thr Pro Ser Ala Arg 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Leu His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Asp Lys Asn Lys Thr Ala Thr Asn Pro Leu Ser Val Glu 
                165                 170                 175     


Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly 
            180                 185                 190         


Phe His Ser Asp Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser 
        195                 200                 205             


Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Ala Thr His Tyr 
    210                 215                 220                 


Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu 
225                 230                 235                 240 


Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly 
                245                 250                 255     


Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Arg 
            260                 265                 270         


Gly Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro 
        275                 280                 285             


Leu Phe Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn 
    290                 295                 300                 


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
305                 310                 315                 320 


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
                325                 330                 335     


Tyr Arg Pro Pro Ala Lys Leu Phe Lys Glu Arg Gly Phe Phe Gly Ala 
            340                 345                 350         


Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp 
        355                 360                 365             


His Gly Tyr Thr Ser His Gly Ala His Gly Val Pro Val Ala Ala Asp 
    370                 375                 380                 


Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn 
385                 390                 395                 400 


Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala 
                405                 410                 415     


Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp 
            420                 425                 430         


Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu 
        435                 440                 445             


Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
    450                 455                 460                 


Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile 
465                 470                 475                 480 


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
                485                 490                 495     


Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro 
            500                 505                 510         


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly 
        515                 520                 525             


Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535             


<210> 88
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
His Ser Ile Gln Thr Arg Asp Gln Asn His Pro Glu Thr Cys Asn Gln 
1               5                   10                  15      


Ser Ile Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val 
            20                  25                  30          


Asn Ile Ser Asn Ala Asn Ile Val Ala Gly Gln Asp Ala Thr Ser Met 
        35                  40                  45              


Ile Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Ser Arg Trp Ala Ile 
    50                  55                  60                  


Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Ile Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile 
        115                 120                 125             


Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Met Ser Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Lys Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Phe Lys Ile Glu 
    210                 215                 220                 


Lys Gly Arg Ile Ile Lys Ser Ile Glu Leu Asn Ala Pro Asn Tyr His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Ser Lys Val Met Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asp 
            260                 265                 270         


Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Ser Asn Asp Gly Thr Gly Ser Cys Gly Pro Val Ser 
    290                 295                 300                 


Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Arg Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Ser Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp Ser Ser Phe 
            340                 345                 350         


Ser Val Lys Gln Asp Ile Val Ala Ile Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Gln Pro Lys Glu Asn Thr 
385                 390                 395                 400 


Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp 
                405                 410                 415     


Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile 
            420                 425                 430         


Asp Lys 
        


<210> 89
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile Cys Asn Gln 
1               5                   10                  15      


Asn Ile Ile Thr Tyr Lys Asn Ser Thr Trp Val Asn Gln Thr Tyr Val 
            20                  25                  30          


Asn Ile Ser Asn Thr Asn Val Val Ala Gly Gln Asp Thr Thr Ser Val 
        35                  40                  45              


Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile Arg Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Arg His Ser Asn Gly 
            100                 105                 110         


Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser Cys Pro Val 
        115                 120                 125             


Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Lys Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asn Gly Leu Ala Ser Tyr Lys Ile Phe Lys Ile Glu 
    210                 215                 220                 


Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala Pro Asn Ser His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys Val Met Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asp 
            260                 265                 270         


Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Lys Asp Gly Thr Gly Ser Cys Gly Pro Val Tyr 
    290                 295                 300                 


Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr Arg Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Ser Ser Arg His Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp Ser Lys Phe 
            340                 345                 350         


Ser Val Arg Gln Asp Val Val Ala Met Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Met Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Asn Thr 
385                 390                 395                 400 


Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp 
                405                 410                 415     


Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile 
            420                 425                 430         


Asp Lys 
        


<210> 90
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Thr Cys Asn Gln 
1               5                   10                  15      


Ser Ile Ile Thr Tyr Lys Asn Ser Thr Trp Val Asn Gln Thr Tyr Val 
            20                  25                  30          


Asn Ile Ser Asn Thr Asn Val Val Ala Gly Lys Asp Thr Thr Ser Val 
        35                  40                  45              


Ile Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Arg Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Ser Lys Asp Asn Gly Val Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser Cys Pro Val 
        115                 120                 125             


Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asp Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Glu Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Gly Gly Pro Ala Ser Tyr Lys Ile Phe Lys Ile Glu 
    210                 215                 220                 


Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asp Ala Pro Asn Ser His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys Val Met Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asp 
            260                 265                 270         


Gln Asn Leu Asp Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Lys Asp Gly Lys Gly Asn Cys Gly Pro Val Tyr 
    290                 295                 300                 


Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr Arg Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Ser Ser Arg Gln Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp Ser Asn Phe 
            340                 345                 350         


Phe Val Lys Gln Asp Val Val Ala Val Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Met Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Lys Thr 
385                 390                 395                 400 


Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp 
                405                 410                 415     


Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile 
            420                 425                 430         


Asp Lys 
        


<210> 91
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile Cys Asn Gln 
1               5                   10                  15      


Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn Gln Thr Tyr Val 
            20                  25                  30          


Asn Ile Asn Asn Thr Asn Val Val Ala Gly Lys Asp Thr Thr Ser Val 
        35                  40                  45              


Thr Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Arg Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser Cys Pro Ile 
        115                 120                 125             


Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asp Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Arg Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Val Cys Ile Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asn Gly Pro Ala Ser Tyr Arg Ile Phe Lys Ile Glu 
    210                 215                 220                 


Lys Gly Lys Ile Thr Lys Ser Ile Glu Leu Asp Ala Pro Asn Ser His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Thr Val Met Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn 
            260                 265                 270         


Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Lys Asp Gly Lys Gly Ser Cys Gly Pro Val Thr 
    290                 295                 300                 


Val Asp Gly Ala Asp Gly Val Lys Gly Phe Ser Tyr Arg Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Ser Ser Arg Lys Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Asp Thr Asp Ser Asn Phe 
            340                 345                 350         


Leu Val Lys Gln Asp Val Val Ala Met Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Met Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Arg Glu Lys Thr 
385                 390                 395                 400 


Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser 
                405                 410                 415     


Asp Thr Val Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr 
            420                 425                 430         


Ile Asp Lys 
        435 


<210> 92
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
His Ser Ile Gln Ile Gly Thr Gln Asn Gln Pro Glu Thr Cys Asn Gln 
1               5                   10                  15      


Ser Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val 
            20                  25                  30          


Asn Ile Ser Asn Thr Asn Phe Val Ala Glu Gln Thr Val Val Ser Val 
        35                  40                  45              


Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Val 
        115                 120                 125             


Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Thr Ser Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Val Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Phe Lys Ile Glu 
    210                 215                 220                 


Arg Gly Lys Val Val Lys Ser Val Glu Leu Asn Ala Pro Asn Tyr His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Gly Glu Ile Thr Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn 
            260                 265                 270         


Gln Asn Leu Glu Tyr Lys Ile Gly Tyr Ile Cys Ser Gly Ile Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Asn Asp Arg Thr Gly Ser Cys Gly Pro Val Phe 
    290                 295                 300                 


Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Thr Ser Ser Arg Ser Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Asn Phe 
            340                 345                 350         


Ser Val Lys Gln Asp Ile Val Gly Ile Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Met Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Asn Thr 
385                 390                 395                 400 


Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Thr Ser Asp 
                405                 410                 415     


Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile 
            420                 425                 430         


Asp Lys 
        


<210> 93
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 93
His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile Cys Asn Gln 
1               5                   10                  15      


Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn His Thr Tyr Val 
            20                  25                  30          


Asn Ile Asn Asn Thr Asn Val Val Ala Gly Lys Asp Lys Thr Ser Val 
        35                  40                  45              


Thr Leu Ala Gly Asn Ser Ser Leu Cys Ser Ile Ser Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Thr Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser Cys Pro Leu 
        115                 120                 125             


Gly Glu Ala Pro Ser Pro Tyr Asn Ser Lys Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Glu Thr Ile Lys Ser Trp Lys Lys Arg Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Val Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asn Gly Ala Ala Ser Tyr Lys Ile Phe Lys Ile Glu 
    210                 215                 220                 


Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala Pro Asn Ser His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Thr Val Met Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn 
            260                 265                 270         


Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Lys Asp Gly Glu Gly Ser Cys Asn Pro Val Thr 
    290                 295                 300                 


Val Asp Gly Ala Asp Gly Val Lys Gly Phe Ser Tyr Arg Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Arg Leu Arg Lys Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Asp Thr Asp Ser Asp Phe 
            340                 345                 350         


Ser Val Lys Gln Asp Val Val Ala Met Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Val Arg Gly Arg Pro Arg Glu Asn Thr 
385                 390                 395                 400 


Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser 
                405                 410                 415     


Asp Thr Ala Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr 
            420                 425                 430         


Ile Asp Lys 
        435 


<210> 94
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile Cys Asn Gln 
1               5                   10                  15      


Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn Gln Thr Tyr Val 
            20                  25                  30          


Asn Ile Asn Asn Thr Asn Val Val Ala Gly Lys Asp Lys Thr Ser Met 
        35                  40                  45              


Thr Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Arg Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Thr Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Val Lys Asn Arg Ser Pro Tyr Arg Ala Leu Met Ser Cys Pro Leu 
        115                 120                 125             


Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Leu Gly Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Glu Thr Ile Lys Ser Trp Lys Lys Arg Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Val Cys Met Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asp Gly Ala Ala Ser Tyr Arg Ile Phe Lys Ile Glu 
    210                 215                 220                 


Lys Gly Arg Val Ile Lys Ser Ile Glu Leu Asp Ala Pro Asn Tyr His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Thr Val Met Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn 
            260                 265                 270         


Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Leu Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Lys Asp Gly Glu Gly Ser Cys Asn Pro Val Thr 
    290                 295                 300                 


Ala Asp Gly Ala Asp Gly Val Lys Gly Phe Ser Tyr Arg Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Arg Leu Arg Lys Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Asp Thr Asp Ser Asp Phe 
            340                 345                 350         


Ser Met Lys Gln Asp Ile Val Ala Met Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Met Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Val Arg Gly Leu Pro Arg Glu Asn Thr 
385                 390                 395                 400 


Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser 
                405                 410                 415     


Asp Thr Ala Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr 
            420                 425                 430         


Ile Asp Lys 
        435 


<210> 95
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 95
His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Val Cys Asn Gln 
1               5                   10                  15      


Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn His Thr Tyr Val 
            20                  25                  30          


Asn Ile Asn Asn Thr Asn Val Ile Val Gly Lys Asp Lys Thr Ser Val 
        35                  40                  45              


Thr Leu Ala Gly Asn Ser Ser Leu Cys Ser Ile Ser Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Thr Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser Cys Pro Leu 
        115                 120                 125             


Gly Glu Ala Pro Ser Pro Tyr Asn Ser Lys Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Glu Thr Ile Lys Ser Trp Lys Lys Gln Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Val Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asn Gly Ala Ala Ser Tyr Lys Ile Phe Lys Ile Glu 
    210                 215                 220                 


Lys Gly Lys Ile Thr Lys Ser Ile Glu Leu Asn Ala Pro Asn Phe His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Thr Val Met Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn 
            260                 265                 270         


Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Lys Asp Gly Glu Gly Ser Cys Asn Pro Val Thr 
    290                 295                 300                 


Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr Lys Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Arg Leu Arg Lys Gly Phe 
                325                 330                 335     


Glu Met Val Trp Asp Pro Asn Gly Trp Thr Asp Thr Asp Ser Asp Phe 
            340                 345                 350         


Ser Val Lys Gln Asp Val Val Ala Ile Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asn Cys Ile Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Val Arg Gly Leu Pro Lys Glu Asn Thr 
385                 390                 395                 400 


Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser 
                405                 410                 415     


Asp Thr Ala Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr 
            420                 425                 430         


Ile Asp Lys 
        435 


<210> 96
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
His Ser Ile Gln Thr Gly Trp Lys Asn His Thr Glu Thr Cys Ile Gln 
1               5                   10                  15      


Asn Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val 
            20                  25                  30          


Asn Ile Ser Asn Thr Lys Thr Val Thr Gly Gln Gly Val Ala Ser Thr 
        35                  40                  45              


Met Val Ala Gly Asn Ser Ser Leu Cys Pro Ile Asn Gly Trp Ala Val 
    50                  55                  60                  


Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Ile Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Asn Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Arg His Ser Asn Gly 
            100                 105                 110         


Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile 
        115                 120                 125             


Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Val Gly Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Lys Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Val Cys Ile Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asn Glu Gln Ala Ser Tyr Lys Val Phe Lys Ile Glu 
    210                 215                 220                 


Lys Gly Lys Ile Ile Lys Thr Ile Glu Leu Asp Ala Pro Asn Tyr His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Ser Lys Val Met Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Ala Ser Asn Arg Pro Trp Val Ser Phe Asp 
            260                 265                 270         


Gln Asn Leu Asn Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Ser Asn Asp Gly Lys Gly Ser Cys Gly Pro Val Pro 
    290                 295                 300                 


Ser Ser Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Arg Tyr Gly Ser 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Ser Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp Ser Ser Phe 
            340                 345                 350         


Ser Met Lys Gln Asp Ile Ile Ala Leu Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Met Asp Cys Ile Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Gln Pro Lys Glu Ser Thr 
385                 390                 395                 400 


Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Glu 
                405                 410                 415     


Thr Ala Ser Trp Ser Trp Pro Asp Gly Ala Asp Leu Pro Phe Thr Ile 
            420                 425                 430         


Asp Lys 
        


<210> 97
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 97
His Ser Ile Gln Thr Gly Ser Gln Asn Ser Thr Gly Ile Cys Asn Gln 
1               5                   10                  15      


Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn His Thr Tyr Val 
            20                  25                  30          


Asn Ile Asn Asn Thr Asn Val Val Ala Gly Glu Asp Lys Thr Ser Val 
        35                  40                  45              


Thr Leu Val Gly Asn Ser Ser Leu Cys Ser Ile Ser Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Thr Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser Cys Pro Leu 
        115                 120                 125             


Gly Glu Ala Pro Ser Pro Tyr Asn Ser Lys Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Gly Thr Ile Lys Ser Trp Lys Lys Gln Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Val Cys Met Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asn Lys Ala Ala Ser Tyr Lys Ile Phe Lys Ile Glu 
    210                 215                 220                 


Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala Pro Asn Phe Tyr 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Ile Val Met Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn 
            260                 265                 270         


Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Glu Asp Gly Glu Gly Ser Cys Asn Pro Val Thr 
    290                 295                 300                 


Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr Lys Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Arg Leu Arg Lys Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Asn Thr Asp Ser Asp Phe 
            340                 345                 350         


Ser Val Lys Gln Asp Val Val Ala Ile Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Val Arg Gly Leu Pro Arg Glu Asn Thr 
385                 390                 395                 400 


Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser 
                405                 410                 415     


Asp Thr Ala Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr 
            420                 425                 430         


Ile Asp Lys 
        435 


<210> 98
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
His Ser Ile Gln Thr Glu Ser Gln Asn Lys Pro Glu Ile Cys Asn Gln 
1               5                   10                  15      


Asn Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val 
            20                  25                  30          


Thr Val Ser Asn Thr Asn Phe Val Ala Glu Gln Ala Val Ala Ser Val 
        35                  40                  45              


Lys Leu Val Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile 
        115                 120                 125             


Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Thr Ser Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Asp Thr Ile Lys Ser Trp Arg Lys Asn Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Val Phe Lys Ile Glu 
    210                 215                 220                 


Arg Gly Lys Val Val Lys Ser Val Glu Leu Asn Ala Pro Asn Tyr His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Glu Ser Ser Glu Ile Thr Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn 
            260                 265                 270         


Gln Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Ile Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Phe 
    290                 295                 300                 


Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Arg Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Thr Ser Ser Arg Met Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asp Gly Trp Ile Arg Thr Asp Asp Lys Phe 
            340                 345                 350         


Ser Val Lys Gln Asp Ile Ile Gly Ile Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Met Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Asn Thr 
385                 390                 395                 400 


Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp 
                405                 410                 415     


Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile 
            420                 425                 430         


Asp Lys 
        


<210> 99
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 99
His Ser Ile Gln Thr Gly Gly Lys Asn Tyr Ser Glu Met Cys Asn Gln 
1               5                   10                  15      


Asn Val Ile Thr Tyr Val Asn Asn Thr Trp Val Asn Arg Thr Tyr Val 
            20                  25                  30          


Asn Ile Ser Asn Thr Asn Val Ala Thr Val Gln Gly Val Asn Ser Ile 
        35                  40                  45              


Ile Leu Ser Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Lys Gly Asp Ile Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile 
        115                 120                 125             


Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Lys Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Val Cys Met Asn Gly Ser Cys Phe Thr Val Leu Thr 
        195                 200                 205             


Asp Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Leu Lys Val Glu 
    210                 215                 220                 


Lys Gly Lys Ile Ile Lys Ser Ile Glu Leu Asn Ala Pro Asn Tyr His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ala Gly Lys Val Met Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Ala Ser Asn Arg Pro Trp Val Ser Phe Asp 
            260                 265                 270         


Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Ser Asn Asp Gly Lys Gly Lys Cys Gly Pro Val Phe 
    290                 295                 300                 


Pro Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn 
305                 310                 315                 320 


Gly Ile Trp Ile Gly Arg Thr Lys Ser Ile Asn Ser Arg Arg Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp Ser Ser Phe 
            340                 345                 350         


Ser Met Lys Gln Asp Val Ile Ala Leu Thr Asp Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Met Asn Cys Ile Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Gln Pro Lys Glu Gly Thr 
385                 390                 395                 400 


Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Glu 
                405                 410                 415     


Thr Thr Ser Trp Ser Trp Pro Asp Gly Ala Asp Leu Pro Phe Thr Ile 
            420                 425                 430         


Asp Lys 
        


<210> 100
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 100
His Ser Ile Gln Ile Gly Ser Gln Ser Gln Ile Glu Thr Cys Asn Gln 
1               5                   10                  15      


Ser Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val 
            20                  25                  30          


Asn Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val Val Ser Val 
        35                  40                  45              


Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Phe Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
            100                 105                 110         


Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile 
        115                 120                 125             


Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu 
    210                 215                 220                 


Lys Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn 
            260                 265                 270         


Gln Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser 
    290                 295                 300                 


Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe 
            340                 345                 350         


Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr 
385                 390                 395                 400 


Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp 
                405                 410                 415     


Thr Ala Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile 
            420                 425                 430         


Asp Lys 
        


<210> 101
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 101
His Ser Ile Gln Leu Gly Ser Gln Asn Tyr Thr Lys Thr Cys Thr Gln 
1               5                   10                  15      


Ser Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val 
            20                  25                  30          


Asn Ile Ser Asn Thr Asn Leu Ala Val Gly Gln Ser Val Val Ser Ala 
        35                  40                  45              


Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile 
    50                  55                  60                  


Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe 
65                  70                  75                  80  


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr 
                85                  90                  95      


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Gln His Ser Asn Gly 
            100                 105                 110         


Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile 
        115                 120                 125             


Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
    130                 135                 140                 


Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
                165                 170                 175     


Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Val Cys Val Asn Gly Ser Cys Phe Thr Val Met Thr 
        195                 200                 205             


Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu 
    210                 215                 220                 


Lys Gly Lys Ile Val Lys Ser Val Glu Met Asn Ala Pro Asn Tyr His 
225                 230                 235                 240 


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn 
            260                 265                 270         


Gln Asn Leu Glu Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Ile Phe Gly 
        275                 280                 285             


Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser 
    290                 295                 300                 


Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn 
305                 310                 315                 320 


Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe 
                325                 330                 335     


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Asn Phe 
            340                 345                 350         


Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser 
        355                 360                 365             


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg 
    370                 375                 380                 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Asn Thr 
385                 390                 395                 400 


Val Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp 
                405                 410                 415     


Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile 
            420                 425                 430         


Asp Lys 
        


<210> 102
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 102
His Phe Lys Gln Tyr Glu Cys Asp Ser Pro Ala Ser Asn Gln Val Met 
1               5                   10                  15      


Pro Cys Glu Pro Ile Ile Ile Glu Arg Asn Ile Thr Glu Ile Val Tyr 
            20                  25                  30          


Leu Asn Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys Val Val Glu 
        35                  40                  45              


Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gln Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp His Gly Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asp Asn Lys His Ser Asn Asp 
            100                 105                 110         


Thr Ile His Asp Arg Ile Pro His Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Arg Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Ile Thr 
145                 150                 155                 160 


Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asp Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Gln Asn Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Arg Ala Asp Thr Arg Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Lys Ile Val His Ile Ser Pro Leu Ser Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Ile Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Val Val Asp Ile Asn Met 
            260                 265                 270         


Glu Asp Tyr Ser Ile Asp Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Asn Asp Asp Arg Ser Ser Asn Ser Asn Cys Lys Asn 
    290                 295                 300                 


Pro Asn Asn Glu Arg Gly Asn Gln Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asn Gly Asp Asp Val Trp Met Gly Arg Thr Ile Ser Lys Asp Leu Arg 
                325                 330                 335     


Ser Gly Tyr Glu Thr Phe Lys Val Ile Gly Gly Trp Ser Thr Pro Asn 
            340                 345                 350         


Ser Lys Ser Gln Ile Asn Arg Gln Val Ile Val Asp Ser Asp Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln Glu Thr Arg 
385                 390                 395                 400 


Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asn Ile Asn Phe Met 
            420                 425                 430         


Pro Ile 
        


<210> 103
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 103
His Phe Lys Gln His Glu Cys Asp Ser Pro Ser Ser Asn Gln Val Met 
1               5                   10                  15      


Leu Cys Glu Pro Ile Ile Ile Glu Arg Asn Ile Thr Glu Ile Val Tyr 
            20                  25                  30          


Leu Asn Asn Thr Thr Ile Glu Lys Glu Thr Cys Pro Lys Leu Val Glu 
        35                  40                  45              


Tyr Arg Asn Trp Ser Lys Pro Gln Cys Lys Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Gly Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asp Asn Lys His Ser Asn Asp 
            100                 105                 110         


Thr Ile His Asp Arg Ile Pro His Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Arg Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Val Thr 
145                 150                 155                 160 


Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asp Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Gln Asn Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Arg Ala Asp Thr Arg Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Lys Ile Val His Ile Ser Pro Leu Ser Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Asp Val Arg Cys Ile Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp Ile Asn Met 
            260                 265                 270         


Lys Asp Tyr Ser Ile Asp Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Asn Asp Asp Arg Ser Ser Lys Ser Asn Cys Arg Asn 
    290                 295                 300                 


Pro Asn Asn Glu Arg Gly Asn His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asn Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Lys Asp Leu Arg 
                325                 330                 335     


Ser Gly Tyr Glu Thr Phe Lys Val Ile Gly Gly Trp Ser Thr Pro Asn 
            340                 345                 350         


Ser Lys Ser Gln Ile Asn Arg Gln Val Ile Val Asp Ser Asp Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Glu Gln Glu Thr Arg 
385                 390                 395                 400 


Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asn Ile Asn Phe Met 
            420                 425                 430         


Pro Ile 
        


<210> 104
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 104
His Phe Lys Gln Tyr Glu Cys Asp Ser Pro Ala Asn Asn Gln Val Met 
1               5                   10                  15      


Pro Cys Glu Pro Ile Ile Ile Glu Arg Asn Ile Thr Glu Ile Val Tyr 
            20                  25                  30          


Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys Leu Val Glu 
        35                  40                  45              


Tyr Arg Asn Trp Ser Lys Pro Gln Cys Lys Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Gly Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asp Asn Lys His Ser Asn Asp 
            100                 105                 110         


Thr Ile His Asp Arg Ile Pro His Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Arg Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Val Thr 
145                 150                 155                 160 


Gly Asp Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr Asp Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Gln Asn Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Arg Ala Asp Thr Arg Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Lys Ile Val His Ile Ser Pro Leu Ser Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Ile Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Val Val Asp Ile Asn Val 
            260                 265                 270         


Lys Asp Tyr Ser Ile Asp Ser Arg Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Asn Asn Asp Lys Ser Ser Asn Ser Asn Cys Arg Asn 
    290                 295                 300                 


Pro Asn Asn Asp Lys Gly Asn His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Lys Asp Ser Arg 
                325                 330                 335     


Ser Gly Tyr Glu Thr Phe Lys Val Ile Gly Gly Trp Ser Thr Pro Asn 
            340                 345                 350         


Ser Lys Ser Gln Ile Asn Arg Gln Val Ile Val Asp Ser Asp Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Glu Gln Glu Thr Lys 
385                 390                 395                 400 


Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile Asn Leu Met 
            420                 425                 430         


Ser Ile 
        


<210> 105
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 105
His Phe Lys Gln Tyr Glu Cys Asp Ser Pro Ala Asn Asn Gln Val Met 
1               5                   10                  15      


Pro Cys Glu Pro Ile Ile Ile Glu Arg Asn Ile Thr Lys Ile Met Tyr 
            20                  25                  30          


Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys Ser Val Glu 
        35                  40                  45              


Tyr Arg Asn Trp Ser Lys Pro Gln Cys Lys Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Ala Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Gly Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asp Asn Lys His Ser Asn Asp 
            100                 105                 110         


Thr Ile His Asp Arg Thr Pro His Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Arg Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Val Thr 
145                 150                 155                 160 


Gly Tyr Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asp Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Gln Asn Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Lys Ile Val His Val Ser Pro Leu Ser Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Ile Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp Ile Asn Val 
            260                 265                 270         


Lys Asp Tyr Ser Ile Asp Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Asn Asn Asp Arg Ser Ser Asn Ser Tyr Cys Arg Asn 
    290                 295                 300                 


Pro Asn Asn Glu Arg Gly Asn His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Asp Asp Val Trp Met Gly Arg Thr Ile Ser Lys Asp Ser Arg 
                325                 330                 335     


Leu Gly Tyr Glu Thr Phe Lys Val Ile Gly Gly Trp Ser Thr Pro Asn 
            340                 345                 350         


Ser Lys Leu Gln Ile Asn Lys Gln Val Ile Val Asp Ser Asp Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Arg Gln Glu Thr Arg 
385                 390                 395                 400 


Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile Asn Leu Met 
            420                 425                 430         


Pro Ile 
        


<210> 106
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 106
His Phe Lys Gln Tyr Glu Cys Asn Ser Pro Pro Asn Asn Gln Val Met 
1               5                   10                  15      


Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu Ile Val Tyr 
            20                  25                  30          


Leu Thr Asn Thr Thr Ile Glu Lys Glu Lys Cys Pro Lys Leu Val Glu 
        35                  40                  45              


Tyr Arg Asn Trp Ser Lys Pro Gln Cys Lys Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Gly Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Arg His Ser Asn Asp 
            100                 105                 110         


Thr Val His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Val Thr 
145                 150                 155                 160 


Gly His Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr Asp Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Lys Asn Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Glu Arg Ala Asp Thr Lys Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Lys Ile Val His Ile Ser Pro Leu Ser Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Val Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp Ile Asn Val 
            260                 265                 270         


Lys Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser Tyr Cys Arg Asn 
    290                 295                 300                 


Pro Asn Asn Glu Lys Gly Ser His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Glu Glu Leu Arg 
                325                 330                 335     


Ser Gly Tyr Glu Thr Phe Lys Val Ile Gly Gly Trp Ser Thr Pro Asn 
            340                 345                 350         


Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Arg Gly Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln Glu Asn Lys 
385                 390                 395                 400 


Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile Asn Leu Met 
            420                 425                 430         


Pro Ile 
        


<210> 107
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 107
His Phe Lys Gln Tyr Glu Cys Asn Ser Pro Pro Asn Asn Gln Val Met 
1               5                   10                  15      


Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu Ile Val Tyr 
            20                  25                  30          


Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys Leu Ala Glu 
        35                  40                  45              


Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asn Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Gly His Ser Asn Asp 
            100                 105                 110         


Thr Val His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Val Thr 
145                 150                 155                 160 


Gly Asp Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr Asn Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Lys Lys Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Lys Ile Val His Thr Ser Pro Leu Ser Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Val Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp Ile Asn Val 
            260                 265                 270         


Lys Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His Cys Leu Asn 
    290                 295                 300                 


Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Glu Lys Leu Arg 
                325                 330                 335     


Ser Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser Lys Pro Asn 
            340                 345                 350         


Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Arg Gly Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln Glu Thr Glu 
385                 390                 395                 400 


Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile Asn Leu Met 
            420                 425                 430         


Pro Ile 
        


<210> 108
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 108
His Phe Lys Gln Tyr Glu Cys Asn Ser Pro Pro Asn Asn Gln Val Ile 
1               5                   10                  15      


Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu Ile Val Tyr 
            20                  25                  30          


Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys Leu Ala Glu 
        35                  40                  45              


Tyr Arg Asn Trp Ser Lys Pro Gln Cys Lys Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Arg His Ser Asn Asp 
            100                 105                 110         


Thr Val His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Val Thr 
145                 150                 155                 160 


Gly His Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr Asn Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Lys Lys Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Val Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Arg Ala Asp Thr Lys Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Gln Ile Val His Ile Ser Pro Leu Leu Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Val Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp Ile Asn Val 
            260                 265                 270         


Lys Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Lys Asn Asp Arg Ser Ser Ser Ser Asn Cys Leu Asn 
    290                 295                 300                 


Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Glu Lys Leu Arg 
                325                 330                 335     


Ser Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser Lys Pro Asn 
            340                 345                 350         


Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Arg Asp Asp Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln Glu Thr Glu 
385                 390                 395                 400 


Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Pro Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile Asn Leu Met 
            420                 425                 430         


Pro Ile 
        


<210> 109
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 109
His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn Gln Val Met 
1               5                   10                  15      


Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu Ile Val Tyr 
            20                  25                  30          


Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys Leu Ala Glu 
        35                  40                  45              


Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asp Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Arg Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Val His Ser Asn Asp 
            100                 105                 110         


Thr Val His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Val Thr 
145                 150                 155                 160 


Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Val Ser Trp Ser Lys Lys Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Lys Ile Val His Thr Ser Thr Leu Ser Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Val Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp Ile Asn Ile 
            260                 265                 270         


Lys Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His Cys Leu Asp 
    290                 295                 300                 


Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Glu Lys Leu Arg 
                325                 330                 335     


Ser Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser Asn Pro Asn 
            340                 345                 350         


Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Arg Gly Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu Glu Thr Glu 
385                 390                 395                 400 


Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile Asn Leu Met 
            420                 425                 430         


Pro Ile 
        


<210> 110
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 110
His Phe Lys Gln Tyr Glu Cys Asp Pro Pro Ala Asn Asn Gln Val Met 
1               5                   10                  15      


Thr Cys Lys Pro Ile Ile Ile Glu Arg Asn Thr Thr Glu Ile Val Tyr 
            20                  25                  30          


Leu Thr Asn Val Thr Ile Glu Lys Glu Thr Tyr Pro Lys Ile Val Glu 
        35                  40                  45              


Tyr Arg Asn Trp Ser Met Pro Gln Cys Lys Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Glu Pro Gly Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asp Asn Lys His Ser Asn Asp 
            100                 105                 110         


Thr Ile His Asp Arg Thr Pro His Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe Tyr Leu Gly Thr Arg Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys Tyr Asp Gly Lys Ala Trp Leu His Val Cys Ile Thr 
145                 150                 155                 160 


Gly His Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asp Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Met Asn Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Lys Ala Asp Thr Arg Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Lys Ile Ile His Ile Ser Pro Leu Ala Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Ile Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp Ile Asn Val 
            260                 265                 270         


Lys Asp Tyr Ser Ile Asp Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Asn Asn Asp Lys Ser Ser Ser Ser Tyr Cys Arg Asn 
    290                 295                 300                 


Pro Asn Asn Glu Lys Gly Gly His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Asn Asp Leu Trp Met Gly Arg Thr Ile Ser Glu Asp Ile Arg 
                325                 330                 335     


Ser Gly Tyr Glu Thr Phe Lys Val Ile Gly Gly Trp Ser Ile Pro Asn 
            340                 345                 350         


Ser Lys Leu Gln Val Asn Arg Gln Val Ile Val Asp Ser Asn Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Arg Thr Glu Ala Arg 
385                 390                 395                 400 


Val Gly Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Thr Trp Pro Asp Gly Ala Asp Ile Asn Leu Met 
            420                 425                 430         


Pro Ile 
        


<210> 111
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 111
His Phe Lys Gln Tyr Glu Cys Ser Ser Pro Ser Thr Asn Gln Val Arg 
1               5                   10                  15      


Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu Ile Val Tyr 
            20                  25                  30          


Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys Leu Ala Glu 
        35                  40                  45              


Tyr Arg Asp Trp Ser Lys Pro Gln Cys Lys Ile Lys Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Arg His Ser Asn Asp 
            100                 105                 110         


Thr Val His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Val Thr 
145                 150                 155                 160 


Gly His Asp Glu Asn Ala Thr Ala Ser Phe Ile Tyr Asn Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Lys Lys Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Arg Ala Asp Thr Lys Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Lys Ile Val His Ile Ser Gln Leu Ser Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Val Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp Ile Asn Val 
            260                 265                 270         


Lys Asp Arg Ser Ile Ala Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His Cys Leu Thr 
    290                 295                 300                 


Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Glu Lys Leu Arg 
                325                 330                 335     


Leu Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser Lys Pro Asn 
            340                 345                 350         


Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Lys Gly Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln Glu Thr Glu 
385                 390                 395                 400 


Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile Asn Leu Met 
            420                 425                 430         


Pro Ile 
        


<210> 112
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 112
His Phe Arg Gln Cys Glu Cys Asn Ser Ser Ala Ile Asn Gln Thr Met 
1               5                   10                  15      


Pro Cys Glu Pro Thr Lys Ile Glu Lys Asn Ile Thr Glu Ile Val Tyr 
            20                  25                  30          


Leu Thr Asn Thr Thr Ile Lys Thr Glu Val Cys Pro Lys Leu Val Lys 
        35                  40                  45              


Tyr Arg Asn Trp Ala Lys Pro Gln Cys Lys Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Ala Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Leu Ser Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asp Asn Arg His Ser Asn Asp 
            100                 105                 110         


Thr Ile His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Arg Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Val Thr 
145                 150                 155                 160 


Gly Tyr Asp Lys Asn Ala Thr Ala Ser Leu Ile Tyr Asp Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Gln Asn Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Lys Ala Asp Thr Arg Ile Leu Phe Val Glu Glu 
    210                 215                 220                 


Gly Lys Ile Ile His Ile Ser Pro Leu Thr Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Val Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Val Val Asp Ile Asn Val 
            260                 265                 270         


Lys Asp Tyr Lys Ile Asn Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asn Thr Pro Arg Asn Asn Asp Arg Ser Ser Asn Ser Asn Cys Gln Asn 
    290                 295                 300                 


Pro Asn Asn Gln Arg Gly Asn His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Asn Asp Ile Trp Met Gly Arg Thr Ile Ser Asn Asp Ser Arg 
                325                 330                 335     


Leu Gly Tyr Glu Thr Phe Lys Val Ile Gly Gly Trp Ser Lys Pro Asn 
            340                 345                 350         


Ser Lys Val Gln Thr Asn Arg Gln Val Ile Val Asp Ser Asp Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Val Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Arg Gln Glu Thr Arg 
385                 390                 395                 400 


Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Ser Gly Ser Trp Pro Asp Gly Ala Asp Ile Asn Leu Met 
            420                 425                 430         


Pro Ile 
        


<210> 113
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 113
His Phe Asn Gln Cys Asp Cys His Tyr Pro Pro Asn Asn Gln Val Thr 
1               5                   10                  15      


Leu Cys Glu Pro Thr Ile Thr Glu Arg Asn Thr Thr Lys Ile Val Tyr 
            20                  25                  30          


Leu Thr Asn Thr Thr Ile Glu Lys Glu Asn Cys Pro Lys Leu Ala Glu 
        35                  40                  45              


Tyr Arg Asp Trp Ser Lys Pro Gln Cys Lys Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Arg His Ser Asn Asp 
            100                 105                 110         


Thr Phe His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Ile Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Ile Thr 
145                 150                 155                 160 


Gly His Asp Glu Asn Ala Thr Ala Ser Ile Ile Tyr Asn Gly Arg Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Lys Lys Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Arg Ala Asp Thr Lys Ile Leu Phe Ile Glu Glu 
    210                 215                 220                 


Gly Lys Ile Ile His Ile Ser Pro Leu Ile Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Ile Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Val Val Asp Ile Asn Val 
            260                 265                 270         


Lys Asp Tyr Ser Ile Val Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Lys Asp Asp Lys Ser Ser Ser Ser Asn Cys Leu Asn 
    290                 295                 300                 


Pro Asn Asn Glu Lys Gly Glu His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Lys Asp Val Trp Met Gly Arg Thr Ile Asn Glu Thr Leu Arg 
                325                 330                 335     


Ser Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser Lys Ser Asn 
            340                 345                 350         


Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Glu Lys Ser Asp Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln Glu Thr Ala 
385                 390                 395                 400 


Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile Asn Leu Met 
            420                 425                 430         


Pro Val 
        


<210> 114
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 114
His Phe Glu Gln Tyr Asp Cys Asn Pro Phe Pro Asn Asn Gln Val Met 
1               5                   10                  15      


Leu Cys Lys Pro Thr Ile Ile Glu Arg Asn Thr Thr Glu Phe Val Tyr 
            20                  25                  30          


Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys Leu Ala Glu 
        35                  40                  45              


Tyr Arg Asn Trp Ala Lys Pro Gln Cys Thr Ile Thr Gly Phe Ala Pro 
    50                  55                  60                  


Phe Ser Arg Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp 
65                  70                  75                  80  


Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys Cys Tyr Gln 
                85                  90                  95      


Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Gly His Ser Asn Asp 
            100                 105                 110         


Thr Val His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met Asn Glu Leu 
        115                 120                 125             


Gly Val Pro Phe His Leu Gly Thr Arg Gln Val Cys Ile Ala Trp Ser 
    130                 135                 140                 


Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Ile Thr 
145                 150                 155                 160 


Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Gly Gly Lys Leu 
                165                 170                 175     


Val Asp Ser Ile Gly Ser Trp Ser Lys Asn Ile Leu Arg Thr Gln Glu 
            180                 185                 190         


Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val Met Thr Asp 
        195                 200                 205             


Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe Ile Lys Glu 
    210                 215                 220                 


Gly Lys Ile Val His Ile Ser Thr Leu Ser Gly Ser Ala Gln His Val 
225                 230                 235                 240 


Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Val Cys 
                245                 250                 255     


Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Val Val Asp Ile Asn Val 
            260                 265                 270         


Lys Asp Tyr Ser Ile Ala Ser Ser Tyr Val Cys Ser Gly Leu Val Gly 
        275                 280                 285             


Asp Thr Pro Arg Lys Asn Asp Ser Phe Ser Asn Ser His Cys Leu Asn 
    290                 295                 300                 


Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp Ala Phe Asp 
305                 310                 315                 320 


Asp Gly Ser Asp Val Trp Met Gly Arg Thr Ile Ser Glu Lys Phe Arg 
                325                 330                 335     


Leu Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser Arg Pro Asn 
            340                 345                 350         


Ser Lys Leu Gln Thr Asn Arg Gln Val Ile Val Glu Arg Gly Asn Arg 
        355                 360                 365             


Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser Cys Ile Asn 
    370                 375                 380                 


Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu Glu Thr Lys 
385                 390                 395                 400 


Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser Gly 
                405                 410                 415     


Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile Asn Ile Met 
            420                 425                 430         


Pro Ile 
        


<210> 115
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 115
His Leu Arg Gln Tyr Glu Phe Asn Ser Pro Pro Lys Asn Asn Gln Val 
1               5                   10                  15      


Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu Ile Val 
            20                  25                  30          


Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys Leu Ala 
        35                  40                  45              


Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asp Ile Thr Gly Phe Ala 
    50                  55                  60                  


Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly Asp Ile 
65                  70                  75                  80  


Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Gly Pro Asp Lys Cys Phe 
                85                  90                  95      


Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Val His Ser Asn 
            100                 105                 110         


Asp Thr Val His Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met Ser Glu 
        115                 120                 125             


Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile Ala Trp 
    130                 135                 140                 


Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val Cys Val 
145                 150                 155                 160 


Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Ile Ile Tyr Asn Gly Arg 
                165                 170                 175     


Leu Val Asp Ser Ile Val Ser Trp Ser Lys Lys Ile Leu Arg Thr Gln 
            180                 185                 190         


Glu Ser Glu Cys Val Cys Ile Asn Gly Ile Cys Thr Val Val Met Thr 
        195                 200                 205             


Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe Ile Glu 
    210                 215                 220                 


Glu Gly Lys Ile Val His Thr Ser Thr Leu Ser Gly Ser Ala Gln His 
225                 230                 235                 240 


Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg Cys Val 
                245                 250                 255     


Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp Ile Asn 
            260                 265                 270         


Ile Arg Asp Tyr Ser Ile Val Ser Asn Tyr Val Cys Ser Gly Leu Val 
        275                 280                 285             


Gly Asp Thr Pro Arg Lys Pro Asp Ser Ser Ser Ser Ser Asn Cys Leu 
    290                 295                 300                 


Asp Pro Asn Asp Glu Glu Gly Gly His Gly Val Lys Gly Trp Ala Phe 
305                 310                 315                 320 


Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Glu Lys Ser 
                325                 330                 335     


Arg Leu Gly Tyr Glu Thr Phe Lys Val Ile Gly Gly Trp Phe Asn Pro 
            340                 345                 350         


Asn Ser Lys Ser Gln Ile Asn Arg Gln Val Ile Val Asp Arg Gly Asn 
        355                 360                 365             


Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Asn Cys Ile 
    370                 375                 380                 


Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Asp Glu Ile 
385                 390                 395                 400 


Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly Thr Ser 
                405                 410                 415     


Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Leu Lys Leu 
            420                 425                 430         


Met Ser Val 
        435 


<210> 116
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 116
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Pro Thr Glu Ile Thr Ala 
1               5                   10                  15      


Pro Thr Met Pro Leu Gly Cys Ala Asn Ala Ser Asn Val Gln Ala Val 
            20                  25                  30          


Asn Arg Ser Ala Thr Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Asn Glu Cys 
                85                  90                  95      


Lys His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Gly Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Asn Asn Ala Leu Leu Lys Val Lys Tyr Gly 
                165                 170                 175     


Glu Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Asn Lys Ile Leu Arg 
            180                 185                 190         


Thr Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asn Cys Tyr Leu Met 
        195                 200                 205             


Ile Thr Asp Gly Ser Ala Ser Gly Val Ser Glu Cys Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val 
225                 230                 235                 240 


Lys His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Arg Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Ala Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Asp Thr Tyr Leu Asp Thr Pro Arg Pro Asn Asp Gly Ser Ile Thr Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asp Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Lys Ser Lys Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Glu Arg Met Gly Met Gly Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Ala Asp Ser Asp Ala Leu Ala Phe Ser Gly Val 
        355                 360                 365             


Met Val Ser Met Lys Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp 
            420                 425                 430         


Met Ala Leu 
        435 


<210> 117
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 117
Leu Tyr Ser Asp Val Leu Leu Lys Phe Ser Ser Thr Lys Thr Thr Ala 
1               5                   10                  15      


Pro Thr Met Ser Leu Glu Cys Thr Asn Ala Ser Asn Ala Gln Thr Val 
            20                  25                  30          


Asn His Ser Ala Thr Lys Glu Met Thr Phe Pro Pro Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Gln Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Ile Lys Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Val Ala Cys Gly Pro Lys Glu Cys 
                85                  90                  95      


Arg His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Lys Asp Arg Asn Lys Leu Arg His Leu Val Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Asn Asp Ala Leu Val Lys Ile Lys Tyr Gly 
                165                 170                 175     


Glu Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala His Asn Ile Leu Arg 
            180                 185                 190         


Thr Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met 
        195                 200                 205             


Ile Thr Asp Gly Ser Ala Ser Gly Ile Ser Lys Cys Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Lys Glu Ile Leu Pro Thr Gly Arg Val 
225                 230                 235                 240 


Glu His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Lys Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Ala Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asn Gly Asp Lys Trp Leu Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Asn Arg Met Gly Met Glu Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Thr Asp Ser Asp Ala Leu Thr Leu Ser Gly Val 
        355                 360                 365             


Met Val Ser Ile Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Asp Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp 
            420                 425                 430         


Met Ala Leu 
        435 


<210> 118
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 118
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Pro Thr Lys Arg Thr Ala 
1               5                   10                  15      


Pro Thr Met Ser Leu Glu Cys Val Asn Val Ser Asn Ala Gln Ala Val 
            20                  25                  30          


Asn His Ser Ala Thr Lys Glu Met Thr Phe Leu Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Gln Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Thr Arg Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Val Ala Cys Gly Pro Lys Glu Cys 
                85                  90                  95      


Arg His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Lys Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Ser Asp Ala Leu Ile Lys Ile Lys Tyr Gly 
                165                 170                 175     


Glu Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala His Asn Ile Leu Arg 
            180                 185                 190         


Thr Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met 
        195                 200                 205             


Ile Thr Asp Gly Ser Ala Ser Gly Ile Ser Lys Cys Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Ala Gly Arg Val 
225                 230                 235                 240 


Glu His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Glu Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asn Gly Asp Lys Gly Leu Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Glu Arg Met Gly Met Glu Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Thr Asp Ser Asp Ala Leu Ala Pro Ser Gly Val 
        355                 360                 365             


Met Val Ser Ile Lys Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp 
            420                 425                 430         


Met Ala Leu 
        435 


<210> 119
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 119
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Pro Thr Lys Ile Thr Ala 
1               5                   10                  15      


Pro Thr Met Ser Leu Asp Cys Ala Asn Val Ser Asn Val Gln Ala Val 
            20                  25                  30          


Asn Arg Ser Val Thr Lys Glu Met Thr Phe Leu Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Gln Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Thr Arg Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Val Ala Cys Gly Pro Lys Glu Cys 
                85                  90                  95      


Arg His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Asn Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Ser Asn Ala Leu Ile Lys Ile Lys Tyr Gly 
                165                 170                 175     


Glu Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg 
            180                 185                 190         


Thr Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Pro Met 
        195                 200                 205             


Ile Thr Asp Gly Ser Ala Ser Gly Ile Ser Lys Cys Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val 
225                 230                 235                 240 


Asp His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Glu Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asn Gly Asp Lys Gly Leu Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Ala Ser Lys Thr Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Glu Arg Met Gly Met Glu Leu Tyr Val Arg Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Thr Asp Ser Asp Ala Leu Ala Pro Ser Gly Val 
        355                 360                 365             


Met Val Ser Met Lys Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Val Val Gln 
385                 390                 395                 400 


Val Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Ile Val Thr Gly Val Ala 
            420                 425                 430         


Met Ala Leu 
        435 


<210> 120
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 120
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Pro Thr Glu Lys Ser Ala 
1               5                   10                  15      


Pro Thr Met Ser Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val 
            20                  25                  30          


Asn Arg Ser Ala Thr Lys Gly Met Thr Leu Leu Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Gln Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Thr Arg Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys 
                85                  90                  95      


Lys His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Ser Asn Ala Leu Ile Lys Ile Lys Tyr Gly 
                165                 170                 175     


Glu Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg 
            180                 185                 190         


Thr Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met 
        195                 200                 205             


Ile Thr Asp Gly Ser Ala Ser Gly Ile Ser Lys Cys Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val 
225                 230                 235                 240 


Asp His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Glu Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Lys Thr Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Glu Arg Met Gly Met Glu Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Thr Asp Ser Asp Ala Leu Ala Pro Ser Gly Val 
        355                 360                 365             


Met Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Asn Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp 
            420                 425                 430         


Met Ala Leu 
        435 


<210> 121
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 121
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Pro Thr Lys Val Ile Ala 
1               5                   10                  15      


Pro Thr Val Ser Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val 
            20                  25                  30          


Asn His Ser Ala Thr Lys Glu Met Thr Phe Leu Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Gln Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Ala Lys Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys 
                85                  90                  95      


Lys His Phe Ala Leu Thr His Tyr Ala Ala Lys Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Asn Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Ser Asn Ala Leu Ile Lys Ile Lys Tyr Gly 
                165                 170                 175     


Glu Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg 
            180                 185                 190         


Thr Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met 
        195                 200                 205             


Ile Thr Asp Gly Ser Ala Ser Gly Ile Ser Arg Cys Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val 
225                 230                 235                 240 


Glu His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Glu Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asn Gly Asp Lys Gly Asn Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Ala Ser Arg Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Lys Arg Met Gly Met Glu Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Thr Asp Ser Asp Ala Leu Thr Pro Ser Gly Val 
        355                 360                 365             


Met Ile Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Lys Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp 
            420                 425                 430         


Met Ala Leu 
        435 


<210> 122
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 122
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Ser Thr Glu Ile Thr Ala 
1               5                   10                  15      


Pro Thr Met Pro Leu Asn Cys Ala Asn Ala Ser Asn Val Gln Ala Val 
            20                  25                  30          


Asn His Ser Ala Thr Lys Gly Val Thr Leu Pro Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys 
                85                  90                  95      


Lys His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Ser Asn Ala Leu Leu Lys Ile Lys Tyr Gly 
                165                 170                 175     


Glu Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg 
            180                 185                 190         


Thr Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met 
        195                 200                 205             


Ile Thr Asp Gly Ser Ala Ser Gly Val Ser Glu Cys Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val 
225                 230                 235                 240 


Glu His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Glu Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Asn Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Ile Asp Ser Asp Ala Leu Thr Leu Ser Gly Val 
        355                 360                 365             


Met Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asn 
            420                 425                 430         


Met Ala Leu 
        435 


<210> 123
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 123
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Thr Thr Glu Ile Thr Ala 
1               5                   10                  15      


Pro Thr Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val 
            20                  25                  30          


Asn His Ser Ala Ala Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys 
                85                  90                  95      


Lys His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Ser Asn Ala Leu Leu Lys Ile Lys Tyr Gly 
                165                 170                 175     


Glu Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala His Asn Ile Leu Arg 
            180                 185                 190         


Thr Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asn Cys Tyr Leu Met 
        195                 200                 205             


Ile Thr Asp Gly Ser Ala Ser Gly Ile Ser Glu Cys Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val 
225                 230                 235                 240 


Lys His Thr Glu Glu Cys Thr Cys Gly Phe Ala Asn Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Glu Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asn Gly Asn Lys Gly Ser Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Thr Asp Ser Asp Ala Leu Val Phe Ser Gly Val 
        355                 360                 365             


Met Ile Ser Val Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asn 
            420                 425                 430         


Met Thr Leu 
        435 


<210> 124
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 124
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Arg Thr Glu Ile Thr Ala 
1               5                   10                  15      


Pro Ile Leu Arg Leu Ala Cys Ala Asn Ala Ser Asn Val Gln Ala Val 
            20                  25                  30          


Asn Arg Ser Ala Thr Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys 
                85                  90                  95      


Lys His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Ser Asn Ala Leu Leu Lys Ile Lys Tyr Gly 
                165                 170                 175     


Gly Ala Phe Thr Asp Thr Tyr His Ser Tyr Ala Lys Asn Ile Leu Ser 
            180                 185                 190         


Pro Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met 
        195                 200                 205             


Ile Thr Asp Gly Pro Ala Ser Gly Ile Ser Glu Cys Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val 
225                 230                 235                 240 


Lys His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Glu Thr Tyr Leu Asp Thr Pro Arg Pro Asn Asp Gly Ser Ile Thr Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Thr Asp Ser Glu Ala Leu Ala Leu Ser Gly Val 
        355                 360                 365             


Met Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Thr Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asn 
            420                 425                 430         


Met Thr Leu 
        435 


<210> 125
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 125
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Arg Thr Glu Ile Thr Ala 
1               5                   10                  15      


Pro Ile Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val 
            20                  25                  30          


Asn Arg Ser Ala Thr Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys 
                85                  90                  95      


Lys His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Ser Asn Ala Leu Leu Lys Ile Lys Phe Gly 
                165                 170                 175     


Glu Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Lys Asn Ile Leu Gly 
            180                 185                 190         


Thr Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Asn Leu Met 
        195                 200                 205             


Ile Thr Asp Gly Pro Ala Ser Gly Ile Ser Glu Ser Arg Phe Leu Lys 
    210                 215                 220                 


Ile Gly Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val 
225                 230                 235                 240 


Lys His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Glu Thr Tyr Leu Asp Thr Pro Arg Pro Asn Asp Gly Ser Ile Thr Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Glu Arg Met Gly Met Gly Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Ala Asp Ser Asp Ala Leu Ala Phe Ser Gly Val 
        355                 360                 365             


Met Val Ser Met Lys Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asn 
            420                 425                 430         


Met Ala Leu 
        435 


<210> 126
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 126
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Pro Thr Glu Ile Thr Ala 
1               5                   10                  15      


Pro Thr Met Pro Leu Asp Cys Ala Asn Thr Ser Asn Val Gln Ala Val 
            20                  25                  30          


Asn Arg Ser Ala Thr Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Asn Glu Cys 
                85                  90                  95      


Lys His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Gly Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Asn Asn Ala Leu Leu Lys Ile Thr Tyr Gly 
                165                 170                 175     


Glu Ala Tyr Pro Gly Thr Tyr His Ser Tyr Ala Ile Lys Asn Pro Arg 
            180                 185                 190         


Thr Gln Glu Ser Ala Pro Asn Cys Phe Gly Gly His Ser Phe Pro Ile 
        195                 200                 205             


Ile Thr His Ala Pro Pro Ser Gly Val Trp Glu Pro Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Asn Glu Ile Phe Pro Thr Gly Arg Val 
225                 230                 235                 240 


Lys Pro Pro Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Asn Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Asn Cys Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Phe His Val Glu Ser Asp Pro Ala Glu Ile Arg Ala Met Cys Thr 
        275                 280                 285             


Asp Thr Tyr Leu Asp Ser Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly 
    290                 295                 300                 


Pro Cys Asp Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Glu Ser Lys Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Glu Arg Met Gly Met Gly Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Ala Asp Ser Asp Ala Leu Ala Asn Ser Gly Val 
        355                 360                 365             


Met Val Ser Met Asn Glu Pro Gly Ser Ser Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp 
            420                 425                 430         


Met Ala Leu 
        435 


<210> 127
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 127
Leu Tyr Ser Asp Ile Leu Leu Lys Phe Ser Pro Thr Glu Ile Thr Ala 
1               5                   10                  15      


Pro Thr Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val 
            20                  25                  30          


Asn Arg Ser Ala Thr Lys Gly Val Thr Leu Phe Leu Pro Glu Pro Glu 
        35                  40                  45              


Trp Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala 
    50                  55                  60                  


Leu Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala 
65                  70                  75                  80  


Pro Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Thr Glu Cys 
                85                  90                  95      


Lys His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr 
            100                 105                 110         


Asn Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val 
        115                 120                 125             


Lys Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala 
    130                 135                 140                 


Ala Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr Tyr Ile 
145                 150                 155                 160 


Gly Val Asp Gly Pro Asp Ser Asn Ala Leu Leu Lys Ile Lys Tyr Gly 
                165                 170                 175     


Glu Ala Tyr Thr Asp Thr Tyr His Phe Tyr Ala Lys Asn Ile Leu Arg 
            180                 185                 190         


Thr Gln Glu Ser Ala Cys Ser Cys Ile Gly Gly Asp Cys Tyr Leu Met 
        195                 200                 205             


Ile Thr Asp Gly Pro Ala Ser Gly Val Ser Glu Cys Arg Phe Leu Lys 
    210                 215                 220                 


Ile Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val 
225                 230                 235                 240 


Lys His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile 
                245                 250                 255     


Glu Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val 
            260                 265                 270         


Lys Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr 
        275                 280                 285             


Glu Thr Tyr Leu Asp Thr Pro Arg Pro Asn Asp Gly Ser Ile Thr Gly 
    290                 295                 300                 


Pro Cys Glu Ser Asp Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly 
305                 310                 315                 320 


Phe Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg 
                325                 330                 335     


Thr Met Ser Lys Thr Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr 
            340                 345                 350         


Asp Gly Asp Pro Trp Thr Asp Ser Glu Ala Leu Ala Leu Ser Gly Val 
        355                 360                 365             


Met Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile 
    370                 375                 380                 


Lys Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His 
385                 390                 395                 400 


Asp Gly Gly Lys Thr Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys 
                405                 410                 415     


Leu Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp 
            420                 425                 430         


Met Ala Leu 
        435 


<210> 128
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 128
Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210> 129
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 129
Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Glu Ile Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210> 130
<211> 582
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 130
Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Thr Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Arg 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Ser Arg Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Arg Asp Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
            180                 185                 190         


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
        195                 200                 205             


Asp Asp Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro Gln 
    210                 215                 220                 


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
225                 230                 235                 240 


Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser 
                245                 250                 255     


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
            260                 265                 270         


Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
        275                 280                 285             


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
    290                 295                 300                 


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
305                 310                 315                 320 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
                325                 330                 335     


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
            340                 345                 350         


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
        355                 360                 365             


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
    370                 375                 380                 


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
385                 390                 395                 400 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
                405                 410                 415     


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
            420                 425                 430         


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
        435                 440                 445             


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
    450                 455                 460                 


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
465                 470                 475                 480 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
                485                 490                 495     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            500                 505                 510         


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        515                 520                 525             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
    530                 535                 540                 


His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val 
545                 550                 555                 560 


Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn 
                565                 570                 575     


Val Ser Cys Ser Ile Cys 
            580         


<210> 131
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 131
Met Lys Ala Ile Ile Ile Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Ala Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Asn Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Ala Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Gly Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


<210> 132
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 132
Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Lys Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Ser Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Glu Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Lys His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


<210> 133
<211> 564
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 133
Met Glu Leu Ile Val Leu Leu Ile Leu Leu Asn Pro Tyr Thr Phe Val 
1               5                   10                  15      


Leu Gly Asp Arg Ile Cys Ile Gly Tyr Gln Ala Asn Gln Asn Asn Gln 
            20                  25                  30          


Thr Val Asn Thr Leu Leu Glu Gln Asn Val Pro Val Thr Gly Ala Gln 
        35                  40                  45              


Glu Ile Leu Glu Thr Asn His Asn Gly Lys Leu Cys Ser Leu Asn Gly 
    50                  55                  60                  


Val Pro Pro Leu Asp Leu Gln Ser Cys Thr Leu Ala Gly Trp Leu Leu 
65                  70                  75                  80  


Gly Asn Pro Asn Cys Asp Ser Leu Leu Glu Ala Glu Glu Trp Ser Tyr 
                85                  90                  95      


Ile Lys Ile Asn Glu Ser Ala Pro Asp Asp Leu Cys Phe Pro Gly Asn 
            100                 105                 110         


Phe Glu Asn Leu Gln Asp Leu Leu Leu Glu Met Ser Gly Val Gln Asn 
        115                 120                 125             


Phe Thr Lys Val Lys Leu Phe Asn Pro Gln Ser Met Thr Gly Val Thr 
    130                 135                 140                 


Thr Asn Asn Val Asp Gln Thr Cys Pro Phe Glu Gly Lys Pro Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Asn Trp Ile Gln Gly Asn Ser Gly Leu Pro Phe Asn 
                165                 170                 175     


Ile Glu Ile Lys Asn Pro Thr Ser Asn Pro Leu Leu Leu Leu Trp Gly 
            180                 185                 190         


Ile His Asn Thr Lys Asp Ala Ala Gln Gln Arg Asn Leu Tyr Gly Asn 
        195                 200                 205             


Asp Tyr Ser Tyr Thr Ile Phe Asn Phe Gly Glu Lys Ser Glu Glu Phe 
    210                 215                 220                 


Arg Pro Glu Ile Gly Gln Arg Asp Glu Val Lys Ala His Gln Asp Arg 
225                 230                 235                 240 


Ile Asp Tyr Tyr Trp Gly Ser Leu Pro Ala Gln Ser Thr Leu Arg Ile 
                245                 250                 255     


Glu Ser Thr Gly Asn Leu Ile Ala Pro Glu Tyr Gly Phe Tyr Tyr Lys 
            260                 265                 270         


Arg Lys Glu Gly Lys Gly Gly Leu Met Lys Ser Lys Leu Pro Ile Ser 
        275                 280                 285             


Asp Cys Ser Thr Lys Cys Gln Thr Pro Leu Gly Ala Leu Asn Ser Thr 
    290                 295                 300                 


Leu Pro Phe Gln Asn Val His Gln Gln Thr Ile Gly Asn Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ala Thr Ser Leu Met Leu Ala Thr Gly Leu Arg Asn Asn 
                325                 330                 335     


Pro Gln Met Glu Gly Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Ile Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Glu Asn Gln Glu Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ala Thr Gln 
    370                 375                 380                 


Lys Ala Val Asp Ala Ile Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Ser Gln Phe Glu Ser Asn Ile Lys Glu Phe Asn Arg Leu Glu 
                405                 410                 415     


Leu Arg Ile Gln His Leu Ser Asp Arg Val Asp Asp Ala Leu Leu Asp 
            420                 425                 430         


Ile Trp Ser Tyr Asn Thr Glu Leu Leu Val Leu Leu Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ala Asn Val Lys Asn Leu Phe Glu Lys Val 
    450                 455                 460                 


Lys Ala Gln Leu Lys Asp Asn Ala Ile Asp Glu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Leu Leu Leu His Lys Cys Asn Asn Ser Cys Met Asp Asp Ile Lys Asn 
                485                 490                 495     


Gly Thr Tyr Lys Tyr Met Asp Tyr Arg Glu Glu Ser His Ile Glu Lys 
            500                 505                 510         


Gln Lys Ile Asp Gly Val Lys Leu Thr Asp Tyr Ser Arg Tyr Tyr Ile 
        515                 520                 525             


Met Thr Leu Tyr Ser Thr Ile Ala Ser Ser Val Val Leu Gly Ser Leu 
    530                 535                 540                 


Ile Ile Ala Ala Phe Leu Trp Gly Cys Gln Lys Gly Ser Ile Gln Cys 
545                 550                 555                 560 


Lys Ile Cys Ile 
                


<210> 134
<211> 561
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 134
Met Ile Thr Ile Leu Ile Leu Val Leu Pro Ile Val Val Gly Asp Gln 
1               5                   10                  15      


Ile Cys Ile Gly Tyr His Ser Asn Asn Ser Thr Gln Thr Val Asn Thr 
            20                  25                  30          


Leu Leu Glu Ser Asn Val Pro Val Thr Ser Ser His Ser Ile Leu Glu 
        35                  40                  45              


Lys Glu His Asn Gly Leu Leu Cys Lys Leu Lys Gly Lys Ala Pro Leu 
    50                  55                  60                  


Asp Leu Ile Asp Cys Ser Leu Pro Ala Trp Leu Met Gly Asn Pro Lys 
65                  70                  75                  80  


Cys Asp Glu Leu Leu Thr Ala Ser Glu Trp Ala Tyr Ile Lys Glu Asp 
                85                  90                  95      


Pro Glu Pro Glu Asn Gly Ile Cys Phe Pro Gly Asp Phe Asp Ser Leu 
            100                 105                 110         


Glu Asp Leu Ile Leu Leu Val Ser Asn Thr Asp His Phe Arg Lys Glu 
        115                 120                 125             


Lys Ile Ile Asp Met Thr Arg Phe Ser Asp Val Thr Thr Asn Asn Val 
    130                 135                 140                 


Asp Ser Ala Cys Pro Tyr Asp Thr Asn Gly Ala Ser Phe Tyr Arg Asn 
145                 150                 155                 160 


Leu Asn Trp Val Gln Gln Asn Lys Gly Lys Gln Leu Ile Phe His Tyr 
                165                 170                 175     


Gln Asn Ser Glu Asn Asn Pro Leu Leu Ile Ile Trp Gly Val His Gln 
            180                 185                 190         


Thr Ser Asn Ala Ala Glu Gln Asn Thr Tyr Tyr Gly Ser Gln Thr Gly 
        195                 200                 205             


Ser Thr Thr Ile Thr Ile Gly Glu Glu Thr Asn Thr Tyr Pro Leu Val 
    210                 215                 220                 


Ile Ser Glu Ser Ser Ile Leu Asn Gly His Ser Asp Arg Ile Asn Tyr 
225                 230                 235                 240 


Phe Trp Gly Val Val Asn Pro Asn Gln Asn Phe Ser Ile Val Ser Thr 
                245                 250                 255     


Gly Asn Phe Ile Trp Pro Glu Tyr Gly Tyr Phe Phe Gln Lys Thr Thr 
            260                 265                 270         


Asn Ile Ser Gly Ile Ile Lys Ser Ser Glu Lys Ile Ser Asp Cys Asp 
        275                 280                 285             


Thr Ile Cys Gln Thr Lys Ile Gly Ala Ile Asn Ser Thr Leu Pro Phe 
    290                 295                 300                 


Gln Asn Ile His Gln Asn Ala Ile Gly Asp Cys Pro Lys Tyr Val Lys 
305                 310                 315                 320 


Ala Gln Glu Leu Val Leu Ala Thr Gly Leu Arg Asn Asn Pro Ile Lys 
                325                 330                 335     


Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly 
            340                 345                 350         


Trp Gln Gly Leu Ile Asp Gly Trp Tyr Gly Tyr His His Gln Asn Ser 
        355                 360                 365             


Glu Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ala Thr Gln Lys Ala Val 
    370                 375                 380                 


Asp Ala Ile Thr Thr Lys Val Asn Asn Ile Ile Asp Lys Met Asn Thr 
385                 390                 395                 400 


Gln Phe Glu Ser Thr Ala Lys Glu Phe Asn Lys Ile Glu Met Arg Ile 
                405                 410                 415     


Lys His Leu Ser Asp Arg Val Asp Asp Gly Phe Leu Asp Val Trp Ser 
            420                 425                 430         


Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp 
        435                 440                 445             


Phe His Asp Ala Asn Val Asn Asn Leu Tyr Gln Lys Val Lys Val Gln 
    450                 455                 460                 


Leu Lys Asp Asn Ala Ile Asp Met Gly Asn Gly Cys Phe Lys Ile Leu 
465                 470                 475                 480 


His Lys Cys Asn Asn Thr Cys Met Asp Asp Ile Lys Asn Gly Thr Tyr 
                485                 490                 495     


Asn Tyr Tyr Glu Tyr Arg Lys Glu Ser His Leu Glu Lys Gln Lys Ile 
            500                 505                 510         


Asp Gly Val Lys Leu Ser Glu Asn Ser Ser Tyr Lys Ile Met Ile Ile 
        515                 520                 525             


Tyr Ser Thr Val Ala Ser Ser Val Val Leu Gly Leu Ile Ile Leu Ala 
    530                 535                 540                 


Ala Ile Glu Trp Gly Cys Phe Lys Gly Asn Leu Gln Cys Arg Ile Cys 
545                 550                 555                 560 


Ile 
    


<210> 135
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 135
Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Arg 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210> 136
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 136
Met Lys Ala Lys Leu Leu Val Leu Leu Cys Ala Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Lys Cys Glu Ser Leu Phe Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Lys Gly Val Thr Thr Ser Cys Ser His Asn Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Leu Tyr Pro 
                165                 170                 175     


Asn Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Arg Asp Gln Arg Ala Ile 
        195                 200                 205             


Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Gly Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Gly Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210> 137
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 137
Met Lys Ala Ile Leu Leu Val Leu Leu Cys Thr Phe Ala Ala Thr Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Lys Leu Gly Gly Ile 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Leu Thr Val Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Glu 
    130                 135                 140                 


Thr Asn Arg Gly Val Thr Ala Ala Cys Pro Tyr Ala Gly Ala Asn Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Ile Trp Leu Val Glu Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Pro Thr Ser Thr Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Lys Tyr Asn 
    210                 215                 220                 


Arg Lys Phe Lys Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Ile Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Asn Arg Gly Ser Gly Ser Gly Ile Ile Ile Ser Asp Ala Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Lys Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Arg Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210> 138
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 138
Met Lys Ala Thr Ile Leu Val Val Leu Cys Ile Phe Thr Ala Ser Asn 
1               5                   10                  15      


Glu Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Leu Leu Leu Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Lys Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Glu 
    130                 135                 140                 


Thr Thr Lys Gly Val Thr Ala Ala Cys Ser Tyr Ala Gly Ala Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Ser Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Pro Thr Gly Thr Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Ser Val Gly Ser Ser Lys Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Asn Arg Gly Ser Gly Ser Gly Ile Ile Thr Ser Asp Ala Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Lys Cys Gln Thr Pro His Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Arg Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ser Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Arg Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Ser Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val 
        515                 520 


<210> 139
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 139
Met Lys Ala Asn Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys 
                165                 170                 175     


Leu Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Leu Tyr 
        195                 200                 205             


Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly Ile Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210> 140
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 140
Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Thr Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Asn Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Ser Asn Ile Arg Asp Gln Arg Ala Ile Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Gly Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asn Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Met Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210> 141
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 141
Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Arg Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Lys Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Thr Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe 
145                 150                 155                 160 


Tyr Lys Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Lys Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Ile 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210> 142
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 142
Met Lys Ala Lys Leu Leu Val Leu Leu Tyr Ala Phe Val Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Ile Phe Glu Lys Asn Val Ala Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ile Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Ser Leu Leu Pro Ala Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ala Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Leu 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Phe Asn Gly Val Thr Ala Ser Cys Ser His Arg Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Asp Ser Tyr Pro Lys 
                165                 170                 175     


Leu Thr Asn Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Ser Ser Ser Asp Glu Gln Gln Ser Leu Tyr 
        195                 200                 205             


Ser Asn Gly Asn Ala Tyr Val Ser Val Ala Ser Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Lys Asp Gln His 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Glu Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ser Ile Asn Ser 
    290                 295                 300                 


Asn Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Tyr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Ile Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gly 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Leu Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210> 143
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 143
Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Lys Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Lys Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Lys Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Ile 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210> 144
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 144
Met Glu Ala Lys Leu Phe Val Leu Phe Cys Val Phe Asn Ala Leu Lys 
1               5                   10                  15      


Ala Asp Thr Ile Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Ser His Asn Gly Lys Leu Cys Ser Leu Asn Gly Lys 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Asn Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Leu Leu Leu Thr Ala Asn Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ile Glu Thr Ser Asn Ser Lys Asn Gly Lys Cys Tyr Pro Gly Glu Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Thr Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Ala Thr Ser Trp Pro Asn His Glu 
    130                 135                 140                 


Thr Thr Lys Gly Thr Thr Thr Ala Cys Ser His Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Ile Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Thr Asn Asn Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Ile Trp Gly Val His His Pro Pro Thr Asn Ser Asp Gln Gln Thr Leu 
        195                 200                 205             


Tyr Gln Asn Ala Tyr Thr Tyr Val Ser Val Glu Ser Ser Lys Tyr Tyr 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Asp Gln Gly Asp Thr 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Asn Lys Gly Ser Asn Ser Gly Ile Met Met Ser Asp Ala His 
        275                 280                 285             


Val His Asn Cys Thr Thr Lys Cys Gln Thr Pro His Gly Ala Leu Lys 
    290                 295                 300                 


Ser Asn Leu Pro Phe Gln Asn Val His Pro Ile Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Gln Leu Arg Met Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Ile Ala Ile Asp Gly Ile Ser Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Ile Gln Phe Thr Ser Val Gly Lys Glu Phe Asn Asn 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Ile Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Phe Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Val Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asn Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val His 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210> 145
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 145
Met Lys Ala Lys Leu Leu Val Leu Leu Cys Ala Leu Ser Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Phe Ser Lys Lys Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Arg Ser Trp Pro Lys His Asn 
    130                 135                 140                 


Val Thr Arg Gly Val Thr Ala Ser Cys Ser His Lys Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Ser Tyr Pro 
                165                 170                 175     


Asn Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Glu Asp Gln Lys Thr Ile 
        195                 200                 205             


Tyr Arg Lys Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp His Ala Phe 
            260                 265                 270         


Ala Leu Asn Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met Asp Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210> 146
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 146
Met Lys Ala Lys Leu Leu Val Leu Leu Cys Ala Phe Thr Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Phe Ser Lys Lys Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Lys Gly Val Thr Ala Ser Cys Ser His Lys Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Ser Tyr Pro 
                165                 170                 175     


Thr Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Gly Asp Gln Arg Ala Ile 
        195                 200                 205             


Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210> 147
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 147
Met Glu Ala Arg Leu Phe Val Leu Phe Cys Thr Phe Thr Val Leu Lys 
1               5                   10                  15      


Ala Asp Ile Ile Cys Val Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Ser Ser His Asn Gly Lys Leu Cys Ser Leu Asn Gly Ile 
    50                  55                  60                  


Pro Pro Leu Gln Leu Gly Lys Cys Asn Val Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Gln Leu Leu Thr Ala Asn Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ile Glu Thr Ser Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Glu Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Lys Phe Glu Ile Phe Pro Lys Ala Ser Ser Trp Pro Asn His Glu 
    130                 135                 140                 


Thr Thr Lys Gly Val Thr Ala Ala Cys Pro Tyr Leu Gly Asn Ser Asn 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Ile Thr Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Glu Leu Ser Lys Ser Tyr Thr Asn Asn Lys Gly Lys Glu Val Leu Ile 
            180                 185                 190         


Leu Trp Gly Val His His Pro Pro Ser Thr Asn Glu Gln Gln Asn Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asn Ala Tyr Val Ser Val Gly Ser Ser Lys Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Asp Gln Gly Asp Thr 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Asn Lys Asn Ser Asp Ser Gly Ile Met Met Ser Asp Ala Pro 
        275                 280                 285             


Val His Asn Cys Asp Thr Lys Cys Gln Thr Pro His Gly Ala Leu Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Ile Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Ile Lys Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Arg Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Val Cys Ile 
                565     


<210> 148
<211> 562
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 148
Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Asp 
1               5                   10                  15      


Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Lys Val Asp 
            20                  25                  30          


Thr Ile Leu Glu Arg Asn Val Thr Val Thr His Ala Lys Asp Ile Leu 
        35                  40                  45              


Glu Lys Thr His Asn Gly Lys Leu Cys Lys Leu Asn Gly Ile Pro Pro 
    50                  55                  60                  


Leu Glu Leu Gly Asp Cys Ser Ile Ala Gly Trp Leu Leu Gly Asn Pro 
65                  70                  75                  80  


Glu Cys Asp Arg Leu Leu Ser Val Pro Glu Trp Ser Tyr Ile Met Glu 
                85                  90                  95      


Lys Glu Asn Pro Arg Asp Gly Leu Cys Tyr Pro Gly Ser Phe Asn Asp 
            100                 105                 110         


Tyr Glu Glu Leu Lys His Leu Leu Ser Ser Val Lys His Phe Glu Lys 
        115                 120                 125             


Val Lys Ile Leu Pro Lys Asp Arg Trp Thr Gln His Thr Thr Thr Gly 
    130                 135                 140                 


Gly Ser Arg Ala Cys Ala Val Ser Gly Asn Pro Ser Phe Phe Arg Asn 
145                 150                 155                 160 


Met Val Trp Leu Thr Lys Lys Gly Ser Asn Tyr Pro Val Ala Gln Gly 
                165                 170                 175     


Ser Tyr Asn Asn Thr Ser Gly Glu Gln Met Leu Ile Ile Trp Gly Val 
            180                 185                 190         


His His Pro Asn Asp Glu Thr Glu Gln Arg Thr Leu Tyr Gln Asn Val 
        195                 200                 205             


Gly Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Lys Arg Ser Thr 
    210                 215                 220                 


Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Gly Gly Arg Met 
225                 230                 235                 240 


Glu Phe Ser Trp Thr Leu Leu Asp Met Trp Asp Thr Ile Asn Phe Glu 
                245                 250                 255     


Ser Thr Gly Asn Leu Ile Ala Pro Glu Tyr Gly Phe Lys Ile Ser Lys 
            260                 265                 270         


Arg Gly Ser Ser Gly Ile Met Lys Thr Glu Gly Thr Leu Glu Asn Cys 
        275                 280                 285             


Glu Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Thr Thr Leu Pro 
    290                 295                 300                 


Phe His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val 
305                 310                 315                 320 


Lys Ser Glu Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Val Pro Gln 
                325                 330                 335     


Ile Glu Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
            340                 345                 350         


Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn 
        355                 360                 365             


Asp Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala 
    370                 375                 380                 


Phe Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn 
385                 390                 395                 400 


Thr Gln Phe Glu Ala Val Gly Lys Glu Phe Ser Asn Leu Glu Arg Arg 
                405                 410                 415     


Leu Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp 
            420                 425                 430         


Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu 
        435                 440                 445             


Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Met 
    450                 455                 460                 


Gln Leu Arg Asp Asn Val Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe 
465                 470                 475                 480 


Tyr His Lys Cys Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr 
                485                 490                 495     


Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu 
            500                 505                 510         


Ile Lys Gly Val Lys Leu Ser Ser Met Gly Val Tyr Gln Ile Leu Ala 
        515                 520                 525             


Ile Tyr Ala Thr Val Ala Gly Ser Leu Ser Leu Ala Ile Met Met Ala 
    530                 535                 540                 


Gly Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
545                 550                 555                 560 


Cys Ile 
        


<210> 149
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 149
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Ala 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Ser Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asp Val Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 150
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 150
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Ala 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Ser Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asp Val Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 151
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 151
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val Leu His Pro Gly Thr Asp Ser Asp Gln Ile 
        195                 200                 205             


Arg Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asp Val Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Ile Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln Tyr Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys 
                485             


<210> 152
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 152
Met Lys Thr Ile Ile Ala Leu Ser His Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Gln Leu Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Val Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Tyr Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 153
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 153
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Glu Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Ser Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asp Glu Ser Phe Asn Trp Ala 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Gly Ser Asn 
145                 150                 155                 160 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Ser Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Lys Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 154
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 154
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ser Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asn Asn Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Thr Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 155
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 155
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Ala Gln Asn Gly Thr Ser Tyr Ala Cys Lys Arg Ser Ser Ile 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu His Gln Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Asp Gln Thr 
        195                 200                 205             


Ser Ile Tyr Ala Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Ile Ser Ser Arg Ile Ser Ile His Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 156
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 156
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Thr Asn Glu Gly Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Ala Gln Asp Gly Thr Ser Tyr Ala Cys Lys Arg Gly Ser Val 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu His Lys Leu Glu Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Val Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Ile Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Asn Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 157
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 157
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Ser Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 158
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 158
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Lys 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ser Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 159
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 159
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Thr 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Asn Asp Gln Ile 
        195                 200                 205             


Phe Pro Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 160
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 160
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Ala Leu Gly 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asp Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Lys Ile Cys Asn Asn Pro His Arg Ile Leu Asp Gly Ile Asp Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Val Phe Gln 
                85                  90                  95      


Asn Glu Thr Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Phe Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Thr Glu Gly Phe Thr Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Gly Ser Asn Ala Cys Lys Arg Gly Pro Gly 
145                 150                 155                 160 


Ser Gly Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Ser Thr 
                165                 170                 175     


Tyr Pro Val Leu Asn Val Thr Met Pro Asn Asn Asp Asn Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asn Gln Glu Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Arg Arg 
    210                 215                 220                 


Ser Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Val Leu Val Ile Asn Ser Asn Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Met Arg Thr Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Asp Thr Cys Ile Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Leu Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Val 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Arg Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 161
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 161
Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Ala Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Ile 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu His Gln Leu Glu Asn Arg 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Val Gln Thr 
        195                 200                 205             


Ser Val Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Val Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Met Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210> 162
<211> 567
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 162
Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Arg Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asn Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ile Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Asn Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe Arg 
145                 150                 155                 160 


Asn Val Val Trp Leu Thr Gln Lys Asp Asn Ala Tyr Pro Thr Ile Lys 
                165                 170                 175     


Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly 
            180                 185                 190         


Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln Asn 
        195                 200                 205             


Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu 
    210                 215                 220                 


Ile Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg 
225                 230                 235                 240 


Met Glu Phe Phe Trp Thr Ile Leu Lys Ser Asn Asp Ala Ile Asn Phe 
                245                 250                 255     


Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Asn Ala Tyr Lys Ile Val 
            260                 265                 270         


Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn 
        275                 280                 285             


Cys Asn Thr Lys Cys Gln Thr Pro Ile Gly Ala Ile Asn Ser Ser Met 
    290                 295                 300                 


Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr 
305                 310                 315                 320 


Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser Pro 
                325                 330                 335     


Gln Gly Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu 
    370                 375                 380                 


Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile 
385                 390                 395                 400 


Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn 
                405                 410                 415     


Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly 
            420                 425                 430         


Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu 
        435                 440                 445             


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
    450                 455                 460                 


Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Glu Phe Tyr His Arg Cys Asp Asn Glu Cys Met Glu Ser 
                485                 490                 495     


Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg 
            500                 505                 510         


Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Thr 
        515                 520                 525             


Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu 
    530                 535                 540                 


Ala Ile Met Val Ala Gly Leu Phe Leu Trp Met Cys Ser Asn Gly Ser 
545                 550                 555                 560 


Leu Gln Cys Arg Ile Cys Ile 
                565         


<210> 163
<211> 569
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 163
Met Glu Lys Ile Val Leu Leu Leu Ala Met Ile Gly Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asn Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Lys Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Leu Asn Val Ser Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Ser Pro Ala Asn Gly Leu Cys Tyr Pro Gly Asp Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Leu Lys 
        115                 120                 125             


Lys Ile Lys Ile Ile Pro Lys Ser Tyr Trp Ser Asn His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ala Ala Cys Ser Tyr Leu Gly Glu Pro Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Pro Ile 
                165                 170                 175     


Lys Val Asn Tyr Thr Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Glu Lys Glu Gln Ile Arg Ile Tyr Gln 
        195                 200                 205             


Asn Pro Asn Thr Ser Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ser Ile Asn 
                245                 250                 255     


Phe Asp Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Ala Lys Lys Gly Asp Ser Val Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ala 
                325                 330                 335     


Pro Gln Arg Glu Gly Gly Arg Arg Arg Lys Arg Gly Leu Phe Gly Ala 
            340                 345                 350         


Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp 
        355                 360                 365             


Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp 
    370                 375                 380                 


Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Ile Thr Asn Lys Val Asn 
385                 390                 395                 400 


Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ile Val Gly Arg Glu 
                405                 410                 415     


Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu 
            420                 425                 430         


Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
        435                 440                 445             


Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 
    450                 455                 460                 


Leu Tyr Glu Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu 
465                 470                 475                 480 


Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met 
                485                 490                 495     


Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu 
            500                 505                 510         


Ala Arg Leu Ser Arg Glu Glu Ile Ser Gly Val Lys Met Glu Ser Met 
        515                 520                 525             


Val Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu 
    530                 535                 540                 


Ala Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn 
545                 550                 555                 560 


Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 


<210> 164
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 164
Met Glu Lys Ile Val Leu Leu Phe Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser 
    130                 135                 140                 


Leu Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
    370                 375                 380                 


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
385                 390                 395                 400 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
                405                 410                 415     


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
            420                 425                 430         


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
            500                 505                 510         


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly 
        515                 520                 525             


Ile Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
    530                 535                 540                 


Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
545                 550                 555                 560 


Ser Leu Gln Cys Arg 
                565 


<210> 165
<211> 568
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 165
Met Glu Lys Ile Val Leu Leu Phe Ala Ile Ile Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp His Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asn Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Lys Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asp Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Arg Ile Ile Pro Lys Asp Ser Trp Pro Asp His Glu Ala Ser 
    130                 135                 140                 


Leu Gly Val Ser Ala Ala Cys Ser Tyr Gln Gly Asn Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Leu Lys Lys Asp Asn Ala Tyr Pro Ile Ile 
                165                 170                 175     


Lys Lys Ser Tyr Asn Asn Thr Asn Lys Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Glu Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Val Ser Ile Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Ile Asp Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Arg Ser Glu Val Glu Tyr Gly 
        275                 280                 285             


Asn Cys Ser Thr Arg Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Ile Glu Arg Arg Arg Arg Lys Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
    370                 375                 380                 


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
385                 390                 395                 400 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
                405                 410                 415     


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
            420                 425                 430         


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
            500                 505                 510         


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly 
        515                 520                 525             


Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Val 
    530                 535                 540                 


Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
545                 550                 555                 560 


Ser Leu Gln Cys Arg Ile Cys Ile 
                565             


<210> 166
<211> 568
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 166
Met Glu Lys Ile Val Leu Leu Leu Ala Thr Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Arg Thr His Asn Gly Lys Leu Cys Asp Leu Asn Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Ser Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Ser His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asn His Asp Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Leu Gly Lys Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Ile Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ala 
                325                 330                 335     


Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln 
    370                 375                 380                 


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
385                 390                 395                 400 


Ile Ile Asn Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
                405                 410                 415     


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
            420                 425                 430         


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
            500                 505                 510         


Arg Leu Asn Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Met Gly 
        515                 520                 525             


Thr Tyr Gln Ile Leu Ser Leu Tyr Ser Thr Val Ala Ser Ser Leu Ala 
    530                 535                 540                 


Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
545                 550                 555                 560 


Ser Leu Gln Cys Arg Ile Cys Ile 
                565             


<210> 167
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 167
Met Ile Ala Ile Ile Val Ile Ala Ile Leu Ala Ala Ala Gly Lys Ser 
1               5                   10                  15      


Asp Lys Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Thr Gln Val 
            20                  25                  30          


Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Glu Leu 
        35                  40                  45              


Leu Glu Asn Gln Lys Glu Glu Arg Phe Cys Lys Ile Leu Asn Lys Ala 
    50                  55                  60                  


Pro Leu Asp Leu Arg Gly Cys Thr Ile Glu Gly Trp Ile Leu Gly Asn 
65                  70                  75                  80  


Pro Gln Cys Asp Leu Leu Leu Gly Asp Gln Ser Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Arg Pro Asn Ala Gln Tyr Gly Ile Cys Tyr Pro Gly Val Leu Asn 
            100                 105                 110         


Glu Val Glu Glu Leu Lys Ala Leu Ile Gly Ala Gly Glu Arg Val Glu 
        115                 120                 125             


Arg Phe Glu Met Phe Pro Lys Ser Thr Trp Ala Gly Val Asp Thr Ser 
    130                 135                 140                 


Ser Gly Val Thr Arg Ala Cys Pro Tyr Asn Ser Gly Ser Ser Phe Tyr 
145                 150                 155                 160 


Arg Asn Leu Leu Trp Ile Ile Lys Thr Lys Ser Ala Ala Tyr Pro Val 
                165                 170                 175     


Ile Arg Gly Thr Tyr Asn Asn Thr Gly Lys Gln Pro Ile Leu Tyr Phe 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asp Ile Asn Glu Gln Asn Thr Leu Tyr 
        195                 200                 205             


Gly Ser Gly Asp Arg Tyr Val Arg Met Gly Thr Glu Asn Met Asn Phe 
    210                 215                 220                 


Ala Lys Ser Pro Glu Ile Ala Ala Arg Pro Ala Val Asn Gly Gln Arg 
225                 230                 235                 240 


Gly Arg Ile Asp Tyr Tyr Trp Ser Val Leu Lys Pro Gly Glu Thr Leu 
                245                 250                 255     


Asn Val Glu Ser Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Tyr Lys 
            260                 265                 270         


Phe Val Ser Thr Asn Asn Lys Gly Ala Ile Phe Lys Ser Asn Leu Pro 
        275                 280                 285             


Ile Glu Asn Cys Asp Ala Thr Cys Gln Thr Ile Ala Gly Ala Leu Arg 
    290                 295                 300                 


Thr Asn Lys Thr Phe Gln Asn Val Ser Pro Leu Trp Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Glu Ser Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Gln Ile Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Glu Asn Ser Gln Gly Ser Gly Tyr Ala Ala Asp Arg Glu Ser 
    370                 375                 380                 


Thr Gln Lys Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile 
385                 390                 395                 400 


Asp Lys Met Asn Thr Gln Phe Glu Ala Val Asp His Glu Phe Ser Asn 
                405                 410                 415     


Leu Glu Arg Arg Ile Asp Asn Leu Asn Lys Arg Met Glu Asp Gly Phe 
            420                 425                 430         


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Leu His Asp Ala Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Arg Asp Asn Ala Asn Asp Leu Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Trp His Lys Cys Asp Asn Glu Cys Ile Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Gln Asp Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Gln Glu Ile Glu Ser Val Lys Leu Glu Asn Leu Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ser Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Gly Leu Ile Ile Ala Met Gly Leu Trp Met Cys Ser Asn Gly Ser Met 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210> 168
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 168
Met Ile Ala Phe Ile Val Ile Ala Ile Leu Val Thr Thr Gly Lys Ser 
1               5                   10                  15      


Asp Lys Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Thr Lys Val 
            20                  25                  30          


Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Glu Leu 
        35                  40                  45              


Leu Glu Asn Gln Lys Glu Glu Arg Phe Cys Lys Ile Ser Asn Lys Ala 
    50                  55                  60                  


Pro Leu Asp Leu Arg Asp Cys Thr Leu Glu Gly Trp Ile Leu Gly Asn 
65                  70                  75                  80  


Pro Arg Cys Gly Ile Leu Leu Ala Asp Gln Ser Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Arg Pro Asn Ala Arg Asn Gly Ile Cys Tyr Pro Gly Thr Leu Asn 
            100                 105                 110         


Glu Val Glu Glu Leu Lys Ala Leu Ile Gly Ser Gly Glu Arg Val Glu 
        115                 120                 125             


Arg Phe Glu Met Phe Pro Lys Ser Thr Trp Ala Gly Val Asp Thr Asn 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Leu Gly Asn Gly Pro Ser Phe Tyr 
145                 150                 155                 160 


Arg Asn Leu Leu Trp Ile Ile Lys His Thr Thr Ser Gly Tyr Pro Val 
                165                 170                 175     


Ile Lys Gly Thr Tyr Thr Asn Thr Gly Asp Lys Ser Val Leu Tyr Phe 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asp Thr Thr Glu Gln Asn Val Leu Tyr 
        195                 200                 205             


Gly Ser Gly Asn Arg Tyr Val Arg Met Gly Thr Glu Ser Met Asn Phe 
    210                 215                 220                 


Ala Arg Ser Pro Glu Val Ala Ala Arg Pro Ala Val Asn Gly Gln Arg 
225                 230                 235                 240 


Gly Arg Ile Asp Tyr Phe Trp Ser Ile Leu Lys Pro Gly Glu Thr Leu 
                245                 250                 255     


Asn Val Glu Ser Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Tyr Arg 
            260                 265                 270         


Phe Val Asn Lys Asp Ser Lys Gly Ala Ile Phe Arg Ser Asn Leu Pro 
        275                 280                 285             


Ile Glu Asn Cys Asp Ala Thr Cys Gln Thr Thr Glu Gly Val Ile Arg 
    290                 295                 300                 


Thr Asn Lys Thr Phe Gln Asn Val Ser Pro Leu Trp Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Lys Ser Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Gln Ile Glu Thr Arg Gly Leu Phe Gly Asp Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Glu Asn Ser Gln Gly Ser Gly Tyr Ala Ala Asp Arg Glu Ser 
    370                 375                 380                 


Thr Gln Lys Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile 
385                 390                 395                 400 


Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly His Glu Phe Ser Asn 
                405                 410                 415     


Leu Glu Arg Arg Ile Asp Asn Leu Asn Lys Arg Met Glu Asp Gly Phe 
            420                 425                 430         


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Leu His Asp Ala Asn Val Lys Asn Leu His Glu 
    450                 455                 460                 


Arg Val Lys Ser Gln Leu Arg Asp Asn Ala Asn Asp Leu Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Trp His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asn Tyr Pro Lys Tyr Gln Ala Glu Ser Arg Leu 
            500                 505                 510         


Asn Lys Gln Lys Ile Glu Ser Val Lys Leu Glu Glu Phe Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ser Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Gly Leu Ile Met Ala Met Gly Leu Trp Met Cys Ser Asn Gly Ser Met 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210> 169
<211> 570
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 169
Met Asn Thr Gln Ile Leu Ile Leu Ala Ile Ser Ala Phe Leu Cys Val 
1               5                   10                  15      


Arg Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr 
            20                  25                  30          


Lys Val Asp Thr Leu Thr Glu Lys Gly Ile Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Thr Val Glu Gln Lys Asn Ile Pro Lys Ile Cys Ser Lys Gly Lys 
    50                  55                  60                  


Gln Thr Ile Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Thr Ile Gly 
65                  70                  75                  80  


Pro Pro Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asn Leu Ile Ile 
                85                  90                  95      


Glu Arg Arg Glu Gly Asp Asp Ile Cys Tyr Pro Gly Lys Phe Asp Asn 
            100                 105                 110         


Glu Glu Thr Leu Arg Gln Ile Leu Arg Lys Ser Gly Gly Ile Lys Lys 
        115                 120                 125             


Glu Asn Met Gly Phe Thr Tyr Thr Gly Val Arg Thr Asn Gly Glu Thr 
    130                 135                 140                 


Ser Ala Cys Arg Arg Ser Arg Ser Ser Phe Tyr Ala Glu Met Lys Trp 
145                 150                 155                 160 


Leu Leu Ser Asn Thr Asp Asn Gly Val Phe Pro Gln Met Thr Lys Ser 
                165                 170                 175     


Tyr Lys Asn Thr Lys Arg Glu Pro Ala Leu Ile Ile Trp Gly Ile His 
            180                 185                 190         


His Ser Gly Ser Thr Ala Glu Gln Thr Arg Leu Tyr Gly Ser Gly Asn 
        195                 200                 205             


Lys Leu Val Thr Val Trp Ser Ser Lys Tyr Gln Gln Ser Phe Ala Pro 
    210                 215                 220                 


Ser Pro Gly Pro Lys Pro Gln Ile Asn Gly Gln Ser Gly Arg Ile Asp 
225                 230                 235                 240 


Phe Tyr Trp Leu Met Leu Asp Pro Asn Asp Thr Val Thr Phe Ser Phe 
                245                 250                 255     


Asn Gly Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys 
            260                 265                 270         


Ser Leu Gly Ile Gln Ser Asp Ala Gln Leu Asp Asn Asn Cys Glu Gly 
        275                 280                 285             


Glu Cys Tyr His Ile Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln 
    290                 295                 300                 


Asn Ile Asn Ser Arg Ala Ile Gly Lys Cys Pro Arg Tyr Val Lys Gln 
305                 310                 315                 320 


Lys Ser Leu Met Leu Ala Thr Gly Met Lys Asn Val Pro Glu Asn Ser 
                325                 330                 335     


Ile His Lys Gln Leu Thr His His Met Arg Lys Lys Arg Gly Leu Phe 
            340                 345                 350         


Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Leu Ile Asp 
        355                 360                 365             


Gly Trp Tyr Gly Tyr Arg His Gln Asn Ala Gln Gly Glu Gly Thr Ala 
    370                 375                 380                 


Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asn Gln Ile Thr Gly Lys 
385                 390                 395                 400 


Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln Phe Glu Leu Ile Asp 
                405                 410                 415     


Asn Glu Phe Asn Glu Ile Glu Lys Gln Ile Gly Asn Val Ile Asn Trp 
            420                 425                 430         


Thr Arg Asp Ser Ile Ile Glu Val Trp Ser Tyr Asn Ala Glu Phe Leu 
        435                 440                 445             


Val Ala Val Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met 
    450                 455                 460                 


Asn Lys Leu Tyr Glu Lys Val Arg Arg Gln Leu Arg Glu Asn Ala Glu 
465                 470                 475                 480 


Glu Asp Gly Asn Gly Cys Phe Glu Ile Phe His Gln Cys Asp Asn Asp 
                485                 490                 495     


Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His Lys Lys Tyr Arg 
            500                 505                 510         


Lys Glu Ala Ile Gln Asn Arg Ile Gln Ile Asp Ala Val Lys Leu Ser 
        515                 520                 525             


Ser Gly Tyr Lys Asp Ile Ile Leu Trp Phe Ser Phe Gly Ala Ser Cys 
    530                 535                 540                 


Phe Leu Phe Leu Ala Ile Ala Met Val Leu Ala Phe Ile Cys Ile Lys 
545                 550                 555                 560 


Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
                565                 570 


<210> 170
<211> 569
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 170
Ser Lys Ser Arg Gly Tyr Lys Met Asn Thr Gln Ile Leu Val Phe Ala 
1               5                   10                  15      


Leu Val Ala Ser Ile Pro Thr Asn Ala Asp Lys Ile Cys Leu Gly His 
            20                  25                  30          


His Ala Val Ser Asn Gly Thr Lys Val Asn Thr Leu Thr Glu Arg Gly 
        35                  40                  45              


Val Glu Val Val Asn Ala Thr Glu Thr Val Glu Arg Thr Asn Val Pro 
    50                  55                  60                  


Arg Ile Cys Ser Lys Gly Lys Arg Thr Val Asp Leu Gly Gln Cys Gly 
65                  70                  75                  80  


Leu Leu Gly Thr Ile Thr Gly Pro Pro Gln Cys Asp Gln Phe Leu Glu 
                85                  90                  95      


Phe Ser Ala Asp Leu Ile Ile Glu Arg Arg Glu Gly Ser Asp Val Cys 
            100                 105                 110         


Tyr Pro Gly Lys Phe Val Asn Glu Glu Ala Leu Arg Gln Ile Leu Arg 
        115                 120                 125             


Glu Ser Gly Gly Ile Asp Lys Glu Thr Met Gly Phe Thr Tyr Ser Gly 
    130                 135                 140                 


Ile Arg Thr Asn Gly Thr Thr Ser Ala Cys Arg Arg Ser Gly Ser Ser 
145                 150                 155                 160 


Phe Tyr Ala Glu Met Lys Trp Leu Leu Ser Asn Thr Asp Asn Ala Ala 
                165                 170                 175     


Phe Pro Gln Met Thr Lys Ser Tyr Lys Asn Thr Arg Lys Asp Pro Ala 
            180                 185                 190         


Leu Ile Ile Trp Gly Ile His His Ser Gly Ser Thr Thr Glu Gln Thr 
        195                 200                 205             


Lys Leu Tyr Gly Ser Gly Asn Lys Leu Ile Thr Val Gly Ser Ser Asn 
    210                 215                 220                 


Tyr Gln Gln Ser Phe Val Pro Ser Pro Gly Ala Arg Pro Gln Val Asn 
225                 230                 235                 240 


Gly Gln Ser Gly Arg Ile Asp Phe His Trp Leu Ile Leu Asn Pro Asn 
                245                 250                 255     


Asp Thr Val Thr Phe Ser Phe Asn Gly Ala Phe Ile Ala Pro Asp Arg 
            260                 265                 270         


Ala Ser Phe Leu Arg Gly Lys Ser Met Gly Ile Gln Ser Glu Val Gln 
        275                 280                 285             


Val Asp Ala Asn Cys Glu Gly Asp Cys Tyr His Ser Gly Gly Thr Ile 
    290                 295                 300                 


Ile Ser Asn Leu Pro Phe Gln Asn Ile Asn Ser Arg Ala Val Gly Lys 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Glu Ser Leu Leu Leu Ala Thr Gly Met 
                325                 330                 335     


Lys Asn Val Pro Glu Ile Pro Lys Arg Arg Arg Arg Gly Leu Phe Gly 
            340                 345                 350         


Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Leu Ile Asp Gly 
        355                 360                 365             


Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly Glu Gly Thr Ala Ala 
    370                 375                 380                 


Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asp Gln Ile Thr Gly Lys Leu 
385                 390                 395                 400 


Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln Phe Glu Leu Ile Asp Asn 
                405                 410                 415     


Glu Phe Thr Glu Val Glu Arg Gln Ile Gly Asn Val Ile Asn Trp Thr 
            420                 425                 430         


Arg Asp Ser Met Thr Glu Val Trp Ser Tyr Asn Ala Glu Leu Leu Val 
        435                 440                 445             


Ala Met Glu Asn Gln His Thr Ile Asp Leu Ala Asp Ser Glu Met Asn 
    450                 455                 460                 


Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg Glu Asn Ala Glu Glu 
465                 470                 475                 480 


Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys Cys Asp Asp Asp Cys 
                485                 490                 495     


Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His Ser Lys Tyr Arg Glu 
            500                 505                 510         


Glu Ala Ile Gln Asn Arg Ile Gln Ile Asp Pro Val Lys Leu Ser Ser 
        515                 520                 525             


Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser Phe Gly Ala Ser Cys Phe 
    530                 535                 540                 


Ile Leu Leu Ala Ile Ala Met Gly Leu Val Phe Ile Cys Val Lys Asn 
545                 550                 555                 560 


Gly Asn Met Arg Cys Thr Ile Cys Ile 
                565                 


<210> 171
<211> 549
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 171
Thr Gln Ile Leu Val Phe Ala Leu Ile Ala Ile Ile Pro Thr Asn Ala 
1               5                   10                  15      


Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
            20                  25                  30          


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
        35                  40                  45              


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
    50                  55                  60                  


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
65                  70                  75                  80  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
                85                  90                  95      


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
            100                 105                 110         


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
        115                 120                 125             


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
    130                 135                 140                 


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp Leu Leu 
145                 150                 155                 160 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
                165                 170                 175     


Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Ser 
            180                 185                 190         


Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
        195                 200                 205             


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Ser Pro 
    210                 215                 220                 


Gly Ala Arg Pro Pro Val Asn Gly Leu Ser Gly Arg Ile Asp Phe His 
225                 230                 235                 240 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
                245                 250                 255     


Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met 
            260                 265                 270         


Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp Cys 
        275                 280                 285             


Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn Ile 
    290                 295                 300                 


Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg Ser 
305                 310                 315                 320 


Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys Gly 
                325                 330                 335     


Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
            340                 345                 350         


Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly 
        355                 360                 365             


Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asp Gln 
    370                 375                 380                 


Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln Phe 
385                 390                 395                 400 


Glu Leu Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile Gly Asn 
                405                 410                 415     


Val Ile Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser Tyr Asn 
            420                 425                 430         


Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Ala 
        435                 440                 445             


Asp Ser Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg 
    450                 455                 460                 


Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys 
465                 470                 475                 480 


Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His 
                485                 490                 495     


Ser Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp Pro 
            500                 505                 510         


Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser Phe 
        515                 520                 525             


Gly Ala Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu Val Phe 
    530                 535                 540                 


Ile Cys Val Lys Asn 
545                 


<210> 172
<211> 851
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 172
Met Arg Val Met Glu Thr Gln Arg Ser Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Leu Ile Ile Tyr Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Asn Thr Gln Glu Val Lys Asn Cys Thr Phe 
    130                 135                 140                 


Asn Met Thr Thr Glu Leu Arg Asp Lys Arg Gln Lys Val Ser Ser Leu 
145                 150                 155                 160 


Phe Tyr Lys Leu Asp Ile Val Pro Ile Glu Glu Gly Gln Gly Asn Ser 
                165                 170                 175     


Ser Asn Ser Ser Tyr Glu Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
            180                 185                 190         


Ala Ile Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile 
        195                 200                 205             


His Tyr Cys Thr Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Glu 
    210                 215                 220                 


Glu Phe Asn Gly Thr Gly Pro Cys Arg Asn Val Ser Thr Val Gln Cys 
225                 230                 235                 240 


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
                245                 250                 255     


Ser Leu Ala Lys Asn Lys Val Ile Ile Arg Ser Glu Asn Ile Thr Asn 
            260                 265                 270         


Asn Val Lys Thr Ile Ile Val Gln Leu Ala Glu Pro Val Ile Ile Asn 
        275                 280                 285             


Cys Thr Arg Pro Asn Asn Asn Thr Arg Glu Ser Val Arg Ile Gly Pro 
    290                 295                 300                 


Gly Gln Thr Phe Tyr Thr Ser Asn Ile Ile Gly Asp Ile Arg Gln Ala 
305                 310                 315                 320 


His Cys Asn Val Ser Lys Ser Ala Trp Asn Lys Thr Leu His Val Val 
                325                 330                 335     


Gly Glu Gln Leu Glu Lys Tyr Phe Val Asn Lys Thr Ile Lys Phe Asp 
            340                 345                 350         


Arg Pro Thr Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Glu Leu Phe Asn Ser Thr 
    370                 375                 380                 


Trp Asn Ser Ser Thr Gln Gly Thr Asn Asn Thr Glu Leu Asn Asp Thr 
385                 390                 395                 400 


Ile Thr Leu Pro Cys Arg Ile Lys Gln Val Ile Asn Met Trp Gln Arg 
                405                 410                 415     


Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Lys Gly Ile Ile Lys Cys 
            420                 425                 430         


Val Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Ile Asn 
        435                 440                 445             


Ser Thr Asn Gly Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
    450                 455                 460                 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Gln Ile Glu 
465                 470                 475                 480 


Pro Leu Gly Val Ala Pro Thr Lys Ala Arg Arg Arg Thr Val Gly Arg 
                485                 490                 495     


Glu Lys Arg Ala Ile Gly Leu Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Ile Glu Ala Gln Gln Gln Met Leu Arg Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Thr Gln Glu 
        595                 600                 605             


Glu Ile Trp Gly Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser 
    610                 615                 620                 


Asn Tyr Thr Glu Ile Ile Tyr Asn Leu Ile Glu Lys Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Lys Trp Ala Thr 
                645                 650                 655     


Leu Trp Ser Trp Phe Asp Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile 
            660                 665                 670         


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala 
        675                 680                 685             


Val Leu Ser Val Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
    690                 695                 700                 


Phe Gln Thr His Thr Pro Asn Pro Arg Gly Leu Asp Arg Pro Gly Gly 
705                 710                 715                 720 


Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Thr Arg Ser Ile Arg Leu 
                725                 730                 735     


Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys 
            740                 745                 750         


Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Val Trp Ile Ala Lys Arg 
        755                 760                 765             


Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly 
    770                 775                 780                 


Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Val Tyr Trp Gly Leu 
785                 790                 795                 800 


Glu Leu Lys Lys Ser Ala Ile Asn Leu Phe Asp Thr Ile Ala Ile Val 
                805                 810                 815     


Val Ala Gly Trp Thr Asp Arg Ile Ile Glu Ile Gly Gln Gly Ile Gly 
            820                 825                 830         


Arg Gly Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Asn 
        835                 840                 845             


Phe Leu Leu 
    850     


<210> 173
<211> 856
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 173
Met Arg Val Thr Gly Ile Gln Lys Asn Cys Gln Ser Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Leu Met Ile Cys Ser Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asn Ala Arg Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asp Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Phe Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asp Cys Gly Tyr Asn Val Thr Asn Leu Thr Ser Thr Ser Asn Met Lys 
    130                 135                 140                 


Glu Asp Ile Thr Asn Cys Ser Tyr Asn Met Thr Thr Glu Ile Arg Asp 
145                 150                 155                 160 


Arg Lys Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Ile Val Pro 
                165                 170                 175     


Ile Asp Glu Glu Lys Asn Asn Asn Ser Val Thr Ser Pro Tyr Arg Leu 
            180                 185                 190         


Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser 
        195                 200                 205             


Phe Glu Pro Ile Pro Ile Tyr Tyr Cys Ala Pro Ala Gly Phe Ala Ile 
    210                 215                 220                 


Leu Lys Cys Lys Asp Ala Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Ile Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Asn Gly Thr Lys Ile Arg 
            260                 265                 270         


Ser Glu Asn Ile Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn 
        275                 280                 285             


Glu Thr Val Gln Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Arg 
    290                 295                 300                 


Ser Val Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Gly Ile 
305                 310                 315                 320 


Thr Gly Asp Ile Arg Arg Ala Tyr Cys Asn Val Ser Arg Gln Lys Trp 
                325                 330                 335     


Glu Gln Ala Leu Lys Gly Val Val Ile Gln Leu Arg Lys His Phe Asn 
            340                 345                 350         


Asn Lys Thr Ile Thr Phe Thr Asn Ser Ser Gly Gly Asp Val Glu Ile 
        355                 360                 365             


Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr 
    370                 375                 380                 


Ser Gly Leu Phe Asn Ser Thr Trp Asp Asn Asn Thr Asp Pro Thr Asn 
385                 390                 395                 400 


Thr Thr Ser Asn Asp Thr Ile Thr Leu Gln Cys Arg Ile Lys Gln Phe 
                405                 410                 415     


Ile Asn Met Trp Gln Arg Thr Gly Gln Ala Met Tyr Ala Pro Pro Ile 
            420                 425                 430         


Gln Gly Val Ile Arg Cys Asp Ser Asn Ile Thr Gly Leu Leu Leu Thr 
        435                 440                 445             


Arg Asp Gly Gly Val Gly Asn Asn Thr Thr Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Gly Ala Lys Arg 
                485                 490                 495     


Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe 
            500                 505                 510         


Ile Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Val 
        515                 520                 525             


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
    530                 535                 540                 


Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys 
545                 550                 555                 560 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
                565                 570                 575     


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
            580                 585                 590         


Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser 
        595                 600                 605             


Asn Lys Ser Gln Glu Glu Ile Trp Gly Asn Met Thr Trp Leu Gln Trp 
    610                 615                 620                 


Asp Lys Glu Ile Ser Lys Tyr Thr Gln Thr Ile Tyr Asp Leu Phe Glu 
625                 630                 635                 640 


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
                645                 650                 655     


Asp Lys Trp Ala Asn Leu Trp Thr Trp Phe Asp Ile Thr Asn Trp Leu 
            660                 665                 670         


Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu 
        675                 680                 685             


Arg Ile Val Phe Ser Val Leu Ser Val Ile Asn Arg Val Arg Gln Gly 
    690                 695                 700                 


Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Ser Pro Arg Gly Leu 
705                 710                 715                 720 


Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp 
                725                 730                 735     


Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp 
            740                 745                 750         


Leu Arg Asn Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile 
        755                 760                 765             


Leu Ile Ala Ala Arg Thr Val Glu Leu Leu Gly His Asn Ser Leu Lys 
    770                 775                 780                 


Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu 
785                 790                 795                 800 


Ile Tyr Trp Gly Arg Glu Leu Lys Phe Ser Ala Ile Asn Leu Ile Asp 
                805                 810                 815     


Thr Ile Ala Ile Ala Val Ala Gly Trp Thr Asp Arg Ile Ile Glu Ala 
            820                 825                 830         


Gly Gln Arg Leu Cys Arg Ala Ile Leu Asn Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Ala Glu Arg Ala Trp Leu 
    850                 855     


<210> 174
<211> 855
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 174
Met Arg Val Met Gly Thr Gln Arg Asn Cys Gln His Leu Leu Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Ile Ile Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asn Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Val Thr Ala Thr Ser Gly Thr Thr His Gly 
    130                 135                 140                 


Gly Arg Gly Arg Met Lys Asn Cys Ser Tyr Asn Ile Thr Thr Glu Leu 
145                 150                 155                 160 


Arg Asp Arg Arg Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val 
                165                 170                 175     


Val Pro Ile Asn Glu Asn Asn Ser Ser Asn Asn Glu Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Thr Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Thr Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Val Met Ile Arg Ser 
            260                 265                 270         


Glu Asn Ile Thr Asn Asn Ala Lys Asn Ile Ile Val Gln Phe Ala Glu 
        275                 280                 285             


Pro Val Lys Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Met Ser 
    290                 295                 300                 


Ile Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asn Ile Arg Gln Ala His Cys Asn Val Ser Arg Ala Glu Trp Asn 
                325                 330                 335     


Thr Thr Leu Gln Lys Val Val Thr Lys Leu Arg Glu Tyr Phe Gly Asn 
            340                 345                 350         


Asn Lys Thr Ile Lys Phe Ala Asn Ser Ser Gly Gly Asp Leu Glu Ile 
        355                 360                 365             


Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
    370                 375                 380                 


Ser Gly Leu Phe Asn Ser Thr Trp Thr Asn Met Gln Glu Ser Asn Ser 
385                 390                 395                 400 


Thr Glu Ser Asn Asp Thr Ile Thr Leu Pro Cys Arg Ile Lys Ile Ile 
                405                 410                 415     


Asn Met Trp Gln Arg Ala Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln 
            420                 425                 430         


Gly Ile Ile Lys Cys Val Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Asp Asn Asn Ser Glu Ser Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
465                 470                 475                 480 


Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg 
                485                 490                 495     


Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu 
            500                 505                 510         


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr 
        515                 520                 525             


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
    530                 535                 540                 


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu 
545                 550                 555                 560 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu 
                565                 570                 575     


Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
            580                 585                 590         


Lys Ile Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn 
        595                 600                 605             


Lys Ser Gln Ser Glu Ile Trp Glu Asn Met Thr Trp Leu Gln Trp Asp 
    610                 615                 620                 


Lys Glu Ile Ser Asn Tyr Thr Asp Ile Ile Tyr Asn Leu Leu Glu Glu 
625                 630                 635                 640 


Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp 
                645                 650                 655     


Lys Trp Ala Asn Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp 
            660                 665                 670         


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
        675                 680                 685             


Ile Val Phe Thr Val Leu Ser Ile Ile Asn Arg Val Arg Gln Gly Tyr 
    690                 695                 700                 


Ser Pro Leu Ser Phe Gln Thr His Thr Pro Ala Pro Arg Gly Leu Asp 
705                 710                 715                 720 


Arg Pro Glu Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg 
                725                 730                 735     


Ser Ile Arg Leu Val Thr Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu 
            740                 745                 750         


Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu 
        755                 760                 765             


Ile Ala Thr Glu Thr Val Glu Leu Leu Gly His Ser Ser Leu Arg Gly 
    770                 775                 780                 


Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Leu 
785                 790                 795                 800 


Tyr Trp Gly Gln Glu Leu Lys Ile Ser Ala Ser Asn Leu Val Asp Thr 
                805                 810                 815     


Ile Ala Ile Val Val Ala Gly Trp Thr Asp Arg Val Ile Glu Ile Ala 
            820                 825                 830         


Gln Gly Ile Gly Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln 
        835                 840                 845             


Gly Phe Glu Arg Ala Leu Leu 
    850                 855 


<210> 175
<211> 868
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 175
Met Arg Val Met Gly Ile Gln Met Asn Cys Gln Asn Leu Leu Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Leu Ile Ile Cys Ser Ala Thr Ser Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asp Pro 
65                  70                  75                  80  


Gln Glu Ile Tyr Leu Glu Asn Val Thr Glu Gly Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser His Asn Ile Thr Thr His Asn Ile Thr Thr Asn Asn Pro 
    130                 135                 140                 


Asn Ile Thr Lys Tyr Met Glu Gly Glu Ile Lys Asn Cys Ser Tyr Asn 
145                 150                 155                 160 


Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val Tyr Ser Leu Phe 
                165                 170                 175     


Tyr Lys Leu Asp Val Val Pro Ile Asp Lys Asn Asn Gly Asn Asn Asn 
            180                 185                 190         


Ile Arg Thr Gln Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Ala Glu Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Arg Pro Val Ile Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Glu Gly Arg Val Lys Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys 
        275                 280                 285             


Thr Ile Ile Val Gln Leu Asn Lys Thr Val Glu Ile Asn Cys Thr Arg 
    290                 295                 300                 


Pro Asn Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro Gly Gln Ala 
305                 310                 315                 320 


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys 
                325                 330                 335     


Asn Val Ser Arg Ala Asp Trp Asn Lys Thr Leu Gln Gly Val Ala Asn 
            340                 345                 350         


Gln Leu Lys Ser Tyr Phe Ser Asn Lys Thr Ile Ile Phe Ala Ser Ser 
        355                 360                 365             


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asp Thr Ser Gly Leu Phe Asn Ser Thr Trp Gly 
385                 390                 395                 400 


Gly Asn Ser Thr Asp Ser Ile Gln Glu Ser Asn Ser Thr Glu Ser Asn 
                405                 410                 415     


Asp Thr Ile Ile Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
            420                 425                 430         


Gln Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile 
        435                 440                 445             


Lys Cys Ile Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
    450                 455                 460                 


Asp Asn Asn Ser Ala Asn Glu Thr Phe Arg Pro Thr Gly Gly Asn Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
                485                 490                 495     


Glu Pro Leu Gly Val Ala Pro Thr Pro Ala Lys Arg Arg Val Val Gln 
            500                 505                 510         


Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Ile Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Thr Gln 
    610                 615                 620                 


Ser Glu Ile Trp Asn Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile 
625                 630                 635                 640 


Ser Asn Tyr Thr Asp Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Ile 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Ala Leu Asp Lys Trp Ala 
            660                 665                 670         


Asn Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile Arg 
        675                 680                 685             


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe 
    690                 695                 700                 


Ala Val Leu Ser Ile Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
705                 710                 715                 720 


Ser Phe Gln Ile His Thr Pro Asn Pro Arg Gly Pro Asp Arg Pro Glu 
                725                 730                 735     


Arg Ile Glu Glu Glu Gly Gly Glu Gln Gly Arg Asp Arg Ser Ile Arg 
            740                 745                 750         


Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu 
        755                 760                 765             


Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala 
    770                 775                 780                 


Arg Thr Val Glu Leu Leu Lys Arg Ser Ser Leu Arg Gly Leu Arg Leu 
785                 790                 795                 800 


Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Leu Tyr Trp Gly 
                805                 810                 815     


Arg Glu Leu Lys Asn Ser Ala Ile Asn Leu Leu Asp Thr Ile Ala Ile 
            820                 825                 830         


Ala Val Ala Gly Trp Thr Asp Arg Val Ile Glu Ile Gly Gln Ala Ile 
        835                 840                 845             


Cys Arg Ala Ile Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu 
    850                 855                 860                 


Arg Ala Leu Leu 
865             


<210> 176
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 176
Met Arg Ala Arg Gly Met Gln Arg Asn Trp Gln His Trp Gly Arg Trp 
1               5                   10                  15      


Gly Ile Leu Phe Leu Leu Ile Ile Tyr Ser Ala Ala Glu Asn Leu Trp 
            20                  25                  30          


Val Thr Val Tyr Cys Gly Val Pro Val Trp Lys Asp Ala Lys Thr Thr 
        35                  40                  45              


Leu Phe Cys Ala Ser Asp Ala Arg Ala Tyr His Pro Glu Ala His Asn 
    50                  55                  60                  


Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu 
65                  70                  75                  80  


Ile His Leu Glu Asn Val Thr Glu Lys Phe Asn Met Trp Lys Asn Asn 
                85                  90                  95      


Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser 
            100                 105                 110         


Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asp Cys 
        115                 120                 125             


His Asp Leu Asn Ser Ser Asn Ser Ser Asn Tyr Thr Ser Ser Asn Met 
    130                 135                 140                 


Gln Gly Glu Met Thr Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg 
145                 150                 155                 160 


Asp Lys Lys Gln Lys Val Asn Ala Phe Phe Tyr Arg Leu Asp Val Val 
                165                 170                 175     


Gln Ile Lys Glu Asn Asn Ser Thr Gln Tyr Arg Leu Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile 
        195                 200                 205             


Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn 
    210                 215                 220                 


Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val 
225                 230                 235                 240 


Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu 
                245                 250                 255     


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn Ile 
            260                 265                 270         


Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Ala Asn Pro Val Arg 
        275                 280                 285             


Ile Asn Cys Thr Arg Pro Gly Asn Asn Thr Arg Lys Ser Val Arg Ile 
    290                 295                 300                 


Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala His Cys Asn Val Asn Arg Thr Glu Trp Asp Ser Ser Leu 
                325                 330                 335     


Gln Lys Val Ala Thr Gln Leu Arg Gln Tyr Phe Lys Asn Thr Thr Lys 
            340                 345                 350         


Ile Ile Phe Thr Lys His Ser Gly Gly Asp Leu Glu Ile Thr Thr His 
        355                 360                 365             


Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu 
    370                 375                 380                 


Phe Asn Ser Thr Trp Asp Asn Asn Asn Ile Ala Ser Ser Asn His Thr 
385                 390                 395                 400 


Gly Ser Asn Asp Thr Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile 
                405                 410                 415     


Asn Leu Trp Gln Lys Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Pro 
            420                 425                 430         


Gly Ile Ile Arg Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Asn Asn Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
465                 470                 475                 480 


Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg 
                485                 490                 495     


Val Val Ala Arg Lys Lys Arg Ala Val Gly Leu Gly Ala Val Phe Leu 
            500                 505                 510         


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Ala 
        515                 520                 525             


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
    530                 535                 540                 


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Lys Leu 
545                 550                 555                 560 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu 
                565                 570                 575     


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
            580                 585                 590         


Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Gly Trp Ser Asn 
        595                 600                 605             


Lys Ser Gln Asn Glu Ile Trp Asp Lys Met Thr Trp Leu Glu Trp Asp 
    610                 615                 620                 


Lys Glu Ile Ser Asn Tyr Thr Gln Leu Ile Tyr Thr Leu Ile Glu Glu 
625                 630                 635                 640 


Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Ala Leu Asp 
                645                 650                 655     


Lys Trp Ala Ser Leu Trp Ser Trp Phe Asp Ile Ser Asn Trp Leu Trp 
            660                 665                 670         


Tyr Ile Lys Ile Phe Ile Met Val Val Gly Gly Leu Ile Gly Leu Arg 
        675                 680                 685             


Ile Val Phe Ala Val Leu Ser Val Val Arg Arg Val Arg Gln Gly Tyr 
    690                 695                 700                 


Ser Pro Leu Ser Leu Gln Thr Leu Ile Pro Ser Pro Arg Gly Pro Asp 
705                 710                 715                 720 


Arg Pro Glu Gly Ile Glu Glu Arg Gly Gly Glu Gln Asp Lys Asp Arg 
                725                 730                 735     


Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu 
            740                 745                 750         


Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu 
        755                 760                 765             


Ile Ala Ala Arg Ile Val Glu Thr Leu Gly His Arg Gly Trp Gln Gly 
    770                 775                 780                 


Leu Lys Tyr Leu Gly Asn Leu Val Gln Tyr Trp Ser Gln Glu Leu Lys 
785                 790                 795                 800 


Asn Ser Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile Ala Val Ala Glu 
                805                 810                 815     


Trp Thr Asp Arg Val Ile Glu Ile Gly Gln Arg Ile Cys Arg Ala Ile 
            820                 825                 830         


Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
        835                 840                 845             


<210> 177
<211> 862
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 177
Met Lys Val Arg Gly Thr Gln Arg Asn Tyr Ala Pro Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Ile Phe Leu Gly Leu Ile Ile Ile Cys Lys Ala Thr Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu 
        35                  40                  45              


Thr Ile Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Arg Asp Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Glu Leu Glu Asn Val Thr Glu Glu Phe Asn Met Gly Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Ile Cys Val Thr Leu 
        115                 120                 125             


Asn Cys His Asn Ile Thr Thr Asn Asp Thr Gly Thr Gly Asn Val Thr 
    130                 135                 140                 


Gly Thr Gly Asn Val Thr Asp Asn Asn Ile Gly Glu Met Thr Asn Cys 
145                 150                 155                 160 


Ser Phe Asn Ile Thr Thr Glu Ile Arg Asp Lys Arg Gln Asn Val Tyr 
                165                 170                 175     


Ser Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asn Gly Asn Gly Ser 
            180                 185                 190         


Gly Asn Asp Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr Ile 
        195                 200                 205             


Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr 
    210                 215                 220                 


Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Arg Asp Lys Asn Phe 
225                 230                 235                 240 


Asn Gly Thr Gly Pro Cys Arg Asn Val Ser Ser Val Gln Cys Thr His 
                245                 250                 255     


Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
            260                 265                 270         


Ala Glu Gly Asp Val Val Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala 
        275                 280                 285             


Lys Thr Ile Ile Val Gln Leu Asn Glu Ser Val Pro Ile Asn Cys Thr 
    290                 295                 300                 


Arg Pro Asn Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro Gly Gln 
305                 310                 315                 320 


Ala Leu Tyr Ala Thr Asp Ile Ile Gly Asn Ile Arg Gln Ala His Cys 
                325                 330                 335     


Asn Ile Ser Lys Gln Asn Trp Asn Thr Ala Leu Gln Lys Ile Ala Ala 
            340                 345                 350         


Gln Leu Arg Gln His Phe Tyr Arg Thr Ile Asn Phe Thr Lys Ser Ser 
        355                 360                 365             


Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asp Thr Ser Gly Leu Phe Asn Ser Ile Trp Asn Ser 
385                 390                 395                 400 


Thr Ala Ile Ser Gln Asn Val Glu Glu Ser Asn Asp Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Lys Ile Arg Gln Ile Val Asn Met Trp Gln Arg Val Gly Gln 
            420                 425                 430         


Ala Ile Tyr Ala Arg Pro Ile Gln Gly Ile Ile Asn Cys Thr Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asp Asn Asp Asn Lys 
    450                 455                 460                 


Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Arg Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Leu Gly Ala Val Ile Phe Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln Ala Thr Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Val Leu Ala Leu Glu Arg Tyr Leu Arg Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val 
        595                 600                 605             


Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Asn Glu Ile Trp Glu 
    610                 615                 620                 


Asn Met Thr Trp Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Asp Ile 
625                 630                 635                 640 


Ile Tyr Asp Leu Ile Ala Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
                645                 650                 655     


Lys Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
            660                 665                 670         


Asp Ile Ser Lys Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile Val 
        675                 680                 685             


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Thr Val Leu Ser Ile Ile 
    690                 695                 700                 


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Thr 
705                 710                 715                 720 


Pro Ser Pro Gly Gly Leu Asp Arg Pro Glu Arg Ile Glu Glu Glu Gly 
                725                 730                 735     


Gly Asp Arg Asp Arg Asp Arg Ser Thr Arg Leu Val Ser Gly Phe Leu 
            740                 745                 750         


Ala Leu Val Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
        755                 760                 765             


Arg Leu Arg Asp Phe Thr Leu Ile Ala Ala Arg Thr Val Glu Leu Leu 
    770                 775                 780                 


Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys 
785                 790                 795                 800 


Tyr Leu Trp Asn Leu Leu Ser Tyr Trp Gly Arg Glu Leu Lys Ser Ser 
                805                 810                 815     


Ala Ile Thr Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr 
            820                 825                 830         


Asp Arg Val Ile Glu Val Gly Gln Arg Ala Gly Arg Ala Leu Leu His 
        835                 840                 845             


Ile Pro Arg Arg Ile Arg Gln Gly Trp Lys Arg Ala Leu Leu 
    850                 855                 860         


<210> 178
<211> 880
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 178
Met Arg Val Met Gly Ile Gln Lys Asn Trp Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Met Ile Met Ile Cys Ser Thr Ala Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Thr Tyr Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


His Cys Thr Asp Val Asn Val Thr Asn Thr Asn Val Thr Asn Thr Asn 
    130                 135                 140                 


Gly Thr Ser Thr Ser Ser Ser Lys Val Thr Ile Asn Asp Arg Glu Glu 
145                 150                 155                 160 


Ile Lys Asn Cys Ser Phe Asn Val Thr Thr Glu Leu Arg Asp Lys Glu 
                165                 170                 175     


Lys Lys Val Tyr Ser Leu Phe Tyr Lys Leu Asp Val Val Lys Ile Asp 
            180                 185                 190         


Lys Asn Lys Ser Asp Tyr Ile Leu Ile Asn Cys Asn Thr Ser Thr Ile 
        195                 200                 205             


Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr 
    210                 215                 220                 


Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Arg Asp Ile Asp Phe 
225                 230                 235                 240 


Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His 
                245                 250                 255     


Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
            260                 265                 270         


Ala Glu Gly Gly Ile Arg Ile Arg Phe Glu Asn Ile Thr Asn Asn Ala 
        275                 280                 285             


Lys Thr Ile Ile Val Gln Leu Asn Ser Ser Val Pro Ile Asn Cys Thr 
    290                 295                 300                 


Arg Pro Asn Asn Asn Thr Arg Gln Ser Val Arg Ile Gly Pro Gly Gln 
305                 310                 315                 320 


Ser Phe Phe Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His 
                325                 330                 335     


Cys Asn Val Ser Lys Ser Asp Trp His Lys Thr Leu Gln Gln Val Ala 
            340                 345                 350         


Glu Gln Leu Glu Lys His Phe Lys Asn Lys Thr Ile Ile Phe Asp Gln 
        355                 360                 365             


Pro Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly 
    370                 375                 380                 


Gly Glu Phe Phe Tyr Cys Asn Thr Ala Gly Leu Phe Asn Arg Asn Trp 
385                 390                 395                 400 


Thr Trp Ser Lys Glu Asn Gly Thr Arg Met Gln Asn Lys Thr Asp Ser 
                405                 410                 415     


Asn Gly Thr Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn Met 
            420                 425                 430         


Trp Gln Arg Thr Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val 
        435                 440                 445             


Ile Lys Cys Ala Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
    450                 455                 460                 


Gly Asp Asn Lys Asn Asn Ser Thr Asn Ser Thr Asn Gln Asn Asn Thr 
465                 470                 475                 480 


Glu Ile Phe Arg Pro Ile Gly Gly Asp Met Arg Asn Asn Trp Arg Ser 
                485                 490                 495     


Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala 
            500                 505                 510         


Pro Thr Thr Ala Arg Arg Arg Val Val Gly Arg Glu Lys Arg Ala Val 
        515                 520                 525             


Leu Gly Gly Leu Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly 
    530                 535                 540                 


Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln 
545                 550                 555                 560 


Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile 
                565                 570                 575     


Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln 
            580                 585                 590         


Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln 
        595                 600                 605             


Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Pro Thr Asn 
    610                 615                 620                 


Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Thr Met Ser Glu Ile Trp 
625                 630                 635                 640 


Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr 
                645                 650                 655     


Asn Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 
            660                 665                 670         


Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn 
        675                 680                 685             


Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met 
    690                 695                 700                 


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Phe Ser 
705                 710                 715                 720 


Ile Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
                725                 730                 735     


His Pro Pro Asn Pro Gly Gly Leu Asp Arg Pro Gly Arg Ile Glu Glu 
            740                 745                 750         


Glu Gly Gly Glu Gln Asp Arg Gly Arg Ser Ile Arg Leu Val Ser Gly 
        755                 760                 765             


Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Ile Phe Ser 
    770                 775                 780                 


Tyr His Arg Leu Arg Asp Phe Thr Leu Ile Ala Glu Arg Thr Val Glu 
785                 790                 795                 800 


Leu Leu Gly His Asn Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly 
                805                 810                 815     


Leu Lys Tyr Leu Trp Asn Leu Leu Val Tyr Trp Gly Gln Glu Leu Lys 
            820                 825                 830         


Thr Ser Ala Ile Ser Leu Phe Asp Thr Leu Ala Ile Val Val Ala Gly 
        835                 840                 845             


Trp Thr Asp Arg Val Ile Glu Ile Gly Gln Arg Leu Gly Arg Gly Phe 
    850                 855                 860                 


Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Val Leu Leu 
865                 870                 875                 880 


<210> 179
<211> 846
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 179
Met Arg Val Arg Glu Ile Pro Arg Asn Cys Pro Leu Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Phe Trp Ile Leu Leu Ile Cys Asn Ala Glu Glu Leu 
            20                  25                  30          


Trp Val Thr Val Phe Tyr Gly Val Pro Val Trp Arg Asp Ala Glu Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His 
    50                  55                  60                  


Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Ile Gly Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Gln Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Ser His Asn Ile Ser Thr Thr Asn Ser Thr Ser Thr Gly Asn Ile 
    130                 135                 140                 


Ser Thr Ile Asn Ser Thr Ser Ala Asp Met Arg Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Asn Val Tyr Ser Leu Phe 
                165                 170                 175     


Tyr Lys Leu Asp Val Val Gln Ile Gly Asn Ser Ser Ser Ser Glu Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Ile Ser Thr Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr 
    210                 215                 220                 


Ala Ile Leu Lys Cys Arg Glu Lys Asn Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Asp Val Met 
            260                 265                 270         


Ile Arg Ser Glu Asn Ile Thr Asp Asn Ala Lys Thr Ile Ile Val Gln 
        275                 280                 285             


Phe Asn Glu Ser Val Met Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Arg Ser Val Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Glu Ile Ile Gly Asp Ile Arg Arg Ala His Cys Asn Val Ser Gly Glu 
                325                 330                 335     


Gln Trp Arg Lys Ala Leu Gln Asn Val Lys Val Gln Leu Arg Lys Tyr 
            340                 345                 350         


Phe Asn Thr Thr Ile Glu Phe Ala Asn Ser Ser Gly Gly Asp Leu Glu 
        355                 360                 365             


Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asp 
    370                 375                 380                 


Thr Thr Gly Leu Phe Asn Asn Thr Glu Lys Asn Asp Thr Ile Met Leu 
385                 390                 395                 400 


Pro Cys Lys Ile Arg Gln Ile Val Arg Met Trp Gln Arg Val Gly Gln 
                405                 410                 415     


Ala Met Tyr Ala Pro Pro Ile Pro Gly Val Ile Asn Cys Leu Ser Asn 
            420                 425                 430         


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asp Ser Thr Asn Asn 
        435                 440                 445             


Thr Glu Lys Phe Arg Pro Gly Gly Gly Asp Ile Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
465                 470                 475                 480 


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Arg Lys Arg Ala 
                485                 490                 495     


Gly Leu Ala Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr 
            500                 505                 510         


Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
        515                 520                 525             


Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Lys Ala Ile Glu Ala 
    530                 535                 540                 


Gln Gln Gln Met Leu Arg Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
545                 550                 555                 560 


Ala Arg Val Leu Ala Leu Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu 
                565                 570                 575     


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro 
            580                 585                 590         


Trp Asn Ser Ser Trp Ser Asn Lys Thr Tyr Asn Ser Ile Trp Asp Asn 
        595                 600                 605             


Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Asn Asn Tyr Thr Asn Thr 
    610                 615                 620                 


Ile Tyr Thr Leu Ile Glu Lys Ala Gln Asn Gln Gln Glu Lys Asn Glu 
625                 630                 635                 640 


Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
                645                 650                 655     


Asp Ile Thr Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Ala 
            660                 665                 670         


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile 
        675                 680                 685             


Asn Arg Val Arg Lys Gly Tyr Ser Pro Leu Ser Phe Gln Thr Pro Thr 
    690                 695                 700                 


Pro Asn Pro Gly Asp Leu Asp Arg Pro Glu Arg Ile Glu Glu Glu Gly 
705                 710                 715                 720 


Gly Glu Gln Gly Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu 
                725                 730                 735     


Ala Leu Val Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
            740                 745                 750         


Arg Leu Arg Asp Leu Val Leu Leu Thr Thr Arg Ala Val Glu Leu Leu 
        755                 760                 765             


Gly His Asn Ser Leu Lys Gly Leu Arg Leu Gly Trp Asn Val Leu Lys 
    770                 775                 780                 


Gln Leu Gly Asn Leu Leu Ser Tyr Trp Gly Gln Glu Leu Lys Asn Ser 
785                 790                 795                 800 


Ala Ile Asn Leu Leu Asp Thr Ile Ala Ile Ala Val Ala Asn Trp Thr 
                805                 810                 815     


Asp Arg Val Ile Glu Ile Gly Gln Arg Val Gly Arg Ala Ile Cys Asn 
            820                 825                 830         


Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Leu Leu Leu 
        835                 840                 845     


<210> 180
<211> 862
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 180
Met Lys Val Arg Gly Ile Gln Arg Asn Ser Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Leu Ile Phe Trp Thr Ile Ile Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser His Ala Asn Ala Tyr Glu Lys Glu Gln 
    50                  55                  60                  


His Ile Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Leu Glu Met Asp Leu Asp Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Ile His Asp Asp Ile Ile Arg Leu Trp Asp 
            100                 105                 110         


Arg Ser Leu Gln Pro Arg Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asp Cys Gln Pro Val Asn Ser Thr Asn Asn Thr Lys Val Glu Val Pro 
    130                 135                 140                 


Gly Glu Met Thr Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Ser Asp 
145                 150                 155                 160 


Lys Lys Gln Lys Val Arg Ser Leu Phe Tyr Arg Ile Asp Leu Val Gln 
                165                 170                 175     


Ile Gly Asn Asn Thr Asn Asp Ser Ser Asn Arg Ser Leu Gln Tyr Arg 
            180                 185                 190         


Leu Ile Asn Cys Asn Thr Ser Thr Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Val Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Lys Asp Gln Glu Phe Asn Gly Thr Gly Pro Cys Lys 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Gly Ile Lys Ile 
            260                 265                 270         


Arg Ser Ala Asn Ile Ser Tyr Asn Ala Lys Asn Ile Ile Val Gln Leu 
        275                 280                 285             


Asp Ile Pro Val Lys Ile Asn Cys Ser Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 


Thr Ser Val Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Asp 
305                 310                 315                 320 


Ile Ile Gly Asn Ile Arg Gln Ala His Cys Asn Leu Ser Arg Thr Ala 
                325                 330                 335     


Trp Asn Asp Thr Leu Tyr Asn Val Ser Lys Ala Leu Arg Glu His Phe 
            340                 345                 350         


Pro Asn Lys Thr Ile Ile Phe Asn Lys Ser Ser Gly Gly Asp Leu Glu 
        355                 360                 365             


Val Thr Gln His Met Phe Ile Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Ser Gly Leu Phe Asn Ser Ser Trp Ala Pro Asn Gly Ser Trp Ile 
385                 390                 395                 400 


Asn Asn Ile Gly Ser Arg Glu Asn Asp Thr Met Thr Leu Pro Cys Arg 
                405                 410                 415     


Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Val Glu Gln Ala Met Tyr 
            420                 425                 430         


Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Val Ser Asn Ile Thr Gly 
        435                 440                 445             


Leu Leu Leu Thr Arg Asp Gly Gly Thr Asn Glu Thr Arg Glu Asn Glu 
    450                 455                 460                 


Thr Phe Arg Pro Ile Gly Gly Glu Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Lys Ala Lys Arg Arg Val Val Glu Gly Arg Glu Lys Arg Ala Val 
            500                 505                 510         


Gly Met Gly Ala Phe Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr 
        515                 520                 525             


Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
    530                 535                 540                 


Ala Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala 
545                 550                 555                 560 


Gln Gln His Leu Leu Arg Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
                565                 570                 575     


Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
            580                 585                 590         


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val Pro 
        595                 600                 605             


Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Asp Glu Ile Trp Asn Asn 
    610                 615                 620                 


Met Thr Trp Met Gln Trp Asp Lys Glu Ile Asn Asn Tyr Thr Glu Ile 
625                 630                 635                 640 


Ile Tyr Gly Leu Ile Glu Glu Ser Gln Lys Gln Gln Glu Lys Asn Glu 
                645                 650                 655     


Phe Glu Leu Leu Glu Leu Asp Lys Trp Ala Asn Leu Trp Asn Trp Phe 
            660                 665                 670         


Glu Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
        675                 680                 685             


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val 
    690                 695                 700                 


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Pro Ile 
705                 710                 715                 720 


Pro Ser Pro Glu Gly Pro Asp Arg Pro Gly Arg Ile Glu Glu Gly Gly 
                725                 730                 735     


Gly Glu Gln Gly Arg Thr Arg Ser Ile Arg Leu Val Ser Gly Phe Leu 
            740                 745                 750         


Glu Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Val Tyr His 
        755                 760                 765             


Arg Ser Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu 
    770                 775                 780                 


Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys 
785                 790                 795                 800 


Tyr Leu Trp Asn Leu Leu Val Tyr Trp Ser Gln Glu Leu Lys Thr Ser 
                805                 810                 815     


Ala Val Ser Ala Phe Asn Ala Leu Ala Ile Thr Val Ala Glu Trp Thr 
            820                 825                 830         


Asp Arg Ala Ile Glu Val Gly Gln Arg Ile Gly Arg Ala Phe Leu Asn 
        835                 840                 845             


Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
    850                 855                 860         


<210> 181
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 181
Met Lys Val Lys Gly Ile Gln Met Asn Ser Gln His Leu Leu Arg Trp 
1               5                   10                  15      


Gly Ile Met Ile Leu Gly Leu Ile Ile Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Asn Val Tyr Tyr Gly Val Pro Val Trp Lys Asn Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asn Pro Glu Ala 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Ile Tyr Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Ala Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Gln Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Glu Cys Lys Lys Ile Asn Ile Thr Asn Thr Thr Gly Asn Asn Val Thr 
    130                 135                 140                 


Ala Asn Asn Asp Thr Ile Leu Ala Arg Glu Glu Met Arg Asn Cys Ser 
145                 150                 155                 160 


Tyr Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val His Ser 
                165                 170                 175     


Leu Phe Tyr Arg Leu Asp Ile Val Glu Ile Asn Asn Asn Asn Asn Gly 
            180                 185                 190         


Ser Ser Asn Asn Asn Ser Asp Asn Asp Ser Arg Pro Tyr Arg Leu Ile 
        195                 200                 205             


Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Ile Ser Phe 
    210                 215                 220                 


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
225                 230                 235                 240 


Lys Cys Arg Asp Lys Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
                245                 250                 255     


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
            260                 265                 270         


Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Arg Val Met Ile Arg Thr 
        275                 280                 285             


Glu Asn Ile Thr Asn Asn Ala Lys Asn Ile Ile Val Gln Phe Asn Glu 
    290                 295                 300                 


Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Gln Ser 
305                 310                 315                 320 


Val Arg Ile Gly Pro Gly Gln Ala Phe Tyr Thr Thr Glu Ile Ile Gly 
                325                 330                 335     


Asp Ile Arg Arg Ala Tyr Cys Thr Val Asn Glu Thr Lys Trp Asn Gln 
            340                 345                 350         


Thr Leu Tyr Arg Val Ala Glu Gln Leu Arg Lys Tyr Phe Asn Asn Asp 
        355                 360                 365             


Thr Thr Ile Ile Phe Ala Asn Ser Ser Gly Gly Asp Val Glu Ile Thr 
    370                 375                 380                 


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
385                 390                 395                 400 


Gly Leu Phe Asn Ser Arg Trp Glu Asn Asp Thr Gln Pro Asn Asn Thr 
                405                 410                 415     


Gln Pro Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
            420                 425                 430         


Asn Met Trp Gln Arg Thr Gly Gln Ala Ile Tyr Ala Pro Pro Ile Arg 
        435                 440                 445             


Gly Val Ile Ser Cys Gln Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
    450                 455                 460                 


Asp Gly Gly Gly Lys Asn Thr Ser Asp Asn Glu Thr Phe Arg Pro Gly 
465                 470                 475                 480 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
                485                 490                 495     


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Asn Arg Ala Arg Arg 
            500                 505                 510         


Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe 
        515                 520                 525             


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met 
    530                 535                 540                 


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
545                 550                 555                 560 


Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys 
                565                 570                 575     


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Leu Leu Ala Val 
            580                 585                 590         


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
        595                 600                 605             


Gly Lys Leu Ile Cys Ala Thr Asn Val Pro Trp Asn Ser Ser Trp Ser 
    610                 615                 620                 


Asn Lys Ser Tyr Asp Glu Ile Trp Gly Asn Met Thr Trp Leu Gln Trp 
625                 630                 635                 640 


Asp Lys Glu Ile Asp Asn Tyr Thr Gln Leu Ile Tyr Gln Leu Ile Glu 
                645                 650                 655     


Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Ala Leu 
            660                 665                 670         


Asp Lys Trp Ala Asn Leu Trp Asn Trp Phe Glu Ile Ser Asn Trp Leu 
        675                 680                 685             


Trp Tyr Ile Arg Leu Phe Val Met Ile Val Gly Gly Leu Ile Gly Leu 
    690                 695                 700                 


Arg Ile Val Leu Ala Val Leu Ser Val Ile Asn Arg Val Arg Gln Gly 
705                 710                 715                 720 


Tyr Ser Pro Leu Ser Phe Gln Thr His Thr Pro Ser Pro Gly Gly Leu 
                725                 730                 735     


Asp Arg Pro Arg Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Gly 
            740                 745                 750         


Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp 
        755                 760                 765             


Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Val 
    770                 775                 780                 


Leu Ile Ala Ala Arg Ile Val Glu Leu Leu Gly His Asn Ser Leu Lys 
785                 790                 795                 800 


Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu 
                805                 810                 815     


Ala Tyr Trp Gly Arg Glu Leu Lys Asn Ser Ala Ile Asn Leu Leu Asp 
            820                 825                 830         


Thr Ile Ala Ile Ala Val Ala Gly Trp Thr Asp Arg Val Ile Glu Leu 
        835                 840                 845             


Gly Gln Arg Leu Cys Arg Ala Phe Leu His Ile Pro Arg Arg Ile Arg 
    850                 855                 860                 


Gln Gly Phe Glu Arg Ala Leu Leu 
865                 870         


<210> 182
<211> 863
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 182
Met Lys Val Lys Gly Thr Gln Arg Asn Phe Gln His Leu Leu Arg Trp 
1               5                   10                  15      


Gly Ile Met Val Leu Gly Met Ile Ile Ile Cys Ser Ala Thr Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Glu Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Glu Leu Lys Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Phe Ser Val Thr Asn Asn Ser Thr Asn Asn Ser Thr 
    130                 135                 140                 


Asn Thr Thr Thr Ile Asp Asn Asn Met Gln Gly Glu Ile Lys Asn Cys 
145                 150                 155                 160 


Ser Tyr Asn Val Thr Thr Val Ile Arg Asp Glu Lys Gln Lys Val Tyr 
                165                 170                 175     


Ser Leu Phe Tyr Arg Thr Asp Val Val Glu Ile Glu Asn Asn Ser Ser 
            180                 185                 190         


Gln Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
    210                 215                 220                 


Gly Phe Ala Ile Leu Lys Cys Arg Asn Glu Thr Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu 
            260                 265                 270         


Ile Met Ile Arg Ser Glu Asn Ile Ser Asp Asn Ala Lys Ser Ile Leu 
        275                 280                 285             


Val Gln Leu Thr Arg Pro Val Ile Ile Asn Cys Thr Arg Pro Asn Asn 
    290                 295                 300                 


Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Gln Ala Phe Tyr Ala 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys Thr Val Asn 
                325                 330                 335     


Arg Thr Glu Trp Asn Glu Thr Leu His Asn Val Thr Thr Gln Leu Lys 
            340                 345                 350         


Thr Tyr Phe Asn Lys Thr Ile Val Phe Thr Ser His Ser Gly Gly Asp 
        355                 360                 365             


Leu Glu Ile Thr Thr His Thr Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Asp Asp Asn Ile Lys 
385                 390                 395                 400 


Asn Asp Thr Asn Ser Thr Gln Gly Ser Asn Ser Thr Glu Ile Ile Leu 
                405                 410                 415     


Pro Cys Lys Ile Lys Gln Ile Val Arg Met Trp Gln Arg Thr Gly Gln 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Pro Gly Val Ile Arg Cys Val Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Thr Ser Ser Ile 
    450                 455                 460                 


Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Arg Arg Arg Val Val Glu Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Val Leu Phe Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ala Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln Gln Met Leu Arg Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val 
        595                 600                 605             


Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Asn Glu Ile Trp Asn 
    610                 615                 620                 


Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Gln 
625                 630                 635                 640 


Ile Ile Tyr Asp Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     


Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Ser Trp 
            660                 665                 670         


Phe Asp Ile Ser Ser Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Ile Lys Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Ile His 
705                 710                 715                 720 


Thr Pro Asn Pro Gly Glu Pro Asp Arg Pro Gly Glu Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Lys Gln Asp Arg Ser Arg Ser Ile Arg Leu Val Ser Gly Phe 
            740                 745                 750         


Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Cys Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu 
    770                 775                 780                 


Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu 
785                 790                 795                 800 


Lys Tyr Leu Trp Asn Leu Leu Val Tyr Trp Ser Gln Glu Leu Lys Ser 
                805                 810                 815     


Ser Ala Ile Asn Leu Phe Asp Thr Leu Ala Ile Thr Val Ala Gly Trp 
            820                 825                 830         


Thr Asp Arg Val Ile Glu Val Gly Gln Arg Leu Cys Arg Ala Leu Leu 
        835                 840                 845             


His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
    850                 855                 860             


<210> 183
<211> 854
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 183
Met Arg Val Lys Gly Ile Gln Met Asn Trp Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Gly Ile Ile Cys Asn Ala Glu Asn Leu 
            20                  25                  30          


Trp Val Thr Val Phe Tyr Gly Val Pro Val Trp Lys Asp Ala Glu Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Ser Glu Glu Lys His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asp Pro Lys 
65                  70                  75                  80  


Glu Ile Asn Leu Val Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Lys Met Val Glu Gln Met Gln Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Glu 
        115                 120                 125             


Cys His Asn Ser Thr Thr Pro Asp Asn Asn Thr Thr Gln Ser Thr Ile 
    130                 135                 140                 


Ile Asp Glu Thr Thr Asn Cys Thr Tyr Asn Met Thr Thr Glu Leu Arg 
145                 150                 155                 160 


Asp Lys Val Gln Lys Val His Ser Leu Phe Tyr Arg Leu Asp Val Val 
                165                 170                 175     


Gln Ile Asn Gly Ile Asn Gly Thr Ser Asn Asn Asn Ser Ala Gln Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe 
    210                 215                 220                 


Ala Ile Leu Lys Cys Arg Asp Lys Glu Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Arg Asn Val Ser Ser Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Lys Ile Met 
            260                 265                 270         


Ile Arg Ser Glu Asn Phe Thr Asp Asn Gly Lys Thr Ile Ile Val Gln 
        275                 280                 285             


Leu Val Glu Pro Val Lys Ile Asn Cys Thr Arg Pro Ser Asn Asn Thr 
    290                 295                 300                 


Arg Lys Gly Ile His Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Gln Ile Thr Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Thr 
                325                 330                 335     


Glu Trp Asn Lys Thr Leu His Gln Val Ala Ile Gln Leu Arg Glu His 
            340                 345                 350         


Phe Ile Thr Lys Asn Thr Thr Ile Ile Phe Asn Ser Ser Ser Gly Gly 
        355                 360                 365             


Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe 
    370                 375                 380                 


Tyr Cys Ser Thr Ser Gly Leu Phe Asn Ser Thr Trp Glu Asn Gly Thr 
385                 390                 395                 400 


Gln Val Ala Asn Asp Thr Gly Ser Asn Asp Thr Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Lys Gln Ile Val Arg Met Trp Gln Arg Val Gly Gln Ala Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Gln Gly Met Ile Arg Cys Glu Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Ile Leu Thr Arg Asp Gly Val Gly Asn Asn Ser Thr Asn Glu 
    450                 455                 460                 


Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Ser Arg Ala Lys Arg Arg Val Val Ala Arg Glu Lys Arg Ala Val Gly 
            500                 505                 510         


Leu Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
        515                 520                 525             


Gly Ala Ala Ser Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
    530                 535                 540                 


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln 
545                 550                 555                 560 


His His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
                565                 570                 575     


Arg Val Leu Ala Leu Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly 
            580                 585                 590         


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Pro Thr Asn Val Pro Trp 
        595                 600                 605             


Asn Tyr Ser Trp Ser Asn Lys Ser Tyr Asp Asp Ile Trp Asn Asn Met 
    610                 615                 620                 


Thr Trp Leu Gln Trp Asp Lys Glu Ile Asp Asn Tyr Thr Gln Leu Ile 
625                 630                 635                 640 


Tyr Gly Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 
                645                 650                 655     


Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Ser Trp Phe Asp 
            660                 665                 670         


Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val Gly 
        675                 680                 685             


Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile Asn 
    690                 695                 700                 


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Pro His 
705                 710                 715                 720 


His Gln Arg Glu Pro Asp Arg Pro Glu Gly Ile Glu Glu Gly Gly Gly 
                725                 730                 735     


Glu Gln Asp Arg Gly Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala 
            740                 745                 750         


Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg 
        755                 760                 765             


Leu Arg Asp Phe Ile Leu Ile Val Ala Arg Ile Val Glu Thr Leu Gly 
    770                 775                 780                 


Arg Arg Gly Trp Glu Ala Leu Lys Tyr Leu Trp Asn Leu Leu Leu Tyr 
785                 790                 795                 800 


Trp Gly Arg Glu Leu Lys Ile Ser Ala Ile Thr Leu Leu Asp Ala Thr 
                805                 810                 815     


Ala Ile Ala Val Ala Arg Trp Thr Asp Arg Ile Ile Glu Ile Gly Gln 
            820                 825                 830         


Arg Ile Val Arg Ala Ile Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly 
        835                 840                 845             


Ala Glu Lys Ala Leu Gln 
    850                 


<210> 184
<211> 865
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 184
Met Arg Ala Arg Gly Ile Gln Arg Asn Tyr Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Phe Gly Met Leu Met Ile Cys Asn Ala Val Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Thr Tyr Asp Gln Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asp Pro 
65                  70                  75                  80  


Gln Glu Ile Asp Leu Arg Asn Val Thr Glu Lys Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Gln Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ile Thr Asn Ile Ser Asn Asn Asn Asn Thr Asp Ser 
    130                 135                 140                 


Arg Asn Ile Thr His Ser Glu Asp Pro Ala Glu Met Arg Asn Cys Ser 
145                 150                 155                 160 


Phe Asn Val Ala Thr Gly Ile Arg Asp Arg Lys Lys Lys Val Tyr Ser 
                165                 170                 175     


Leu Phe Tyr Arg Leu Asp Ile Thr Pro Ile Asn Gly Ser Asp Asp Ser 
            180                 185                 190         


Lys Ser Ser Gly Gln Tyr Ile Leu Ile Asn Cys Asn Thr Ser Thr Ile 
        195                 200                 205             


Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr 
    210                 215                 220                 


Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Gln Phe 
225                 230                 235                 240 


Asn Gly Thr Gly Thr Cys Asn Asn Val Ser Pro Val Gln Cys Thr His 
                245                 250                 255     


Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
            260                 265                 270         


Pro Glu Gly Gly Val Ile Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala 
        275                 280                 285             


Lys Thr Ile Ile Val Gln Leu Asp Glu Pro Val Arg Ile Asn Cys Thr 
    290                 295                 300                 


Arg Pro Asn Asn Asn Thr Arg Lys Gly Ile His Ile Gly Pro Gly Gly 
305                 310                 315                 320 


Ala Phe Tyr Ala Thr Gly Glu Val Val Gly Asn Ile Arg His Ala Trp 
                325                 330                 335     


Cys Glu Val Asn Gly Thr Ala Trp Lys Glu Ala Leu Lys Lys Val Val 
            340                 345                 350         


Thr Lys Leu Lys Glu His Phe Lys Asn Lys Thr Ile Ala Phe Gln Pro 
        355                 360                 365             


Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg 
    370                 375                 380                 


Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Pro Gly Asn Thr Ser Glu Ser Asn Val Asn Thr Thr Gly Asn Ile Thr 
                405                 410                 415     


Leu Pro Cys Lys Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Val Gly 
            420                 425                 430         


Gln Ala Met Tyr Ala Pro Pro Ile Pro Gly Ile Ile Gln Cys Ile Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Ile Thr Arg Asp Gly Gly Asn Asn Asp Asn 
    450                 455                 460                 


Asn Val Thr Glu Ile Phe Ser Pro Gly Gly Gly Asp Met Arg Asp Asn 
465                 470                 475                 480 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Glu Pro Leu 
                485                 490                 495     


Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys 
            500                 505                 510         


Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Ala Ala Ala 
        515                 520                 525             


Gly Ser Ser Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg 
    530                 535                 540                 


Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Lys Ala 
545                 550                 555                 560 


Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys 
                565                 570                 575     


Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 
            580                 585                 590         


Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr 
        595                 600                 605             


Thr Val Pro Trp Asn Thr Thr Trp Ser Asn Lys Thr Leu Thr Asp Ile 
    610                 615                 620                 


Trp Asp Asn Met Thr Trp Leu Glu Trp Asp Arg Glu Ile Arg Gln Tyr 
625                 630                 635                 640 


Thr Gly Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 
                645                 650                 655     


Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Thr Leu Trp 
            660                 665                 670         


Ser Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile 
        675                 680                 685             


Ile Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Phe 
    690                 695                 700                 


Ser Ile Val Lys Lys Ala Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln 
705                 710                 715                 720 


Ile Leu Gly Pro Asn Pro Gly Gly Pro Asp Arg Pro Glu Arg Ile Lys 
                725                 730                 735     


Glu Glu Gly Gly Glu Gln Gly Arg Asp Arg Ser Ile Arg Leu Ala Ser 
            740                 745                 750         


Gly Phe Leu Ala Leu Val Trp Asp Asp Leu Arg Ser Leu Gly Ile Cys 
        755                 760                 765             


Ser Tyr His Arg Leu Arg Asp Phe Val Leu Ile Ala Thr Arg Thr Val 
    770                 775                 780                 


Glu Leu Leu Gly Arg Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu 
785                 790                 795                 800 


Gly Leu Lys Tyr Leu Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu 
                805                 810                 815     


Lys Asn Ser Ala Ile Ser Leu Leu Gly Ala Ile Ala Ile Ala Val Ala 
            820                 825                 830         


Glu Gly Thr Asp Arg Val Ile Thr Val Gly Gln Arg Ile Cys Arg Ala 
        835                 840                 845             


Ile Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu 
    850                 855                 860                 


Leu 
865 


<210> 185
<211> 868
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 185
Met Arg Ala Arg Gly Ile Gln Arg Asn Tyr Gln His Leu Leu Arg Trp 
1               5                   10                  15      


Gly Thr Ile Ile Leu Gly Met Ile Leu Ile Cys Ser Thr Thr Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Met 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Tyr Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Gln Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Ala Asn Ala Asn Ser Ile Asn Ala Asn Ala Thr Ser 
    130                 135                 140                 


Thr Asn Ala Thr Ala Glu Asn Glu Lys Gly Glu Ile Lys Asn Cys Ser 
145                 150                 155                 160 


Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Lys Lys Val Tyr Ser 
                165                 170                 175     


Leu Phe Tyr Arg Leu Asp Val Ile Pro Leu Asn Gly Thr Glu Asn Glu 
            180                 185                 190         


Thr Tyr Thr Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Arg Asp Glu Lys Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Lys Glu Glu Val Arg Ile Arg Ser Glu Asn Ile Thr Asn Asn Val Lys 
        275                 280                 285             


Thr Ile Ile Val Gln Leu Val Lys Pro Val Asn Ile Thr Cys Ile Arg 
    290                 295                 300                 


Pro Asn Asn Asn Thr Arg Lys Ser Ile His Leu Gly Pro Gly Arg Ala 
305                 310                 315                 320 


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asn Ile Arg Lys Ala His Cys 
                325                 330                 335     


Ile Val Asn Glu Ser Glu Trp Asn Glu Ala Leu Gln Gln Val Ala Thr 
            340                 345                 350         


Gln Leu Gly Lys Tyr Phe Glu Asn Lys Thr Ile Asn Phe Thr Ser Pro 
        355                 360                 365             


Ser Gly Gly Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Val 
385                 390                 395                 400 


Ser Asn Asn Thr Gly Lys Tyr Tyr Ser Asn Ser Thr Arg Glu Asn Pro 
                405                 410                 415     


Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
            420                 425                 430         


Arg Ala Gly Gln Ala Ile Tyr Ala Pro Pro Ile Glu Gly Val Ile Arg 
        435                 440                 445             


Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asp 
    450                 455                 460                 


Lys Asn Asn Thr Ser Glu Ile Phe Arg Pro Gly Gly Gly Asn Met Lys 
465                 470                 475                 480 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
                485                 490                 495     


Pro Leu Gly Val Ala Pro Thr Pro Ala Arg Arg Arg Val Val Gln Arg 
            500                 505                 510         


Glu Lys Arg Ala Val Phe Gly Leu Gly Ala Val Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Asn Val Pro Trp Asn Ser Thr Trp Ser Asn Lys Ser Tyr 
    610                 615                 620                 


Ser Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile 
625                 630                 635                 640 


Ser Asn Tyr Thr Gln Thr Ile Tyr Asn Leu Ile Glu Lys Ser Gln Ile 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Thr 
            660                 665                 670         


Asn Leu Trp Thr Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
        675                 680                 685             


Ile Phe Ile Met Ile Ile Gly Gly Leu Ile Gly Leu Arg Ile Val Phe 
    690                 695                 700                 


Ala Val Leu Ser Ala Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
705                 710                 715                 720 


Ser Phe Gln Thr His Thr Pro Asn Pro Glu Gly Leu Asp Arg Pro Gly 
                725                 730                 735     


Arg Ile Glu Glu Glu Gly Gly Glu Gln Gly Arg Gly Arg Ser Ile Arg 
            740                 745                 750         


Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu 
        755                 760                 765             


Cys Leu Phe Ser Tyr His Arg Leu Lys Asp Phe Ile Leu Ile Ala Ala 
    770                 775                 780                 


Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu 
785                 790                 795                 800 


Gly Trp Glu Gly Leu Lys Tyr Leu Gly Asn Leu Leu Leu Tyr Trp Gly 
                805                 810                 815     


Arg Glu Leu Arg Ile Ser Ala Ser Asp Leu Leu Asp Thr Ile Ala Ile 
            820                 825                 830         


Ala Val Ala Gly Trp Thr Asp Arg Val Ile Glu Ile Gly Gln Arg Ile 
        835                 840                 845             


Gly Arg Ala Ile Leu Asn Ile Pro Arg Arg Thr Arg Gln Gly Leu Glu 
    850                 855                 860                 


Arg Ala Leu Val 
865             


<210> 186
<211> 855
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 186
Met Arg Val Met Gly Ile Gln Arg Asn Trp Gln His Leu Leu Ser Trp 
1               5                   10                  15      


Gly Thr Met Val Leu Gly Met Ile Ile Ile Cys Ser Ala Val Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Gln 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Pro Leu Lys Asn Val Thr Glu Gln Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Glu Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Thr Ile Thr Leu Asn Asn Thr Asp Thr His Ser Thr Asn 
    130                 135                 140                 


Asn Thr Asp Ile Asp Ala Met Arg Asn Cys Ser Phe Asn Val Thr Thr 
145                 150                 155                 160 


Glu Leu Arg Asp Lys Thr Lys Arg Val Tyr Ser Leu Phe Tyr Arg Leu 
                165                 170                 175     


Asp Ile Val Gln Ile Asp Gly Asn Asn Ser Asn Gly Ser Gly Glu Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Glu Lys Glu Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Lys Asn Val Ala Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Lys Val Met 
            260                 265                 270         


Ile Arg Ser Glu Asn Ile Thr Asp Asn Ser Lys Asn Ile Ile Val Gln 
        275                 280                 285             


Phe Asn Lys Thr Val Thr Ile Asn Cys Thr Arg Pro Asn Asn Lys Thr 
    290                 295                 300                 


Lys Ile Arg Ser Ile His Ile Gly Pro Gly Arg Val Phe Gln Ala Thr 
305                 310                 315                 320 


Gln Thr Gly Asp Met Arg Lys Ala Phe Cys Thr Val Asn Lys Thr Glu 
                325                 330                 335     


Trp Asp Lys Thr Leu Glu Glu Val Ala Lys Gln Leu Arg Ala His Phe 
            340                 345                 350         


Asn Asn Lys Thr Ile Ile Phe Lys Ser Ser Ser Gly Gly Asp Ile Glu 
        355                 360                 365             


Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Ser Gly Leu Phe Asn Ser Thr Trp Glu Ala Asn Ser Thr Ala Asn 
385                 390                 395                 400 


Thr Ser Thr Thr Asn Ile Thr Leu Pro Cys Lys Ile Lys Gln Leu Val 
                405                 410                 415     


Arg Met Trp Gln Arg Thr Gly Gln Ala Leu Tyr Ala Pro Pro Ile Glu 
            420                 425                 430         


Gly Val Ile Lys Cys Val Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Gly Asn Asn Ser Ala Thr Asn Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Glu Ala Arg Arg 
                485                 490                 495     


Arg Val Val Lys Arg Glu Lys Arg Ala Val Pro Gly Leu Phe Phe Leu 
            500                 505                 510         


Gly Phe Leu Ala Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr 
        515                 520                 525             


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
    530                 535                 540                 


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu 
545                 550                 555                 560 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Thr Val Glu 
                565                 570                 575     


Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
            580                 585                 590         


Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn 
        595                 600                 605             


Lys Ser Gln Thr Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp 
    610                 615                 620                 


Lys Glu Ile Ser Asn Tyr Thr Gln Gln Ile Tyr Lys Leu Leu Glu Glu 
625                 630                 635                 640 


Ser Gln Asn Gln Gln Glu Gln Asn Glu Gln Asp Leu Leu Ala Leu Asp 
                645                 650                 655     


Lys Trp Ala Ser Leu Trp Asn Trp Phe Glu Ile Ser Asn Trp Leu Trp 
            660                 665                 670         


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
        675                 680                 685             


Ile Val Phe Ala Val Leu Ser Ile Ile Asn Arg Val Arg Gln Gly Tyr 
    690                 695                 700                 


Ser Pro Leu Ser Phe Gln Thr Gln Phe Pro Asn Pro Ala Gly Pro Gly 
705                 710                 715                 720 


Arg Pro Gly Arg Ile Glu Glu Glu Ser Gly Glu Gln Asp Arg Asp Arg 
                725                 730                 735     


Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu 
            740                 745                 750         


Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu 
        755                 760                 765             


Ile Val Ala Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly 
    770                 775                 780                 


Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu Gly Asn Leu Leu Ile 
785                 790                 795                 800 


Tyr Trp Gly Arg Glu Leu Lys Leu Ser Ala Ile Asn Leu Phe Asp Thr 
                805                 810                 815     


Ile Ala Ile Val Val Ala Gly Trp Thr Asp Arg Val Ile Glu Leu Gly 
            820                 825                 830         


Gln Arg Ile Val Arg Gly Phe Leu His Ile Pro Arg Arg Ile Arg Gln 
        835                 840                 845             


Gly Leu Glu Arg Ala Leu Leu 
    850                 855 


<210> 187
<211> 856
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 187
Met Lys Val Arg Gly Ile Gln Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Val Ile Met Met Cys Lys Gly Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Asn 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Glu Ala Thr Phe Asp Asn Asn Val Thr Asp Ser Met Lys 
    130                 135                 140                 


Lys Glu Met Lys Lys Cys Ser Phe Asn Thr Thr Thr Glu Ile Arg Asp 
145                 150                 155                 160 


Arg Lys Gln Gln Ala His Ala Leu Phe Tyr Lys Leu Asp Leu Val Pro 
                165                 170                 175     


Leu Asn Gly Ser Ser Ser Gly Tyr Gly Asn Tyr Ile Leu Ile Asn Cys 
            180                 185                 190         


Asn Thr Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro 
        195                 200                 205             


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
    210                 215                 220                 


Lys Asp Glu Ala Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Gly Ser Leu Ala Lys Gly Gly Ile Arg Ile Arg Ser Lys Asn 
            260                 265                 270         


Ile Thr Asn Asn Ala Gln Thr Ile Ile Val Gln Leu Ser Lys Pro Val 
        275                 280                 285             


Lys Ile Asn Cys Thr Arg Tyr Asn Asn Asn Thr Arg Glu Ser Ile Arg 
    290                 295                 300                 


Ile Gly Pro Gly Gln Thr Phe Tyr Thr Asn Lys Val Ile Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala His Cys Asn Ile Ser Glu Thr Glu Trp Asn Asn Thr Leu 
                325                 330                 335     


Gln Glu Val Ala Lys Gln Leu Val Val His Phe Pro Asn Lys Thr Ile 
            340                 345                 350         


Thr Phe Ala Pro Ala Ala Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe 
    370                 375                 380                 


Asn Asp Thr Phe Met Pro Asn Asn Thr Ala Asn Ser Thr Lys Asn Glu 
385                 390                 395                 400 


Thr Gln Glu Lys Asn Ile Thr Ile Ser Cys Lys Ile Lys Gln Ile Ile 
                405                 410                 415     


Arg Ile Trp Gln Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Glu 
            420                 425                 430         


Gly Leu Ile Lys Cys Glu Ser Asn Ile Thr Gly Ile Leu Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Asn Asn Thr Asn Ser Thr Glu Val Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Asn Tyr Lys Val 
465                 470                 475                 480 


Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Gly Ala Arg Arg Arg 
                485                 490                 495     


Val Val Glu Arg Glu Lys Arg Ala Val Val Gly Leu Gly Ala Val Phe 
            500                 505                 510         


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu 
        515                 520                 525             


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ala Gly Ile Val Gln Gln 
    530                 535                 540                 


Gln Ser Asn Leu Leu Gln Ala Ile Glu Ala Gln Gln His Met Leu Lys 
545                 550                 555                 560 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Leu 
                565                 570                 575     


Glu Arg Tyr Leu Gln Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
            580                 585                 590         


Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp Ser 
        595                 600                 605             


Asn Lys Ser Gln Glu Glu Ile Trp Lys Asn Met Thr Trp Leu Gln Trp 
    610                 615                 620                 


Asp Lys Glu Ile Ser Lys Tyr Thr Gly Ile Ile Tyr Thr Leu Leu Gln 
625                 630                 635                 640 


Glu Ser Gln Ser Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
                645                 650                 655     


Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu 
            660                 665                 670         


Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu 
        675                 680                 685             


Arg Ile Val Phe Ala Val Ile Ser Val Val Asn Arg Val Arg Lys Gly 
    690                 695                 700                 


Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Asn Gln Glu Gly Leu 
705                 710                 715                 720 


Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Gly Arg Gly 
                725                 730                 735     


Arg Ser Ile Arg Leu Val Ser Gly Phe Phe Ser Leu Ala Trp Asp Asp 
            740                 745                 750         


Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu 
        755                 760                 765             


Leu Ile Ala Ala Arg Thr Val Glu His Leu Gly Ser Ser Leu Leu Lys 
    770                 775                 780                 


Gly Leu Arg Leu Ala Arg Glu Gly Leu Asn Gln Leu Trp Asn Leu Leu 
785                 790                 795                 800 


Leu Tyr Trp Gly Ala Glu Ile Lys Asn Ser Ala Ile Ser Leu Leu Asp 
                805                 810                 815     


Thr Thr Ala Ile Ala Val Ala Asn Trp Thr Asp Arg Val Ile Glu Leu 
            820                 825                 830         


Gly Gln Gly Ile Gly Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Phe Glu Thr Ala Leu Leu 
    850                 855     


<210> 188
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 188
Met Arg Val Lys Gly Thr Gln Met Asn Leu Gln His Leu Leu Lys Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Leu Ile Ile Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Thr Tyr Asp Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asn Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Asp Gln Met His Ala Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ala Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asp Ser Val Thr Thr Ala Asn Asn Ser Ile Gln Asn Glu 
    130                 135                 140                 


Met Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Val Thr Thr Glu Leu 
145                 150                 155                 160 


Arg Asp Lys Arg Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Ile 
                165                 170                 175     


Val Gln Ile Asp Asn Asn Asn Arg Asn Ser Thr Gln Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Glu Asn Phe Thr Gly Val Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Lys Val Met Ile Arg Ser 
            260                 265                 270         


Glu Asn Ile Ser Asn Asn Ala Lys Asn Ile Leu Val Gln Leu Thr Thr 
        275                 280                 285             


Pro Val Asn Ile Thr Cys Ile Arg Pro Gly Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Val His Ile Ala Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala His Cys Asn Val Asn Arg Thr Gln Trp Asn 
                325                 330                 335     


Asn Thr Leu Lys Glu Val Ala Asn Gln Leu Arg Thr Tyr Phe Gly Asn 
            340                 345                 350         


Glu Thr Ala Ile Ile Phe Ala Ser Ser Ser Gly Gly Asp Leu Glu Ile 
        355                 360                 365             


Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr 
    370                 375                 380                 


Ser Gly Leu Phe His Ser Thr Trp Phe Asn Ser Thr Trp Phe Asn Ser 
385                 390                 395                 400 


Thr Trp Glu Asp Asn Gln Ala Asn Ser Ile Asn Asp Thr Ile Val Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Ala Gly Gln 
            420                 425                 430         


Ala Ile Tyr Ala Pro Pro Ile Pro Gly Glu Ile Arg Cys Glu Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Met Leu Thr Arg Asp Gly Gly Asn Asn Asn Asn Asn 
    450                 455                 460                 


Arg Thr Asn Glu Thr Lys Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp 
465                 470                 475                 480 


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys 
                485                 490                 495     


Ile Glu Pro Leu Gly Leu Ala Pro Thr Gly Ala Lys Arg Arg Val Val 
            500                 505                 510         


Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe 
        515                 520                 525             


Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr 
    530                 535                 540                 


Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn 
545                 550                 555                 560 


Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val 
                565                 570                 575     


Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr 
            580                 585                 590         


Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu 
        595                 600                 605             


Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Ser 
    610                 615                 620                 


Gln Ser Glu Ile Trp Gly Asn Met Thr Trp Gln Gln Trp Glu Lys Glu 
625                 630                 635                 640 


Ile Ser Asn Tyr Thr Glu Glu Ile Tyr Arg Leu Ile Glu Asn Ser Gln 
                645                 650                 655     


Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp 
            660                 665                 670         


Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile 
        675                 680                 685             


Arg Leu Phe Val Ile Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val 
    690                 695                 700                 


Leu Ala Val Phe Ser Ile Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro 
705                 710                 715                 720 


Leu Ser Phe Gln Ile His Thr Pro Asn Pro Gly Gly Leu Asp Arg Pro 
                725                 730                 735     


Gly Arg Ile Glu Glu Glu Asp Gly Glu Gln Gly Lys Ser Arg Ser Ile 
            740                 745                 750         


Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser 
        755                 760                 765             


Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala 
    770                 775                 780                 


Thr Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 


Leu Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Ala Cys Trp 
                805                 810                 815     


Gly Arg Glu Leu Lys Ile Arg Ala Ile Asn Leu Leu Asp Thr Leu Ala 
            820                 825                 830         


Ile Ala Thr Ala Asn Trp Thr Asp Arg Val Ile Glu Leu Leu Gln Ala 
        835                 840                 845             


Leu Gly Arg Ala Phe Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Ala 
    850                 855                 860                 


Glu Arg Ala Trp Leu 
865                 


<210> 189
<211> 859
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 189
Met Lys Ala Arg Gly Met Gln Arg Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Phe Trp Met Ile Ile Met Cys Lys Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Ser Leu Glu Asn Val Thr Glu Lys Phe Asp Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ala Glu Pro Lys Ser Thr Ser Ser Asn Asn Ser Ser Val Asn 
    130                 135                 140                 


Ser Asn Ser Ser Asp Ser Leu Phe Glu Glu Met Lys Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Met Thr Thr Glu Leu Arg Asp Lys Arg Lys Thr Val His Ser Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Ile Val Ser Thr Gly Asn Gly Ser Gly Gln Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Ala Met Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Thr Phe Glu Pro Ile Pro Ile Tyr Tyr Cys Ala Pro Ala Gly Phe 
    210                 215                 220                 


Ala Ile Leu Lys Cys Lys Asp Thr Asn Phe Thr Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu Val Met 
            260                 265                 270         


Ile Arg Ser Glu Asn Ile Thr Asp Asn Ser Lys Ile Ile Ile Val Gln 
        275                 280                 285             


Leu Thr Glu Pro Val Asn Ile Thr Cys Ile Arg Pro Gly Asn Asn Thr 
    290                 295                 300                 


Arg Thr Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly 
305                 310                 315                 320 


Asp Val Ile Gly Asp Ile Arg Lys Ala Tyr Cys Asn Val Ser Arg Ala 
                325                 330                 335     


Ala Trp Asn Ser Thr Leu Gln Lys Ile Ser Thr Gln Leu Arg Arg Tyr 
            340                 345                 350         


Phe Asn Asn Lys Thr Ile Ile Phe Lys Asn Ser Pro Gly Gly Asp Leu 
        355                 360                 365             


Glu Val Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Thr Asp Leu Phe Asn Ser Thr Trp Asp Glu His Gly Thr Val 
385                 390                 395                 400 


Thr Asn Ser Thr Met Ala Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Met Trp Gln Arg Val Gly Gln Ala Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Lys Gly Ser Ile Arg Cys Glu Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Leu Leu Thr Arg Asp Gly Gly Ser Gly Thr Asn Ser Ser Asn Glu Thr 
    450                 455                 460                 


Phe Arg Pro Ile Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu 
465                 470                 475                 480 


Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Ile Gly Leu Ala Arg Thr 
                485                 490                 495     


Arg Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Ile Gly Leu 
            500                 505                 510         


Gly Ala Ala Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
        515                 520                 525             


Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly 
    530                 535                 540                 


Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Lys Ala Gln Gln 
545                 550                 555                 560 


His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 
                565                 570                 575     


Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile 
            580                 585                 590         


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn 
        595                 600                 605             


Ser Asn Trp Ser Asn Lys Ser Gln Ser Glu Ile Trp Asp Asn Met Thr 
    610                 615                 620                 


Trp Met Gln Trp Asp Arg Glu Val Ile Tyr Tyr Thr Asp Ile Ile Tyr 
625                 630                 635                 640 


Asp Leu Ile Glu Lys Ser Gln Asn Pro Gln Glu Lys Asn Glu Gln Asp 
                645                 650                 655     


Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Ser Trp Phe Asp Ile 
            660                 665                 670         


Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val Gly Gly 
        675                 680                 685             


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Ile Asn Arg 
    690                 695                 700                 


Ala Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Leu Thr Pro His 
705                 710                 715                 720 


Pro Glu Gly Pro Asp Arg Pro Gly Arg Ile Lys Glu Glu Gly Gly Glu 
                725                 730                 735     


Gln Gly Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu 
            740                 745                 750         


Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr Arg Arg Leu 
        755                 760                 765             


Arg Asp Phe Ile Ser Ile Thr Ala Arg Thr Val Glu Leu Leu Gly Arg 
    770                 775                 780                 


Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu 
785                 790                 795                 800 


Gly Asn Leu Leu Gly Tyr Trp Gly Gln Glu Leu Lys Ser Ser Ala Ile 
                805                 810                 815     


Asn Leu Ile Asp Thr Ile Ala Ile Ala Val Ala Gly Trp Thr Asp Arg 
            820                 825                 830         


Val Ile Glu Ile Gly Gln Arg Phe Cys Arg Ala Ile Arg Asn Ile Pro 
        835                 840                 845             


Arg Ile Arg Gln Gly Ala Glu Lys Ala Leu Gln 
    850                 855                 


<210> 190
<211> 837
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 190
Met Lys Val Arg Gly Ile Lys Arg Asn Leu Trp Lys Trp Gly Thr Met 
1               5                   10                  15      


Leu Leu Gly Met Leu Met Thr Tyr Ser Val Ala Glu Gln Leu Trp Val 
            20                  25                  30          


Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu Thr Thr Leu 
        35                  40                  45              


Phe Cys Ala Ser Asp Ala Lys Ala Tyr Ser Thr Glu Lys His Asn Ile 
    50                  55                  60                  


Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile 
65                  70                  75                  80  


His Leu Glu Ser Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met 
                85                  90                  95      


Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu 
            100                 105                 110         


Arg Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr 
        115                 120                 125             


Asn Val Asn Asn Asn Thr Thr Asn Val Asn Asn Asn Thr Gly Trp Asp 
    130                 135                 140                 


Glu Glu Arg Lys Asn Cys Ser Phe Asn Val Thr Thr Glu Leu Arg Asp 
145                 150                 155                 160 


Lys Arg Gln Lys Val Tyr Ser Leu Phe Tyr Lys Leu Asp Val Val Gln 
                165                 170                 175     


Ile Asp Asn Ser Ser Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile 
            180                 185                 190         


Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr 
        195                 200                 205             


Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Glu Lys Phe 
    210                 215                 220                 


Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His 
225                 230                 235                 240 


Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
                245                 250                 255     


Ala Glu Lys Glu Val Met Ile Arg Ser Glu Asn Phe Thr Asn Ser Ala 
            260                 265                 270         


Lys Asn Ile Leu Val Gln Phe Lys Glu Pro Val Lys Ile Asn Cys Thr 
        275                 280                 285             


Arg Pro Asp Asn Asn Thr Arg Thr Ser Ile Arg Ile Gly Pro Gly Gln 
    290                 295                 300                 


Ala Phe Tyr Ala Thr Gly Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys 
305                 310                 315                 320 


Thr Val Asn Gly Ser Glu Trp Asn Lys Ala Leu Gln Lys Val Val Glu 
                325                 330                 335     


Gln Leu Arg Ser Ser Phe Glu Asn Lys Thr Ile Ile Phe Ala Asn Ser 
            340                 345                 350         


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
        355                 360                 365             


Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asp Ser Thr Trp Asn 
    370                 375                 380                 


Asp Thr Asp Ser Arg Gln Glu Asn Gly Thr Ile Thr Leu Pro Cys Arg 
385                 390                 395                 400 


Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Thr Gly Gln Ala Ile Tyr 
                405                 410                 415     


Ala Pro Pro Ile Gln Gly Ala Ile Arg Cys Val Ser Asn Ile Thr Gly 
            420                 425                 430         


Leu Ile Leu Thr Arg Asp Gly Gly Asn Asn Asn Ser Thr Asn Glu Thr 
        435                 440                 445             


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
    450                 455                 460                 


Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr 
465                 470                 475                 480 


Lys Ala Arg Arg Arg Val Val Gly Arg Glu Lys Arg Ala Val Gly Ile 
                485                 490                 495     


Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
            500                 505                 510         


Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly 
        515                 520                 525             


Ile Val Gln Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln 
    530                 535                 540                 


His Leu Leu Arg Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 
545                 550                 555                 560 


Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile 
                565                 570                 575     


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn 
            580                 585                 590         


Ser Ser Trp Ser Asn Lys Ser Gln Ser Glu Ile Trp Glu Asn Met Thr 
        595                 600                 605             


Trp Leu Gln Trp Glu Lys Glu Ile Ser Asn Tyr Thr Gln Ile Ile Tyr 
    610                 615                 620                 


Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp 
625                 630                 635                 640 


Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
                645                 650                 655     


Ser Lys Trp Leu Trp His Ile Arg Ile Phe Ile Met Ile Val Gly Gly 
            660                 665                 670         


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Val Val Asn Arg 
        675                 680                 685             


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Leu Pro Ala 
    690                 695                 700                 


Pro Arg Gly Pro Asp Arg Pro Asp Gly Ile Glu Glu Glu Gly Gly Glu 
705                 710                 715                 720 


Gln Gly Arg Gly Arg Ser Arg Gln Leu Val Asn Gly Phe Ser Thr Leu 
                725                 730                 735     


Ile Trp Asp Asp Leu Arg Asn Leu Cys Leu Phe Ser Tyr His Arg Leu 
            740                 745                 750         


Arg Asp Leu Ile Leu Ile Ala Ala Arg Ile Val Glu Leu Leu Gly Arg 
        755                 760                 765             


Arg Gly Trp Glu Ala Ile Lys Tyr Leu Trp Asn Leu Leu Gln Tyr Trp 
    770                 775                 780                 


Ile Gln Glu Leu Lys Asn Ser Ala Ile Ser Leu Leu Asn Thr Thr Ala 
785                 790                 795                 800 


Ile Ala Val Ala Glu Gly Thr Asp Arg Ala Ile Glu Ile Ile Gln Arg 
                805                 810                 815     


Ala Ile Thr Ala Val Leu Asn Ile Pro Thr Arg Ile Arg Gln Gly Phe 
            820                 825                 830         


Glu Arg Ala Leu Leu 
        835         


<210> 191
<211> 866
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 191
Thr Arg Val Met Gly Ile Gln Arg Asn Cys Thr Pro Trp Trp Arg Trp 
1               5                   10                  15      


Gly Ile Ile Phe Leu Gly Leu Ile Ile Ile Cys Lys Ala Thr Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asp Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys His Asn Val Thr Lys Thr Asn Ser Asn Ser Asn Ser Ser Val 
    130                 135                 140                 


Lys Asn Glu Met Pro Gly Glu Ile Lys Asn Cys Ser Tyr Asn Val Thr 
145                 150                 155                 160 


Thr Ala Ile Arg Asp Lys Arg Gln Asn Val Tyr Ser Leu Phe Tyr Arg 
                165                 170                 175     


Val Asp Val Val Pro Ile Asn Glu Asn Ser Asn Ser Ser Glu Asn Ser 
            180                 185                 190         


Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala 
        195                 200                 205             


Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro 
    210                 215                 220                 


Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Asp Phe Asn Gly Thr 
225                 230                 235                 240 


Gly Thr Cys Arg Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys 
                245                 250                 255     


Pro Val Val Thr Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly 
            260                 265                 270         


Lys Val Met Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile 
        275                 280                 285             


Ile Val Gln Leu Asp Glu Pro Val Tyr Ile Asn Cys Thr Arg Pro Asn 
    290                 295                 300                 


Asn Asn Thr Arg Lys Ser Val His Ile Gly Pro Gly Gln Ala Phe Tyr 
305                 310                 315                 320 


Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Val 
                325                 330                 335     


Ser Arg Glu Asp Trp Asn Lys Thr Leu Tyr Lys Val Val Glu Gln Leu 
            340                 345                 350         


Arg Lys His Phe Asn Asn Arg Thr Ile Asn Phe Thr Ala Pro Ser Gly 
        355                 360                 365             


Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe 
    370                 375                 380                 


Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Tyr Asn Ser 
385                 390                 395                 400 


Thr Trp Asn Asn Thr Asp Ser Thr Gln Lys Ser Asn Gly Thr Glu Lys 
                405                 410                 415     


Ile Thr Leu Pro Cys Arg Ile Lys Gln Val Ile Lys Met Trp Gln Arg 
            420                 425                 430         


Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Lys Cys 
        435                 440                 445             


Val Ser Asn Ile Thr Gly Ile Leu Leu Thr Arg Asp Gly Gly Asn Leu 
    450                 455                 460                 


Asn Ser Ser Phe Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp 
465                 470                 475                 480 


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro 
                485                 490                 495     


Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu 
            500                 505                 510         


Lys Arg Ala Val Gly Leu Gly Ala Val Phe Leu Gly Phe Leu Gly Ala 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Ala Gln Ala 
    530                 535                 540                 


Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Ile Glu Ala Gln Gln Gln Met Leu Lys Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr 
        595                 600                 605             


Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Tyr Ser Glu 
    610                 615                 620                 


Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn 
625                 630                 635                 640 


Tyr Thr Asp Leu Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu 
            660                 665                 670         


Trp Asn Trp Phe Asn Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe 
        675                 680                 685             


Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Thr Val 
    690                 695                 700                 


Leu Ser Ile Ile Asn Arg Val Arg Lys Gly Tyr Ser Pro Leu Ser Phe 
705                 710                 715                 720 


Gln Thr His Ser Pro Ser Pro Gly Gly Leu Asp Arg Pro Arg Gly Ile 
                725                 730                 735     


Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu Val 
            740                 745                 750         


Ser Gly Phe Leu Ala Leu Ala Trp Asn Asp Leu Arg Ser Leu Cys Leu 
        755                 760                 765             


Phe Ser Tyr His Arg Leu Arg Asp Phe Thr Leu Ile Ala Ala Arg Thr 
    770                 775                 780                 


Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp 
785                 790                 795                 800 


Glu Gly Leu Gln Tyr Leu Gly Asn Leu Leu Leu Tyr Trp Gly Arg Glu 
                805                 810                 815     


Leu Lys Asn Ser Ala Ile Ser Leu Leu Asp Ala Ile Ala Ile Thr Val 
            820                 825                 830         


Ala Gly Trp Thr Asp Arg Val Ile Glu Val Gly Gln Arg Ala Gly Arg 
        835                 840                 845             


Ala Leu Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala 
    850                 855                 860                 


Leu Leu 
865     


<210> 192
<211> 860
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 192
Met Arg Ala Arg Gly Thr Gln Lys Asn Cys Gln Asp Leu Trp Trp Ile 
1               5                   10                  15      


Trp Gly Thr Met Ile Leu Gly Met Leu Ile Ile Cys Ser Ala Ala Gly 
            20                  25                  30          


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala 
        35                  40                  45              


Glu Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Ser Thr Glu 
    50                  55                  60                  


Lys His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Ile Asp Leu Glu Asn Val Thr Glu Lys Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Gly Met Val Glu Gln Met His Thr Asp Ile Ile Ser Ile Trp 
            100                 105                 110         


Asp Gln Ser Leu Gln Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
        115                 120                 125             


Leu Ile Cys Ile Asp Ile Ala Asn Asp Thr Ser Arg Asn Val Thr Val 
    130                 135                 140                 


Glu Met Lys Arg Glu Ile Gln Asn Cys Ser Tyr Asn Val Thr Thr Glu 
145                 150                 155                 160 


Val Arg Asp Lys Lys Gln Lys Val Tyr Ser Leu Phe Tyr Lys Val Asp 
                165                 170                 175     


Ile Val Gln Ile Ser Asn Asn Ser Ser Glu Tyr Arg Leu Ile Asn Cys 
            180                 185                 190         


Asn Thr Ser Val Ile Lys Gln Ala Cys Pro Lys Val Thr Phe Glu Pro 
        195                 200                 205             


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys 
    210                 215                 220                 


Lys Asp Asp Lys Phe Asn Gly Thr Gly Leu Cys Lys Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Ile Ile Arg Ser Glu Asn 
            260                 265                 270         


Ile Asn Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Tyr Gln Pro Val 
        275                 280                 285             


Lys Ile Asn Cys Thr Arg Pro Gly Asn Asn Thr Arg Lys Ser Val His 
    290                 295                 300                 


Ile Gly Thr Gly Gln Ala Tyr Phe Ala Thr Gly Asp Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Gln Ala Tyr Cys Lys Val Asn Lys Ser Glu Trp Asn Asn Thr 
                325                 330                 335     


Leu Gln Gln Val Val Ala Gln Leu Arg Lys His Trp Asn Lys Thr Ile 
            340                 345                 350         


Ile Phe Asn Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Arg 
        355                 360                 365             


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Ser Leu Phe 
    370                 375                 380                 


Asn Ser Thr Trp Trp Ser Asn Asn Ser Asn Asn Thr Asp Ser Glu Glu 
385                 390                 395                 400 


Ser Asn Ser Met Gly Leu Asn Asp Thr Ile Thr Leu Gln Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Met Trp Gln Arg Val Gly Gln Ala Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Gln Gly Val Ile Arg Cys Glu Ser Asn Ile Thr Gly Ile 
        435                 440                 445             


Leu Leu Thr Arg Asp Gly Gly Asp Asn Asn Asn Glu Ser Glu Thr Phe 
    450                 455                 460                 


Arg Pro Val Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
465                 470                 475                 480 


Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Glu 
                485                 490                 495     


Ala Arg Arg Arg Val Val Gly Arg Gly Lys Arg Ala Val Val Gly Met 
            500                 505                 510         


Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
        515                 520                 525             


Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly 
    530                 535                 540                 


Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 
545                 550                 555                 560 


His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 
                565                 570                 575     


Ile Leu Ala Val Glu Asn Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile 
            580                 585                 590         


Trp Gly Cys Ser Gly Arg Leu Ile Cys Thr Thr Asn Val Lys Trp Asn 
        595                 600                 605             


Ser Thr Trp Ser Asn Lys Ser Lys Ser Glu Ile Trp Asp Lys Met Thr 
    610                 615                 620                 


Trp Leu Glu Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp Ile Ile Tyr 
625                 630                 635                 640 


Gln Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp 
                645                 650                 655     


Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Asn Trp Phe Asp Ile 
            660                 665                 670         


Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly 
        675                 680                 685             


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Val Ile Asn Arg 
    690                 695                 700                 


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Thr Pro Ser 
705                 710                 715                 720 


Pro Arg Asp Leu Asp Arg Pro Gly Arg Ile Glu Glu Glu Gly Gly Glu 
                725                 730                 735     


Gln Gly Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu 
            740                 745                 750         


Ala Trp Asp Asp Leu Arg Ser Leu Cys Ile Phe Ser Tyr His Arg Leu 
        755                 760                 765             


Arg Asp Leu Leu Leu Ile Ala Ala Arg Thr Val Glu Leu Leu Gly Gln 
    770                 775                 780                 


Ser Ser Leu Lys Gly Leu Arg Leu Gly Arg Glu Lys Leu Lys Tyr Leu 
785                 790                 795                 800 


Gly Asn Leu Leu Leu Tyr Trp Gly Arg Glu Leu Arg Ile Ser Ile Ile 
                805                 810                 815     


Asn Leu Tyr Asp Thr Ile Ala Ile Ala Val Ala Gly Trp Thr Asp Arg 
            820                 825                 830         


Ile Ile Glu Ile Gly Gln Arg Ile Gly Arg Ala Ile Leu Asn Ile Pro 
        835                 840                 845             


Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
    850                 855                 860 


<210> 193
<211> 845
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 193
Met Arg Val Met Gly Ile Gln Lys Asn Tyr Ala Leu Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Ile Ile Phe Trp Ile Met Ile Ile Cys Asn Ala Asp Asn Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Gln Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asp Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Asn Asn Ile Thr Gly Asn Ala Thr Tyr Asp Met Gln Arg Glu 
    130                 135                 140                 


Ile Ser Asn Cys Ser Phe Asn Ile Thr Thr Glu Ile Arg Asp Lys Lys 
145                 150                 155                 160 


Gln Lys Val Asn Ser Leu Phe Tyr Arg Leu Asp Ile Val Pro Ile Gly 
                165                 170                 175     


Asp Asn Lys Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala 
            180                 185                 190         


Leu Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Lys 
    210                 215                 220                 


Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Leu Ala Glu Glu Gly Val Met Ile Arg Ser Glu Asn Phe Thr Asn Asn 
            260                 265                 270         


Ala Lys Thr Ile Ile Val Gln Leu Gln Glu Pro Val Lys Ile Asn Cys 
        275                 280                 285             


Thr Arg Pro Asn Asn Asn Thr Arg Lys Gly Val His Ile Gly Pro Gly 
    290                 295                 300                 


Gln Ala Phe Tyr Ala Thr Gly Gly Ile Ile Gly Asn Ile Ser Lys Ala 
305                 310                 315                 320 


Arg Gln Tyr Val Asn Thr Thr Glu Trp Ile Lys Ala Leu Lys Glu Val 
                325                 330                 335     


Asn Lys Thr Leu Asn Gln Gln Phe Val Asn Lys Thr Leu Tyr Phe Asn 
            340                 345                 350         


Glu Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Asp Leu Phe Asn Ser Thr 
    370                 375                 380                 


Trp Leu Asn Ser Thr Val Glu Ser Asn Glu Thr Ile Ile Leu Pro Cys 
385                 390                 395                 400 


Lys Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Val Gly Gln Ala Met 
                405                 410                 415     


Tyr Ala Pro Pro Ile Gln Gly Val Ile Asn Cys Val Ser Asn Ile Thr 
            420                 425                 430         


Gly Ile Leu Leu Val Arg Asp Gly Gly Asn Asn Asn Ser Thr Ala Glu 
        435                 440                 445             


Thr Phe Arg Pro Gly Gly Gly Asp Met Lys Asp Asn Trp Arg Ser Glu 
    450                 455                 460                 


Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro 
465                 470                 475                 480 


Thr Arg Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly 
                485                 490                 495     


Leu Gly Ala Val Phe Phe Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
            500                 505                 510         


Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
        515                 520                 525             


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln 
    530                 535                 540                 


Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
545                 550                 555                 560 


Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
                565                 570                 575     


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp 
            580                 585                 590         


Asn Ser Ser Trp Ser Asn Lys Ser Gln Asp Glu Ile Trp Asp Asn Met 
        595                 600                 605             


Thr Trp Leu Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Ser Thr Ile 
    610                 615                 620                 


Tyr Asn Leu Leu Glu Glu Ala Gln Asn Gln Gln Glu Lys Asn Glu Gln 
625                 630                 635                 640 


Asp Leu Leu Ala Leu Asp Gln Trp Ala Ser Leu Trp Asn Trp Phe Asn 
                645                 650                 655     


Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly 
            660                 665                 670         


Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Thr Leu Ile Asn 
        675                 680                 685             


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr His 
    690                 695                 700                 


His Gln Arg Glu Pro Asp Arg Pro Glu Arg Ile Glu Glu Gly Gly Gly 
705                 710                 715                 720 


Glu Gln Asp Arg Asp Arg Ser Val Arg Leu Val Ser Gly Phe Leu Ala 
                725                 730                 735     


Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg 
            740                 745                 750         


Leu Arg Asp Phe Val Leu Ile Val Val Arg Thr Val Glu Leu Leu Gly 
        755                 760                 765             


His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Ala Leu Lys Tyr 
    770                 775                 780                 


Leu Gly Asn Leu Leu Ser Tyr Trp Gly Gln Glu Ile Lys Asn Ser Ala 
785                 790                 795                 800 


Ile Asn Leu Leu Asn Thr Thr Ala Ile Ala Val Ala Asn Trp Thr Asp 
                805                 810                 815     


Arg Val Ile Glu Val Gly Gln Arg Ala Gly Arg Ala Leu Leu His Ile 
            820                 825                 830         


Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
        835                 840                 845 


<210> 194
<211> 878
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 194
Met Arg Val Lys Gly Ile Gln Arg Asn Ser Gln His Leu Leu Arg Trp 
1               5                   10                  15      


Gly Thr Ile Ile Leu Gly Leu Ile Ile Ile Ser Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp 
        35                  40                  45              


Thr Ser Leu Phe Cys Ala Ser Asp Ala Lys Thr Tyr Lys Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Tyr Leu Lys Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Ala Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Gln Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asp Cys Ser Tyr Asn Val Thr Val Arg Pro Asn Asn Thr Ala Val Asn 
    130                 135                 140                 


Tyr Thr Thr Phe Met Lys Glu Glu Met Lys Asn Cys Ser Tyr Asn Met 
145                 150                 155                 160 


Thr Thr Glu Ile Arg Asp Lys Lys Lys Lys Val Tyr Ser Leu Phe Tyr 
                165                 170                 175     


Arg Leu Asp Val Val Gln Ile Asp Glu Ile Asp Glu Asn Asn Ser Asn 
            180                 185                 190         


Asn Ser Asn Asn Thr Asn Asn Ser Leu Tyr Arg Leu Ile Asn Cys Asn 
        195                 200                 205             


Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile 
    210                 215                 220                 


Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Arg 
225                 230                 235                 240 


Asp Lys Asn Phe Asn Gly Thr Gly Pro Cys Arg Asn Val Ser Ser Ala 
                245                 250                 255     


Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu 
            260                 265                 270         


Asn Gly Ser Leu Ala Glu Gly Lys Glu Val Met Ile Arg Ser Glu Asn 
        275                 280                 285             


Ile Thr Ser Asn Thr Lys Asn Ile Ile Val Gln Leu Thr Lys Pro Val 
    290                 295                 300                 


Gln Ile Asn Cys Thr Arg Pro Ser Asn Asn Thr Arg Thr Ser Val His 
305                 310                 315                 320 


Ile Gly Pro Gly Gln Ala Phe Tyr Thr Thr Gly Glu Ile Ile Gly Asp 
                325                 330                 335     


Ile Arg Arg Ala His Cys Asn Val Ser Lys Ala Lys Trp Asn Glu Thr 
            340                 345                 350         


Leu Gly Lys Ile Ala Ile Gln Leu Glu Lys His Phe Lys Asn Lys Thr 
        355                 360                 365             


Ile Lys Phe Asn Pro Ser Ser Gly Gly Asp Met Glu Ile Thr Thr His 
    370                 375                 380                 


Met Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Asn Leu 
385                 390                 395                 400 


Phe Asn Ser Asn Trp Thr Ile Trp Asn Gly Ser Ala Ile Ser Asn Gly 
                405                 410                 415     


Ser Ala Thr Ala Asn Thr Glu Ser Asn Asp Thr Val Ile Thr Leu Gln 
            420                 425                 430         


Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Ala Gly Gln Ala 
        435                 440                 445             


Ile Tyr Ala Pro Pro Ile Lys Gly Val Ile Lys Cys Asn Ser Asn Ile 
    450                 455                 460                 


Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asp Asn Asn Ser Asn Ile 
465                 470                 475                 480 


Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser 
                485                 490                 495     


Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala 
            500                 505                 510         


Pro Thr Arg Ala Arg Arg Arg Val Val Gln Arg Glu Lys Arg Ala Ala 
        515                 520                 525             


Gly Leu Gly Ala Val Phe Ile Gly Phe Leu Gly Ala Ala Gly Ser Thr 
    530                 535                 540                 


Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
545                 550                 555                 560 


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala 
                565                 570                 575     


Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
            580                 585                 590         


Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
        595                 600                 605             


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro 
    610                 615                 620                 


Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Asn Glu Ile Trp Asp Asn 
625                 630                 635                 640 


Met Thr Trp Leu Glu Trp Asp Lys Glu Ile Ser Asn Tyr Thr Arg Ile 
                645                 650                 655     


Ile Tyr Asp Leu Ile Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu 
            660                 665                 670         


Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
        675                 680                 685             


Asp Ile Ser Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val 
    690                 695                 700                 


Gly Gly Leu Ile Gly Leu Arg Ile Val Cys Thr Val Leu Ser Val Ile 
705                 710                 715                 720 


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Ala 
                725                 730                 735     


Pro Ser Pro Gly Asp Arg Asp Arg Pro Gly Arg Ile Glu Glu Glu Gly 
            740                 745                 750         


Gly Glu Gln Gly Arg Gly Arg Ser Ile Arg Leu Val Ser Gly Phe Leu 
        755                 760                 765             


Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
    770                 775                 780                 


Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu 
785                 790                 795                 800 


Gly His Asn Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys 
                805                 810                 815     


Tyr Leu Trp Asn Leu Leu Ala Tyr Trp Gly Arg Glu Leu Lys Ile Ser 
            820                 825                 830         


Ala Ile Asn Leu Leu Asn Thr Ile Ala Ile Ala Val Ala Gly Trp Thr 
        835                 840                 845             


Asp Arg Val Ile Glu Ile Gly Gln Arg Leu Cys Arg Ala Phe Ile Asn 
    850                 855                 860                 


Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
865                 870                 875             


<210> 195
<211> 844
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 195
Met Arg Val Met Gly Ile Gln Arg Asn Tyr Leu Pro Leu Trp Arg Trp 
1               5                   10                  15      


Gly Met Ile Phe Leu Gly Met Met Ile Ile Cys Lys Ala Thr Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Gln Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Leu Asp Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Ile Asn Ser Thr Arg Tyr Asp Thr Lys Asp Lys Glu 
    130                 135                 140                 


Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Leu Arg Asp Lys 
145                 150                 155                 160 


Arg Gln Ser Val Tyr Ser Leu Phe Tyr Lys Leu Asp Val Val Pro Ile 
                165                 170                 175     


Asn Asn Asn Ser Ser Asn Asn Ser Ser Asn Glu Tyr Arg Leu Ile Asn 
            180                 185                 190         


Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu 
        195                 200                 205             


Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys 
    210                 215                 220                 


Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Arg Asn Val Ser 
225                 230                 235                 240 


Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu 
                245                 250                 255     


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Met Ile Arg Ser Glu 
            260                 265                 270         


Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Val Thr Pro 
        275                 280                 285             


Val Gln Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Thr Ser Val 
    290                 295                 300                 


Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly 
305                 310                 315                 320 


Lys Ile Arg Gln Ala His Cys Thr Val Arg Arg Ala Gln Trp Asn Thr 
                325                 330                 335     


Thr Leu Gln Gln Val Ala Asp Gln Leu Arg Lys His Phe Asn Lys Thr 
            340                 345                 350         


Ile Asn Phe Thr Arg Pro Ser Gly Gly Asp Leu Glu Ile Thr Thr His 
        355                 360                 365             


Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu 
    370                 375                 380                 


Phe Asn Ser Thr Trp Asn Ser Thr Thr Ile Lys Gln Asn Leu Thr Asn 
385                 390                 395                 400 


Asn Asp Thr Gly Val Ile Asn Leu Pro Cys Arg Ile Arg Gln Ile Val 
                405                 410                 415     


His Met Trp Gln Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Lys 
            420                 425                 430         


Gly Val Ile Asn Cys Thr Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Asp Asn Asn Ser Thr Asp Glu Lys Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
465                 470                 475                 480 


Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Arg Arg 
                485                 490                 495     


Val Val Gln Arg Glu Lys Arg Ala Val Gly Leu Gly Ala Val Phe Phe 
            500                 505                 510         


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr 
        515                 520                 525             


Leu Thr Ala Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
    530                 535                 540                 


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu 
545                 550                 555                 560 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu 
                565                 570                 575     


Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly 
            580                 585                 590         


Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn 
        595                 600                 605             


Lys Ser Gln Asn Glu Ile Trp Glu Asn Met Thr Trp Leu Gln Trp Asp 
    610                 615                 620                 


Lys Glu Ile Ser Asn Tyr Thr Asp Ile Ile Tyr Asn Leu Ile Glu Glu 
625                 630                 635                 640 


Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp 
                645                 650                 655     


Lys Trp Ala Asn Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp 
            660                 665                 670         


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
        675                 680                 685             


Ile Val Phe Ala Val Leu Ser Ile Ile Asn Arg Val Arg Gln Gly Tyr 
    690                 695                 700                 


Ser Pro Leu Ser Phe Gln Thr His Thr Pro Asn Pro Gly Gly Leu Asp 
705                 710                 715                 720 


Arg Pro Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg 
                725                 730                 735     


Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Val Trp Asp Asp Leu 
            740                 745                 750         


Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Thr Leu 
        755                 760                 765             


Ile Ala Ala Arg Thr Val Glu Leu Leu Gly Gln Gly Leu Lys Tyr Leu 
    770                 775                 780                 


Trp Asn Leu Leu Leu Tyr Trp Gly Arg Glu Leu Lys Ser Ser Ala Ile 
785                 790                 795                 800 


Ser Leu Leu Asn Ala Thr Ala Ile Val Val Ala Glu Trp Thr Asp Arg 
                805                 810                 815     


Val Ile Glu Val Gly Gln Arg Ala Gly Arg Ala Leu Leu His Ile Pro 
            820                 825                 830         


Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
        835                 840                 


<210> 196
<211> 857
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 196
Met Arg Val Met Gly Thr Gln Arg Asn Trp Gln Pro Leu Leu Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Leu Met Ile Cys Ser Ala Ala Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Ile Pro Leu Lys Asn Val Thr Glu Lys Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Gln Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asp Val Thr Thr Asn Asn Thr Lys Val Asn Thr Thr Ser 
    130                 135                 140                 


Ala Pro Thr Thr Thr Ala Thr Val Asn Asn Asp Asn Asp Met Lys Asn 
145                 150                 155                 160 


Cys Ser Tyr Asn Ile Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Arg 
                165                 170                 175     


Tyr Ser Leu Phe Tyr Arg Leu Asp Val Glu Leu Ile Asn Lys Asn Asn 
            180                 185                 190         


Ser Asn Ser Thr Glu Tyr Val Leu Ile Asn Cys Lys Thr Ser Thr Leu 
        195                 200                 205             


Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Lys His Tyr 
    210                 215                 220                 


Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Glu Phe 
225                 230                 235                 240 


Asn Gly Thr Gly Leu Cys Lys Asn Val Ser Thr Val Gln Cys Thr His 
                245                 250                 255     


Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
            260                 265                 270         


Val Glu Lys Arg Val Met Ile Arg Ser Ala Asn Ile Thr Asp Asn Thr 
        275                 280                 285             


Lys Asn Ile Ile Val Gln Leu Lys Glu Pro Val Glu Ile Asn Cys Thr 
    290                 295                 300                 


Arg Pro Asn Asn Asn Thr Arg Lys Gly Val His Ile Gly Leu Gly Arg 
305                 310                 315                 320 


Arg Phe Tyr Thr Thr Gln Val Val Gly Asp Ile Arg Gln Ala Tyr Cys 
                325                 330                 335     


Asn Val Ser Lys Ser Lys Trp Asn Asp Thr Leu Lys Lys Val Val Tyr 
            340                 345                 350         


Gln Leu Arg Lys Tyr Phe Asn Lys Thr Ile Ile Phe Asn Ser Ser Ser 
        355                 360                 365             


Gly Gly Asp Val Glu Ile Thr Thr His Met Phe Thr Cys Gly Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Pro Val 
385                 390                 395                 400 


Asn Ala Ser Glu Gln Glu Ser Asn Ser Thr Glu Ser Asp Gly Ile Ile 
                405                 410                 415     


Thr Leu Arg Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Thr 
            420                 425                 430         


Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Ile Ile Lys Cys Val 
        435                 440                 445             


Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Thr 
    450                 455                 460                 


Val Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly 
                485                 490                 495     


Val Ala Pro Thr Lys Ala Arg Arg Arg Val Val Gly Arg Glu Lys Arg 
            500                 505                 510         


Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly 
        515                 520                 525             


Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln 
    530                 535                 540                 


Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile 
545                 550                 555                 560 


Glu Ala Gln Gln Gln Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln 
                565                 570                 575     


Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln 
            580                 585                 590         


Leu Leu Gly Ile Trp Gly Cys Ser Glu Lys Leu Ile Cys Thr Thr Asn 
        595                 600                 605             


Ala Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Ser Glu Ile Trp 
    610                 615                 620                 


Asp Asn Met Thr Trp Leu Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr 
625                 630                 635                 640 


Asp Ile Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys 
                645                 650                 655     


Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ser Ser Leu Trp Thr 
            660                 665                 670         


Trp Phe Asp Leu Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met 
        675                 680                 685             


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ala 
    690                 695                 700                 


Val Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
705                 710                 715                 720 


Leu Thr Pro Asn Pro Gly Glu Leu Asp Arg Pro Gly Arg Ile Glu Gly 
                725                 730                 735     


Glu Gly Gly Glu Gln Asp Arg Gly Arg Ser Ile Arg Leu Val Ser Gly 
            740                 745                 750         


Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser 
        755                 760                 765             


Tyr His His Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Ile Val Gly 
    770                 775                 780                 


Leu Leu Gly Arg Arg Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu 
785                 790                 795                 800 


Leu Ile Tyr Trp Gly Gln Glu Leu Lys Thr Ser Ala Val Ser Leu Leu 
                805                 810                 815     


Asp Thr Ile Ala Ile Val Val Ala Gly Trp Thr Asp Arg Val Leu Glu 
            820                 825                 830         


Ile Gly Gln Arg Ile Gly Arg Ala Phe Ile Asn Ile Pro Arg Arg Ile 
        835                 840                 845             


Arg Gln Gly Phe Glu Arg Ala Leu Leu 
    850                 855         


<210> 197
<211> 855
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 197
Met Arg Val Met Gly Ile Gln Arg Asn Tyr Pro Cys Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Leu Ile Ile Ile Cys Asn Ala Gln Gln Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Val Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Ala Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Ile Asp Leu Val Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asp 
        115                 120                 125             


Cys His Asn Ile Thr Ile Asn Asn Thr Asn Asn Asn Thr Asn Ile Thr 
    130                 135                 140                 


Asp Gly Val Arg Glu Glu Met Lys Asn Cys Ser Phe Asn Met Thr Thr 
145                 150                 155                 160 


Glu Leu Arg Asp Lys Lys Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu 
                165                 170                 175     


Asp Ile Val Gln Ile Asn Lys Thr Asp Asn Asn Ser Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Pro Glu Phe Asn Gly Lys Gly Pro Cys Arg Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Arg Glu Ile Arg Ile Arg Ser 
            260                 265                 270         


Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Val Asn 
        275                 280                 285             


Pro Val Lys Ile Asn Cys Ser Arg Pro Tyr Asn Thr Arg Lys Asn Ile 
    290                 295                 300                 


Arg Arg Tyr Ser Ile Gly Ser Gly Gln Ala Phe Tyr Val Thr Gly Lys 
305                 310                 315                 320 


Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Val Ser Arg Arg Asp 
                325                 330                 335     


Trp Asn Arg Thr Ile Gln Gln Val Ala Glu Gln Leu Lys Lys Lys Phe 
            340                 345                 350         


Asn Asn Lys Thr Ile Ile Phe Ala Ser Ser Ser Gly Gly Asp Ile Glu 
        355                 360                 365             


Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Ser Gly Leu Phe Asn Ser Ile Trp Asn Gly Ser Met Ser Asn Asp 
385                 390                 395                 400 


Met Gly Pro Asn Gly Thr Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile 
                405                 410                 415     


Ile Asn Met Trp Gln Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile 
            420                 425                 430         


Gln Gly Val Ile Arg Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu Thr 
        435                 440                 445             


Arg Asp Gly Gly Thr Asn Asn Thr Lys Asn Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asp Met Arg Asp Asn Trp Lys Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Arg 
                485                 490                 495     


Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Leu Gly Ala Ile Phe 
            500                 505                 510         


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile 
        515                 520                 525             


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
    530                 535                 540                 


Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys 
545                 550                 555                 560 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
                565                 570                 575     


Glu Arg Tyr Leu Gln Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
            580                 585                 590         


Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp Ser 
        595                 600                 605             


Asn Lys Ser Gln Glu Asp Ile Trp Asn Asn Met Thr Trp Leu Gln Trp 
    610                 615                 620                 


Glu Lys Glu Ile Ser Ser Tyr Thr Gly Ile Ile Tyr Gln Leu Ile Glu 
625                 630                 635                 640 


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Leu Asp Leu Leu Ala Leu 
                645                 650                 655     


Asp Lys Trp Ala Asn Leu Asn Trp Phe Asn Ile Ser Asn Trp Leu Trp 
            660                 665                 670         


Tyr Ile Arg Leu Phe Val Ile Ile Val Gly Gly Leu Ile Gly Leu Arg 
        675                 680                 685             


Ile Val Phe Thr Val Leu Ser Ile Ile Asn Arg Val Arg Gln Gly Tyr 
    690                 695                 700                 


Ser Pro Leu Ser Phe Gln Thr Leu Ala Pro Ile Pro Glu Gly Leu Gly 
705                 710                 715                 720 


Arg Pro Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Gly Lys Asp Arg 
                725                 730                 735     


Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Ile Ala Trp Asp Asp Leu 
            740                 745                 750         


Arg Asn Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ala Leu 
        755                 760                 765             


Ile Val Ala Arg Ala Val Glu Leu Leu Gly Arg Ser Ser Leu Lys Gly 
    770                 775                 780                 


Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Leu 
785                 790                 795                 800 


Tyr Trp Gly Arg Glu Leu Lys Ile Ser Ala Ile Thr Leu Leu Asp Ala 
                805                 810                 815     


Val Ala Val Ala Val Ala Gly Trp Ile Asp Arg Val Ile Glu Ile Gly 
            820                 825                 830         


Gln Thr Ile Gly Arg Ala Ile Leu Asn Ile Pro Arg Arg Ile Arg Gln 
        835                 840                 845             


Gly Leu Glu Arg Ala Leu Leu 
    850                 855 


<210> 198
<211> 860
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 198
Met Arg Val Met Gly Thr Gln Arg Asn Cys Gln His Leu Leu Asn Trp 
1               5                   10                  15      


Gly Ile Met Ile Leu Gly Met Ile Ile Ile Cys Ser Thr Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Leu Tyr Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Gln Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Asn Val Thr Ala Asn Thr Asn Ser Thr Ser Ala Asn 
    130                 135                 140                 


Leu Thr Asp Ser Val Lys Gly Glu Met Arg Asn Cys Ser Phe Asn Ile 
145                 150                 155                 160 


Thr Thr Glu Leu Arg Asp Lys Lys Lys Lys Val Tyr Ser Leu Phe Tyr 
                165                 170                 175     


Lys Leu Asp Ile Val Lys Ile Asn Lys Asn Lys Ser Phe Arg Gly Lys 
            180                 185                 190         


Asn Ser Ser Gly Asn Ser Ser Ser Asp Arg Tyr Arg Leu Ile Asn Cys 
        195                 200                 205             


Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro 
    210                 215                 220                 


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
225                 230                 235                 240 


Asn Glu Asp Glu Phe Asn Gly Thr Gly Thr Cys Arg Asn Val Ser Thr 
                245                 250                 255     


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
            260                 265                 270         


Leu Asn Gly Ser Leu Ala Lys Glu Glu Val Arg Ile Arg Ser Glu Asn 
        275                 280                 285             


Ile Ser Asp Asn Ala Lys Thr Ile Ile Val Gln Phe Thr Lys Pro Val 
    290                 295                 300                 


Glu Ile Ile Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg 
305                 310                 315                 320 


Ile Gly Pro Gly Gln Ala Phe Tyr Gly Met Gly Asp Ile Ile Gly Asp 
                325                 330                 335     


Ile Arg Lys Ala His Cys Asn Val Ser Arg Ser Lys Trp Asn Glu Thr 
            340                 345                 350         


Leu Lys Lys Val Ala Ile Gln Leu Arg Lys Tyr Trp Asn Thr Thr Ile 
        355                 360                 365             


Ile Phe Thr Asn Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
    370                 375                 380                 


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe 
385                 390                 395                 400 


Asn Ser Ser Trp Asn Glu Asn Asp Thr Lys Val Asn Tyr Asn Thr Glu 
                405                 410                 415     


Ser Asn Asp Thr Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn 
            420                 425                 430         


Met Trp Gln Arg Thr Gly Gln Ala Thr Tyr Ala Pro Pro Ile Pro Gly 
        435                 440                 445             


Val Ile Gln Cys Arg Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
    450                 455                 460                 


Gly Gly Val Thr Asn Asn Thr Asn Asn Glu Thr Phe Arg Pro Gly Gly 
465                 470                 475                 480 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
                485                 490                 495     


Val Lys Leu Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Gln Arg Arg 
            500                 505                 510         


Val Val Lys Arg Glu Lys Arg Ala Val Gly Leu Ala Ala Val Phe Phe 
        515                 520                 525             


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr 
    530                 535                 540                 


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
545                 550                 555                 560 


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Arg Leu 
                565                 570                 575     


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Met Ala Val Glu 
            580                 585                 590         


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
        595                 600                 605             


Lys Ile Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Thr Trp Ser Asn 
    610                 615                 620                 


Lys Ser Tyr Thr Gln Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp 
625                 630                 635                 640 


Lys Glu Ile Ser Asn Tyr Thr Asp Ile Ile Tyr Gln Leu Ile Glu Glu 
                645                 650                 655     


Ser Gln Tyr Gln Gln Glu Lys Asn Glu Lys Glu Leu Leu Glu Leu Asp 
            660                 665                 670         


Lys Trp Ala Asn Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp 
        675                 680                 685             


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
    690                 695                 700                 


Ile Val Phe Ala Val Leu Thr Val Ile Lys Arg Val Arg Gln Gly Tyr 
705                 710                 715                 720 


Ser Pro Leu Ser Phe Gln Ile His Thr Pro Ser Pro Arg Asp Pro Asp 
                725                 730                 735     


Arg Pro Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Gly Arg Asp Arg 
            740                 745                 750         


Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu 
        755                 760                 765             


Arg Ser Leu Cys Arg Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Ser 
    770                 775                 780                 


Ile Ala Thr Arg Ile Val Glu Leu Leu Gly Gln Gly Leu Lys Tyr Leu 
785                 790                 795                 800 


Gly Asn Leu Leu Leu Tyr Trp Ile Arg Glu Leu Lys Ile Ser Ala Ile 
                805                 810                 815     


Ser Leu Phe Asp Thr Ile Ala Ile Ala Val Ala Gly Trp Thr Asp Arg 
            820                 825                 830         


Val Ile Glu Ile Gly Gln Arg Ile Gly Arg Ala Ile Leu His Ile Pro 
        835                 840                 845             


Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
    850                 855                 860 


<210> 199
<211> 884
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 199
Met Lys Val Arg Gly Ile Gln Arg Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Leu Ile Phe Gly Ile Ile Ile Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Val Met Pro Leu Ala Asp Val Thr Glu Val Phe Asn Met Trp Met 
                85                  90                  95      


Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Gln Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


His Cys His Tyr Val Ile Asn Asn Thr Ala His Lys Val Ser Val Ser 
    130                 135                 140                 


Pro Glu Met Gln Glu Lys Val Ala Asn Cys Ser Phe Asn Val Thr Thr 
145                 150                 155                 160 


Glu Leu Arg Asp Arg Lys Gln Lys Val Tyr Ser Leu Phe Tyr Arg Glu 
                165                 170                 175     


Asp Leu Val Pro Ile Asp Glu Asp Lys Asn Asn Ser Asn Ser Ala Ser 
            180                 185                 190         


Ile Ser Thr Ser Ser Asn Ser Ser Asn Cys Ser Ile Ser Asp Ser Asn 
        195                 200                 205             


Ser Thr Cys Ile Asn Ile Ser Thr Tyr Arg Leu Ile Asn Cys Asn Thr 
    210                 215                 220                 


Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro 
225                 230                 235                 240 


Ile His Tyr Cys Val Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Glu 
                245                 250                 255     


Lys Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Ser Val Gln 
            260                 265                 270         


Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn 
        275                 280                 285             


Gly Ser Leu Ala Lys Glu Thr Val Ile Ile Arg Thr Glu Asn Ile Ser 
    290                 295                 300                 


Asp Asn Gly Lys Asn Ile Ile Val Gln Phe Val Asp Pro Val Arg Ile 
305                 310                 315                 320 


Asn Cys Ile Arg Pro Asn Asn Asn Thr Arg Thr Ser Val Arg Ile Gly 
                325                 330                 335     


Pro Gly Gln Thr Phe Tyr Thr Ser Asp Ile Ile Gly Asp Ile Arg Gln 
            340                 345                 350         


Ala Tyr Cys Glu Val Asn Lys Thr Gln Trp Asn Met Thr Leu Gln Lys 
        355                 360                 365             


Val Ala Asp Gln Leu Arg Lys Phe Phe Pro Asn Lys Thr Ile Asn Phe 
    370                 375                 380                 


Asn Gln Thr Ser Gly Gly Asp Leu Glu Val Thr Thr His Ile Phe Asn 
385                 390                 395                 400 


Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Ser Leu Phe Asn Ser 
                405                 410                 415     


Ser Trp Pro Ile Asn Ser Thr Thr Ser Asn Asn Ser Thr Ala Ser Asn 
            420                 425                 430         


Glu Thr Ile Ile Leu Pro Cys Arg Ile Ile Gln Ile Ile Asn Met Trp 
        435                 440                 445             


Gln Arg Leu Gly Gln Ala Met Tyr Ala Pro Pro Ile Lys Gly Leu Ile 
    450                 455                 460                 


Asn Cys Val Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
465                 470                 475                 480 


Asp Arg Asn Ser Ser Tyr Glu Thr Phe Arg Pro Ile Gly Gly Asn Met 
                485                 490                 495     


Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
            500                 505                 510         


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Arg Arg Arg Val Val Glu 
        515                 520                 525             


Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Phe Phe Leu Gly Ile Leu 
    530                 535                 540                 


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
545                 550                 555                 560 


Gln Ala Arg Gln Val Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
                565                 570                 575     


Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp 
            580                 585                 590         


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
        595                 600                 605             


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
    610                 615                 620                 


Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln 
625                 630                 635                 640 


Gly Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile 
                645                 650                 655     


Ser Asn Tyr Thr Asp Ile Ile Tyr Lys Leu Ile Glu Glu Ser Gln Glu 
            660                 665                 670         


Gln Gln Glu Lys Asn Glu Leu Lys Leu Leu Ala Leu Asp Gln Trp Ala 
        675                 680                 685             


Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Arg 
    690                 695                 700                 


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe 
705                 710                 715                 720 


Ala Val Leu Ser Val Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
                725                 730                 735     


Ser Phe Gln Thr Leu Thr Pro Ser Pro Glu Gly Leu Asp Arg Pro Gly 
            740                 745                 750         


Lys Ile Glu Glu Gly Gly Gly Glu Gln Asp Arg Thr Arg Ser Ile Arg 
        755                 760                 765             


Leu Ala Ser Gly Phe Leu Ala Leu Ala Trp Glu Asp Leu Arg Ser Leu 
    770                 775                 780                 


Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala 
785                 790                 795                 800 


Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu 
                805                 810                 815     


Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Thr Tyr Trp Cys 
            820                 825                 830         


Gln Glu Leu Lys Thr Ser Ala Ile Ser Leu Phe Asp Thr Leu Ala Ile 
        835                 840                 845             


Ala Val Ala Glu Trp Thr Asp Arg Ile Ile Glu Val Gly His Arg Ile 
    850                 855                 860                 


Gly Arg Ala Phe Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu 
865                 870                 875                 880 


Arg Ala Leu Leu 
                


<210> 200
<211> 850
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 200
Met Arg Val Met Gly Thr Gln Met Asn Trp Gln Asn Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Ile Ile Ile Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Ile Pro Val Trp Arg Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asn Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Ser Val Thr Asn Ser Ser Val Thr Asn Ile Thr Ser Asp 
    130                 135                 140                 


Met Ala Gly Glu Ile Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Ile 
145                 150                 155                 160 


Arg Asp Lys Arg Gln Lys Val His Ala Leu Phe Tyr Arg Leu Asp Val 
                165                 170                 175     


Val Pro Met Asp Asn Asn Asn Ser Leu Tyr Arg Leu Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile 
        195                 200                 205             


Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn 
    210                 215                 220                 


Asp Lys Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Ser Val 
225                 230                 235                 240 


Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu 
                245                 250                 255     


Asn Gly Ser Leu Ala Glu Thr Glu Val Met Ile Arg Ala Glu Asn Ile 
            260                 265                 270         


Thr Asn Asn Ile Lys Asn Ile Ile Val Gln Phe Asn Lys Ser Val Glu 
        275                 280                 285             


Ile Ile Cys Ile Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile 
    290                 295                 300                 


Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala Tyr Cys Asp Val Asn Arg Thr Glu Trp Asn Glu Ala Leu 
                325                 330                 335     


Gln Lys Val Val Asn Gln Leu Lys Thr His Phe Lys Asn Lys Thr Ile 
            340                 345                 350         


Ile Phe Asn Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe 
    370                 375                 380                 


Asn Ser Thr Trp Asn Gly Thr Asp Ser Met Gln Lys Leu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
                405                 410                 415     


Gln Arg Ala Gly Gln Ala Ile Tyr Ala Pro Pro Ile Gln Gly Val Ile 
            420                 425                 430         


Arg Cys Glu Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly 
        435                 440                 445             


Asn Asp Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met 
    450                 455                 460                 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
465                 470                 475                 480 


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu 
                485                 490                 495     


Arg Glu Lys Arg Ala Ile Gly Ile Gly Ala Val Phe Ile Gly Phe Leu 
            500                 505                 510         


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
    530                 535                 540                 


Leu Met Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Ala Gln Val Leu Ala Val Glu Arg Tyr Leu 
                565                 570                 575     


Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp Ser Asp Val Ser Gln 
        595                 600                 605             


Ser Glu Ile Trp Glu Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile 
    610                 615                 620                 


Ser Asn Tyr Thr Gln Ile Ile Tyr Ser Leu Ile Glu Glu Ser Gln Asn 
625                 630                 635                 640 


Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala 
                645                 650                 655     


Asn Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile Lys 
            660                 665                 670         


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Ile 
        675                 680                 685             


Ala Val Ile Ser Ile Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
    690                 695                 700                 


Ser Phe Gln Ile His Thr Pro Ser Pro Gly Gly Leu Asp Arg Pro Gly 
705                 710                 715                 720 


Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asn Arg Ser Ile Arg 
                725                 730                 735     


Leu Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu 
            740                 745                 750         


Cys Leu Phe Cys Tyr Arg Arg Leu Arg Asp Phe Ile Leu Ile Val Ala 
        755                 760                 765             


Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Arg Gly Leu Arg Leu 
    770                 775                 780                 


Gly Trp Glu Gly Leu Lys Tyr Leu Lys Asn Leu Leu Ser Tyr Trp Gly 
785                 790                 795                 800 


Arg Glu Leu Lys Leu Ser Ala Ile Asn Leu Leu Asp Thr Ile Ala Ile 
                805                 810                 815     


Val Ile Ala Gly Trp Thr Asp Arg Val Ile Glu Ile Gly Gln Gly Phe 
            820                 825                 830         


Cys Arg Ala Ile Phe Pro Arg Arg Ser Lys Gln Gly Leu Lys Arg Ala 
        835                 840                 845             


Leu Gln 
    850 


<210> 201
<211> 873
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 201
Met Arg Val Met Gly Thr Gln Lys Asn Cys Pro Leu Leu Trp Arg Trp 
1               5                   10                  15      


Thr Leu Ile Phe Gly Leu Ile Ile Ile Cys Ser Ala Thr Gly Lys Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro Gln 
65                  70                  75                  80  


Glu Val Asp Leu Thr Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Ser Asn Ile Thr Ser Thr Ser Ser Asn Asn Asn Ser Ser Asn Ile 
    130                 135                 140                 


Thr Asn Ala Ser Ser Ser Ser Ser Asn Asn Ser Ser Asn Ser Thr Val 
145                 150                 155                 160 


Asp Glu Arg Asn Lys Val Met Thr Asn Cys Ser Phe Asn Met Thr Thr 
                165                 170                 175     


Glu Leu Arg Asp Lys Ile Gln Lys Val His Ser Leu Phe Tyr Arg Ser 
            180                 185                 190         


Asp Val Val Gly Ile Asn Gly Asn Lys Glu Tyr Arg Leu Ile Asn Cys 
        195                 200                 205             


Asn Thr Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro 
    210                 215                 220                 


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
225                 230                 235                 240 


Lys Asp Lys Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Ser 
                245                 250                 255     


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
            260                 265                 270         


Leu Asn Gly Ser Leu Ala Glu Glu Gly Ile Arg Ile Arg Ser Glu Asn 
        275                 280                 285             


Leu Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Thr Lys Pro Val 
    290                 295                 300                 


Arg Ile Asn Cys Thr Arg Pro Tyr Asn Asn Thr Arg Lys Ser Ile Arg 
305                 310                 315                 320 


Ile Gly Pro Gly Gln Ser Trp Tyr Ala Thr Gly Asp Ile Ile Gly Asn 
                325                 330                 335     


Ile Arg Gln Ala Phe Cys Asn Val Ser Lys Thr Asp Trp Asn Thr Ala 
            340                 345                 350         


Leu Gln Gln Val Ala Ala Gln Leu Gly Arg His Phe Asn Asn Lys Lys 
        355                 360                 365             


Ile Thr Phe Lys Asn Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His 
    370                 375                 380                 


Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu 
385                 390                 395                 400 


Phe Ser Gly Ser Trp Tyr Asn Gly Thr Trp Ala Asn Asp Ser Trp Ser 
                405                 410                 415     


Ala Gly Pro Gly Thr Asn Asp Asn Ile Thr Leu Pro Cys Lys Ile Lys 
            420                 425                 430         


Gln Ile Ile Arg Met Trp Gln Arg Val Gly Gln Ala Met Tyr Ala Pro 
        435                 440                 445             


Pro Ile Gln Gly Glu Ile Asn Cys Val Ser Asn Ile Thr Gly Leu Leu 
    450                 455                 460                 


Leu Thr Arg Asp Gly Gly Asn Ser Ser Glu Glu Ile Phe Arg Pro Gly 
465                 470                 475                 480 


Gly Gly Asp Ile Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
                485                 490                 495     


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Arg Arg 
            500                 505                 510         


Arg Val Val Gly Arg Glu Lys Arg Ala Val Gly Leu Gly Ala Val Phe 
        515                 520                 525             


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile 
    530                 535                 540                 


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
545                 550                 555                 560 


Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln His His Leu Leu Lys 
                565                 570                 575     


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
            580                 585                 590         


Glu Arg Phe Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
        595                 600                 605             


Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser 
    610                 615                 620                 


Asn Lys Ser Gln Glu Gln Ile Trp Asn Asn Met Thr Trp Leu Gln Trp 
625                 630                 635                 640 


Asp Arg Glu Ile Asp Asn Tyr Thr Gln Ile Ile Tyr Asn Leu Ile Glu 
                645                 650                 655     


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
            660                 665                 670         


Asp Lys Trp Ala Ser Leu Trp Thr Trp Phe Asp Ile Ser Asn Trp Leu 
        675                 680                 685             


Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu 
    690                 695                 700                 


Arg Ile Val Phe Ala Val Leu Ser Ile Met Asn Arg Val Arg Gln Gly 
705                 710                 715                 720 


Tyr Ser Pro Leu Ser Phe Gln Thr His Thr Pro Val Val Pro Thr Gly 
                725                 730                 735     


Pro Asp Arg Pro Gly Arg Ile Glu Glu Glu Ser Gly Glu Gln Asp Arg 
            740                 745                 750         


Asn Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp 
        755                 760                 765             


Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr Arg His Leu Arg Asp Phe 
    770                 775                 780                 


Ile Leu Ile Ala Ala Arg Ala Val Glu Leu Leu Gly His Ser Ser Leu 
785                 790                 795                 800 


Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu 
                805                 810                 815     


Leu Val Tyr Trp Gly Arg Glu Leu Lys Asn Ser Ala Ile Ser Leu Leu 
            820                 825                 830         


Asp Thr Val Ala Val Ala Val Ala Gly Trp Thr Asp Arg Val Ile Glu 
        835                 840                 845             


Ile Gly Gln Arg Val Gly Lys Ala Ile Ile His Ile Pro Arg Arg Ile 
    850                 855                 860                 


Arg Gln Gly Leu Glu Arg Ala Leu Leu 
865                 870             


<210> 202
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 202
Met Arg Val Met Gly Thr Gln Arg Asn Tyr Pro Pro Leu Trp Lys Leu 
1               5                   10                  15      


Gly Ile Met Val Leu Gly Met Ile Ile Ile Cys Cys Asn Ala Ala Asp 
            20                  25                  30          


Asn Leu Trp Ala Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala 
        35                  40                  45              


Glu Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Lys Thr Glu 
    50                  55                  60                  


Met His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Ile Lys Leu Asp Asn Val Thr Glu Glu Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asn Met Val Glu Gln Met His Ala Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Gln Leu Thr Pro Leu Cys Val Thr 
        115                 120                 125             


Leu Asn Cys Ser Asp Val Lys Val Asn Thr Thr Lys Asn Asn Gly Thr 
    130                 135                 140                 


Asn Ser Ser Asn Val Leu Val Ile Asn Gly Thr Glu Asn Gly Gln Glu 
145                 150                 155                 160 


Glu Leu Lys Asn Cys Ser Tyr Asn Val Thr Thr Glu Leu Arg Asp Lys 
                165                 170                 175     


Lys Gln Arg Val Tyr Ser Leu Phe Tyr Arg Leu Asp Ile Val Pro Ile 
            180                 185                 190         


Asn Glu Asp Asn Lys Ser Ser Asp Asn Ser Ser Gly Glu Tyr Arg Leu 
        195                 200                 205             


Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser 
    210                 215                 220                 


Phe Glu Pro Ile Pro Ile His Phe Cys Ala Pro Ala Gly Phe Ala Ile 
225                 230                 235                 240 


Leu Lys Cys Arg Asp Lys Asn Tyr Asn Gly Thr Gly Leu Cys Lys Asn 
                245                 250                 255     


Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr 
            260                 265                 270         


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile Lys Val Arg 
        275                 280                 285             


Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asp 
    290                 295                 300                 


Gln Pro Val Ile Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Arg 
305                 310                 315                 320 


Ser Val Arg Ile Gly Pro Gly Gln Ala Tyr Tyr Ala Thr Gly Glu Ile 
                325                 330                 335     


Ile Gly Asp Ile Arg Lys Ala Tyr Cys Thr Val Asn Lys Thr Ala Trp 
            340                 345                 350         


Asn Glu Thr Lys His Lys Val Met Glu Lys Leu Arg Gly Ile Tyr His 
        355                 360                 365             


Arg Pro Ile Lys Phe Asn Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr 
    370                 375                 380                 


Thr His Met Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
385                 390                 395                 400 


Gly Leu Phe Ala Gln Glu Leu Lys Asn Asp Thr Asn Asp Asn Asn Thr 
                405                 410                 415     


Ile Ile Leu Leu Cys Lys Ile Lys Gln Ile Ile Asn Met Trp Gln Arg 
            420                 425                 430         


Val Gly Gln Ala Met Tyr Ala Pro Pro Arg Ala Gly Val Ile Arg Cys 
        435                 440                 445             


Val Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Asn 
    450                 455                 460                 


Asp Asn Gly Thr Asn Gly Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp 
465                 470                 475                 480 


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Arg 
                485                 490                 495     


Ile Glu Pro Val Gly Val Ala Pro Thr Arg Ala Lys Arg Arg Val Val 
            500                 505                 510         


Glu Arg Glu Lys Arg Ala Val Gly Leu Gly Ala Val Phe Leu Gly Phe 
        515                 520                 525             


Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr Leu Thr 
    530                 535                 540                 


Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn 
545                 550                 555                 560 


Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Arg Leu Thr Val 
                565                 570                 575     


Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr 
            580                 585                 590         


Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu 
        595                 600                 605             


Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser 
    610                 615                 620                 


Tyr Glu Asp Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu 
625                 630                 635                 640 


Ile Ser Asn Tyr Thr Ala Leu Ile Tyr Asp Leu Ile Glu Glu Ser Gln 
                645                 650                 655     


Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Glu Leu Asp Lys Trp 
            660                 665                 670         


Ala Ser Leu Trp Asn Trp Phe Ser Ile Ser Gln Trp Leu Trp Tyr Ile 
        675                 680                 685             


Lys Ile Phe Ile Met Val Val Gly Gly Leu Ile Gly Leu Arg Ile Ile 
    690                 695                 700                 


Phe Ala Val Leu Ser Leu Val Asn Arg Val Arg Gln Gly Tyr Ser Pro 
705                 710                 715                 720 


Leu Ser Phe Gln Thr His Pro Pro Ala Pro Val Gly Leu Asp Arg Pro 
                725                 730                 735     


Gly Gly Ile Glu Glu Glu Gly Gly Glu Arg Gly Arg Asp Arg Ser Ile 
            740                 745                 750         


Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Asn 
        755                 760                 765             


Leu Cys Leu Phe Cys Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala 
    770                 775                 780                 


Ala Arg Thr Val Glu Leu Leu Gly Arg Asn Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 


Leu Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Ala Tyr Trp 
                805                 810                 815     


Gly Arg Glu Leu Lys Ile Ser Ala Ile Asn Leu Leu Asp Thr Ile Ala 
            820                 825                 830         


Ile Ala Val Gly Gly Trp Thr Asp Ser Leu Ile Glu Leu Thr Gln Arg 
        835                 840                 845             


Ile Gly Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Phe 
    850                 855                 860                 


Glu Arg Ala Leu Leu 
865                 


<210> 203
<211> 868
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 203
Met Arg Val Met Gly Ile Gln Met Asn Tyr Gln His Leu Leu Thr Trp 
1               5                   10                  15      


Gly Thr Ile Ile Leu Gly Met Ile Leu Ile Cys Ser Pro Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Ala Asn Val Thr Glu Asn Phe Asp Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Gln Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Met 
        115                 120                 125             


Asn Cys Ser Glu Pro Lys Phe Asn Asn Thr Asn Phe Asn Ser Thr Gly 
    130                 135                 140                 


Ser Asn Ser Thr Gly Ile Gln Glu Glu Met Arg Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Met Thr Thr Glu Leu Lys Asp Lys Lys Lys Glu Val Tyr Ser Leu Phe 
                165                 170                 175     


Tyr Arg Leu Asp Ile Val Gln Ile Asp Ser Lys Lys Gly Asn Ser Ser 
            180                 185                 190         


Asp Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Val Lys Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Ser Phe Asn Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
    210                 215                 220                 


Gly Phe Ala Ile Leu Lys Cys Arg Asp Glu Asp Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Met Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Lys Glu Asn 
            260                 265                 270         


Val Gln Ile Arg Ser Glu Asn Ile Ser Asn Asn Ala Lys Ile Ile Leu 
        275                 280                 285             


Val Gln Leu Ala His Pro Val Arg Ile Asn Cys Thr Arg Pro Gly Asn 
    290                 295                 300                 


Asn Thr Arg Lys Ser Ile His Met Gly Pro Gly Gln Ala Phe Tyr Ala 
305                 310                 315                 320 


Arg Gly Asp Val Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Val Ser 
                325                 330                 335     


Ser Ser Glu Trp Ser Asn Thr Leu Tyr Lys Val Ala Glu Gln Leu Arg 
            340                 345                 350         


Lys His Tyr Gly Asn Glu Thr Thr Ile Lys Phe Thr Asn His Ser Gly 
        355                 360                 365             


Gly Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe 
    370                 375                 380                 


Phe Tyr Cys Asn Thr Thr Asn Leu Phe Asn Ser Ser Ile Pro Phe Asn 
385                 390                 395                 400 


Ala Ser Glu Arg Ala Asn Asn Thr Asn Ser Thr Asp Asp Ile Ile Thr 
                405                 410                 415     


Leu Gln Cys Arg Ile Lys Gln Ile Val Arg Met Trp Gln Arg Val Gly 
            420                 425                 430         


Gln Ala Met Tyr Ala Pro Pro Ile Pro Gly Val Ile Arg Cys Glu Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Met Leu Thr Trp Asp Gly Gly Ser Lys Asn Ile 
    450                 455                 460                 


Thr Glu Gly Asn Arg Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
                485                 490                 495     


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Arg Arg Arg Val Val Gly 
            500                 505                 510         


Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Val Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln Gln Leu Leu Lys Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Leu Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Arg Leu Ile 
        595                 600                 605             


Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Tyr 
    610                 615                 620                 


Asn Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Arg Glu Ile 
625                 630                 635                 640 


Glu Asn Tyr Thr Gln Ile Ile Tyr Gly Leu Ile Glu Glu Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ser Leu Asn Lys Trp Ala 
            660                 665                 670         


Asp Leu Trp Ser Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
        675                 680                 685             


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe 
    690                 695                 700                 


Ala Val Leu Ser Val Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
705                 710                 715                 720 


Ser Phe Gln Thr His Leu Pro Asn Pro Gly Gly Leu Asp Arg Pro Glu 
                725                 730                 735     


Arg Ile Glu Glu Glu Asp Gly Glu Gln Gly Arg Thr Arg Ser Ile Arg 
            740                 745                 750         


Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu 
        755                 760                 765             


Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala 
    770                 775                 780                 


Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu 
785                 790                 795                 800 


Gly Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu Leu Val Tyr Trp Gly 
                805                 810                 815     


Arg Glu Leu Lys Thr Ser Ala Ile Ser Leu Val Asp Thr Ile Ala Ile 
            820                 825                 830         


Val Val Ala Gly Trp Thr Asp Arg Ala Ile Glu Ile Gly Gln Arg Ile 
        835                 840                 845             


Gly Arg Ala Ile Leu His Ile Pro Ile Arg Ile Arg Gln Gly Leu Glu 
    850                 855                 860                 


Arg Ala Leu Leu 
865             


<210> 204
<211> 858
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 204
Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Pro 
            20                  25                  30          


Glu Gln Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
        35                  40                  45              


Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr 
    50                  55                  60                  


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
65                  70                  75                  80  


Ser Pro Gln Glu Val Ala Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
                85                  90                  95      


Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu 
            100                 105                 110         


Trp Glu Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
        115                 120                 125             


Thr Leu Asn Cys Thr Asp Glu Leu Asn Asn Val Thr Ser Arg Ile Gly 
    130                 135                 140                 


Glu Lys Met Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr 
145                 150                 155                 160 


Ser Ile Arg Asp Lys Val Lys Lys Tyr Ala Leu Phe Tyr Lys Leu Asp 
                165                 170                 175     


Val Val Pro Ile Asp Asn Asp Asn Thr Thr Thr Asn Thr Thr Ala Asn 
            180                 185                 190         


Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro 
        195                 200                 205             


Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly 
    210                 215                 220                 


Phe Ala Ile Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Lys Gly Leu 
225                 230                 235                 240 


Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val 
                245                 250                 255     


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Gly Glu Glu Val 
            260                 265                 270         


Val Ile Arg Ser Asp Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val 
        275                 280                 285             


Gln Leu Lys Glu Ala Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn 
    290                 295                 300                 


Thr Arg Lys Ser Ile His Ile Gln Pro Gly Arg Ala Phe Tyr Thr Thr 
305                 310                 315                 320 


Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Leu Ser Lys 
                325                 330                 335     


Ala Asn Trp Asn Asn Thr Leu Lys Gln Ile Val Ile Lys Leu Arg Gln 
            340                 345                 350         


Gln Phe Asn Asn Lys Thr Ile Val Phe Asn His Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Pro Phe Asn Ser Thr 
385                 390                 395                 400 


Leu Asn Asp Thr Ser Thr Glu Gly Asn Ala Thr Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Lys Gln Val Val Asn Thr Trp Gln Glu Val Gly Lys Ala Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Leu Leu Thr Arg Asp Gly Gly Thr Ser Glu Asn Gly Thr Asn 
    450                 455                 460                 


Glu Ile Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly 
                485                 490                 495     


Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg 
            500                 505                 510         


Ala Val Gly Thr Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala 
        515                 520                 525             


Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg 
    530                 535                 540                 


Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala 
545                 550                 555                 560 


Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys 
                565                 570                 575     


Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln 
            580                 585                 590         


Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr 
        595                 600                 605             


Ala Val Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser Leu Asp Lys Ile 
    610                 615                 620                 


Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr 
625                 630                 635                 640 


Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 
                645                 650                 655     


Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 
            660                 665                 670         


Asn Trp Phe Asp Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile 
        675                 680                 685             


Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Ser Thr Val Leu 
    690                 695                 700                 


Ser Ile Ala Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln 
705                 710                 715                 720 


Thr Arg Leu Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu 
                725                 730                 735     


Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser Gly Arg Leu Val Asn 
            740                 745                 750         


Gly Leu Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe 
        755                 760                 765             


Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Ala Ala Arg Ile Val 
    770                 775                 780                 


Glu Leu Leu Gly Arg Arg Gly Trp Gly Ile Leu Lys Tyr Trp Trp Ser 
785                 790                 795                 800 


Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu 
                805                 810                 815     


Leu Asn Ala Thr Ala Ile Val Val Ala Glu Gly Thr Asp Arg Val Ile 
            820                 825                 830         


Glu Val Val Gln Arg Ile Tyr Arg Ala Phe Leu His Ile Pro Arg Arg 
        835                 840                 845             


Ile Arg Pro Gly Leu Glu Arg Ala Leu Leu 
    850                 855             


<210> 205
<211> 849
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 205
Met Lys Val Met Gly Thr Lys Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Ile Met Leu Leu Gly Met Leu Met Met Ser Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Asn 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Met Gly Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


His Cys Thr Asn Val Thr Ile Ser Ser Thr Asn Gly Ser Thr Ala Asn 
    130                 135                 140                 


Val Thr Met Arg Glu Glu Met Lys Asn Cys Ser Phe Asn Thr Thr Thr 
145                 150                 155                 160 


Val Ile Arg Asp Lys Ile Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu 
                165                 170                 175     


Asp Ile Val Pro Ile Glu Gly Lys Asn Thr Asn Thr Ser Tyr Arg Leu 
            180                 185                 190         


Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser 
        195                 200                 205             


Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile 
    210                 215                 220                 


Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Arg Asn 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Asp Ile Ile Ile Arg 
            260                 265                 270         


Ser Glu Asn Phe Thr Asn Asn Gly Lys Asn Ile Ile Val Gln Leu Lys 
        275                 280                 285             


Glu Pro Val Lys Ile Asn Cys Thr Arg Pro Gly Asn Asn Thr Arg Arg 
    290                 295                 300                 


Ser Ile Asn Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Ala Ile 
305                 310                 315                 320 


Ile Gly Asp Ile Arg Lys Ala His Cys Asn Ile Ser Thr Glu Gln Trp 
                325                 330                 335     


Asn Asn Thr Leu Thr Gln Ile Val Asp Lys Leu Arg Glu Gln Phe Gly 
            340                 345                 350         


Asn Lys Thr Ile Ile Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Val 
        355                 360                 365             


Val Met His Thr Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
    370                 375                 380                 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Asn Gly Thr Ser Thr Trp 
385                 390                 395                 400 


Asn Ser Thr Ala Asp Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Val 
                405                 410                 415     


Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile 
            420                 425                 430         


Arg Gly Gln Ile Asp Cys Ser Ser Asn Ile Thr Gly Leu Ile Leu Thr 
        435                 440                 445             


Arg Asp Gly Gly Ser Asn Ser Ser Gln Asn Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Lys Ile Glu Pro Leu Gly Ile Ala Pro Thr Arg Ala Lys Arg 
                485                 490                 495     


Arg Val Val Gln Arg Glu Lys Arg Ala Val Thr Leu Gly Ala Val Phe 
            500                 505                 510         


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu 
        515                 520                 525             


Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln 
    530                 535                 540                 


Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln 
545                 550                 555                 560 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile 
                565                 570                 575     


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
            580                 585                 590         


Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Thr Ser Trp Ser 
        595                 600                 605             


Asn Lys Ser Tyr Asp Tyr Ile Trp Asn Asn Met Thr Trp Met Gln Trp 
    610                 615                 620                 


Glu Arg Glu Ile Asp Asn Tyr Thr Gly Phe Ile Tyr Thr Leu Ile Glu 
625                 630                 635                 640 


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Leu Glu Leu Leu Glu Leu 
                645                 650                 655     


Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu 
            660                 665                 670         


Trp Tyr Ile Lys Leu Phe Ile Met Ile Ile Gly Gly Leu Val Gly Leu 
        675                 680                 685             


Arg Ile Val Cys Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly 
    690                 695                 700                 


Tyr Ser Pro Leu Ser Phe Gln Thr Arg Leu Pro Asn Pro Arg Gly Pro 
705                 710                 715                 720 


Asp Arg Pro Glu Glu Thr Glu Gly Glu Gly Gly Glu Arg Asp Arg Asp 
                725                 730                 735     


Arg Ser Ala Arg Leu Val Asn Gly Phe Leu Ala Ile Ile Trp Asp Asp 
            740                 745                 750         


Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu 
        755                 760                 765             


Leu Ile Val Ala Arg Val Val Glu Ile Leu Gly Arg Arg Gly Trp Glu 
    770                 775                 780                 


Ile Leu Lys Tyr Trp Trp Asn Leu Leu Lys Tyr Trp Ser Gln Glu Leu 
785                 790                 795                 800 


Lys Asn Ser Ala Val Ser Leu Leu Asn Val Thr Ala Ile Ala Val Ala 
                805                 810                 815     


Glu Gly Thr Asp Arg Val Ile Glu Ile Val Gln Arg Ala Val Arg Ala 
            820                 825                 830         


Ile Leu His Ile Pro Thr Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu 
        835                 840                 845             


Leu 
    


<210> 206
<211> 845
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 206
Met Arg Val Thr Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Asn Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr Ser Ser Thr Met Glu 
    130                 135                 140                 


Gly Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Ser Ile Lys 
145                 150                 155                 160 


Thr Lys Val Lys Asp Tyr Ala Leu Phe Tyr Lys Val Asp Val Val Pro 
                165                 170                 175     


Ile Gly Asn Asp Ser Thr Ser Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
            180                 185                 190         


Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile 
        195                 200                 205             


His Tyr Cys Thr Pro Ala Gly Phe Ala Ile Ile Lys Cys Asn Asn Lys 
    210                 215                 220                 


Lys Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys 
225                 230                 235                 240 


Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
                245                 250                 255     


Ser Leu Ala Glu Glu Glu Val Val Ile Lys Phe Ser Asn Phe Thr Asp 
            260                 265                 270         


Asn Ala Arg Val Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile Lys 
        275                 280                 285             


Cys Ile Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His Leu Gly Pro 
    290                 295                 300                 


Gly Lys Ala Trp Tyr Thr Thr Gly Gln Ile Ile Gly Asp Ile Arg Gln 
305                 310                 315                 320 


Ala His Cys Asn Leu Ser Ser Thr Lys Trp Asn Asn Thr Leu Lys Gln 
                325                 330                 335     


Ile Thr Lys Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe 
            340                 345                 350         


Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn 
        355                 360                 365             


Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gln Leu Phe Asn Ser 
    370                 375                 380                 


Thr Trp Asn Asp Thr Gly Thr Trp Asn Asp Thr Thr Gly Asn Ser Thr 
385                 390                 395                 400 


Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Val Asn Met Trp Gln Glu 
                405                 410                 415     


Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Glu Gly Gln Ile Arg Cys 
            420                 425                 430         


Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn 
        435                 440                 445             


Glu Ser Lys Pro Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
    450                 455                 460                 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
465                 470                 475                 480 


Pro Leu Gly Val Ala Pro Thr Lys Ala Arg Arg Arg Val Val Gln Arg 
                485                 490                 495     


Glu Lys Arg Ala Val Gly Thr Ile Gly Ala Met Phe Leu Gly Phe Leu 
            500                 505                 510         


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Arg Asn Leu 
    530                 535                 540                 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
                565                 570                 575     


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu 
        595                 600                 605             


His Glu Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile 
    610                 615                 620                 


Asp Asn Tyr Thr Arg Glu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn 
625                 630                 635                 640 


Gln Gln Glu Lys Asn Glu Leu Glu Leu Leu Glu Leu Asp Lys Trp Ala 
                645                 650                 655     


Ser Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp Leu Trp Tyr Ile Lys 
            660                 665                 670         


Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe 
        675                 680                 685             


Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
    690                 695                 700                 


Ser Leu Gln Thr Arg Phe Pro Ala Gln Arg Gly Pro Gly Arg Pro Glu 
705                 710                 715                 720 


Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser Glu Arg 
                725                 730                 735     


Leu Val Thr Gly Phe Leu Ser Leu Ile Trp Glu Asp Leu Arg Ser Leu 
            740                 745                 750         


Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Ala 
        755                 760                 765             


Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Val Leu Arg Tyr 
    770                 775                 780                 


Trp Trp Asn Leu Leu Gln Tyr Trp Ile Gln Glu Leu Lys Asn Ser Ala 
785                 790                 795                 800 


Ile Gly Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp 
                805                 810                 815     


Arg Val Ile Glu Val Val Gln Arg Ala Tyr Arg Ala Ile Leu His Ile 
            820                 825                 830         


Pro Thr Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
        835                 840                 845 


<210> 207
<211> 859
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 207
Met Thr Val Met Gly Ile Arg Lys Asn Cys Gln His Trp Leu Thr Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Ile Ile Cys Ser Ala Glu Asp Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Ser Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Glu Ala Lys Ala Tyr Ser Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp Glu 
            100                 105                 110         


Ser Leu Lys Pro Cys Ala Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asp Trp Lys Ser Asn Thr Thr Asn Thr Ser Ser Thr Thr Asn 
    130                 135                 140                 


Ala Thr Gln Ser Ser Trp Glu Asn Met Asn Gly Glu Ile Lys Asn Cys 
145                 150                 155                 160 


Ser Phe Asn Val Thr Thr Gln Ile Arg Asn Lys Val Arg Lys Glu Gln 
                165                 170                 175     


Ala Leu Phe Asn Ser Leu Asp Val Val Pro Ile Asp Asn Asn Asn Ser 
            180                 185                 190         


Met Tyr Met Leu Thr Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Ile Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
    210                 215                 220                 


Gly Phe Ala Ile Ile Lys Cys Asn Asp Lys Thr Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Thr Asn Val Ser Thr Val Gln Cys Val His Gly Ile Arg Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Asp 
            260                 265                 270         


Met Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile 
        275                 280                 285             


Val Gln Leu Asn Glu Thr Val Lys Ile Glu Cys Ile Arg Pro Asn Asn 
    290                 295                 300                 


Asn Thr Arg Lys Ser Ile Gln Leu Val Gly Gly Arg Ser Leu Tyr Ala 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Val Ser 
                325                 330                 335     


Ala Gln Asn Trp Thr Glu Thr Leu Lys Arg Val Ala Ile Lys Leu Arg 
            340                 345                 350         


Asp Gln Phe Glu His Lys Asn Lys Thr Ile Phe Leu Arg Pro Pro Ser 
        355                 360                 365             


Gly Gly Asp Pro Glu Ile Val Met Leu Thr Leu Asn Cys Gly Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asn Thr Thr Lys Leu Phe Asn His Asn Leu Thr Glu 
385                 390                 395                 400 


Asn Asn Thr Trp Gln Glu Asn Ala Ser Glu Ser Thr Ile Thr Leu Pro 
                405                 410                 415     


Cys Arg Ile Lys Gln Ile Ile Asn Arg Trp Gln Glu Val Gly Arg Ala 
            420                 425                 430         


Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Lys Cys Ser Ser Asn Ile 
        435                 440                 445             


Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Thr Asn Gly Ser Glu 
    450                 455                 460                 


Asn Gly Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn 
465                 470                 475                 480 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu 
                485                 490                 495     


Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys 
            500                 505                 510         


Arg Ala Val Gly Thr Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala 
    530                 535                 540                 


Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr 
        595                 600                 605             


Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Thr Asp Glu 
    610                 615                 620                 


Ile Trp Gly Asn Met Thr Trp Met Gln Trp Glu Arg Glu Ile Asp Asn 
625                 630                 635                 640 


Tyr Thr Glu Leu Ile Tyr Thr Leu Leu Glu Lys Ser Gln Asn Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Asn Leu 
            660                 665                 670         


Trp Ser Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe 
        675                 680                 685             


Ile Met Ile Val Gly Gly Leu Lys Gly Leu Arg Ile Ile Phe Thr Val 
    690                 695                 700                 


Phe Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe 
705                 710                 715                 720 


Gln Thr Arg Leu Pro Ala Gln Lys Gly Pro Asp Arg Pro Glu Glu Thr 
                725                 730                 735     


Glu Glu Gly Gly Gly Glu Arg Asp Arg Gly Arg Ser Thr Arg Leu Val 
            740                 745                 750         


His Gly Phe Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu 
        755                 760                 765             


Phe Ser Tyr His Arg Leu Ile Asp Leu Leu Ser Ile Val Ala Arg Ile 
    770                 775                 780                 


Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp 
785                 790                 795                 800 


Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Lys Ser Ala Val Ser 
                805                 810                 815     


Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val 
            820                 825                 830         


Ile Ala Val Ile Gln Ala Ile Gly Arg Ala Ile Ile His Ile Pro Arg 
        835                 840                 845             


Arg Ile Arg Gln Gly Ala Glu Ile Ala Leu Leu 
    850                 855                 


<210> 208
<211> 850
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 208
Met Lys Val Lys Glu Thr Arg Lys Ser Cys Gln His Leu Arg Gly Ile 
1               5                   10                  15      


Leu Leu Leu Gly Met Leu Met Ile Cys Ser Ala Glu Asp Gln Leu Trp 
            20                  25                  30          


Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr Thr 
        35                  40                  45              


Leu Ile Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Ala His Asn 
    50                  55                  60                  


Val Trp Ala Thr His Ala Cys Val Pro Thr Asn Pro Asn Pro His Glu 
65                  70                  75                  80  


Val Val Leu Glu Asn Val Thr Glu Lys Phe Asn Met Trp Lys Asn Asn 
                85                  90                  95      


Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser 
            100                 105                 110         


Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu His Cys 
        115                 120                 125             


Thr Asn Leu Thr Asn Ser Thr Thr Thr Ser Ile Ser Pro Thr Met Ser 
    130                 135                 140                 


Ile Gln Lys Ile Lys Asn Cys Ser Phe Asn Thr Thr Thr Ser Met Arg 
145                 150                 155                 160 


Asp Lys Ile Glu Lys Lys His Ala Leu Phe Tyr Asp Leu Asp Val Val 
                165                 170                 175     


Gln Ile Asp Asn Asp Lys Asn Lys Thr Asn Thr Arg Tyr Arg Leu Arg 
            180                 185                 190         


His Cys Ser Thr Ser Thr Leu Ala Cys Ala Trp Thr Asn Ile Asp Ser 
        195                 200                 205             


Val Pro Ile Pro Tyr Cys Ala Arg Ala Ala Phe Gly Ile Ala Ile Arg 
    210                 215                 220                 


Lys Cys Lys Asp Phe Asp Val Asn Gly Pro Cys Pro Cys Val Asn Ala 
225                 230                 235                 240 


Ala Gln Trp Thr Pro Gly Leu Lys Leu Lys Val Ser Ile Pro Leu Leu 
                245                 250                 255     


Leu Ile Val Ile Leu Ser Glu Gly Asp Ile Asp Ile Ala Ser Asp Thr 
            260                 265                 270         


Ile Ser Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Thr Val 
        275                 280                 285             


Gln Ile Ser Cys Thr Lys Pro Asn Asn Asn Thr Arg Lys Ser Ile His 
    290                 295                 300                 


Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Gln Ala Tyr Cys Asn Val Ser Gly Lys Ala Trp Asn Lys Thr 
                325                 330                 335     


Leu Gly Lys Val Val Ile Lys Leu Arg Glu Gln Phe Ile Asn Lys Thr 
            340                 345                 350         


Ile Val Phe Arg Arg Ser Ser Gly Gly Asp Pro Glu Ile Val Leu His 
        355                 360                 365             


Asn Phe Thr Cys Gly Gly Glu Phe Phe Tyr Trp Asn Thr Thr Ser Leu 
    370                 375                 380                 


Phe Asp Ser Thr Trp Asn Thr Asn Ala Thr Trp Asp Arg Asn Trp Asn 
385                 390                 395                 400 


Asp Thr Ser Gly Glu Asn Asp Ile Ile Thr Leu Pro Cys Arg Ile Lys 
                405                 410                 415     


Gln Ile Ile Tyr Met Gly Gln Glu Val Gly Lys Ala Met Tyr Ala Pro 
            420                 425                 430         


Pro Ile Thr Gly Leu Ile Ser Cys Ser Ser Asn Ile Thr Gly Leu Leu 
        435                 440                 445             


Leu Ile Gly Cys Gly Gly Glu Ser Tyr Asn Asp Glu Ile Phe Thr Pro 
    450                 455                 460                 


Gly Gly Gly Asn Met Lys Asp Tyr Trp Arg Ser Glu Leu Tyr Lys Tyr 
465                 470                 475                 480 


Asp Val Gln Glu Ile Glu Pro Leu Leu Val Ala Pro Thr Lys Ala Lys 
                485                 490                 495     


Arg Ile Val Val His Arg Glu Lys Arg Ala Phe Arg Phe Gly Ser Met 
            500                 505                 510         


Phe Leu Gly Phe Leu Glu Ala Pro Gly Ser Thr Met Gly Ala Ala Ser 
        515                 520                 525             


Ile Thr Leu Thr Val Gln Ala Ile Leu Leu Leu Ser Gly Ile Leu His 
    530                 535                 540                 


Gln His Ser Asn Leu Leu Lys Ala Ile Glu Ala His Gln Leu Leu Leu 
545                 550                 555                 560 


Leu Val Thr Val Ser Leu Ile Ser Asn Leu Gln Cys Arg Ile Pro Ala 
                565                 570                 575     


Glu Gln Arg Gln Leu Lys Tyr Arg Gln Leu Leu Gly Ile Cys Cys Cys 
            580                 585                 590         


Ser Gly Lys Ile His Tyr Ala Pro Ala Ala Pro Trp Asn Thr Ser Trp 
        595                 600                 605             


Ser Asn Arg Ser Arg Asp His Ile Leu His Asn Lys Thr Cys Arg Gln 
    610                 615                 620                 


Trp Glu Lys Glu Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile 
625                 630                 635                 640 


Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Leu Asp Phe Val Glu 
                645                 650                 655     


Leu Asp Lys Trp Ala Ser Leu Arg Asn Trp Phe Asp Lys Ser Asn Trp 
            660                 665                 670         


Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Val Leu Ile Gly 
        675                 680                 685             


Leu Arg Ile Met Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln 
    690                 695                 700                 


Gly Ser Ser Ser Leu Ser Cys Gln Thr Arg Phe Pro Ala Pro Arg Gly 
705                 710                 715                 720 


Pro Asp Arg Pro Glu Gly Ile Glu Glu Asp Gly Gly Glu Gln Gly Arg 
                725                 730                 735     


Asp Arg Ser Ile Arg Leu Val Asp Gly Phe Leu Ala Leu Ile Trp Asp 
            740                 745                 750         


Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu 
        755                 760                 765             


Leu Leu Ile Ala Ala Arg Val Val Glu Leu Leu Gly Arg Arg Gly Arg 
    770                 775                 780                 


Glu Ile Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Thr Gln Glu 
785                 790                 795                 800 


Leu Lys Lys Ser Ala Ile Ser Leu Phe Asn Ala Thr Ala Ile Ala Val 
                805                 810                 815     


Ala Glu Gly Thr Asp Arg Val Ile Glu Leu Leu Gln Arg Thr Gly Arg 
            820                 825                 830         


Ala Ile Leu His Ile Pro Val Arg Ile Arg Gln Gly Leu Glu Arg Leu 
        835                 840                 845             


Leu Leu 
    850 


<210> 209
<211> 855
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 209
Met Arg Val Arg Gly Ile Arg Lys Asn Tyr Arg His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Asp Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Pro 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Lys Thr Glu Met 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Leu Leu Gly Asn Met Thr Glu Asn Phe Asn Met Trp Glu 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Glu Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Tyr Asn Gly Asn Asn Thr Asn Ser Thr His Thr Asn 
    130                 135                 140                 


Ser Ser Ser Ser Glu Gly Glu Lys Leu Glu Lys Gly Glu Ile Lys Asn 
145                 150                 155                 160 


Cys Thr Phe Asn Ile Thr Thr Asn Ile Gly Asp Lys Gln Arg Asp Tyr 
                165                 170                 175     


Ala Phe Phe Tyr Lys Leu Asp Leu Glu Pro Ile Asn Lys Asp Asn Ala 
            180                 185                 190         


Ser Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
    210                 215                 220                 


Gly Phe Ala Leu Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
            260                 265                 270         


Val Val Ile Arg Ser Ala Asn Phe Ser Asn Asn Gly Lys Ile Ile Ile 
        275                 280                 285             


Val Gln Leu Asn Glu Thr Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
    290                 295                 300                 


Asn Thr Arg Lys Gly Ile Gln Leu Gly Gln Gly Arg Ala Leu Tyr Ala 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys Thr Ile Asn 
                325                 330                 335     


Gly Thr Lys Trp Asn Lys Thr Leu Asn Gln Ile Ala Glu Lys Leu Arg 
            340                 345                 350         


Glu Gln Phe Gly Glu Asn Lys Thr Ile Lys Phe Gln Pro Ser Ser Gly 
        355                 360                 365             


Gly Asp Pro Glu Val Val Met His Ser Phe Asn Cys Gly Gly Glu Phe 
    370                 375                 380                 


Phe Tyr Cys Asn Thr Ser Ser Leu Phe Asn Trp Ser Thr Asn Gly Ser 
385                 390                 395                 400 


Asn Ile Thr Asn Gly Ser Asn Ile Thr Lys Thr Ile Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys Ala Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Arg Gly Gln Ile Asn Cys Leu Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Leu Leu Thr Arg Asp Gly Gly Asn Gln Thr Glu Phe Asn Asn Thr Glu 
    450                 455                 460                 


Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Lys Ala Arg Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly 
            500                 505                 510         


Thr Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr 
        515                 520                 525             


Met Gly Ala Ala Ser Leu Thr Leu Thr Val Gln Ala Arg Leu Leu Leu 
    530                 535                 540                 


Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala 
545                 550                 555                 560 


Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
                565                 570                 575     


Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Gln Asp Gln Gln Leu Leu 
            580                 585                 590         


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro 
        595                 600                 605             


Trp Asn Ser Ser Trp Ser Asn Lys Thr Leu Asn Gln Ile Trp Glu Asn 
    610                 615                 620                 


Met Thr Trp Met Gln Trp Glu Arg Glu Ile Asp Asn Tyr Thr Arg Glu 
625                 630                 635                 640 


Ile Tyr Ser Leu Ile Glu Glu Ala Gln Asn Gln Gln Glu Lys Asn Glu 
                645                 650                 655     


Gln Asp Leu Leu Glu Leu Asp Lys Trp Asp Asn Leu Trp Ser Trp Phe 
            660                 665                 670         


Ser Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
        675                 680                 685             


Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val 
    690                 695                 700                 


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Arg Leu 
705                 710                 715                 720 


Pro Ala Gln Arg Gly Pro Asp Arg His Glu Glu Thr Gly Glu Glu Gly 
                725                 730                 735     


Gly Glu Arg Asp Arg Asp Thr Ser Gly Arg Leu Val Thr Gly Phe Leu 
            740                 745                 750         


Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Phe Leu Phe Ser Tyr His 
        755                 760                 765             


His Leu Arg Asp Leu Leu Leu Ile Val Ala Arg Ile Val Glu Leu Leu 
    770                 775                 780                 


Gly Arg Arg Gly Trp Glu Val Leu Lys Leu Trp Trp Asn Leu Leu Gln 
785                 790                 795                 800 


Tyr Trp Ser Gln Glu Ile Lys Asn Ser Ala Val Ser Leu Leu Asn Ala 
                805                 810                 815     


Thr Ala Ile Ile Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Ile Ala 
            820                 825                 830         


Gln Arg Thr Tyr Arg Ala Ile Leu His Ile Pro Thr Arg Ile Arg Gln 
        835                 840                 845             


Gly Leu Glu Arg Ala Leu Leu 
    850                 855 


<210> 210
<211> 867
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 210
Met Arg Val Thr Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Leu Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Asn 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Ala Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asp Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Val Arg Pro Leu Asn Cys Thr Asp Gly Lys Pro Pro 
    130                 135                 140                 


Asn Cys Thr Ala Val Glu Pro Ser Thr Ser Gly Asn Asn Ser Ser Ala 
145                 150                 155                 160 


Thr Gly Gly Gly Glu Met Lys Asn Cys Ser Phe Asn Val Thr Thr Ser 
                165                 170                 175     


Ile Arg Thr Lys Lys Thr Tyr Ala Thr Phe Tyr Asn Leu Asp Ile Val 
            180                 185                 190         


Lys Ile Asn Asp Asp Asn Asp Ser Thr Ser Thr Ser Tyr Arg Leu Ile 
        195                 200                 205             


Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
    210                 215                 220                 


Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Phe Ala Ile Leu 
225                 230                 235                 240 


Lys Cys Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Thr Asn Val 
                245                 250                 255     


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
            260                 265                 270         


Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Val Val Ile Arg Ser 
        275                 280                 285             


Ser Asn Phe Thr Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Glu 
    290                 295                 300                 


Pro Val Val Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
305                 310                 315                 320 


Ile Pro Leu Gly Pro Gly Gln Ala Trp Tyr Thr Thr Gly Asp Ile Ile 
                325                 330                 335     


Gly Asn Ile Arg Gln Ala His Cys Asn Leu Ser Arg Thr Glu Trp Asn 
            340                 345                 350         


Asn Thr Leu Arg Gln Ile Thr Lys Lys Leu Arg Glu His Ile Gly Asn 
        355                 360                 365             


Lys Thr Ile Thr Phe Asn Gln Ser Ala Gly Gly Asp Pro Glu Ile Val 
    370                 375                 380                 


Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
385                 390                 395                 400 


Gln Leu Phe Asn Ser Thr Trp Pro Trp Asn Asp Thr Ser Thr Gly Asn 
                405                 410                 415     


Asp Thr Thr Gly Asn Ser Thr Ile Thr Leu Pro Cys Lys Ile Arg Gln 
            420                 425                 430         


Ile Val Asn Arg Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro 
        435                 440                 445             


Ile Ala Gly Pro Ile Ser Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu 
    450                 455                 460                 


Thr Arg Asp Gly Gly Asn Gly Ser Ala Asp Asn Glu Thr Phe Arg Pro 
465                 470                 475                 480 


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
                485                 490                 495     


Lys Val Val Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys 
            500                 505                 510         


Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Thr Ile Gly Ala 
        515                 520                 525             


Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
    530                 535                 540                 


Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
545                 550                 555                 560 


Gln Gln Gln Arg Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 
                565                 570                 575     


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu 
            580                 585                 590         


Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly 
        595                 600                 605             


Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala Ser 
    610                 615                 620                 


Trp Ser Asn Lys Ser Leu Ser Gln Ile Trp Asp Asn Met Thr Trp Met 
625                 630                 635                 640 


Glu Trp Glu Arg Glu Ile Asn Asn Tyr Thr Lys Glu Ile Tyr Thr Leu 
                645                 650                 655     


Ile Glu Gln Ser Gln Asn Gln Gln Glu Lys Asn Glu Leu Glu Leu Leu 
            660                 665                 670         


Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn 
        675                 680                 685             


Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val Gly Gly Leu Val 
    690                 695                 700                 


Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg 
705                 710                 715                 720 


Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Arg Phe Pro Thr Gln Arg 
                725                 730                 735     


Gly Pro Gly Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp 
            740                 745                 750         


Arg Asp Arg Ser Glu Arg Leu Ala Asn Gly Phe Leu Thr Leu Phe Trp 
        755                 760                 765             


Glu Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His His Leu Arg Asp 
    770                 775                 780                 


Leu Leu Leu Ile Val Ala Arg Ile Val Glu Leu Leu Gly Arg Arg Gly 
785                 790                 795                 800 


Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ile Gln 
                805                 810                 815     


Glu Leu Lys Asn Arg Ala Val Ser Leu Phe Asn Ala Thr Ala Ile Ala 
            820                 825                 830         


Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val Val Gln Arg Ala Phe 
        835                 840                 845             


Arg Ala Val Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg 
    850                 855                 860                 


Ser Leu Leu 
865         


<210> 211
<211> 852
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 211
Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Leu Leu Ile Ile Cys Ser Ala Ala Glu Arg 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Val Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Trp Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Gly 
    130                 135                 140                 


Gly Thr Ile Glu Gly Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr 
145                 150                 155                 160 


Ala Gly Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Val Val Pro Ile Asp Asn Asp Asn Ser Ser Tyr Arg Leu Ile 
            180                 185                 190         


Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asp Lys Lys Phe Asp Gly Lys Gly Pro Cys Thr Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser 
            260                 265                 270         


Asp Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu 
        275                 280                 285             


Ser Ile Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Ile His Ile Gly Pro Gly Arg Ala Phe Tyr Thr Thr Gly Glu Ile Thr 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala His Cys Asn Leu Ser Arg Ala Lys Trp Asp 
                325                 330                 335     


Asn Thr Leu Lys Gln Ile Ala Asp Lys Leu Arg Lys Gln Leu Lys Asn 
            340                 345                 350         


Lys Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
        355                 360                 365             


Met His Ser Phe Thr Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr 
    370                 375                 380                 


Lys Leu Phe Asn Ser Thr Trp Asn Gly Thr Glu Gly Ser Asn Asn Ser 
385                 390                 395                 400 


Gly Thr Arg Ala Asn Asn Ser His Ile Leu Thr Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Ser Gly Thr Glu Ile Phe 
    450                 455                 460                 


Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
465                 470                 475                 480 


Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys 
                485                 490                 495     


Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Ile Gly 
            500                 505                 510         


Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
        515                 520                 525             


Ala Ser Met Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile 
    530                 535                 540                 


Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 
545                 550                 555                 560 


Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
                565                 570                 575     


Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp 
            580                 585                 590         


Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Thr 
        595                 600                 605             


Ser Trp Ser Asn Lys Ser Leu Ala Glu Ile Trp Asn Asn Met Thr Trp 
    610                 615                 620                 


Met Glu Trp Glu Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile Tyr Asn 
625                 630                 635                 640 


Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
                645                 650                 655     


Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr 
            660                 665                 670         


Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Ile Gly Gly Leu 
        675                 680                 685             


Val Gly Leu Arg Ile Val Phe Thr Val Leu Ser Ile Val Asn Arg Val 
    690                 695                 700                 


Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Leu Pro Ala Pro 
705                 710                 715                 720 


Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Gly Glu Asp Gly Glu Arg 
                725                 730                 735     


Asp Arg Asp Arg Ser Gly Arg Leu Val Gly Gly Phe Leu Ala Leu Phe 
            740                 745                 750         


Trp Val Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg 
        755                 760                 765             


Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg 
    770                 775                 780                 


Gly Trp Glu Val Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser 
785                 790                 795                 800 


Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala Ala Ala Ile 
                805                 810                 815     


Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Ile Leu Gln Arg Ala 
            820                 825                 830         


Gly Arg Ala Ile Leu His Ile Pro Thr Arg Ile Arg Gln Gly Leu Glu 
        835                 840                 845             


Arg Ala Leu Leu 
    850         


<210> 212
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 212
Met Lys Val Met Glu Thr Arg Arg Ser Trp Leu Pro Leu Trp Arg Gly 
1               5                   10                  15      


Gly Ile Leu Leu Leu Gly Ile Leu Met Ile Cys Ser Thr Glu Asn Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Ser Ser Glu Lys His 
    50                  55                  60                  


Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro Gln 
65                  70                  75                  80  


Glu Ile Pro Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asp Met Ala Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asn Leu Asn Cys Thr Ser Ser Gln Asn His Asn Thr Thr Cys 
    130                 135                 140                 


Arg Asn Val Ser Lys Glu Met Glu Gly Glu Ile Lys Asn Cys Ser Phe 
145                 150                 155                 160 


Tyr Thr Thr Thr Asn Ile Arg Asp Arg Val Thr Lys Asn Tyr Ala Leu 
                165                 170                 175     


Phe Tyr Ser Leu Asp Ile Val Pro Ile Asp Asp Asn Asn Asn Thr Asn 
            180                 185                 190         


Ile Ser Tyr Arg Leu Thr Ser Cys Asn Thr Ser Ile Ile Thr Gln Ala 
        195                 200                 205             


Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro 
    210                 215                 220                 


Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Gln Glu Phe Asn Gly Thr 
225                 230                 235                 240 


Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg 
                245                 250                 255     


Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys 
            260                 265                 270         


Asp Ile Val Ile Arg Ser Ser Asn Ile Ser Asp Asn Thr Lys Thr Ile 
        275                 280                 285             


Ile Val Gln Leu Lys Glu Ala Ile Ile Ile Asp Cys Ile Arg Pro Asn 
    290                 295                 300                 


Asn Asn Thr Arg Arg Ser Ile His Ile Gly Pro Gly Arg Ala Phe Tyr 
305                 310                 315                 320 


Gly Thr Gly Asp Ile Ile Gly Asn Ile Arg Gln Ala Tyr Cys Ser Ile 
                325                 330                 335     


Asn Ile Ser Lys Trp Asp Glu Thr Leu Arg Gln Ile Ala Gly Lys Leu 
            340                 345                 350         


Gly Glu Gln Leu Asn Lys Thr Lys Ile Ile Thr Phe Lys Asn Ser Ser 
        355                 360                 365             


Gly Gly Asp Pro Glu Ile Thr Met Phe Asn Phe Asn Cys Gly Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Ile Trp Thr Lys 
385                 390                 395                 400 


Asn Asp Asn Gly Ile Trp Thr Lys Asn Glu Thr Asn Gly Asn Trp Thr 
                405                 410                 415     


Arg Ser Gly Ser Thr Asn Asp Asn Asp Thr Ile Ile Leu Pro Cys Arg 
            420                 425                 430         


Ile Arg Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr 
        435                 440                 445             


Ala Pro Pro Ile Arg Gly Asn Ile Ser Cys Ser Ser Asn Ile Thr Gly 
    450                 455                 460                 


Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Asp Ser Ala Asn Glu 
465                 470                 475                 480 


Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu 
                485                 490                 495     


Leu Tyr Lys Tyr Lys Val Val Glu Ile Glu Pro Leu Gly Leu Ala Pro 
            500                 505                 510         


Thr Arg Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Ala Leu 
        515                 520                 525             


Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
    530                 535                 540                 


Ala Ala Ser Val Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Thr Gly 
545                 550                 555                 560 


Ile Val Gln Gln Gln Asn Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln 
                565                 570                 575     


His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 
            580                 585                 590         


Val Leu Ser Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile 
        595                 600                 605             


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn 
    610                 615                 620                 


Thr Ser Trp Ser Asn Lys Ser Val Asp Met Ile Trp His Asn Met Thr 
625                 630                 635                 640 


Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr 
                645                 650                 655     


Lys Leu Leu Glu Ala Ser Gln Asn Gln Gln Glu Gln Asn Glu Gln Glu 
            660                 665                 670         


Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
        675                 680                 685             


Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly 
    690                 695                 700                 


Leu Ile Gly Leu Arg Ile Val Phe Thr Val Leu Ser Ile Val Asn Arg 
705                 710                 715                 720 


Val Arg Lys Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Arg Pro Ala 
                725                 730                 735     


Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu 
            740                 745                 750         


Arg Asp Arg Asp Thr Ser Gly Pro Leu Val Thr Gly Phe Leu Ala Ile 
        755                 760                 765             


Ile Trp Val Asp Leu Arg Asn Leu Cys Leu Phe Ser Tyr His Arg Leu 
    770                 775                 780                 


Arg Asp Leu Leu Leu Ile Val Ala Arg Ile Val Glu Leu Leu Gly Arg 
785                 790                 795                 800 


Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp 
                805                 810                 815     


Ile Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Tyr Asn Thr Ile Ala 
            820                 825                 830         


Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Val Leu His Arg 
        835                 840                 845             


Ile Trp Arg Ala Ile Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Leu 
    850                 855                 860                 


Glu Arg Ala Leu Leu 
865                 


<210> 213
<211> 854
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 213
Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Pro His Trp Trp Arg Trp 
1               5                   10                  15      


Gly Ile Met Val Leu Gly Met Leu Met Ile Trp Ser Ala Lys Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Thr Val Trp Lys Gly Leu Pro 
        35                  40                  45              


Val Trp Lys Asn Ala Thr Thr Thr Leu Phe Cys Asp Thr Glu Leu His 
    50                  55                  60                  


Asn Val Arg Asp Lys Cys Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Val Val Met Gly Asn Val Thr Glu Tyr Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Arg 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Ile Phe Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Asn Asp Leu Lys Asn Val Thr Asn Thr Asn Cys Ser Ser Gly Arg 
    130                 135                 140                 


Gly Ile Val Glu Lys Leu Asp Ile Ser Asn Cys Ser Val Ser Ile Ser 
145                 150                 155                 160 


Thr Phe Ile Thr Gly His Val Val Ile Ala Asp Glu Val Met Asp Thr 
                165                 170                 175     


Asp Asp Ile Leu Leu Val Ser Ile Asp Ser Ile Asn Asn Lys Leu Thr 
            180                 185                 190         


Leu Cys Asn Thr Ser Leu Met Thr Gln Ala Cys Arg Ser Glu Arg Cys 
        195                 200                 205             


Lys Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser 
            260                 265                 270         


Glu Asn Phe Thr Asp Asn Thr Lys Thr Ile Ile Val Gln Leu Asn Glu 
        275                 280                 285             


Ser Val Val Ile Asn Cys Thr Arg Pro Ser Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Ile Arg Ile His Arg Gly Pro Gly Gln Ala Phe Phe Ala Thr Gly Lys 
305                 310                 315                 320 


Ile Gly Asp Ile Arg Gln Ala His Cys Asn Leu Ser Arg Ala Glu Trp 
                325                 330                 335     


Asn Lys Thr Leu Ala Gln Ile Ala Lys Lys Leu Gly Lys Gln Phe Gly 
            340                 345                 350         


Glu Asn Lys Thr Ile Ser Phe Gln Pro Ser Ser Gly Gly Asp Ile Glu 
        355                 360                 365             


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Thr Pro Leu Phe Asn Ser Ser Trp Tyr Lys Ser Asn Trp Lys Ser 
385                 390                 395                 400 


Gln Arg Thr Lys Glu Ile Gly Gly Arg Glu Thr Ile Thr Leu Gln Cys 
                405                 410                 415     


Arg Ile Lys Gln Ile Val Asn Met Trp Gln Glu Val Gly Arg Ala Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Lys Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr 
        435                 440                 445             


Gly Val Leu Leu Thr Arg Asp Gly Gly Asn Thr Thr Asn His Ser Glu 
    450                 455                 460                 


Ile Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Gln Ile Glu Pro Leu Gly Ile Ala Pro 
                485                 490                 495     


Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Ile Gly 
            500                 505                 510         


Phe Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
        515                 520                 525             


Gly Ala Ala Ser Val Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
    530                 535                 540                 


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Asn Ala Ile Gln Ala Gln 
545                 550                 555                 560 


Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
                565                 570                 575     


Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
            580                 585                 590         


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp 
        595                 600                 605             


Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Tyr Ile Trp Asp Asn Met 
    610                 615                 620                 


Thr Trp Met Glu Trp Glu Arg Glu Ile Asn Asn Tyr Thr Arg Leu Ile 
625                 630                 635                 640 


Tyr His Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys 
                645                 650                 655     


Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp 
            660                 665                 670         


Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly 
        675                 680                 685             


Gly Leu Ile Gly Leu Arg Ile Val Phe Val Val Leu Ser Ile Ile Asn 
    690                 695                 700                 


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Arg His Pro 
705                 710                 715                 720 


Ala Gln Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Gly Glu Gly Gly 
                725                 730                 735     


Glu Arg Asp Arg Gly Gly Ser Glu Arg Leu Val Asp Gly Phe Leu Ala 
            740                 745                 750         


Ile Ile Trp Val Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Ile Leu Thr Arg Ile Val Glu Leu Leu Gly 
    770                 775                 780                 


Arg Arg Ser Trp Glu Ala Leu Lys Tyr Cys Trp Asn Leu Leu Gln Tyr 
785                 790                 795                 800 


Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala Thr 
                805                 810                 815     


Ala Val Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Ile Val Gln 
            820                 825                 830         


Arg Ala Cys Arg Ala Phe Leu His Ile Pro Arg Arg Ile Arg Gln Gly 
        835                 840                 845             


Phe Glu Arg Leu Leu Leu 
    850                 


<210> 214
<211> 864
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 214
Met Arg Ala Lys Glu Met Lys Lys His Trp Gln Arg Ser Trp Lys Gly 
1               5                   10                  15      


Gly Ile Leu Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Ala Pro 
            20                  25                  30          


Asp Lys Trp Val Thr Val His Tyr Gly Val Pro Val Trp Arg Glu Ala 
        35                  40                  45              


Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Ser Thr Glu 
    50                  55                  60                  


Lys His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
        115                 120                 125             


Leu Asn Cys Ile Asp Glu Ile Thr Asn Arg Thr Asn Asn Thr His Lys 
    130                 135                 140                 


Asp Gly Gln Leu Met Asp Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Thr Thr Thr Ser Val Gln Asp Lys Leu Gln Lys Val Ser Ala Leu Phe 
                165                 170                 175     


Tyr Lys Pro Asp Val Val Arg Ile Gly Asp Asn Asn Asn Ser Ser Asn 
            180                 185                 190         


Ser Ser Ser Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ile Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Thr 
    210                 215                 220                 


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn Gly 
225                 230                 235                 240 


Ser Gly Leu Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Asn Glu Val Val Ile Lys Ser Glu Asn Phe Thr Asp Asn Ala Lys Thr 
        275                 280                 285             


Ile Ile Val Gln Leu Lys Glu Ala Val Gln Ile Asn Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala Phe 
305                 310                 315                 320 


Tyr Ala Thr Gly Asn Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys Thr 
                325                 330                 335     


Ile Asn Ile Thr Lys Trp Asn Lys Thr Leu Glu Gln Ile Val Asp Lys 
            340                 345                 350         


Leu Arg Asp Lys Phe Gly Glu Asn Lys Thr Ile Val Phe Asn Ser Ser 
        355                 360                 365             


Ala Gly Gly Asp Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn 
385                 390                 395                 400 


Leu Asn Ser Thr Trp Asn Gly Thr Lys Asn Leu Asn Asn Thr Thr Arg 
                405                 410                 415     


Asn Asp Thr Ile Ile Leu Pro Cys Arg Ile Arg Gln Ile Ile Asn Leu 
            420                 425                 430         


Trp Gln Lys Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln 
        435                 440                 445             


Ile Asn Cys Thr Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
    450                 455                 460                 


Gly Asn Thr Ser Glu Thr Asn Thr Thr Glu Val Phe Arg Pro Gly Gly 
465                 470                 475                 480 


Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
                485                 490                 495     


Val Glu Ile Glu Pro Ile Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg 
            500                 505                 510         


Val Val Gln Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu 
        515                 520                 525             


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Val Ala 
    530                 535                 540                 


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
545                 550                 555                 560 


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Lys Leu 
                565                 570                 575     


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu 
            580                 585                 590         


Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
        595                 600                 605             


Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Asn Ser Trp Ser Asn 
    610                 615                 620                 


Lys Ser Leu Glu Tyr Ile Trp Gly Asn Met Thr Trp Met Glu Trp Glu 
625                 630                 635                 640 


Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Asn Leu Ile Glu Glu 
                645                 650                 655     


Ser Gln Leu Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp 
            660                 665                 670         


Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp 
        675                 680                 685             


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg 
    690                 695                 700                 


Ile Val Phe Ala Val Leu Ala Ile Ala Asn Arg Val Arg Gln Gly Tyr 
705                 710                 715                 720 


Ser Pro Leu Ser Leu Gln Ile Arg Pro Pro Ala Gln Arg Gly Pro Asp 
                725                 730                 735     


Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Asp Arg Asp Arg Asp Thr 
            740                 745                 750         


Ser Thr Arg Leu Val His Gly Phe Leu Ala Leu Val Trp Asp Asp Leu 
        755                 760                 765             


Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu 
    770                 775                 780                 


Ile Val Thr Arg Ile Val Glu Leu Leu Gly His Arg Gly Trp Glu Ala 
785                 790                 795                 800 


Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ile Gln Glu Leu Lys 
                805                 810                 815     


Ser Ser Thr Val Ser Leu Phe Asn Tyr Thr Ala Ile Ala Val Ala Glu 
            820                 825                 830         


Gly Thr Asp Arg Ile Ile Glu Ile Val Gly Arg Val Phe Arg Ala Phe 
        835                 840                 845             


Ile His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Leu Leu Leu 
    850                 855                 860                 


<210> 215
<211> 853
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 215
Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Trp Trp Arg Trp 
1               5                   10                  15      


Gly Ile Met Leu Leu Gly Met Trp Met Ile Cys Ser Ala Asp Glu Met 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Ile Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Val Glu Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Ser Asn Leu Arg Asn Glu Thr Asn Ile Lys Asn Ala Thr Asn Ser 
    130                 135                 140                 


Ser Ser Gly Lys Val Met Glu Lys Gly Glu Met Lys Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Val Thr Thr Asn Ile Gly Asn Lys Val Gln Lys Glu Tyr Ala Leu 
                165                 170                 175     


Phe Tyr Lys Leu Asp Val Val Gln Ile Asp Asn Thr Ser Tyr Thr Leu 
            180                 185                 190         


Ile Asn Cys Asn Ser Ser Ile Ile Thr Gln Ala Cys Pro Lys Ile Ser 
        195                 200                 205             


Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Phe Ala Ile 
    210                 215                 220                 


Leu Gln Cys Asn Asp Lys Lys Phe Asn Gly Ser Gly Pro Cys Ser Asn 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg 
            260                 265                 270         


Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn 
        275                 280                 285             


Ala Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys 
    290                 295                 300                 


Ser Ile His Leu Gly Pro Gly Ser Thr Ile Tyr Ala Thr Gly Asp Ile 
305                 310                 315                 320 


Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Glu Thr Lys Trp 
                325                 330                 335     


Asn Asn Thr Leu Arg Gln Ile Val Ile Lys Leu Arg Glu Gln Phe Gly 
            340                 345                 350         


Asn Lys Thr Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu 
        355                 360                 365             


Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Ala Gln Leu Phe Asn Ser Thr Trp Ile Trp Asn Asp Thr Lys Gly 
385                 390                 395                 400 


Leu Asn Lys Thr Ala Glu Asn Gly Thr Phe Thr Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Arg Trp Gln Glu Val Gly Lys Ala Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Leu Leu Thr Arg Asp Gly Gly Ala Glu Ser Arg Asn Gly Thr Glu Ile 
    450                 455                 460                 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
465                 470                 475                 480 


Tyr Lys Tyr Lys Val Val Arg Ile Glu Pro Leu Gly Ile Ala Pro Thr 
                485                 490                 495     


Lys Ala Arg Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Thr 
            500                 505                 510         


Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
        515                 520                 525             


Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser 
    530                 535                 540                 


Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 
545                 550                 555                 560 


Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
                565                 570                 575     


Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
            580                 585                 590         


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp 
        595                 600                 605             


Asn Thr Ser Ser Asn Lys Ser Gln Asn Glu Ile Trp Asp Asn Met Thr 
    610                 615                 620                 


Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Asn Leu Ile Tyr 
625                 630                 635                 640 


Thr Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 
                645                 650                 655     


Leu Leu Glu Leu Asp Lys Trp Ser Asn Leu Trp Asn Trp Phe Ser Ile 
            660                 665                 670         


Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val Gly Gly 
        675                 680                 685             


Leu Ile Gly Leu Arg Ile Ile Phe Ser Val Leu Ser Ile Val Asn Arg 
    690                 695                 700                 


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Phe Pro Ser 
705                 710                 715                 720 


Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Gly Glu Gly Gly Glu 
                725                 730                 735     


Arg Asn Arg Asp Gly Ser Gly Pro Leu Val Asn Gly Phe Leu Thr Leu 
            740                 745                 750         


Ile Trp Val Asp Leu Arg Ser Leu Cys Leu Phe Ile Tyr Arg Arg Leu 
        755                 760                 765             


Arg Asp Leu Leu Leu Ile Val Ala Arg Ser Val Glu Leu Leu Gly Leu 
    770                 775                 780                 


Arg Gly Trp Glu Val Leu Lys Tyr Trp Trp Asn Leu Leu His Tyr Trp 
785                 790                 795                 800 


Ser Gln Glu Leu Lys Lys Ser Ala Val Ser Leu Leu His Ala Thr Ala 
                805                 810                 815     


Arg Ala Val Ala Glu Gly Thr Asp Arg Ala Ile Glu Ile Leu Gln Arg 
            820                 825                 830         


Ala Tyr Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu 
        835                 840                 845             


Glu Arg Ala Leu Leu 
    850             


<210> 216
<211> 854
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 216
Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Lys 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Thr 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Pro Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Pro Glu Val Val Leu Val Asn Val Thr Glu Asn Ser His Met Trp 
                85                  90                  95      


Thr Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Gly Thr Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Val Pro Ile Asp Asn Thr Ser Tyr Arg Leu Ile 
            180                 185                 190         


Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Thr Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr Ile Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Gly Glu Asp Val Val Ile Arg Ser 
            260                 265                 270         


Ala Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Thr 
        275                 280                 285             


Ser Val Glu Ile Asn Cys Thr Arg Pro Tyr Asn Asn Lys Arg Lys Ser 
    290                 295                 300                 


Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile Gly Lys 
305                 310                 315                 320 


Ile Gly Asn Met Arg Gln Ala His Cys His Ile Ser Arg Ala Lys Trp 
                325                 330                 335     


Asn Ala Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
            340                 345                 350         


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
        355                 360                 365             


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser Thr 
385                 390                 395                 400 


Glu Glu Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Lys Gln Phe Ile Asn Met Trp Gln Lys Val Gly Lys Ala Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Ser Gly Gln Ser Arg Cys Ser Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Asn Gly Ser Gln 
    450                 455                 460                 


Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Lys Ile Asp Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly 
            500                 505                 510         


Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
        515                 520                 525             


Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Ser Leu Ser 
    530                 535                 540                 


Gly Ile Val His Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 
545                 550                 555                 560 


Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
                565                 570                 575     


Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
            580                 585                 590         


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp 
        595                 600                 605             


Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn Met 
    610                 615                 620                 


Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile 
625                 630                 635                 640 


His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Glu Asn Glu Gln 
                645                 650                 655     


Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn 
            660                 665                 670         


Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Ile Ile Val Gly 
        675                 680                 685             


Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Val Ser Ile Val Asn 
    690                 695                 700                 


Arg Val Arg Gln Gly Tyr Ser Leu Leu Ser Phe Gln Thr His Leu Pro 
705                 710                 715                 720 


Ile Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly 
                725                 730                 735     


Glu Arg Asp Arg Gly Arg Ser Ile Arg Leu Val Asn Gly Ser Leu Ala 
            740                 745                 750         


Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg 
        755                 760                 765             


Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly 
    770                 775                 780                 


Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr 
785                 790                 795                 800 


Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Asn Leu Leu Asn Ala Thr 
                805                 810                 815     


Ala Ile Ala Val Ala Glu Gly Lys Asp Arg Val Ile Glu Val Leu Gln 
            820                 825                 830         


Ala Ala Tyr Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg Gln Gly 
        835                 840                 845             


Leu Glu Arg Ile Leu Leu 
    850                 


<210> 217
<211> 849
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 217
Met Ile Val Met Gly Ile Lys Lys Asn Tyr Gln His Leu Trp Thr Trp 
1               5                   10                  15      


Gly Met Met Leu Leu Gly Met Leu Met Ile Cys Ser Thr Ala Pro Ser 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Ala 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Pro Trp Tyr Asp Asn Thr Ala Asn Arg Thr Thr Glu 
    130                 135                 140                 


Arg Met Ile Met Glu Lys Gly Glu Ile Lys Lys Cys Ser Ile Glu Val 
145                 150                 155                 160 


Asn Thr Cys Leu Ile Asp Val Trp Met Glu His Cys Ala Leu Leu Ser 
                165                 170                 175     


Lys Leu His Leu Val Arg Leu Glu Asn Thr Thr Phe Ile Tyr Met Gln 
            180                 185                 190         


Thr Ser Arg His Ser Ser Lys Arg Thr Lys Gly Cys Pro Arg Tyr Ser 
        195                 200                 205             


Ile Glu Pro Ile Pro Leu Gln Tyr Ser Ala Pro Ala Gly Ser Ala Ile 
    210                 215                 220                 


Leu Ile Arg Lys Asn Asp Met Val His Gly Thr Gly Thr Cys Thr His 
225                 230                 235                 240 


Val Pro Pro Val Gln Cys Ser Asn Gly Ile Arg Pro Val Val Ser Ser 
                245                 250                 255     


Gln His Pro Ser His Asp Ile Ser Gly Ala Ala Val Leu Thr Lys Asp 
            260                 265                 270         


Asn Phe Lys Asp Thr Val Arg Thr Ile Ile Val Gln Leu Asn Asp Ser 
        275                 280                 285             


Val Pro Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile 
    290                 295                 300                 


His Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly 
305                 310                 315                 320 


Asp Ile Arg Gln Ala His Cys Asn Ile Ser Leu Val Lys Trp Asn Asn 
                325                 330                 335     


Thr Leu Glu Lys Ile Val Thr Lys Leu Arg Glu Gln Phe Lys Asn Lys 
            340                 345                 350         


Thr Ile Val Phe Ser Pro Pro Ser Gly Gly Asp Pro Glu Ile Val Ser 
        355                 360                 365             


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Pro 
    370                 375                 380                 


Leu Phe Asn Ser Thr Trp Asp Thr Asn Gly Thr Cys Lys Gly Ser Asn 
385                 390                 395                 400 


Ser Ala Asp Trp Asn Val Thr Val Pro Cys Ile Ser Ile Pro Ile Thr 
                405                 410                 415     


Thr Met Gly Gln Lys Leu Glu Gln Ala Met Asp Val Arg Pro Ile Ala 
            420                 425                 430         


Gly Lys Ala Ile Cys Ser Ser Ser Leu Ser Lys Gly Ile Leu Leu Ala 
        435                 440                 445             


Asn Ser His Asn Ser Ile Ile Val Pro Arg Leu Val Met Pro Lys Gly 
    450                 455                 460                 


Lys Asp Lys Lys Phe Asn Trp Asn Arg Lys Met Tyr Gln Cys Gln Val 
465                 470                 475                 480 


Gln Cys Gln Ile Glu Pro Leu Gly Val Ala Pro Thr Met Ala Lys Arg 
                485                 490                 495     


Arg Val Val Gln Arg Glu Lys Arg Asp Leu Gly Leu Gly Ala Leu Phe 
            500                 505                 510         


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile 
        515                 520                 525             


Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
    530                 535                 540                 


Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln 
545                 550                 555                 560 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
                565                 570                 575     


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
            580                 585                 590         


Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Ile Ser Trp Ser 
        595                 600                 605             


Asn Lys Thr Leu Glu Gln Ile Trp Asp Asn Met Thr Trp Met Gln Trp 
    610                 615                 620                 


Asp Lys Glu Ile His Asn Tyr Thr Glu Leu Ile Tyr Thr Leu Ile Glu 
625                 630                 635                 640 


Glu Ser Gln Ile Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 
                645                 650                 655     


Asp Lys Trp Ser Asn Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu 
            660                 665                 670         


Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu 
        675                 680                 685             


Arg Ile Val Phe Val Val Leu Ser Ile Ile Asn Arg Val Arg Lys Gly 
    690                 695                 700                 


Tyr Ser Pro Leu Ser Phe Gln Thr Leu Leu Pro Val Pro Arg Gly Pro 
705                 710                 715                 720 


Asp Arg Arg Phe Pro Ile Gly Glu Gly Asp Gly Glu Arg Asp Arg Asp 
                725                 730                 735     


Arg Asp Ser Arg Ser Ala Asn Gly Leu Leu Ala Ile Ile Asn Val Asp 
            740                 745                 750         


Met Arg Ile Leu Ser Leu Cys Ile Phe Leu Tyr Arg Arg Asp Leu Leu 
        755                 760                 765             


Leu Ile Val Met Met Thr Val Glu Leu Leu Gly Arg Arg Gly Trp Glu 
    770                 775                 780                 


Thr Leu Ile Tyr Cys Leu Asn Leu Asn Leu Tyr Leu Ser Gln Asn Leu 
785                 790                 795                 800 


Lys His Lys Ala Ile Ser Ile Ile Asn Val Thr Ala Thr Ala Val Ala 
                805                 810                 815     


Val Ala Ala Asp Thr Val Ile Asp Thr Val Pro Ala Ala Gly Arg Gly 
            820                 825                 830         


Ile Leu Leu Ile Leu Arg Arg Ile Arg Gln Gly Leu Glu Arg Asp Leu 
        835                 840                 845             


Leu 
    


<210> 218
<211> 859
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 218
Met Arg Val Lys Gly Ile Arg Lys Asn Trp Gln His Trp Trp Trp Lys 
1               5                   10                  15      


Trp Gly Ile Met Leu Leu Gly Met Trp Met Ile Cys Ser Thr Glu Glu 
            20                  25                  30          


Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
        35                  40                  45              


Ala Ser Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Lys Thr 
    50                  55                  60                  


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Ile Asp Pro 
65                  70                  75                  80  


Asp Pro Gln Glu Val Arg Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
                85                  90                  95      


Trp Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu 
            100                 105                 110         


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
        115                 120                 125             


Thr Leu Asn Cys Ser Ser Asn Val Thr Ile Ile Thr Asn Ser Thr Thr 
    130                 135                 140                 


Ala Asn Ser Ser Gly Lys Gly Ile Arg Asp Glu Leu Glu Met Lys Asn 
145                 150                 155                 160 


Cys Ser Phe Asn Val Ser Thr Asn Thr Asn Arg Lys Gly Phe Lys Glu 
                165                 170                 175     


Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Leu Asn Gly Thr Asp Asn Thr 
            180                 185                 190         


Ser Tyr Thr Leu Ile Asn Cys Asp Ser Ser Val Ile Lys Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
    210                 215                 220                 


Gly Phe Ala Ile Leu Gln Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Ser Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
            260                 265                 270         


Ile Val Ile Arg Ser Glu Asn Leu Thr Asp Asn Ala Lys Asn Ile Ile 
        275                 280                 285             


Val Gln Leu Asn Ala Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
    290                 295                 300                 


Asn Thr Arg Lys Gly Ile Gly Ile Gly Pro Gly Ser Ile Phe Tyr Ala 
305                 310                 315                 320 


Thr Gly Ala Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
                325                 330                 335     


Arg Ala Lys Trp Asn Asn Thr Leu Arg Gln Leu Ala Gly Glu Leu Glu 
            340                 345                 350         


Lys Arg Phe Asn Lys Thr Thr Ile Ile Phe Glu Gln Pro Leu Pro Gly 
        355                 360                 365             


Gly Asp Gln Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe 
    370                 375                 380                 


Phe Tyr Cys Asn Thr Ser Gln Leu Phe Asn Asn Thr Trp Asn Ser Thr 
385                 390                 395                 400 


Asp Lys Thr Leu Asn Asn Thr Glu Gly Asn Asp Thr Ile Thr Leu Pro 
                405                 410                 415     


Cys Arg Ile Arg Gln Ile Ile Asn Arg Trp Gln Glu Val Gly Lys Ala 
            420                 425                 430         


Met Tyr Ala Pro Pro Ile Ala Gly Ile Ile Thr Cys Ser Ser Asn Ile 
        435                 440                 445             


Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Thr Glu Asn Gly Thr Asn 
    450                 455                 460                 


Thr Thr Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn 
465                 470                 475                 480 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Arg Ile Glu Pro Leu 
                485                 490                 495     


Gly Ile Ala Pro Thr Arg Ala Arg Arg Ile Val Val Gln Arg Glu Lys 
            500                 505                 510         


Arg Ala Val Gly Thr Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Val Thr Leu Thr Val Gln Ala 
    530                 535                 540                 


Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Ile Glu Ala Gln Gln Arg Met Leu Gln Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr 
        595                 600                 605             


Thr Asn Val Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser Met Asn Asp 
    610                 615                 620                 


Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn 
625                 630                 635                 640 


Tyr Thr Gly Leu Ile Gln Thr Leu Leu Glu Glu Ser Gln Ile Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Thr Ser Leu 
            660                 665                 670         


Trp Asn Trp Phe Asp Ile Thr Lys Trp Leu Trp Tyr Ile Arg Ile Phe 
        675                 680                 685             


Ile Met Val Val Gly Gly Leu Val Gly Leu Arg Ile Ile Phe Phe Val 
    690                 695                 700                 


Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Leu 
705                 710                 715                 720 


Gln Thr His Leu Pro Ser Pro Arg Gly Pro Asp Arg Pro Gly Gly Thr 
                725                 730                 735     


Glu Gly Glu Gly Gly Glu Glu Asp Arg Gly Gly Ser Gly Arg Ser Val 
            740                 745                 750         


Asn Gly Phe Leu Ala Leu Ile Trp Val Asp Leu Arg Ser Leu Leu Leu 
        755                 760                 765             


Phe Ser Tyr Arg His Leu Arg Asp Leu Leu Leu Ile Leu Ala Arg Ser 
    770                 775                 780                 


Val Glu Leu Leu Gly Leu Arg Arg Trp Glu Ala Leu Lys Tyr Cys Trp 
785                 790                 795                 800 


Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser 
                805                 810                 815     


Leu Leu Asn Ala Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile 
            820                 825                 830         


Ile Glu Phe Leu Gln Gly Val Phe Arg Ala Phe Ile His Ile Pro Arg 
        835                 840                 845             


Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
    850                 855                 


<210> 219
<211> 823
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 219
Met Arg Val Lys Gly Ile Met Lys Asn Tyr Gln His Trp Trp Arg Trp 
1               5                   10                  15      


Gly Met Met Leu Leu Gly Met Trp Met Ile Cys Ser Ala Asn Lys Ser 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Ile Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Ile Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Ser Asn Leu Lys Asn Glu Thr Ala Asn Ser Thr Ser Ala Asn Ser 
    130                 135                 140                 


Asn Glu Thr Ala Asn Ser Thr Thr Ala Ser Asn Ser Thr Ser Asn Ser 
145                 150                 155                 160 


Ser Gly Glu Val Met Glu Glu Val Asp Met Lys Asn Cys Ser Phe Thr 
                165                 170                 175     


Val Thr Thr Glu Leu Lys Asn Thr Val Ser Lys Gln Tyr Ala Leu Phe 
            180                 185                 190         


Tyr Lys Cys Lys Pro Tyr Leu Lys Asn Gly Thr Gly Pro Cys Ser Asn 
        195                 200                 205             


Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr 
    210                 215                 220                 


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg 
225                 230                 235                 240 


Ser Glu Asn Phe Thr Asn Asn Ala Lys Asn Ile Ile Val Gln Leu Asn 
                245                 250                 255     


Ala Ser Val Glu Ile Asn Cys Thr Arg Pro Asp Asn Thr Ile Lys Asn 
            260                 265                 270         


Ile Arg Ile Gly Pro Gly Ile Gly Leu Gly Ser Thr Leu His Ala Thr 
        275                 280                 285             


Lys Ser Ile Thr Gly Arg Ile Arg Pro His Cys Asn Ile Ser Glu Ala 
    290                 295                 300                 


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ile Lys Leu Arg Glu Gln 
305                 310                 315                 320 


Phe Arg Asn Lys Thr Ile Ile Phe Asn His Ser Ser Gly Gly Asp Pro 
                325                 330                 335     


Glu Ile Glu Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
            340                 345                 350         


Asn Thr Thr Lys Leu Phe Asp Ser Thr Trp Asn Gly Thr Lys Glu Trp 
        355                 360                 365             


Asn Asp Thr Lys Glu Ser Asp Lys Asn Ile Thr Leu Gln Cys Arg Ile 
    370                 375                 380                 


Lys Gln Ile Ile Asn Arg Trp Gln Glu Val Gly Gln Ala Met Tyr Ala 
385                 390                 395                 400 


Pro Pro Ile Ser Gly Leu Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu 
                405                 410                 415     


Ile Leu Thr Arg Asp Gly Gly Ala Asn Glu Thr His Thr Asn Thr Glu 
            420                 425                 430         


Thr Phe Arg Pro Ala Gly Gly Asp Met Lys Asp Asn Trp Arg Ser Glu 
        435                 440                 445             


Leu Tyr Lys Tyr Lys Val Val Arg Ile Glu Pro Leu Gly Ile Ala Pro 
    450                 455                 460                 


Thr Lys Ala Arg Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly 
465                 470                 475                 480 


Ile Leu Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr 
                485                 490                 495     


Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
            500                 505                 510         


Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Asp Ala 
        515                 520                 525             


Gln Gln His Leu Leu Arg Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
    530                 535                 540                 


Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
545                 550                 555                 560 


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro 
                565                 570                 575     


Trp Asn Thr Ser Trp Ser Asn Lys Thr Gln Glu Asp Ile Trp Thr Asn 
            580                 585                 590         


Leu Thr Trp Met Gln Trp Glu Arg Glu Ile Asp Asn Tyr Thr Asn Val 
        595                 600                 605             


Ile Tyr Ser Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
    610                 615                 620                 


Gln Glu Leu Leu Gln Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
625                 630                 635                 640 


Asp Ile Thr Ser Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
                645                 650                 655     


Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Thr Val Leu Ser Ile Val 
            660                 665                 670         


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Phe 
        675                 680                 685             


Pro Ser Pro Arg Gly Pro Asp Arg Pro Gly Glu Ile Glu Gly Glu Gly 
    690                 695                 700                 


Gly Glu Glu Asp Arg Gly Gly Ser Asp Arg Leu Val Thr Gly Phe Leu 
705                 710                 715                 720 


Thr Leu Val Trp Val Asp Leu Arg Asn Leu Cys Leu Phe Ser Tyr Arg 
                725                 730                 735     


Ser Leu Arg Asp Leu Ile Leu Ile Val Ala Arg Ser Val Glu Leu Leu 
            740                 745                 750         


Gly Leu Arg Gly Trp Glu Val Leu Lys Tyr Cys Trp Ser Leu Leu Gln 
        755                 760                 765             


Tyr Trp Ser Gln Glu Leu Lys Lys Ser Ala Val Ser Leu Leu Gln Ala 
    770                 775                 780                 


Thr Ala Arg Ala Val Val Glu Gly Thr Asp Arg Val Ile Glu Thr Leu 
785                 790                 795                 800 


Gln Arg Ala Tyr Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln 
                805                 810                 815     


Gly Leu Glu Arg Ala Leu Leu 
            820             


<210> 220
<211> 892
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 220
Met Arg Val Lys Gly Ile Arg Arg Asn Trp Gln His Trp Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Thr Asp Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro Gln 
65                  70                  75                  80  


Glu Val Glu Leu Lys Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asp Trp Asn Gly Thr Ala Thr Ser Pro Asn Asp Asn Ser Tyr 
    130                 135                 140                 


Arg Gly Asn Lys Met Glu Lys Gly Glu Met Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Thr Thr Gly Ile Arg Asp Lys Ile Gln Lys Glu Tyr Ala Leu Phe 
                165                 170                 175     


Tyr Lys Leu Asp Met Val Pro Ile Asp Asp Asp Lys Thr Asn Ser Ser 
            180                 185                 190         


Pro Thr Thr Thr Thr Ser Ser Thr Leu Thr Ser Ser Ser Val Thr Asn 
        195                 200                 205             


Ser Asn Ser Asn Ser Ser Asn Thr Thr Ser Asn Ser Ser Gln Tyr Arg 
    210                 215                 220                 


Asn Tyr Arg Met Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
225                 230                 235                 240 


Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
                245                 250                 255     


Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Thr Gly Lys Gly 
            260                 265                 270         


Pro Cys Ser Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro 
        275                 280                 285             


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly 
    290                 295                 300                 


Ile Val Ile Arg Ser Asp Asn Phe Ser Asn Asn Ala Lys Asn Ile Leu 
305                 310                 315                 320 


Val Gln Leu Lys Glu Ala Val Val Ile Asn Cys Thr Arg Pro Asn Asn 
                325                 330                 335     


Asn Thr Arg Arg Gly Ile His Ile Gly Pro Gly Arg Ala Phe Tyr Thr 
            340                 345                 350         


Thr Gly Asp Val Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
        355                 360                 365             


Gly Thr Lys Trp Asn Asn Thr Leu Tyr Gln Ile Ala Lys Lys Leu Lys 
    370                 375                 380                 


Glu Gln Tyr Asn Glu Thr Asn Lys Ile Ile Phe Asn His Ser Ser Gly 
385                 390                 395                 400 


Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe 
                405                 410                 415     


Phe Tyr Cys Asn Thr Ala Lys Leu Phe Asn Ser Thr Leu Asn Asn Thr 
            420                 425                 430         


Glu Trp Ser Asn Ile Thr Ala Glu Asn Asn Glu Asp Lys Ile Ile Leu 
        435                 440                 445             


Gln Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys 
    450                 455                 460                 


Ala Met Tyr Ala Pro Pro Ile Ser Gly Pro Ile Asn Cys Ser Ser Ser 
465                 470                 475                 480 


Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ile Asn Asn Asn 
                485                 490                 495     


Ser Met Arg Asp Asn Asp Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
            500                 505                 510         


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Arg Ile Glu 
        515                 520                 525             


Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg 
    530                 535                 540                 


Glu Lys Arg Ala Val Gly Ile Gly Ala Val Leu Leu Gly Phe Leu Gly 
545                 550                 555                 560 


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Val Met Leu Thr Val Gln 
                565                 570                 575     


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu 
            580                 585                 590         


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
        595                 600                 605             


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu Gln 
    610                 615                 620                 


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Arg Leu Ile Cys 
625                 630                 635                 640 


Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Arg Ser Leu Asp 
                645                 650                 655     


Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp 
            660                 665                 670         


Asn Tyr Thr Asn Ile Ile Tyr Ser Leu Ile Gln Glu Ser Gln Asn Gln 
        675                 680                 685             


Gln Asp Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser 
    690                 695                 700                 


Leu Trp Asn Trp Phe Ser Ile Thr Gln Trp Leu Trp Tyr Ile Lys Ile 
705                 710                 715                 720 


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala 
                725                 730                 735     


Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
            740                 745                 750         


Leu Gln Thr Leu Leu Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu Gly 
        755                 760                 765             


Thr Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser Gly Gln Leu 
    770                 775                 780                 


Ala Asp Gly Leu Leu Thr Leu Ile Trp Val Asp Leu Arg Ser Leu Cys 
785                 790                 795                 800 


Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Ala Arg 
                805                 810                 815     


Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp 
            820                 825                 830         


Trp Asn Leu Leu Gln Tyr Trp Gly Arg Glu Ile Lys Asn Ser Ala Val 
        835                 840                 845             


Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg 
    850                 855                 860                 


Val Leu Glu Leu Leu Gln Arg Ile Gly Arg Gly Ile Leu His Ile Pro 
865                 870                 875                 880 


Arg Arg Ile Arg Gln Gly Leu Glu Arg Ser Leu Leu 
                885                 890         


<210> 221
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 221
Met Arg Val Lys Gly Ile Arg Arg Asn Tyr Gln His Leu Trp Trp Lys 
1               5                   10                  15      


Trp Gly Ile Met Leu Leu Gly Thr Leu Met Ile Tyr Ser Ala Ala Glu 
            20                  25                  30          


Gln Trp Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Asn Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser 
65                  70                  75                  80  


Pro Gln Glu Ile Asn Met Thr Asn Val Thr Glu Tyr Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asn Met Val Asp Gln Met His Glu Asp Ile Ile Asn Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Glu Leu Thr Pro Leu Cys Val Thr 
        115                 120                 125             


Leu Glu Cys Thr Asp Asn Ile Thr Thr Ser Ser Asn Thr Thr Arg Gly 
    130                 135                 140                 


Ser Asn Ser Ser Asn Arg Ser Arg Trp Glu Asn Met Thr Ile Glu Thr 
145                 150                 155                 160 


Gly Glu Ile Lys Lys Cys Ser Phe Asn Val Thr Thr Gly Ile Arg Asp 
                165                 170                 175     


Arg Val Asn Thr Glu Tyr Ala Tyr Phe Asn Arg Phe Asp Ile Val Gln 
            180                 185                 190         


Thr Glu Arg Asp Asn Lys Ser Tyr Thr Leu Arg His Cys Asn Thr Ser 
        195                 200                 205             


Val Ile Lys Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro Ile Pro Ile 
    210                 215                 220                 


Tyr Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys 
225                 230                 235                 240 


Thr Phe Ser Gly Lys Gly Glu Cys Asp Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Gly Val Val Ile Arg Ser Asp Asn Phe Ser Asp 
        275                 280                 285             


Asn Ala Lys Thr Ile Ile Val Gln Leu Thr Lys Ala Val Gln Ile Asn 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Gly Ile His Met Gly Pro 
305                 310                 315                 320 


Gly Lys Ala Phe Phe Thr Thr Gly Gln Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala Tyr Cys Asn Ile Ser His Thr Lys Trp Asn Asn Thr Leu Lys Gln 
            340                 345                 350         


Val Val Tyr Gln Leu Arg Lys Gln Tyr Gly Gly Asn Lys Thr Ile Asn 
        355                 360                 365             


Phe Thr Gln Pro Ser Gly Gly Asp Leu Glu Ile Val Thr His Ser Phe 
    370                 375                 380                 


Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn 
385                 390                 395                 400 


Thr Thr Trp Tyr Asn Asn Glu Thr Val Asp Asn Lys Thr Trp Thr Glu 
                405                 410                 415     


Asp Asp Thr Asn Leu Thr Asp Lys Asp Ile Ile Ile Leu Pro Cys Arg 
            420                 425                 430         


Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys Ala Met Tyr 
        435                 440                 445             


Ala Pro Pro Ile Gln Gly Met Ile Ser Cys Ser Ser Asn Ile Thr Gly 
    450                 455                 460                 


Leu Leu Leu Thr Arg Asp Gly Gly Asn Asp Thr Asp Thr Asp Pro Asn 
465                 470                 475                 480 


Gly Thr Glu Thr Phe Arg Pro Ile Gly Gly Asp Met Arg Asp Asn Trp 
                485                 490                 495     


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Arg Ile Glu Pro Leu Gly 
            500                 505                 510         


Ile Ala Pro Ser Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg 
        515                 520                 525             


Ala Ala Leu Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
    530                 535                 540                 


Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu 
545                 550                 555                 560 


Leu Ser Gly Ile Val Gln Gln Gln Ser Arg Leu Leu Arg Ala Ile Glu 
                565                 570                 575     


Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
            580                 585                 590         


Gln Ala Arg Val Leu Ala Leu Glu Arg Tyr Leu Gln Asp Gln Gln Ile 
        595                 600                 605             


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ser Val 
    610                 615                 620                 


Pro Trp Asn Ala Ser Trp Gly Asn Thr Ser Leu Gly Tyr Asp Tyr Ile 
625                 630                 635                 640 


Trp Thr Asn Trp Thr Trp Met Lys Trp Glu Lys Glu Ile Ala Asn Tyr 
                645                 650                 655     


Thr His Ile Ile Tyr Asp Leu Leu Glu Glu Ser Gln Ile Gln Gln Glu 
            660                 665                 670         


Gln Asn Glu Leu Glu Leu Met Lys Leu Asp Lys Trp Ala Ser Leu Trp 
        675                 680                 685             


Asp Trp Leu Gly Ile Thr Lys Trp Met Lys Tyr Ile Lys Ile Phe Ile 
    690                 695                 700                 


Ile Ile Val Val Gly Leu Val Gly Leu Arg Ile Ile Phe Ala Val Leu 
705                 710                 715                 720 


Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln 
                725                 730                 735     


Ile Arg Pro Pro Ala Ala Arg Glu Pro Asp Arg Pro Glu Glu Ile Glu 
            740                 745                 750         


Glu Gly Gly Gly Gly Arg Asp Arg Gly Arg Ser Asn Gln Leu Val Asp 
        755                 760                 765             


Gly Phe Leu Ala Leu Ile Trp Val Asp Leu Trp Ser Leu Cys Leu Phe 
    770                 775                 780                 


Ser Tyr Gln Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val 
785                 790                 795                 800 


Glu Leu Leu Gly Arg Arg Gly Trp Glu Ile Leu Lys Tyr Trp Trp Ser 
                805                 810                 815     


Leu Leu Gln Tyr Trp Gly Gln Glu Leu Lys Lys Ser Ala Val Ser Leu 
            820                 825                 830         


Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile 
        835                 840                 845             


Glu Ala Ala Gln Arg Val Phe Arg Ala Ile Ile His Ile Pro Arg Arg 
    850                 855                 860                 


Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
865                 870                 


<210> 222
<211> 862
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 222
Met Arg Val Lys Gly Ile Arg Lys Asn Cys Gln His Trp Trp Arg Trp 
1               5                   10                  15      


Gly Ile Met Leu Leu Gly Met Trp Met Ile Cys Ser Ala Ala Thr Gly 
            20                  25                  30          


Gly Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala 
        35                  40                  45              


Ile Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu 
    50                  55                  60                  


Met His Asn Val Trp Ala Thr His Ala Cys Val Pro Ile Asp Pro Asn 
65                  70                  75                  80  


Pro Leu Glu Val Asp Leu Pro Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Ile Thr Pro Leu Cys Val Val 
        115                 120                 125             


Leu Asn Cys Ser Asp Ala Lys Asn Ser Thr Ser Thr Asn Asn Ser Thr 
    130                 135                 140                 


Glu Lys Val Met Glu Lys Gly Glu Met Lys Asn Cys Ser Phe Asn Val 
145                 150                 155                 160 


Thr Thr Asn Ile Glu Asn Lys Val Lys Glu Ala Arg Ala Ile Phe Asp 
                165                 170                 175     


Lys Leu Asp Val Val Gln Ile Asp Asp Asn Asp Thr Asn Thr Met Ile 
            180                 185                 190         


Gly Ile Gln Tyr Tyr Lys Cys Tyr Ser Ser Ser Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Met Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala 
    210                 215                 220                 


Gly Phe Ala Ile Leu Gln Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
            260                 265                 270         


Ile Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile 
        275                 280                 285             


Val Gln Leu Asn Ala Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
    290                 295                 300                 


Asn Thr Arg Lys Ser Ile Pro Ile Gly Pro Gly Arg Ala Phe Tyr Ala 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Arg Ala His Cys Asn Ile Ser 
                325                 330                 335     


Lys Ala Thr Trp Asn Asn Thr Leu Arg Gln Leu Ala Ile Lys Leu Arg 
            340                 345                 350         


Glu Gln Leu Glu Asp Asn Thr Thr Thr Ile Ile Phe Lys Asn Ser Ser 
        355                 360                 365             


Gly Gly Asp Pro Glu Ile Glu Ala His Ser Phe Asn Cys Arg Glu Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asn Thr Thr Pro Leu Phe Asn Ser Ile Trp Tyr Ser 
385                 390                 395                 400 


Asn Asn Thr Glu Lys Ser Tyr Asn Thr Ala Glu Asn Asp Thr Ile Thr 
                405                 410                 415     


Leu Gln Cys Arg Ile Arg Gln Ile Ile Lys Arg Trp Gln Glu Val Gly 
            420                 425                 430         


Lys Ala Arg Tyr Ala Pro Leu Ile Thr Cys Leu Ile Arg Cys Tyr Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Leu Ala Gly Asp Gly Gly Glu Ala Gly Lys 
    450                 455                 460                 


Asp Asn Gly Asn Lys Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile 
                485                 490                 495     


Glu Pro Leu Arg Ile Ala Pro Thr Arg Ala Arg Arg Ile Val Val Gln 
            500                 505                 510         


Arg Glu Lys Arg Ala Val Gly Thr Leu Gly Ala Met Phe Leu Gly Phe 
        515                 520                 525             


Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr Leu Thr 
    530                 535                 540                 


Val Gln Ala Lys Gln Val Leu Ser Gly Ile Val Arg Gln Gln Asn Asn 
545                 550                 555                 560 


Leu Leu Arg Ala Ile Glu Ala Gln Gln Arg Leu Leu Gln Leu Thr Val 
                565                 570                 575     


Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr 
            580                 585                 590         


Leu Gln Asp Gln Arg Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu 
        595                 600                 605             


Ile Cys Thr Thr Ser Val Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser 
    610                 615                 620                 


His Asp Glu Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu 
625                 630                 635                 640 


Ile Asn Asn Tyr Thr Gln Val Ile Tyr Asp Leu Leu Glu Glu Ser Gln 
                645                 650                 655     


Ile Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Lys Leu Asp Ser Trp 
            660                 665                 670         


Ala Ser Leu Trp Lys Trp Leu Asp Ile Ser Asn Trp Leu Trp Tyr Ile 
        675                 680                 685             


Gln Ile Phe Met Met Met Val Gly Gly Leu Val Gly Leu Arg Ile Ile 
    690                 695                 700                 


Leu Cys Val Leu Ser Val Val Asn Arg Val Arg Gln Gly Tyr Ser Pro 
705                 710                 715                 720 


Leu Pro Phe Gln Thr His Leu Pro Ser Pro Arg Gly Leu Asp Arg Pro 
                725                 730                 735     


Gly Gly Ile Glu Gly Glu Gly Gly Glu Gly Asp Arg Ser Gly Ser Ser 
            740                 745                 750         


Gly Leu Ala Gly Gly Phe Leu Thr Leu Val Trp Val Asp Leu Arg Ser 
        755                 760                 765             


Leu Cys Leu Phe Ser Tyr His Ser Leu Arg Asp Leu Leu Leu Ile Val 
    770                 775                 780                 


Ala Arg Ser Val Glu Leu Leu Gly Leu Arg Gly Trp Glu Ile Leu Lys 
785                 790                 795                 800 


Tyr Trp Trp Ser Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Lys Ser 
                805                 810                 815     


Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr 
            820                 825                 830         


Asp Arg Val Ile Glu Ile Leu Gln Arg Ile Tyr Arg Ala Ile Leu His 
        835                 840                 845             


Ile Pro Thr Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
    850                 855                 860         


<210> 223
<211> 864
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 223
Val Arg Gly Thr Arg Lys Asn Tyr His His Tyr Leu Trp Arg Trp Gly 
1               5                   10                  15      


Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Gly Glu Gln Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Asp Thr Glu Val His 
    50                  55                  60                  


Asn Met Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asp Asn Leu Asp Asn Gly Thr Ile Ser Asn Ala Thr His Thr 
    130                 135                 140                 


Thr Asn Ser Ser Ser Val Asn Asn Thr Thr Gly Asn Ser Thr Arg Lys 
145                 150                 155                 160 


Leu Glu Ile Asp Arg Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr 
                165                 170                 175     


Thr Asn Ile Lys Asp Lys Met Gln Lys Ala His Ala Leu Phe Tyr Lys 
            180                 185                 190         


Leu Asp Val Val Pro Ile Asp Asn Ser Thr Thr Ser Tyr Arg Leu Ile 
        195                 200                 205             


Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
    210                 215                 220                 


Glu Pro Ile Pro Ile His Phe Cys Ala Pro Ala Gly Phe Ala Ile Leu 
225                 230                 235                 240 


Lys Cys Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Lys Asn Val 
                245                 250                 255     


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
            260                 265                 270         


Leu Leu Leu Asn Gly Ser Leu Ala Glu Asp Glu Val Val Ile Arg Ser 
        275                 280                 285             


Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu 
    290                 295                 300                 


Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Lys Thr Lys Arg Ser 
305                 310                 315                 320 


Phe His Ile Gly Pro Gly Arg Ala Phe Leu Thr Glu Ile Val Gly Asp 
                325                 330                 335     


Ile Arg Gln Ala Tyr Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr 
            340                 345                 350         


Leu His Gln Val Val Asn Lys Leu Arg Glu Gln Phe Gly Asn Arg Thr 
        355                 360                 365             


Ile Val Phe Lys Asn Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His 
    370                 375                 380                 


Met Phe Asn Cys Ala Gly Glu Phe Phe Tyr Cys Asn Thr Thr Lys Leu 
385                 390                 395                 400 


Phe Asn Ser Ile Trp Met Pro Asn Gly Thr Trp Asn Ser Thr Asp Thr 
                405                 410                 415     


Ser Asn Ser Thr Glu Ile Arg Leu Pro Cys Arg Ile Lys Gln Ile Val 
            420                 425                 430         


Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Ser 
        435                 440                 445             


Gly Arg Ile Arg Cys Val Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
    450                 455                 460                 


Asp Gly Gly Asn Asn Asn Glu Thr Thr Glu Ile Phe Arg Pro Gly Gly 
465                 470                 475                 480 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Leu 
                485                 490                 495     


Ile Lys Ile Glu Pro Leu Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg 
            500                 505                 510         


Val Val Gln Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Leu Leu 
        515                 520                 525             


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr 
    530                 535                 540                 


Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln 
545                 550                 555                 560 


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu 
                565                 570                 575     


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 
            580                 585                 590         


Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
        595                 600                 605             


Lys Leu Ile Cys Pro Thr Thr Val Pro Trp Asn Ala Ser Trp Ser Asn 
    610                 615                 620                 


Lys Asn Leu Ser Gln Ile Trp Asp Asn Met Thr Trp Met Glu Trp Glu 
625                 630                 635                 640 


Arg Glu Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu 
                645                 650                 655     


Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Glu Leu Asp 
            660                 665                 670         


Lys Trp Ala Ser Leu Trp Asn Trp Phe Ser Ile Thr Asn Trp Leu Trp 
        675                 680                 685             


Tyr Ile Lys Ile Phe Ile Ile Ile Val Gly Gly Leu Ile Gly Leu Arg 
    690                 695                 700                 


Met Val Phe Thr Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr 
705                 710                 715                 720 


Ser Pro Leu Ser Phe Gln Thr Arg His Pro Ala Pro Arg Gly Pro Asp 
                725                 730                 735     


Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp Thr 
            740                 745                 750         


Ser Gly Phe Leu Val Asp Gly Phe Leu Ala Ile Ile Trp Val Asp Leu 
        755                 760                 765             


Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu 
    770                 775                 780                 


Ile Val Ala Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala 
785                 790                 795                 800 


Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Gly Lys Glu Leu Lys 
                805                 810                 815     


Ser Ser Ala Ile Ser Leu Phe Asn Ala Thr Ala Ile Ala Val Ala Glu 
            820                 825                 830         


Gly Thr Asp Arg Val Ile Glu Val Ile Gln Arg Ala Cys Arg Ala Ile 
        835                 840                 845             


Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Gln 
    850                 855                 860                 


<210> 224
<211> 855
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 224
Met Arg Ala Lys Gly Ile Arg Lys Asn Cys Gln His Trp Trp Arg Gly 
1               5                   10                  15      


Val Thr Leu Leu Leu Gly Met Leu Met Ile Cys Asn Ala Ala Gln Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp 
        35                  40                  45              


Thr Ile Leu Phe Cys Ala Ser Asp Ala Lys Gly Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Arg Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Lys Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Asn Lys Asn Ser Thr Gln Gly Asn Ala Thr Ala 
    130                 135                 140                 


Glu Glu Gln Glu Glu Ile Arg Asn Cys Ser Phe Asn Ile Thr Thr Ser 
145                 150                 155                 160 


Ile Arg Asp Arg Met Lys Lys Asp Tyr Ala Leu Phe Tyr Ser Asn Asp 
                165                 170                 175     


Ile Val Lys Leu Asp Asn Asn Thr Phe Arg Leu Thr Ser Cys Asn Thr 
            180                 185                 190         


Ser Val Ile Thr Gln Ala Cys Pro Lys Ile Ser Phe Asn Pro Ile Pro 
        195                 200                 205             


Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp 
    210                 215                 220                 


Thr Thr Phe Asn Gly Ser Gly Leu Cys Arg Asn Val Ser Ser Val Gln 
225                 230                 235                 240 


Cys Thr His Gly Ile Lys Pro Val Val Ser Thr His Phe Leu Leu Asn 
                245                 250                 255     


Gly Ser Leu Ala Glu Lys Glu Val Val Ile Arg Ser Glu Asn Phe Thr 
            260                 265                 270         


Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Lys Asp Pro Val Arg Ile 
        275                 280                 285             


Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Gly Ile His Ile Gly 
    290                 295                 300                 


Pro Gly Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg 
305                 310                 315                 320 


Gln Ala His Cys Asn Ile Ser Arg Thr Glu Trp Asn Lys Thr Leu Asn 
                325                 330                 335     


Gln Val Val Glu Lys Leu Arg Ala Gln Phe Asn Asn Lys Thr Ile Val 
            340                 345                 350         


Phe Lys Asn Ala Ser Gly Gly Asp Pro Glu Ile Val Met His Ile Phe 
        355                 360                 365             


Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn 
    370                 375                 380                 


Ser Thr Trp Asn Ala Asn Ser Thr Trp Asn Asp Thr Ser Ser Asn Ile 
385                 390                 395                 400 


Gly Glu Ser Asn Asp Thr Ile Thr Leu Pro Cys Lys Ile Arg Gln Ile 
                405                 410                 415     


Val Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile 
            420                 425                 430         


Ala Gly Gln Leu Asn Cys Ser Ser Asn Ile Thr Gly Ile Leu Leu Thr 
        435                 440                 445             


Arg Asp Gly Gly Glu Ser Asn Thr Thr Asn Ser Asn Glu Thr Phe Arg 
    450                 455                 460                 


Pro Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Lys Leu Tyr Lys 
465                 470                 475                 480 


Tyr Lys Val Ile Lys Ile Glu Pro Leu Gly Leu Ala Pro Thr Lys Ala 
                485                 490                 495     


Lys Arg Arg Val Val Gln Arg Lys Ala Arg Ala Ala Gly Leu Gly Ala 
            500                 505                 510         


Val Ile Phe Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
        515                 520                 525             


Ser Val Ala Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
    530                 535                 540                 


Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met 
545                 550                 555                 560 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu 
                565                 570                 575     


Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly 
            580                 585                 590         


Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Asp Ser 
        595                 600                 605             


Trp Ser Pro Arg Trp Ser Lys Glu Asn Met Ser Lys Ile Trp Asp Asn 
    610                 615                 620                 


Met Thr Trp Asn Gln Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Tyr 
625                 630                 635                 640 


Ile Tyr Thr Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
                645                 650                 655     


Gln Asp Leu Leu Ser Leu Asp Lys Trp Ala Asp Leu Trp Ser Trp Phe 
            660                 665                 670         


Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
        675                 680                 685             


Gly Gly Leu Val Gly Leu Arg Ile Ile Phe Ser Val Leu Ala Ile Val 
    690                 695                 700                 


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Leu 
705                 710                 715                 720 


Pro Ala Arg Arg Gly Pro Glu Gly Pro Glu Glu Ile Glu Glu Gly Gly 
                725                 730                 735     


Gly Glu Arg Asp Arg Asp Arg Ser Arg Pro Leu Val Asp Gly Phe Leu 
            740                 745                 750         


Thr Leu Ile Trp Ile Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
        755                 760                 765             


Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Thr Leu Glu Leu Leu 
    770                 775                 780                 


Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Cys Trp Asn Leu Leu Gln 
785                 790                 795                 800 


Tyr Trp Gly Gln Glu Leu Arg Ser Ser Ala Val Ser Leu Phe Asn Ala 
                805                 810                 815     


Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Ile Ile 
            820                 825                 830         


Gln Arg Ile Phe Arg Ala Tyr Ser Phe Ser Ala Pro Thr Leu Lys Asn 
        835                 840                 845             


Asp Met Ala Leu Ala Leu Gly 
    850                 855 


<210> 225
<211> 850
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 225
Met Arg Val Lys Glu Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Thr Thr Ser Ser Ser Gly 
    130                 135                 140                 


Gly Thr Met Glu Arg Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr 
145                 150                 155                 160 


Thr Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr Thr Thr Ser Tyr Arg 
            180                 185                 190         


Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         


Arg Ser Asp Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             


Lys Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 


Lys Ser Ile His Ile Gly Pro Gly Arg Ala Phe Tyr Thr Thr Gly Glu 
305                 310                 315                 320 


Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Leu Ser Arg Ala Lys 
                325                 330                 335     


Trp Asp Asn Thr Leu Lys Gln Ile Val Arg Lys Leu Arg Glu Gln Phe 
            340                 345                 350         


Gly Asn Lys Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu 
        355                 360                 365             


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp 
    370                 375                 380                 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Asn Val Thr Glu Gly Ser Asn 
385                 390                 395                 400 


Asn Thr Glu Gly Asn Ile Thr Leu Thr Leu Pro Cys Arg Ile Lys Gln 
                405                 410                 415     


Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro 
            420                 425                 430         


Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu 
        435                 440                 445             


Thr Arg Asp Gly Gly Asn Asn Glu Ser Glu Thr Glu Ile Phe Arg Pro 
    450                 455                 460                 


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
465                 470                 475                 480 


Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys 
                485                 490                 495     


Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val 
            500                 505                 510         


Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser 
        515                 520                 525             


Met Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln 
    530                 535                 540                 


Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu 
545                 550                 555                 560 


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala 
                565                 570                 575     


Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys 
            580                 585                 590         


Ser Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Ala Ser Trp 
        595                 600                 605             


Ser Asn Lys Ser Leu Asp Lys Ile Trp Asn Asn Met Thr Trp Met Glu 
    610                 615                 620                 


Trp Glu Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile 
625                 630                 635                 640 


Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 
                645                 650                 655     


Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp 
            660                 665                 670         


Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly 
        675                 680                 685             


Leu Arg Ile Val Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln 
    690                 695                 700                 


Gly Tyr Ser Pro Leu Ser Phe Gln Thr Arg Leu Pro Ala Pro Arg Gly 
705                 710                 715                 720 


Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg 
                725                 730                 735     


Asp Arg Ser Gly Arg Leu Val Asp Gly Phe Leu Ala Leu Phe Trp Val 
            740                 745                 750         


Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu 
        755                 760                 765             


Leu Leu Ile Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp 
    770                 775                 780                 


Glu Val Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu 
785                 790                 795                 800 


Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala Val 
                805                 810                 815     


Ala Glu Gly Thr Asp Arg Val Ile Glu Val Leu Gln Arg Thr Cys Arg 
            820                 825                 830         


Ala Ile Leu His Ile Pro Thr Arg Ile Arg Gln Gly Leu Glu Arg Ala 
        835                 840                 845             


Leu Leu 
    850 


<210> 226
<211> 920
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 226
Met Arg Val Lys Glu Met Arg Lys His Trp Gln His Leu Trp Thr Gly 
1               5                   10                  15      


Gly Ile Leu Leu Leu Gly Met Leu Met Ile Cys Ser Thr Ala Gln Asp 
            20                  25                  30          


Ala Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Lys Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Glu Leu Ile Val Thr Asn Ser Thr Asn Gly Asn Asn 
    130                 135                 140                 


Thr Asn Ser His Ser Thr Arg Gly Asn Asp Thr Ile Gly Asn Ser Thr 
145                 150                 155                 160 


Ser Trp Lys Glu Met Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile 
                165                 170                 175     


Pro Thr Ser Val Lys Asp Lys Met Gln Lys Gln Tyr Ala Leu Phe Tyr 
            180                 185                 190         


Lys Leu Asp Val Val Ala Ile Asn Asp Asp Asn Asn Lys Asn Ser Ser 
        195                 200                 205             


Asn Tyr Asn Ser Ser Lys Leu Ser Ser Ser Asn Ser Asn Cys Lys Ser 
    210                 215                 220                 


Asp Asn Asn Ser Ser Cys Asn Cys Ser Ser Ser Asn Asn Asn Cys Ser 
225                 230                 235                 240 


Ser Ser Asn His Ser Ser Asn Tyr Ser Ser Tyr Ile Leu Ile Ser Cys 
                245                 250                 255     


Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro 
            260                 265                 270         


Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Phe Ala Ile Leu Lys Cys 
        275                 280                 285             


Asn Asp Lys Arg Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr 
    290                 295                 300                 


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
305                 310                 315                 320 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn 
                325                 330                 335     


Ile Ser Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Ser Val 
            340                 345                 350         


Ala Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Gly Ile Arg 
        355                 360                 365             


Ile Gly Pro Gly Arg Thr Phe Tyr Ala Ala Glu Lys Ile Ile Gly Asp 
    370                 375                 380                 


Ile Arg Lys Ala Tyr Cys Ile Ile Asn Gly Thr Lys Trp Asn Glu Thr 
385                 390                 395                 400 


Leu Arg Leu Ile Val Ala Lys Leu Arg Glu Gln Glu Gln Ile Gly Glu 
                405                 410                 415     


Asn Thr Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Asp Pro Glu Ile 
            420                 425                 430         


Glu Asn His Ile Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr 
        435                 440                 445             


Thr Gln Leu Phe Asn Ser Thr Trp Tyr Ser Asn Gly Thr Trp Ile Gly 
    450                 455                 460                 


Lys Asn Phe Thr Gly Ser Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln 
465                 470                 475                 480 


Ile Val Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro 
                485                 490                 495     


Ile Arg Gly Gln Ile Asn Cys Ile Ser Asn Ile Thr Gly Leu Leu Leu 
            500                 505                 510         


Thr Ser Asp Gly Gly Phe Arg Lys Thr Asn Glu Thr Thr Asn Met Thr 
        515                 520                 525             


Glu Thr Leu Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser 
    530                 535                 540                 


Glu Leu Tyr Lys Tyr Lys Val Val Arg Ile Glu Pro Leu Gly Ile Ala 
545                 550                 555                 560 


Pro Thr Gln Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val 
                565                 570                 575     


Gly Ile Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
            580                 585                 590         


Thr Met Gly Ala Ala Ala Leu Thr Leu Thr Val Gln Ala Arg Gln Leu 
        595                 600                 605             


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
    610                 615                 620                 


Ala Gln His Gln Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
625                 630                 635                 640 


Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu 
                645                 650                 655     


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val 
            660                 665                 670         


Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser Leu Thr Glu Ile Trp Asn 
        675                 680                 685             


Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Glu Asn Tyr Thr Gly 
    690                 695                 700                 


Leu Ile Tyr Asn Leu Leu Glu Lys Ser Gln Asn Gln Gln Glu Lys Asn 
705                 710                 715                 720 


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Asn Leu Trp Asn Trp 
                725                 730                 735     


Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile 
            740                 745                 750         


Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
        755                 760                 765             


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Ile Ser Leu Gln Thr His 
    770                 775                 780                 


Leu Pro Val Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Gly Glu 
785                 790                 795                 800 


Gly Gly Glu Arg Asp Gly Asp Thr Ser Arg Arg Leu Val Ile Gly Leu 
                805                 810                 815     


Leu Pro Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
            820                 825                 830         


His Arg Leu Arg Asp Leu Leu Leu Ile Val Ala Arg Ile Val Glu Leu 
        835                 840                 845             


Leu Gly Arg Arg Gly Trp Glu Ile Leu Lys Tyr Trp Trp Asn Leu Leu 
    850                 855                 860                 


Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
865                 870                 875                 880 


Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Ile 
                885                 890                 895     


Ala Arg Thr Ile Phe Arg Ala Phe Tyr His Ile Pro Arg Arg Ile Arg 
            900                 905                 910         


Gln Gly Phe Glu Arg Ala Leu Leu 
        915                 920 


<210> 227
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 227
Met Arg Val Lys Glu Thr Gln Met Asn Trp Pro Asn Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Leu Val Ile Ile Cys Ser Ala Ser Asp Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Asp 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Val Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Tyr Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Gly Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Thr Cys Thr Asn Ala Ser Leu Thr Lys Ile Asn Thr Thr Thr Ser Asp 
    130                 135                 140                 


Pro Lys Ile Gly Asn Ile Thr Asp Glu Val Arg Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Val Thr Thr Glu Ile Glu Asp Lys Lys Gln Arg Val Ser Ala Leu Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Val Pro Met Glu Asp Asn Ser Asn Ser Ser Glu 
            180                 185                 190         


Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Lys Gln Ala Cys Pro 
        195                 200                 205             


Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly 
    210                 215                 220                 


Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Thr Gly Thr Gly Gln 
225                 230                 235                 240 


Cys Lys Asn Val Ser Ser Val Gln Cys Thr His Gly Ile Arg Pro Thr 
                245                 250                 255     


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile 
            260                 265                 270         


Met Ile Arg Thr Glu Ser Leu Thr Asn Asn Ala Lys Thr Ile Ile Val 
        275                 280                 285             


His Leu Asn Lys Ser Val Glu Ile Asn Cys Thr Arg Pro Ser Asn Asn 
    290                 295                 300                 


Thr Arg Thr Ser Ile Thr Ile Gly Pro Gly Arg Val Phe Tyr Arg Thr 
305                 310                 315                 320 


Gly Asp Ile Ile Gly Asp Ile Arg Arg Ala Tyr Cys Glu Ile Asn Glu 
                325                 330                 335     


Thr Asn Trp Tyr Lys Val Leu Lys Gln Val Thr Gly Lys Leu Lys Glu 
            340                 345                 350         


His Phe Asn Lys Thr Ile Asn Phe Gly Pro Pro Ser Gly Gly Asp Leu 
        355                 360                 365             


Glu Ile Thr Met His His Phe Thr Cys Arg Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Thr Lys Leu Phe Ile Asn Asn Cys Thr Arg Asn Glu Thr Lys 
385                 390                 395                 400 


Gly Gly Cys Asn Ser Thr Ile Asn Gly Thr Ile Ile Leu Pro Cys Arg 
                405                 410                 415     


Ile Lys Gln Ile Ile Asn Met Trp Gln Gly Ala Gly Gln Ala Met Tyr 
            420                 425                 430         


Ala Pro Pro Ile Ser Gly Arg Ile Asn Cys Val Ser Asn Ile Thr Gly 
        435                 440                 445             


Ile Leu Leu Thr Arg Asp Gly Gly Ile Thr Ser Asn Gly Thr Asn Gly 
    450                 455                 460                 


Thr Asn Gly Thr Asn Gly Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp 
465                 470                 475                 480 


Ile Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Gln 
                485                 490                 495     


Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Arg Arg Arg Val Val 
            500                 505                 510         


Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Met Ile Phe Gly Phe 
        515                 520                 525             


Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr 
    530                 535                 540                 


Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn 
545                 550                 555                 560 


Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val 
                565                 570                 575     


Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr 
            580                 585                 590         


Leu Lys Asp Gln Lys Phe Leu Gly Leu Trp Gly Cys Ser Gly Lys Ile 
        595                 600                 605             


Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser 
    610                 615                 620                 


Tyr Asp Gln Ile Trp His Asn Met Thr Trp Ile Glu Trp Glu Arg Glu 
625                 630                 635                 640 


Ile Ser Asn Tyr Thr Asn Gln Ile Tyr Glu Ile Leu Thr Glu Ser Gln 
                645                 650                 655     


Asn Gln Gln Asp Arg Asn Glu Lys Asp Leu Leu Glu Leu Asp Lys Trp 
            660                 665                 670         


Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Arg Trp Leu Trp Tyr Ile 
        675                 680                 685             


Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile 
    690                 695                 700                 


Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro 
705                 710                 715                 720 


Leu Ser Phe Gln Thr Pro Thr Leu His Gln Arg Glu Pro Asp Arg Pro 
                725                 730                 735     


Glu Arg Ile Glu Glu Gly Gly Gly Glu Gln Asp Arg Asp Arg Ser Val 
            740                 745                 750         


Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser 
        755                 760                 765             


Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Ser Ile Ala 
    770                 775                 780                 


Ala Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 


Leu Gly Trp Glu Gly Leu Lys Tyr Leu Gly Asn Leu Leu Leu Tyr Trp 
                805                 810                 815     


Gly Gln Glu Leu Lys Ile Ser Ala Ile Ser Leu Leu Asp Ala Thr Ala 
            820                 825                 830         


Ile Ala Val Ala Gly Trp Thr Asp Arg Val Ile Glu Gly Ala Gln Arg 
        835                 840                 845             


Ala Trp Arg Ala Phe Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu 
    850                 855                 860                 


Glu Arg Ala Leu Gln 
865                 


<210> 228
<211> 860
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 228
Met Lys Val Arg Val Ile Arg Met Ser Tyr Gln Gln Leu Trp Lys Gly 
1               5                   10                  15      


Gly Thr Leu Leu Leu Gly Met Leu Met Ile Cys Ser Ala Val Gly Pro 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Ala 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asp Pro 
65                  70                  75                  80  


Arg Glu Val Val Leu Glu Asn Leu Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Glu Gln Met His Gln Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asp Phe Asn Gly Thr Val Thr Asn Asn Ser Ser Gly Asn 
    130                 135                 140                 


Ala Thr Asp Asn Ser Ser Gly Ser Gly Leu Glu Arg Glu Thr Thr Gly 
145                 150                 155                 160 


Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Asp Met Lys Asp Lys 
                165                 170                 175     


Val Gln Glu Lys Tyr Ala Leu Phe Tyr Lys Leu Asp Ile Val Ser Ile 
            180                 185                 190         


Asp Glu Ser Arg Asn Gly Ser Ser Tyr Arg Leu Thr Ser Cys Asn Thr 
        195                 200                 205             


Ser Val Leu Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro 
    210                 215                 220                 


Ile His Phe Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn 
225                 230                 235                 240 


Lys Arg Phe Asn Gly Ala Gly Pro Cys Thr Asn Val Ser Thr Val Gln 
                245                 250                 255     


Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn 
            260                 265                 270         


Gly Ser Leu Ala Glu Glu Lys Val Ile Ile Arg Ser Lys Asn Phe Ser 
        275                 280                 285             


Asp Asn Thr Lys Ile Ile Ile Val Gln Leu Asn Glu Ser Val Val Ile 
    290                 295                 300                 


Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly 
305                 310                 315                 320 


Pro Gly Arg Ala Phe Tyr Gly Thr Glu Ile Ile Gly Asp Ile Arg Lys 
                325                 330                 335     


Ala His Cys Thr Leu Asn Arg Thr Gln Trp Asn Asn Thr Leu Gln Arg 
            340                 345                 350         


Val Ala Thr Glu Leu Arg Glu Gln Phe Lys Asn Lys Thr Ile Gly Phe 
        355                 360                 365             


Thr Asn Ser Ser Gly Gly Asp Leu Glu Ile Thr Met His Ser Phe Asn 
    370                 375                 380                 


Cys Gly Gly Glu Phe Phe Phe Cys Asn Thr Thr Lys Leu Phe Gly Gly 
385                 390                 395                 400 


Thr Trp Asp Gly Ser Thr Trp Asn Trp Ser Asp Asn Glu Asn Asn Thr 
                405                 410                 415     


Ile Thr Ile Thr Leu Pro Cys Arg Lys Lys Leu Ile Ile Asn Met Gln 
            420                 425                 430         


Gln Glu Glu Glu Lys Ala Thr Tyr Ala Asn Thr Ile Arg Gly Pro Ile 
        435                 440                 445             


Lys Ser Ala Ser Asn Ile Thr Gly Leu Leu Lys Thr Arg Asp Gly Gly 
    450                 455                 460                 


Glu Glu Asp Asn Ala Ser Glu Thr Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Val 
                485                 490                 495     


Val Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Arg Arg Val Val Gln 
            500                 505                 510         


Arg Glu Lys Asp Leu Gly Leu Gly Ala Leu Phe Leu Gly Phe Leu Gly 
        515                 520                 525             


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr Leu Thr Val Gln 
    530                 535                 540                 


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu 
545                 550                 555                 560 


Arg Ala Ile Glu Ala Gln His Gln Leu Leu Gln Leu Thr Val Trp Gly 
                565                 570                 575     


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg 
            580                 585                 590         


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
        595                 600                 605             


Thr Thr Ser Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asp 
    610                 615                 620                 


Asp Ile Trp Asn Asn Met Thr Trp Met Gln Trp Glu Lys Glu Ile Glu 
625                 630                 635                 640 


Asn Tyr Thr Val Glu Ile Tyr Lys Leu Ile Gly Glu Ala Gln Asn Gln 
                645                 650                 655     


Gln Glu Lys Asn Glu Lys Asp Leu Leu Glu Leu Asp Asn Trp Ala Ser 
            660                 665                 670         


Leu Trp Asn Trp Phe Ser Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile 
        675                 680                 685             


Phe Ile Met Ile Ile Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala 
    690                 695                 700                 


Val Leu Ser Ile Val Lys Lys Val Arg Gln Gly Tyr Ser Pro Leu Ser 
705                 710                 715                 720 


Leu Gln Thr Arg Leu Pro Thr Gln Arg Gly Pro Asp Arg Pro Glu Gly 
                725                 730                 735     


Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Gly Ser Ser Ile Arg Leu 
            740                 745                 750         


Val Asp Gly Phe Leu Ala Leu Ile Trp Asp Asp Leu Gly Ser Leu Gly 
        755                 760                 765             


Pro Phe Ser Tyr Pro Arg Leu Glu Asp Leu Pro Pro Ile Val Thr Arg 
    770                 775                 780                 


Ile Gly Glu Leu Leu Gly Arg Arg Gly Trp Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Ser Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Lys Ser Ala Val 
                805                 810                 815     


Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg 
            820                 825                 830         


Ile Leu Glu Val Val Gln Arg Phe Cys Arg Ala Ile Leu His Ile Pro 
        835                 840                 845             


Val Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
    850                 855                 860 


<210> 229
<211> 875
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 229
Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln Arg Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Thr Ala Thr Gly Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Asp Thr Glu Ala 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Leu Glu Leu Lys Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Ile Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Gly Leu Arg Asn Asn Thr Asn Ala Thr Ser Ala Ser Ser 
    130                 135                 140                 


Thr His Pro Pro Thr Thr Ser Ser Ser Ser Arg Asn Ile Met Glu Gly 
145                 150                 155                 160 


Glu Met Ala Asn Cys Ser Phe Asn Ile Thr Thr Thr Met Asn Lys Val 
                165                 170                 175     


Gln Lys Glu Tyr Ala Leu Phe Tyr Thr His Asp Val Val Gln Ile Val 
            180                 185                 190         


Asp Asn Asp Asn Asn Asn Ala Ser Asn Ser Ala Lys Lys Arg Ile Ser 
        195                 200                 205             


Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Val Thr Gln Ala Cys Pro 
    210                 215                 220                 


Lys Val Asn Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly 
225                 230                 235                 240 


Phe Ala Ile Leu Lys Cys Asn Glu Lys Glu Phe Ser Gly Lys Gly Pro 
                245                 250                 255     


Cys Lys Asn Val Ser Thr Val Gln Ser Thr His Gly Ile Arg Pro Val 
            260                 265                 270         


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu Ile 
        275                 280                 285             


Val Ile Arg Ser Glu Asn Phe Thr Asp Asn Thr Lys Thr Ile Ile Val 
    290                 295                 300                 


Gln Leu Asn Glu Pro Val Lys Ile Glu Cys Thr Arg Pro Asn Asn Asn 
305                 310                 315                 320 


Thr Arg Glu Ser Ile Thr Met Gly Pro Gly Lys Ala Phe Tyr Ala Thr 
                325                 330                 335     


Gly Asp Ile Ile Gly Asn Ile Arg Lys Ala Tyr Cys Thr Leu Arg Gly 
            340                 345                 350         


Thr Glu Trp Thr Asn Thr Leu Lys Arg Ile Ala Glu Lys Leu Gly Glu 
        355                 360                 365             


Lys Phe Glu Asn Lys Thr Ile Lys Phe Thr Gln Ser Ser Gly Gly Asp 
    370                 375                 380                 


Pro Glu Ile Val Ala His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
385                 390                 395                 400 


Cys Glu Thr Thr Gln Leu Phe Asn Ser Thr Trp Ile Arg Asp Asn Gly 
                405                 410                 415     


Asn Trp Thr Arg Ala Glu Asn Ile Thr Glu Gly Asn Asn Ile Thr Leu 
            420                 425                 430         


Pro Cys Arg Ile Arg Gln Ile Val Asn Leu Trp Gln Gln Val Gly Lys 
        435                 440                 445             


Ala Met Tyr Ala Pro Pro Ile Ser Gly Pro Ile Asn Cys Leu Ser Asn 
    450                 455                 460                 


Ile Thr Gly Leu Leu Leu Thr Trp Asp Gly Gly Asn Asn Ser Thr Ser 
465                 470                 475                 480 


Asn Asn Asn Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
                485                 490                 495     


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro 
            500                 505                 510         


Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu 
        515                 520                 525             


Lys Arg Ala Val Gly Leu Gly Ala Leu Phe Leu Gly Phe Leu Gly Thr 
    530                 535                 540                 


Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr Leu Thr Val Gln Ala 
545                 550                 555                 560 


Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg 
                565                 570                 575     


Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile 
            580                 585                 590         


Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp 
        595                 600                 605             


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr 
    610                 615                 620                 


Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asn Asp 
625                 630                 635                 640 


Ile Trp Asp Asn Met Thr Trp Met Gln Trp Glu Arg Glu Ile Ile Asn 
                645                 650                 655     


Tyr Thr Gly Leu Ile Tyr Thr Leu Leu Val Glu Ser Gln Ile Gln Gln 
            660                 665                 670         


Glu Lys Asn Val Gln Glu Leu Leu Glu Leu Asp Thr Trp Ala Ser Leu 
        675                 680                 685             


Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe 
    690                 695                 700                 


Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Thr Val 
705                 710                 715                 720 


Leu Ser Ile Val Asn Thr Val Thr Gln Gly Tyr Ser Pro Leu Ser Phe 
                725                 730                 735     


Gln Thr Arg Leu Pro Ser Gln Glu Gly Thr Asp Arg Pro Glu Gly Ile 
            740                 745                 750         


Gln Glu Gly Gly Gly Glu Thr Asp Arg Ser Gly Pro Ile Arg Leu Val 
        755                 760                 765             


Asp Gly Phe Leu Ala Phe Ile Trp Val Asp Leu Arg Ser Leu Cys Leu 
    770                 775                 780                 


Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Thr 
785                 790                 795                 800 


Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Leu Leu Asn Tyr Leu Trp 
                805                 810                 815     


Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Leu Asn Thr Ala Gln Arg 
            820                 825                 830         


Leu Phe Asn Thr Thr Ala Ile Val Val Ala Glu Gly Thr Asp Arg Val 
        835                 840                 845             


Ile Glu Val Val Gln Arg Ala Tyr Arg Ala Ile Leu His Ile Pro Thr 
    850                 855                 860                 


Arg Ile Arg Gln Gly Leu Glu Arg Leu Leu Leu 
865                 870                 875 


<210> 230
<211> 832
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 230
Met Arg Val Lys Gly Ile Arg Lys Asn Cys Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Ile Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Val Thr Val Tyr Tyr Gly Val Pro Val Lys Glu Ala Thr Thr Thr 
        35                  40                  45              


Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asn Thr Glu Val His Asn 
    50                  55                  60                  


Val Trp Ala Thr His Ala Cys Val Pro Thr Asn Pro Asn Pro Gln Lys 
65                  70                  75                  80  


Val Val Leu Lys Asn Val Thr Lys Asn Phe Asn Met Lys Asn Asn Met 
                85                  90                  95      


Val Lys Gln Met His Lys Asn Ile Ile Ser Leu Trp Asp Gln Ser Leu 
            100                 105                 110         


Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr 
        115                 120                 125             


Asp Tyr Leu Lys Asn Asn Thr Asn Thr Thr Ser Ser Ser Glu Lys Glu 
    130                 135                 140                 


Met Lys Gly Gly Lys Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Lys 
145                 150                 155                 160 


Ile Glu Asn Lys Val Gln Lys Lys Tyr Ala Leu Phe Tyr Lys Leu Asn 
                165                 170                 175     


Val Val Pro Ile Asn Asn Thr Thr Thr Ser Tyr Arg Leu Ile Ser Cys 
            180                 185                 190         


Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Lys Pro 
        195                 200                 205             


Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Phe Ala Leu Leu Lys Cys 
    210                 215                 220                 


Lys Asn Lys Lys Phe Asn Glu Thr Gly Pro Cys Thr Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Lys Ser Leu Ala Glu Lys Lys Val Val Ile Lys Ser Lys Asn 
            260                 265                 270         


Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Lys Ser Val 
        275                 280                 285             


Lys Ile Asn Cys Thr Lys Pro Asn Asn Asn Thr Arg Lys Ser Ile His 
    290                 295                 300                 


Ile Gly Pro Gly Gln Ala Leu Tyr Ala Thr Glu Ala Ile Ile Glu Asn 
305                 310                 315                 320 


Ile Arg Gln Ala His Cys Asn Ile Ser Lys Ala Lys Asn Asn Thr Leu 
                325                 330                 335     


Lys Gln Ile Val Lys Lys Leu Lys Val Gln Phe Arg Asn Lys Thr Ile 
            340                 345                 350         


Ile Phe Asn Gln Ser Ser Gly Gly Asp Pro Lys Ile Val Met His Ser 
        355                 360                 365             


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Lys Leu Phe 
    370                 375                 380                 


Asn Ser Thr Met Phe Asn Asn Thr Asn Asn Thr Lys Asn Thr Lys Glu 
385                 390                 395                 400 


Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Arg 
                405                 410                 415     


Trp Gln Lys Val Arg Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln 
            420                 425                 430         


Ile Lys Cys Ser Ser Asn Ile Thr Gly Ile Leu Leu Thr Lys Asn Gly 
        435                 440                 445             


Ser Thr Asn Asn Ser Thr Asn Lys Thr Phe Arg Pro Lys Glu Glu Asn 
    450                 455                 460                 


Ile Arg Asn Asn Lys Ser Lys Leu Tyr Lys Tyr Lys Val Val Lys Ile 
465                 470                 475                 480 


Lys Pro Leu Lys Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln 
                485                 490                 495     


Arg Glu Lys Lys Ala Val Glu Thr Lys Ala Leu Phe Leu Gly Phe Leu 
            500                 505                 510         


Arg Ala Ala Gly Ser Thr Met Gly Ala Ala Ala Val Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 
    530                 535                 540                 


Leu Arg Ala Ile Lys Ala Gln Gln His Leu Leu Gln Leu Thr Val Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Ala Lys Val Leu Ala Val Lys Lys Tyr Leu Arg 
                565                 570                 575     


Asn Gln Gln Leu Leu Gly Ile Gly Cys Ser Glu Lys Leu Ile Cys Thr 
            580                 585                 590         


Thr Thr Val Pro Asn Ala Ser Ser Asn Lys Ser Leu Asn Lys Ile Asn 
        595                 600                 605             


Asn Ile Thr Met Lys Lys Lys Lys Ile Asn Asn Tyr Thr Ser Leu Ile 
    610                 615                 620                 


Tyr Ser Leu Ile Lys Lys Ser Gln Asn Gln Gln Val Lys Asn Arg Gln 
625                 630                 635                 640 


Lys Leu Leu Lys Leu Asn Lys Ala Ser Leu Ser Phe Asn Ile Thr Lys 
                645                 650                 655     


Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val Lys Gly Leu Ile 
            660                 665                 670         


Gly Leu Lys Ile Val Phe Leu Val Leu Ser Ile Val Asn Lys Val Arg 
        675                 680                 685             


Gln Lys Tyr Ser Pro Leu Ser Phe Gln Thr Arg Phe Pro Ala Pro Lys 
    690                 695                 700                 


Glu Pro Asp Arg Pro Glu Gly Ile Glu Glu Lys Gly Lys Lys Asp Lys 
705                 710                 715                 720 


Asp Arg Ser Gly Gln Leu Val Asn Lys Phe Leu Thr Leu Ile Ile Asn 
                725                 730                 735     


Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Lys Asn Leu Leu 
            740                 745                 750         


Leu Ile Val Ala Lys Ile Val Lys Leu Leu Lys Arg Arg Gly Trp Glu 
        755                 760                 765             


Ala Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Ser Gln Lys Leu Lys 
    770                 775                 780                 


Asn Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu 
785                 790                 795                 800 


Gly Thr Asp Arg Val Ile Glu Val Val Gln Arg Thr Cys Arg Ala Ile 
                805                 810                 815     


Leu His Ile Pro Ala Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
            820                 825                 830         


<210> 231
<211> 864
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 231
Met Arg Ala Lys Glu Met Arg Lys His Trp Gln Gln Trp Trp Lys Gly 
1               5                   10                  15      


Gly Ile Leu Leu Leu Gly Met Leu Met Ile Cys Ser Thr Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Ala 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Phe Leu Lys Asn Val Thr Glu Asn Phe Asn Met Gly Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Asn Ile Lys Leu Lys Asn Ala Thr Glu Asn Ala Thr 
    130                 135                 140                 


Ala Thr Lys Ala Asn Lys Glu Glu Ile Ile Asn Cys Ser Phe Leu Val 
145                 150                 155                 160 


Thr Thr Asp Arg Lys Asp Lys Glu Gln Asn Glu Tyr Ala Leu Phe Tyr 
                165                 170                 175     


Arg Leu Asp Ile Cys Thr Asn Lys Ser Trp Leu Leu Leu Val Tyr Thr 
            180                 185                 190         


Asn Asn Thr Asp Tyr Arg Leu Asp Ser Cys Asn Thr Ser Val Ile Thr 
        195                 200                 205             


Pro Ser Gly Pro Arg Arg Cys Pro Cys Glu Ser Ile Ser Ile His Pro 
    210                 215                 220                 


Cys Thr Leu Asp Asp Cys Ala Ile Phe Lys Cys Asn Glu Lys Lys Cys 
225                 230                 235                 240 


Asn Gly Thr Gly Val Cys Lys Thr Val Ser Thr Val His Cys Ile His 
                245                 250                 255     


Gly Leu Ser Ala Val Gly Ser Ser Pro Leu Leu Leu Asn Gly Ser Leu 
            260                 265                 270         


Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala 
        275                 280                 285             


Lys Thr Ile Ile Val Gln Leu Lys Glu Ala Val Thr Ile Asn Cys Thr 
    290                 295                 300                 


Arg Pro Asn Asn Asn Thr Arg Lys Gly Ile His Ile Gly Pro Gly Arg 
305                 310                 315                 320 


Ala Phe Tyr Ala Thr Glu Ser Ile Ile Gly Asp Ile Arg Gln Ala His 
                325                 330                 335     


Cys Asn Leu Ser Arg Ala Gln Trp Asn Asn Thr Leu Arg Gln Ile Val 
            340                 345                 350         


Gln Lys Leu Lys Glu Gln Phe Lys Asn Ala Thr Thr Ile Lys Phe Asn 
        355                 360                 365             


Ser Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His Ser Phe Asn Cys 
    370                 375                 380                 


Gly Gly Glu Phe Leu Tyr Cys Asn Thr Ser His Leu Phe Asn Ser Thr 
385                 390                 395                 400 


Trp Met Cys Asn Ser Thr Trp Asn Ser Thr Asn Thr Glu Gly Asn Asn 
                405                 410                 415     


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Val Asn Met Trp Gln 
            420                 425                 430         


Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Lys Gly Gln Ile Lys 
        435                 440                 445             


Cys Leu Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Val 
    450                 455                 460                 


Gly Asp Asp Ser Ser Asn Asp Thr Glu Ile Phe Arg Pro Gly Gly Gly 
465                 470                 475                 480 


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
                485                 490                 495     


Arg Ile Glu Pro Leu Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val 
            500                 505                 510         


Val Gln Arg Glu Lys Arg Ala Val Gly Thr Leu Gly Ala Met Phe Leu 
        515                 520                 525             


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Val Thr 
    530                 535                 540                 


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
545                 550                 555                 560 


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 
                565                 570                 575     


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu 
            580                 585                 590         


Arg Tyr Leu Trp Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
        595                 600                 605             


Lys Leu Ile Cys Pro Thr Thr Val Pro Trp Asn Thr Ser Trp Ser Asn 
    610                 615                 620                 


Lys Asn Tyr Thr Glu Ile Trp Asn Lys Met Thr Trp Met Gln Trp Glu 
625                 630                 635                 640 


Arg Glu Ile Asp Asn Tyr Thr Ser Leu Ile Tyr Ser Leu Ile Glu Glu 
                645                 650                 655     


Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp 
            660                 665                 670         


Lys Trp Asp Ser Leu Trp Ser Trp Phe Ser Ile Thr His Trp Leu Trp 
        675                 680                 685             


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg 
    690                 695                 700                 


Ile Val Phe Thr Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr 
705                 710                 715                 720 


Ser Pro Leu Ser Phe Gln Thr His Leu Pro Ala Gln Arg Gly Pro Asp 
                725                 730                 735     


Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Glu Arg 
            740                 745                 750         


Ser Thr Arg Leu Val His Gly Leu Leu Ala Leu Ile Trp Asp Asp Leu 
        755                 760                 765             


Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu 
    770                 775                 780                 


Ile Val Ala Arg Thr Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala 
785                 790                 795                 800 


Leu Lys Tyr Leu Trp Asn Leu Leu Gln Tyr Trp Ile Gln Glu Leu Lys 
                805                 810                 815     


Lys Ser Ala Ile Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu 
            820                 825                 830         


Gly Thr Asp Arg Ile Ile Glu Ile Ala Gln Arg Ile Phe Arg Ala Phe 
        835                 840                 845             


Leu His Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Gln 
    850                 855                 860                 


<210> 232
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 232
Met Lys Val Thr Gly Ile Arg Arg Asn Tyr Gln Lys Phe Trp Arg Trp 
1               5                   10                  15      


Gly Ala Leu Leu Leu Gly Met Leu Met Ile Ser Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Asn 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Gly Tyr Lys Thr Glu Ala 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Ala Asn Leu Thr Glu Asn Phe Asn Met Trp Glu 
                85                  90                  95      


Ser Asp Met Val Glu Gln Met His Glu Asp Val Ile Asn Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Leu Asn Ile Thr Ser Asn Asn Thr Ser Ser Ser Asn 
    130                 135                 140                 


Thr Ser Ser Ser Asn Thr Ser Ser Ile Thr Gly Gly Gly Glu Met Lys 
145                 150                 155                 160 


Asn Cys Ser Phe Asn Ile Thr Thr Ser Ile Asn Thr Lys Val Lys Asp 
                165                 170                 175     


Tyr Ala Phe Phe Tyr Asn Leu Asp Ile Val Gln Ile Asn Asn Asp Lys 
            180                 185                 190         


Thr Ser Asp Asn Thr Ser Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val 
        195                 200                 205             


Ile Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro Ile Pro Ile His 
    210                 215                 220                 


Tyr Cys Thr Pro Ala Gly Phe Ala Ile Ile Lys Cys Asn Asn Glu Thr 
225                 230                 235                 240 


Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Ile Val Gln Cys Thr 
                245                 250                 255     


His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
            260                 265                 270         


Leu Ala Glu Arg Asp Val Ala Ile Arg Ser Lys Asn Phe Ser Asn Asn 
        275                 280                 285             


Ala Glu Asn Ile Ile Val Gln Leu Asn Glu Ala Val Gln Ile Asn Cys 
    290                 295                 300                 


Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Asn Ile Gly Pro Gly 
305                 310                 315                 320 


Arg Ala Trp Tyr Thr Thr Gly Glu Ile Ile Gly Asn Ile Arg Gln Ala 
                325                 330                 335     


His Cys Asn Ile Ser Gly Ser Lys Trp Asn Asp Thr Leu Lys Gln Val 
            340                 345                 350         


Val Lys Lys Leu Arg Glu Gln Phe Lys Asn Lys Thr Ile Thr Phe Glu 
        355                 360                 365             


Gln Pro Pro Pro Gly Gly Asp Pro Glu Ile Val Met His Asn Phe Asn 
    370                 375                 380                 


Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gln Leu Phe Asn Ser 
385                 390                 395                 400 


Arg Trp Asp Asp Val Asp Glu Asn Glu Thr Ser Thr Ser Asn Gly Thr 
                405                 410                 415     


Thr Gly Asn Asp Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
            420                 425                 430         


Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Ala 
        435                 440                 445             


Gly Leu Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
    450                 455                 460                 


Asp Gly Gly Asn Ile Asn Ala Thr Gly Asn Asn Thr Asn Lys Asn Asn 
465                 470                 475                 480 


Asn Thr Glu Ile Phe Arg Pro Ala Gly Gly Asn Met Lys Asp Asn Trp 
                485                 490                 495     


Arg Ser Glu Leu Tyr Arg Tyr Lys Val Val Lys Val Glu Pro Leu Gly 
            500                 505                 510         


Val Ala Pro Thr Arg Ala Gln Arg Arg Val Val Gln Arg Glu Lys Arg 
        515                 520                 525             


Ala Val Gly Met Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Thr Ala 
    530                 535                 540                 


Gly Ser Thr Met Gly Ala Ala Ser Leu Thr Leu Thr Val Gln Ala Arg 
545                 550                 555                 560 


Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Arg Asn Leu Leu Arg Ala 
                565                 570                 575     


Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys 
            580                 585                 590         


Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 
        595                 600                 605             


Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr 
    610                 615                 620                 


Asn Val Pro Trp Ser Gly Asn Trp Ser Ser Lys Ser Tyr Asn Asp Ile 
625                 630                 635                 640 


Trp Tyr Asn Met Thr Trp Met Gln Trp Glu Lys Glu Ile Glu Asn Tyr 
                645                 650                 655     


Thr Gly Val Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 
            660                 665                 670         


Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 
        675                 680                 685             


Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile 
    690                 695                 700                 


Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu 
705                 710                 715                 720 


Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln 
                725                 730                 735     


Thr His Phe Pro Thr Gln Arg Gly Pro Gly Arg Pro Glu Gly Thr Glu 
            740                 745                 750         


Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser Glu Arg Leu Val Thr 
        755                 760                 765             


Gly Phe Leu Thr Leu Phe Trp Glu Asp Leu Arg Ser Leu Cys Leu Phe 
    770                 775                 780                 


Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Ala Arg Ile Val 
785                 790                 795                 800 


Glu Leu Leu Gly Arg Arg Gly Trp Glu Val Leu Arg Tyr Trp Trp Asn 
                805                 810                 815     


Leu Leu Gln Tyr Trp Ile Gln Glu Leu Lys Asn Ser Ala Ile Ser Leu 
            820                 825                 830         


Leu Asn Ala Ile Ala Ile Ala Val Gly Glu Gly Thr Asp Arg Val Ile 
        835                 840                 845             


Glu Val Ala Gln Arg Ile Tyr Arg Ala Ile Leu Asn Ile Pro Arg Arg 
    850                 855                 860                 


Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
865                 870                 


<210> 233
<211> 865
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 233
Met Arg Val Lys Gly Ile Arg Lys Asn Cys Gln His Ser Trp Lys Trp 
1               5                   10                  15      


Gly Ile Met Leu Leu Gly Met Leu Met Ile Cys Asn Ala Ser Asp Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Gly Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Cys Lys Lys Asp Asn Asp Thr Leu Gln Cys Asp Cys 
    130                 135                 140                 


Asn Asn Glu Arg Leu Ile Ile Ile Leu Ser Leu Val Thr Tyr Thr Trp 
145                 150                 155                 160 


Glu Arg Gly Glu Ile Arg Asn Cys Ser Val Thr Ala Thr Thr Asp Ile 
                165                 170                 175     


Glu Asp Arg Arg Lys Asn Glu Asp Ala Ser Tyr His Asn Arg Gly Ile 
            180                 185                 190         


Ile Gln Ile Asn Asn Ile Asn Asn Thr Tyr Thr Leu Met Leu Ser Ser 
        195                 200                 205             


Cys Thr Thr Ser Ile Ile Ala Gly Pro Cys Pro Ser Val Ser Leu Asp 
    210                 215                 220                 


Pro Ile Pro Asn Cys Tyr Cys Ala Ala Ala Gly Phe Pro Ile Arg Asn 
225                 230                 235                 240 


Gly Asn Asp Asn Asn Val Ala Gly Pro Gly Pro Ser Asp Ile Val Thr 
                245                 250                 255     


Pro Gly Pro Cys Ala Leu Gly Ile Met Pro Val Ala Pro Pro Leu Leu 
            260                 265                 270         


Leu Val Ser Gly Pro Leu Ala Glu Glu Glu Val Ile Thr Thr Ser Asp 
        275                 280                 285             


Ile Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Thr 
    290                 295                 300                 


Val Lys Ile Asn Cys Thr Arg Pro Ser Asn Asn Thr Arg Lys Ser Ile 
305                 310                 315                 320 


Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly 
                325                 330                 335     


Asp Ile Arg Gln Ala His Cys Asn Ile Ser Gln Ala Lys Trp Asn Asn 
            340                 345                 350         


Thr Leu Lys Gln Val Val Val Lys Leu Arg Glu Gln Phe Gly Met Asn 
        355                 360                 365             


Lys Thr Ile Ile Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
    370                 375                 380                 


Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr 
385                 390                 395                 400 


Arg Leu Phe Asn Thr Thr Trp Asn Asn Thr Glu Lys Ser Asn Pro Thr 
                405                 410                 415     


Glu Gly Asn Gly Thr Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile 
            420                 425                 430         


Asn Leu Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg 
        435                 440                 445             


Gly Gln Ile Asn Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Thr 
    450                 455                 460                 


Asp Gly Gly Met Asn Thr Ser Asn Asn Lys Thr Phe Ile Pro Ala Gly 
465                 470                 475                 480 


Gly Asp Met Arg Asp Tyr Trp Arg Ser Gly Val Leu Lys Tyr Asp Val 
                485                 490                 495     


Val Ile Val Glu Pro Leu Gly Ile Ala Pro Thr Thr Asp Met Arg Arg 
            500                 505                 510         


Val Val Gln Ile Gln Lys Arg Ala Glu Leu Leu Arg Ala Leu Leu Leu 
        515                 520                 525             


Val Phe Leu Gly Ala Ala Gly Arg Thr Met Ser Ala Ala Ser Met Thr 
    530                 535                 540                 


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
545                 550                 555                 560 


Asn Asn Leu Leu Gln Ala Ile Glu Ala Gln Gln His Met Leu Lys Leu 
                565                 570                 575     


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 
            580                 585                 590         


Arg Tyr Leu Gln Asp Gln Gln Phe Leu Gly Phe Trp Gly Cys Ser Gly 
        595                 600                 605             


Lys Arg Ile Cys Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn 
    610                 615                 620                 


Lys Ser Leu Asp Glu Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu 
625                 630                 635                 640 


Lys Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Asn Leu Leu Ile Glu 
                645                 650                 655     


Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Ala Leu Asp 
            660                 665                 670         


Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp 
        675                 680                 685             


Tyr Ile Arg Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg 
    690                 695                 700                 


Ile Val Phe Thr Val Leu Ser Ile Val Arg Arg Val Arg Gln Arg Tyr 
705                 710                 715                 720 


Ser Pro Ile Ser Val Gln Thr Pro Arg Ser Ala Ala Gln Arg Gly His 
                725                 730                 735     


Asp Arg Pro Asp Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp 
            740                 745                 750         


Arg Phe Asp Gln Ser Val Asn Gly Phe Leu Thr Ile Ile Trp Val Asp 
        755                 760                 765             


Val Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu 
    770                 775                 780                 


Ser Ile Val Ser Arg Ile Val Glu Leu Met Gly Arg Arg Gly Trp Gly 
785                 790                 795                 800 


Ile Leu Lys Tyr Trp Cys Asn Leu Leu Gln Tyr Arg Ser Gln Glu Leu 
                805                 810                 815     


Lys Lys Ser Ala Val Ser Leu Phe Asn Ala Thr Ala Ile Val Val Ala 
            820                 825                 830         


Glu Gly Thr Asp Arg Val Ile Glu Ala Ile Gln Arg Ala Phe Arg Ala 
        835                 840                 845             


Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Ala Glu Arg Ala Leu 
    850                 855                 860                 


Ile 
865 


<210> 234
<211> 861
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 234
Met Arg Val Lys Gly Ile Lys Glu Glu Leu Ser Ser Ser Trp Trp Lys 
1               5                   10                  15      


Trp Gly Ile Met Leu Leu Gly Met Leu Met Met Ile Cys Ser Ala Leu 
            20                  25                  30          


Asp Gln Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
        35                  40                  45              


Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr 
    50                  55                  60                  


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
65                  70                  75                  80  


Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
                85                  90                  95      


Trp Lys Asn Asn Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu 
            100                 105                 110         


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
        115                 120                 125             


Thr Leu Asn Cys Thr Asp Leu Arg Asn Asn Thr Glu Ser Asn Asp Thr 
    130                 135                 140                 


Thr Ser Gly Met Ile Leu Gly Lys Asp Lys Ile Lys Met Ile Leu Phe 
145                 150                 155                 160 


Asn Cys Ser Phe Asn Ile Thr Thr Ser Arg Arg Asp Lys Trp Gln Gln 
                165                 170                 175     


Glu Tyr Ala Phe Phe Tyr Lys Leu Asp Ile Met Pro Ile Asp Glu Glu 
            180                 185                 190         


Asn Asn Thr Asn Thr Tyr Thr Leu Ile Ser Cys Asn Thr Ser Val Ile 
        195                 200                 205             


Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr 
    210                 215                 220                 


Cys Thr Pro Ala Gly Phe Ala Leu Leu Lys Cys Asn Asp Lys Lys Phe 
225                 230                 235                 240 


Asn Gly Thr Gly Leu Cys Lys Asn Val Ser Thr Val Gln Cys Thr His 
                245                 250                 255     


Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
            260                 265                 270         


Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asp Asn Ile 
        275                 280                 285             


Lys Thr Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr 
    290                 295                 300                 


Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Asn His Arg Gly Pro 
305                 310                 315                 320 


Gly Arg Ala Phe His Thr Thr Gly Glu Ile Ile Gly Asn Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln 
            340                 345                 350         


Ile Val Ala Lys Leu Arg Glu Gln Phe Gly Lys Asn Lys Thr Ile Val 
        355                 360                 365             


Phe Asn His Ser Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe 
    370                 375                 380                 


Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn 
385                 390                 395                 400 


Ser Thr Trp Asn Ile Thr Gly Gly Leu Asn Asn Thr Glu Gly Asn Gly 
                405                 410                 415     


Thr Ile Thr Leu Gln Cys Lys Ile Lys Gln Phe Ile Asn Met Trp His 
            420                 425                 430         


Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Thr 
        435                 440                 445             


Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu 
    450                 455                 460                 


Asn Pro Gly Asn Asp Thr Asp Thr Phe Thr Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Lys Asp Asn Trp Ser Ser Glu Leu Asp Lys Tyr Arg Val Ile Gly Ile 
                485                 490                 495     


Ala Pro Leu Pro Val Ala Pro Thr Lys Ala Lys Thr Arg Leu Leu Gln 
            500                 505                 510         


Arg Asp Lys Arg Ala Val Gly Ile Gly Ser Val Phe Leu Val Phe Leu 
        515                 520                 525             


Val Ala Ala Gly Ser Thr Met Ser Ala Met Ser Met Thr Met Thr Leu 
    530                 535                 540                 


Gln Ala Gln Glu Leu Leu Tyr Val Thr Glu Arg Met Gln Lys Asn Leu 
545                 550                 555                 560 


Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Ala Val Pro Trp Asn Val Ser Trp Ser Asn Lys Ser Leu 
    610                 615                 620                 


Asp Lys Ile Trp Asn Asn Met Thr Trp Arg Glu Trp Glu Arg Glu Ile 
625                 630                 635                 640 


Asp Asn Tyr Thr Gly Leu Ile Tyr Asn Leu Leu Glu Thr Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 
            660                 665                 670         


Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
        675                 680                 685             


Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe 
    690                 695                 700                 


Thr Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Ile 
705                 710                 715                 720 


Ser Leu Gln Thr Pro Arg Pro Ala Gln Arg Gly Leu Asp Arg Pro Glu 
                725                 730                 735     


Ala Trp Asp Glu Lys Ala Gly Glu Lys Cys Arg Gly His Phe His Arg 
            740                 745                 750         


Cys Val Asn Arg Ile Met Ala Ile Phe Gly Ala Ile Cys Gly Ala Phe 
        755                 760                 765             


Cys Ser Ser Ser Phe Ser Cys Asp Pro Leu Gly Phe Tyr Trp Gly Phe 
    770                 775                 780                 


Trp Lys Phe Leu Pro Gly Gly Gly Lys Pro Leu Lys Asn Ala Trp Asn 
785                 790                 795                 800 


Phe Leu Pro Tyr Leu Val Pro Glu Leu Asn Gln Gly Ala Asn Glu Val 
                805                 810                 815     


Phe Asn Cys Pro Val Asn Ala Thr Gly Glu Ser Thr Gly Arg Gly Ile 
            820                 825                 830         


Glu Thr Phe Gln Arg Thr Phe Lys Ser Ile Phe Gln Ile Leu Ser Gln 
        835                 840                 845             


Ile Thr Pro Gly Gln Thr Gly Ala Lys Lys Gly Trp Val 
    850                 855                 860     


<210> 235
<211> 847
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 235
Met Arg Val Gln Glu Asn Trp Gln Asn Leu Trp Lys Gly Gly Ile Trp 
1               5                   10                  15      


Phe Leu Gly Ile Trp Met Ile Cys Ser Ala Val Glu Gln Leu Trp Val 
            20                  25                  30          


Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Thr Thr Thr Leu 
        35                  40                  45              


Phe Cys Ala Ser Asn Ala Lys Ala Tyr Asp Thr Glu Val His Asn Val 
    50                  55                  60                  


Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val 
65                  70                  75                  80  


Val Leu Gln Asn Val Thr Glu Pro Phe Asn Val Trp Lys Asn Gly Met 
                85                  90                  95      


Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu 
            100                 105                 110         


Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu His Cys Thr 
        115                 120                 125             


Asp Leu Lys Glu Thr Ile Lys Glu Glu Lys Gly Lys Met Lys Asn Cys 
    130                 135                 140                 


Ser Phe Asn Thr Thr Thr Ser Ile Arg Asp Lys Thr Gln Thr Ala Tyr 
145                 150                 155                 160 


Ala Leu Phe Ser Thr Leu Asp Leu Val Gln Ile Lys Asp Gly Lys Ile 
                165                 170                 175     


Asn Ala Asn Ser Lys His Ser Tyr Arg Ile Ile His Cys Asn Thr Ser 
            180                 185                 190         


Thr Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile 
        195                 200                 205             


His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys 
    210                 215                 220                 


Gln Phe Asn Gly Thr Gly Glu Cys Arg Asn Val Ser Ser Val Gln Cys 
225                 230                 235                 240 


Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
                245                 250                 255     


Ser Leu Ala Glu Glu Asp Ile Val Ile Arg Ser Glu Asn Leu Thr Asn 
            260                 265                 270         


Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Thr Val Arg Ile Asn 
        275                 280                 285             


Cys Thr Arg Pro Asn Asn Ile Val Ser Arg Arg Ile His Ile Gly Pro 
    290                 295                 300                 


Gly Arg Thr Phe His Ala Thr Lys Ser Ile Thr Gly Ser Ile Lys Gln 
305                 310                 315                 320 


Ala Phe Cys Asn Leu Ser Arg Pro Gln Trp Glu Asp Thr Leu Gly Lys 
                325                 330                 335     


Ile Val Lys Lys Leu Arg Gln Asn Phe Gly Thr Asn Thr Thr Ile Val 
            340                 345                 350         


Phe Asp His Ser Ser Gly Gly Asp Pro Glu Ile Val Lys Asp Arg Ile 
        355                 360                 365             


Asn Cys Gly Gly Lys Phe Phe Tyr Cys Tyr Ser Ile Lys Leu Phe Lys 
    370                 375                 380                 


Ser Thr Trp Asn Met Glu Trp Ser Thr Gln Lys Ala Ser Asn Thr Glu 
385                 390                 395                 400 


Asn Glu Asn Ile Thr Leu Pro Cys Lys Ile Lys Gln Val Ile Asn Met 
                405                 410                 415     


Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Glu Gly Gln 
            420                 425                 430         


Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
        435                 440                 445             


Gly Lys His Asn Ser Ser Asp Thr Asn Lys Thr Glu Ile Phe Arg Pro 
    450                 455                 460                 


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
465                 470                 475                 480 


Lys Val Val Lys Ile Glu Pro Leu Gly Ile Ala Pro Thr Arg Ala Lys 
                485                 490                 495     


Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Leu Gly Ala Met 
            500                 505                 510         


Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser 
        515                 520                 525             


Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Met Ser Gly Ile Val Gln 
    530                 535                 540                 


Gln Gln Asn Asn Leu Leu Arg Ala Val Glu Ala Gln Gln His Met Leu 
545                 550                 555                 560 


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala 
                565                 570                 575     


Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys 
            580                 585                 590         


Ser Gly Arg Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Thr Ser Trp 
        595                 600                 605             


Ser Asn Arg Thr Gln Asp Asp Ile Trp Thr Asn Leu Thr Trp Met Lys 
    610                 615                 620                 


Trp Glu Lys Glu Ile Asp Asn Tyr Thr Asp Val Ile Tyr Arg Leu Leu 
625                 630                 635                 640 


Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 
                645                 650                 655     


Leu Asp Lys Trp Ala Ser Leu Trp Ser Trp Phe Asp Ile Thr Asn Trp 
            660                 665                 670         


Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly 
        675                 680                 685             


Leu Lys Ile Val Phe Thr Val Phe Ser Ile Val Asn Arg Val Arg Gln 
    690                 695                 700                 


Gly Tyr Ser Pro Val Leu Leu Gln Thr His His Pro Gly Arg Arg Gly 
705                 710                 715                 720 


Arg Pro Arg Pro Val Gly Met Glu Glu Glu Val Gly Glu Gly Asp Arg 
                725                 730                 735     


Asp Ser Ser Cys Pro Leu Ala Val Glu Leu Leu Ser Ile Phe Glu Val 
            740                 745                 750         


Val Phe Arg Ile Leu Phe Val Phe Asn Cys Leu Arg Leu Arg Asp Leu 
        755                 760                 765             


Ile Leu Ile Ile Leu Arg Met Val Val Leu Leu Gly Arg Gly Gly Trp 
    770                 775                 780                 


Glu Ile Phe Lys Tyr Trp Ser Arg Val Leu Gln Phe Arg Ile Gln Glu 
785                 790                 795                 800 


Leu Lys Asn Ser Gly Phe Ile Leu Phe Pro Ser Thr Pro Ile Thr Val 
                805                 810                 815     


Glu Glu Glu Thr Asn Gly Ile Thr Glu Pro Phe Arg Ser Pro Cys Asn 
            820                 825                 830         


Pro Ile Val Ile Ile Pro Ile Arg Lys Lys Gln Gly Ser Glu Arg 
        835                 840                 845         


<210> 236
<211> 850
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 236
Met Arg Val Arg Gly Ile Leu Arg Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Ile Thr Ser Ile Val Ser Arg Asn Val Ser Asn Asn 
    130                 135                 140                 


Asp Asn Met Arg Asn Cys Ser Phe Asn Ile Thr Thr Glu Ile Arg Asp 
145                 150                 155                 160 


Lys Glu Lys Lys Glu Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Ile Pro 
                165                 170                 175     


Leu Glu Lys Asn Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
            180                 185                 190         


Ala Val Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile 
        195                 200                 205             


His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys 
    210                 215                 220                 


Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 
225                 230                 235                 240 


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
                245                 250                 255     


Ser Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn Leu Thr Asp 
            260                 265                 270         


Asn Ala Lys Ile Ile Ile Val Gln Leu Lys Asp Pro Val Thr Ile Val 
        275                 280                 285             


Cys Thr Arg Pro Gly Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro 
    290                 295                 300                 


Gly Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asn Ile Arg Gln 
305                 310                 315                 320 


Ala His Cys Asn Ile Ser Lys Glu Asp Trp Asn Lys Thr Leu Gln Gln 
                325                 330                 335     


Val Gly Lys Lys Leu Ala Glu His Phe Pro Asn Lys Thr Ile Glu Phe 
            340                 345                 350         


Lys Glu His Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn 
        355                 360                 365             


Cys Arg Gly Glu Phe Phe Tyr Cys Tyr Thr Ser Thr Leu Phe Asn Ser 
    370                 375                 380                 


Thr Tyr Asn Ala Glu Tyr Asn Ser Asn Ser Thr Asn Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Gly 
                405                 410                 415     


Val Gly Arg Ala Ile Tyr Ala Pro Pro Ile Glu Gly Asn Ile Thr Cys 
            420                 425                 430         


Glu Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Asp 
        435                 440                 445             


Gly Asn Asn Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
    450                 455                 460                 


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro 
465                 470                 475                 480 


Leu Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu 
                485                 490                 495     


Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala 
            500                 505                 510         


Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala 
        515                 520                 525             


Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg 
    530                 535                 540                 


Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile 
545                 550                 555                 560 


Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp 
                565                 570                 575     


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr 
            580                 585                 590         


Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Ser Gln Asp Asp 
        595                 600                 605             


Ile Trp Gln Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn 
    610                 615                 620                 


Tyr Thr Asn Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln 
625                 630                 635                 640 


Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu 
                645                 650                 655     


Trp Ser Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe 
            660                 665                 670         


Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val 
        675                 680                 685             


Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe 
    690                 695                 700                 


Gln Thr Leu Ile Pro Asn Pro Arg Gly Pro Asp Arg Leu Arg Arg Ile 
705                 710                 715                 720 


Glu Glu Glu Gly Gly Glu Gln Asp Lys Asp Ser Ser Ile Arg Leu Val 
                725                 730                 735     


Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu 
            740                 745                 750         


Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Val Val Arg Ala 
        755                 760                 765             


Val Glu Leu Leu Gly His Ser Ser Leu Arg Gly Leu Gln Arg Gly Trp 
    770                 775                 780                 


Glu Ala Leu Lys Tyr Leu Trp Ser Leu Val Gln Tyr Trp Gly Leu Glu 
785                 790                 795                 800 


Leu Lys Lys Ser Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile Ala Val 
                805                 810                 815     


Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Val Gln Arg Ile Phe Arg 
            820                 825                 830         


Ala Ile Cys Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Ala Ala 
        835                 840                 845             


Leu Gln 
    850 


<210> 237
<211> 883
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 237
Met Arg Val Arg Gly Thr Leu Arg Asn Cys Gln Gln Trp Trp Met Trp 
1               5                   10                  15      


Gly Val Leu Gly Phe Trp Met Leu Met Ile Cys Asn Gly Gly Lys Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Ser Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Glu Cys Arg Asp Val Thr Asn Gly Thr Ser Gly Asn Asp Thr Leu Ala 
    130                 135                 140                 


Asn Asp Thr Ser Glu Cys Lys Asn Gly Thr Asn Asn Glu Thr Tyr Asp 
145                 150                 155                 160 


Glu Ser Val Lys Glu Leu Arg Asn Cys Ser Phe Asn Ala Thr Thr Leu 
                165                 170                 175     


Val Arg Asp Lys Lys Lys Thr Ala Tyr Ala Leu Phe Tyr Arg Leu Asp 
            180                 185                 190         


Ile Met Pro Leu Asn Glu Lys Lys Asn Ser Ser Glu Asn Ser Ser Glu 
        195                 200                 205             


Tyr Val Leu Ile Asn Cys Asn Ser Ser Ala Ile Thr Gln Ala Cys Pro 
    210                 215                 220                 


Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly 
225                 230                 235                 240 


Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro 
                245                 250                 255     


Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val 
            260                 265                 270         


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile 
        275                 280                 285             


Ile Val Arg Ser Glu Asn Leu Thr Asn Asn Val Lys Thr Ile Ile Val 
    290                 295                 300                 


His Leu Asn Gln Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn 
305                 310                 315                 320 


Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr 
                325                 330                 335     


Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys Ile Ile Asn Ala 
            340                 345                 350         


Ser Asn Trp His Lys Thr Leu Gln Glu Val Ser Lys Glu Leu Ala Gly 
        355                 360                 365             


Tyr Phe Pro Asn Lys Thr Ile Ile Phe Asn Ser Ser Ser Gly Gly Asp 
    370                 375                 380                 


Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr 
385                 390                 395                 400 


Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Tyr Met Thr Asn Gly Thr 
                405                 410                 415     


Tyr Met Phe Asn Gly Thr Tyr Arg Leu Asn Asn Ile Thr Ser Asn Ser 
            420                 425                 430         


Asn Ile Thr Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn Thr Trp Gln 
        435                 440                 445             


Glu Val Gly Arg Ala Met Tyr Ala Asn Pro Ile Ala Gly Asn Ile Thr 
    450                 455                 460                 


Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Val Arg Asp Gly Gly Thr 
465                 470                 475                 480 


Asn Asn Ala Thr Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Arg 
                485                 490                 495     


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys 
            500                 505                 510         


Pro Leu Gly Ile Ala Pro Thr Glu Ala Lys Arg Arg Val Val Glu Arg 
        515                 520                 525             


Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
    530                 535                 540                 


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
545                 550                 555                 560 


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
                565                 570                 575     


Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
            580                 585                 590         


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
        595                 600                 605             


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
    610                 615                 620                 


Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser His Glu 
625                 630                 635                 640 


Glu Ile Trp Asn Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser 
                645                 650                 655     


Asn Tyr Thr Asn Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln 
            660                 665                 670         


Gln Glu Arg Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn 
        675                 680                 685             


Leu Trp Ser Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile 
    690                 695                 700                 


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala 
705                 710                 715                 720 


Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Pro 
                725                 730                 735     


Phe Gln Ile Arg Thr Pro Asn Pro Gly Gly Pro Asp Arg Leu Gly Arg 
            740                 745                 750         


Ile Glu Glu Glu Gly Gly Glu Gln Asp Lys Asp Arg Ser Ile Arg Leu 
        755                 760                 765             


Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys 
    770                 775                 780                 


Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Val Ala Ala Arg 
785                 790                 795                 800 


Val Val Glu Leu Leu Gly Arg Ser Ser Leu Arg Gly Leu Gln Lys Gly 
                805                 810                 815     


Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly Leu 
            820                 825                 830         


Glu Leu Lys Lys Ser Ala Thr Ser Leu Leu Asp Thr Ile Ala Ile Ala 
        835                 840                 845             


Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Gly Leu Ser Ile Cys 
    850                 855                 860                 


Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Ala 
865                 870                 875                 880 


Ala Leu Gln 
            


<210> 238
<211> 863
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 238
Met Arg Val Arg Gly Ile Pro Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Ile Ile Met Met Cys Arg Val Met Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Glu Leu Lys Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Val Lys Lys Ala Asn Asn Thr Thr Asn Ile Gly Asn 
    130                 135                 140                 


Thr Thr Ser Asn Arg Asn Thr Thr Tyr Asn Ala Thr Tyr Asn Glu Tyr 
145                 150                 155                 160 


Met Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Ile Arg Asp Lys Lys 
                165                 170                 175     


Arg Lys Glu Tyr Ala Leu Phe Tyr Arg Pro Asp Ile Val Pro Leu Glu 
            180                 185                 190         


Asn Ser Ser Ser Glu Tyr Ile Leu Ile Asn Cys Asn Ser Ser Thr Ile 
        195                 200                 205             


Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr 
    210                 215                 220                 


Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe 
225                 230                 235                 240 


Asn Gly Thr Gly Pro Arg His Asn Val Ser Thr Val Gln Cys Thr His 
                245                 250                 255     


Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
            260                 265                 270         


Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Thr 
        275                 280                 285             


Lys Thr Ile Ile Val His Leu Asn Lys Ser Val Ala Ile Asn Cys Thr 
    290                 295                 300                 


Arg Pro Gly Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly Gln 
305                 310                 315                 320 


Ala Ile Tyr Thr Asn Asn Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys 
                325                 330                 335     


Ser Ile Ser Lys Glu Lys Trp Asn Lys Thr Leu Glu Gln Val Lys Glu 
            340                 345                 350         


Lys Leu Lys Glu Tyr Tyr Lys Lys Thr Ile Glu Phe Gln Gln Pro Val 
        355                 360                 365             


Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asp Thr Thr Lys Leu Phe Ser Pro Lys Asn Glu Thr 
385                 390                 395                 400 


Asp Asn Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn 
                405                 410                 415     


Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly 
            420                 425                 430         


Asn Ile Thr Cys Asn Ser Asn Ile Thr Gly Ile Leu Leu Thr Arg Asp 
        435                 440                 445             


Gly Gly Asp Thr His Glu Lys Lys Arg Lys His Lys Arg Asn Lys Val 
    450                 455                 460                 


Thr Glu Ile Phe Arg Pro Ala Gly Gly Asn Met Lys Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Gly Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Met Ala Thr Met Leu Phe Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Val Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Val Leu Ala Ile Glu Arg Phe Leu Gln Gly Gln Gln Leu 
            580                 585                 590         


Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val 
        595                 600                 605             


Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Glu Glu Asp Ile Trp Gly 
    610                 615                 620                 


Asn Leu Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp 
625                 630                 635                 640 


Ile Ile Tyr Arg Leu Leu Glu Asp Ser Gln Thr Gln Gln Glu Gln Asn 
                645                 650                 655     


Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Ser Trp 
            660                 665                 670         


Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Ile Ile 
        675                 680                 685             


Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Gly Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu 
705                 710                 715                 720 


Thr Pro Asn Pro Arg Glu Leu Asp Arg Leu Gly Arg Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Gln Gly Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe 
            740                 745                 750         


Leu Thr Ile Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Leu Tyr 
        755                 760                 765             


His Gln Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Ala Ala Glu Leu 
    770                 775                 780                 


Leu Gly Arg Ser Ser Leu Arg Gly Leu Gln Arg Gly Trp Glu Ala Leu 
785                 790                 795                 800 


Lys Tyr Leu Gly Asn Ile Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys 
                805                 810                 815     


Ser Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile Ala Val Ala Glu Gly 
            820                 825                 830         


Thr Asp Arg Ile Ile Arg Val Ile Gln Ser Ile Cys Arg Ala Ile Arg 
        835                 840                 845             


Asn Ala Pro Arg Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu Leu 
    850                 855                 860             


<210> 239
<211> 856
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 239
Met Arg Val Arg Gly Thr Leu Arg Asn Tyr Gln Gln Trp Trp Thr Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Ile Ile Tyr Ser Val Ala Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Thr Asn Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro His Pro 
65                  70                  75                  80  


Gln Glu Leu Val Leu Ala Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Asn Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Arg Cys Thr Lys Val Asn Gly Thr Ala Asn Ala Thr Ser Glu Gly Thr 
    130                 135                 140                 


Ala Asn Ala Thr Ser Lys Asp Glu Glu Met Thr Met Tyr Asn Cys Ser 
145                 150                 155                 160 


Phe Asn Thr Thr Thr Gly Ile Arg Asp Lys Thr Gln Gln Glu Tyr Ala 
                165                 170                 175     


Leu Phe His Lys His Asp Val Val Pro Ser Asn Ile Asp Asn Ser Glu 
            180                 185                 190         


Tyr Ile Leu Ile His Cys Asn Thr Ser Thr Ile Thr Gln Ala Cys Pro 
        195                 200                 205             


Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly 
    210                 215                 220                 


Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro 
225                 230                 235                 240 


Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val 
                245                 250                 255     


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu Ile 
            260                 265                 270         


Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Ser Lys Thr Ile Ile Val 
        275                 280                 285             


His Leu Asn Glu Ser Val Asp Ile Val Cys Thr Arg Pro Gly Asn Asn 
    290                 295                 300                 


Thr Arg Arg Gly Ile Arg Ile Gly Pro Gly Gln Thr Phe Phe Ala Thr 
305                 310                 315                 320 


Arg Thr Ile Gly Asn Ile Arg Gln Ala His Cys Asn Ile Ser Glu Ser 
                325                 330                 335     


Lys Trp Asn Thr Thr Leu Gln Arg Val Ser Ala Lys Leu Lys Glu Tyr 
            340                 345                 350         


Phe Asn Lys Thr Ile Ile Tyr Asn Ser Ser Ser Gly Gly Asp Pro Glu 
        355                 360                 365             


Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Ser Arg Leu Phe Asn Arg Asn Ser Thr Asp Leu Ser Thr Asn Thr 
385                 390                 395                 400 


Gly Asn Asn Ser Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
                405                 410                 415     


Asn Met Trp Gln Gly Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Glu 
            420                 425                 430         


Gly Asn Ile Thr Cys Lys Ser Ile Ile Thr Gly Leu Leu Leu Val Arg 
        435                 440                 445             


Asp Gly Gly Pro Asn Asn Ser Thr Glu Thr Arg Pro Glu Pro Gly Arg 
    450                 455                 460                 


Glu Gly Asn Met Lys Gly Asn Lys Phe Gly Arg Lys Ser Glu Ile Ile 
465                 470                 475                 480 


Ile Lys Tyr Lys Val Ile Glu Asn Leu Ser Pro Leu Gly Glu Ile His 
                485                 490                 495     


Pro Thr Lys Ala Lys Arg Arg Ala Val Glu Arg Glu Lys Arg Ala Val 
            500                 505                 510         


Val Gly Ile Gly Ala Met Ile Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val His Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Arg Leu 
            580                 585                 590         


Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ser Val 
        595                 600                 605             


Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Glu Ala Asp Ile Trp Asn 
    610                 615                 620                 


Asn Met Thr Trp Met Gln Trp Glu Lys Glu Ile Asn Asn Tyr Thr Tyr 
625                 630                 635                 640 


Thr Ile Tyr Gln Leu Leu Glu Asp Ser Gln Ser Gln Gln Glu Gln Asn 
                645                 650                 655     


Glu Lys Asp Leu Leu Glu Leu Asp Lys Trp Gln Asn Leu Trp Ser Trp 
            660                 665                 670         


Phe Ser Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu 
705                 710                 715                 720 


Thr Pro Ser Pro Arg Glu Leu Asp Arg Arg Glu Arg Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Gln Asp Arg Asp Arg Ser Val Arg Leu Val Ser Gly Phe 
            740                 745                 750         


Leu Ser Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ile Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Phe Ile Leu Ile Ala Thr Arg Val Val Glu Leu 
    770                 775                 780                 


Leu Gly Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu Gly Asn Leu Val 
785                 790                 795                 800 


Leu Tyr Trp Gly Leu Glu Ile Lys Lys Ser Ala Ile Asn Leu Leu Asp 
                805                 810                 815     


Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Val 
            820                 825                 830         


Val His Arg Ala Cys Arg Ala Ile Arg Tyr Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Asp Phe Glu Ala Asp Leu Gln 
    850                 855     


<210> 240
<211> 854
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 240
Met Arg Val Arg Gly Ile Arg Arg Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Val Leu Gly Phe Trp Ile Leu Met Ile Cys Asn Gly Gly Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asp Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asn Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Glu Cys Arg Asn Val Ser Thr Cys Asn Glu Thr Tyr Asn Glu Ser Val 
    130                 135                 140                 


Lys Glu Ile Lys Asn Cys Ser Phe Asn Ala Thr Thr Glu Ile Arg Asp 
145                 150                 155                 160 


Arg Lys Gln Thr Val Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro 
                165                 170                 175     


Leu Asp Lys Lys Asn Ser Ser Arg Asn Ser Ser Asp Tyr Tyr Arg Leu 
            180                 185                 190         


Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Thr 
        195                 200                 205             


Phe Asp Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Tyr Ala Ile 
    210                 215                 220                 


Leu Lys Cys Asn Asp Lys Thr Phe Asn Gly Thr Gly Pro Cys His Asn 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Arg Glu Ile Ile Ile Arg 
            260                 265                 270         


Ser Glu Asn Leu Thr Asp Asn Val Lys Thr Ile Ile Val His Leu Asn 
        275                 280                 285             


Glu Ser Val Asp Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys 
    290                 295                 300                 


Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile 
305                 310                 315                 320 


Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Glu Asp Lys Trp 
                325                 330                 335     


Asn Glu Thr Leu Gln Arg Val Ser Lys Asn Leu Ala Glu His Phe Pro 
            340                 345                 350         


Asn Lys Thr Ile Lys Phe Ala Ser Ser Ser Gly Gly Asp Leu Glu Ile 
        355                 360                 365             


Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr 
    370                 375                 380                 


Ser Gly Leu Phe Asn Gly Thr Tyr Met Ser Asn Gly Thr Glu Ser Asn 
385                 390                 395                 400 


Ser Ser Ser Ile Ile Thr Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn 
                405                 410                 415     


Met Trp Gln Glu Val Gly Arg Thr Met Tyr Ala Pro Pro Ile Lys Gly 
            420                 425                 430         


Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Val Arg Asp 
        435                 440                 445             


Gly Gly Thr Glu Pro Asn Asp Thr Glu Thr Phe Arg Pro Gly Gly Gly 
    450                 455                 460                 


Asp Met Arg Asn Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
465                 470                 475                 480 


Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Ala Ala Lys Arg Arg Val 
                485                 490                 495     


Val Glu Arg Glu Lys Arg Ala Val Gly Leu Gly Ala Val Phe Leu Gly 
            500                 505                 510         


Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu 
        515                 520                 525             


Thr Ala Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser 
    530                 535                 540                 


Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr 
545                 550                 555                 560 


Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg 
                565                 570                 575     


Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys 
            580                 585                 590         


Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Arg 
        595                 600                 605             


Ser Glu Lys Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg 
    610                 615                 620                 


Glu Ile Ser Asn Tyr Thr Asn Thr Ile Tyr Arg Leu Leu Glu Asp Ser 
625                 630                 635                 640 


Gln Asn Gln Gln Glu Arg Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser 
                645                 650                 655     


Trp Lys Asn Leu Trp Ser Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr 
            660                 665                 670         


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile 
        675                 680                 685             


Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser 
    690                 695                 700                 


Pro Leu Ser Phe Gln Thr Leu Thr Pro Asn Ser Gly Gly Pro Asp Arg 
705                 710                 715                 720 


Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Lys Asp Arg Ser 
                725                 730                 735     


Ile Arg Leu Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg 
            740                 745                 750         


Asn Leu Cys Leu Phe Ser Tyr His Arg Leu Lys Asp Cys Ile Leu Val 
        755                 760                 765             


Thr Ala Arg Val Val Glu Leu Leu Gly Arg Asn Ser Leu Arg Gly Leu 
    770                 775                 780                 


Gln Lys Gly Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr 
785                 790                 795                 800 


Trp Gly Leu Glu Leu Lys Lys Ser Thr Thr Ser Leu Leu Asp Thr Leu 
                805                 810                 815     


Thr Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Gly Gln 
            820                 825                 830         


Ser Ile Cys Arg Ala Ile Arg Asn Ile Pro Arg Arg Ile Arg Gln Gly 
        835                 840                 845             


Leu Glu Ala Ala Leu Gln 
    850                 


<210> 241
<211> 883
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 241
Met Arg Val Met Glu Ile Leu Arg Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Gly Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Glu Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Lys Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Glu Cys Gly Asn Val Ser Val Ser Asn Val Ser Val Ser Asn Thr Thr 
    130                 135                 140                 


Gln Gly Asp Ala Asn Val Thr His Asn Glu Gly Ala Asn Glu Ile Lys 
145                 150                 155                 160 


Asn Cys Ser Phe Lys Ile Ala Thr Glu Leu Arg Asp Lys Glu Gln Lys 
                165                 170                 175     


Val Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Gln Leu Asn Asp Ser 
            180                 185                 190         


Ser Asn Ser Ser Ser Ser Asn Asn Ser Ser Lys Tyr Ser Lys Tyr Arg 
        195                 200                 205             


Leu Ile Asn Cys Asp Thr Ser Thr Val Thr Gln Ala Cys Pro Lys Val 
    210                 215                 220                 


Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala 
225                 230                 235                 240 


Ile Leu Lys Cys Asn Asn Glu Thr Phe Asn Gly Thr Gly Pro Cys Thr 
                245                 250                 255     


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser 
            260                 265                 270         


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Lys Gly Gly Val Ile Ile 
        275                 280                 285             


Arg Ser Glu Asn Leu Thr Glu Asn Ala Lys Ile Ile Ile Val His Leu 
    290                 295                 300                 


Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
305                 310                 315                 320 


Lys Ser Val Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Glu 
                325                 330                 335     


Ile Ile Gly Asp Ile Arg Lys Ala Tyr Cys Glu Ile Asn Glu Gln Lys 
            340                 345                 350         


Trp Asn Lys Thr Leu Arg Glu Val Ala Lys Ser Leu Ala Lys His Phe 
        355                 360                 365             


Pro Asn Arg Glu Ile Arg Phe Ala Pro Ser Ser Gly Gly Asp Leu Glu 
    370                 375                 380                 


Ile Val Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn 
385                 390                 395                 400 


Thr Ser Gly Leu Phe Asn Arg Thr Tyr Thr Thr Asp Leu Phe Asn Lys 
                405                 410                 415     


Thr Tyr Asn Asp Asn Asp Thr Glu Asp Asn Ser Gly Pro Val Ile Ile 
            420                 425                 430         


Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
        435                 440                 445             


Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Asn Ser 
    450                 455                 460                 


Ser Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asp Asn Lys 
465                 470                 475                 480 


Thr Ser Thr Asn Glu Thr Phe Arg Pro Leu Gly Gly Asn Met Arg Asp 
                485                 490                 495     


Asn Trp Arg Asn Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro 
            500                 505                 510         


Leu Gly Ile Ala Pro Thr Thr Ala Lys Arg Arg Val Val Glu Arg Glu 
        515                 520                 525             


Lys Arg Ala Val Gly Met Met Gly Ala Met Phe Leu Gly Phe Leu Gly 
    530                 535                 540                 


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
545                 550                 555                 560 


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
                565                 570                 575     


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
            580                 585                 590         


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
        595                 600                 605             


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
    610                 615                 620                 


Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Tyr Asp 
625                 630                 635                 640 


Glu Ile Trp Glu Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Asn 
                645                 650                 655     


Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Ile Gln 
            660                 665                 670         


Gln Glu Arg Asn Glu Lys Asp Leu Leu Ala Leu Asp Asn Trp Lys Asn 
        675                 680                 685             


Leu Trp Asn Trp Phe Asn Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile 
    690                 695                 700                 


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala 
705                 710                 715                 720 


Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
                725                 730                 735     


Phe Gln Thr Leu Ile Pro Ser Pro Gly Gly Pro Asp Arg Leu Glu Arg 
            740                 745                 750         


Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu 
        755                 760                 765             


Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Asn Leu Cys 
    770                 775                 780                 


Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Val Thr Ala Arg 
785                 790                 795                 800 


Ala Val Glu Leu Leu Gly His His Ser Leu Arg Gly Leu Arg Lys Gly 
                805                 810                 815     


Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly Leu 
            820                 825                 830         


Glu Leu Lys Lys Gly Ala Ile Ser Leu Phe Asp Thr Ile Ala Ile Ala 
        835                 840                 845             


Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Phe Leu Gln Arg Leu Cys 
    850                 855                 860                 


Arg Ala Ile Tyr Asn Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Ala 
865                 870                 875                 880 


Ala Leu Gln 
            


<210> 242
<211> 854
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 242
Met Arg Val Lys Gly Ile Gln Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Ile Ile Ile Cys Arg Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Thr Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Ile Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Val Lys Val Asn Ala Thr Ser Asn Gly Thr Thr Thr 
    130                 135                 140                 


Tyr Asn Asn Ser Ile Asp Ser Met Asn Gly Glu Ile Lys Asn Cys Ser 
145                 150                 155                 160 


Phe Asn Ile Thr Thr Glu Ile Arg Asp Lys Lys Gln Lys Val Tyr Ala 
                165                 170                 175     


Leu Phe Tyr Arg Pro Asp Val Val Pro Leu Asn Glu Asn Ser Ser Ser 
            180                 185                 190         


Tyr Ile Leu Ile Asn Cys Asn Thr Ser Thr Thr Thr Gln Ala Cys Pro 
        195                 200                 205             


Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly 
    210                 215                 220                 


Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro 
225                 230                 235                 240 


Cys His Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val 
                245                 250                 255     


Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile 
            260                 265                 270         


Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val 
        275                 280                 285             


His Leu Asn Glu Ser Ile Glu Ile Val Cys Thr Arg Pro Asn Asn Asn 
    290                 295                 300                 


Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Val Tyr Ala Thr 
305                 310                 315                 320 


Asn Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Lys 
                325                 330                 335     


Thr Lys Trp Asn Thr Thr Leu Glu Lys Val Lys Glu Lys Leu Lys Glu 
            340                 345                 350         


His Phe Pro Ser Lys Ala Ile Thr Phe Gln Pro His Ser Gly Gly Asp 
        355                 360                 365             


Leu Glu Val Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asp Thr Thr Lys Leu Phe Asn Glu Ser Asn Leu Asn Thr Thr Asn 
385                 390                 395                 400 


Thr Thr Thr Leu Thr Leu Pro Cys Arg Ile Lys Gln Ile Val Asn Met 
                405                 410                 415     


Trp Gln Gly Val Gly Arg Ala Met Tyr Ala Pro Pro Val Glu Gly Asn 
            420                 425                 430         


Ile Thr Cys Asn Ser Ser Ile Thr Gly Leu Leu Leu Val Arg Asp Gly 
        435                 440                 445             


Gly Asn Thr Ser Asn Ser Thr Pro Glu Ile Phe Arg Pro Gly Gly Gly 
    450                 455                 460                 


Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
465                 470                 475                 480 


Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val 
                485                 490                 495     


Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Leu Phe Gly 
            500                 505                 510         


Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu 
        515                 520                 525             


Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser 
    530                 535                 540                 


Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr 
545                 550                 555                 560 


Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg 
                565                 570                 575     


Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys 
            580                 585                 590         


Leu Ile Cys Pro Thr Thr Val Pro Trp Asn Ser Ser Trp Ser Asn Lys 
        595                 600                 605             


Ser Gln Thr Asp Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg 
    610                 615                 620                 


Glu Ile Ser Asn Tyr Thr Gly Thr Ile Tyr Lys Leu Leu Glu Glu Ser 
625                 630                 635                 640 


Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser 
                645                 650                 655     


Trp Lys Asn Leu Trp Ser Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr 
            660                 665                 670         


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile 
        675                 680                 685             


Ile Phe Gly Val Leu Ser Ile Val Lys Arg Val Arg Gln Gly Tyr Ser 
    690                 695                 700                 


Pro Leu Ser Phe Gln Thr Leu Thr Pro Asn Pro Arg Gly Leu Asp Arg 
705                 710                 715                 720 


Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Lys Asp Arg Ser 
                725                 730                 735     


Ile Arg Leu Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg 
            740                 745                 750         


Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Val 
        755                 760                 765             


Ala Ala Arg Ala Val Glu Leu Leu Gly Arg Ser Ser Leu Arg Gly Leu 
    770                 775                 780                 


Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu Gly Asn Leu Val Gln Tyr 
785                 790                 795                 800 


Gly Gly Leu Glu Leu Lys Arg Arg Ala Ile Ser Leu Phe Asp Thr Ile 
                805                 810                 815     


Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Leu Glu Val Ile Leu 
            820                 825                 830         


Arg Ile Ile Arg Ala Ile Arg Asn Ile Pro Thr Arg Ile Arg Gln Gly 
        835                 840                 845             


Phe Glu Ala Ala Leu Leu 
    850                 


<210> 243
<211> 867
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 243
Met Lys Val Arg Gly Thr Gln Arg Asn Tyr Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Glu Arg Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Gln Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Arg Ser Met Glu Asn Val Thr Glu Asn Phe Asn Met Trp Glu 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Ala Lys Val Asn Ile Thr Ala Asp Asn Ser Lys Thr 
    130                 135                 140                 


Tyr Asn Glu Ser Met Lys Glu Ile Lys Asn Cys Ser Phe Asn Ala Thr 
145                 150                 155                 160 


Thr Val Ile Lys Asp Lys Lys Gln Thr Val Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Ile Val Pro Leu Asp Asn Glu Glu Gln Glu Asn Asn Gly Asn 
            180                 185                 190         


Glu Asn Tyr Thr Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Thr Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Ser Asn Val Ser Thr Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Glu Glu Glu Ile Ile Ile Arg Ser Lys Asn Leu Ser Gln Asn His Arg 
        275                 280                 285             


Thr Ile Ile Val His Leu Asn Glu Ser Val Gly Ile Glu Cys Thr Arg 
    290                 295                 300                 


Pro Ser Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr 
305                 310                 315                 320 


Phe Phe Ala Thr Gly Glu Ile Ile Gly Asn Ile Arg Gln Ala His Cys 
                325                 330                 335     


Asn Ile Ser Lys Glu Lys Trp Asp Lys Thr Leu Gln Met Val Gly Lys 
            340                 345                 350         


Lys Leu Ala Glu His Phe Pro Asn Lys Thr Ile Ile Phe Ala Pro Ala 
        355                 360                 365             


Ser Gly Gly Asp Leu Glu Ile Thr Met His Ser Phe Asn Cys Arg Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asp Thr Lys Lys Leu Phe Asn Ala Thr Tyr Met 
385                 390                 395                 400 


Asn Asp Asp Thr Ala Asn Asn Ser Arg Ser Asn Gly Asn Asp Thr Val 
                405                 410                 415     


Thr Leu Pro Cys Lys Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val 
            420                 425                 430         


Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys 
        435                 440                 445             


Ser Asn Ile Thr Gly Leu Leu Leu Val Arg Asp Gly Gly Lys Met Asn 
    450                 455                 460                 


Gln Asn Ile Glu Thr Asn Lys Thr Glu Thr Phe Arg Pro Glu Gly Gly 
465                 470                 475                 480 


Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
                485                 490                 495     


Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val 
            500                 505                 510         


Val Glu Arg Glu Lys Arg Ala Val Gly Leu Gly Ala Val Phe Leu Gly 
        515                 520                 525             


Phe Leu Gly Val Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu 
    530                 535                 540                 


Thr Ala Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser 
545                 550                 555                 560 


Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr 
                565                 570                 575     


Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Ile Leu Ala Ile Glu Arg 
            580                 585                 590         


Phe Leu Gln Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys 
        595                 600                 605             


Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Asn Thr Trp Ser Asn Lys 
    610                 615                 620                 


Ser Glu Ser Glu Ile Trp Asn Asn Met Thr Trp Met Gln Trp Asp Arg 
625                 630                 635                 640 


Glu Ile Ser Asn Tyr Thr Phe Thr Ile Tyr Gln Leu Leu Glu Asp Ser 
                645                 650                 655     


Gln Ile Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser 
            660                 665                 670         


Trp Asn Ser Leu Trp Ser Trp Phe Asn Ile Thr Ser Trp Leu Trp Tyr 
        675                 680                 685             


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile 
    690                 695                 700                 


Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser 
705                 710                 715                 720 


Pro Leu Ser Leu Gln Thr Leu Ile Pro Thr Pro Arg Glu Pro Asp Arg 
                725                 730                 735     


Pro Arg Gly Ile Glu Glu Gly Gly Gly Glu Gln Asp Asn Ala Thr Ser 
            740                 745                 750         


Ile Arg Leu Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg 
        755                 760                 765             


Asn Leu Cys Leu Phe Ser Tyr Arg His Leu Arg Asp Leu Leu Ser Val 
    770                 775                 780                 


Ile Ala Arg Val Val Gly Leu Leu Gly Arg Val Gly Gly Gly Gly Leu 
785                 790                 795                 800 


Gln Arg Gly Gly Lys Ala Pro Lys Leu Gly Gly Leu Gly Ala Tyr Trp 
                805                 810                 815     


Gly Leu Glu Ile Lys Lys Ser Val Phe Ser Cys Leu Ile Arg Leu Ala 
            820                 825                 830         


Ile Ala Val Leu Lys Gly Thr Val Arg Phe Leu Lys Leu Val Gln Asp 
        835                 840                 845             


Phe Gly Lys Gly Ile Asn Asn Tyr Pro Arg Arg Ile Pro Gly Phe Glu 
    850                 855                 860                 


Thr Gly Leu 
865         


<210> 244
<211> 864
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 244
Met Arg Val Met Gly Thr Leu Arg Ser Cys Gln Arg Trp Trp Ile Gly 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Phe Met Cys Ser Val Gly Glu Asp 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Arg Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Ile Leu Lys Asn Val Thr Glu Asn Phe Asn Ile Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Gly Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Ser Ser Ser Val Ala Asn Ser Thr Asn Ser 
    130                 135                 140                 


Thr Asn Ser Gly Asn Ile Thr Asn Ala Asn Thr Thr Asn Val Asn Ile 
145                 150                 155                 160 


Thr Asp Ser Asp Met Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Leu 
                165                 170                 175     


Arg Asp Lys Thr Arg Lys Glu Tyr Ala Leu Phe Tyr Arg Pro Asp Ile 
            180                 185                 190         


Val Pro Leu Ser Asn Ser Asn Ser Ser Glu Tyr Ile Leu Ile Asn Cys 
        195                 200                 205             


Asn Ser Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro 
    210                 215                 220                 


Ile Pro Leu His Tyr Cys Ala Pro Ala Gly Tyr Ala Leu Leu Lys Cys 
225                 230                 235                 240 


Arg Asp Thr Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr 
                245                 250                 255     


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
            260                 265                 270         


Leu Asn Gly Ser Leu Ala Glu Asp Glu Ile Val Ile Arg Ser Glu Asn 
        275                 280                 285             


Ile Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Lys Glu Pro Val 
    290                 295                 300                 


Thr Ile Met Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Met Arg 
305                 310                 315                 320 


Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Ala Ile Ile Gly Asn 
                325                 330                 335     


Ile Arg Gln Ala His Cys Asn Ile Ser Arg Thr Asn Trp Thr Lys Thr 
            340                 345                 350         


Leu Gln Glu Val Gly Glu Lys Leu Gln Glu Gln Glu Leu Phe Lys Asn 
        355                 360                 365             


Lys Thr Ile Lys Phe Thr Glu His Ser Gly Gly Asp Ile Glu Ile Thr 
    370                 375                 380                 


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
385                 390                 395                 400 


Glu Leu Phe Asn Gly Thr Tyr Ser Asn Gly Thr Tyr Thr Pro Asn Asn 
                405                 410                 415     


Asn Gly Ser Asp Ser Asn Leu Thr Ile Thr Ile Pro Cys Arg Ile Lys 
            420                 425                 430         


Gln Val Val Asn Leu Trp Gln Gly Val Gly Gln Ala Met Asp Ala Pro 
        435                 440                 445             


Pro Ile Ala Gly Ile Ser Trp Gly Ser Ile Arg Gly Leu Leu Leu Pro 
    450                 455                 460                 


Gly Gly Gly Pro Asn Pro Ser Thr Ala Glu Ile Phe Arg Pro Gly Gly 
465                 470                 475                 480 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
                485                 490                 495     


Val Glu Val Asn Pro Leu Gly Ile Ala Pro Thr Arg Ala Lys Arg Arg 
            500                 505                 510         


Val Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu 
        515                 520                 525             


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Val Thr 
    530                 535                 540                 


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
545                 550                 555                 560 


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu 
                565                 570                 575     


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Leu Glu 
            580                 585                 590         


Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
        595                 600                 605             


Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn 
    610                 615                 620                 


Lys Ser Tyr Asp Ala Ile Trp Asp Asn Met Thr Trp Met Gln Trp Glu 
625                 630                 635                 640 


Lys Glu Ile Asp Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Val 
                645                 650                 655     


Ser Gln Thr Gln Gln Glu Gln Asn Glu Arg Asp Leu Leu Ala Leu Asp 
            660                 665                 670         


Lys Trp Asn Asn Leu Trp Ser Trp Phe Asn Ile Ser Asn Trp Leu Trp 
        675                 680                 685             


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
    690                 695                 700                 


Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr 
705                 710                 715                 720 


Ser Pro Leu Ser Leu Gln Thr Leu Ile Pro Ser Pro Arg Gly Pro Asp 
                725                 730                 735     


Arg Pro Gly Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Ser Ser 
            740                 745                 750         


Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu 
        755                 760                 765             


Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Val Leu 
    770                 775                 780                 


Ile Ala Ala Arg Gly Val Asn Leu Leu Gly Gln Arg Gly Trp Glu Ala 
785                 790                 795                 800 


Leu Lys Leu Leu Trp Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys 
                805                 810                 815     


Lys Ser Ala Ile Ser Leu Phe Asp Thr Leu Ala Ile Thr Val Ala Glu 
            820                 825                 830         


Gly Thr Asp Arg Ile Ile Glu Ile Val Gln Arg Thr Trp Arg Ala Ile 
        835                 840                 845             


Cys Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu Gln 
    850                 855                 860                 


<210> 245
<211> 826
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 245
Met Ser Val Lys Asp Ile Leu Glu Asn Tyr Gln His Trp Trp Ile Trp 
1               5                   10                  15      


Gly Leu Leu Ala Phe Trp Met Gln Met Val Cys Met Gly Asp Asn Leu 
            20                  25                  30          


Trp Val Met Val Tyr Tyr Gly Ala Pro Val Trp Arg Glu Ala Lys Pro 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Gly Tyr Asn Lys Glu Ser Gln 
    50                  55                  60                  


Ser Val Trp Ala Thr Cys Ala Cys Val Pro Thr Asp Pro Pro Pro Gln 
65                  70                  75                  80  


Glu Leu Val Leu Gly Ile Val Thr Glu Tyr Phe Asn Val Trp Lys Met 
                85                  90                  95      


Asp Gly Ile His Cys Glu Gly Tyr Asn Leu Leu Gly Tyr Gln Pro Lys 
            100                 105                 110         


Pro Val Cys Lys Gly Asn Ile Cys Val Leu Lys Leu Tyr Ile Cys Tyr 
        115                 120                 125             


Cys Tyr Gln Gln Phe Trp Leu Val Gly Glu Met Lys Asn Cys Thr Leu 
    130                 135                 140                 


Asn Ala Thr Thr Glu Leu Arg Asp Asn Arg Lys Lys Glu Ser Ala Leu 
145                 150                 155                 160 


Phe Tyr Arg Leu Asp Val Leu Pro Leu Asn Ser Ser Asp Asn Asn Asn 
                165                 170                 175     


Asn Glu Tyr Arg Leu Ile Asn Cys Ser Thr Ser Ala Ile Thr Gln Ala 
            180                 185                 190         


Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro 
        195                 200                 205             


Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asp Arg Thr Phe Asn Gly Thr 
    210                 215                 220                 


Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys 
225                 230                 235                 240 


Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Thr Lys Glu 
                245                 250                 255     


Ile Ile Ile Ser Ser Glu Asn Leu Thr Lys Asn Thr Lys Thr Ile Ile 
            260                 265                 270         


Val His Leu Asn Glu Ser Val Gly Ile Val Cys Ile Arg Pro Asn Asn 
        275                 280                 285             


Asn Thr Arg Lys Ser Val Arg Ile Gly Pro Gly Gln Thr Phe Phe Ala 
    290                 295                 300                 


Thr Gly Ala Ile Ile Gly Glu Ile Arg Gln Ala Tyr Cys Thr Val Asn 
305                 310                 315                 320 


Gly Ser Ala Trp Asn Asn Thr Leu Gln Arg Val Arg Lys Lys Leu Arg 
                325                 330                 335     


Arg Tyr Phe Ser Lys Ala Ile Arg Phe Glu Pro Ser Ser Gly Gly Asp 
            340                 345                 350         


Leu Leu Leu Thr Thr His Ser Phe Thr Cys Arg Gly Gly Tyr Phe Tyr 
        355                 360                 365             


Cys Asn Thr Ser Asn Leu Ile Asn Asn Asn Ile Asn Ile Ala Ser Ala 
    370                 375                 380                 


Ser Thr Ile Gln Arg Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Gly 
385                 390                 395                 400 


Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys 
                405                 410                 415     


Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Glu Asn 
            420                 425                 430         


Asn Arg Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Lys Asp Asn 
        435                 440                 445             


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ser Lys Pro Leu 
    450                 455                 460                 


Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys 
465                 470                 475                 480 


Arg Ala Val Gly Leu Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala 
                485                 490                 495     


Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg 
            500                 505                 510         


Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Lys Ala 
        515                 520                 525             


Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys 
    530                 535                 540                 


Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu Glu Asp Gln 
545                 550                 555                 560 


Gln Leu Leu Gly Met Trp Gly Cys Ser Gly Arg Arg Ile Cys Thr Thr 
                565                 570                 575     


Ala Leu Ser Trp Asn Ser Ser Trp Ser Asn Lys Thr Tyr Asp Asp Ile 
            580                 585                 590         


Trp Asn Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr 
        595                 600                 605             


Thr Asp Thr Ile Phe Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu 
    610                 615                 620                 


Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp 
625                 630                 635                 640 


Ser Trp Phe Asn Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile 
                645                 650                 655     


Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu 
            660                 665                 670         


Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Val Ser Leu Gln 
        675                 680                 685             


Thr Leu Ile Pro Ala Pro Arg Gly Pro Asp Arg Pro Gly Gly Ile Glu 
    690                 695                 700                 


Glu Gly Gly Gly Glu Gln Asp Lys Asp Arg Ser Ile Arg Leu Leu Asn 
705                 710                 715                 720 


Gly Phe Leu Thr Leu Val Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe 
                725                 730                 735     


Ser Asn His Arg Leu Arg Asp Phe Ile Leu Gln Ser Gln Arg Ala Val 
            740                 745                 750         


Glu Val Val Gly Arg Arg Gly Trp Glu Ala Lys Lys Tyr Ala Gly Gly 
        755                 760                 765             


Gly Leu Gln Tyr Trp Gly Glu Glu Leu Lys Gln Ser Gly Phe Ser Ser 
    770                 775                 780                 


Asn Asp Thr Ile Ala Ile Val Val Glu Glu Gly Thr Asp Arg Ile Ile 
785                 790                 795                 800 


Gln Val Leu Gln Trp Ile Gly Arg Ala Ser Asn Asn Ile Pro Gly Arg 
                805                 810                 815     


Ile Arg Gln Gly Phe Glu Val Ala Gly Gln 
            820                 825     


<210> 246
<211> 839
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 246
Met Arg Val Met Gly Met Gln Arg Asn Cys Gln Lys Trp Trp Val Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Phe Met Ile Tyr Asn Val Met Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn 
        35                  40                  45              


Pro Thr Leu Phe Cys Ala Ser Asp Ala Lys Gly Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Leu Phe Leu Glu Asn Ile Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Glu Met Val Glu Gln Met His Gln Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Arg Cys Ser Asn Val Thr Tyr Asn Glu Thr Ile Arg Glu Met Thr Asn 
    130                 135                 140                 


Cys Ser Phe Asn Val Thr Thr Glu Leu Arg Asp Arg Arg Gln Glu Val 
145                 150                 155                 160 


Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Ser Leu Asn Lys Ser Gly 
                165                 170                 175     


Asp Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr Ile Thr Gln Ala Cys 
            180                 185                 190         


Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
        195                 200                 205             


Gly Tyr Ala Ile Leu Lys Cys Asn Asp Glu Glu Phe Asn Gly Thr Gly 
    210                 215                 220                 


Pro Cys Gly Asn Val Ser Thr Val Gln Cys Ser His Gly Ile Lys Pro 
225                 230                 235                 240 


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Asn Val 
                245                 250                 255     


Thr Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val 
            260                 265                 270         


Gln Leu Arg Glu Pro Val Tyr Ile Asn Cys Thr Arg Pro Asn Asn Asn 
        275                 280                 285             


Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Ala Leu Tyr Ala Thr 
    290                 295                 300                 


Gly Glu Val Ile Gly Asp Ile Arg His Ala His Cys Asn Ile Ser Lys 
305                 310                 315                 320 


Glu Lys Trp Lys Thr Ala Leu Thr Gly Val Arg Glu Arg Leu Arg Glu 
                325                 330                 335     


Leu Phe Asn Arg Thr Ile Leu Phe Asn Lys Ser Ser Gly Gly Asp Leu 
            340                 345                 350         


Glu Val Thr Thr His Ser Ser Asn Cys Arg Gly Glu Phe Val Tyr Cys 
        355                 360                 365             


Asp Thr Ser Asp Leu Leu Thr Thr Ser Val Ser Val Gln Lys Val Leu 
    370                 375                 380                 


Val Ile Thr Ser Thr Asp Ala Ile Ile Leu Arg Cys Gln Ile Gln His 
385                 390                 395                 400 


Ile Ile Ser Met Trp Gln Val Arg Arg Ala Leu Tyr Ala Pro Pro Met 
                405                 410                 415     


Lys Gly Met Arg Ser Ser Thr Cys Thr Ile Thr Gly Thr Thr Asp Leu 
            420                 425                 430         


Arg Asp Gly Arg Thr Asp Tyr His Ser Met Tyr Ile Val Arg Pro Gly 
        435                 440                 445             


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
    450                 455                 460                 


Val Val Glu Val Lys Pro Ile Gly Ile Ala Pro Thr Gly Ala Lys Arg 
465                 470                 475                 480 


Arg Val Val Glu Arg Glu Lys Arg Ala Ala Leu Gly Ala Val Phe Leu 
                485                 490                 495     


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Val Thr 
            500                 505                 510         


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
        515                 520                 525             


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu 
    530                 535                 540                 


Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Leu Glu 
545                 550                 555                 560 


Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
                565                 570                 575     


Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Gly Ser Trp Ser Asn 
            580                 585                 590         


Arg Ser Gln Gln Glu Ile Trp Glu Asn Met Thr Trp Met Gln Trp Glu 
        595                 600                 605             


Arg Glu Ile Asp Asn Tyr Thr Asn Ile Ile Tyr Glu Leu Leu Glu Val 
    610                 615                 620                 


Ser Gln Asn Gln Gln Glu Thr Asn Glu Arg Asp Leu Leu Ala Leu Asp 
625                 630                 635                 640 


Lys Trp Asn Asn Leu Trp Ser Trp Phe Asn Ile Ser Asn Trp Leu Trp 
                645                 650                 655     


Tyr Ile Arg Leu Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
            660                 665                 670         


Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr 
        675                 680                 685             


Ser Pro Leu Ser Phe Gln Thr Leu Ile Pro Asn Pro Arg Gly Pro Asp 
    690                 695                 700                 


Arg Pro Gly Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg 
705                 710                 715                 720 


Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu 
                725                 730                 735     


Arg Ser Leu Cys Leu Phe Ser Leu Leu His Leu Arg Asp Leu Ile Glu 
            740                 745                 750         


Ile Val Ala Arg Ala Val Glu Leu Val Glu His Ser Ser Leu Arg Gly 
        755                 760                 765             


Leu Gln Arg Gly Trp Asp Thr Leu Asn Tyr Leu Arg Ser Leu Val Gln 
    770                 775                 780                 


Tyr Arg Ser Lys Glu Ile Lys Lys Ser Ala Thr Asn Met Leu Asp Thr 
785                 790                 795                 800 


Thr Ala Ile Ala Val Asp Glu Val Thr Asp Ser Ile Ile Gly Phe Ala 
                805                 810                 815     


Gln Arg Ile Trp Arg Gly Ile Cys Asn Ile Arg Ala Arg Ile Arg Gln 
            820                 825                 830         


Gly Tyr Glu Ala Gly Gly Gln 
        835                 


<210> 247
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 247
Met Arg Val Arg Gly Ile Leu Arg Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Phe Met Ile Cys Asn Gly Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Glu Ala Lys Ser Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Gln Val Leu Asp Asn Val Thr Glu Asn Phe Asn Met Trp Glu 
                85                  90                  95      


Asn Asp Met Val Glu Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Ile Asn Ile Thr Gly Gly Gly Ala Glu Cys Met Ala 
    130                 135                 140                 


Ser Asn Glu Arg Ile Arg Glu Val Arg Asn Cys Ser Phe Asn Ala Thr 
145                 150                 155                 160 


Thr Glu Ile Arg Asp Lys Lys Gln Lys Val Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Ile Val Ser Leu Tyr Asn Leu Asp Ile Val Ala Ile Gln Ala 
            180                 185                 190         


Ser Ser Gly His Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Val Pro Ala Gly Tyr Ala Ile Leu Lys Gly Asn Asn Lys Thr Phe Lys 
225                 230                 235                 240 


Gly Pro Gly His Gly Asn Lys Val Ser Thr Val Gln Thr His Gly Ile 
                245                 250                 255     


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Ile Ile Ile Arg Ser Lys Asn Leu Ser Asp Ser Thr Lys Ile 
        275                 280                 285             


Ile Ile Val Gln Phe Asn Gln Ser Val Lys Ile Val Cys Ala Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Val Phe 
305                 310                 315                 320 


Tyr Ala Thr Gly Asp Ile Leu Gly Asp Ile Arg Gln Ala His Cys Asn 
                325                 330                 335     


Ile Ser Lys Asn Lys Trp Lys Asp Thr Leu His Asn Val Ser Lys Ile 
            340                 345                 350         


Leu Ala Glu Gln Phe Ser Ile Lys Thr Ile Ile Phe Thr Ser Ser Ser 
        355                 360                 365             


Ser Ser Thr Leu Asn Phe Asn Arg His Ser Phe Asn Cys Arg Gly Ala 
    370                 375                 380                 


Phe Leu Tyr Cys Asn Ser Cys Tyr Leu Phe Asn Arg Leu Tyr Thr Ala 
385                 390                 395                 400 


Ala Asn Thr Lys Ser Asn Ser Trp Ile Asp Ile Asn Cys Thr Val Ala 
                405                 410                 415     


Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
            420                 425                 430         


Arg Ala Met Tyr Ala Asn Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser 
        435                 440                 445             


Asp Ile Thr Gly Met Leu Leu Glu Arg Asp Cys Gly Lys Glu Arg Asp 
    450                 455                 460                 


Lys Thr Ile Ser Thr Thr Lys Glu Ile Phe Arg Pro Ile Gly Gly Asn 
465                 470                 475                 480 


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu 
                485                 490                 495     


Ile Lys Pro Leu Gly Val Ala Pro Thr Glu Ala Lys Arg Arg Val Val 
            500                 505                 510         


Glu Arg Glu Lys Arg Val Ala Gly Leu Gly Ala Val Phe Leu Gly Phe 
        515                 520                 525             


Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr 
    530                 535                 540                 


Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn 
545                 550                 555                 560 


Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val 
                565                 570                 575     


Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr 
            580                 585                 590         


Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu 
        595                 600                 605             


Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Asn Trp Ser Ser Lys Ser 
    610                 615                 620                 


Gln Thr Glu Ile Trp Asn His Thr Thr Trp Met Gln Trp Asp Arg Glu 
625                 630                 635                 640 


Ile Asn Asn Tyr Thr Asn Thr Ile Tyr Gln Leu Leu Glu Asp Ser Gln 
                645                 650                 655     


Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Arg Trp 
            660                 665                 670         


Lys Asn Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile 
        675                 680                 685             


Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile 
    690                 695                 700                 


Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro 
705                 710                 715                 720 


Leu Ser Phe Gln Thr Leu Thr Pro Asn Pro Arg Glu Leu Asp Arg Leu 
                725                 730                 735     


Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile 
            740                 745                 750         


Arg Leu Val Asn Gly Phe Phe Ser Leu Ala Trp Asp Asp Leu Arg Ser 
        755                 760                 765             


Leu Cys Leu Phe Cys Tyr His Arg Leu Thr Asp Leu Ile Ser Val Thr 
    770                 775                 780                 


Ala Arg Ala Val Glu Leu Leu Gly Arg Ser Ser Leu Arg Gly Leu Gln 
785                 790                 795                 800 


Arg Gly Trp Lys Val Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp 
                805                 810                 815     


Gly Leu Glu Leu Lys Lys Ser Ala Ile Arg Leu Leu Asp Ile Thr Ala 
            820                 825                 830         


Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Phe Phe Gln Arg 
        835                 840                 845             


Leu Cys Arg Ala Ile Cys Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe 
    850                 855                 860                 


Glu Ala Ala Leu Gln 
865                 


<210> 248
<211> 837
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 248
His Gln Trp Trp Ile Trp Gly Ile Leu Gly Phe Trp Met Ile Tyr Asn 
1               5                   10                  15      


Val Val Gly Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp 
            20                  25                  30          


Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr 
        35                  40                  45              


Glu Lys Glu Ala His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr 
    50                  55                  60                  


Asp Pro Asn Pro Leu Glu Ile Val Met Gly Asn Val Thr Glu Asn Phe 
65                  70                  75                  80  


Asn Met Trp Asp Asn Ser Met Val Glu Gln Met His Glu Asp Ile Ile 
                85                  90                  95      


Ser Leu Trp Asp Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu 
            100                 105                 110         


Cys Val Thr Leu Glu Cys Asp Asn Val Thr Tyr Thr Gly Asn Glu Asp 
        115                 120                 125             


Ser Ile Thr Glu Lys Glu Met Lys Asn Cys Ser Phe Asn Ala Thr Thr 
    130                 135                 140                 


Glu Ile Glu Asp Lys Lys Arg Lys Glu Arg Val Leu Phe His Ser Leu 
145                 150                 155                 160 


Asp Ile Val Pro Leu Glu Asn Asn Asn Ser Ser Asn Asn Gly Ser Ser 
                165                 170                 175     


Asn Lys Lys Tyr Arg Leu Ile Asn Cys Asp Thr Ser Thr Thr Thr Gln 
            180                 185                 190         


Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
        195                 200                 205             


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Glu Thr Phe Asn Gly 
    210                 215                 220                 


Thr Gly Pro Cys His Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
225                 230                 235                 240 


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                245                 250                 255     


Lys Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Glu Asn Ala Lys Ile 
            260                 265                 270         


Ile Ile Val His Leu Asn Glu Ser Ile Glu Ile Met Cys Ile Arg Pro 
        275                 280                 285             


Gly Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro Gly Gln Thr Phe 
    290                 295                 300                 


Tyr Ala Asn Asp Ile Ile Gly Asp Ile Arg Lys Ala His Cys Lys Val 
305                 310                 315                 320 


Asn Arg Ser Lys Trp Asn Glu Thr Leu Gln Lys Val Gly Ile Lys Leu 
                325                 330                 335     


Lys Glu His Phe Asn Lys Thr Ile Ile Phe Glu Ser Ser Ser Gly Gly 
            340                 345                 350         


Asp Pro Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe 
        355                 360                 365             


Tyr Cys Asn Thr Ser Gly Leu Phe Asn Gly Thr Phe Asn Gly Thr Tyr 
    370                 375                 380                 


Thr Asn Ser Thr Gln Asn Glu Thr Thr Ile Thr Leu Pro Cys Arg Ile 
385                 390                 395                 400 


Lys Gln Ile Ile Asn Met Trp Gln Gly Val Gly Arg Ala Met Tyr Ala 
                405                 410                 415     


Pro Pro Ile Ala Gly Asn Ile Thr Cys Thr Ser Asn Ile Thr Gly Leu 
            420                 425                 430         


Leu Leu Leu Arg Asp Gly Gly Asn Thr Thr Asn Ser Lys Glu Glu Glu 
        435                 440                 445             


Ile Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu 
    450                 455                 460                 


Leu Tyr Lys Tyr Lys Val Val Glu Val Lys Pro Leu Gly Val Ala Pro 
465                 470                 475                 480 


Thr Gly Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Ile 
                485                 490                 495     


Gly Ala Val Val Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
            500                 505                 510         


Ala Ala Ser Ile Ala Leu Thr Ala Gln Ala Arg Lys Val Leu Ser Gly 
        515                 520                 525             


Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 
    530                 535                 540                 


His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 
545                 550                 555                 560 


Val Leu Ala Val Glu Arg Tyr Leu Gln Asp Gln Gln Leu Leu Gly Ile 
                565                 570                 575     


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn 
            580                 585                 590         


Ser Ser Trp Ser Asn Lys Ser Leu Asp Asp Ile Trp Gly Asn Met Thr 
        595                 600                 605             


Trp Met Gln Trp Asp Lys Glu Val Ser Asn Tyr Thr His Thr Ile Tyr 
    610                 615                 620                 


Ser Leu Leu Glu Glu Ser Gln Ile Gln Gln Glu Arg Asn Glu Lys Glu 
625                 630                 635                 640 


Leu Leu Ala Leu Asp Lys Trp Gln Ser Leu Trp Asn Trp Phe Asp Ile 
                645                 650                 655     


Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly 
            660                 665                 670         


Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg 
        675                 680                 685             


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Thr 
    690                 695                 700                 


Ser Arg Gly Pro Glu Arg Leu Gly Gly Ile Glu Glu Glu Gly Gly Glu 
705                 710                 715                 720 


Gln Gly Lys Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Thr Ile 
                725                 730                 735     


Val Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Leu Leu 
            740                 745                 750         


Arg Asp Phe Val Leu Ile Val Ala Arg Gly Val Glu Leu Leu Gly Arg 
        755                 760                 765             


Arg Gly Trp Glu Thr Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp 
    770                 775                 780                 


Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu Leu Asp Thr Ile Glu 
785                 790                 795                 800 


Ile Ile Val Ala Glu Gly Thr Asp Arg Ile Ile Asn Phe Leu Gln Ser 
                805                 810                 815     


Ile Cys Arg Ala Ile Arg Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe 
            820                 825                 830         


Glu Ala Ala Leu Leu 
        835         


<210> 249
<211> 852
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 249
Met Arg Val Arg Gly Ile Gln Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Ile Ile Leu Ser Cys Arg Gly Val Gly Asp 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala His Val Arg Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Asn Leu Trp Asp 
            100                 105                 110         


Gln Gly Leu Lys Pro Cys Val Lys Ile Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Arg Cys Thr Asn Ala Thr Phe Thr Ala Asn Asp Ser Asn Asp Asn Asn 
    130                 135                 140                 


Val Thr Met Ser Glu Trp Thr Glu Met Thr Thr Cys Ser Phe Ser Asn 
145                 150                 155                 160 


Thr Thr Gln Ile Gly Asp Ala Leu Gln Thr Ala Tyr Ala Leu Leu Tyr 
                165                 170                 175     


Leu Thr Asp Ser Lys Pro Leu Phe Glu Arg Cys Tyr Thr Ser Ile His 
            180                 185                 190         


Leu Pro Tyr Leu Thr His Gly Thr Leu Gly Asp Pro Lys Ala Ser Cys 
        195                 200                 205             


Tyr Arg Ala Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Arg 
    210                 215                 220                 


Lys Cys Asn Asp Arg Thr Phe Asn Gly Thr Gly Pro Cys Asn Arg Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Met Ile Arg Ser 
            260                 265                 270         


Glu Asn Leu Thr Asp Asn Thr Lys Thr Ile Ile Val Gln Leu Lys Glu 
        275                 280                 285             


Pro Val Glu Ile Asn Cys Thr Arg Pro Gly Lys Gly Lys Arg Thr Arg 
    290                 295                 300                 


Val Arg Ile Gly Pro Gly Arg Thr Phe Tyr Ala Thr Gly Ala Val Thr 
305                 310                 315                 320 


Gly Asp Ile Arg Lys Ala His Cys Thr Val Asn Gly Ser Arg Trp Asn 
                325                 330                 335     


Ser Thr Leu Glu Gln Val Arg Glu Lys Leu Lys Lys Tyr Tyr Asp Asn 
            340                 345                 350         


Arg Thr Ile Lys Phe Glu Gln Pro Ser Gly Gly Asp Pro Glu Val Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asp Thr Thr 
    370                 375                 380                 


Asn Leu Phe Asn Ile Ser Asn Ile Asn Ser Thr Ser Asn Ile Thr Leu 
385                 390                 395                 400 


Gln Cys Lys Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Arg 
                405                 410                 415     


Ala Met Tyr Ala Pro Pro Ile Glu Gly Thr Ile Thr Cys Ile Ser Asn 
            420                 425                 430         


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Ser Ser Asn Glu Thr 
        435                 440                 445             


Ser Ser Ile Asn Lys Thr Glu Ile Phe Arg Pro Gly Gly Gly Asn Met 
    450                 455                 460                 


Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile 
465                 470                 475                 480 


Lys Pro Leu Gly Ile Ala Pro Thr Gly Ala Lys Arg Arg Val Val Glu 
                485                 490                 495     


Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
            500                 505                 510         


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
    530                 535                 540                 


Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Leu Glu Arg Tyr Leu 
                565                 570                 575     


Thr Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Arg 
        595                 600                 605             


Ala Asp Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile 
    610                 615                 620                 


Asn Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Glu Ser Gln Thr 
625                 630                 635                 640 


Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys 
                645                 650                 655     


Asn Leu Trp Asn Trp Phe Asn Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
            660                 665                 670         


Ile Phe Ile Met Val Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Leu 
        675                 680                 685             


Gly Val Leu Ser Ile Val Lys Arg Val Arg Gln Gly Tyr Ser Pro Leu 
    690                 695                 700                 


Ser Phe Gln Thr Leu Ile Pro Asn Pro Arg Asp Pro Asp Arg Leu Gly 
705                 710                 715                 720 


Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg 
                725                 730                 735     


Leu Val Ser Gly Phe Leu Ser Leu Ala Trp Asp Asp Leu Arg Ser Leu 
            740                 745                 750         


Cys Leu Phe Ser Tyr His Gln Leu Arg Ser Phe Ile Leu Val Thr Ala 
        755                 760                 765             


Arg Ala Val Gln Leu Leu Gly Arg Ser Ser Leu Arg Gly Leu Gln Gly 
    770                 775                 780                 


Gly Trp Glu Ala Leu Lys Tyr Leu Gly Asn Leu Val Gln Tyr Trp Gly 
785                 790                 795                 800 


Leu Glu Leu Lys Arg Ser Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile 
                805                 810                 815     


Thr Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Ile Gln Gly Ile 
            820                 825                 830         


Cys Arg Ala Ile Cys Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu 
        835                 840                 845             


Arg Ala Leu Leu 
    850         


<210> 250
<211> 814
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 250
Met Arg Val Met Gly Thr Ser Arg Asn Cys Gln Gln Gly Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Phe Met Ile Cys Asn Val Leu Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Leu Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Gln Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asp Ala Thr Ile Asn Gly Thr Ile Val Glu Lys Met Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Val Thr Ser Thr Leu Lys Pro Thr Lys Leu Lys 
145                 150                 155                 160 


Ala Tyr Ala Leu Ile Tyr Arg Thr Glu Leu Val Pro Leu Ile Glu Asn 
                165                 170                 175     


Gln Ile Asn Gly Asn Tyr Met Ile Thr Gly Tyr Leu Asn Asn Leu Asn 
            180                 185                 190         


Ile Thr Lys Ser Gly Gln Thr Val Ser Phe Gly Pro Phe Arg Pro His 
        195                 200                 205             


Pro Trp Pro His Ala Gly Gln Ala Ser Leu Thr Val Lys Cys Asn Asn 
    210                 215                 220                 


Ile Ser Phe Lys Gly Thr Gly Pro Cys Asn Lys Val Ser Ser Val Gln 
225                 230                 235                 240 


Cys Thr Gln Gly Ile Lys Leu Val Glu Trp Thr Arg Leu Met Leu Tyr 
                245                 250                 255     


Gly Ser Ile Ala Glu Glu Gln Ile Glu Ile Arg Cys Glu Asn Leu Thr 
            260                 265                 270         


Ile Lys Thr Gly Leu Ile Ile Val Gln Leu Lys Glu Ser Val Ala Ile 
        275                 280                 285             


Arg Cys Glu Arg Pro Lys Asn Asn Thr Arg Gly Ser Met Arg Val Gly 
    290                 295                 300                 


Pro Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg 
305                 310                 315                 320 


Gln Asp His Ser Asn Ile Ser Glu Lys Glu Trp Asn Glu Thr Lys Gln 
                325                 330                 335     


Lys Val Val Glu Lys Leu Ile Glu Leu Leu Pro Thr Thr Arg Lys Leu 
            340                 345                 350         


Thr Arg Ser Ser Gly Gly Asp Pro Glu Ile Thr Thr His Ser Phe Asn 
        355                 360                 365             


Cys Arg Gly Glu Phe Phe Tyr Cys Asp Thr Thr Asn Leu Phe Asn Ser 
    370                 375                 380                 


Thr Tyr Asn Gly Thr Ser Thr Asn Ser Thr Ser Ser Gly Thr Ile Thr 
385                 390                 395                 400 


Leu Ser Cys Ser Ile Lys Gln Ile Ile Gln Met Trp Gln Gly Leu Arg 
                405                 410                 415     


Lys Val Leu Asn Ala Pro Val Cys Ala Pro Leu Asp Gly Asn Ile Lys 
            420                 425                 430         


Cys Thr Ser Asn Phe Thr Gly Leu Leu Leu Pro Arg Ala Gly Gly Ser 
        435                 440                 445             


Gly Leu Asn Asp Thr Asp Ala Glu Val Phe Arg Pro Ala Gly Gly Asp 
    450                 455                 460                 


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu 
465                 470                 475                 480 


Ile Lys Pro Leu Gly Val Ala Pro Thr Thr Ala Lys Arg Arg Val Val 
                485                 490                 495     


Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe 
            500                 505                 510         


Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr 
        515                 520                 525             


Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn 
    530                 535                 540                 


Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val 
545                 550                 555                 560 


Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Val Glu Arg Tyr 
                565                 570                 575     


Leu Gln Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu 
            580                 585                 590         


Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Thr 
        595                 600                 605             


Gln Asp Glu Ile Trp Asn Asn Met Thr Trp Met Gln Trp Glu Lys Glu 
    610                 615                 620                 


Ile Asn Asn Tyr Thr Gly Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln 
625                 630                 635                 640 


Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Lys Trp 
                645                 650                 655     


Gln Asn Leu Trp Ser Trp Phe Ser Ile Ser Lys Trp Leu Trp Tyr Ile 
            660                 665                 670         


Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile 
        675                 680                 685             


Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro 
    690                 695                 700                 


Leu Ser Phe Gln Thr Leu Ile Pro Val Pro Arg Thr Asp Arg Leu Ser 
705                 710                 715                 720 


Met Cys Leu Phe Ser Tyr Arg His Leu Arg Asp Val Leu Leu Ile Ala 
                725                 730                 735     


Ala Arg Ile Leu Asn Leu Leu Gly Gln Arg Arg Trp Glu Thr Ile Lys 
            740                 745                 750         


Tyr Leu Gly Ser Ile Val Gln Tyr Trp Ser Ile Glu Leu Lys Lys Ser 
        755                 760                 765             


Ala Ile Asn Leu Leu Asp Ala Ile Ala Ile Val Val Ala Glu Gly Thr 
    770                 775                 780                 


Ala Arg Ile Leu Glu Ala Ile Gln Arg Ile Trp Arg Ala Ile Phe Asn 
785                 790                 795                 800 


Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Ala Ala Leu Gln 
                805                 810                 


<210> 251
<211> 884
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 251
Met Arg Val Thr Gly Thr Arg Lys Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Tyr Asn Val Lys Gly Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Asn Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Lys Pro Gln 
65                  70                  75                  80  


Glu Gln Trp Leu Lys Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asn Ala Thr Ser Ile Val Asn Met Thr Asp Val Ala Ser Asn 
    130                 135                 140                 


Arg Ser Arg Ser Asn Asp Thr Val Glu Asn Val Asn Gly Thr Ser Val 
145                 150                 155                 160 


Glu Asn Met Thr Ile Val Asn Ser Thr Asp Glu Ile Lys Asn Cys Ser 
                165                 170                 175     


Phe Asn Ile Thr Thr Gly Ile Gly Asp Lys Pro Lys Lys Glu Ser Ala 
            180                 185                 190         


Leu Phe Tyr Ser Leu Asp Ile Val Pro Leu Asn Lys Ser Ala Asn Asn 
        195                 200                 205             


Ser Glu Tyr Ile Leu Ile Thr Cys Lys Thr Ser Lys Ile Thr Gln Ala 
    210                 215                 220                 


Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro 
225                 230                 235                 240 


Ala Gly Tyr Ala Ile Leu Arg Cys Asp Asn Lys Thr Phe Asn Gly Thr 
                245                 250                 255     


Gly Pro Cys Asn Asn Val Ser Ser Val Gln Cys Thr His Gly Ile Arg 
            260                 265                 270         


Pro Val Val Thr Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu 
        275                 280                 285             


Asp Ile Ile Ile Arg Ser Val Asn Met Ser Asn Asn Ala Lys Thr Ile 
    290                 295                 300                 


Ile Val His Leu Asn Glu Ser Val Glu Ile Ile Cys Thr Arg Pro Asn 
305                 310                 315                 320 


Asn Asn Thr Arg Lys Ser Val Gly Met Gly Pro Gly Gln Ala Ile Tyr 
                325                 330                 335     


Thr Thr Gly Ala Ile Ile Gly Asn Ile Arg Gln Ala His Cys Asn Ile 
            340                 345                 350         


Ser Gly Arg Asn Arg Ser Arg Thr Leu Gln Arg Val Ser Glu Lys Leu 
        355                 360                 365             


Gln Lys Tyr Phe Tyr Asn Lys Thr Ile Lys Phe Gln Pro His Ser Gly 
    370                 375                 380                 


Gly Asp Pro Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe 
385                 390                 395                 400 


Phe Tyr Cys Asn Thr Ser Asp Leu Phe Asn Ser Thr Tyr Phe Asn Asn 
                405                 410                 415     


Thr Tyr Phe Asn Gly Val Tyr Asn Gly Thr Arg Asp Asn Gly Thr Ile 
            420                 425                 430         


Thr Leu Pro Cys Arg Ile Lys Gln Phe Ile Asn Met Trp Gln Arg Val 
        435                 440                 445             


Gly Arg Ala Met Tyr Ala Pro Pro Ile Gln Gly Leu Ile Thr Cys Arg 
    450                 455                 460                 


Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Thr Ile 
465                 470                 475                 480 


Asn Asn Thr Asn Asn Asn Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp 
                485                 490                 495     


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu 
            500                 505                 510         


Ile Arg Pro Leu Gly Val Ala Pro Thr Asp Ala Arg Arg Arg Val Val 
        515                 520                 525             


Gly Arg Glu Lys Arg Ala Val Met Gly Ala Leu Phe Leu Gly Phe Leu 
    530                 535                 540                 


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Ala Leu Thr Val 
545                 550                 555                 560 


Gln Thr Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
                565                 570                 575     


Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
            580                 585                 590         


Gly Ile Lys Gln Leu Gln Ala Gly Val Leu Ala Leu Glu Arg Tyr Leu 
        595                 600                 605             


Gln Asp Gln Gln Ile Leu Gly Ile Trp Gly Cys Ser Gly Lys Arg Ile 
    610                 615                 620                 


Cys Thr Thr Asp Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Thr Lys 
625                 630                 635                 640 


Glu Tyr Ile Trp Gly Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile 
                645                 650                 655     


Ser Asn Tyr Thr Gly Ile Ile Tyr Asp Leu Leu Glu Glu Ser Gln Asn 
            660                 665                 670         


Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Ala Leu Asp Ser Trp Lys 
        675                 680                 685             


Asn Leu Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys 
    690                 695                 700                 


Ile Phe Ile Met Ile Ile Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe 
705                 710                 715                 720 


Ala Val Leu Ser Ile Val His Arg Val Arg Gln Gly Tyr Ser Pro Leu 
                725                 730                 735     


Ser Phe Gln Thr Leu Ile Pro Asn Gln Arg Glu Pro Asp Arg Pro Gly 
            740                 745                 750         


Arg Ile Glu Glu Glu Gly Gly Gly Gln Asp Arg Asp Arg Ser Ile Arg 
        755                 760                 765             


Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Gly Asp Leu Arg Ser Leu 
    770                 775                 780                 


Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Cys Ile Ser Ile Ala Ala 
785                 790                 795                 800 


Arg Ala Gly Glu Leu Leu Gly Arg Ser Ser Leu Lys Gly Leu Gln Arg 
                805                 810                 815     


Gly Trp Glu Thr Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly 
            820                 825                 830         


Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile 
        835                 840                 845             


Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Phe Ile Gln Arg Ile 
    850                 855                 860                 


Cys Arg Ala Ile Cys Asn Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu 
865                 870                 875                 880 


Arg Ile Leu Leu 
                


<210> 252
<211> 875
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 252
Met Arg Val Thr Gly Ile Pro Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Ile Met Val Met Cys Asn Lys Thr Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Thr Asp Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Val Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Leu Glu Leu Lys Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Glu Val Thr Pro Asn Cys Thr Lys Val Asn Asn Ser Ser 
    130                 135                 140                 


Ser Asn Asn Thr Thr Val Ala Pro Thr Thr Ala Thr Cys Asn Asn His 
145                 150                 155                 160 


Thr Lys Asp Asn Ala Ser Ile Ile Gly Glu Arg Glu Met Arg Asn Cys 
                165                 170                 175     


Ser Phe Asn Ile Thr Thr Glu Ile Arg Asp Lys Lys Gln Lys Ala Tyr 
            180                 185                 190         


Ala Leu Phe Tyr Arg Pro Asp Ile Val Pro Leu Asn Gly Asn Pro Asn 
        195                 200                 205             


Thr Thr Glu Tyr Ile Leu Ile Asn Cys Asn Thr Ser Thr Ile Thr Gln 
    210                 215                 220                 


Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
225                 230                 235                 240 


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
                245                 250                 255     


Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
            260                 265                 270         


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
        275                 280                 285             


Glu Asp Ile Ile Ile Arg Ser Glu Asn Leu Thr Ser Asn Thr Lys Thr 
    290                 295                 300                 


Ile Ile Val His Leu Asn Glu Ser Val Lys Ile Glu Cys Leu Arg Pro 
305                 310                 315                 320 


Gly Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
                325                 330                 335     


Tyr Ala Thr Gly Ala Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn 
            340                 345                 350         


Ile Ser Thr Leu Ala Trp Asn Ala Thr Leu Glu Arg Val Arg Gly Lys 
        355                 360                 365             


Leu Lys Glu His Phe Pro Asn Lys Thr Ile Asn Phe Thr Ser Pro Ala 
    370                 375                 380                 


Gly Gly Asp Leu Glu Val Ile Thr His Ser Phe Asn Cys Gln Gly Glu 
385                 390                 395                 400 


Phe Phe Tyr Cys Asn Thr Thr Asn Leu Phe Asp Lys Phe Asn Ser Ser 
                405                 410                 415     


Gly Pro Asn Ile Thr Thr Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn 
            420                 425                 430         


Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly 
        435                 440                 445             


Asn Ile Thr Cys Asn Ser Asn Ile Thr Gly Leu Leu Leu Thr His Asp 
    450                 455                 460                 


Gly Ile Asn Ile Thr Tyr Asn Gly Thr Gly Asn Thr Thr Ile Ile Phe 
465                 470                 475                 480 


Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr 
                485                 490                 495     


Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Lys 
            500                 505                 510         


Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Leu Gly 
        515                 520                 525             


Ala Met Ile Leu Gly Phe Leu Gly Thr Ala Gly Ser Thr Met Gly Ala 
    530                 535                 540                 


Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
545                 550                 555                 560 


Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 
                565                 570                 575     


Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
            580                 585                 590         


Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp 
        595                 600                 605             


Gly Cys Pro Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ile 
    610                 615                 620                 


Ser Trp Ser Asn Lys Ser Tyr Asn Lys Ile Trp Asp Glu Met Thr Trp 
625                 630                 635                 640 


Met Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Asp Thr Ile Tyr Arg 
                645                 650                 655     


Leu Ile Glu Asp Ser Gln Ser Gln Gln Glu Lys Asn Glu Lys Asp Leu 
            660                 665                 670         


Leu Ala Leu Asp Ser Trp Asn Asn Leu Trp Asn Trp Phe Asn Ile Thr 
        675                 680                 685             


Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val Gly Gly Leu 
    690                 695                 700                 


Ile Gly Leu Arg Ile Ile Phe Cys Val Leu Ser Val Val Arg Arg Val 
705                 710                 715                 720 


Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Ile Pro Asn Pro 
                725                 730                 735     


Arg Gly Pro Asp Arg Pro Glu Arg Ile Glu Glu Gly Gly Gly Glu Gln 
            740                 745                 750         


Asp Arg Arg Lys Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala 
        755                 760                 765             


Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His His Leu Arg 
    770                 775                 780                 


Asp Phe Ile Leu Ile Val Leu Arg Ala Val Glu Leu Leu Gly Arg Ser 
785                 790                 795                 800 


Ser Leu Arg Gly Leu Gln Arg Val Trp Glu Ala Leu Lys Tyr Leu Gly 
                805                 810                 815     


Asn Leu Val Leu Tyr Trp Gly Gln Glu Leu Lys Lys Ser Ala Ile Ser 
            820                 825                 830         


Leu Leu Asp Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile 
        835                 840                 845             


Leu Glu Val Leu Gln Gly Ile Trp Arg Gly Ile Arg Asn Ile Pro Arg 
    850                 855                 860                 


Arg Ile Arg Gln Gly Phe Glu Ala Ser Leu Leu 
865                 870                 875 


<210> 253
<211> 859
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 253
Met Arg Val Met Gly Ile Leu Arg Ser Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Val Met Thr Cys Asn Val Gly Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asp Pro 
65                  70                  75                  80  


Gln Glu Leu Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Lys Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Val Lys Gly Asn Val Thr Tyr Ser Asp Lys Gly Asn 
    130                 135                 140                 


Leu Ala His Ser Asn Ser Thr Asp Glu Met Lys Asn Cys Thr Phe Asn 
145                 150                 155                 160 


Val Thr Thr Glu Leu Arg Asp Lys Ser Lys Lys Glu Ser Ala Leu Phe 
                165                 170                 175     


Tyr Arg Leu Asp Ile Glu Thr Leu Asp Pro Lys Gly Asn Ser Ser Asn 
            180                 185                 190         


Asn Asn Ser Ser Tyr Lys Glu Tyr Ile Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Thr Ile Ala Gln Ser Cys Pro Lys Ile Thr Phe Asp Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys 
225                 230                 235                 240 


Ala Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Gly Gly Ile Ile Ile Arg Ser Ala Asn Leu Thr Asp 
        275                 280                 285             


Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Gly Ile Thr 
    290                 295                 300                 


Cys Val Arg Pro Gly Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Thr Phe Tyr Ala Thr Gly Gln Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Ile Thr Gly Ser Glu Trp Asn Arg Thr Ile Asp Arg 
            340                 345                 350         


Val Gly Lys Lys Leu Gln Glu His Phe Pro Asn Lys Thr Ile Asn Phe 
        355                 360                 365             


Thr Gln Pro Ser Gly Gly Asp Leu Glu Ile Thr Met His Ser Phe Asn 
    370                 375                 380                 


Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Thr 
385                 390                 395                 400 


Ser Gly Leu Phe Asn Asp Thr Glu Gly Trp Ile Asn Pro Ile Asn Lys 
                405                 410                 415     


Thr Ser Asn Ile Thr Ile Gln Cys Arg Ile Lys Gln Phe Ile Asn Met 
            420                 425                 430         


Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn 
        435                 440                 445             


Ile Thr Cys Thr Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
    450                 455                 460                 


Gly Asn Ser Ser Ser Asn Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp 
465                 470                 475                 480 


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu 
                485                 490                 495     


Ile Lys Pro Leu Gly Ile Ala Pro Thr Thr Ala Lys Arg Arg Val Val 
            500                 505                 510         


Glu Arg Glu Lys Arg Ala Ala Leu Gly Ala Met Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Val Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Thr Gln 
    610                 615                 620                 


Asn Glu Ile Trp Asn Asn Met Thr Trp Met Gln Trp Asp Lys Glu Val 
625                 630                 635                 640 


Ser Asn Tyr Thr Asp Gln Ile Tyr Arg Leu Leu Glu Lys Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Arg Asp Leu Leu Ser Leu Asp Ser Trp Asn 
            660                 665                 670         


Ser Leu Trp Ser Trp Phe Ser Ile Thr Lys Trp Leu Trp Tyr Ile Lys 
        675                 680                 685             


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe 
    690                 695                 700                 


Ala Val Leu Ser Val Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
705                 710                 715                 720 


Ser Phe Gln Thr Leu Ile Pro Ser Pro Arg Gly Pro Asp Arg Pro Gly 
                725                 730                 735     


Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asn Arg Ser Thr Arg 
            740                 745                 750         


Leu Val Ser Gly Phe Leu Ala Leu Val Trp Asp Asp Leu Arg Ser Leu 
        755                 760                 765             


Ser Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Thr 
    770                 775                 780                 


Arg Ala Ala Glu Leu Leu Gly Arg Ser Ser Leu Arg Gly Leu Gln Arg 
785                 790                 795                 800 


Gly Trp Glu Ala Leu Lys Tyr Leu Gly Asn Leu Val Gln Tyr Trp Gly 
                805                 810                 815     


Gln Glu Leu Lys Arg Ser Ala Ile Ser Leu Phe Asp Thr Ile Ala Ile 
            820                 825                 830         


Ile Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Ala Gln Arg Ile 
        835                 840                 845             


Cys Arg Ala Arg Gln Gly Glu Thr Ala Leu Leu 
    850                 855                 


<210> 254
<211> 858
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 254
Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Leu Ile Cys Asn Gly Met Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Ser 
        35                  40                  45              


Pro Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Ser Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Leu Val Leu Lys Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Glu Gln Met His Gln Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asp Asn Ser Thr Thr Ile Asn Gly Thr Ile His 
    130                 135                 140                 


Pro Asn Glu Glu Gly Lys Asn Cys Ser Phe Tyr Ile Thr Thr Lys Leu 
145                 150                 155                 160 


Lys Leu Lys Ile Arg Gln Lys Phe Ala Leu Phe Tyr Asp Pro Asp Asn 
                165                 170                 175     


Leu Ile Leu Ile Asp Asn Asp Asn Ser Met Tyr Leu Leu Asn Cys Asn 
            180                 185                 190         


Thr Ser Thr Ile Thr Gln Thr Cys Pro Trp Val Ser Phe Asp Phe Asp 
        195                 200                 205             


Pro Ile Pro Tyr Cys Asp Arg Ala Ala Tyr Gly Ile Leu Ile Arg Asn 
    210                 215                 220                 


Asn Asn Lys Phe Asn Val Thr Gly Pro Cys Pro Ser Val Asn Ala Gly 
225                 230                 235                 240 


Gln Cys Thr Arg Gly Ile Gly Thr Met Pro Ser Thr Pro Leu Leu Leu 
                245                 250                 255     


Asn Gly Asn Ile Thr Lys Glu Asp Ile Val Ile Ile Ser Glu Tyr Leu 
            260                 265                 270         


Asp Asn Asn Ala Asn Val Ile Ile Ile Gln Leu Asn Lys Thr Val Pro 
        275                 280                 285             


Val Asn Cys Thr Arg Pro Arg His Asn Thr Arg Thr Arg Val Arg Met 
    290                 295                 300                 


Arg Pro Gly Gln Arg Leu Tyr Val Ser Ala Asp Ile Ile Gly Asn Ile 
305                 310                 315                 320 


Arg Leu Ala His Cys His Cys Ile Gly Ser Gly Arg Tyr Asp Thr Leu 
                325                 330                 335     


Glu Leu Val Lys Leu Asn Thr Leu Glu His Cys Leu Tyr His Lys Thr 
            340                 345                 350         


Ile Met Phe Thr His Pro Ser Gly Gly Ala Leu Pro Thr Thr Thr His 
        355                 360                 365             


Thr Leu Asn Cys Gly Gly Glu Leu Phe Tyr Cys Ser Thr Ser Ser Leu 
    370                 375                 380                 


Leu Asn Phe Thr Trp Arg Ser Leu Phe Cys His Ala Gln Ala Pro Phe 
385                 390                 395                 400 


Gln Glu Thr His Asn Asn Ser Thr Asn Asn Ile Pro Phe Pro Cys Arg 
                405                 410                 415     


Ile Lys Gln Phe Ile Asn Met Trp Gln Thr Val Gly Arg Ala Met Tyr 
            420                 425                 430         


Ala Pro Pro Ile Ala Gly Val Ile Thr Cys Asn Ser Asn Ile Thr Gly 
        435                 440                 445             


Leu Leu Leu Thr Arg Asp Gly Gly Asn Pro Thr Asn Ser Thr Glu Gly 
    450                 455                 460                 


Asn Asn Glu Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
465                 470                 475                 480 


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro 
                485                 490                 495     


Leu Gly Val Val Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu 
            500                 505                 510         


Lys Arg Ala Ala Leu Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala 
        515                 520                 525             


Gly Ser Thr Met Gly Ala Ala Ser Ile Ala Leu Thr Val Gln Ala Arg 
    530                 535                 540                 


Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala 
545                 550                 555                 560 


Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys 
                565                 570                 575     


Gln Leu Gln Thr Arg Val Leu Ala Leu Glu Arg Tyr Leu Arg Asp Gln 
            580                 585                 590         


Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr 
        595                 600                 605             


Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Glu Glu Ile 
    610                 615                 620                 


Trp Asp Asn Met Thr Trp Met Gln Trp Glu Arg Glu Ile Asp Asn Tyr 
625                 630                 635                 640 


Thr Asp Ile Ile Tyr Asn Leu Leu Glu Val Ser Gln Ile Gln Gln Glu 
                645                 650                 655     


Thr Asn Glu Lys Asp Leu Leu Ala Leu Asp Lys Trp His Asn Leu Trp 
            660                 665                 670         


Ser Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile 
        675                 680                 685             


Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu 
    690                 695                 700                 


Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln 
705                 710                 715                 720 


Thr Leu Ile Pro Ser Pro Arg Gly Pro Asp Arg Pro Gly Gly Ile Glu 
                725                 730                 735     


Glu Glu Gly Gly Glu Asn Asp Arg Gly Arg Ser Ile Arg Leu Val Ser 
            740                 745                 750         


Gly Phe Leu Gly Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe 
        755                 760                 765             


Cys Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Ala Ala Arg Val Val 
    770                 775                 780                 


Glu Leu Leu Gly Gln Arg Gly Trp Glu Ile Leu Lys Tyr Leu Gly Ser 
785                 790                 795                 800 


Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu 
                805                 810                 815     


Leu Asp Thr Val Ala Ile Val Val Ala Glu Gly Thr Asp Arg Ile Ile 
            820                 825                 830         


Glu Leu Ile Gln Arg Ala Trp Arg Thr Ile Cys Asn Ile Pro Val Arg 
        835                 840                 845             


Ile Arg Gln Gly Phe Glu Ala Ala Leu Leu 
    850                 855             


<210> 255
<211> 866
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 255
Met Thr Val Met Gly Ile Gln Met Asn Cys Pro Gln Trp Trp Arg Trp 
1               5                   10                  15      


Gly Ile Leu Ser Leu Trp Met Phe Met Ile Trp Asn Val Trp Gly Lys 
            20                  25                  30          


Gly Asn Leu Arg Val Thr Val Tyr Tyr Gly Val Pro Val Trp Val Glu 
        35                  40                  45              


Ala Lys Thr Thr Leu Phe Ala Ser Asp Ala Asn Ala His Ser Glu Glu 
    50                  55                  60                  


Val His Asn Val Arg Ala Thr His Ala Cys Val Cys Ala His Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Ile Asn Val Thr Glu Asn Phe Asn Met Cys Lys Asn Asp 
                85                  90                  95      


Met Glu Lys Gln Met His Glu Asp Ile Val Ser Leu Cys His Gln Ser 
            100                 105                 110         


Leu Lys Pro Cys Val Arg Val Thr Pro Leu Cys Val Thr Cys His Leu 
        115                 120                 125             


Thr Ser Ser Val Ile Thr Asp Thr Asp Thr Ile Ser Ser Ser Leu Ile 
    130                 135                 140                 


Ile Asn Asp Asp Asp Ser Asn Met Asn Cys Cys Ser Phe Ile Thr Thr 
145                 150                 155                 160 


Ala Val Asn Arg Asp Lys Lys Lys Asp Asp Ala Ala Leu Tyr Tyr Arg 
                165                 170                 175     


Leu Val Val Val Pro Asp Asp Glu Glu Lys Lys Asn Asn Cys Ser Glu 
            180                 185                 190         


Cys Arg Leu Ile Asn Cys Asn Ser Ser Ala Val Pro Gln Ala Cys Thr 
        195                 200                 205             


Lys Val Ser Asp Glu Pro Ile Leu Ile His Tyr Cys Ala Pro Ala Gly 
    210                 215                 220                 


Tyr Ala Ile Ile Lys Cys Asn Asp Thr Thr Phe Asn Ala Thr Ala Pro 
225                 230                 235                 240 


Cys Asn Asn Val Thr Ala Leu Gln Cys Pro Arg Gly Ile Thr Pro Val 
                245                 250                 255     


Val Ser His Gln Leu Leu Leu Asn Gly Ser Ala Ala Glu Arg Gly Asp 
            260                 265                 270         


Ser Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Thr Thr Ile Ile Val 
        275                 280                 285             


His Leu Lys Asn Pro Val Glu Ile Ser Arg Asn Tyr Cys Thr Arg Pro 
    290                 295                 300                 


His Ile Asn Thr Arg Lys Ser Met Arg Ile Gly Pro Gly Gln Ile Phe 
305                 310                 315                 320 


Tyr Ala Thr Gly Asp Ile Ile Gly Asn Ile Arg Gln Ala His Cys Asn 
                325                 330                 335     


Ile Ser Ala Lys Glu Trp Asn Glu Thr Leu Leu Met Val Ser Glu Lys 
            340                 345                 350         


Leu Leu Lys His Phe Pro Asn Lys Thr Thr Ile Asn Phe Pro Ser Ser 
        355                 360                 365             


Ser Gly Glu Asp Gln Thr Ile Thr Lys Arg Ser Phe Cys Arg Gly Glu 
    370                 375                 380                 


Gln Phe Phe Tyr Cys Asn Thr Ser Ile Leu Ser Asn Thr Thr Tyr Ser 
385                 390                 395                 400 


Tyr Asn Ser Thr Ser Asn Thr Thr Cys Ser Thr Asn Asn Thr Thr Thr 
                405                 410                 415     


Ser Thr Phe Thr Leu Gln Cys Arg Arg Ile His Ile Ile Ile Met Cys 
            420                 425                 430         


Leu Glu Pro Gly Leu Ala Ile Asp Ala Ser Pro Thr Ala Gly Glu Ile 
        435                 440                 445             


Ile Ser Lys Ser Asn Thr Thr Asp Leu Leu Leu Thr Arg Ala Gly Gly 
    450                 455                 460                 


Ser Asn Arg Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
465                 470                 475                 480 


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro 
                485                 490                 495     


Leu Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu 
            500                 505                 510         


Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Val 
        515                 520                 525             


Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala 
    530                 535                 540                 


Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg 
545                 550                 555                 560 


Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile 
                565                 570                 575     


Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp 
            580                 585                 590         


Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr 
        595                 600                 605             


Thr Asn Val Pro Trp Asn Lys Ser Trp Ser Asn Lys Thr Gln Lys Asp 
    610                 615                 620                 


Ile Trp Asp Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Ser Asn 
625                 630                 635                 640 


Tyr Thr Asp Ile Ile Tyr Ser Leu Leu Val Asp Ser Gln Thr Gln Gln 
                645                 650                 655     


Glu Lys Asn Glu Lys Glu Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu 
            660                 665                 670         


Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe 
        675                 680                 685             


Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val 
    690                 695                 700                 


Leu Pro Ile Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe 
705                 710                 715                 720 


Gln Thr Ile Ile Pro Asn Pro Arg Gly Pro Asp Arg Leu Gly Arg Ile 
                725                 730                 735     


Glu Glu Glu Gly Gly Glu Gln Asp Arg Asn Arg Ser Ile Arg Leu Val 
            740                 745                 750         


Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu 
        755                 760                 765             


Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Val Val Arg Ala 
    770                 775                 780                 


Val Glu Leu Leu Gly His Ser Ser Leu Arg Gly Ile Gln Arg Gly Trp 
785                 790                 795                 800 


Glu Ala Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu 
                805                 810                 815     


Ile Lys Lys Ser Ala Ile Ser Leu Phe Asp Thr Leu Ala Ile Val Val 
            820                 825                 830         


Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Val Gln Arg Ile Phe Arg 
        835                 840                 845             


Ala Ile Cys Asn Ile Pro Arg Arg Ile Arg Gln Gly Ser Glu Ala Ser 
    850                 855                 860                 


Leu Leu 
865     


<210> 256
<211> 887
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 256
Met Arg Val Arg Gly Ile Leu Arg Asn Trp Gln Gln Trp Gly Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Lys Asp Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
        35                  40                  45              


Ala Lys Thr Thr Leu Phe Cys Ala Ser Asn Ala Lys Ala Tyr Glu Arg 
    50                  55                  60                  


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
65                  70                  75                  80  


Asn Pro Gln Lys Ile Asp Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
                85                  90                  95      


Trp Lys Asn Asp Met Val Asp Gln Met His Ala Asp Val Ile Ser Leu 
            100                 105                 110         


Trp Lys Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
        115                 120                 125             


Thr Leu Asn Cys Thr Glu Val Thr Val Ile Lys Asn Thr Gly Val Asn 
    130                 135                 140                 


Met Thr Asn Asn Ser Thr Ser Thr Ser Ile Asp Thr Ser Ile Leu Asn 
145                 150                 155                 160 


Asp Thr Ser Asn Ala Asp Leu Lys Asn Cys Ser Phe Asn Thr Thr Thr 
                165                 170                 175     


Lys Ile Ser Asp Asn Glu Ile Phe Glu Phe Ala Val Asn Asn Thr Leu 
            180                 185                 190         


Asp Val Glu Pro Ile Asp Gly Thr Tyr Thr Ser Ile Thr Phe Arg Leu 
        195                 200                 205             


Thr Asn Ser Asn Ser Ser Ser Ile Pro Gln Ala Cys Pro Lys Val Ser 
    210                 215                 220                 


Phe Asp Pro Leu Pro Ile Pro Tyr Cys Ala Pro Ala Gly Tyr Thr Gly 
225                 230                 235                 240 


Leu Arg Cys Ser Asn Asn Thr Phe Thr Gly Thr Gly Pro Cys Arg Asn 
                245                 250                 255     


Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr 
            260                 265                 270         


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile Met Ile Arg 
        275                 280                 285             


Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile Ile Val His Leu Asn 
    290                 295                 300                 


Glu Ser Val Asn Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys 
305                 310                 315                 320 


Gly Val Gly Ile Gly Pro Gly Gln Ala Ile Tyr Ala Thr Gly Ala Ile 
                325                 330                 335     


Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Thr Lys Arg Gly Trp 
            340                 345                 350         


Asn Gly Leu Pro Gln Lys Val Lys Gly Lys Leu Arg Glu His Leu Pro 
        355                 360                 365             


Gly Lys Leu Ile Ile Phe Gln Pro His Ser Gly Gly Asp Leu Gln Ile 
    370                 375                 380                 


Thr Met His Thr Phe Asn Trp Gly Gly Glu Phe Phe Tyr Cys Asn Thr 
385                 390                 395                 400 


Ser Val Leu Ser Asn Ser Thr His Asn Ser Gly Thr Gly Trp His Leu 
                405                 410                 415     


Gln Ser Ser Asp Ile Asn Ser Tyr Ala Thr Ile Ala Val Ser Tyr Arg 
            420                 425                 430         


Ile Gly Gln Ile Ile Asn Met Trp Arg Gln Val Gly Arg Ala Ile Tyr 
        435                 440                 445             


Gly Pro Pro Val Ala Arg Lys Met Ser Ala His Pro Ser Thr Thr Gly 
    450                 455                 460                 


Leu Leu Leu Val Cys Asp Gly Gly Glu Lys Ser Leu Asn Ser Thr Asn 
465                 470                 475                 480 


Gly Thr Gly Ile Thr Asn Ala Thr Glu Ile Phe Arg Pro Gln Gly Gly 
                485                 490                 495     


Asp Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
            500                 505                 510         


Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Glu Ala Arg Arg Arg Val 
        515                 520                 525             


Val Glu Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Ile Leu Gly 
    530                 535                 540                 


Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Ala Leu 
545                 550                 555                 560 


Thr Ala Gln Ala Arg Thr Val Met Ala Gly Ile Val Gln Gln Gln Ser 
                565                 570                 575     


Asn Leu Leu Arg Ala Ile Asp Ala Gln Gln His Met Leu Gln Leu Thr 
            580                 585                 590         


Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Leu Glu Arg 
        595                 600                 605             


Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys 
    610                 615                 620                 


Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Thr Ser Trp Ser Asn Arg 
625                 630                 635                 640 


Ser Lys Glu Glu Ile Trp Asn Asn Met Thr Trp Met Gln Trp Glu Arg 
                645                 650                 655     


Glu Ile Asp Asn Tyr Thr Glu Ile Ile Tyr Gln Leu Leu Gly Glu Ser 
            660                 665                 670         


Gln Ile Gln Gln Glu Gln Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser 
        675                 680                 685             


Trp Lys Asn Leu Trp Ser Trp Phe Ser Ile Ser Asn Trp Leu Trp Tyr 
    690                 695                 700                 


Ile Arg Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile 
705                 710                 715                 720 


Ile Phe Ala Val Leu Ser Ile Ile His Arg Val Arg Gln Gly Tyr Ser 
                725                 730                 735     


Pro Leu Ser Leu Gln Thr Leu Ile Pro Asn Ser Arg Glu Pro Leu Asp 
            740                 745                 750         


Arg Leu Gly Arg Ile Glu Glu Gly Gly Gly Glu Gln Asp Arg Ser Arg 
        755                 760                 765             


Ser Ile Arg Leu Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu 
    770                 775                 780                 


Arg Ser Leu Cys Leu Phe Cys Tyr His Leu Leu Arg Asp Phe Ile Leu 
785                 790                 795                 800 


Ile Val Ala Arg Val Gly Glu Leu Leu Gly His Ser Ser Leu Arg Gly 
                805                 810                 815     


Leu Gln Lys Gly Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu Val Gln 
            820                 825                 830         


Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu Leu Asp Thr 
        835                 840                 845             


Val Ala Ile Ala Val Ala Gly Arg Thr Asp Arg Ile Ile Glu Val Ile 
    850                 855                 860                 


Gln Glu Ile Cys Arg Ala Ile Tyr His Ile Pro Arg Arg Ile Arg Gln 
865                 870                 875                 880 


Gly Phe Glu Ala Ala Leu Leu 
                885         


<210> 257
<211> 863
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 257
Met Lys Gly Arg Arg Asn Thr Glu Asn Leu Ser Pro Gly Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Met His Lys Gly Glu Gly Asn 
            20                  25                  30          


Leu Trp Phe Thr Val Tyr Tyr Gly Leu Pro Val Trp Thr Glu Pro Lys 
        35                  40                  45              


Pro Thr Leu Phe Gly Ala Ser Asn Ala Lys Gly Tyr Lys Thr Glu Val 
    50                  55                  60                  


His Met Val Trp Ala Thr His Ala Cys Val Pro Thr Asn Pro Asn Gln 
65                  70                  75                  80  


Gln Asp Leu Val Leu Glu Asn Val Thr Glu Asn Phe Ser Met Trp Lys 
                85                  90                  95      


Asn Asp Met Leu Asp Gln Met His Glu His Val Val Ile Phe Ser Asp 
            100                 105                 110         


Gln Gly Leu Lys Pro Tyr Ala Lys Val Thr Ser Leu Thr Val Thr Val 
        115                 120                 125             


Thr Cys Thr Asp Leu Lys Asn Ser Thr Phe Thr Ser Thr Ser Ser Asn 
    130                 135                 140                 


Asp Thr Ser Met Val Thr Glu Ser Glu Glu Met Lys Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Ile Thr Thr Glu Ile Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu 
                165                 170                 175     


Phe Tyr Arg Leu Asp Ile Val Pro Leu Lys Glu Lys Glu Asp Asn Asn 
            180                 185                 190         


Ser Asp Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Val Thr Gln Ala 
        195                 200                 205             


Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro 
    210                 215                 220                 


Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr 
225                 230                 235                 240 


Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys 
                245                 250                 255     


Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys 
            260                 265                 270         


Glu Ile Val Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Ile Ile 
        275                 280                 285             


Ile Val His Leu Asn Glu Ser Val Glu Ile Val Cys Thr Arg Pro Asn 
    290                 295                 300                 


Asn Asn Thr Arg Lys Ser Met Arg Ile Gly Pro Gly Gln Thr Phe Tyr 
305                 310                 315                 320 


Ala Thr Gly Asp Ile Ile Gly Asn Ile Arg Gln Ala Tyr Cys Asn Ile 
                325                 330                 335     


Ser Glu Lys Arg Trp Asn Glu Thr Leu Gln Lys Val Ser Lys Lys Leu 
            340                 345                 350         


Arg Glu His Phe Pro Asn Lys Thr Ile Lys Phe Lys Pro Ser Ser Gly 
        355                 360                 365             


Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe 
    370                 375                 380                 


Phe Tyr Cys Asn Thr Ser Lys Leu Phe Asn Ser Thr Tyr Pro Pro Asn 
385                 390                 395                 400 


Ser Thr Asp Thr Tyr Met Asn Ser Ala Asn Thr Ser Asn Ile Ile Leu 
                405                 410                 415     


Gln Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Gly Val Gly Gln 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Glu Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Gln Thr Glu 
    450                 455                 460                 


Glu Glu Thr Phe Thr Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Val Phe Leu Gly Val Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Thr Arg Val Leu Ala Val Glu Gly Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         


Leu Arg Ile Trp Ala Ala Ser Gly Lys Leu Ile Cys Thr Thr Asn Val 
        595                 600                 605             


Pro Trp Thr Pro Ser Trp Ser Ile Lys Ser Gln Glu Glu Ile Trp Asn 
    610                 615                 620                 


Asn Met Thr Trp Met Gln Cys Asp Arg Glu Ile Thr Tyr Thr Glu Asn 
625                 630                 635                 640 


Leu Ile Gln Cys Leu Ala Pro Gln Pro Arg Lys Trp Lys Asp Thr Thr 
                645                 650                 655     


Cys Asn Gly Asp Leu Asp Leu Asp Lys Trp Gln Asn Leu Trp Lys Trp 
            660                 665                 670         


Phe Asn Ile Pro Lys Trp Leu Trp Tyr Ile Glu Leu Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu 
705                 710                 715                 720 


Leu Pro Ser Pro Arg Gly Pro Asp Arg Leu Gly Gly Thr Glu Glu Glu 
                725                 730                 735     


Ser Gly Glu Gln Asp Arg Asp Arg Ser Val Arg Leu Val Asn Gly Phe 
            740                 745                 750         


Leu Pro Leu Val Trp Asn Asp Leu Arg Ser Leu Cys Leu Phe Cys Tyr 
        755                 760                 765             


His Gln Leu Arg Thr Phe Ile Leu Val Thr Ala Arg Ala Val Glu Leu 
    770                 775                 780                 


Leu Gly Arg Ser Ile Leu Arg Gly Leu Gln Thr Gly Trp Glu Ala Leu 
785                 790                 795                 800 


Lys Tyr Leu Gly Gly Ile Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys 
                805                 810                 815     


Ser Ala Ile Ser Leu Phe Asp Thr Leu Ala Ile Val Val Ala Glu Gly 
            820                 825                 830         


Thr Asp Arg Ile Ile Glu Val Val Arg Gly Phe Phe Arg Ala Ile Tyr 
        835                 840                 845             


Asn Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Ala Ala Leu Gln 
    850                 855                 860             


<210> 258
<211> 835
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 258
Met Arg Val Met Gly Ile His Glu Glu Leu Ser Thr Met Gly Trp Ile 
1               5                   10                  15      


Trp Gly Ile Leu Gly Phe Trp Met Leu Leu Ile Cys Asn Val Met Gly 
            20                  25                  30          


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Thr Glu Ala 
        35                  40                  45              


Asn Pro Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Glu Pro Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Leu Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Gly Met Val Glu Gln Met His Gln Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Trp Val Thr 
        115                 120                 125             


Leu Asn Cys Ser Asp Val Asn Val Thr Ala Ile Ile Asp Ala Asp Ile 
    130                 135                 140                 


Leu Thr Met Tyr Glu Pro Val Ile Asn Arg Ser Phe Ser Thr Thr Pro 
145                 150                 155                 160 


Lys Leu Lys Lys Lys Thr Glu Thr Asp Leu Phe His Tyr Val Glu Val 
                165                 170                 175     


Glu Ala Leu Asp Met Thr Ala Thr Asp Asp Gly Tyr Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Thr Leu Thr Ile Thr Cys Pro Cys Val Ser Phe Ala Pro Val 
        195                 200                 205             


Pro Ile Pro Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Pro Ile Arg Asn 
    210                 215                 220                 


Gly Asn Asn Phe Thr Gly Pro Gly Pro Cys Pro Ser Val Asn Ala Phe 
225                 230                 235                 240 


Gln Gly Thr Arg Gly Leu Glu Pro Val Ala Ser Thr Pro Leu Leu Leu 
                245                 250                 255     


Ile Gly Asn Val Ala Lys Asn Glu Ile Val Ile Ile Ser Glu Thr Leu 
            260                 265                 270         


Thr His Asn Val Lys Met Val Met Val Gln Leu Asn Glu Thr Val Thr 
        275                 280                 285             


Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile 
    290                 295                 300                 


Gly Pro Gly Gln Ala Phe Pro Ala Thr Ala Thr Ile Glu Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala His Cys Asn Ile Asn Lys Thr Glu Trp Asn Asn Thr Leu 
                325                 330                 335     


Gln Lys Val Arg Glu Lys Leu Arg Lys His Phe Asn Lys Thr Ile Lys 
            340                 345                 350         


Phe Asp Ser Ser Ser Gly Gly Asp Pro Glu Ile Thr Thr His Ser Phe 
        355                 360                 365             


Asn Cys Arg Gly Glu Phe Phe Tyr Trp Asp Thr Thr Lys Leu Phe Asn 
    370                 375                 380                 


Glu Thr Tyr Asn Asn Thr Asp Ala Asn Gly Thr Ile Ile Met Pro Cys 
385                 390                 395                 400 


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Arg Ala Met 
                405                 410                 415     


Tyr Ala Pro Pro Ile Glu Gly Pro Ile Thr Cys Ile Ser Asn Ile Thr 
            420                 425                 430         


Gly Leu Leu Leu Thr His Asp Gly Glu Glu Asn Asp Thr Glu Thr Phe 
        435                 440                 445             


Arg Pro Trp Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
    450                 455                 460                 


Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro Thr Lys 
465                 470                 475                 480 


Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Ala Leu Gly Ala 
                485                 490                 495     


Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
            500                 505                 510         


Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
        515                 520                 525             


Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 
    530                 535                 540                 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu 
545                 550                 555                 560 


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly 
                565                 570                 575     


Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser 
            580                 585                 590         


Trp Ser Asn Lys Ser Gln Glu Glu Ile Trp Asp Asn Met Thr Trp Met 
        595                 600                 605             


Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr Gly Ile Ile Tyr Asn Leu 
    610                 615                 620                 


Leu Glu Val Ser Gln Asn Gln Gln Glu Lys Asn Glu Glu Asp Leu Leu 
625                 630                 635                 640 


Ala Leu Asp Lys Trp Gln Asn Leu Trp Asn Trp Phe Asp Ile Thr Gln 
                645                 650                 655     


Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile Val Gly Gly Leu Ile 
            660                 665                 670         


Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg 
        675                 680                 685             


Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Ile Pro Asn Pro Arg 
    690                 695                 700                 


Gly Pro Asp Arg Pro Gly Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp 
705                 710                 715                 720 


Arg Asp Arg Ser Ile Arg Phe Val Asn Gly Phe Leu Ala Leu Ala Trp 
                725                 730                 735     


Asp Asp Leu Arg Ser Leu Cys Leu Phe Ile Tyr Arg Gln Leu Arg Asp 
            740                 745                 750         


Leu Ile Leu Ile Ala Ala Arg Ala Val Glu Ile Leu Gly Gln Arg Gly 
        755                 760                 765             


Trp Glu Thr Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly Leu 
    770                 775                 780                 


Glu Leu Lys Lys Arg Ala Ile Ser Met Leu Asp Thr Thr Ala Ile Val 
785                 790                 795                 800 


Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Val Val Gln Arg Thr Trp 
                805                 810                 815     


Arg Ile Ile Cys Asn Ile Leu Thr Arg Ile Arg Gln Gly Phe Glu Ala 
            820                 825                 830         


Ala Leu Leu 
        835 


<210> 259
<211> 841
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 259
Met Arg Val Met Gly Ile Gln Arg Asn Tyr Gln Arg Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Phe Met Ile Cys Asn Val Arg Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asp 
        35                  40                  45              


Pro Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Leu Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Gly Met Val Asp Gln Met His Gln Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Ser Cys Asn Asn Thr Ile Val Val Asn Ala Thr Ile Arg Met Ile Gln 
    130                 135                 140                 


Lys Asp Cys Ser Phe Asn Thr Thr Thr Glu Leu Arg Asp Lys Arg Gln 
145                 150                 155                 160 


Thr Ala Tyr Ala Leu Phe Tyr Lys Leu Asp Ile Val Ala Leu Ser Glu 
                165                 170                 175     


Lys Ser Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
            180                 185                 190         


Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys 
        195                 200                 205             


Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Arg Asp Ala Asn Phe Asn 
    210                 215                 220                 


Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly 
225                 230                 235                 240 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
                245                 250                 255     


Glu Asn Glu Thr Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys 
            260                 265                 270         


Ile Ile Ile Val Gln Leu Lys Thr Pro Val Glu Ile Asn Cys Thr Arg 
        275                 280                 285             


Pro Ala Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr 
    290                 295                 300                 


Phe Tyr Ala Thr Glu Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
305                 310                 315                 320 


Asn Ile Ser Gly Lys Thr Trp Asn Ala Thr Leu Lys Asp Val Gly Asp 
                325                 330                 335     


Lys Leu Lys Arg His Phe Pro Asn Gly Thr Ile Lys Phe Leu Pro Ser 
            340                 345                 350         


Ser Gly Gly Asp Ile Gln Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
        355                 360                 365             


Glu Phe Phe Tyr Cys Cys Thr Ser Tyr Leu Leu Asn Asn Thr Leu Asp 
    370                 375                 380                 


Asn Asn Thr Ile Asn Asp Thr Thr Asn Asn Gly Gly Thr Asn Asp Ser 
385                 390                 395                 400 


Ile Ile Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn Val Gly Gln Glu 
                405                 410                 415     


Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys 
            420                 425                 430         


Arg Ser Asn Ile Thr Gly Ile Leu Leu Ala Glu Asp Gly Gly Pro Ile 
        435                 440                 445             


Asn Glu Thr Glu Thr Phe Arg Arg Gly Gly Gly Asp Met Arg Asp Asn 
    450                 455                 460                 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu 
465                 470                 475                 480 


Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gly Arg Glu Lys 
                485                 490                 495     


Arg Ala Ala Leu Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly 
            500                 505                 510         


Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln 
        515                 520                 525             


Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile 
    530                 535                 540                 


Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
545                 550                 555                 560 


Leu Gln Thr Arg Val Leu Ala Leu Glu Arg Tyr Leu Arg Asp Gln Gln 
                565                 570                 575     


Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala 
            580                 585                 590         


Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Ser Gln Glu Glu Ile Trp 
        595                 600                 605             


Glu Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr 
    610                 615                 620                 


Asn Ile Ile Tyr Glu Leu Leu Glu Val Ser Gln Asn Gln Gln Glu Lys 
625                 630                 635                 640 


Asn Glu Lys Asp Leu Leu Glu Leu Asp Lys Trp Gln Asn Leu Trp Asn 
                645                 650                 655     


Trp Phe Asp Ile Thr His Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met 
            660                 665                 670         


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser 
        675                 680                 685             


Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
    690                 695                 700                 


Leu Ile Pro Asn Arg Arg Gly Pro Thr Ser Pro Gly Gly Leu Glu Glu 
705                 710                 715                 720 


Glu Gly Glu Asp Gln Asp Arg Gly Arg Ser Phe Arg Leu Val Arg Gly 
                725                 730                 735     


Phe Leu Ala Leu Pro Trp Asp Val Leu Arg Thr Leu Cys Leu Phe Ser 
            740                 745                 750         


Ser His Arg Trp Arg Asp Leu Phe Trp Ile Ala Ala Arg Ala Val Glu 
        755                 760                 765             


Leu Leu Asp Gln Arg Gly Trp Lys Thr Phe Asn Phe Leu Gly Thr Leu 
    770                 775                 780                 


Val Gln Tyr Gly Gly Arg Lys Leu Lys Lys Ser Val Ile Ser Leu Phe 
785                 790                 795                 800 


Asn Thr Pro Pro Ile Leu Val Ala Glu Glu Thr Asp Arg Phe Met Lys 
                805                 810                 815     


Leu Phe Gln Arg Phe Gly Arg Ala Phe Ser Asn Ile Pro Gly Arg Leu 
            820                 825                 830         


Ser Gln Gly Leu Glu Ala Ala Phe Gln 
        835                 840     


<210> 260
<211> 875
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 260
Met Arg Val Arg Gly Ile Leu Arg Asn Tyr Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Ile Tyr Asn Val Met Gly Asn Leu Trp 
            20                  25                  30          


Val Thr Val Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu 
        35                  40                  45              


Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Arg Glu Val His Asn Ile 
    50                  55                  60                  


Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Leu 
65                  70                  75                  80  


Val Leu Lys Asn Val Ile Glu Asn Phe Asn Met Trp Lys Asn Asp Met 
                85                  90                  95      


Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Glu Ser Leu 
            100                 105                 110         


Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr 
        115                 120                 125             


Lys Val Thr Val Asn Gly Thr Ala Ser Asn Ser Thr Ala Thr Asn Asp 
    130                 135                 140                 


Thr Ala Thr Asn Gly Thr Asn Thr Val Asn Ser Thr Asp Ala Thr Lys 
145                 150                 155                 160 


Thr Lys Ile Gly Asn Ser Thr Asp Asp Met Lys Lys Cys Phe Phe Asn 
                165                 170                 175     


Val Thr Thr Glu Ile Arg Asp Lys Glu Lys Lys Glu His Ala Leu Phe 
            180                 185                 190         


Tyr Lys Leu Asp Ile Val Pro Leu Gly Asn Ser Ser Arg Asn Asn Tyr 
        195                 200                 205             


Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala 
    210                 215                 220                 


Cys Pro Lys Val Asn Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro 
225                 230                 235                 240 


Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asp Glu Thr Phe Asn Gly Thr 
                245                 250                 255     


Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys 
            260                 265                 270         


Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys 
        275                 280                 285             


Glu Thr Ile Ile Arg Ser Glu Asn Leu Thr Glu Asn Thr Lys Ile Ile 
    290                 295                 300                 


Ile Val Gln Leu Asn Arg Ser Val Glu Ile Asn Cys Thr Arg Pro Gly 
305                 310                 315                 320 


Asn Asn Thr Arg Thr Ser Ile Arg Ile Gly Pro Gly Gln Ser Phe Tyr 
                325                 330                 335     


Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile 
            340                 345                 350         


Ser Ala Lys Lys Trp Asn Glu Thr Leu Gln Glu Val Gly Lys Lys Leu 
        355                 360                 365             


Gln Glu His Phe Glu Asn Lys Thr Ile Ile Phe Ala Asn Ser Ser Gly 
    370                 375                 380                 


Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
385                 390                 395                 400 


Phe Tyr Cys Asn Thr Thr Ser Leu Phe Asn Asn Ile Tyr Ser Asn Lys 
                405                 410                 415     


Thr Gly Ser Pro Asn Glu Lys Glu Ile Ile Thr Leu Pro Cys Arg Ile 
            420                 425                 430         


Lys Gln Phe Ile Asn Met Trp Gln Lys Val Gly Arg Ala Met Tyr Ala 
        435                 440                 445             


Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu 
    450                 455                 460                 


Leu Leu Leu Arg Asp Gly Gly Asn Phe Ser Arg Asp Asn Glu Thr Phe 
465                 470                 475                 480 


Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
                485                 490                 495     


Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Lys 
            500                 505                 510         


Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Ala Leu Gly Ala 
        515                 520                 525             


Val Leu Ile Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
    530                 535                 540                 


Ser Met Ala Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
545                 550                 555                 560 


Gln Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu 
                565                 570                 575     


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu 
            580                 585                 590         


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly 
        595                 600                 605             


Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser 
    610                 615                 620                 


Trp Ser Asn Asn Arg Thr His Asp Tyr Ile Trp Glu Asn Met Thr Trp 
625                 630                 635                 640 


Met Gln Trp Asp Arg Glu Val Asn Asp Tyr Thr Asp Thr Ile Tyr Arg 
                645                 650                 655     


Leu Leu Glu Lys Ser Gln Asn Gln Gln Glu Glu Asn Glu Lys Asp Leu 
            660                 665                 670         


Leu Ala Leu Asp Ser Trp Asn Ser Leu Trp Asn Trp Phe Ser Ile Thr 
        675                 680                 685             


Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu 
    690                 695                 700                 


Ile Gly Leu Arg Ile Ile Phe Thr Val Leu Ser Leu Val Asn Arg Val 
705                 710                 715                 720 


Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Ser Pro 
                725                 730                 735     


Gly Gly Pro Asp Arg Leu Glu Arg Ile Glu Glu Gly Gly Gly Glu Gln 
            740                 745                 750         


Asp Arg Ser Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ser Leu Ala 
        755                 760                 765             


Trp Glu Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg 
    770                 775                 780                 


Asp Phe Ile Leu Val Thr Ala Arg Ala Val Glu Leu Leu Gly Arg Ser 
785                 790                 795                 800 


Ser Leu Lys Gly Leu Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu Gly 
                805                 810                 815     


Ser Ile Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser 
            820                 825                 830         


Leu Leu Asp Thr Ile Ala Ile Thr Val Ala Glu Gly Thr Asp Arg Ile 
        835                 840                 845             


Ile Glu Phe Ile Gln Ser Ile Cys Arg Ala Ile Arg Asn Ile Pro Arg 
    850                 855                 860                 


Arg Ile Arg Gln Gly Phe Glu Thr Ala Leu Leu 
865                 870                 875 


<210> 261
<211> 870
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 261
Met Arg Val Met Gly Ile Ser Arg Asn Cys Gln Gln Gly Trp Ile Leu 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Leu Met Cys Asn Gly Thr Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Asn 
        35                  40                  45              


Pro Thr Pro Pro Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr 
    50                  55                  60                  


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
65                  70                  75                  80  


Asp Pro Gln Glu Leu Glu Leu Lys Asn Val Thr Glu Asp Phe Asn Met 
                85                  90                  95      


Trp Lys Asn Gly Met Val Asp Gln Met His Gln Asp Val Ile Ser Leu 
            100                 105                 110         


Trp Glu Gln Ser Leu Lys Pro Cys Val Lys Met Thr Pro Leu Cys Val 
        115                 120                 125             


Thr Leu Asn Cys Thr Tyr Val Thr Ser Lys Asn Thr Thr Asp Asn Ser 
    130                 135                 140                 


Thr Ser Thr Met Leu Leu Ser Val Asn Ala Thr Asp Ser Asp Met Lys 
145                 150                 155                 160 


Asn Cys Ser Phe Asn Val Thr Thr Glu Leu Lys Asp Lys Gln Lys Lys 
                165                 170                 175     


Val Tyr Ala Leu Phe Tyr Leu Leu Asp Ile Arg Gln Leu Asn Asp Ser 
            180                 185                 190         


Ser Asn Thr His Thr Gly Asn Ser Ser Asn Thr Gly Asn Tyr Ser Asp 
        195                 200                 205             


Tyr Ile Leu Ile Asn Cys Asn Thr Ser Thr Ile Ala Gln Ala Cys Pro 
    210                 215                 220                 


Lys Val Ser Phe Asp Pro Ile Pro Ile Pro Tyr Cys Ala Pro Ala Gly 
225                 230                 235                 240 


Tyr Ala Ile Leu Lys Cys Asn Asp Lys Asn Phe Asn Gly Thr Gly Thr 
                245                 250                 255     


Cys Thr Asn Val Ser Thr Val Gln Cys Thr Arg Gly Ile Lys Pro Val 
            260                 265                 270         


Val Ser Thr Pro Leu Leu Leu Asn Gly Ser Ile Ser Glu Gly Asp Ile 
        275                 280                 285             


Val Ile Ile Ser Lys Asn Leu Thr Asp Asn Ala Lys Thr Ile Ile Val 
    290                 295                 300                 


Gln Leu Asn Gln Thr Val Ala Val Asn Cys Thr Arg Pro Thr Asn Asn 
305                 310                 315                 320 


Thr Arg Thr Gly Ile Arg Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr 
                325                 330                 335     


Gly Asp Ile Ile Arg Asp Ile Arg Gln Ala His Cys Asn Ile Ser Gly 
            340                 345                 350         


Gly Asp Cys Asn Arg Thr Leu Glu Glu Val Glu Lys Lys Leu Asn Glu 
        355                 360                 365             


Ser Phe Ser Gly Asn Glu Thr Ile Gln Phe Glu Pro Thr Ser Gly Gly 
    370                 375                 380                 


Asp Pro Glu Ile Thr Thr Arg Ser Phe Asn Cys Gly Gly Glu Phe Phe 
385                 390                 395                 400 


Tyr Cys Lys Thr Ser Lys Leu Phe Ile Lys Thr Trp Lys Ser Trp Asn 
                405                 410                 415     


His Arg Asn Asp Gly Thr Ile Ile Thr Ile Pro Cys Arg Ile Lys Gln 
            420                 425                 430         


Ile Ile His Met Trp Gln Gly Val Gly Arg Ala Met Tyr Ala Pro Pro 
        435                 440                 445             


Ile Ser Gly Pro Ile Thr Cys Arg Ser Asn Ile Thr Gly Leu Leu Leu 
    450                 455                 460                 


Thr Arg Asp Gly Gly Ile Ser Asp Asn Asn Ser Thr Asn Thr Thr Glu 
465                 470                 475                 480 


Ile Phe Arg Arg Gln Gly Gly Asp Met Lys Asp Asn Trp Arg Ser Glu 
                485                 490                 495     


Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile Ala Pro 
            500                 505                 510         


Thr Lys Ala Lys Arg Arg Met Val Gln Arg Glu Arg Gly Glu Lys Arg 
        515                 520                 525             


His Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
    530                 535                 540                 


Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
545                 550                 555                 560 


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln 
                565                 570                 575     


Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr 
            580                 585                 590         


Arg Val Leu Ala Leu Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly 
        595                 600                 605             


Ile Trp Gly Cys Ser Gly Lys Ile Ile Cys Thr Thr Ala Val Pro Trp 
    610                 615                 620                 


Asn Ser Ser Trp Ser Asn Lys Thr His Asp Gln Ile Trp Lys Asn Met 
625                 630                 635                 640 


Thr Trp Met Gln Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Ile Ile 
                645                 650                 655     


Tyr Asn Leu Leu Glu Val Ser Gln Ile Gln Gln Glu Gln Asn Glu Gln 
            660                 665                 670         


Asp Leu Leu Ala Leu Asp Lys Trp Gln Asn Leu Trp Ser Trp Phe Asp 
        675                 680                 685             


Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly 
    690                 695                 700                 


Gly Leu Ile Gly Ile Arg Ile Ile Phe Ala Val Leu Ser Ile Val Asn 
705                 710                 715                 720 


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Ile Pro 
                725                 730                 735     


Asn Pro Arg Gly Pro Asp Arg Pro Gly Gly Ile Glu Glu Glu Gly Gly 
            740                 745                 750         


Glu Gln Asp Arg Asp Arg Ser Val Arg Leu Val Asn Gly Phe Leu Ala 
        755                 760                 765             


Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Cys Tyr His Arg 
    770                 775                 780                 


Leu Arg Asp Leu Ile Leu Ile Ala Ala Arg Val Leu Glu Leu Leu Gly 
785                 790                 795                 800 


Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu Lys Asn Ile Val Gln Tyr 
                805                 810                 815     


Trp Gly Leu Glu Leu Lys Lys Ser Ala Val Ser Leu Leu Asp Thr Val 
            820                 825                 830         


Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Val Ile Gln 
        835                 840                 845             


Arg Ala Trp Arg Ala Phe Cys Asn Ile Pro Thr Arg Ile Arg Gln Gly 
    850                 855                 860                 


Phe Glu Ile Ala Leu Leu 
865                 870 


<210> 262
<211> 844
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 262
Met Lys Val Lys Gly Thr Arg Arg Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Val Tyr Asn Val Val Gly Asn Leu Trp 
            20                  25                  30          


Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Lys Ala Thr 
        35                  40                  45              


Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val His Asn 
    50                  55                  60                  


Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Leu Glu 
65                  70                  75                  80  


Arg Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp 
                85                  90                  95      


Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Glu Ser 
            100                 105                 110         


Leu Lys Pro Cys Val Lys Leu Ile Pro Leu Cys Val Thr Leu Asn Cys 
        115                 120                 125             


Thr Thr Ala Lys Asn Lys Ser Glu Glu Met Asn Cys Ser Phe Lys Val 
    130                 135                 140                 


Thr Thr Glu Leu Arg Asp Lys Lys Arg Lys Glu Tyr Ala Leu Phe Tyr 
145                 150                 155                 160 


Arg Leu Asp Val Val Pro Leu Asn Glu Thr Asn Glu Ser Ser Asn Asp 
                165                 170                 175     


Thr Asn Gly Asp Phe Arg Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
            180                 185                 190         


Thr Leu Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile 
        195                 200                 205             


His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys 
    210                 215                 220                 


Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 
225                 230                 235                 240 


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
                245                 250                 255     


Ser Leu Ala Glu Glu Glu Ile Ile Ile Lys Ser Glu Asn Ile Thr Asp 
            260                 265                 270         


Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Lys Ala Ile Glu Ile Glu 
        275                 280                 285             


Cys Ile Arg Pro Ser Asn Asn Thr Gly Arg Ser Val Arg Ile Gly Pro 
    290                 295                 300                 


Gly Gln Thr Phe Tyr Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln 
305                 310                 315                 320 


Ala His Cys Asn Ile Ser Gly Asn Trp Asp Arg Thr Leu Tyr Asn Ile 
                325                 330                 335     


Ser Lys Lys Leu Gly Glu His Phe Pro Asn Lys Asn Ile Ser Phe Lys 
            340                 345                 350         


Pro Ser Ser Gly Gly Asp Pro Glu Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Gly Gly Glu Phe Phe Tyr Cys Asp Thr Ser Gln Leu Phe Asn Lys Thr 
    370                 375                 380                 


Tyr Asn Val Thr Asp Asp Ser Asn Thr Thr Asp Thr Asn Asn Thr Ile 
385                 390                 395                 400 


Gln Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg 
                405                 410                 415     


Ala Met Tyr Ala Pro Pro Ile Ala Gly Ser Ile Thr Cys Thr Ser Asn 
            420                 425                 430         


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Gly Gly Thr Asn Ser 
        435                 440                 445             


Thr Ser Asn Thr Glu Glu Ile Phe Arg Pro Gly Gly Gly Asn Met Lys 
    450                 455                 460                 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Val Gln 
465                 470                 475                 480 


Pro Leu Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg 
                485                 490                 495     


Glu Lys Arg Ala Ile Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Arg Gln Ile Cys 
            580                 585                 590         


Thr Thr Asn Val Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser Leu Asn 
        595                 600                 605             


Asp Ile Trp Asn Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Ser 
    610                 615                 620                 


Asn Tyr Thr Asn Ile Ile Tyr Gln Leu Leu Glu Leu Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Gln Asn Glu Lys Asp Leu Leu Ala Leu Asp Lys Trp Gln Asn 
                645                 650                 655     


Leu Trp Ser Trp Phe Asp Ile Thr His Trp Leu Trp Tyr Ile Lys Ile 
            660                 665                 670         


Phe Ile Met Ile Ile Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala 
        675                 680                 685             


Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
    690                 695                 700                 


Phe Gln Thr Leu Ile Pro Ser Gln Arg Glu Pro Asp Arg Leu Gly Arg 
705                 710                 715                 720 


Ile Glu Glu Glu Gly Gly Glu Gln Asp Lys Asp Arg Ser Ile Arg Leu 
                725                 730                 735     


Val His Gly Phe Leu Ala Ile Ala Trp Asp Asp Leu Arg Ser Leu Cys 
            740                 745                 750         


Leu Phe Ser Tyr His Arg Leu Arg Gly Phe Ile Leu Val Thr Thr Arg 
        755                 760                 765             


Val Val Gly Leu Leu Gly Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu 
    770                 775                 780                 


Gly Ser Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile 
785                 790                 795                 800 


Ser Leu Leu Asp Thr Ile Ala Ile Val Val Ala Glu Gly Thr Asp Arg 
                805                 810                 815     


Ile Ile Glu Leu Ile Leu Gly Ile Cys Arg Ala Ile Arg Asn Leu Pro 
            820                 825                 830         


Arg Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu Leu 
        835                 840                 


<210> 263
<211> 861
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 263
Met Arg Val Arg Gly Thr Gln Met Asn Cys Gln Gly Trp Trp Arg Trp 
1               5                   10                  15      


Gly Ile Met Ile Ile Gly Leu Ile Ile Ile Cys Arg Ala Lys Glu Asp 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Lys 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asp Leu Asp Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Gly Met Val Asp Gln Met His Lys Asp Ile Ile Asn Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ile Asn Ile Asn Asn Ser Thr Asp Asn Gly Thr Ser 
    130                 135                 140                 


Ile Thr Asn Glu Ile Gly Asp Glu Ile Lys Asn Cys Ser Tyr Asn Ile 
145                 150                 155                 160 


Thr Thr Glu Phe Arg Asp Lys Arg Arg Arg Val Ser Ser Leu Phe Tyr 
                165                 170                 175     


Arg His Asp Ile Met Pro Ile Asn Glu Lys Asn Asp Ser Arg Thr Tyr 
            180                 185                 190         


Ile Leu Ile Asn Cys Asn Thr Thr Thr Ile Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr 
    210                 215                 220                 


Ala Ile Leu Lys Cys Lys Asp Lys Asp Phe Asn Gly Thr Gly Pro Cys 
225                 230                 235                 240 


Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Gly Ile Lys 
            260                 265                 270         


Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys Thr Ile Ile Val Gln 
        275                 280                 285             


Leu Asp Thr Pro Val Lys Ile Asn Cys Ser Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Asp Arg Ile Gly Ile Gly Pro Gly Gln Ala Phe Phe Ala Ser Asn 
305                 310                 315                 320 


Arg Ile Ile Gly Asn Ile Arg Gln Ala His Cys Asn Ile Ser Ala Ser 
                325                 330                 335     


Ile Trp Asn Met Ile Leu Gln Lys Val Ala Glu Gln Leu Ala Lys Gln 
            340                 345                 350         


Phe Pro Asn Lys Asn Ile Ser Phe Thr Asn His Ser Gly Gly Asp Leu 
        355                 360                 365             


Glu Ile Thr Ser His Thr Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys 
    370                 375                 380                 


Asn Thr Ser Ser Leu Phe Asn Arg Thr Phe Pro Ala Asn Tyr Thr Tyr 
385                 390                 395                 400 


Asn Arg Thr Ala Asp Ser Thr Gln Gly Asn Thr Thr Ile Thr Ile Pro 
                405                 410                 415     


Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Val Gly Gln Ala 
            420                 425                 430         


Met Tyr Ala Pro Pro Ile Glu Gly Val Ile Arg Cys Glu Ser Asn Ile 
        435                 440                 445             


Thr Gly Ile Leu Leu Thr Arg Asp Gly Gly Asn Glu Thr Asn Val Glu 
    450                 455                 460                 


Val Phe Arg Pro Glu Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Asn Tyr Lys Val Val Arg Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Arg Ala Arg Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly 
            500                 505                 510         


Leu Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
        515                 520                 525             


Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ala 
    530                 535                 540                 


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Gln Ala Ile Glu Ala Gln 
545                 550                 555                 560 


Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
                565                 570                 575     


Arg Val Leu Ala Leu Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly 
            580                 585                 590         


Ile Trp Gly Cys Ser Gly Lys Thr Ile Cys Thr Thr Thr Val Pro Trp 
        595                 600                 605             


Asn Ser Ser Trp Ser Asn Lys Ser Gln Glu Glu Ile Trp Gly Asn Met 
    610                 615                 620                 


Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Asp Leu Ile 
625                 630                 635                 640 


Tyr Val Leu Leu Gln Glu Ser Gln Asn Gln Gln Asp Arg Asn Glu Gln 
                645                 650                 655     


Glu Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Asn Trp Phe Asp 
            660                 665                 670         


Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Val Val Gly 
        675                 680                 685             


Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Ile Ser Ile Val Asn 
    690                 695                 700                 


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Leu Thr Pro 
705                 710                 715                 720 


Asn Gln Glu Gly Leu Asp Arg Leu Gly Arg Ile Glu Glu Gly Gly Gly 
                725                 730                 735     


Glu Gln Gly Arg Gly Arg Ser Ile Arg Leu Val Ser Gly Phe Phe Ser 
            740                 745                 750         


Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg 
        755                 760                 765             


Leu Arg Asp Leu Val Leu Ile Ala Ala Arg Ile Val Glu Leu Leu Gly 
    770                 775                 780                 


Ser Ser Leu Leu Lys Gly Leu Arg Leu Gly Leu Glu Gly Leu Asn Tyr 
785                 790                 795                 800 


Leu Trp Asn Leu Leu Leu Tyr Trp Gly Gly Glu Leu Lys Thr Ser Ala 
                805                 810                 815     


Ile Ser Leu Phe Asp Thr Thr Ala Ile Ala Val Ala Asn Trp Thr Asp 
            820                 825                 830         


Arg Ala Ile Glu Leu Gly Gln Arg Ile Cys Arg Ala Ile Arg Asn Ile 
        835                 840                 845             


Pro Arg Arg Ile Arg Gln Gly Phe Glu Thr Ala Leu Leu 
    850                 855                 860     


<210> 264
<211> 855
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 264
Met Arg Val Arg Gly Ile Ser Arg Asn Cys Gln Gln Gly Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Trp Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Glu Ala Lys Ala Tyr Glu Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Thr Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Thr Ile Thr Gly Asp Gly Asn Asn Thr Asp Gly 
    130                 135                 140                 


Thr Asn Gly Thr Ala Arg Leu Leu Ile Tyr His Gly Asp Ile Ala Asn 
145                 150                 155                 160 


Cys Ser Phe Asn Glu Thr Thr Glu Leu Lys Asp Lys Val Ser Lys Glu 
                165                 170                 175     


His Asp Leu Phe Tyr Arg Leu Asp Val Lys Pro Leu Asn Glu Glu Lys 
            180                 185                 190         


Asn Asn Ser Thr His Asn Thr Ser Ile Leu Ile Asn Cys Ser Ser Ser 
        195                 200                 205             


Lys Val Thr His Pro Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile 
    210                 215                 220                 


Pro Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Glu Cys Arg Asp Lys 
225                 230                 235                 240 


Ala Phe Ser Gly Thr Gly Pro Trp Pro Tyr Val Tyr Thr Leu Gln Cys 
                245                 250                 255     


Pro His Gly Asn Trp Pro Val Val Ser Thr Gln Leu Leu Met Tyr Gly 
            260                 265                 270         


Phe Leu Ser Glu Asn Arg Arg Asp Asn Thr Asn Asn Ile Thr Val His 
        275                 280                 285             


Leu Ser Glu Ser Val Asp Ile Met Cys Thr Arg Pro Ser Asn Asn Thr 
    290                 295                 300                 


Arg Arg Arg Ile Ile Gly Ile Arg Pro Gly Arg Val Ser Met Met Arg 
305                 310                 315                 320 


Gly Asp Met Ile Ile Tyr Leu Arg Ala Thr Tyr Cys Asn Ile Arg Asp 
                325                 330                 335     


Thr Arg Ala Ala Cys Asn Ile Thr Leu Arg Asp Val Val Asp Glu Leu 
            340                 345                 350         


His Leu Gln Phe Asp Glu Thr Ile Thr Ile Ala Pro Ser Ser Gly Gly 
        355                 360                 365             


Pro Pro Glu Asp Asn Thr Asn Ser Ser Thr Cys Gly Glu Asp Leu Cys 
    370                 375                 380                 


Cys Cys Asn Thr Ser Gln Leu Ile His Ser Ser Ile Cys His Asn Asn 
385                 390                 395                 400 


Pro Thr Ser Glu Pro Ser Lys Asn Arg Ala Ala Asn Pro Thr Phe Ile 
                405                 410                 415     


Ile Pro Cys Arg Val Lys Gln Val Leu Ser Met Arg Leu Val Leu Arg 
            420                 425                 430         


Glu Ala Met Tyr Ala His Pro Ile Ser Gly Asp Val Leu Leu Thr Ser 
        435                 440                 445             


Asp Val Gly Gly Leu Ile Ser Thr Arg Asp Asn Ala Asn Ser Ala Asn 
    450                 455                 460                 


Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser 
465                 470                 475                 480 


Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ile Ala 
                485                 490                 495     


Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val 
            500                 505                 510         


Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Thr Ala Gly Ser Thr 
        515                 520                 525             


Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
    530                 535                 540                 


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala 
545                 550                 555                 560 


Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
                565                 570                 575     


Ala Arg Val Leu Ala Ile Glu Lys Tyr Leu Gln Asp Gln Gln Leu Leu 
            580                 585                 590         


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val Pro 
        595                 600                 605             


Trp Asn Ser Ser Trp Ser Asn Lys Ser Leu Glu Glu Ile Trp Asp Asn 
    610                 615                 620                 


Met Thr Trp Met Gln Trp Glu Arg Glu Val Gly Asn Tyr Thr Glu Ile 
625                 630                 635                 640 


Ile Tyr Lys Leu Leu Glu Asp Ser Gln Ser Gln Gln Glu Lys Asn Glu 
                645                 650                 655     


Lys Asp Leu Leu Ala Leu Asp Asn Trp Asn Asn Leu Trp Ser Trp Phe 
            660                 665                 670         


Asn Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
        675                 680                 685             


Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Met Val 
    690                 695                 700                 


Arg Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Leu Gln Thr Leu Ile 
705                 710                 715                 720 


Pro Asn Pro Arg Gly Pro Asp Arg Leu Gly Gly Ile Glu Glu Glu Gly 
                725                 730                 735     


Gly Glu Gln Asp Arg Asp Arg Ser Val Arg Leu Val Ser Gly Phe Phe 
            740                 745                 750         


Ser Leu Ala Trp Asp Asp Leu Arg Ser Leu Ile Leu Phe Leu Tyr His 
        755                 760                 765             


His Leu Arg Asp Leu Leu Leu Ile Ala Ala Arg Thr Val Glu Ile Leu 
    770                 775                 780                 


Gly Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu Val Gln 
785                 790                 795                 800 


Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Ile Ser Leu Leu Asp Thr 
                805                 810                 815     


Ile Ala Ile Ser Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Ile Val 
            820                 825                 830         


Gln Arg Ile Trp Arg Ala Ile Tyr Asn Ile Pro Arg Arg Ile Arg Gln 
        835                 840                 845             


Gly Phe Glu Ala Ala Leu Leu 
    850                 855 


<210> 265
<211> 861
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 265
Met Arg Val Lys Gly Thr Gln Gln Glu Leu Ser Thr Leu Gly Trp Ile 
1               5                   10                  15      


Trp Gly Ile Leu Gly Phe Trp Met Leu Leu Met Asn Asn Val Gly Gly 
            20                  25                  30          


Gly Lys Trp Gly Val Thr Tyr Tyr Glu Gly Val Ala Gly Arg Lys Glu 
        35                  40                  45              


Ala Thr Thr Thr Leu Cys Gly Ala Tyr Asp Ala Lys Tyr Asp Asn Asp 
    50                  55                  60                  


Val Gln His Val Gly Trp Thr Thr Ala Gly Gly Val Pro Thr His Pro 
65                  70                  75                  80  


Pro Pro Gln Glu Met Leu Leu Asn Val Val Glu Asp Phe Phe Met Met 
                85                  90                  95      


Arg Asn Asp Glu Val Glu His Met Met Asp Asp Asp Ile Ile Leu Trp 
            100                 105                 110         


Gln Arg Leu Leu Pro Cys Cys Val Thr Met Thr Leu Cys Gly Ala His 
        115                 120                 125             


Ser Thr Cys Ser Asn Ile Asn Ser Thr Ala Thr Ile Asn Asp Ser Asp 
    130                 135                 140                 


Gly Gly Met Thr Met Cys Asp Phe Ile Arg Gly Glu Ile Lys Asn Cys 
145                 150                 155                 160 


Ser Phe Asn Ile Thr Thr Asp Phe Arg Tyr Lys Leu Asp Lys Glu Pro 
                165                 170                 175     


Ala Leu Phe Tyr Lys Pro Asp Leu Val Pro Leu Asn Asn Asp Asn Ser 
            180                 185                 190         


Ser Tyr Arg Leu Thr Asn Cys Asn Thr Ser Ala Gly Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Ala Ser Phe Asp Pro Ile Pro Ala Pro Tyr Cys Ala Pro Ala 
    210                 215                 220                 


Gly Tyr Ala Ile Leu Glu Cys Asn Asn Gly Thr Phe Asn Gly Thr Arg 
225                 230                 235                 240 


Ala Cys Asn Asn Val Ser Thr Leu Glu Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Leu Val Ser Thr His Leu Leu Leu Asn Glu Asn Leu Ala Asn Asp Ile 
            260                 265                 270         


Val Ile Ile Ser Asp Asn Leu Thr Ile Ile Ala Val Ile Ile Ile Val 
        275                 280                 285             


His Leu Lys Asn Asp Gly Thr Ile Val Cys Thr Arg Thr Ser Asn Ser 
    290                 295                 300                 


Thr Arg Ile Arg Leu Arg Ile Gly Ser Gly Pro Val Cys Tyr Ala Thr 
305                 310                 315                 320 


Gly Glu Ile Ile Gln Asp Ile Arg His Ala His Asp His Ile Ser Arg 
                325                 330                 335     


Ser Asp Trp Asn Asp Ala Leu Arg Asn Val Arg Glu His Phe Arg Lys 
            340                 345                 350         


His Phe Pro Lys Phe Asn Thr Met Arg Phe Thr Gln Ser Val Gly Gly 
        355                 360                 365             


Asn Leu Gln Ile Thr Thr Arg Arg Phe Asn Cys Val Gly Glu Phe Phe 
    370                 375                 380                 


His Cys Ser Thr Thr Gly Leu Phe Thr Asp Thr Tyr Gly Thr Ser Thr 
385                 390                 395                 400 


Cys Gly Thr Asn Ser Thr Gly Asn Thr Ser Gly Ile His Thr Ile Thr 
                405                 410                 415     


Leu His Cys Lys Ile Lys Gln Phe Ile Asn Met Trp Gln Gly Val Gly 
            420                 425                 430         


Leu Ala Met Tyr Ala Pro Ser Leu Ala Gly Asn Ile Ile Cys Lys Ser 
        435                 440                 445             


Asn Phe Thr Gly Leu Val Leu Thr Cys Asp Gly Gly Glu Gly Asn Asn 
    450                 455                 460                 


Val Thr Asn Leu Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
465                 470                 475                 480 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys 
                485                 490                 495     


Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg 
            500                 505                 510         


Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
        515                 520                 525             


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
    530                 535                 540                 


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu 
545                 550                 555                 560 


Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
                565                 570                 575     


Val Lys Gln Leu Gln Ala Arg Val Leu Ala Leu Glu Arg Tyr Leu Arg 
            580                 585                 590         


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
        595                 600                 605             


Thr Thr Ala Val Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser Gln Glu 
    610                 615                 620                 


Glu Ile Trp Asn Asn Met Thr Trp Met Gln Trp Glu Lys Glu Ile Asp 
625                 630                 635                 640 


Asn Tyr Thr Asp Ile Ile Tyr Lys Leu Leu Glu Val Ser Gln Thr Gln 
                645                 650                 655     


Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Gln Asn 
            660                 665                 670         


Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile Lys Ile 
        675                 680                 685             


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala 
    690                 695                 700                 


Val Leu Ala Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
705                 710                 715                 720 


Phe Gln Thr Leu Thr Pro Ser Pro Glu Gly Pro Asp Arg Leu Arg Gly 
                725                 730                 735     


Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Thr Arg Ser Ile Arg Leu 
            740                 745                 750         


Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys 
        755                 760                 765             


Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Val Val Arg 
    770                 775                 780                 


Ala Val Glu Leu Leu Gly His Arg Gly Trp Trp Glu Thr Leu Lys His 
785                 790                 795                 800 


Leu Gly Ser Leu Glu Leu Tyr Lys Gly Val Glu Ile Lys Lys Asn Ala 
                805                 810                 815     


Ile Ser Leu Leu Lys Pro Thr Ala Thr Ala Gly Ala Glu Gly Thr Val 
            820                 825                 830         


Gln Ile Ile Glu Ile Val Leu Arg Ile Ile Arg Ser Ile Phe Asn Leu 
        835                 840                 845             


Pro Arg Arg Val Ser Gln Gly Phe Lys Ala Ala Gln Gln 
    850                 855                 860     


<210> 266
<211> 873
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 266
Met Arg Val Met Ala Ile Gln Arg Asn Cys Gln His Leu Leu Ser Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Ile Leu Met Ile Cys Ser Ala Ala Asn Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asp Pro 
65                  70                  75                  80  


Gln Glu Ile Asp Leu Lys Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr His Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Thr Ala Asn Val Asn Val Thr Asp Tyr Asn Ile Thr Thr 
    130                 135                 140                 


Gly Asp Lys Glu Glu Ile Lys Asn Cys Ser Phe Asn Met Thr Thr Glu 
145                 150                 155                 160 


Leu Ser Asp Lys Lys Gln Lys Val His Ser Leu Phe Tyr Arg Leu Asp 
                165                 170                 175     


Val Val Pro Ile Lys Pro Asp Asn Ser Asp Asp Asn Arg Ser Asn Ser 
            180                 185                 190         


Ser Tyr Ser Asn Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Asp Gly Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Lys Asn Val Ser Ser Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Gly Lys Gly Ile Arg Ile Arg Ser Glu Asn Ile Thr Asp Asn Thr Lys 
        275                 280                 285             


Thr Ile Ile Val Gln Leu Asp Lys Pro Val Arg Ile Asn Cys Thr Arg 
    290                 295                 300                 


Pro Asn Asn Asn Thr Arg Lys Ser Met Arg Ile Gly Pro Gly Gln Thr 
305                 310                 315                 320 


Phe Phe Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala His Cys 
                325                 330                 335     


Asn Ile Ser Ile Ser Glu Trp Asn Glu Thr Leu Tyr Lys Val Ala Glu 
            340                 345                 350         


Gln Leu Gly Gly Ile Ile Gly Asn Lys Thr Val Lys Phe Ala Asn Ser 
        355                 360                 365             


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Thr Thr Asp Leu Phe Lys Gly Thr Trp His 
385                 390                 395                 400 


Pro Asp Asn Lys Thr Trp Ser Asp Pro Trp Asn Ala Ser Met Lys Ser 
                405                 410                 415     


Asn Asn Thr Ser Asn Val Asn Ile Thr Ile Leu Cys Lys Ile Lys Gln 
            420                 425                 430         


Ile Val Arg Met Trp Gln Arg Val Glu Gln Ala Met Tyr Ala Pro Pro 
        435                 440                 445             


Ile Gln Gly Val Ile Ser Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu 
    450                 455                 460                 


Thr Ser Asp Gly Gly Arg Asp Asn Ser Asn Asn Thr Gly Gly Gln Lys 
465                 470                 475                 480 


Asn Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp 
                485                 490                 495     


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly 
            500                 505                 510         


Val Ala Pro Thr Pro Ala Arg Arg Arg Val Val Gln Arg Glu Lys Arg 
        515                 520                 525             


Ala Val Gly Leu Gly Ala Val Phe Ile Gly Phe Leu Gly Ala Ala Gly 
    530                 535                 540                 


Ser Thr Met Gly Ala Ala Ser Val Thr Leu Thr Val Gln Ala Arg Gln 
545                 550                 555                 560 


Leu Leu Thr Gly Ile Val Arg Gln Gln Ser Asn Leu Leu Lys Ala Ile 
                565                 570                 575     


Glu Ala Gln Gln His Leu Leu Arg Leu Thr Val Trp Gly Ile Lys Gln 
            580                 585                 590         


Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln 
        595                 600                 605             


Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn 
    610                 615                 620                 


Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Asn Gln Ser Glu Ile Trp 
625                 630                 635                 640 


Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Asn Asn Tyr Thr 
                645                 650                 655     


Gln Ile Ile Tyr Asp Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys 
            660                 665                 670         


Asn Glu Gln Glu Leu Leu Ala Leu Asp Lys Trp Thr Asn Leu Trp Asn 
        675                 680                 685             


Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met 
    690                 695                 700                 


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser 
705                 710                 715                 720 


Ile Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Ile 
                725                 730                 735     


His Asn Pro Asn Pro Gly Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu 
            740                 745                 750         


Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu Val Ser Gly 
        755                 760                 765             


Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser 
    770                 775                 780                 


Tyr His His Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu 
785                 790                 795                 800 


Ile Leu Leu Arg Arg Ala Trp Glu Gly Leu Lys Tyr Leu Trp Asn Leu 
                805                 810                 815     


Leu Leu Tyr Trp Ser Arg Glu Leu Lys Ile Ser Ala Ile Ser Leu Phe 
            820                 825                 830         


Asp Thr Ile Ala Ile Ala Val Ala Gly Trp Thr Asp Arg Val Leu Glu 
        835                 840                 845             


Ile Gly Gln Ala Ile Cys Arg Ala Ile Leu His Ile Pro Arg Arg Ile 
    850                 855                 860                 


Arg Gln Gly Leu Glu Arg Leu Leu Leu 
865                 870             


<210> 267
<211> 857
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 267
Met Met Val Met Gly Thr Leu Lys Asn Leu Ser Trp Gly Arg Ile Trp 
1               5                   10                  15      


Gly Ile Gly Phe Phe Trp Met Leu Met Ile Cys Asn Gly Glu Asp Thr 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Ala Ala Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Cys Cys Ala Tyr Asp Ala Ile Pro Tyr Glu Thr Glu Leu 
    50                  55                  60                  


His Val Gly Trp Ala Thr Pro Ala Cys Val Pro Thr Asp Pro His Pro 
65                  70                  75                  80  


Gln Glu His Val Phe Glu Asn Val Leu Glu Pro Phe Ile Met Trp Asn 
                85                  90                  95      


Asp Asp Met Glu Gln Met Met His Asp Ser Ile Ile Tyr Leu Cys His 
            100                 105                 110         


Arg Arg Leu Pro Pro Leu Val Pro Leu Cys Val Ser Gln Leu Cys His 
        115                 120                 125             


Glu Val Asp Ile Tyr Lys Asn Thr Thr Thr Ala Asn Ala Thr Ser Ser 
    130                 135                 140                 


Met Asp Val Thr Val Thr Glu Glu Leu Lys Asn Cys Ser Phe Ser Thr 
145                 150                 155                 160 


Thr Thr Asp Ile Lys Asp Lys Lys Gln Lys Ala Tyr Ala Leu Phe Tyr 
                165                 170                 175     


Lys Leu Asp Leu Ala Pro Leu Leu Ile Gly Asp Asp Ile Val Ile Asn 
            180                 185                 190         


Met Ser Cys Thr Ala Ser Thr Val Cys Arg Ala Gly Ala Phe Val Pro 
        195                 200                 205             


Phe Pro Pro Ile His Cys Ala Pro Cys Ala Pro Ala Gly Phe Ala Ser 
    210                 215                 220                 


Arg Glu Cys Lys Asp Asn Glu Val Arg Gly Thr Arg His Gly Val Thr 
225                 230                 235                 240 


Val His Arg Gly His Gly Thr His Ala Met Val Pro Ser Pro Pro Leu 
                245                 250                 255     


Leu Leu Val Gly Asn Gly Lys Gln Glu Lys Glu Asp Ile Ser Asp Lys 
            260                 265                 270         


Ser Lys Asn Tyr Ala Asn Lys Val Ile Ile Leu Leu Leu Gln Leu Arg 
        275                 280                 285             


Thr Cys Glu Glu Ile Lys Cys Thr Lys Asn Thr Thr Lys Thr Arg Arg 
    290                 295                 300                 


Ser Val Arg Arg Gly Pro Phe Phe Ala Ser Leu Glu Ile Arg Gly Glu 
305                 310                 315                 320 


Ile Arg Gln Ala Pro Arg Thr Asn Ser Ala Ser Asn Gly Ser Ala Gly 
                325                 330                 335     


Ile Thr Leu Ile Gly Glu Glu Leu Leu Gln His Leu Asp His Asn Thr 
            340                 345                 350         


Ile Arg Ser Val Pro Ser Ser Pro Cys Glu Arg Glu Thr Leu Thr His 
        355                 360                 365             


Thr Thr Pro Ser Cys Gly Trp Glu Val Phe Tyr Cys Val Ser Ile Gln 
    370                 375                 380                 


Ile Cys Asn Gly Val Tyr Phe Thr Asp Thr Trp Thr Thr Tyr Asn Ser 
385                 390                 395                 400 


Asn Asp Ala Asp Tyr Thr Asp Ile Leu Thr Leu Thr Cys Arg Ile Lys 
                405                 410                 415     


Leu Ile Val Asn Leu Ser Gln Glu Leu Gly Arg Ala Arg Ser Ala Pro 
            420                 425                 430         


Pro Ile Asp Gly Ser Val Lys Cys Thr Ser Asn Phe Thr Gly Leu Val 
        435                 440                 445             


Leu Thr Arg Ala Gly Gly Asn Ala Thr Gly Asp Val Thr Ala Glu Asn 
    450                 455                 460                 


Asn Thr Glu Ile Phe Arg Pro Gly Gly Gly Glu Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly 
                485                 490                 495     


Val Ala Pro Thr Glu Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg 
            500                 505                 510         


Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly 
        515                 520                 525             


Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln 
    530                 535                 540                 


Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile 
545                 550                 555                 560 


Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
                565                 570                 575     


Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln 
            580                 585                 590         


Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr 
        595                 600                 605             


Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Tyr Asn Glu Ile Trp 
    610                 615                 620                 


Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Asn Asn Tyr Thr 
625                 630                 635                 640 


Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys 
                645                 650                 655     


Asn Glu Arg Asp Leu Leu Ala Leu Asp Ser Trp Asn Ser Leu Trp Asn 
            660                 665                 670         


Trp Phe Ser Ile Ser Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met 
        675                 680                 685             


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ala 
    690                 695                 700                 


Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
705                 710                 715                 720 


Leu Ile Pro Asn Pro Arg Gly Pro Asp Arg Pro Gly Gly Ile Glu Glu 
                725                 730                 735     


Glu Gly Gly Glu Gln Asp Arg Gly Arg Ser Ile Arg Leu Val His Gly 
            740                 745                 750         


Phe Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Cys 
        755                 760                 765             


Tyr Arg Arg Leu Arg Asp Leu Thr Leu Ile Val Ala Arg Ala Val Glu 
    770                 775                 780                 


Leu Leu Gly Gln Arg Gly Trp Glu Ile Leu Lys Tyr Trp Gly Asn Leu 
785                 790                 795                 800 


Val Gln Tyr Trp Val Leu Gln Leu Lys Asn Ser Ala Ile Ser Leu Leu 
                805                 810                 815     


Asp Thr Val Ala Ile Pro Leu Ala Glu Gly Pro Asp Arg Ile Leu Glu 
            820                 825                 830         


Val Val Gln Arg Phe Cys Arg Ala Ile Leu Asn Ile Pro Arg Arg Ile 
        835                 840                 845             


Arg Gln Gly Phe Glu Ala Ala Leu Gln 
    850                 855         


<210> 268
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 268
Ala Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Asp 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Gly Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln His Ser Ser Ala Pro Tyr 
                85                  90                  95      


Gly Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 269
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 269
Ala Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Lys Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Cys Gly Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His His Ser Ala Pro Tyr 
                85                  90                  95      


Gly Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 270
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 270
Glu Glu Lys Leu Val Glu Ser Ser Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Thr Phe Ser Ser Val 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Ala Ile Ser Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Thr Glu Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Ser Tyr Ser Gly Trp Ser Ser Pro Tyr Gly Asp Tyr 
            100                 105                 110         


Thr Met Asp Leu Trp Gly Pro Gly Val Glu Val Val Val Ser Ser 
        115                 120                 125         


<210> 271
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 271
Glu Glu Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Thr Phe Ser Ser Thr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Ala Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Tyr 
            100                 105                 110         


Ala Met Asp Leu Trp Gly Pro Gly Val Glu Val Val Val Ser Ser 
        115                 120                 125         


