                               SEQUENCE LISTING

<110> MEMORIAL SLOAN KETTERING CANCER CENTER
 
<120> CD33 ANTIBODIES AND METHODS OF USING THE SAME TO TREAT CANCER

<130> 115872-0653

<140> PCT/US2020/019351
<141> 2020-02-21

<150> 62/809,091
<151> 2019-02-22

<160> 167   

<170> PatentIn version 3.5

<210> 1
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Ser Val Thr Val Ser Ser 
        115                 


<210> 2
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Ser Val Thr Val Ser Ser 
        115                 


<210> 3
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Ser Val Thr Val Ser Ser 
        115                 


<210> 4
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Ser Val Thr Val Ser Ser 
        115                 


<210> 5
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Ser Val Thr Val Ser Ser 
        115                 


<210> 6
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Ser Val Thr Val Ser Ser 
        115                 


<210> 7
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Ser Val Thr Val Ser Ser 
        115                 


<210> 8
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210> 9
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210> 10
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210> 11
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210> 12
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210> 13
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Gln Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210> 14
<211> 505
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn 
                85                  90                  95      


Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
                245                 250                 255     


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys 
            260                 265                 270         


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
    290                 295                 300                 


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg 
                325                 330                 335     


Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His 
            340                 345                 350         


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
385                 390                 395                 400 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                405                 410                 415     


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            420                 425                 430         


Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
        435                 440                 445             


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
465                 470                 475                 480 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
                485                 490                 495     


Cys Gly Thr Lys Leu Gln Ile Thr Arg 
            500                 505 


<210> 15
<211> 1518
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggcgt gcacagcgac       60

atcgtcatga ctcagagccc tagcagcctg agcgcatccc tgggaggaaa ggtcactatc      120

acttgtaaag catcacagga catcaacaag tacatcgcct ggtatcagca caagccaggc      180

aaaggccccc ggctgctgat ccactacacc agcacactgc agccaggcat cccttcccgg      240

ttcagcggct ccggctctgg aagagactac agcttttcca tctctaatct ggagcccgag      300

gatatcgcca cctattattg tctgcagtat gataatctgc tgacatttgg cgctggaact      360

aagctggaac tgaaacggac cgtggccgcc ccctccgtgt tcatcttccc cccctccgac      420

gagcagctga agtccggcac cgcctccgtg gtgtgcctgc tgaacaactt ctacccccgg      480

gaggccaagg tgcagtggaa ggtggacaac gccctgcagt ccggcaactc ccaggagtcc      540

gtgaccgagc aggactccaa ggactccacc tactccctgt cctccaccct gaccctgtcc      600

aaggccgact acgagaagca caaggtgtac gcctgcgagg tgacccacca gggcctgtcc      660

tcccccgtga ccaagtcctt caaccggggc gagtgcacta gtggcggcgg aggatctggc      720

ggaggtggaa gcggaggggg aggatctcag gtgcagctgg tgcagagcgg aggcggagtg      780

gtgcagcctg gcagatccct gagactgtcc tgcaaggcct ccggctacac cttcacccgg      840

tacaccatgc actgggtgcg acaggcccct ggcaagtgcc tggaatggat cggctacatc      900

aacccctccc ggggctacac caactacaac cagaagttca aggaccggtt caccatctcc      960

cgggacaact ccaagaacac cgcctttctg cagatggact ccctgcggcc tgaggatacc     1020

ggcgtgtact tctgcgcccg gtactacgac gaccactact ccctggacta ctggggccag     1080

ggaacccctg tgacagtgtc atctggtggc ggaggaagtg ggggaggcgg atcaggtggt     1140

ggtggatcag gcgggggagg ttcagggggt ggcggttctg ggggaggggg ctctgatatt     1200

cagatgactc agagcccttc cagcctgagc gcctccgtgg gagatcgcgt gacaattacc     1260

tgctctgcct cctcctccgt gtcttacatg aattggtatc agcagacccc tgggaaggct     1320

cctaagcggt ggatctacga cacctccaag ctggcctctg gcgtgcccag caggttttct     1380

ggctccggca gcggcacaga ttataccttc accatcagct ccctgcagcc agaagatatc     1440

gctacctatt attgtcagca gtggtcctcc aaccctttca ccttcggctg cggcacaaag     1500

ctgcagatca caagatag                                                   1518


<210> 16
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210> 17
<211> 1407
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggcgt gcacagcgaa       60

gtgaaactgc agcagagcgg ccctgaactg gtcaaacctg gaacctccgt gaaagtgtct      120

tgtaaagcat ccgggtactc attcaccgac tacaacatgt attgggtgaa gcagagccac      180

ggcaagtccc tggagtggat cggctacatc gacccctata agggcggcac aatctacaac      240

cagaagttca agggcaaggc caccctgaca gtggacaaga gctcctctac cgcctttatg      300

cacctgaata gcctgacatc cgaggattct gccgtgtact attgcgcccg ggagatgatt      360

acagcctact actttgatta ctggggacag gggtcttccg tcaccgtctc ctctgcctcc      420

accaagggcc cctctgtgtt tcctctggcc ccctccagca agtccacctc tggtggaaca      480

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      540

tctggcgctc tgacctctgg cgtgcacacc ttccctgctg tgctgcagtc tagcggcctg      600

tactccctgt cctccgtcgt gacagtgccc tccagctctc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc ctccaatacc aaggtggaca agcgggtgga acccaagtcc      720

tgcgacaaga cccacacctg tcccccttgt cctgcccctg aactgctggg cggaccttcc      780

gtgttcctgt tccccccaaa gcccaaggac accctgatga tctcccggac ccccgaagtg      840

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg      900

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta cgcctccacc      960

taccgggtgg tgtccgtgct gacagtgctg caccaggact ggctgaacgg caaagagtac     1020

aagtgcgccg tgtccaacaa ggccctgcct gcccccatcg aaaagaccat ctccaaggcc     1080

aagggccagc cccgggaacc ccaggtgtac acactgcccc ctagcaggga cgagctgacc     1140

aagaaccagg tgtccctgac ctgtctcgtg aaaggcttct acccctccga tatcgccgtg     1200

gaatgggagt ccaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1260

tccgacggct cattcttcct gtacagcaag ctgaccgtgg acaagtcccg gtggcagcag     1320

ggcaacgtgt tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

tccctgtccc tgagccccgg caaatga                                         1407


<210> 18
<211> 505
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
                245                 250                 255     


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys 
            260                 265                 270         


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
    290                 295                 300                 


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg 
                325                 330                 335     


Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His 
            340                 345                 350         


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
385                 390                 395                 400 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                405                 410                 415     


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            420                 425                 430         


Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
        435                 440                 445             


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
465                 470                 475                 480 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
                485                 490                 495     


Cys Gly Thr Lys Leu Gln Ile Thr Arg 
            500                 505 


<210> 19
<211> 1518
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggcgt gcacagcgac       60

atccagatga cccagtcccc aagctccctg tccgcctctg tgggcgaccg ggtgaccatc      120

acatgcaagg cctcccagga tatcaacaag tacatcgcct ggtatcagca caagcccggc      180

aaggccccta agctgctgat ccactacacc tctacactgg agaccggcgt gccaagcaga      240

ttcagcggct ccggctctgg cacagatttc acctttacaa tctctagcct gcagcccgag      300

gacatcgcca catactattg tctgcagtat gataatctgc tgacctttgg cgccggcaca      360

aagctggagc tgaagcggac cgtggccgcc ccctccgtgt tcatcttccc cccctccgac      420

gagcagctga agtccggcac cgcctccgtg gtgtgcctgc tgaacaactt ctacccccgg      480

gaggccaagg tgcagtggaa ggtggacaac gccctgcagt ccggcaactc ccaggagtcc      540

gtgaccgagc aggactccaa ggactccacc tactccctgt cctccaccct gaccctgtcc      600

aaggccgact acgagaagca caaggtgtac gcctgcgagg tgacccacca gggcctgtcc      660

tcccccgtga ccaagtcctt caaccggggc gagtgcacta gtggcggcgg aggatctggc      720

ggaggtggaa gcggaggggg aggatctcag gtgcagctgg tgcagagcgg aggcggagtg      780

gtgcagcctg gcagatccct gagactgtcc tgcaaggcct ccggctacac cttcacccgg      840

tacaccatgc actgggtgcg acaggcccct ggcaagtgcc tggaatggat cggctacatc      900

aacccctccc ggggctacac caactacaac cagaagttca aggaccggtt caccatctcc      960

cgggacaact ccaagaacac cgcctttctg cagatggact ccctgcggcc tgaggatacc     1020

ggcgtgtact tctgcgcccg gtactacgac gaccactact ccctggacta ctggggccag     1080

ggaacccctg tgacagtgtc atctggtggc ggaggaagtg ggggaggcgg atcaggtggt     1140

ggtggatcag gcgggggagg ttcagggggt ggcggttctg ggggaggggg ctctgatatt     1200

cagatgactc agagcccttc cagcctgagc gcctccgtgg gagatcgcgt gacaattacc     1260

tgctctgcct cctcctccgt gtcttacatg aattggtatc agcagacccc tgggaaggct     1320

cctaagcggt ggatctacga cacctccaag ctggcctctg gcgtgcccag caggttttct     1380

ggctccggca gcggcacaga ttataccttc accatcagct ccctgcagcc agaagatatc     1440

gctacctatt attgtcagca gtggtcctcc aaccctttca ccttcggctg cggcacaaag     1500

ctgcagatca caagatag                                                   1518


<210> 20
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210> 21
<211> 1407
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggcgt gcacagccag       60

gtgcagctgc agcagtccgg agcagaggtg gtgaagccag gagcctctgt gaaggtgagc      120

tgcaaggcca gcggctactc cttcaccgac tacaacatgt attgggtgcg gcaggcacca      180

ggacagggcc tggagtggat gggctacatc gacccttata agggcggcac aatctacaat      240

cagaagtttc agggaagggc caccctgaca agggacacct ccatctctac agcctatatg      300

gagctgtccc ggctgagatc tgacgatacc gccgtgtact attgtgccag ggagatgatc      360

acagcctact atttcgatta ttggggccag ggcagctccg tgaccgtgtc tagcgcctcc      420

accaagggcc cctctgtgtt tcctctggcc ccctccagca agtccacctc tggtggaaca      480

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      540

tctggcgctc tgacctctgg cgtgcacacc ttccctgctg tgctgcagtc tagcggcctg      600

tactccctgt cctccgtcgt gacagtgccc tccagctctc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc ctccaatacc aaggtggaca agcgggtgga acccaagtcc      720

tgcgacaaga cccacacctg tcccccttgt cctgcccctg aactgctggg cggaccttcc      780

gtgttcctgt tccccccaaa gcccaaggac accctgatga tctcccggac ccccgaagtg      840

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg      900

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta cgcctccacc      960

taccgggtgg tgtccgtgct gacagtgctg caccaggact ggctgaacgg caaagagtac     1020

aagtgcgccg tgtccaacaa ggccctgcct gcccccatcg aaaagaccat ctccaaggcc     1080

aagggccagc cccgggaacc ccaggtgtac acactgcccc ctagcaggga cgagctgacc     1140

aagaaccagg tgtccctgac ctgtctcgtg aaaggcttct acccctccga tatcgccgtg     1200

gaatgggagt ccaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1260

tccgacggct cattcttcct gtacagcaag ctgaccgtgg acaagtcccg gtggcagcag     1320

ggcaacgtgt tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

tccctgtccc tgagccccgg caaatga                                         1407


<210> 22
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210> 23
<211> 1407
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggcgt gcacagccag       60

gtgcagctgc agcagtccgg agcagaggtg aagaagccag gagcctctgt gaaggtgagc      120

tgcaaggcca gcggctactc cttcaccgac tacaacatgt attgggtgcg gcaggcacca      180

ggacagggcc tggagtggat gggctacatc gacccttata agggcggcac aatctacaat      240

cagaagttta agggaagggc caccctgaca agggacacct ccatctctac agcctatatg      300

gagctgtccc ggctgagatc tgacgatacc gccgtgtact attgtgccag ggagatgatc      360

acagcctact atttcgatta ttggggccag ggcagctccg tgaccgtgtc tagcgcctcc      420

accaagggcc cctctgtgtt tcctctggcc ccctccagca agtccacctc tggtggaaca      480

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      540

tctggcgctc tgacctctgg cgtgcacacc ttccctgctg tgctgcagtc tagcggcctg      600

tactccctgt cctccgtcgt gacagtgccc tccagctctc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc ctccaatacc aaggtggaca agcgggtgga acccaagtcc      720

tgcgacaaga cccacacctg tcccccttgt cctgcccctg aactgctggg cggaccttcc      780

gtgttcctgt tccccccaaa gcccaaggac accctgatga tctcccggac ccccgaagtg      840

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg      900

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta cgcctccacc      960

taccgggtgg tgtccgtgct gacagtgctg caccaggact ggctgaacgg caaagagtac     1020

aagtgcgccg tgtccaacaa ggccctgcct gcccccatcg aaaagaccat ctccaaggcc     1080

aagggccagc cccgggaacc ccaggtgtac acactgcccc ctagcaggga cgagctgacc     1140

aagaaccagg tgtccctgac ctgtctcgtg aaaggcttct acccctccga tatcgccgtg     1200

gaatgggagt ccaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1260

tccgacggct cattcttcct gtacagcaag ctgaccgtgg acaagtcccg gtggcagcag     1320

ggcaacgtgt tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

tccctgtccc tgagccccgg caaatga                                         1407


<210> 24
<211> 505
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
                245                 250                 255     


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys 
            260                 265                 270         


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
    290                 295                 300                 


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg 
                325                 330                 335     


Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His 
            340                 345                 350         


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
385                 390                 395                 400 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                405                 410                 415     


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            420                 425                 430         


Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
        435                 440                 445             


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
465                 470                 475                 480 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
                485                 490                 495     


Cys Gly Thr Lys Leu Gln Ile Thr Arg 
            500                 505 


<210> 25
<211> 1518
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggcgt gcacagcgac       60

atccagatga cccagtcccc tagctccctg tccgcctctg tgggcgacag ggtgaccatc      120

acatgcaagg cctcccagga tatcaacaag tacatcgcct ggtatcagca caagccaggc      180

aaggccccca agctgctgat ctactatgcc tctaatctgc agccaggagt gcctagccgg      240

ttcagcggct ccggctctgg aagagatttc acctttacaa tctctagcct gcagcccgag      300

gacatcgcca catactattg tctgcagtac gataacctgc tgacctttgg cgccggcaca      360

aagctggagc tgaagcggac cgtggccgcc ccctccgtgt tcatcttccc cccctccgac      420

gagcagctga agtccggcac cgcctccgtg gtgtgcctgc tgaacaactt ctacccccgg      480

gaggccaagg tgcagtggaa ggtggacaac gccctgcagt ccggcaactc ccaggagtcc      540

gtgaccgagc aggactccaa ggactccacc tactccctgt cctccaccct gaccctgtcc      600

aaggccgact acgagaagca caaggtgtac gcctgcgagg tgacccacca gggcctgtcc      660

tcccccgtga ccaagtcctt caaccggggc gagtgcacta gtggcggcgg aggatctggc      720

ggaggtggaa gcggaggggg aggatctcag gtgcagctgg tgcagagcgg aggcggagtg      780

gtgcagcctg gcagatccct gagactgtcc tgcaaggcct ccggctacac cttcacccgg      840

tacaccatgc actgggtgcg acaggcccct ggcaagtgcc tggaatggat cggctacatc      900

aacccctccc ggggctacac caactacaac cagaagttca aggaccggtt caccatctcc      960

cgggacaact ccaagaacac cgcctttctg cagatggact ccctgcggcc tgaggatacc     1020

ggcgtgtact tctgcgcccg gtactacgac gaccactact ccctggacta ctggggccag     1080

ggaacccctg tgacagtgtc atctggtggc ggaggaagtg ggggaggcgg atcaggtggt     1140

ggtggatcag gcgggggagg ttcagggggt ggcggttctg ggggaggggg ctctgatatt     1200

cagatgactc agagcccttc cagcctgagc gcctccgtgg gagatcgcgt gacaattacc     1260

tgctctgcct cctcctccgt gtcttacatg aattggtatc agcagacccc tgggaaggct     1320

cctaagcggt ggatctacga cacctccaag ctggcctctg gcgtgcccag caggttttct     1380

ggctccggca gcggcacaga ttataccttc accatcagct ccctgcagcc agaagatatc     1440

gctacctatt attgtcagca gtggtcctcc aaccctttca ccttcggctg cggcacaaag     1500

ctgcagatca caagatag                                                   1518


<210> 26
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Lys Leu Gln Glu Ser 
                245                 250                 255     


Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu Ser Leu Thr Cys Thr 
            260                 265                 270         


Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
        275                 280                 285             


Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
    290                 295                 300                 


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Leu Asn Ile Tyr Arg 
305                 310                 315                 320 


Asp Asn Ser Lys Asn Gln Val Phe Leu Glu Met Asn Ser Leu Gln Ala 
                325                 330                 335     


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
            340                 345                 350         


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Thr Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
385                 390                 395                 400 


Val Val Ile Gln Glu Ser Ala Leu Thr Thr Pro Pro Gly Glu Thr Val 
                405                 410                 415     


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
            420                 425                 430         


Ala Asn Trp Val Gln Glu Lys Pro Asp His Cys Phe Thr Gly Leu Ile 
        435                 440                 445             


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
    450                 455                 460                 


Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Ala Gly Thr Gln Thr 
465                 470                 475                 480 


Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asp His Trp 
                485                 490                 495     


Val Ile Gly Gly Gly Thr Arg Leu Thr Val Leu Gly 
            500                 505             


<210> 27
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
    290                 295                 300                 


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
            340                 345                 350         


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
385                 390                 395                 400 


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
                405                 410                 415     


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
            420                 425                 430         


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
        435                 440                 445             


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
    450                 455                 460                 


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
465                 470                 475                 480 


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
                485                 490                 495     


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505             


<210> 28
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Lys Leu Gln Glu Ser 
                245                 250                 255     


Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu Ser Leu Thr Cys Thr 
            260                 265                 270         


Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
        275                 280                 285             


Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
    290                 295                 300                 


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Leu Asn Ile Tyr Arg 
305                 310                 315                 320 


Asp Asn Ser Lys Asn Gln Val Phe Leu Glu Met Asn Ser Leu Gln Ala 
                325                 330                 335     


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
            340                 345                 350         


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Thr Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
385                 390                 395                 400 


Val Val Ile Gln Glu Ser Ala Leu Thr Thr Pro Pro Gly Glu Thr Val 
                405                 410                 415     


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
            420                 425                 430         


Ala Asn Trp Val Gln Glu Lys Pro Asp His Cys Phe Thr Gly Leu Ile 
        435                 440                 445             


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
    450                 455                 460                 


Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Ala Gly Thr Gln Thr 
465                 470                 475                 480 


Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asp His Trp 
                485                 490                 495     


Val Ile Gly Gly Gly Thr Arg Leu Thr Val Leu Gly 
            500                 505             


<210> 29
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
    290                 295                 300                 


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
            340                 345                 350         


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
385                 390                 395                 400 


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
                405                 410                 415     


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
            420                 425                 430         


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
        435                 440                 445             


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
    450                 455                 460                 


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
465                 470                 475                 480 


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
                485                 490                 495     


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505             


<210> 30
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 31
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 32
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 33
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 34
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 35
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 36
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 37
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 38
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 39
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 40
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 41
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 42
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 43
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 44
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 45
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 46
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 47
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 48
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 49
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 50
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 51
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 52
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 53
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 54
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 55
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 56
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 57
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 58
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 59
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 60
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 61
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 62
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 63
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 64
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 65
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 66
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 67
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 68
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 69
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 70
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 71
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 72
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 73
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 74
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 75
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 76
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 77
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 78
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
    210                 215                 220                 


Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 79
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
    210                 215                 220                 


Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 80
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 81
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 82
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
    210                 215                 220                 


Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 83
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
    210                 215                 220                 


Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 84
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 85
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 86
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 86
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
    210                 215                 220                 


Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 87
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
    210                 215                 220                 


Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 88
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 89
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 90
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 91
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 92
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 93
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 93
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 94
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 95
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 95
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 96
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 97
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 97
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 98
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 99
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 99
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 100
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 100
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 101
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 101
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 102
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 102
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 103
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 103
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 104
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 104
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 105
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 105
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 106
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 106
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 107
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 107
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 108
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 108
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 109
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 109
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 110
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 110
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 111
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 111
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
225                 230                 235                 240 


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 112
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 112
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 113
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 113
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Glu Thr 
    210                 215                 220                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 114
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 114
Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Ser Val Thr Val Ser Ser 
        115                 


<210> 115
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 115
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210> 116
<211> 384
<212> PRT
<213> Homo sapiens

<400> 116
Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg 
1               5                   10                  15      


His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly 
            20                  25                  30          


Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser 
        35                  40                  45              


Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr 
    50                  55                  60                  


Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly 
65                  70                  75                  80  


Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu 
                85                  90                  95      


Ile Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro 
            100                 105                 110         


Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala 
        115                 120                 125             


Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys 
    130                 135                 140                 


Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu 
145                 150                 155                 160 


Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala 
                165                 170                 175     


Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val 
            180                 185                 190         


Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly 
        195                 200                 205             


Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser 
    210                 215                 220                 


Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu 
225                 230                 235                 240 


Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu 
                245                 250                 255     


Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro 
            260                 265                 270         


Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala 
        275                 280                 285             


Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile 
    290                 295                 300                 


Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe 
305                 310                 315                 320 


Ala Pro Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala 
                325                 330                 335     


Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr 
            340                 345                 350         


Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala 
        355                 360                 365             


Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380                 


<210> 117
<211> 330
<212> PRT
<213> Homo sapiens

<400> 117
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 118
<211> 326
<212> PRT
<213> Homo sapiens

<400> 118
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210> 119
<211> 377
<212> PRT
<213> Homo sapiens

<400> 119
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 120
<211> 452
<212> PRT
<213> Homo sapiens

<400> 120
Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 
                405                 410                 415     


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
            420                 425                 430         


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
        435                 440                 445             


Gly Thr Cys Tyr 
    450         


<210> 121
<211> 327
<212> PRT
<213> Homo sapiens

<400> 121
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210> 122
<211> 353
<212> PRT
<213> Homo sapiens

<400> 122
Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210> 123
<211> 340
<212> PRT
<213> Homo sapiens

<400> 123
Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210> 124
<211> 106
<212> PRT
<213> Homo sapiens

<400> 124
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210> 125
<211> 39
<212> PRT
<213> Homo sapiens

<400> 125
Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
1               5                   10                  15      


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            20                  25                  30          


Ala Gln Ala Gly Lys Glu Pro 
        35                  


<210> 126
<211> 57
<212> PRT
<213> Homo sapiens

<400> 126
Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro Val Arg Gly Arg Glu 
1               5                   10                  15      


Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser Leu Glu Leu Met Gln 
            20                  25                  30          


Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln His Gln His Leu Leu Gln Lys Gln 
    50                  55          


<210> 127
<211> 52
<212> PRT
<213> Homo sapiens

<400> 127
Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu 
1               5                   10                  15      


Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu 
            20                  25                  30          


Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu 
        35                  40                  45              


Leu Gln Arg Pro 
    50          


<210> 128
<211> 27
<212> PRT
<213> Homo sapiens

<400> 128
Gln Ala Ile Lys Lys Glu Leu Thr Gln Ile Lys Gln Lys Val Asp Ser 
1               5                   10                  15      


Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu 
            20                  25          


<210> 129
<211> 54
<212> PRT
<213> Homo sapiens

<400> 129
Ser Thr Arg Arg Ile Leu Gly Leu Ala Ile Glu Ser Gln Asp Ala Gly 
1               5                   10                  15      


Ile Lys Thr Ile Thr Met Leu Asp Glu Gln Lys Glu Gln Leu Asn Arg 
            20                  25                  30          


Ile Glu Glu Gly Leu Asp Gln Ile Asn Lys Asp Met Arg Glu Thr Glu 
        35                  40                  45              


Lys Thr Leu Thr Glu Leu 
    50                  


<210> 130
<211> 97
<212> PRT
<213> Homo sapiens

<400> 130
Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr Gln 
1               5                   10                  15      


His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn Lys 
            20                  25                  30          


Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val Ala 
        35                  40                  45              


Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe Val 
    50                  55                  60                  


His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu Thr 
65                  70                  75                  80  


Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr Tyr 
                85                  90                  95      


Phe 
    


<210> 131
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      KCNQ4 sequence

<400> 131
Asp Glu Ile Ser Met Met Gly Arg Val Val Lys Val Glu Lys Gln Val 
1               5                   10                  15      


Gln Ser Ile Glu His Lys Leu Asp Leu Leu Leu Gly Phe Tyr 
            20                  25                  30  


<210> 132
<211> 60
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CBFA2T1 sequence

<400> 132
Thr Val Ala Glu Ala Lys Arg Gln Ala Ala Glu Asp Ala Leu Ala Val 
1               5                   10                  15      


Ile Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg 
            20                  25                  30          


Lys Ala Ser Glu Thr Cys Ser Gly Cys Asn Thr Ala Arg Tyr Cys Gly 
        35                  40                  45              


Ser Phe Cys Gln His Lys Asp Trp Glu Lys His His 
    50                  55                  60  


<210> 133
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 133
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Ser Val Thr Val Ser Ser 
        115                 


<210> 134
<211> 505
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 134
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
                245                 250                 255     


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys 
            260                 265                 270         


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
    290                 295                 300                 


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg 
                325                 330                 335     


Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His 
            340                 345                 350         


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
385                 390                 395                 400 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                405                 410                 415     


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            420                 425                 430         


Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
        435                 440                 445             


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
465                 470                 475                 480 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
                485                 490                 495     


Cys Gly Thr Lys Leu Gln Ile Thr Arg 
            500                 505 


<210> 135
<211> 1518
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 135
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggcgt gcacagcgac       60

atccagatga cccagtcccc tagctccctg tccgcctctg tgggcgacag ggtgaccatc      120

acatgcaagg cctcccagga tatcaacaag tacatcgcct ggtatcagca caagccaggc      180

aaggccccca agctgctgat ctactatgcc tctaatctgc agccaggagt gcctagccgg      240

ttcagcggct ccggctctgg aagagatttc acctttacaa tctctagcct gcagcccgag      300

gacatcgcca catactattg tctgcagtac gataacctgc tgacctttgg cgccggcaca      360

aagctggagc tgaagcggac cgtggccgcc ccctccgtgt tcatcttccc cccctccgac      420

gagcagctga agtccggcac cgcctccgtg gtgtgcctgc tgaacaactt ctacccccgg      480

gaggccaagg tgcagtggaa ggtggacaac gccctgcagt ccggcaactc ccaggagtcc      540

gtgaccgagc aggactccaa ggactccacc tactccctgt cctccaccct gaccctgtcc      600

aaggccgact acgagaagca caaggtgtac gcctgcgagg tgacccacca gggcctgtcc      660

tcccccgtga ccaagtcctt caaccggggc gagtgcacta gtggcggcgg aggatctggc      720

ggaggtggaa gcggaggggg aggatctcag gtgcagctgg tgcagagcgg aggcggagtg      780

gtgcagcctg gcagatccct gagactgtcc tgcaaggcct ccggctacac cttcacccgg      840

tacaccatgc actgggtgcg acaggcccct ggcaagtgcc tggaatggat cggctacatc      900

aacccctccc ggggctacac caactacaac cagaagttca aggaccggtt caccatctcc      960

cgggacaact ccaagaacac cgcctttctg cagatggact ccctgcggcc tgaggatacc     1020

ggcgtgtact tctgcgcccg gtactacgac gaccactact ccctggacta ctggggccag     1080

ggaacccctg tgacagtgtc atctggtggc ggaggaagtg ggggaggcgg atcaggtggt     1140

ggtggatcag gcgggggagg ttcagggggt ggcggttctg ggggaggggg ctctgatatt     1200

cagatgactc agagcccttc cagcctgagc gcctccgtgg gagatcgcgt gacaattacc     1260

tgctctgcct cctcctccgt gtcttacatg aattggtatc agcagacccc tgggaaggct     1320

cctaagcggt ggatctacga cacctccaag ctggcctctg gcgtgcccag caggttttct     1380

ggctccggca gcggcacaga ttataccttc accatcagct ccctgcagcc agaagatatc     1440

gctacctatt attgtcagca gtggtcctcc aaccctttca ccttcggctg cggcacaaag     1500

ctgcagatca caagatag                                                   1518


<210> 136
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 136
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210> 137
<211> 1407
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 137
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggcgt gcacagccag       60

gtgcagctgc agcagtccgg agcagaggtg gtgaagccag gagcctctgt gaaggtgagc      120

tgcaaggcca gcggctactc cttcaccgac tacaacatgt attgggtgcg gcaggcacca      180

ggacagggcc tggagtggat gggctacatc gacccttata agggcggcac aatctacaat      240

cagaagtttc agggaagggc caccctgaca agggacacct ccatctctac agcctatatg      300

gagctgtccc ggctgagatc tgacgatacc gccgtgtact attgtgccag ggagatgatc      360

acagcctact atttcgatta ttggggccag ggcagctccg tgaccgtgtc tagcgcctcc      420

accaagggcc cctctgtgtt tcctctggcc ccctccagca agtccacctc tggtggaaca      480

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      540

tctggcgctc tgacctctgg cgtgcacacc ttccctgctg tgctgcagtc tagcggcctg      600

tactccctgt cctccgtcgt gacagtgccc tccagctctc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc ctccaatacc aaggtggaca agcgggtgga acccaagtcc      720

tgcgacaaga cccacacctg tcccccttgt cctgcccctg aactgctggg cggaccttcc      780

gtgttcctgt tccccccaaa gcccaaggac accctgatga tctcccggac ccccgaagtg      840

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg      900

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta cgcctccacc      960

taccgggtgg tgtccgtgct gacagtgctg caccaggact ggctgaacgg caaagagtac     1020

aagtgcgccg tgtccaacaa ggccctgcct gcccccatcg aaaagaccat ctccaaggcc     1080

aagggccagc cccgggaacc ccaggtgtac acactgcccc ctagcaggga cgagctgacc     1140

aagaaccagg tgtccctgac ctgtctcgtg aaaggcttct acccctccga tatcgccgtg     1200

gaatgggagt ccaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1260

tccgacggct cattcttcct gtacagcaag ctgaccgtgg acaagtcccg gtggcagcag     1320

ggcaacgtgt tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

tccctgtccc tgagccccgg caaatga                                         1407


<210> 138
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 138
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn 
                85                  90                  95      


Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Lys Leu Gln Glu Ser 
                245                 250                 255     


Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu Ser Leu Thr Cys Thr 
            260                 265                 270         


Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
        275                 280                 285             


Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
    290                 295                 300                 


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Leu Asn Ile Tyr Arg 
305                 310                 315                 320 


Asp Asn Ser Lys Asn Gln Val Phe Leu Glu Met Asn Ser Leu Gln Ala 
                325                 330                 335     


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
            340                 345                 350         


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Thr Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
385                 390                 395                 400 


Val Val Ile Gln Glu Ser Ala Leu Thr Thr Pro Pro Gly Glu Thr Val 
                405                 410                 415     


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
            420                 425                 430         


Ala Asn Trp Val Gln Glu Lys Pro Asp His Cys Phe Thr Gly Leu Ile 
        435                 440                 445             


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
    450                 455                 460                 


Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Ala Gly Thr Gln Thr 
465                 470                 475                 480 


Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asp His Trp 
                485                 490                 495     


Val Ile Gly Gly Gly Thr Arg Leu Thr Val Leu Gly 
            500                 505             


<210> 139
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 139
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210> 140
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 140
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn 
                85                  90                  95      


Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
    290                 295                 300                 


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
            340                 345                 350         


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
385                 390                 395                 400 


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
                405                 410                 415     


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
            420                 425                 430         


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
        435                 440                 445             


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
    450                 455                 460                 


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
465                 470                 475                 480 


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
                485                 490                 495     


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505             


<210> 141
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 141
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210> 142
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 142
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn 
                85                  90                  95      


Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe Met His Leu Asn 
225                 230                 235                 240 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 143
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 143
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn 
                85                  90                  95      


Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe Met His Leu Asn 
225                 230                 235                 240 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 144
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 144
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro 
    210                 215                 220                 


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser 
225                 230                 235                 240 


Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala Pro His His His His His His 
    610                 615         


<210> 145
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 145
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro 
    210                 215                 220                 


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser 
225                 230                 235                 240 


Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
                565                 570                 575     


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
            580                 585                 590         


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
        595                 600                 605             


Gly Ala 
    610 


<210> 146
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 146
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn 
                85                  90                  95      


Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe Met His Leu Asn 
225                 230                 235                 240 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 147
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 147
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn 
                85                  90                  95      


Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe Met His Leu Asn 
225                 230                 235                 240 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 148
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 148
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro 
    210                 215                 220                 


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser 
225                 230                 235                 240 


Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635 


<210> 149
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 149
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro 
    210                 215                 220                 


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser 
225                 230                 235                 240 


Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro 
                565                 570                 575     


Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ala 
625             


<210> 150
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 150
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn 
                85                  90                  95      


Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe Met His Leu Asn 
225                 230                 235                 240 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 151
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 151
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg 
    50                  55                  60                  


Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn 
                85                  90                  95      


Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn 
            100                 105                 110         


Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser Val Lys Val 
                165                 170                 175     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Asn Met Tyr Trp 
            180                 185                 190         


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Tyr Ile Asp 
        195                 200                 205             


Pro Tyr Lys Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
    210                 215                 220                 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe Met His Leu Asn 
225                 230                 235                 240 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Met 
                245                 250                 255     


Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 152
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 152
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro 
    210                 215                 220                 


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser 
225                 230                 235                 240 


Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala Pro 
    610                 615                 620                 


His His His His His His 
625                 630 


<210> 153
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 153
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Lys Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro 
        195                 200                 205             


Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro 
    210                 215                 220                 


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser 
225                 230                 235                 240 


Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Leu Gln Tyr Asp Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            260                 265                 270         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
            340                 345                 350         


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
385                 390                 395                 400 


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
545                 550                 555                 560 


Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln 
                565                 570                 575     


Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser 
            580                 585                 590         


Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg 
        595                 600                 605             


Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly Ala 
    610                 615                 620             


<210> 154
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 154
Gly Tyr Ser Phe Thr Asp Tyr Asn 
1               5               


<210> 155
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 155
Ile Asp Pro Tyr Lys Gly Gly Thr 
1               5               


<210> 156
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 156
Ala Arg Glu Met Ile Thr Ala Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 157
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 157
Gln Asp Ile Asn Lys Tyr 
1               5       


<210> 158
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 158
Tyr Ala Ser 
1           


<210> 159
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 159
Leu Gln Tyr Asp Asn Leu Leu Thr 
1               5               


<210> 160
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 160
His His His His His His 
1               5       


<210> 161
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 161
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 162
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 162
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 163
Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   


<210> 164
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 164
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 165
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 165
Gly Gly Gly Gly Ser 
1               5   


<210> 166
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(75) 
<223> This sequence may encompass 1-15 "Gly Gly Gly Gly Ser"
      repeating units

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 166
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75  


<210> 167
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(150) 
<223> This sequence may encompass 1-30 "Gly Gly Gly Gly Ser"
      repeating units

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 167
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 



