                               SEQUENCE LISTING

<110> REFUGE BIOTECHNOLOGIES, INC.
 
<120> CHIMERIC POLYPEPTIDES AND METHODS OF USING THE SAME

<130> 50489-718.601

<140> PCT/US2020/019358
<141> 2020-02-21

<150> 62/867,120
<151> 2019-06-26

<150> 62/809,477
<151> 2019-02-22

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 258
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Gly Leu Ala Leu Lys Leu Ala Gly Leu Asp Ile Glu Glu Ala Ile 
1               5                   10                  15      


Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu Pro Ile Leu Ala Met 
            20                  25                  30          


Leu Met Ala Leu Cys Val His Cys His Arg Leu Pro Gly Ser Tyr Asp 
        35                  40                  45              


Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly Ile Gln Phe Lys Arg 
    50                  55                  60                  


Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr Pro Pro Val Thr Ser 
65                  70                  75                  80  


Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro Ile Pro Arg Ser Pro 
                85                  90                  95      


Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser Ser Arg Arg Asp Ser 
            100                 105                 110         


Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu Glu Pro Ala Cys 
        115                 120                 125             


Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly Tyr Leu 
    130                 135                 140                 


Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala Pro Ser 
145                 150                 155                 160 


Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe Ser Met 
                165                 170                 175     


Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu Ser Ala 
            180                 185                 190         


Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln Glu 
        195                 200                 205             


Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser Ser Gln 
    210                 215                 220                 


Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu Asn Leu 
225                 230                 235                 240 


Gln Glu Leu Asn Ser Gly Arg Leu Gln Leu Pro Pro Leu Glu Arg Leu 
                245                 250                 255     


Thr Leu 
        


<210> 2
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Leu Ala Leu Lys Leu Ala Gly Leu Asp Ile 
1               5                   10  


<210> 3
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu 
1               5                   10      


<210> 4
<211> 262
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala Gly Trp Gly Val Trp 
        115                 120                 125             


Gly Pro Ser Trp Thr Arg Leu Thr Pro Val Ser Leu Pro Pro Glu Pro 
    130                 135                 140                 


Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly 
145                 150                 155                 160 


Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala 
                165                 170                 175     


Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe 
            180                 185                 190         


Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu 
        195                 200                 205             


Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser 
    210                 215                 220                 


Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser 
225                 230                 235                 240 


Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu 
                245                 250                 255     


Asn Leu Gln Glu Leu Asn 
            260         


<210> 5
<211> 233
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His 
        115                 120                 125             


Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser 
    130                 135                 140                 


Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp 
145                 150                 155                 160 


Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu 
                165                 170                 175     


Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val 
            180                 185                 190         


Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala 
        195                 200                 205             


Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro 
    210                 215                 220                 


Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230             


<210> 6
<211> 232
<212> PRT
<213> Homo sapiens

<400> 6
Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser Ser 
                85                  90                  95      


Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu 
            100                 105                 110         


Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn 
        115                 120                 125             


Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr 
    130                 135                 140                 


Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser 
145                 150                 155                 160 


Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser 
                165                 170                 175     


Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn 
            180                 185                 190         


Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala 
        195                 200                 205             


Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp 
    210                 215                 220                 


Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230         


<210> 7
<211> 269
<212> PRT
<213> Homo sapiens

<400> 7
Met Glu Ala Thr Ala Ala Ser Trp Gln Val Ala Val Pro Val Leu Gly 
1               5                   10                  15      


Gly Ala Ser Arg Pro Leu Gly Pro Arg Gly Ala Ala Ser Leu Leu Arg 
            20                  25                  30          


Ala Pro Leu Gln Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly 
        35                  40                  45              


Leu Leu Leu Leu Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His 
    50                  55                  60                  


Cys His Arg Leu Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu 
65                  70                  75                  80  


Tyr Pro Arg Gly Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp 
                85                  90                  95      


Pro Pro Ala Tyr Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro 
            100                 105                 110         


Asp Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His 
        115                 120                 125             


Arg Thr Pro Ser Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala 
    130                 135                 140                 


Ser Tyr Glu Asn Glu Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu 
145                 150                 155                 160 


Asp Asp Tyr His Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr 
                165                 170                 175     


Pro Ala Thr Ser Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro 
            180                 185                 190         


Gly Ile Arg Asp Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val 
        195                 200                 205             


Asn Val Pro Glu Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser 
    210                 215                 220                 


Arg Glu Tyr Val Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys 
225                 230                 235                 240 


Thr Glu Pro Ala Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu 
                245                 250                 255     


Glu Gly Ala Pro Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
            260                 265                 


<210> 8
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
ctggccctga agctggccgg cctggacatc                                        30


<210> 9
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
ctgcagctgc ctccactgga gagactgacc ctg                                    33


<210> 10
<211> 774
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atgggcctgg ccctgaagct ggccggcctg gacatcgagg aggccatcct ggtcccctgc       60

gtgctggggc tcctgctgct gcccatcctg gccatgttga tggcactgtg tgtgcactgc      120

cacagactgc caggctccta cgacagcaca tcctcagata gtttgtatcc aaggggcatc      180

cagttcaaac ggcctcacac ggttgccccc tggccacctg cctacccacc tgtcacctcc      240

tacccacccc tgagccagcc agacctgctc cccatcccaa gatccccgca gccccttggg      300

ggctcccacc ggacgccatc ttcccggcgg gattctgatg gtgccaacag tgtggcgagc      360

tacgagaacg aggaaccagc ctgtgaggat gcggatgagg atgaggacga ctatcacaac      420

ccaggctacc tggtggtgct tcctgacagc accccggcca ctagcactgc tgccccatca      480

gctcctgcac tcagcacccc tggcatccga gacagtgcct tctccatgga gtccattgat      540

gattacgtga acgttccgga gagcggggag agcgcagaag cgtctctgga tggcagccgg      600

gagtatgtga atgtgtccca ggaactgcat cctggagcgg ctaagactga gcctgccgcc      660

ctgagttccc aggaggcaga ggaagtggag gaagaggggg ctccagatta cgagaatctg      720

caggagctga acagcggccg cctgcagctg cctccactgg agagactgac cctg            774


