                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  Rodents Having Genetically Modified Sodium Channels and Methods of Use Thereof

<130>  36328PCT (10403WO01)

<150>  62/808,957
<151>  2019-02-22


<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  9865
<212>  DNA
<213>  Mus musculus

<400>  1
gcacacaccc cacccagaga ggtggccgcg ggtgagaggc tgtgcgaccc acctcctgtc       60

ccttcttcta gcacggagta tagaggctgc cgcatcccta gcatcaccac gcccaatcgc      120

caggtctccg ccctgcaccg tctaccgggc tgggaggagg gagctagggg tggggacccg      180

agagctcagg gagcatcgag gaggcctagc gacgcggttg gcagccgagg gcggggtcgc      240

ttcatcctga gcagactaga aacagacaga ctccgtgcag gcctagcctg cgctccaatt      300

gcgactctag ccttttcaat cctgcccact gtgcaggctg gtctggtcta gcctgggtat      360

cccggactcc tagtagcagg cactgtgagc aacaggattt caaagaaaga agcagaggga      420

agaaagaagc ctgggaagag aggaagactt cccttggatc agaatccgca ggtgcactca      480

ccgggtgggc atgatccgtg gggccaggcc tcttaggtaa ggatccgaag gggaaataaa      540

acctacagga tgagaagatg gcgatgttgc ctccgccagg acctcagagc ttcgttcact      600

tcacaaaaca gtcccttgcc ctcattgaac aacgcatttc tgaagaaaaa gccaagggac      660

acaaagatga aaagaaagat gatgaggaag aaggtcccaa gcccagtagt gacttggaag      720

caggtaaaca gctacccttc atctacggag acattccccc gggaatggtg tcagagcccc      780

tggaggacct ggacccatac tatgcagaca aaaaaacttt tatagtattg aacaaaggga      840

aagcaatctt ccgtttcaac gccacccctg ctttgtacat gctgtctccc ttcagtcctc      900

tcagaagaat atctattaag attttagtgc actccttatt cagcatgcta atcatgtgca      960

caattctgac aaactgcata ttcatgacca tgagcaaccc tccagattgg accaaaaacg     1020

tagagtacac ttttactggg atatatactt ttgaatcact cataaaaatc cttgcaagag     1080

gcttttgcgt gggcgaattc accttcctcc gtgacccttg gaactggctg gactttgttg     1140

tcattgtttt tgcgtattta acagaatttg taaacctagg caatgtttca gctcttcgaa     1200

ctttcagagt cttgagagct ttgaaaacta tttctgtaat tccaggacta aaaaccatcg     1260

tgggggccct gatccaatca gtgaagaagc tctctgacgt catgatcctc actgtgttct     1320

gtctcagtgt gttcgcacta attggactac aactgtttat gggcaacttg aagcataaat     1380

gtttccggaa ggaccttgag cagaatgaaa cattagaaag catcatgagt actgctgaga     1440

gtgaagaaga attgaaaaga tatttttatt acttggaggg atccaaagat gctcttcttt     1500

gcggtttcag cacagattca gggcagtgtc ctgaagggta cgagtgtgtg acagctggca     1560

gaaacccaga ttatggctac acaagctttg acacgttcgg ctgggccttc ttggccttgt     1620

ttcggctaat gactcaggac tactgggaga acctttatca acagacactg cgtgctgctg     1680

gcaaaaccta catgattttc tttgtcgtgg tgatatttct gggatccttt tacctgataa     1740

acttgatcct ggctgtggta gccatggcgt acgaggaaca gaaccaggcc aacatcgaag     1800

aagctaaaca gaaagagtta gaatttcagc agatgttaga ccgactcaaa aaagagcagg     1860

aagaagccga ggcgatcgct gcagccgctg ctgagtacac gagtttaggg cggagcagga     1920

ttatgggact ctctgagagc tcttcagaaa cctccaggct gagctcaaag agtgccaagg     1980

agagaagaaa ccgaagaaag aaaaaaaaac agaagctgtc cagtggcgag gaaaagggtg     2040

atgatgagaa gctgtccaag tcagggtcag aggaaagcat ccgaaagaaa agcttccatc     2100

tcggcgtgga agggcaccac cgggccaggg aaaagaggct gtccaccccc aaccagtcac     2160

cactcagcat tcgtgggtcc ttgttttctg ccaggcgcag cagcagaaca agtctcttca     2220

gttttaaggg gcgaggaaga gatctgggat ctgaaacgga atttgctgat gatgagcata     2280

gcatttttgg agacaacgag agcagaaggg gttcactatt tgtaccccat agaccccggg     2340

agcggcgcag cagtaacatc agccaggcca gtaggtcccc accagtgctg ccggtgaacg     2400

ggaagatgca cagtgcagtg gactgcaatg gcgtggtgtc gcttgttgat ggaccctcag     2460

ccctcatgct ccccaatgga cagcttcttc cagaggtgat aatagataag gcaacttccg     2520

acgacagcgg cacaactaat cagatgcgta aaaaaaggct ctctagttct tactttttgt     2580

ctgaggacat gctgaatgac ccacatctca ggcaaagggc catgagcaga gcaagcattc     2640

taaccaacac agtagaagaa cttgaagaat ctagacaaaa atgtccacca tggtggtaca     2700

gatttgctca cacattttta atctggaatt gttctccata ttggataaaa ttcaaaaagt     2760

tcatctattt tattgtaatg gatccttttg tagatcttgc aattaccatt tgcatagttt     2820

taaacacctt gtttatggct atggagcacc atccaatgac ggatgaattc aaaaatgtac     2880

ttgcagtcgg gaacctggtc ttcacaggga tcttcgcagc tgaaatggta ctgaagttaa     2940

tagccatgga tccctatgaa tatttccaag tagggtggaa tatttttgac agcctgattg     3000

tgacgttgag tttggtggag cttttcctag cagatgtgga aggattatca gtcctgcggt     3060

cctttagatt gctgcgagtc ttcaagttgg caaaatcctg gcccacactg aatatgctca     3120

ttaagatcat cggcaactcg gtgggcgcac tgggcaacct gaccctggtg ctggccatca     3180

tcgtcttcat ttttgccgtg gtcggcatgc agctgtttgg aaagagctac aaggagtgtg     3240

tttgcaagat caacgagaac tgcaagctcc cacgctggca catgaacgac ttcttccact     3300

ccttcctgat cgtgttccgt gtgctgtgtg gggagtggat agagaccatg tgggactgca     3360

tggaggttgc gggccagacc atgtgcctta ttgtttacat gatggtcatg gtgattggga     3420

accttgtggt cctgaacctg tttctggctt tattactgag ttcctttagt tctgacaatc     3480

ttacagcaat tgaagaagac accgacgcaa acaacctcca gattgcagtg gccagaatta     3540

aaagagggat caattatgtg aaacagaccc tgcgtgaatt cattctaaag tcattttcca     3600

aaaagccaaa gggctccaag gacacaaaac gaacagcgga tcccaacaac aaaagagaaa     3660

actatatctc aaaccgtacc cttgcggaga taagcaaaga tcacaatttc ctcaaagaaa     3720

aggataagat cagtggtttt agcagcagtc tagacaaaag ctttatggat gaaaacgatt     3780

accagtcctt tattcataat cccagcctca cagtgacagt gcccattgca cctggggagt     3840

ctgatttgga gaatatgaac acagaagagc ttagcagtga ctcagatagt gactacagca     3900

aagagagacg gaaccgatca agttcttcag agtgcagcac agttgataac cctctgccag     3960

gagaagagga ggcagaagct gagcctatca atgcagatga gcccgaagcc tgttttacag     4020

atggctgtgt gaggagattt ccatgctgcc aagttaacat agactccggg aaagggaaag     4080

tttggtggac catccggaag acctgctaca ggatagtgga gcacagctgg tttgaaagct     4140

tcattgttct catgatcctg ctcagcagtg gagctctggc ttttgaggat atatatattg     4200

aaaagaaaaa gaccattaag attatcctgg agtatgctga caagatattc acctacatct     4260

tcattctgga aatgcttcta aaatgggtgg catacgggta taaaacatat ttcactaatg     4320

cctggtgttg gctggacttc ttaattgttg atgtgtctct agttacttta gtagccaaca     4380

ctcttggcta ctcagacctt ggccccatta aatctctacg gacactgagg gccctaagac     4440

ccctaagagc tttgtctaga tttgaaggaa tgagggtagt ggtcaacgca ctcataggag     4500

caatcccttc catcatgaat gtgcttcttg tgtgccttat attctggcta atatttagca     4560

tcatgggagt caatctgttt gctggcaagt tctatgagtg tgttaacacc acagatggct     4620

cacgattttc tgtatctcaa gttgcaaacc gttctgagtg ttttgccctg atgaatgtta     4680

gtggaaatgt gcgatggaaa aacctgaaag taaacttcga taacgttgga cttggttacc     4740

tgtcgctgct tcaagttgca acgttcaagg gctggatgga tattatgtat gcagcagttg     4800

actctgttaa tgtaaatgca caaccaatat atgaatacaa cctctacatg tacatttatt     4860

ttgtcatctt catcatcttt ggctcattct tcactttgaa cttgttcatt ggtgtcatca     4920

tcgataattt caaccaacag aagaagaagc ttggaggtca agatatcttt atgacagaag     4980

aacagaagaa atactataat gcaatgaaga agctggggtc caagaaacca caaaaaccaa     5040

ttccgaggcc agggaacaaa ttccaaggat gcatatttga cttagtgaca aaccaagctt     5100

ttgatatcac catcatggtt cttatctgcc tcaatatggt aaccatgatg gtagaaaaag     5160

aggggcaaac tgactacatg agttttgtgc tatactggat caacgtggtc ttcatcatcc     5220

tgttcactgg ggagtgtgtg ctgaagctga tctctctcag gcattactac ttcactgtgg     5280

gatggaacat ttttgatttt gtggtagtga tcctctccat tgtaggaatg tttctcgctg     5340

agatgataga gaagtatttc gtgtctccta ccctgttccg agtcattcgc ctggccagga     5400

ttggacgaat cctacgcctg atcaaaggcg ccaaggggat ccgcacgctg ctctttgctc     5460

tgatgatgtc ccttcctgcg ctgttcaaca tcggcctcct gcttttcctc gtcatgttca     5520

tctacgccat ctttgggatg tccaactttg cctacgttaa aaaggaagct ggaattaatg     5580

acatgttcaa ctttgagacc ttcggcaaca gcatgatctg cctgttccaa atcaccacct     5640

ctgcgggctg ggatggactg ctggccccca tcctcaacag tgcacctcct gactgtgacc     5700

caaaaaaggt tcacccagga agttcagtgg aaggggactg tggaaatcca tctgtgggaa     5760

ttttctactt tgtcagctac atcatcatat ccttcctggt tgtggtgaac atgtacattg     5820

ctgtcatcct ggagaacttc agcgttgcca cagaagaaag tactgagccc ctgagtgagg     5880

acgactttga gatgttctac gaagtctggg agaagttcga ccctgacgcc acccagttca     5940

tagagttctg caagctctct gactttgcag cagccctgga tcctcccctc ctcatcgcaa     6000

agccaaacaa agtccagctc attgccatgg acctgcccat ggtgagtgga gaccgcatcc     6060

actgcctgga catcttattt gcttttacaa agcgggtcct gggcgagagc ggagagatgg     6120

attcccttcg ttcacagatg gaagaaaggt ttatgtcagc caatccttct aaagtgtcct     6180

atgagcccat cacaaccaca ctgaagcgaa aacaagagga tgtatctgcg actatcattc     6240

agcgtgctta cagacggtac cgccttaggc aaaacgtcaa gaatatatca agtatatata     6300

taaaagatgg agacagagat gacgatttgc ccaataaaga agatatagtt tttgataatg     6360

ttaacgagaa ctcaagtcca gaaaagacag atgcaacagc ctctaccatc tctccacctt     6420

cctatgacag tgtcacaaag ccagatcaag agaaatatga aacagacaaa acggagaagg     6480

aagacaaaga gaaagacgaa agcaggaaat agagcttcgg ttttgataca ctgtttacag     6540

cctgcgaagg tgactcactc gtgttaataa gactctttta cggaggtcta tgccaaactc     6600

tttttatcaa atattctcaa aggcagcaca gccactagct ctgatccagt gaaacaagag     6660

agaagcattt acacatggct actttttgcg ttggtcaatg attctttaag aattgtgcat     6720

gtaactctac agggaataat cattattgca atcaagggtg acttaatgat tttaaatatc     6780

agaaaaccac atagaacatt ttctcttttg cctccatttc tttccctaga ttctaagtag     6840

atgtgtaccc atgtgaatat agaaattcag gcgcacatgc tcacagtcac aaacacaaac     6900

aggattagct gtgatttgga attcgatgta aatatttcac ctgtgatttg caatgaaatt     6960

ccttgtaaaa gaaatgcgaa ttagtgatga aggttttgtg aaaacatctt atcattaggg     7020

agtcagaatt tctgtccata aagaattcag tttatatttt gaggtgctga aacttatcct     7080

acattgcatc aaaatcaatt tataggtatc tgtaaaatgt catgggactg aaaaacatat     7140

ataggctact tgtttaagaa atggctttca ttcatataga taggcattca ccttgattta     7200

tggacatctt tggcattttg tgatcacatg attcttccac aaaattgctt agctggaact     7260

tcaggcacac atcacagaga acagctaccc agtcttatgc ccctctctgt ttgtacaata     7320

atcacagagc ttgaaacatt atttgaacta taaatatcag gtttctccac atagacatat     7380

gaatattgtt aacagaaaaa aattttattt acagcgtttt atttactaat atttatccaa     7440

tctagtttgc ccaatgagac agctcatgac tcacatctga aagccagttg ccacatttat     7500

cttcttatgt aactttggtt tgtcatactt tatgtctaag caaattgaat gtctcctttc     7560

taatgagatg taccctgaaa tgcagttagg tacttgatac tttagcgctt gtttgagcag     7620

atgactggag cacagtgtgg actgcatctc ttaaatacaa tccttaatgt gtttggcagc     7680

ttctcaggtt acaaggaaca cccggctttt agtgtctatc tgttcaccag gtgtttagta     7740

tgaatgaaac ggcattcaaa gagtgagtct cactggcttg ctttattact gatgccttcc     7800

ctatggagaa ttaatcctct gaagccccat tatgtccccc tgtaaataat gtagatgtca     7860

cttccttctt aatattctaa tccatactgt gaaatcgatt ttgcatttat cggtcaaata     7920

gagcattttg agatagttgg agttaccctg ccaaggatta gaaatctact tcatgttttt     7980

aaagtacttg ttaaaaatga acgaccctgg cacattctct cataatttta ttccagccat     8040

gtgaaatctt tcttctaaac actttatcct tgcggaggaa aaaaaaaatg agctgatgag     8100

ccatttaagc acaaaggggc tttatttaga agattccaag ggggaacttt gaagtaaata     8160

tataaaacat acttcatcaa tttgcctata aaactaaaag aggaacacag gaatattgat     8220

aaaataagtc attaaaacac attctttatt tcttgcccag tttaaaagaa agaactaaac     8280

atccctagag agaggaagag acatagagag agagtgacta atagaaagag ggagagaaga     8340

aacaaggcac caaggacaaa aagagataat tagacagaac ttgtccaggt tttcacacta     8400

tgtgctctgt ccagtaccgt acacaagaac ctctttccaa atatttgtcc taaggctcta     8460

agaagttaag tacgaggctg aaggttgaat acaactgtct ttaatcatta acagtttggg     8520

gagctacttt taaacgtcta tggaagatgc caagcagtgg taagccagac aatacagagc     8580

actgcatatc tgtcaagcag ctgaaatatg tttgggcaac ttaatggtga gccacacaaa     8640

acatccattt gtaacaattt taatacattc aattaagaaa ccaggatttt tattattttg     8700

cacccataaa aatataacta tattgttcat ttttattgat agagtatgtg tgaatcttat     8760

tgattatctg taatttacta ttaatgtttt tacagtgact gttttttttg tgtgtgtaaa     8820

cttaatatat gtcagcaact ggttcctcaa cacaattttt tttagcatta caaaaaaatg     8880

aacaggtata aaggttctct tttttctaca tcatgttgaa catattttgt tctgaattac     8940

atagttttaa atgtaatatt aagttttata ttcatatatg tttaacatca aaatcactac     9000

ttatgacatt gttatcaatt taaaaaatag tatttgacac taggatagca tttaattaaa     9060

gctaaaaagc ttacacccca tttcatgttg attagtgttt ggactaactc taaaatgtca     9120

tcaatggaag ctagtcactg aaattatttt atctattgtc atagaatggt gactacccaa     9180

aaaatataag ttagcattaa atagaagaaa gcgtacgtga ccacaaatcc atgcacaggg     9240

ttgtgtgaag acaggagaac ctcatttttc tgttttgtct ctttccactg tgtaaaaagt     9300

ctacatctgt gggctatttc taaattcaaa ttgtcacaat ttgcaatcat aaatgtttag     9360

catactttgt agaattttga tagttttgta aaagagtgaa aaacaaatgc atatgtaaat     9420

aaagcagccc atactagcag attcctcaaa tgttaatatg taaataaagc agcccttact     9480

agcagattca tcaaatgtta atatgtaaat aaagcagtcc ttattagcag atttgtcata     9540

tgttaagggg agtaatgata aggaggcaac taaatcagga tggtcagtaa ctgatctggg     9600

tttagaactg tgtttggagc catcaatttt taaatatatg ttctcactat gttattagtt     9660

gtctgaagaa gcaatcaaga attgctccca gaaaatgagt aagtagccat gaatatatga     9720

atgctgttta cagaacccat agacctatga atgctcaaaa tgtttgggtt tgtcaaaaaa     9780

ttacattgta gttatacttg atacttaaaa actgttaata gagtctaaaa taaaagtcgc     9840

taaaattaaa aaaaaaaaaa aaaaa                                           9865


<210>  2
<211>  1984
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ser Glu Glu Lys Ala 
            20                  25                  30          


Lys Gly His Lys Asp Glu Lys Lys Asp Asp Glu Glu Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Lys Asp Leu Glu Gln Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Ser Thr Ala Glu Ser Glu Glu Glu Leu Lys Arg Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Glu Cys Val Thr Ala Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Gly Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Leu Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Arg Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Lys Gln Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asp 
                485                 490                 495     


Glu Lys Leu Ser Lys Ser Gly Ser Glu Glu Ser Ile Arg Lys Lys Ser 
            500                 505                 510         


Phe His Leu Gly Val Glu Gly His His Arg Ala Arg Glu Lys Arg Leu 
        515                 520                 525             


Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
    530                 535                 540                 


Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
545                 550                 555                 560 


Arg Asp Leu Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                565                 570                 575     


Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
            580                 585                 590         


Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
        595                 600                 605             


Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
    610                 615                 620                 


Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
625                 630                 635                 640 


Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                645                 650                 655     


Ser Gly Thr Thr Asn Gln Met Arg Lys Lys Arg Leu Ser Ser Ser Tyr 
            660                 665                 670         


Phe Leu Ser Glu Asp Met Leu Asn Asp Pro His Leu Arg Gln Arg Ala 
        675                 680                 685             


Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
    690                 695                 700                 


Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
705                 710                 715                 720 


Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Phe Ile 
                725                 730                 735     


Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
            740                 745                 750         


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
        755                 760                 765             


Asp Glu Phe Lys Asn Val Leu Ala Val Gly Asn Leu Val Phe Thr Gly 
    770                 775                 780                 


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
785                 790                 795                 800 


Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                805                 810                 815     


Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
        835                 840                 845             


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
    850                 855                 860                 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
865                 870                 875                 880 


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
                885                 890                 895     


Lys Ile Asn Glu Asn Cys Lys Leu Pro Arg Trp His Met Asn Asp Phe 
            900                 905                 910         


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
        915                 920                 925             


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
    930                 935                 940                 


Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
945                 950                 955                 960 


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr 
                965                 970                 975     


Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Ala 
            980                 985                 990         


Arg Ile Lys Arg Gly Ile Asn Tyr  Val Lys Gln Thr Leu  Arg Glu Phe 
        995                 1000                 1005             


Ile Leu  Lys Ser Phe Ser Lys  Lys Pro Lys Gly Ser  Lys Asp Thr 
    1010                 1015                 1020             


Lys Arg  Thr Ala Asp Pro Asn  Asn Lys Arg Glu Asn  Tyr Ile Ser 
    1025                 1030                 1035             


Asn Arg  Thr Leu Ala Glu Ile  Ser Lys Asp His Asn  Phe Leu Lys 
    1040                 1045                 1050             


Glu Lys  Asp Lys Ile Ser Gly  Phe Ser Ser Ser Leu  Asp Lys Ser 
    1055                 1060                 1065             


Phe Met  Asp Glu Asn Asp Tyr  Gln Ser Phe Ile His  Asn Pro Ser 
    1070                 1075                 1080             


Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly Glu Ser  Asp Leu Glu 
    1085                 1090                 1095             


Asn Met  Asn Thr Glu Glu Leu  Ser Ser Asp Ser Asp  Ser Asp Tyr 
    1100                 1105                 1110             


Ser Lys  Glu Arg Arg Asn Arg  Ser Ser Ser Ser Glu  Cys Ser Thr 
    1115                 1120                 1125             


Val Asp  Asn Pro Leu Pro Gly  Glu Glu Glu Ala Glu  Ala Glu Pro 
    1130                 1135                 1140             


Ile Asn  Ala Asp Glu Pro Glu  Ala Cys Phe Thr Asp  Gly Cys Val 
    1145                 1150                 1155             


Arg Arg  Phe Pro Cys Cys Gln  Val Asn Ile Asp Ser  Gly Lys Gly 
    1160                 1165                 1170             


Lys Val  Trp Trp Thr Ile Arg  Lys Thr Cys Tyr Arg  Ile Val Glu 
    1175                 1180                 1185             


His Ser  Trp Phe Glu Ser Phe  Ile Val Leu Met Ile  Leu Leu Ser 
    1190                 1195                 1200             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Ile Glu  Lys Lys Lys 
    1205                 1210                 1215             


Thr Ile  Lys Ile Ile Leu Glu  Tyr Ala Asp Lys Ile  Phe Thr Tyr 
    1220                 1225                 1230             


Ile Phe  Ile Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Tyr 
    1235                 1240                 1245             


Lys Thr  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1250                 1255                 1260             


Val Asp  Val Ser Leu Val Thr  Leu Val Ala Asn Thr  Leu Gly Tyr 
    1265                 1270                 1275             


Ser Asp  Leu Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1280                 1285                 1290             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1295                 1300                 1305             


Val Asn  Ala Leu Ile Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1310                 1315                 1320             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1325                 1330                 1335             


Asn Leu  Phe Ala Gly Lys Phe  Tyr Glu Cys Val Asn  Thr Thr Asp 
    1340                 1345                 1350             


Gly Ser  Arg Phe Ser Val Ser  Gln Val Ala Asn Arg  Ser Glu Cys 
    1355                 1360                 1365             


Phe Ala  Leu Met Asn Val Ser  Gly Asn Val Arg Trp  Lys Asn Leu 
    1370                 1375                 1380             


Lys Val  Asn Phe Asp Asn Val  Gly Leu Gly Tyr Leu  Ser Leu Leu 
    1385                 1390                 1395             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1400                 1405                 1410             


Val Asp  Ser Val Asn Val Asn  Ala Gln Pro Ile Tyr  Glu Tyr Asn 
    1415                 1420                 1425             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1430                 1435                 1440             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1445                 1450                 1455             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1460                 1465                 1470             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1475                 1480                 1485             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Gly Asn  Lys Phe Gln 
    1490                 1495                 1500             


Gly Cys  Ile Phe Asp Leu Val  Thr Asn Gln Ala Phe  Asp Ile Thr 
    1505                 1510                 1515             


Ile Met  Val Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1520                 1525                 1530             


Lys Glu  Gly Gln Thr Asp Tyr  Met Ser Phe Val Leu  Tyr Trp Ile 
    1535                 1540                 1545             


Asn Val  Val Phe Ile Ile Leu  Phe Thr Gly Glu Cys  Val Leu Lys 
    1550                 1555                 1560             


Leu Ile  Ser Leu Arg His Tyr  Tyr Phe Thr Val Gly  Trp Asn Ile 
    1565                 1570                 1575             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Met Phe Leu 
    1580                 1585                 1590             


Ala Glu  Met Ile Glu Lys Tyr  Phe Val Ser Pro Thr  Leu Phe Arg 
    1595                 1600                 1605             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Lys 
    1610                 1615                 1620             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1625                 1630                 1635             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1640                 1645                 1650             


Phe Ile  Tyr Ala Ile Phe Gly  Met Ser Asn Phe Ala  Tyr Val Lys 
    1655                 1660                 1665             


Lys Glu  Ala Gly Ile Asn Asp  Met Phe Asn Phe Glu  Thr Phe Gly 
    1670                 1675                 1680             


Asn Ser  Met Ile Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1685                 1690                 1695             


Asp Gly  Leu Leu Ala Pro Ile  Leu Asn Ser Ala Pro  Pro Asp Cys 
    1700                 1705                 1710             


Asp Pro  Lys Lys Val His Pro  Gly Ser Ser Val Glu  Gly Asp Cys 
    1715                 1720                 1725             


Gly Asn  Pro Ser Val Gly Ile  Phe Tyr Phe Val Ser  Tyr Ile Ile 
    1730                 1735                 1740             


Ile Ser  Phe Leu Val Val Val  Asn Met Tyr Ile Ala  Val Ile Leu 
    1745                 1750                 1755             


Glu Asn  Phe Ser Val Ala Thr  Glu Glu Ser Thr Glu  Pro Leu Ser 
    1760                 1765                 1770             


Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Val Trp Glu  Lys Phe Asp 
    1775                 1780                 1785             


Pro Asp  Ala Thr Gln Phe Ile  Glu Phe Cys Lys Leu  Ser Asp Phe 
    1790                 1795                 1800             


Ala Ala  Ala Leu Asp Pro Pro  Leu Leu Ile Ala Lys  Pro Asn Lys 
    1805                 1810                 1815             


Val Gln  Leu Ile Ala Met Asp  Leu Pro Met Val Ser  Gly Asp Arg 
    1820                 1825                 1830             


Ile His  Cys Leu Asp Ile Leu  Phe Ala Phe Thr Lys  Arg Val Leu 
    1835                 1840                 1845             


Gly Glu  Ser Gly Glu Met Asp  Ser Leu Arg Ser Gln  Met Glu Glu 
    1850                 1855                 1860             


Arg Phe  Met Ser Ala Asn Pro  Ser Lys Val Ser Tyr  Glu Pro Ile 
    1865                 1870                 1875             


Thr Thr  Thr Leu Lys Arg Lys  Gln Glu Asp Val Ser  Ala Thr Ile 
    1880                 1885                 1890             


Ile Gln  Arg Ala Tyr Arg Arg  Tyr Arg Leu Arg Gln  Asn Val Lys 
    1895                 1900                 1905             


Asn Ile  Ser Ser Ile Tyr Ile  Lys Asp Gly Asp Arg  Asp Asp Asp 
    1910                 1915                 1920             


Leu Pro  Asn Lys Glu Asp Ile  Val Phe Asp Asn Val  Asn Glu Asn 
    1925                 1930                 1935             


Ser Ser  Pro Glu Lys Thr Asp  Ala Thr Ala Ser Thr  Ile Ser Pro 
    1940                 1945                 1950             


Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Asp Gln Glu  Lys Tyr Glu 
    1955                 1960                 1965             


Thr Asp  Lys Thr Glu Lys Glu  Asp Lys Glu Lys Asp  Glu Ser Arg 
    1970                 1975                 1980             


Lys 
    


<210>  3
<211>  8876
<212>  DNA
<213>  Homo sapiens

<400>  3
ggctgcttca gacatatgtc tgtgtgtacg ctgtgaaggt gtttctcttc acagttcccc       60

gccctctagt ggtagttaca ataatgccat tttgtagtcc ctgtacagga aatgcctctt      120

cttacttcag ttaccagaat ccttttacag gaagttaggt gtggtctttg aaggagaatt      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaga tttttttttt tttaaagcat gatggaattt      240

tagctgcagt cttcttggtg ccagcttatc aatcccaaac tctgggtgta aaagattcta      300

cagggcactt tcttatgcaa ggagctaaac agtgattaaa ggagcaggat gaaaagatgg      360

cacagtcagt gctggtaccg ccaggacctg acagcttccg cttctttacc agggaatccc      420

ttgctgctat tgaacaacgc attgcagaag agaaagctaa gagacccaaa caggaacgca      480

aggatgagga tgatgaaaat ggcccaaagc caaacagtga cttggaagca ggaaaatctc      540

ttccatttat ttatggagac attcctccag agatggtgtc agtgcccctg gaggatctgg      600

acccctacta tatcaataag aaaacgttta tagtattgaa taaagggaaa gcaatctctc      660

gattcagtgc cacccctgcc ctttacattt taactccctt caaccctatt agaaaattag      720

ctattaagat tttggtacat tctttattca atatgctcat tatgtgcacg attcttacca      780

actgtgtatt tatgaccatg agtaaccctc cagactggac aaagaatgtg gagtatacct      840

ttacaggaat ttatactttt gaatcactta ttaaaatact tgcaaggggc ttttgtttag      900

aagatttcac atttttacgg gatccatgga attggttgga tttcacagtc attacttttg      960

catatgtgac agagtttgtg gacctgggca atgtctcagc gttgagaaca ttcagagttc     1020

tccgagcatt gaaaacaatt tcagtcattc caggcctgaa gaccattgtg ggggccctga     1080

tccagtcagt gaagaagctt tctgatgtca tgatcttgac tgtgttctgt ctaagcgtgt     1140

ttgcgctaat aggattgcag ttgttcatgg gcaacctacg aaataaatgt ttgcaatggc     1200

ctccagataa ttcttccttt gaaataaata tcacttcctt ctttaacaat tcattggatg     1260

ggaatggtac tactttcaat aggacagtga gcatatttaa ctgggatgaa tatattgagg     1320

ataaaagtca cttttatttt ttagaggggc aaaatgatgc tctgctttgt ggcaacagct     1380

cagatgcagg ccagtgtcct gaaggataca tctgtgtgaa ggctggtaga aaccccaact     1440

atggctacac gagctttgac acctttagtt gggccttttt gtccttattt cgtctcatga     1500

ctcaagactt ctgggaaaac ctttatcaac tgacactacg tgctgctggg aaaacgtaca     1560

tgatattttt tgtgctggtc attttcttgg gctcattcta tctaataaat ttgatcttgg     1620

ctgtggtggc catggcctat gaggaacaga atcaggccac attggaagag gctgaacaga     1680

aggaagctga atttcagcag atgctcgaac agttgaaaaa gcaacaagaa gaagctcagg     1740

cggcagctgc agccgcatct gctgaatcaa gagacttcag tggtgctggt gggataggag     1800

ttttttcaga gagttcttca gtagcatcta agttgagctc caaaagtgaa aaagagctga     1860

aaaacagaag aaagaaaaag aaacagaaag aacagtctgg agaagaagag aaaaatgaca     1920

gagtccgaaa atcggaatct gaagacagca taagaagaaa aggtttccgt ttttccttgg     1980

aaggaagtag gctgacatat gaaaagagat tttcttctcc acaccagtcc ttactgagca     2040

tccgtggctc ccttttctct ccaagacgca acagtagggc gagccttttc agcttcagag     2100

gtcgagcaaa ggacattggc tctgagaatg actttgctga tgatgagcac agcacctttg     2160

aggacaatga cagccgaaga gactctctgt tcgtgccgca cagacatgga gaacggcgcc     2220

acagcaatgt cagccaggcc agccgtgcct ccagggtgct ccccatcctg cccatgaatg     2280

ggaagatgca tagcgctgtg gactgcaatg gtgtggtctc cctggtcggg ggcccttcta     2340

ccctcacatc tgctgggcag ctcctaccag agggcacaac tactgaaaca gaaataagaa     2400

agagacggtc cagttcttat catgtttcca tggatttatt ggaagatcct acatcaaggc     2460

aaagagcaat gagtatagcc agtattttga ccaacaccat ggaagaactt gaagaatcca     2520

gacagaaatg cccaccatgc tggtataaat ttgctaatat gtgtttgatt tgggactgtt     2580

gtaaaccatg gttaaaggtg aaacaccttg tcaacctggt tgtaatggac ccatttgttg     2640

acctggccat caccatctgc attgtcttaa atacactctt catggctatg gagcactatc     2700

ccatgacgga gcagttcagc agtgtactgt ctgttggaaa cctggtcttc acagggatct     2760

tcacagcaga aatgtttctc aagataattg ccatggatcc atattattac tttcaagaag     2820

gctggaatat ttttgatggt tttattgtga gccttagttt aatggaactt ggtttggcaa     2880

atgtggaagg attgtcagtt ctccgatcat tccggctgct ccgagttttc aagttggcaa     2940

aatcttggcc aactctaaat atgctaatta agatcattgg caattctgtg ggggctctag     3000

gaaacctcac cttggtattg gccatcatcg tcttcatttt tgctgtggtc ggcatgcagc     3060

tctttggtaa gagctacaaa gaatgtgtct gcaagatttc caatgattgt gaactcccac     3120

gctggcacat gcatgacttt ttccactcct tcctgatcgt gttccgcgtg ctgtgtggag     3180

agtggataga gaccatgtgg gactgtatgg aggtcgctgg ccaaaccatg tgccttactg     3240

tcttcatgat ggtcatggtg attggaaatc tagtggttct gaacctcttc ttggccttgc     3300

ttttgagttc cttcagttct gacaatcttg ctgccactga tgatgataac gaaatgaata     3360

atctccagat tgctgtggga aggatgcaga aaggaatcga ttttgttaaa agaaaaatac     3420

gtgaatttat tcagaaagcc tttgttagga agcagaaagc tttagatgaa attaaaccgc     3480

ttgaagatct aaataataaa aaagacagct gtatttccaa ccataccacc atagaaatag     3540

gcaaagacct caattatctc aaagacggaa atggaactac tagtggcata ggcagcagtg     3600

tagaaaaata tgtcgtggat gaaagtgatt acatgtcatt tataaacaac cctagcctca     3660

ctgtgacagt accaattgct gttggagaat ctgactttga aaatttaaat actgaagaat     3720

tcagcagcga gtcagatatg gaggaaagca aagagaagct aaatgcaact agttcatctg     3780

aaggcagcac ggttgatatt ggagctcccg ccgagggaga acagcctgag gttgaacctg     3840

aggaatccct tgaacctgaa gcctgtttta cagaagactg tgtacggaag ttcaagtgtt     3900

gtcagataag catagaagaa ggcaaaggga aactctggtg gaatttgagg aaaacatgct     3960

ataagatagt ggagcacaat tggttcgaaa ccttcattgt cttcatgatt ctgctgagca     4020

gtggggctct ggcctttgaa gatatataca ttgagcagcg aaaaaccatt aagaccatgt     4080

tagaatatgc tgacaaggtt ttcacttaca tattcattct ggaaatgctg ctaaagtggg     4140

ttgcatatgg ttttcaagtg tattttacca atgcctggtg ctggctagac ttcctgattg     4200

ttgatgtctc actggttagc ttaactgcaa atgccttggg ttactcagaa cttggtgcca     4260

tcaaatccct cagaacacta agagctctga ggccactgag agctttgtcc cggtttgaag     4320

gaatgagggt tgttgtaaat gctcttttag gagccattcc atctatcatg aatgtacttc     4380

tggtttgtct gatcttttgg ctaatattca gtatcatggg agtgaatctc tttgctggca     4440

agttttacca ttgtattaat tacaccactg gagagatgtt tgatgtaagc gtggtcaaca     4500

actacagtga gtgcaaagct ctcattgaga gcaatcaaac tgccaggtgg aaaaatgtga     4560

aagtaaactt tgataacgta ggacttggat atctgtctct acttcaagta gccacgttta     4620

agggatggat ggatattatg tatgcagctg ttgattcacg aaatgtagaa ttacaaccca     4680

agtatgaaga caacctgtac atgtatcttt attttgtcat ctttattatt tttggttcat     4740

tctttacctt gaatcttttc attggtgtca tcatagataa cttcaaccaa cagaaaaaga     4800

agtttggagg tcaagacatt tttatgacag aagaacagaa gaaatactac aatgcaatga     4860

aaaaactggg ttcaaagaaa ccacaaaaac ccatacctcg acctgctaac aaattccaag     4920

gaatggtctt tgattttgta accaaacaag tctttgatat cagcatcatg atcctcatct     4980

gccttaacat ggtcaccatg atggtggaaa ccgatgacca gagtcaagaa atgacaaaca     5040

ttctgtactg gattaatctg gtgtttattg ttctgttcac tggagaatgt gtgctgaaac     5100

tgatctctct tcgttactac tatttcacta ttggatggaa tatttttgat tttgtggtgg     5160

tcattctctc cattgtagga atgtttctgg ctgaactgat agaaaagtat tttgtgtccc     5220

ctaccctgtt ccgagtgatc cgtcttgcca ggattggccg aatcctacgt ctgatcaaag     5280

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta     5340

acatcggcct ccttcttttc ctggtcatgt tcatctacgc catctttggg atgtccaatt     5400

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca     5460

acagcatgat ctgcctgttc caaattacaa cctctgctgg ctgggatgga ttgctagcac     5520

ctattcttaa tagtggacct ccagactgtg accctgacaa agatcaccct ggaagctcag     5580

ttaaaggaga ctgtgggaac ccatctgttg ggattttctt ttttgtcagt tacatcatca     5640

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg     5700

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt     5760

gggagaagtt tgatcccgat gcgacccagt ttatagagtt tgccaaactt tctgattttg     5820

cagatgccct ggatcctcct cttctcatag caaaacccaa caaagtccag ctcattgcca     5880

tggatctgcc catggtgagt ggtgaccgga tccactgtct tgacatctta tttgctttta     5940

caaagcgtgt tttgggtgag agtggagaga tggatgccct tcgaatacag atggaagagc     6000

gattcatggc atcaaacccc tccaaagtct cttatgagcc cattacgacc acgttgaaac     6060

gcaaacaaga ggaggtgtct gctattatta tccagagggc ttacagacgc tacctcttga     6120

agcaaaaagt taaaaaggta tcaagtatat acaagaaaga caaaggcaaa gaatgtgatg     6180

gaacacccat caaagaagat actctcattg ataaactgaa tgagaattca actccagaga     6240

aaaccgatat gacgccttcc accacgtctc caccctcgta tgatagtgtg accaaaccag     6300

aaaaagaaaa atttgaaaaa gacaaatcag aaaaggaaga caaagggaaa gatatcaggg     6360

aaagtaaaaa gtaaaaagaa accaagaatt ttccattttg tgatcaattg tttacagccc     6420

gtgatggtga tgtgtttgtg tcaacaggac tcccacagga ggtctatgcc aaactgactg     6480

tttttacaaa tgtatactta aggtcagtgc ctataacaag acagagacct ctggtcagca     6540

aactggaact cagtaaactg gagaaatagt atcgatggga ggtttctatt ttcacaacca     6600

gctgacactg ctgaagagca gaggcgtaat ggctactcag acgataggaa ccaatttaaa     6660

ggggggaggg aagttaaatt tttatgtaaa ttcaacatgt gacacttgat aatagtaatt     6720

gtcaccagtg tttatgtttt aactgccaca cctgccatat ttttacaaaa cgtgtgctgt     6780

gaatttatca cttttctttt taattcacag gttgtttact attatatgtg actatttttg     6840

taaatgggtt tgtgtttggg gagagggatt aaagggaggg aattctacat ttctctattg     6900

tattgtataa ctggatatat tttaaatgga ggcatgctgc aattctcatt cacacataaa     6960

aaaatcacat cacaaaaggg aagagtttac ttcttgtttc aggatgtttt tagatttttg     7020

aggtgcttaa atagctattc gtatttttaa ggtgtctcat ccagaaaaaa tttaatgtgc     7080

ctgtaaatgt tccatagaat cacaagcatt aaagagttgt tttattttta cataacccat     7140

taaatgtaca tgtatatatg tatatatgta tatgtgcgtg tatatacata tatatgtata     7200

cacacatgca cacacagaga tatacacata ccattacatt gtcattcaca gtcccagcag     7260

catgactatc acatttttga taagtgtcct ttggcataaa ataaaaatat cctatcagtc     7320

ctttctaaga agcctgaatt gaccaaaaaa catccccacc accactttat aaagttgatt     7380

ctgctttatc ctgcagtatt gtttagccat cttctgctct tggtaaggtt gacatagtat     7440

atgtcaattt aaaaaataaa agtctgcttt gtaaatagta attttaccca gtggtgcatg     7500

tttgagcaaa caaaaatgat gatttaagca cactacttat tgcatcaaat atgtaccaca     7560

gtaagtatag tttgcaagct ttcaacaggt aatatgatgt aattggttcc attatagttt     7620

gaagctgtca ctgctgcatg tttatcttgc ctatgctgct gtatcttatt ccttccactg     7680

ttcagaagtc taatatggga agccatatat cagtggtaaa gtgaagcaaa ttgttctacc     7740

aagacctcat tcttcatgtc attaagcaat aggttgcagc aaacaaggaa gagcttcttg     7800

ctttttattc ttccaacctt aattgaacac tcaatgatga aaagcccgac tgtacaaaca     7860

tgttgcaagc tgcttaaatc tgtttaaaat atatggttag agttttctaa gaaaatataa     7920

atactgtaaa aagttcattt tattttattt ttcagccttt tgtacgtaaa atgagaaatt     7980

aaaagtatct tcaggtggat gtcacagtca ctattgttag tttctgttcc tagcactttt     8040

aaattgaagc acttcacaaa ataagaagca aggactagga tgcagtgtag gtttctgctt     8100

ttttattagt actgtaaact tgcacacatt tcaatgtgaa acaaatctca aactgagttc     8160

aatgtttatt tgctttcaat agtaatgcct tatcattgaa agaggcttaa agaaaaaaaa     8220

aatcagctga tactcttggc attgcttgaa tccaatgttt ccacctagtc tttttattca     8280

gtaatcatca gtcttttcca atgtttgttt acacagatag atcttattga cccatatggc     8340

actagaactg tatcagatat aatatgggat cccagctttt tttcctctcc cacaaaacca     8400

ggtagtgaag ttatattacc agttacagca aaatactttg tgtttcacaa gcaacaataa     8460

atgtagattc tttatactga agctattgac ttgtagtgtg ttggtgaaat gcatgcagga     8520

aaatgctgtt accataaaga acggtaaacc acattacaat caagccaaaa gaataaaggt     8580

ttcgcttttg tttttgtatt taattgttgt ctttgtttct atctttgaaa tgccatttaa     8640

aggtagattt ctatcatgta aaaataatct atctgaaaaa caaatgtaaa gaacacacat     8700

taattactat aattcatctt tcaatttttt catggaatgg aagttaatta agaagagtgt     8760

attggataac tactttaata ttggccaaaa agctagatat ggcatcaggt agactagtgg     8820

aaagttacaa aaattaataa aaaattgact aacattttaa aaaaaaaaaa aaaaaa         8876


<210>  4
<211>  2005
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Asp Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  5
tctgggcagc tacttgtgg                                                    19


<210>  6
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  6
aatacgttga gcacagaggt cagaagga                                          28


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  7
gttgctctgc tttcttgaac ctc                                               23


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  8
atgtcagcca atccttctaa agtg                                              24


<210>  9
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  9
tcctatgagc ccatcacaac cacac                                             25


<210>  10
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  10
tcctatgagc ccatcacaac cacac                                             25


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  11
gaccgtgtaa tggaccaatg atc                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  12
gaccgtgtaa tggaccaatg atc                                               23


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  13
caccagttct ctgcctgtct c                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  14
tcaggtggat gtcacagtca                                                   20


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  15
tctgttccta gcacttttaa attgaagcac                                        30


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  16
tgcatcctag tccttgcttc tta                                               23


<210>  17
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  17
tcttaggtaa ggatccgaag gggaaataaa acctacagga tgagaagcgt cgacgatggc       60

acagtcagtg ctggtaccgc caggacctga cagcttccgc                            100


<210>  18
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  18
cagcctatag atcacttaga tttagatccc taaaatttgc tgtcactctg taaagtgcac       60

ctcgagataa cttcgtataa tgtatgctat acgaagttat atgcatgcca gtagcagcac      120

ccacgtccac cttctgtcta gtaatgtcca                                       150


<210>  19
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  19
catacacttc attctcagta ttgttttgcc aagttctaat tccatcagac ctcgacctgc       60

agcccctaga taacttcgta taatgtatgc tatacgaagt tatgctagta actataacgg      120

tcctaaggta gcgagctagc agcttcggtt ttgatacact gtttacagcc tgcgaaggtg      180

actcactcgt gttaataaga                                                  200


<210>  20
<211>  101673
<212>  DNA
<213>  Homo sapiens

<400>  20
gcctcttagg taaggatccg aaggggaaat aaaacctaca ggatgagaag cgtcgacgat       60

ggcacagtca gtgctggtac cgccaggacc tgacagcttc cgcttcttta ccagggaatc      120

ccttgctgct attgaacaac gcattgcaga agagaaagct aagagaccca aacaggaacg      180

caaggatgag gatgatgaaa atggcccaaa gccaaacagt gacttggaag caggaaaatc      240

tcttccattt atttatggag acattcctcc agagatggtg tcagtgcccc tggaggatct      300

ggacccctac tatatcaata agaaagtgag ttcttagtca agttgccttc actgcctatt      360

tactaattgg ttctgggcta gtcccaggga tgatggtgaa gaaggctggc ctccttccct      420

ctgtctaaag tatcactaag atgctggatg ggcctgaccg tgtaatggac caatgatcct      480

agaagtcttt tggaagcact catttgaacc tgcatttgtg agacaggcag agaactggtg      540

aggcatcctc cagcgcggga attaaggaag gacaaaagcc tattcacctt cttgaataca      600

aattatatgc ttaaaccagt gtaaattgac cctgattccc taataatgtt gagaagcaaa      660

aactgtaaac taggagtcta tttaaatttt attttttata tttgcaggag tagtatctaa      720

attcctcttt atagtctcta gctctccata agtcactttg atcttcagtg ggtttaatta      780

ttcctttata ccatactttc tcctttctat tgctctccac agaaggaata atagcaggtg      840

acttgtaggt gccaaataag attctgagca aagaacacac ctggaaaacc ttgaagttct      900

catgagaaaa ttttctaacc aaaaaaaaaa atcaaagcct caattttgtg ctttatgtga      960

attataaatg cggttttaaa atacttacat taaaacttga taaagttgct aagaattcct     1020

atggcattga tcacaaattt tcttaataat cctcatgtca tttatcaaat ttaggaaagt     1080

ttatagtgct cagaaaaaaa aagcatctat cttcatgtca tatgatggta attattatgt     1140

tatacactat tttacagggc aatatttata aataatggtt ttacttttct cttaaaatat     1200

tcttaatata tattctaagt tttattttat gtgttgtgtt ttctttttca gacgtttata     1260

gtattgaata aagggaaagc aatctctcga ttcagtgcca cccctgccct ttacatttta     1320

actcccttca accctattag aaaattagct attaagattt tggtacattc atatcctttt     1380

tcaaatcgtc acttaatatg attttcttct ttgaccaagt tattgagcta cacattttcc     1440

aaaatatctg tggttggcaa tgttatgtgt tctttctttt tctttccttt tactcaatcg     1500

ttagcatgtt gcaaaatgag atcacaggta agtgaattac tttcccccgt cttctaagtg     1560

tttcttctct acccaactca ctattacttc tttcttctct tttcttctcc cttacgaatt     1620

gcttgccaca tcccaagcct ttctcattaa ttttgaccat gttaccaggc tttcctcctg     1680

taagtcttca atttacaatg ttaggtaagg gagtaaactc catgagctaa ttttctttac     1740

tgcttttaca tttggaaaat aaatatacat aatctgaatt acaattttgt atgtttttgg     1800

tctgaatttt atgactttct tctattttag catttaaaag ctttgagtta gtaagcgttt     1860

acaattgtgt ctgtaggtat aacacccttt caaatacttt tccaaatttg tttcgcaaca     1920

gccttcttat tgatcttttg ctttctattc ttttcctttc tttttctttt tatcacttgt     1980

tcctatgttt tattgaagtc acaagtcttg ctacaattat ccctctccaa aggattaatg     2040

tctatctatc catatacatt ctcattttat tttttatact ccttattgaa gcacctgctt     2100

tccaaaaatg agattgatga catcttggtg ggagatggca atttgattga ttccttgaaa     2160

ttaaatagag tagttggaaa tgagagattt tattctaggc cagaaacaag tcttgttgac     2220

agccagtctt gggaatgcca atgaagcaaa ggcttggaag actgaagctg tgtggggcag     2280

gggcatttac acgaagaaca cagaagtcat gggaggagga gtgatatgct tcaggaatca     2340

gaggtaaggc aggggaactg aaattaagca aatcctcaga ttaggacagc atgttatttc     2400

ttcttcagaa agaatcgttg cttggaattc catgatgtgg ttagcccagg gcctggtatt     2460

aaggctttca gtataaatat tctccacctt tagcaggcct agaaaatatt tgaattagat     2520

aaggtatgga actaaattaa gtagggaatt caggaaatgg gataagcctg gtacagggta     2580

cttatgtcat ttctgggtgg aggggatgta aagcatgtcc ctagacttgc ctcccagtat     2640

ggcaaatgtt gtctttagaa gtgtaacatt ctgtaaagtc tccttttaac ctctaggttg     2700

ttcctcttcc ccagtttagg tggatatcaa catcttttat ttgatgttta tgtttcatgt     2760

tttaagattt cctagtttct tggcattacc ttaagcaata atgttttctt acctctctct     2820

gttttccaaa taagagaacc cagtagcatg tggggaaaaa gatgtctttg agttagcatt     2880

agaaataaat aataaagttg gaatttatat ttgggtctca tgattataaa ttatgatcta     2940

ttattatgtt tcaagcattt gtaatctgtg cagtgaataa atctctgcat aaactattca     3000

ttatatttta aaataattgt atgttcctta tgcaaacgta atttatatat aaaattacgt     3060

ggaaaattct agcctagaac tagacttctg ttcctagtag acattgggaa aatattcatt     3120

aaataaataa gtgactagta agtcagagat tagagaatca gatacaaaaa aagtgaaaaa     3180

ataagtttga atggatcaga aaaaatcttt cttgtcgtgc atctgaatga tgagatggag     3240

ttaagaaaac ccaatatatt tgttttttac aaaagcagat ttttgtttta aaacttttgt     3300

aatagaccat ggaaaatctc atgaaaacta ttgtccccac ttgaaaaaaa aaatcctagg     3360

agattatgaa tccccattta aaactccctg gaaaagagac tcctggtggt agagggtaag     3420

ggcagtttaa gaaattctga tcagagaata tgagtactaa ggacacagtt tgtgccagga     3480

cctctctaga tatccagata caacttgaat ctgtgggctt gtatttgctt cctgggggaa     3540

agaactcacc ctccacaggc tgaagtcatt gggaggcctg aggagatgca ggttgaaatg     3600

tgaagccagc caggcaaatc tattaaggta tgccaagttg agctgttgat tctctgagaa     3660

gtttacagat ggcttagagt cacaaattta ttccaatgta gaaaattaga ttttaaaaag     3720

tctctaattt cctgacttaa agtgttatat ttcagatgtc tcaccttgga gcagagatat     3780

aacaaaaggc agtgaggcta atagtctaag atacatgaat ccttccatgt tttggtgatg     3840

ctggtgcaat tgatcaaata gcccagtaaa gttagaggta tatagatgct gtagttagta     3900

actgattttc acaataattt tgtcctttat tcctcttgtt gcaaacccta gacttaaatc     3960

ctgattttct gacttcaagt acagtgtctt ttactgtaag ttaaaaatgc ttggagagat     4020

ggtcatggtt gtttggccac agttgggagg tcattgtata tttattacca ctagtttata     4080

aaccaacaag gagccattca tgttaaataa gtttttattt taaacttgga ctaatacctc     4140

tatttcaaac aaaaaccttg acttgtttct caaagagctg ttatctatta ggagctattg     4200

tgtatcaaat tagctttttt aaaaatttat tttggctgaa tgagaaatta tgcttgtgat     4260

atttttacca gggtgcattc tgaaaactga aaattctttt gatgtgccta gtgtcttatt     4320

tgatatttaa ataaaacatg atttattttc tagataacaa acaagttaaa aataatctat     4380

gttcctaaag ttccctacca agcttttaaa tgtgtttcct gtcagctttt attattttaa     4440

gttaatatat gcacactcct ctaatttatt ttgcatttgt tactcatttg ttcatttgca     4500

agtacttact gagtatctac catgtggtag atattcttgt aagcattggg atgcaacatt     4560

gaacaaagtg aagttcctac tctcatgtag ttacattcat gtgagtgtgt gtgtgtgttt     4620

ggaagaagaa agacaataaa caaatacgtc gattgggagc tagtgataag tgttactaag     4680

aaatataaat tagtgtcaaa gggaggagtg acaaggtgtt gttttagatt gtatggccag     4740

taaaatcctt tctgaaaagg taccagttga gcagagatcc gaaggaagca aaagagtgag     4800

atatgggaat ctagggataa agtcagttca aggagaacag caagtatgaa ggtaaagtct     4860

gaaggtggtg gtgcaactag tatgtttaac aatcagcaag gagacctgag tggctggagc     4920

agagtgggaa aggcaggaag cgagaggatg acatcagtgg gagtgaaggt caggggctaa     4980

agttgtaggc gaggtgcagt gggtcattgt gaggacacca catttactct gaatgagact     5040

ccaggagggt tttcagtagc aggatatcat gacttgactc acatatttaa aagatcactc     5100

tggctgcttc atggagaata gactgcataa ggggaaagag tggaagcaag gagactggga     5160

ccgattgtca ttatgaaggc aagagagcat ggtggcttgg agtatggtgg aaacaatgag     5220

gatggtaaaa tgtcatcaaa ttttgaggta ttttgcagaa gagctgacag gatttgctga     5280

gcaattggtt gtggtgtata ggaggaaggc agggactaag gatgattcca agcatttagt     5340

ctggtcaaga aagaaaaatg gagttgtgtt gactgagctt ggggcaactt gagcaaacca     5400

atttggtggg taagatcaag atcttggttt tgaacatgtt atgtttgaga cacctattag     5460

acatcattgg aggagttgag gagttaggtg gctgtgcaaa tctggagttc agaaaagggc     5520

tgggctggag gtgttcaact ttgggagctg tcagtgtaca gctggtattt aaagtcatga     5580

cattggacta ggctgccaaa gagctgagac cctccctcca aatcacacta gtaatgctga     5640

actacctatc atttgaaaat ggtaggaaaa tggaaaacat aggttttggt atcagaaaac     5700

gtagattcaa accctatctc taaaatttac tttttagcta tatgatctta gtccaagtta     5760

ctccaattct ttcgaatctc agtttctcta tctgtaaaat tataatcaca gcttagacat     5820

taataatgat aaaatgtatg acaagtatct agcaccagat cccatgctag tacttagtag     5880

gtactcaata aaggatatct atgacagtaa tagctaaaat tctagcagca actgctgtaa     5940

gattagcaaa aaggaaactc tcatattcct taaggaattg cacaaagaac tttatagaaa     6000

tccctactct gactctgcaa acaaaatctt tatatagcac cagagtttag acctgcaact     6060

gacccaaaca atgtggtcag ttctgtctca ttttgtagat gagttcactg aaacccagag     6120

atatttagtt ttttctaagg ctacattttc tatcagtggc agagctaaaa cttcagacca     6180

ggttttttga ttcttggctc tttgcatttt gcatccaata gaaaacaaat gatttttaaa     6240

ccctcggatt taatatactt ggggcattgc cagtgttctt gttttatgca tttcaaaggt     6300

gcttcttagt tgctccaact tactgattca ttaaatagtg tccatactga gatataaaat     6360

atcatggttt tccatgaaaa gaaatataca ggtttatatg aaagcagatg acacaacaat     6420

ttctctttct tttgttttca atgctcatat gttatcattt agttatctac tggcaaatag     6480

gagtttgttc atattaaaat taaacaatcc aatatttaac actgtatatg tgacatttac     6540

tcgatttttc tgctggctca gaaatatgca ctggtatgca gaaaaagacc tattctattc     6600

tacttcaaat tatccatttt tacattagaa aacctctaac atcaggctat cttctacttc     6660

tagtttatat ataggttaaa aactcctctg caacttctct ggatattata cattattaca     6720

aagtctctga acagagcata atgtcttttc cttcctatag aataacaaag aaatgtccta     6780

taattttata ctctataaat gagttattaa tggtaagaaa ccaataatta ttatcttagt     6840

ggataatgac tgtatactgt aagaaaagta ttatccacat ttatataaga aaactgagcc     6900

tcaaagaatt aaacaaattg ctgaagccca catggctggt aagggatgta tctgaccatg     6960

gttcattgct ctaaatctca tggtgcttca tcctcgctcc acggagacag gggtgggtgt     7020

gccagtgtta tgatgatcca ggctccatgt caagggctac ttaaacaatt ttcactaaaa     7080

acttgaagaa gtgtttcttc ataatataca caaaggaaat attttacatt tgccaactcg     7140

caggttagta tcaatcaaca ggtttaccca ctgttatgta tacctggcat aaagaaatta     7200

atagattaaa aaacatcttt gtcccctgat attataaaag gtttatctgc ctctatttta     7260

ttttacattg aaaagttctt aaagcaatat tgttccagga tacagtgttc ttttgaaaaa     7320

tgtactctat gacttggatt acacatttaa aaaataatat aggatgtatg cattttgcta     7380

ctagtttgag ccttttgaaa tctgctttga cgtggggttt ctatactttt ttgatgcatg     7440

gcatcaccaa tgcaaaatcc atacctacat taaatacttt tgtatttgag tttttgttat     7500

ttgagttttt tttttttttt ttttttttga gacgggttct cgctctgtcg ccctggctgg     7560

agtgcagcag cgcaatctcg gctcactgca agctccgcct tccgggttca cgccattctc     7620

ctgcctcagc ctccggagta gctgggacta caggcgcccg ccaccacgcc cggctgattt     7680

tttgtaattt tagtagagac ggtatttcac cgtgttagcc agggtggtct cgatctcctg     7740

acctcgtgat ccgcccgcct cggcctccca aagtgctggg attacaggcg tgagccaccg     7800

cgcctggcca tatttgagta tttttaagat catctgaaac tatttcagtc actcaccaga     7860

atccaggaat ttgtaaagta tgtgactgat gaaataaatt aacaatgatt tagaaactta     7920

gtgaatttta agcctttcta tttagagata cctatcaaac cacaagcgta aaaacttgac     7980

cctagttatc tactattttt ctattaaaag caaaattgtt ctttttatgt atcagaagtt     8040

ttaacttaag tgtatacttt tattaaaatg atagccatga aataaggaaa atgcctgttt     8100

tcgacttatt atcagtgact aattagaaaa taattatttc tcttgttaat gttgaaatat     8160

atattttact tttttatata taactaaatt ataccactat aaagagtaag tttttaagtg     8220

tcataaaacc attgccgagt ccataatgca gcataattgc ataaggctgt taatttccac     8280

cttatatttt tcttatattt ttaccctcaa aaaatgtaga aacttgtgta aacaatatgt     8340

atatatattt tagacagagt ctcactctgt cacccaggct ggagtgcaat ggcgtgatct     8400

tggctcactg ctacctctgc ctcctgggtt caagtgattc ccctgcctta gcctcctgat     8460

tagctgggat tacaggcatc cgtcacgcct ggctaatttt tgtattttta gtagagacag     8520

agtttcacca ttttacccgg gctggtctca aactcctaac ctcaagtgat ctgcctgcct     8580

cagcctcctg aaatgctgag attataggcg agagccatgg cacctggcca acaatatatt     8640

tgaagacaaa ctttatgctg tatttttaaa taatttatca gaaattgttt ttaaaaactc     8700

catttagtaa caaatgaatt gcaaaattaa tttcattagt caactgacac tgtgaaatag     8760

caaggctata atggtgaata atatagacat gattcctgtc ctcatgacgc tcagagagta     8820

gttgagaaga tcatcattaa aatttgtcat tagaggaata atataagggc tgctggggta     8880

tataactggt aataggtcaa tctgagtact aaagaaaaag agaggtgaca tttccaagac     8940

cctaaagtca gaaacagcat ataaaacatt cataacattt gacaacctaa aataattaca     9000

gtattatcca aatggggata atgcaatgaa gagaaaagaa aatgaaactg gagaagtaga     9060

cagggatcag acctcctagc gtcttgactc tgtgttaaga catttgatca tcatcctaag     9120

agtaatagaa agctaccaaa atgatgcata ttacatttac aatggtcgtg ttagcacagt     9180

atgcagaatg gattaaatgg agccaaacat gaatttggaa acatcagttt agaggagact     9240

gcaataatct agatggacta ttagatttga tgctagtctt gacagacact tggaccatgc     9300

agtgatatgg ggatggaaaa aagtaactga atccagagat agcaggcaga attgacaata     9360

tttgatggtt aattagatat gaacgtttaa ggggagacag aaatctaaga tttctcatag     9420

gtctctggct atattatgca cattttataa gacacagaga cgtcaaagga gtaagtaatt     9480

agcaggaatg gaggggtaga ttaaaagata cttttcaaaa gttcagtttt agaattcaaa     9540

atttgaagtg ttgataagat atgtaagtac agatgtccta tggacaatca agtatgtgga     9600

attcagaaga gcggtctcac ttggagagaa gtatctgaga atggtgggta tataatggtt     9660

atgtttgttg agcaatgttt gttgatggac tacactagga tgaggagagt agaagagagg     9720

tagatggctt acatacctta tgtctttctt ttcaaaaaga aaaatgccac atttcaaaga     9780

atacagagaa attggtgccc tgaggcatga agaagccagg gaattggaac ctcctgaaag     9840

cagagggaag ataacttaat gctaagggga ggaaccatcc ttgttgaatg ctgcttagaa     9900

agcatgtcaa atataatctc aaattatcct tttgttttta gtgacaaaac gtgaagatgt     9960

tgccatcttt agaaagaaaa gctggtaggc tgaatatatg atagatatat aagaaaagga    10020

aagataagca gctctttcaa aaagtttggc catgatatgg aaaagggaga taaggctgta    10080

gtagttaagg agggttgtga gtcataggag agaaatatcc tttcccctat gccaggacaa    10140

gggagacgta agcaagtttg tgttgctggg aaaaagccag taaggtggga gccattaagg    10200

ataagaaaag agagagataa gagattgctg aagtcttctg gaatggggaa ggtgtccaga    10260

ataccggtgg agggattgga aacctcccca ctgtaacagg aaggaggaaa gaattggtct    10320

caatgtggaa aagtttgttg atttgggggt gggaagtgga ggcggggcat tgtgatgctg    10380

tctcttctct gtaaagtaga aaataagttt tcagcttgaa atggagccgg aagaaagaag    10440

agggttggaa gctggaggaa agtggagaat atttgaaatt tttctttgca gagagtggga    10500

gatggagcct agtaggaaaa tacaggactg tgttgaggac cactgaggtt tgtgaccata    10560

aatttagaat ggtgccaatc tgccacgggg tgttattttt ccccaatagg gctcagcaga    10620

ccaacaagca caggggaccc tctagtttta tataccaata gcaagtcatt ctttatttaa    10680

tttagttttt tgtttgttat agcaataaag aaaaattgtg tttctttgaa atggtatttt    10740

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttc tctagattat    10800

agtgccctca cgtggctgat gcacatcatt tacttatgag tgttttcata tggatgaaaa    10860

aactgagaat taagcatggg ccttacagca cagctactaa aattaaaaaa taataattat    10920

tattattgtt ttgactaaaa ccagtactag atgcaaatga actttctttc tagatcaaca    10980

caacattgtc cagttgtaat agtgttgata tttcattatg tgtaagtaat gtgatcattt    11040

atagtaaaaa cattaggagt gagaaaagat atgaagagca cgtatttcct ctctggaatt    11100

tctataattg tgtccagatt cacaatgata aagagtgcca ctttacataa tggcaactaa    11160

atctttatta tgctttttat taaatatgaa agtcattact attatctgat actgaatatt    11220

ttcttaaata gttgttttgg tttttgtctt ttgctgtttt ttaatgtcaa ggaaagtgaa    11280

gggcattggc tatacctgca aagacaaagt gggatagggt gaaaccaacc caatatttgt    11340

aataaactgt gttctgtatg atccaggaag caattcattg agcatctatt acgcactagg    11400

gccattaagt tgaaggagac ttacatattt taacaaattt gatcttcata gcaatcctgt    11460

tacatgatta ctttttctta cttttataac caagtcaatt gagattcagg gaacttaata    11520

agtaattttg ccttagttac aaaccccaga aatgccagtg ctaacacctg ccatcttctc    11580

tcatagttca ggattttatg agcaattaca gtatattata ccctctgttt agaaaggacc    11640

ttattataag acattccacc agggtaactt ttagaatgat gttataatac atttaattaa    11700

ttacttgaat tgtcttgttg aatttttgcc agggtttaca tatgtgctga acttgcagtt    11760

ttaatgttca gttgagtctg tcgttaagaa aatttaagtt gataaattat tcactgatga    11820

actactttct ttgcatttaa tctttttaat tgctaaaggt acctaaatag cctcaaaata    11880

gttgatggct tggcctgaag acaagatcta aatatgaggt tgctgagtta tagaaatggc    11940

aaaaaaaagg gtcaataata gaataataag caacaaaata atagtaagca ctaaagtttt    12000

aaacttcatg gtggtgaagg catggtagtg cataaaagta agatttttcc attgaacttt    12060

gtcttccttg acgatattct actttattca atatgctcat tatgtgcacg attcttacca    12120

actgtgtatt tatgaccatg agtaaccctc cagactggac aaagaatgtg gagtaagtat    12180

aaatattttt caatattgac ctccctttat gtttcatatt gtgcttttaa caccttgaga    12240

cctcctcaat ttctttaaca aatcatgcta gctactgtta accagaccct gattcaaatt    12300

catttctgtc actaaatgtc ttctaggaca aagcttgtag tgggctcact tagttgtgta    12360

aattactgca gtagtttgac tgctattatc tgcagccctt tatcttcttt gtgagtctta    12420

tgttcttttg aagatcacca gtgatttact aatatctact gataaaaagt atacctagtt    12480

tttatgttcc ttttttaatg actaccacag ttctgtgtta ctagtatatg tttgatggct    12540

tttaatggtg catattttat gaaatacaaa tgcttcactc atttttgtat taatacctat    12600

ttgctcaaat cggactgaat gccagtgtat ttcagattat gtcttcatat agagccacat    12660

tatttggatc ctttaaatta attaatgtgg aaaatgcaat atacatttat ttacagtcaa    12720

tgagaatgtc ttttggaatt taatgtttct tttttgactt aagccccacc taaactctat    12780

atcgtagggg gaccaacctg gaagtgtcta atttttgttt gctgtttatg tcatctttaa    12840

gatatgtact tgtaaattaa ccactagatt tttaatgtga gcttggctat tttctctcag    12900

gtataccttt acaggaattt atacttttga atcacttatt aaaatacttg caaggggctt    12960

ttgtttagaa gatttcacat ttttacggga tccatggaat tggttggatt tcacagtcat    13020

tacttttgcg taagtatctt aatacatttt ctatcctgga agagtaaatc actggtggga    13080

gcctatacta tattttcctt ggtggcttgc cttgacagac caagcatttt tcttagtaat    13140

catagttttc ttccaatcaa attatccagt ttggagaaat taggaactat catagtaaat    13200

tacatggctt tggtttcaat tagcactgta aagtaataaa gtttcccaaa taacagagat    13260

tatgattgat gacaatgcca ttttcctctt aattgggaaa gctgatggcg acactcatga    13320

aattaaaaag gtcttgatga aagaccaagg aagacgtaga tttccctaaa ttctgaataa    13380

ctctgattta attctacagg tatgtaacag aatttgtaaa cctaggcaat gtttcagctc    13440

ttcgaacttt cagagtcttg agagctttga aaactatttc tgtaattcca ggtaagaaga    13500

aaatggtata aggtggtagg ccccttatat ctccaactgt ttcttgtgtt ctgtcattgt    13560

gtttgtgtgt gaacccccta ttacagatat gtgacagagt ttgtggacct gggcaatgtc    13620

tcagcgttga gaacattcag agttctccga gcattgaaaa caatttcagt cattccaggt    13680

gagagctagg ttaaacaccg aggctgactt tagctacagt ggtgctacaa tcacagcttt    13740

tgtgcagaag ccttgttgct agttgcatat tgcaaataaa tatgtaaaaa agcaagaatt    13800

ggtacatcat tttttggatg gatttgattc tttgcttttt actcgttgct ttctttaaaa    13860

ctattctaaa tcagcctttg agtttaacaa gtgttgcatg aggcatttgc agtaacaggc    13920

tacatggttt gcatcctata acatcaagct ttccgcatag aagctagact aagagacatt    13980

cagactgatg caaatttgac agtttaggcc taaaactggc aatcttttaa gctgcagata    14040

aatgaaagag caagggatag catgagtgct gcatggggct cagatttcag atgtcttcct    14100

ttttttaacc catactcaag cttgcagaat tcacaaatat ataacctcat aattcatcga    14160

cttcaagatt tcttactact ctattcacat agacttttct aaaaccaata aggggttagg    14220

gagtaagaca tctgcaaata aaagcaaaat atttacacaa ggttgatgtt taagcatgaa    14280

taacaaaatc attcttttgc tctaaagagt gtttggaaat acacatttgg ttcatttcca    14340

ttcacagttt tctaatgaac atacaagttc tgctttcatt cattttcacc agctagcagg    14400

cttttcatga aaatgttatt caatcacaaa cattaaacta atattgttgg cattctgcat    14460

gacattttta ttttccagga caagctcatg atatttttgc cggtaaaata gctgttgagt    14520

agtatattta aattccccct tctgattttg tttgtaggcc tgaagaccat tgtgggggcc    14580

ctgatccagt cagtgaagaa gctttctgat gtcatgatct tgactgtgtt ctgtctaagc    14640

gtgtttgcgc taataggatt gcagttgttc atgggcaacc tacgaaataa atgtttgcaa    14700

tggcctccag ataattcttc ctttgaaata aatatcactt ccttctttaa caattcattg    14760

gatgggaatg gtactacttt caataggaca gtgagcatat ttaactggga tgaatatatt    14820

gaggataaaa gtaagatata ctctataaac cattaagttg tttagttctc taaatattaa    14880

atattatata taatggaaat tatctcaatt tagatgtgaa tcaagtgact tagactaatt    14940

taagatgatt taatacatat aaaagagata tcaaatgata ccttattcta tttttcttat    15000

ctgtccattg atatagtaaa agttctcatt tgaaaatgtg ttgtcttata ctcatgttga    15060

aagtaatttc atattatgcc atattaaaaa atgtttattt ggtagacatt aatcaggttt    15120

ttcagtcatt ttaataaata agtcagtagt ttgaactatt cagtgtattc cactgaaatg    15180

tgttaagaag actgagggga aataatttgg ccctatttgg ttgatgcaac atatgtattg    15240

agtacatatg ctatatctga aaatagagaa accatttatc aagatgaaat aagaatttgt    15300

gtgctcctca gaaggttaag taaccctgat ttagccattc acttattcat attctaatta    15360

gtccctttag tgtcatcatt gtattgtagt taccagttta gtttgattat atttaaggta    15420

tgaacatcag aataagctta tgccatatac ttcagcatga tttcttaaca ttgagcccag    15480

cccctctgtc atttttcata tgtgtgtgca tgtttgtatg tgaatataaa aatacgtatg    15540

tttgcatgtg tgtgcatgtt ttctgagatc atctttgcaa cttactgaag ttatatgtca    15600

tgccttaaaa ataaaaacta gatagctctc catagcttaa aaataaaaac tagatatact    15660

cagacaacat atctctccaa agaaacaagt ttattttctt catttgaaag gcagaaatca    15720

agcaaaaatt tcaaacaaaa cacttattta cagtatcata agagggaata aatacctaat    15780

cccacttctc acaggaaatt aagttaaaat tggcgggaaa aaatgtctga atctattttg    15840

agcctgggga gaaaagtata tgtaaggtaa aatttatttg catgaaaaca cctagaaaca    15900

acaaggcttt cttctttctt actttttgtg cccagcaata gactggcagc tctttcttaa    15960

tgtatcccat gcaatttgag cttatatttg caatgaatgc tgatataaga atgttatcat    16020

agtaattcct tctgaacatt tttcttttta acatagattt gctaaccatt tgtataatca    16080

aaaatgttat atattgatat ttgttcaata ttgtgaaaaa tctctttagc catatatatt    16140

tattagttta tccatctcat tatgattgaa aacatttgtg agctttgcca cctaaacagg    16200

gtggctgaag tgttttacag gattttaatg attctttcta ttcctttctc tttaaatagg    16260

tcacttttat tttttagagg ggcaaaatga tgctctgctt tgtggcaaca gctcagatgc    16320

agggtaagtg atgcttccta ctgagtttca gtccacactg ctccatcagt gtcaataacc    16380

tgccacctcc cactcatcca gtcccactca ctcctcactc aaaaccctcc ataaattcta    16440

cttcacggtg actctcagaa tagccaggat aagtgtagat tctcacctct ttcacacagt    16500

catttactgc aattattttt ctatgctagg tcacatctaa tcttccaaat tagttcaatg    16560

taaaatagag aataaagcag tataatatgc atctgaagct taatagaatt cttaagcaca    16620

tactttttat aagtgtcata ttttatatat actaatgtgt tctccatagc ttaaaatgta    16680

agatctctga aaataatgtt aatatctgag acatggggag tatttagcat attttagcaa    16740

agtggttaca aacataaact ggagagtctg catagagtca gactttgact ccatcatata    16800

atctcatttc ttcttgcctt cgtttcctta tatgacaaat gggtataata atagggtttt    16860

tgtgatgatg aagtggatta ataaatgtat agctatttag atcgctcaat aagtgcttgt    16920

aattgttatt attgggatca tgcaaatgtt tgctattaag aaacatggag ctaaatccta    16980

ggaaaattta aaaacacagt taattttctt tatttagcaa gattttagag ccacacacaa    17040

aagtctaatg cactttcttt ggacgatgat actgtggaca ttagtagcta atacctgtag    17100

caaaattccc agtgataata ggctttccat ttggctccta cgatcagtgc tatgctgcct    17160

ttatcttcag attccaatga taagtaaatc aattgatttt cattccttgt ttgtactgta    17220

ctaaatgcgt tacatacagt atcttcttca atgtttgcaa atttgtgaga caggttctct    17280

tattagccca ttctcacatg cgaggtgcct gaagattagc aagttaagta acttgcccaa    17340

gatcgttcag ctcagaagtg tcaggcaaga cattgaagcc aggtctgctt gatcttcaag    17400

gtcctcctat gacattttta ccacacagtg tcattcactc cttgcagcat gccccaccta    17460

tccttttctc acttctttac cctgttccca cacttacaca catttctgcc tcaagacatc    17520

ctcagtgaaa atcaactttt tccttacaga cttttttaac tgcccttaag tcccagaaga    17580

tattaatcat gatatgattg cttttatatg gagacataat aaatataata atgacaatta    17640

tgaatcacag aggaatccac aaagtagacc ttatagattc tgttattata taaatcagtc    17700

cacttagtgc tgagttaagt actgggtaag gtgagagaaa tcggcttttt tctagtgcct    17760

gtataaaaca gacattggca tatattaaaa caggaaaacc aattagcaga cttgccgtta    17820

ttgacttcct ttctttcctc taacctaatt atagccagtg tcctgaagga tacatctgtg    17880

tgaaggctgg tagaaacccc aactatggct acacgagctt tgacaccttt agttgggcct    17940

ttttgtcctt atttcgtctc atgactcaag acttctggga aaacctttat caactggtga    18000

gaacagataa aatcattttt ctgagaatca taaaacaccg aactcaagag aattgctgta    18060

gaatatttta ttacttagag tgtaagtttg taacatccta tataaaattt attaaaatct    18120

ctcttccatt ttgcagacac tacgtgctgc tgggaaaacg tacatgatat tttttgtgct    18180

ggtcattttc ttgggctcat tctatctaat aaatttgatc ttggctgtgg tggccatggc    18240

ctatgaggaa cagaatcagg ccacattgga agaggctgaa cagaaggaag ctgaatttca    18300

gcagatgctc gaacagttga aaaagcaaca agaagaagct caggtatagt gaacaagcat    18360

acggtccttt gtttttcttt atctaaattc tttaacctaa atgttgaggt cagtggcaag    18420

gtagttgaca ttagaaatag gtcatatgtg tttggtaagt gctaggagcc tgtttggtta    18480

ttaagaagtt attactttat tgcaatgatc tctgtcaata gtgtcaatag taatggcatc    18540

aaaaaatgga taattataat tgctttactg acattttttt ctcccttgtg actccttgag    18600

gaaattaatg attaacaaag gcctcatgta ctcaaacttg cagagtagat aaacctacat    18660

gtcctcagtt gaagtatttt cttaggggaa gaggaattca gttacacttg cttcttcatt    18720

gcagtatcac cagaggtggt aagggtcaga aaaccagaat caaactaaga aaattatttc    18780

attgagtctg gaaaggcaaa ggcttattca atatttgttc tcttttatat aaagtgtaca    18840

aatgcaagtt tgtgggttac atcagtaaat cactagtgtg taaacatatt aaaacattag    18900

cactctctgc ctcctactct acaaatcctt taatttggac ttgacaagcc ttcaaaataa    18960

ggcaagaatt tctctaatta tatttgcttg acttaatggc attaactaat ccaattgcct    19020

atttttgtct tttcatgtat ggtgaataca attccctttt attaccgagt attcctaaat    19080

atgtaataaa ggtcaaagta tattgctgta atagcaacaa aactactgtt atactttaca    19140

agttcatgca gatgccatga tctaggattc tcaaataaac actctgtatt atgtctttgc    19200

tgtgcatttc ttagtgaaat acccaattta aatcacggag aaaaatgtca ttaaaataaa    19260

atacttgact gaattacatt taataattca gactagcact aaatttcttt attgtgtgaa    19320

aatggaatca aaggcaaatg tctaccaggt ttaaatagga agtctttaat tcccatatta    19380

tttccttctt aaaatattgt ttgaattata gaacatgtta ttatgatctt taagtgtctt    19440

gctcatatta ttagataatt agatatcata gtgtgaggac agagcttgaa ggttctcata    19500

aaagtcgtat gtatcatctt ccatatgaat gcccatttta ctctttgatt ggtctaataa    19560

caatgtactg ttttctaaaa cacagaataa aatggagaat tgtttttcaa gattatcttc    19620

atgatattga agctcaatta agcagtaaca tgataattac tttttaagtt tatatgcaac    19680

ttccacatac tttgcgccct tctaggcggc agctgcagcc gcatctgctg aatcaagaga    19740

cttcagtggt gctggtggga taggagtttt ttcagagagt tcttcagtag catctaagtt    19800

gagctccaaa agtgaaaaag agctgaaaaa cagaagaaag aaaaagaaac agaaagaaca    19860

gtctggagaa gaagagaaaa atgacagagt ccgaaaatcg gaatctgaag acagcataag    19920

aagaaaaggt ttccgttttt ccttggaagg aagtaggctg acatatgaaa agagattttc    19980

ttctccacac caggtaaaaa tattaaatta catgaattgt gttctcataa attttttaaa    20040

aaaatatgcc agaatttaat ggagagaaaa ccgccttcca cctggatggc acaatgcttt    20100

cagagtagtg atgattatca agtgttttgg ctatcacttc agagaatttg tgagttttgc    20160

aactttttgg aatcccagga aggaaatttt agatccctct gggtttggaa aaatttgcgg    20220

ttttgaggtt ttcttaaaga ctgaaaaatc ttggagaaat tttccacatc aggaattatc    20280

agcagatggt tcccatctct tcttaactat tgtgcgtgga tctagtgaac tttgggtttt    20340

ctgagtgaca aattcccaga agtggaccag agactctttt aggccacctg cggggttgtt    20400

cccataaggt gcaaacatca cttgccaagt gcattcttca tgcctttgtt tcaaagggga    20460

ctgaaacaaa atatctctaa aagtagccaa aactctcaga taggcaggta ctgagggaga    20520

tttatgacac gaaataaaaa gtggtgttta gttgtacttg attatctgtg tttcatgtta    20580

aacatgggac ttgcatttga agaatactgt gatttataaa ctgcaacaaa tattcactgg    20640

atgcctctgc cttttgtact catgcaagtt gttgaaattt taaaatttag aatcttaatt    20700

gtctttgaaa ttaccaagag aattcacagg aatacacagt acctcagaag acattttcac    20760

caggagtgaa accttaatac ctatacagta acaataacaa ttacaacaac aacattgata    20820

atggctaata tttatacact gtgttgttat ttgcaatatt aatgcattaa gcctttcact    20880

gcaaccctag gtaagttcta atttagttaa tatccccaat ttttatatgt gaagagaagc    20940

agggggctgc attctttgtt gagtacctat tttatgcttg gcattctttc tacattctca    21000

taattaatgc taacagttct gtagaatagt attattttca ttactataat gaaaaagcta    21060

ttttggatca gtaaagttaa atagttgcac aatgtcatat agcaatagaa aaagttatta    21120

tgatctttga gtgtcttgtt catattaggg ttgttggtat tcaaattttg cctggtactg    21180

aaaaccttaa agtttccact ttatcaagtt gcctatgaag aatgccttta aaaactgata    21240

aggaaattta caatataact ttatttaaaa tacacaatgg cattatactt tctcttttac    21300

ctttttataa tatagacaag ctcacataac ctcacatgtg atatatataa atttttttag    21360

gtcagcctta ttcatttcaa atccaaataa catcataaga ttgcatactt ggggattaat    21420

tcaaatttaa cataggatct ttaaatatca aaatttactt ggtctctttc attttgttgt    21480

cacaatcatg attccattag tagaaacatt aatcaataaa taggaatcct ttaaaaggca    21540

aaccccctgt ttacagtatt agtcattctg aaaaggaagg aagaaaaaga aagggaggga    21600

gggagggggg agagagagag agaggaaaaa agggagcaaa ggagggagga agatagagta    21660

tttttgccta catttttacc taagtttgtc tgaatttttg cctgaagttg tctaagtttt    21720

ggccaaaatt tgcctaaatt ttggcctaga tttgaaactt catatcaact tcatatcaaa    21780

cacttaccac agagattctc ttcaatttgc cttatttcta attgaataaa actaattcta    21840

ggcaaaatag tgaagcctga taaggctagg ctctgtcctt cctttttctg tacattttgt    21900

tcatagatat gatattctcc cagcagcctc ttcttcatac ctctacatac ctccatttcc    21960

cagctagttg ggtattataa gcaatcactg acttagaaga catggcatgg ctggctcata    22020

ttgatacttg tttcttaagc agtctctata taaaaataga gttaaagact ttattttgct    22080

tgataaagaa atagtcaaac aaatgtctaa gaggatggag agggagacag aaaaagacag    22140

agggaaaggg aaagaaagag aaagagagag gggggaaagg agaaaaggaa gaagagagga    22200

gagacagaaa accctgaaat cacaccaacc ccacttggca agccctgaaa gtaatactga    22260

aaatgtcaaa ccagatagaa gtacttaatc ttggtatagc aatggagggc ccatcgtgtc    22320

tgttagattt ttaagagttt gagaccccaa aatattagga attattgttt tgtgatgaca    22380

tgattgtgtt ggtaaccatc tctgtgtttg tattgaaaaa ctatacaatg caagccttta    22440

ctgcaagatt ataatttctt tagtagagta agtggaaata tgaattgttt ctcagactct    22500

gatttgactt gttagtgtgg taaagagggg agaagaaagt caagaatgta atctctaaac    22560

aagtttcaag ataatctgga tttttttgaa acctttataa ggtacaattg accttaaatc    22620

attactttat tatttatttg tgataagcta ggagtttagg agttttgctt tttaaagatt    22680

ggtttggtat ggggaatatt tcttactggc catctttttt gtgtgttaca gcatttgatt    22740

actatgcatt tatgtaatga atgtcagcaa aagaagttga tgctaacgga tggggcacaa    22800

tcatttctca tatagctgtc acatgtaaac tacgtttttg tatagcttaa ttcatccatg    22860

atccttgaga aacatgcaaa cttataactt attttcttcc aacccttcta tggctccagc    22920

tgaatggggt actggcagtt aaaatataaa ctcttactaa aagcgataga aacattcttc    22980

attgcaaagc atgtattgtt tgcctttctt ttttagctaa tgaggagcag tatgtcacac    23040

atcctgcaaa tcccgtaact gttatttcct catagctaat tcgaagtccc ttgttagagg    23100

agagaaagga gacacgaaaa aggatggata gtctaagaaa ggctttaaaa aataactact    23160

tgtatggaaa atgataaaag aaaagaatga atgttactaa tgtagttaat aggattaaaa    23220

agcatgggaa caacaagagg agagatgact tctgttgtgg gagcagtaag tcttcttaga    23280

agtagttcta ggccgggtgt ggtggctcat gcctgtaatc ccagcatttt gggaggccga    23340

gacgggcaga tcatgagatc aggagatgag accatcctgg ctaacacggt gaaaccccat    23400

ctctactaaa aaatacaaaa aattagccag gcgtggtggc aggtgcctgt agtcccagct    23460

gctcgggagg ctgaggcagg agaatggtgt gaacctggga ggtggagctt gcagtgagcc    23520

gagatcacgc cactgcactc cagcctgggt gacagagtga gactccgtct caaaaaataa    23580

ataaataaaa aaaaagaagt ggttcttact gtaaataatg aatagaatca cataagatag    23640

tgtttaacat ttacagacat ttaatagaaa ctaacagata ttattgagaa aaagtaattc    23700

tttagctgga aagaaaataa aaagcatact tattggtcag tgtattactc tgttttcatg    23760

ctgctgataa agttataccc aagactgggc aatttggcaa aggaagaggt ttaattggac    23820

ttacagttcc atgtggctgg caaagcctca caatcatggc agaaagcaaa gaggagcaag    23880

ccacacctta catggatggt ggcaagcaaa gagagagtga aagccaagca aaagaagttt    23940

ctccccatat aaccaccaga tctcatgaga cccattcagt accatgagaa cagtatgggg    24000

aaaaccccta ccatgattta actatctctg accaggtccc tcccacaaca gtgggaatta    24060

tgggaaatat aactcaagat gagatctggg tggggacaca gagaaatcat gtcattccac    24120

ccccggcccc tcccaaatct catgtcctca catttcaaaa tgaatcatgc cttcccaaca    24180

gtcccccaaa gtcttaactc atttcagcat taattcaaaa gtccacagtc caaacaaagc    24240

ctcatcggag acaaggcaag tcctttccat ctatgagcct gaaaaatcaa aagcaagtta    24300

gttacttcct agatacaata gggatacaga cattagctaa atacagccat tccaaatggg    24360

agaaattggc caaaacaaag gggctacatg ccccatgcaa gttcaaaatc cagcagggca    24420

gtcaaatctt aaagctcaaa aatgatctcc tttgactcca tgtctcacat ccaggttacg    24480

ctgatgcaag aggtgggttc ccttggtctt cagcagctcc acccctgtca ctttgcaggg    24540

tacagcttcc ctcctgacta cttccatggg ctggcattga atgtctgtgg cttttccagg    24600

tacacggttc aagatgttgg tggatctatt attcttgggt ctggaggaca gtggctctct    24660

tctcacagct ccagcaggca gtgccccagt agggaccctg tgttggggct ctgaccccac    24720

atttcccttc ctcactgcct tggcagaggt tctccatgag agccctgccc ctgcagcaaa    24780

cttctgcctg tacatccagg tgtttctata catcctctga aatctaggca gatgttccca    24840

aatcccagtt attgacttct gtgcactgac aggctcaaca ccatgtggaa gctgccaagg    24900

cttgaggctt gcaccctctg aagccatggg cctagctcta catttgcccc tttcagccat    24960

ggctggagcc gcagagatac agggcaccaa gttcctaggc tgcacacagc gtgggactct    25020

ggacccggca catgaaacca ctttttcctc ctaggcctcc gagcctgtga cgggaggggc    25080

tgctgcaaag atctctgaca tgccctggag acattttctc cattgtcttg gggattaaca    25140

ttcagctcct cattacttat gcaaatttct acagcctgct tgaatttctc ttcaggaaat    25200

gggattttct tttctgtcac attgtcaggc tgcaaatttt ccaaactttt atgttctgct    25260

tcccttatga aactgaatac ctttagcagt acctaagtca ccacttgaat gctttgctgc    25320

ttagaaattt cttctgccag atactctaaa tcatctctcc caagttcaaa gttccacaaa    25380

tctctaggac agggccaaaa tgccaccagt ctctttgcta aaatataaca agagtcacct    25440

ttgctccatt tcccaacaag ttcctcatct ccatgagaga ccactttagc ctggacctta    25500

ttgtccatat tgccatcagg cttttggtca aagccattca ataagtctct agaaagttcc    25560

aaactttctc acattttcct gtgttcttcc gagccctcca aactgttcca tcctctgcct    25620

gttatccagt tccaaagctg cttccacatt tttgggtatc ttttcagcag cgtcccactc    25680

ctggtatcaa tttactgtat taatctgttt tcatgctgct gataaagaca tacctgagac    25740

tgggcaattt accaaagaaa gacatttaat tggacttaca gttccatgtg gctggggaag    25800

cctcacaatc atggcagaag gcaaagagga gcaagtcaca tcttacatgg atggtgtcag    25860

gcaaagagag agtgagagcc aagtgaaagg gatttctccc cataaaatca ttagatctca    25920

tgagacttat tcactaccat gagaacagta tggagaaaac tgccactatg attcaactat    25980

ttcccaccat gtccctcccc caacaatgga aattatggga gatacaactc aagatgagat    26040

ctgggtgggg acacagccaa accatattag tcaggcatat aaaaacctag atattagtag    26100

gtataaaata atggttttag ttagttttga acctttggag aggaaaagat caaaccaata    26160

atacttaaat gatgaagtta gtattctttc caataataat tacataaatc caatgcaagc    26220

tggctgaagt aaaaaagaga atgtattaga tgatataaat tatgtctgtg agtagcttta    26280

ggcatggatg gatccagaag ctcaagacat gttaccatga ccatgtcttt ctccatatct    26340

gaatctaggt tcctcccaca tggtggcaag atgtcactgc agctccaaac ttaaagccaa    26400

tatttttagc agcctcaagt gaaaaagcac catttcctca acagttgtaa aagacaggga    26460

tatctttcaa ttgaccaagc aggatttcat gaccatcttt aaattacgta tcgaatacac    26520

tgattggcta ggcctaggac agtgcctgga acactgggag acccgagcct caagtcctgc    26580

tgcatccagg agttgaaatt agtgtctccc agataacctg gtctgagagt tgaggattat    26640

ttctcaaggc tgaacagggt actgatttaa aaaaacaaaa aattaaatgg ttgtgatcag    26700

cctcttagtg aaaattaagt ttttgtaaat attgccctca gatttcttga gacagagaca    26760

aaggggtgaa aattggggaa taaatcatac agttatttca gcttgattta atttattcat    26820

gaagaccatc ataaaatatg caaagggaag tggagaagct gccccgtgta ctataattaa    26880

acatccctac tagcaagatt aattatattt cctccatggt aagatttgca tcagggtgtg    26940

gtcactagcg agctcttact ggctacattt ttgacctcag aggatctaaa ggtagatttg    27000

tgtttaattg ttttccattg ggttgttaac tgaaattaac ttctaaagaa gggtctatca    27060

acagtatcag ttctagatgc ccgtaacagg acaaaacatt atggggacac ttctgactat    27120

gttgaggtgt gggtaaagta ggagaaaaga gagcagaaga tggaaaatgg aggaaggaga    27180

aaaagcgaga gtgaaataga aaaggtgaac cttgtagaaa gtgccaaaat gccaccagca    27240

gtcatcagag gggtgctttc ttccacatgt ccaatgactt atccttgagt aagtcaatga    27300

ctatgacaca atgaatcaaa ttctgttttt cagaatgcca gctcttaact ctcttcatct    27360

catttttgtt tcttctcttg ttattcatag tccttactga gcatccgtgg ctcccttttc    27420

tctccaagac gcaacagtag ggcgagcctt ttcagcttca gaggtcgagc aaaggacatt    27480

ggctctgaga atgactttgc tgatgatgag cacagcacct ttgaggacaa tgacagccga    27540

agagactctc tgttcgtgcc gcacagacat ggagaacggc gccacagcaa tgtcagccag    27600

gccagccgtg cctccagggt gctccccatc ctgcccatga atgggaagat gcatagcgct    27660

gtggactgca atggtgtggt ctccctggtc gggggccctt ctaccctcac atctgctggg    27720

cagctcctac cagaggtgag gccaattaaa attgcagctg atgtgaagag agttgtgact    27780

ggtgcaggca ggagtgtttt tccatttcca catctaagaa tttgttgagt ttgttgccca    27840

aaggctggga gtttgttcaa tcaagctgtt aactgtcttg tgaaactgtt ctattcagac    27900

ttttctacaa agtaattaaa aacctaggtt ggctgtcaga gaatataatt agaagtaatc    27960

tttcatcatt attactatgg tatgaaactc gccaaaaagc aaagcaacaa tttatcaagc    28020

ataatgtttg attaatatag ttaaattaaa tccaaggaaa ttaatgctca ctaattaaat    28080

aaatacttaa ggattttgtg attgttgttc atttaaaagg agatttgaat acttccactt    28140

gcagtagata ctattactaa atagatttaa atcccatagt acaacattgc ctctctttgc    28200

aggtcagagt gttgtaacct ttttagcatc cactctaatg atctcaacca ttgtaaattt    28260

atacatgaag agccattcaa aaagtacctg gtttggaatc atgggctgtc atttttagag    28320

cagattccaa tttttatatt actgtcataa actcttattg taaacaaagt ggcccaaaac    28380

caatcacatg gaaaaggatt tcagctacat actagacact tacagggcta tattattgaa    28440

atttacttca taaaccataa gaagctttta atgttggtat taaataaaat tccattagct    28500

atcaagacat attttggcaa tgtcacttga ttgtatttta tagcattcaa aatgtcttct    28560

tatgattttt ttttcacata gctccattta ttatcattga acaagctctt tgagccacat    28620

taaaatgata cggagttcgt tttcagttac ctaatggagg agcttcttat cttggattat    28680

aaaatagcca ttatcttctt cacatttttt gcatggcctc tccccacctc cttctaccag    28740

agaagtgtcc aggtatcctg cagtcaggtt gaaccatgag aaaagtagaa ctttatagtg    28800

gaggaaccag gaagaatgaa gagaggacat cagctcttct taaaaaatga tcatagataa    28860

ccatgtacca gacactgtcc agaacactgt acatgtgtta agaatcattt aagcatcata    28920

acaacccttt ttgatagtta gtaacattat cccaatttta cagaggagga aactgaggct    28980

tgtgcgtggt ggagctaaga tttgacccca ggtatgctgg ttactgaacc tacattctat    29040

caacagtgaa atattgcctc ccactgagtt atttttaatt tctttaaatc aaaaagaaga    29100

gatggttaag gaaataaaca cataaacact ttcattttaa ccaatgtttc tcaaaatata    29160

cttcactttc atactactta catcagaatc tcatgggagg cttcttaaaa ctagagattc    29220

ctgtgcctac ccagaccttt tcagaccaaa ccactgagga gaacaaggtc tgggaatctt    29280

cttccttaac aagcatccca cataattctt atacataata aagtatgttt atcactgatc    29340

ttgataaatg ttaattgggt aaacaaaagc aaatctacaa ttaccatgca ggaatacaga    29400

cagactgtca gtctgtcaga aattatttag catttatcaa taattatcat aaatctcctg    29460

tcctatcaga gatgatggga caaatcgctg aaggcaaagt tggggccagc ttgaagcaaa    29520

gctttgtgtg gtccctttat ttcctgcttc ctcaacttca ttctttaatc ttacaatctt    29580

aagtgctttg aggcagggca ctgtactatt gcaaagttga gctgaaggtg caaacaaatg    29640

aagtaggctt ttggagaatg cagaggtgaa atgacaatag aaaataaata gctatgggca    29700

aatgacaccc ttgaaagcac atcatttcct gtactttaca cataaattca atcgagtaat    29760

gtcattagca gttttggaat ctatttgaaa attagacaaa tctaggtttg tacatgtgct    29820

tctgtgtaga acagaaggga ctagatgatc ttcatgtgac tatttttttt ttccttaaaa    29880

ctttgcctct ttctgacaag ctgaaatatt ttaaattcta agaggcaccc tttggattaa    29940

aagactttta tttttagaga taggttattt cttttcttac taattttact tgttttttta    30000

ccttaaaatt aattttagaa tgacctatat gaatagttat caccattagt gacaatcata    30060

tgcaatgagt ggaaattttg gttttgaata tgtatgcatt aaaataattc aacttacaaa    30120

agataaaata ctgctaattg ttcacatcat aataggatgt gaccaaaata aataatattt    30180

tgatcatatt attatatttt gatcatattg ttcttttaga aatagggaaa gtcctcaaag    30240

gaatgaaact ttttaattta ttattaacac tcagacctgc atttgaaatt ctttagcttt    30300

accttttttt ttcctgtgat aattgacatc attgtttgat ctcctgaagt aggaataaat    30360

ttccacccat gttgaaatcc tgatgagttt attctggagt aggagattat cagatcattg    30420

tatcattact aaaaatcaca gtcccccaca ttggtattat ctccttaaat tatagtctca    30480

gtgccaaggg tggattgttt tgtggattaa gttgtttttc aaatatagga caaagttata    30540

gactagttct aaaatttagt tttgtaatta ggaatgttgg gaaatattac ctgtgtctaa    30600

tgaatgaagg cattttgcaa ctggaattca cattttaggg gaactgttac tgatgcatat    30660

gaaggagact ttcaaacctt tttgttcata tattaaacta cctgaatata tgtctataaa    30720

gatctaaaaa ctcaacctgg gtgaaaatta agaaacaata tgttttggtc tgaagtccta    30780

agtgggattg gctgaaatgc taaaaggtta tctgtccagt agtggacctg gtccctccag    30840

cccaaatccc tgggatagag gcataggaaa gcccaccttg acaaacccag ggctccccaa    30900

aagctgaaaa tctgacagac ttttaaacaa cccccaaaga attatcattc caacaatatc    30960

ttagtgagct ttttacatct gagaaagcat ggtgtatatt tagttaaata acacctgttg    31020

taggaatgct ttgggctttg ctgctttcaa aaatagtggt tatttcatct gaaattctac    31080

ttctagggca caactactga aacagaaata agaaagagac ggtccagttc ttatcatgtt    31140

tccatggatt tattggaaga tcctacatca aggcaaagag caatgagtat agccagtatt    31200

ttgaccaaca ccatggaagg tatgttaaaa gtcctgcgtc acagttactt ggtgctttgg    31260

taatgatgaa aaaacacttc ataaatttca ataaaatact tcctgacttg atattgtatc    31320

attattacac attttactaa ataacagtaa aatccgtgca taactcatgg attctattat    31380

cttccacaga tttttttttt ttatatttag cctccagaaa gctgctgcaa atgtaaggta    31440

tattttgaac accactttca tacattaaat tctaaacatt gaaacttgtg tgcatgacgt    31500

tgaaaagagt gtaatgataa atgcttatac ttatgatgat gctaagccat ttggattata    31560

ttaactgctt gagacacaag ttataaaatc ctatgactta accagaaata taaattaaaa    31620

atgtgaatta gggtttgata ttaacttcct tgaagcaaag tgtttaaaat tttgtagtcc    31680

tacttttgcc tttctctgac cagattctta caatatatca gctttctctt tagttgcaga    31740

ttttatctga atagttaaca taatgtgtag cagtctggat ctcagaatgc caaaataaag    31800

actttgggga cagcttaatc tgtgatcaat ttctggctct gccatatgtt aaatgtgtta    31860

atttgtgact ttgaatttca gtctcctcat cagtaaaatg tggatgatga tgtttaggca    31920

taaggttgtt gaatggatta aataagcctt cttagataaa acactgatgt atttggcatg    31980

cagaagacag ttaataaata ttatcaatat tagttgtttt gttgttgtta tttttgttaa    32040

ttcacatgtt tttgcctttc catactgtaa gtgaattcaa acaactgtca acttcaacta    32100

cttggaaaat attttcatgt aaaatgtatt ctatccccct tccttgccct cctattccct    32160

cctctcccta tctctttaca aaccttctcc cttgtacccc ttcccaggta tgtgtgtgag    32220

tgtgagtgtg tgtagatgtg tcaagggaga agagaaaagg agaatgaaag caaaagagag    32280

caagcataca cgtccctttc ttattgataa ttagattttc tcttgagatt ggatagattc    32340

ctggaataat tcttttcctg tctgtatgca aagatcccat aatattatta ataccaatac    32400

gaaaagcctg aaaatcacag ccagaaaaaa ttcacagtgt agacgactgt gtacatcaca    32460

gacaagtcag tattacaaaa cccaattttc atagtgtcct atttcagtat cctaatgcaa    32520

ttcactgatt tcaattgaat attaaactct agtacgttct tccccaacct cgcctgcgtt    32580

agcttgcact ccctcttccc cccagctgcc agtagcttgc tcctccctgt ccctccaggt    32640

aaatcttttg aagattgtct ggccttccgc tccttgccat agcaaaacca ctgagaggaa    32700

gctgccagtg gttctgctac cgatgtcagc agcatgtctg ctccctaaag caggaagtag    32760

agaaggagac agggtaagtc taaatcaaca gtcatgcttt gcacttctga tagcattaag    32820

tttgagctaa ataagacatt acttaaaaaa cctcaaatat ccacaagatt ggacttgcca    32880

actaattaag atttggagtt caaaataaat gcacccacac ctttctccat ggaactatgt    32940

gacatggggt tgcttaggat ggaaaggatg ttctaggaat aagtgcaatc taggaagctg    33000

aagactgaga gtgttttcgt tttattatct gcagagcttt tgacttgtgt atttgtgaga    33060

aataatggcc aagtttttat tctgttttta atcagttatc tagaatgaaa actgactttt    33120

ctttattcaa ttgtatgtag acacattgag tgtgacattt gtcaaggttg gttgttagca    33180

atatcacata catgcatact caagcagact taagatagtc cttttttttt tttttttttt    33240

ttttggtttc tgataatggt gcaaagtttt cctggttgac ataatctctt ttcttgggga    33300

tcctttcttc tatgtctgat tattgtttat ttcacctttc ctttttatga accaggcttg    33360

ttgatccggt tggcaatttt tgttctcctt ctttttaact acagccaagt ctccgttgtc    33420

cagggtaatg gatagcctca tgcttaatga agcagtagtg gataagcaaa aatgaaccat    33480

ttgcgtttca aatttttaaa agtgcaaaat cacatagaaa tgttttctgg tcacaccttt    33540

gtgaaggatg gtgggagggt gagttagaag cgcctgaaga atcaaggtga gccagcaaaa    33600

gacacagatt tactgtaagt gattctatgt ggataaccca tgcaggaata atggagatgt    33660

ggctgcagtt ctctcctgaa tgctttgctt tgttttaaag tgtgagattc cccccttttt    33720

tttggaatga ataattgaat gattttattt tagaacttaa acaactttgc tccggttatt    33780

cctactgtca agatgagcca cacctgctga atttcatttt ttaaactttt ctccagttta    33840

ttttttttct atccagttcc tgtttgcttc tcgttatttg ctaaatgaca gctggcatgg    33900

aaagaaaaaa ccatattatg gcagtataca gacaaaatta aattttgtag tttctttttt    33960

gttatttact gtaaataata atacctcctt tttaccttca atgtaaatat aaggttattt    34020

gggagtttag aagtatttac aaaataacta gtgcataata actatatttt tctctgaatt    34080

ataaatcaaa tattatttat tgtttacaaa gttatgtatt aagggaaatg gaaacaaact    34140

gggcacttga agaatttcaa tatccaaaga gacaattgac aaatctattt ttagtggaaa    34200

ttttaaaaac aataagcaat aaattaattt acttaggaaa atagtattat agaattaatt    34260

agtggcaaat gttgattagt agaagaaaca ttatcatctg tggttgtgat tgtcctttta    34320

tatgctggtt ccacctttac aaggtttagt tcatagcaaa ctgtgccaga tatggacaga    34380

tgttccagtt gccacaatag tattaaagtg actgactaga gtcaactatg ccatggattt    34440

aaaaagaaga aaccttccct ctatttcagt gctaagaggt ggtggccaca ttttggcaga    34500

acaggtaata gggtgtacag caatgatatt gacagaaaac aacaaattct gcatattttt    34560

ccactcataa gttgatgaag agattatctt gccaaaggaa gatggtagac agtttttcac    34620

ttcctaattc cccaaatttc tttgccaata ttcaccaaat ttcagtattt tgggtgtgac    34680

cttaaagatc tgtgcatttc tgtcttctct cccaatgttt ggttgaaatt cttcttgaca    34740

tcattgtaca ttttccttga ataaatgcat tttaatataa aattttatgt catgtttgat    34800

atgagagtta tatatttaaa tacatttaaa taaatgttta ccatgaaaat gtatgaatta    34860

tatgtatgtt tcacctaaaa tcctttgtat ttttccagta ataaatgagt tccactttgt    34920

gaaatgttga tttgtaacaa cagtgaggac tccagttcct taggctgggg tattttctct    34980

tcttttatgc cctctagtta aatgagaaat gtagagagat ggaactttgt tgtgtctaat    35040

atgcaagcct ataatctaat aaaatttaat ttgagacttt taaactgaga ttggtgacac    35100

tgacaaaatt atctaattag aagatcacca aaacatatct aatccaagaa actgacattc    35160

agtgtgactg attaaggttc ttaggacatc tcctgagata tctctgataa catatatact    35220

tcttgctcta cctggaacat ggatgagctt taagtgtatg caatgcaagt tctacccatt    35280

agtttctagc agccttgaag ataagtatca gacagtttag tgttgccaat agaatcttgg    35340

aagctatgtt tagccaggat acatttggaa agcttactag cctttctgta ctgatccttt    35400

ctatgacagc aaacccattg taaaattttc cctgttcctc cagcagatta acccataata    35460

tcttttaaca actttagatt ttttaaattc cttttaattt aaaccaaatc tgcttaatag    35520

aaagtaagca gttttcatga ggattctaac tttttttctt ccagaacttg aagaatccag    35580

acagaaatgc ccaccatgct ggtataaatt tgctaatatg tgtttgattt gggactgttg    35640

taaaccatgg ttaaaggtga aacaccttgt caacctggtt gtaatggacc catttgttga    35700

cctggccatc accatctgca ttgtcttaaa tacactcttc atggctatgg agcactatcc    35760

catgacggag cagttcagca gtgtactgtc tgttggaaac ctggtaagcc tcactgagag    35820

tttctcttcc tcttgaaaga gtttataatt gccttagtga attttacata ttgctctcaa    35880

attaaatatc aactaattgg ccatgtatat cttgacatca aatgtttagc atccctttta    35940

aataacaaaa aaatgttgct accatagtgc aaaagagtca aagaatttat gtacaatttg    36000

atttagaatt gaatttaaat tgcttattta ttagaagatg attctgaatt gtcctccaag    36060

gacattgatc tatagcaaaa ttctgacata tttttaagaa ccttagaata ggttctttag    36120

gacatgtctg tgtttactaa acaaatgata aaatatgccc aagtcagata attttgaaat    36180

atcacttgta agtacttgaa gatggactat gtagggaggg gacatcatct gggggattat    36240

tattttttgt ttttgtttct tctacagtct tagcaatatt aaatttagaa attatttatt    36300

taattttgtt aaaatatata ttagcattta ctggatacat attgatatta taatatagta    36360

tactatagtg atagatttta aagtggtctt atacagagag acaaaatgaa gaaaatcacg    36420

caaaaaagta tatttataca agtataaaat gcttattaag ttcccagctt gataaatgaa    36480

catataagca ggttatatag agattgtaaa taatacggtc taaagtataa tatacaatat    36540

ttttaggctc tgaagtaacc actatatttt cgaattatat ttcaggtagg acttaactga    36600

attaaatgat aaagttggca tatgttggcc tcttattttg tatcagatat tggactaaat    36660

ggtttacatt aaatctctct ctctagattc ccacaaaacc agtcttaaga tatttactat    36720

aaattgtctg tatttcgcag ttgggaaact gtatccatga gaaattaaca gagaaatgga    36780

aggtctgaat gctgtatcag actctgaaag ctatttcaga gactatcata agctatgggc    36840

aaagatcaca gacgcttaga gtaggaaagg ataataattt tacctagttc aaatttagag    36900

ctatgtaaga atttcttcaa cattatttct aaaaaaaagc agggtggtgg ggtggcaatt    36960

gaaacaagaa agcctttgga ggtaatatat tgtgatccaa attgaatgag cttaagcaaa    37020

aataaaggga attcattacc tcactttact gaagcccatt tggaactagt tctaggttct    37080

aacctggcta gattcaggtt ctcagccagc atcattggga atcagcttct tgtctctctt    37140

cttcccaata tgtgaccttc ctctctggct gggcattttc ctactattgc caagattcta    37200

tcaactttta ttctactaat gtagctccat gtacagaaag tttgtgcctc ctaactagta    37260

gctttaatta aggcccacaa attgaatatc attgacctgg ttggagttac atggccattt    37320

ctaaaccagt cagttaccct agctcttggt tttaatgcca tattcgccta aatcagaatc    37380

atatcttatc actggaggca gagtaaatga gtgaaattat gaagacaata attaggatac    37440

cattaccaga aggaggatgg attctagaaa gaaataaaca ataaatagac aactcaagct    37500

ggggctggtc ttacgtgtta aggaatgtag gatctgtatc taaggtgaat tatggaatag    37560

tagaaaatcc ataggcagga tacacattct tctcaaatgc ctataggata ttccctagga    37620

taagttatag gttaggtcat aaaacacaca tcaataaact taaaaaaatt aaaataatac    37680

agaatatttt tctgataaaa aataaaatga aattagaaac caataacaag tcaatgtgga    37740

aaatcacaaa tatttggaaa ttaaacaact tgctcttaaa taaccaatga gtcaataaga    37800

tgtcatgaga gaaattagaa aatactttag gatgactgaa aatcaaaaca aaccaaactg    37860

aaattaatga gggcagctaa aacaatattt aaagacaaat ttatactcta aatgtctata    37920

gtaaaatagg agatttccca aattgctaat ttaagctcct ttttaataaa ctagataaag    37980

aatagcaaat taaacctgaa gttaacagaa aagacaaata ttaaagaaga gaaaaacaac    38040

agagaaaaat caataaaacc aaaagttatt tctttgaaaa aatcaacaca attgacaaat    38100

ctttagttgg gctaaccaag aaaaaaagag gaaagacact aattattaga agtaggaatg    38160

aagagaggat attaccatgg atcttttaga aagaaaaagg gagcataaga aataaaataa    38220

aattaaacgc cagcaaacta gataacctat gtgaaattga aaaattccta gggagtaaca    38280

agcgcctgaa actgactcaa gaagtaatag actatctcaa tatacttata ataagtaaac    38340

attgaattca caattaaaaa aaagaaaact tcctgccaaa aaaagcctga gcccagatag    38400

tatcactggt gaattttgcc aaatgttcaa tggagcgtta acatcaatcc ttaacaaact    38460

gttccaacac atagaagaga agggaatact tctcacctca ctttctgaag ctagaattac    38520

cctgatatta atgccagaca aaaataatgc aagaaaagaa cacagacaca aatatagacc    38580

agccatatcc catatgaaca taggcacaac aatcctcaac aaaatactag aagccaaatc    38640

acataacata tttagatttt tagattatgt actctgaata agtgaaattt atcccagtga    38700

tgcagggctg gaccagcata aaaaattaat gtaatatatc atattaattt taaaaaacta    38760

tacaatcatc tctatagatg ctgtaatcac atggaaaaag ccaaagtgtt tcatgataaa    38820

aacactcagc aaacttgaaa tagaaaagaa cttcagcctg ataaacacca tctcaaaaga    38880

ccccacacct atcatcattc ttaatagtta ctttagatgc ttttatcttc aggtcaagaa    38940

gaaggcaagg atatttgctc ttgctacttc ttttcaatat tgtactgaaa gttctaacca    39000

gggaaataag acaagaaaaa gaaattaatg gcatctagat tggaacacaa gaagtaaatt    39060

ctattaacga atacataatc ttgtatttag aaaatcctat aaaatacaca cacacacaca    39120

cacagctgtt agaactaata aataagattg cagaatacaa gatcaatata caaaactcaa    39180

ttatatttct aaacactact aatgaacaat cagaaaataa aattaggaaa attctattta    39240

taacaacatg aaaaataata aaatacttag gaataaattt aataaaataa gtgtgagatt    39300

tgtacactca aagctataaa atattgttga aagaaattaa agaactacta aataaatgaa    39360

agcacatttt atattcatag attagaggaa aatattgtta agatggcaat actcaccaaa    39420

ttaatctaca aatttaacgc tattcatatc aaaatcccag ctacctattt tgcagaaagt    39480

gataaattga ctgtaaattt tatatgaaaa tgcaagagac tatatgccac acaatcttaa    39540

ctagaaaaaa aataaagttg gagaactcaa acttccaaat tttaaaactt actacaaagc    39600

aaaagtaagc aagatagttt ggtactggca taaggatagc tatatacatc aatggaataa    39660

aattgaaatt ccaacagtaa gtcttcatat ttatgttaaa ttaattttca acaagaccac    39720

tagacaattt tattaaggaa agaagccttt tcaacaaatg gtgcttggac aagtgaatat    39780

ccacatatga aagaatggaa ttgaaccctt acttaataac atatataaaa attaagatag    39840

gtcataggcc taaaggtaga gctaaaacta tgaactgtta gaaggaaatt tagaagtaaa    39900

tcttcatgac ctattattaa gcaatgattt cttagatatg ataccaaaag cacacacaat    39960

agcaataaga aaaaaaaggt tcattggact ttatcaaaat tagaaacttt catactgcaa    40020

acaatatcat caagtaaaaa gacaacttaa agaatggaag aagacatttg caacccagat    40080

atctgatcat gatttgtatc taatatatgt aaaggattat tataactcca caacaaataa    40140

aatagataac tcactaaaaa tgatcaaaat atttgaatag acatattgaa aaaggagtta    40200

gacaaaaggc caataagcac ataaaagatg gtcagcgtca ctggctaatt ttaggggaaa    40260

ggcaaatcaa aactaaaatg agataccact tcacacacac taagatggct ataatcagaa    40320

agaaagccaa taccattttt tatcaaggat gtggaaaaat tagaatggtt atgctttact    40380

ttgagaatat aaaatgatgc agtcactttg gataataatt tagctgttcc ccaaaaagtt    40440

tggggtagag ttaccacatg acctggcagt tttactaatt tcttcggata tatatatcta    40500

agagaattaa aaacatattt caacatgaat gcttatagaa tattattcat aatactaaaa    40560

attaaaaaca attcaaatgt ctatcacttg atgaatggat aaacaatatc catccaataa    40620

atgttattca tccataaaaa agaatgaagt attgctacaa tctacaacat gaataaacct    40680

tgaatatatt atattaagtg aacaaagcca gtcacaaaat ttacatatca tattgctaca    40740

tttatatgaa atgttcataa caggcaaatc catagagaca gaaaggagat gagtggttgc    40800

caggcagtag ggattagggt aaatgggagc aacaactaac taatgggtat gcagcttctt    40860

tttaaggcga tgaaaatgtt ctaaaattca ataatggtga tgattttaca agtctgtgaa    40920

tatattacaa gccactgaat tgcatactaa tatttcatag tatgcatgta tcactatttt    40980

ttcttccaat cacctattga tggatgttca agttgattcc agatacttta cccccatgtt    41040

gcagtaaatg ttcttgtata tatcaccttt cataatgctg tattaacttc tagaagatag    41100

atttccagga ttgaagtatt cccaatatta aacatattca tgtcacataa aaattagatg    41160

atatgcaacg aaatagggaa atgtgactca tagttaatag attaaagcgg tacatagaaa    41220

tagatctgga caggaacaaa ttgttagaat aaacaaaaaa ggactttgga ggcactattg    41280

taaatatgtt gagcaattta aaggaaaaaa aggggtcata aggaataaac agagaacatg    41340

agcagaaaaa aatgaaaact gtaaaaagga ataactcaga cattttataa ttgaaaagta    41400

cacattctaa tatgaaaaat tcactggatg tgtttaaaac aaaattgcag atgtcagaag    41460

aaatagttgt taacttggag cacattaata gaaattatcc aatttgaaca ctagagaatt    41520

aaaaggaaaa atgaactgag tctaactata atatgggata atatcaagta gtctaaatat    41580

ttatataatg ggagaatcag aaggagaaaa tagaaagaat ggaacagagc aaatatttga    41640

agaaacaatg gccaaaaatt tcccaaagtt ggtgaaaaat agtaacttac agaccttaat    41700

gttaccttat aaaatgttag tgaacatcaa caggataaat ataaagtaag ccatacttag    41760

gcacatctta gtcatgctgc tgaaaacaac aataacaaaa agctttggaa acaaccggaa    41820

gaaaaatatt tactatatac atgagactaa tgtcttacca gaaataattc aggccagaag    41880

aaagtggcca gataaaataa agaaataaaa gcccattatt ctacagaaag tgaaactatc    41940

catcagaaat taaaatgaaa taaagaattt taagataaac aaaaacctaa aaaagctgtt    42000

accaccagaa ctacactaca agaaatgtta atggaagttc tttaggccga ataggaaaaa    42060

tatcagatgg aaatttgttt ctgggaatga tggtcactag atatgaataa atgtgggtaa    42120

atacgaaaga ctatcttttt ttccttaatt tttttcacat ttattttagg ttcaggggta    42180

tgtagacagc tttgttgcat aaataaattg taaatcacag gggtttggca tacagattat    42240

ttcatcatcc aggtaataag catagtactc tatagatagt tcttcaattc tcatcctcct    42300

tccaccctcc accctcaagt gtctgttgtt cccttctttg tgttcctgtg aactcaatgt    42360

ttagttccca cttataagtg agaacatgca gtatttggtt ttctgttgct gtggtaaatt    42420

ttttaaaaag acaactgatt gtttaaagtg gggatttata acataggtaa gtgtaaaatt    42480

atgaaaagat ttgaactttt tttttttttt ttgagacgga gtctcgctct ctcgcccagg    42540

ctggagtgca gtggtgcgat ctcggctcac tgcaagctcc gcctccccgg ttcacgttgt    42600

tctgctgcct tagcctcccg agtagctggg actacatgca ccagccacca agcctggcta    42660

attttgttgc atttttagta gagacggggt ttcatcgtgt tagccaggat ggtcttgatc    42720

tcctgacctc atgatccgcc cgtctcggcc tcccaaagtg ctgggattac aggcatgagc    42780

caccacgccg ggccagaaca ttttatctaa agtgttacaa tattaatttt acatagaaaa    42840

ttacaagaaa gtatccctca tgaacacaga agcaaaaaat cattagcaaa atattatcaa    42900

taaaatctag caatagagaa aaaagtaata aatacttctt aaacatgtgg ggattatctc    42960

agaaaagtaa gattcattta acatttgaaa agtgatcaat taattggcca tattacctct    43020

aaaagaataa aggaaagcct aagatcatct caatagatgc agaaaaggat ctgacaaaac    43080

tcaacagtca tttgtgagaa aaactgtcag taaactagga atagaaagta gctatctcaa    43140

gttgttaagg acgtttcaga aaaccctaca tctagccggg cgtggaggct cacgcctgta    43200

atcccagcac tttgtgaggc tgaggcagtg gatcacttga ggtcaggagt tcgagaccag    43260

cctggccaac atagtgaaac cccgtctgta ctaaaaatag aaaaaattag ctgagcgtgg    43320

tggcaggcgc ctgcaatacc agctaacagg gaggctgagg caggagaatt gcttgaaccc    43380

gggaggcgga ggttgcagtg agccgagatt aagccactgc actccacact tcagcctggg    43440

caacaagagt gaaactctgt ctcaaaaaaa aaaaaagaaa aagaaagaaa accctacacc    43500

taatatttta cttatcagtg aaatgttgag gtagtgaatt cttgcccctt agaaaaattg    43560

agtgctttcc ccttaacata gacaaatatg tctattttta ccatttttat ttgaccttgc    43620

actggaagtt ttatcaactg aactaaagga aaaaaaaaca aaacaaataa aatgcataaa    43680

tattgaaatg tggtaaatta tctatttcat caacatgatc atattgtaga caatcctaat    43740

aaatctttaa aactgattag aaataaacgc gatattaaat attttattta ccataatatc    43800

aaaaaacacg aagaatatag taataaattt aacaaatcat ttcgagacac ctattactaa    43860

aaacctcaaa acatggctga gaataattac agaagattta aacaaatgga aatatatatg    43920

ccatgttcat gcaatggaag attcaatatt attaagaaat taattctacc caaatgtatc    43980

tatcaattca acccaatccc agtaaaaatg tcacagattt tctttgtaga aattgatgaa    44040

ctgactttct atgcaaatac acagtgctta aaattgccaa aacaatactg ataaaagaat    44100

aatgaaaaca ttaacctacc tgacttcaag gcttgttata aagctgtact aatcaagaat    44160

ctacagtatt ggcataaaca aagatatcaa tggaacataa tgctgagttc ataaatagat    44220

ccaaactaca tgtcaatgga ttttttgaaa taaacactac agaaaggaaa tagaagaaag    44280

gaagtgtttt caacaaaata tcaggaacac ataaataaat gtatggaaaa taaatgaacc    44340

tccacttcga tcttatgcca agtgccagaa tcaataagga ttgtagacta agcagaaaag    44400

ctaaatcaat aaaacatctg aaataaaaca caggagaaca tctttgagac cttggggtag    44460

gcaaaaattt attggaaaac agacaaaaag tgctatctat tatttaaatg tccatgaaat    44520

ttcaaacaat ggagacctac tgaacaaaaa agaaaagtct agtaatatac acatgggtga    44580

atttcaattt gaagtattca agtaatattt ggaaaagtca ctaagactgt caggtctctg    44640

aggtaaccac ctaggtagag agagattcca tttactgagt tagcaaatat cagaagagaa    44700

gcaaaactgt ggagaaaaag cagtaagatg aattttggac ctgttgaatt tgagatgcct    44760

gggagatagt ctttcaaatg taggtattga ataggcaggt gggtatgtat ttctagagac    44820

taggaggtat gcttgaacag aaaaatagat tttgaaatat gaactattat aaaaatgtaa    44880

cttattataa aaggaaaact aaagtaagag gggtctagac agagagagtt ctgaataaat    44940

ccagtatcaa atgatttgtt agaggaagaa aatcaggtga gtagcatcca gggaggtgtg    45000

gatcacagaa gctaagggca gaaaatattt caatgaacaa ggaacagaaa acaatgcctg    45060

aaacttctaa aagggcaagc aagcaagata attgtttaaa aaatttcgtt tggatttatt    45120

ggtgatgtcg gtcttgttgg tgaagtttgt taaagccatt tggtgggttg tggagtaagg    45180

tgaagaaatg gaactggcaa gtgtagacaa gtatgcaatc ttcgaaagaa atctggccat    45240

aaggaaagga tagatggtgg cacctggaag gggaaataga gtgcaaggag agtttctctt    45300

atgacagtgg tgatatatat attttttgtt tgtttgtttg ttttttgaga cggagtcttg    45360

ctctttcgcc caggctggag tgcagtggcg ctatctcggc tcactgcaag ctccgactcc    45420

cgggttcatg ccattctcct gcctcagcct cccgagtagc taagactaca ggcgcccgcc    45480

accgcgcccg gctaattttt tgtattttta gtagagaaga ggtttcaccg tgttagccag    45540

gatagtctcg atctcctgac ctcgtgatct gcccacctcg gcctcccaaa gtgctgggat    45600

tacaggcgtg agccaccgcg cccggcccac agtggtgata tttttaaggg agagaaggac    45660

tcggtaactg ttactttcta taaagaaacg ggaagtagcc agtagtagaa atgttggtta    45720

attgagaatg aattccttgc aaagtccaaa ggaaaacaca taacacaatt tgagagatta    45780

gctcaaaaca ggggcacttc tttcatttta acaagaagag aaaggcaaag cacagttacg    45840

gatgtaagta gtctagtaga taaagggaaa caaagttcag gctggctgac tttcatcacc    45900

tctaagacgc tgaagtactg agactgtgct tctcagatgg gaaggcataa gcaaaaatgg    45960

ctgaggttat gtgcagaaga gaaagtttga aatagtttta gataatagaa atggagaaag    46020

gaaaatactg cttccctttc gccaacaaaa ggaaattttt ttaagagttc ttactatctg    46080

tagagctagc cgtgagcatg tttattacag cttacatgac atcttagcac cagtctcatc    46140

tgcagggcca agggagggga ccaatccatt tggcttggtg atggaagccc gcactgctag    46200

gtaatcattt ggtaagtttt tggagggcta gaaagatcag agacagagcc aaacagttga    46260

tcacaatgag tcagttgcac ctttcatatg aaaataatat taattttatt gacttaatcc    46320

gtgtactctt tatcatttga taaacattat atatagtgaa caattattga tttgaatgca    46380

aagcatttgt agatactaag ttgttggacc taaaccaatt ttttaaaatc agaatttaat    46440

ttatatttgt tgggagtaaa ttaagttgct caataattat tcgtgtttca agagtatttg    46500

ctcatataat gaactacact tctcatttag gtcttcacag ggatcttcac agcagaaatg    46560

tttctcaaga taattgccat ggatccatat tattactttc aagaaggctg gaatattttt    46620

gatggtttta ttgtgagcct tagtttaatg gaacttggtt tggcaaatgt ggaaggattg    46680

tcagttctcc gatcattccg gctggtaaat taactgggag tgttcataaa atgtactttg    46740

taattaatta gtcttcattc tcatctagta aaaatggcaa gatttcccat cattataata    46800

ttatttgaat acacttctaa aacaaattgg attgccatac caccaaatgg tagtttcttc    46860

ttcatcatag ctttaataaa gttcacttaa atgaatagtc tacacttctc ttcttagtta    46920

ttgaatggaa ggctaataga gaggaggaaa cagggagtca cagataaact cgaatcacaa    46980

ttaaacaaca ccatagtcaa ctctcagtta tctgaggttt gcataactgc gtacaaagct    47040

tccttgggac ctaggatgag ctcccctttc tgccaggaac taaagaatta tggaattgtt    47100

cattgctcac cttgtccccg tagaggaaag agttaagaca ggggatagtg tacaaaggag    47160

aaggataagc aaacagagct ccccatatga ctgctgccac atcagaaaat caccaaatca    47220

ctctttgaaa gagttaactg tactatattt tgttaatttt aaagaaagta tctttctttg    47280

atcttttata aaaactatta gatcttaaaa ttcagagata aaatatcact tgacacattt    47340

ccagtgaaag tttgatatgt tttgttatac tattactttg agttggctct aagttagtga    47400

tttattttca aataacagag gctgtacacg gttactaagg acacgttcct atagatgatt    47460

taccttagta gtgattaggc tgaagacttt ttcatgaaat ctgtttacaa tttccctttc    47520

tgctttcaat gttcaaattt gagttgtaat ccttagaact atatttcctt ccctaatcct    47580

caaagatagt tatgaatcta atttgaatct agaaggatgc aaaaaacaga acaaaaattt    47640

aaaatgataa aacaagtaat atgggcaaga acttaaaaaa atatatttag taaaccttca    47700

tgatagtgtg atgcagttaa gggaaatagg aagcatagta tcactagaat cttacttagt    47760

gtgtcaggct cttttgcata aattattctc tggaataaat taaatacttt ggtgcatgta    47820

tttactcctt tgggtcactt tgatgccatt aaataatgca ctactttcag cctgacattt    47880

actgaagcat cagaaataaa atgctgctgc tctttaacca taaatggtac ttcagtgaac    47940

tctaaagcta atacaaccaa tatgtcaaac acaatgagaa agacatttac acactacact    48000

gaattaagtc tatgaagata taaaggttaa aaagaagcct agcgttttac ttaagtttaa    48060

gtatttttgt atttgaatat aatatatgtt taaaatatag cctaaagtta cagcaagcta    48120

aagatatagc tagattaaaa caatctaaag acaaagaaat tagttcattt ctgcttccac    48180

tttatgtaat ttaagtgttg atattattct cacctgtgca tttcagcata tttaaagtac    48240

actgaaaact atatctgctt tggcctttta aaaataatga gagttcctac ttctctgaaa    48300

ctggatctct gctaattaac caccattaat ctgaaatatc ttaattcctt aaggagaaac    48360

aaaagtgtat attacatatg cttatgtagg atacttgaaa atttggtgta tcttattaaa    48420

ctgccaattt aaaaactgta taatttaatt atttcattta cagtatggac catttcaaaa    48480

tgaaaaaaag aatgctctat ggtagcaagt cactgctata tttgttagtg atcatttgac    48540

aaataaataa ttcatcattc tataattgag acagttacct gtacatttgc cctgttaata    48600

aaattacaga tttttccctt cctgtgtcca tgtgactaac ctgcacattg tgcacatgta    48660

ccctaaaact taaagtataa taataataaa ataaaataaa aataaaaaat aaaaaaataa    48720

aaataaaata aaattgcaga tttttttaga aatgcagagc attaacactg ttcttgcttt    48780

tatttccagc tccgagtttt caagttggca aaatcttggc caactctaaa tatgctaatt    48840

aagatcattg gcaattctgt gggggctcta ggaaacctca ccttggtatt ggccatcatc    48900

gtcttcattt ttgctgtggt cggcatgcag ctctttggta agagctacaa agaatgtgtc    48960

tgcaagattt ccaatgattg tgaactccca cgctggcaca tgcatgactt tttccactcc    49020

ttcctgatcg tgttccgcgt gctgtgtgga gagtggatag agaccatgtg ggactgtatg    49080

gaggtcgctg gccaaaccat gtgccttact gtcttcatga tggtcatggt gattggaaat    49140

ctagtggtat gtagcaaaaa cattttcctc attttcatta aaagataatg taatcattaa    49200

aaagtgtgtt caactgaaga atattttgta ttttttaaat caaggccact tcctattgtc    49260

tattactcat gactgtaaga gccatgtata gtttagacca ttgtaatcca cacaaaccct    49320

taaactacct tttgaaccaa agttattctt tctttcatta tccttcttgc tacaaggaga    49380

gaaacttttc tgttatttat ctttcagttc ttgtactaga gcatggaagt gttacttaga    49440

acactcattt tatttataag tactagcaat aacacctgaa aacgtttcag atttggtttt    49500

ctacaaattt aaaaactagc aacaatctca gtttattaag agctcatggg gttttcggtg    49560

cctagaaact atggtatgag caagtaacat tgtctctaaa aacattaatt gtcatttctg    49620

cataaaatta accaccccta acaccatata tatttaggat agttagctct tcttgttgca    49680

ttgatccctt ttaccattat gtagtgtctt tctttgtctt tttttaatct ttgttggttt    49740

aaagtctgtt ttatcaaaga ctaggattgc aaaccctgct tttttttttt ctttccattt    49800

gcttggtaaa tattcctcca tccgtttttt ttgtgcctat gtgtgtcttt gcatgtgaga    49860

tgggtcacag cacaccgatg ggtcttgact ctatccaatt tgccagtctg tgtcttttaa    49920

ttggggcatt tagcccattt acatttaagg ttaatattgt tatgtgtgaa tttgaccctg    49980

tcattatgat gctagctggc tattttgctc attagctgct gcggtttttt cataatgttg    50040

atggtcttaa caatttggta tgtttttgca gtggctggta ctggtttttc cttgccatat    50100

ttagtgcttc cttcaggagc tcttgtaagt caggcctggt ggtggcaaaa tctcttggca    50160

tttgcttgtc tgtaaatgat tttatttctc ctttgcttat gaagcttagt ttggctggat    50220

atgaaattct gggttgaaaa ttcttttctt taataatgtt taatattggc tcccactctc    50280

ttctggcttg tagggtttct gccgagagat ctgctgttag tctggtgggc ttccctttgt    50340

gggtaacccg acctttctct ctggctgcca ttaacatttt ttccttcatt tctaccttgg    50400

tgtatctgac aattatgtgt cttggggttg cttttctcaa ggagcttctt tgtggtgttc    50460

tctgtatttc ctgaatttga atgttggcct gtcttgctag gttggggaag ttctcctggt    50520

tatcctgaag agtgttttcc aacttggttc cattctccca gtcactttca ggtacaccaa    50580

tcaaacttag ggttggtctt ttcacatagt cccatgtttc ttggagactt tgttcgttcc    50640

ttttcattct tttttctcta atcttatctt catgctttac aaatttaact caacatggat    50700

taaagactta aatgtaagac ctaaaaccat aaaaacctta gaagaaaacc taggcaatac    50760

cattcaggac attggcatgg gcaaagactt catgactgaa acaccaaaag caatggtaac    50820

aaaagccaaa attgacaaat gggatctaat taaactaaag agcttctgca cagcaaaaga    50880

aactatcatc agagtgaaca ggcaacctac agaatgggag aaaatttttg caatctatcc    50940

atctaatatc cagaatctac aaaaaactta aacaaattta caagaaaaac acaaccctat    51000

caaaaagtgg gtgaaggata tgaacagaca cttctcaaaa gaagacattt atgtggccaa    51060

caaacatatg aataaaagct catcatcact ggtcattaga gaaatgcaaa tcaaaaccac    51120

aatgagatac cacttcacgc cagttagaat ggcgatcatt aaaaagtcag gaaaccacag    51180

atgctggaga ggatgtggag aaataggaat gcttttacat tgttggtggg agtgtaaact    51240

agttcaacca ttgtggaaaa cagtgtggca attcctcaag gatctagaac cagaaatacc    51300

atttgaccca ggaatcccat aactgggtat atacccaaag ggttataaat cattctgcta    51360

taaagatgca tgcacacgta tgcttattgc agcactattc ataatagcaa agatttggaa    51420

ccaacccaaa tgcccatcaa tgatagactg gataaagaaa atgtggcaca tatacaccat    51480

gaaatactat gcagccataa aaaagagtga gttcatgtcc tttgcaggga catggatgaa    51540

gctggaaacc attattctcg gcaaactaac acaggaacag aaaaccaaac actatatgtt    51600

ctcactcata agtgggagtt gaacaatgag aacacatgga cacagggagg ggaacatcac    51660

acactgaggc ctgtcgaggg gtggggggct aggggaggga gagcattagg agaaataact    51720

aatgtagatt acgggttaat ggatgcagca aaccaccatg gcaagtgtat atgtatgtaa    51780

caaatctgca tgttctacac atgtatccca aaacttagag tataataata atttaaaaaa    51840

attaaccata cccaacacta gtgtcctgaa tcttgaaggc atggagaagt tgggaaggca    51900

tgggaagata aatataacaa agtgatataa catgtactca aatagaatta aaaataggaa    51960

gtaactaata tgtgtccaaa aatatgaaaa caaagtgcca tgtgtcaagt ttacaaaatg    52020

taaaccttgc tttacaatag gaaggttgat cagggaagtc tttgtcaaag agtttggacc    52080

taaaatatat ttaactgaga tgtaagattt agcttggtag gaagaaagac catcccaaac    52140

aaggaaacaa ggtacccagt gactgaggga tacaggacag tagactctgt gagaagtatc    52200

aggctcttat gctttaaata tgaagtaatt acaccgagtt gcttaattag aacccaaacc    52260

aatggaatag aaaaatgact accataacaa gtaatttaat gtatatactc ttgccaggct    52320

cagtggctca cgcctgtaat cgcagcattt tgggagactg aagtgggcgt ttcacttgag    52380

gacagtagtt cgcgaccagc ctagtcaaca tggcaaaacc ccatctctac tagaaataca    52440

aaaattagcc aggcgtgatg atgcacacct gtaatcccag ctacttggga agctgaggca    52500

cgagaattgc ttgagcctgg gaggcagagg tggcagtgac ccgagattgt gccattgcat    52560

tccagcctgg gtgaaagagc gagactctgt tgcaaaaaaa aaaaaaaaaa agcatatact    52620

ctttagacat gatttcctct catataaagg taacctccaa gtccccaaag atagagaaag    52680

gggaagggaa aaaggcaaag tattatttta tttttattca ttgccaaatt tcagcctctt    52740

caacattact tttgataatt ctgatctatt tttaaagtaa caagaaacat aaacagtgta    52800

caatctagaa ttataaacag tggcttaaaa caataaacac tgattacttc atagtttctg    52860

tgggtcagga tttggggaat aagttagctg ggtggttctg gtttaggatc agtcatgaag    52920

ttgctgtcga gatgttagct gaggttacag ttatcttgac tggggctgga ggatcagctt    52980

ctaagaaggc tcaatctcat gattattgga aggaggtttc agttcctttt tggcagttag    53040

ttgaaggtct cagtttttct ctgcaggacc ttttccatag gactgttgag tgtccttatg    53100

atatggcagc tggcttcttc cagggaaggt gatgtaagag agaaggcaag gagaaaatcc    53160

tctttatgtt ctactcttga aagtcactct tcaccacttc tgccatattg tattcattag    53220

aagctagtca ctaagaagag ctcaagctac tataatcccc aagacaactt taaaatgttt    53280

gctttcagaa aagtataaga tcacatagaa cagaaagtgc catagggtta catagaacag    53340

aaacaaagaa aagataatat aattatgtta tagatttgat ttcattttct ctgtatgtat    53400

atttggtata tgttggaaga agaaaagaaa acgcagagaa cagaatcctt tatgacaaca    53460

tgaatgatca gacagcaatg gggaattaag aaatataagt ttgggaccag attgggtaga    53520

atttaattta tgaaaaggct gactgtgcat aataaaatgt attttccttt aggcaattca    53580

aagctacaga tgatttttta tcaggaaagt gacagtgaac cagtgatatt tttcagaaat    53640

atacgtagca ggagaatgca gaatagattt aaagaggatg aaactcagcc caccacatgt    53700

tatctattag tttactgaaa ttaacatatc tctctaatgt ataaatgtgc agaaaattga    53760

agttgaaaag agaatttcag gaaatatcaa gtacttatgg ttgacatcag tattaattta    53820

gattgtgatg tatgcataaa aagatatagt ttataaaata atcatttcca tctactgggt    53880

gtaaatttaa tttttgttct tttaagagag aaaaattaaa ggttctcctt tctttttgac    53940

tatcagttaa aataacttct ttgtcttgtg ataacctggg tatgtttctg gagtagctaa    54000

ggtagtcata tatatcatgt ttaccactat taaggaaatg tgcttatata acatttgctt    54060

aagactgaat gaacttgata tactcactcc ttactacaat tcttccttcc tattctcact    54120

ggaaaaatgg gaaaggtgtc ccaaagacaa aatggcataa cttcctttta acacacatga    54180

actatcagat gtggctccac ccaaatagat gtagtagtca caatggatgg gactgccagc    54240

ctagtctaca gacaagacag agctgggacc acaaactact gtttcccaga ccaggatttt    54300

tatgagccat tcttagtttc cagacacgat ggcaagagac ccttcattgg ttgaagatag    54360

gtgctgcaga aaaagaatgt gactttctga aaactgatag ttctagaagc agagaagaca    54420

acttcctctc tccctaagtg aaggtgaggc aatagcacac aggagggatg tgaaggtttt    54480

ggcttcctct cacaagttgg gaatcaggat ggagaaacaa ttaaaatatg taatatgttt    54540

caaccttgaa ttcaaaatgg aaattatggt aacatttcca ttccaagagg ctaatttgag    54600

acacaagaaa gagttgattt catttactga gctagcacat ttgtgaaaca ggattcagga    54660

tttcagtccc tgagtgagct tgctgaactg ttttctttct tttttttttt tttttttttt    54720

tttttgagac ggagtctcgc tctgtcgccc aggctggagt gcagtggcgg gatctcggct    54780

cactgcaagc tccgcctccc gggttcacgc cattctcctg cctcagcctc ccaagtagct    54840

gagactacag gcgcccgcca ctacacccgg ccaatttttt gtatttttag tagagacggg    54900

gtttcaccgt tttagccggg atggtctcga tctcctgacc tcgtgatccg cccgaggcct    54960

cccaaagtgc tgggattaca ggcgtgagcc accgcgcccg gcctgaactg ttttcttaaa    55020

ttgtcatgga tcacaccaaa cacctgtgcc agctgttatg cgcataccct tcggtaacaa    55080

aggaagtcca gaaaaagaga ataacttgac tcacacaaat atttctaggg aaataaggta    55140

aataaaaaga tagtgttgtg gaggataagt tggataatag taagtgataa cagctaaact    55200

ttctcaaagg ttcactatgt gccaagaact gtgctgaaag ccacatgaat tctgtcactg    55260

aatcctttca acaaccttgt aagctgggca ctagaaaaac gattacattt attttataga    55320

tgaggaaact gaggctcaga ttggttatgc tacttagtag gtaacagaaa atcgattctt    55380

acctagcact cgaattctaa aatatgtgct cctctatgtc aagtaatcta tagaactaag    55440

ataaacatgc tgatgaaagt tagtgtctag tgggtattaa taaacgcggt ttcaaaactg    55500

tgtcaccacg ggtagattgg ctgctttaaa aaaaataaaa acttcaatgg atttatgaga    55560

aagaaaagtc atatgttcca gggatattta tttattttcc tgacagtgga atagcattga    55620

attgagttat caattcataa aagatcagag aaacaattcg aaaattaata gtaaacccta    55680

ttatactgac taaatatggt agcagttcaa agaaaggaag tatcggtaag agtaaacatg    55740

gaatactgtt tcctcactta ttctgcaaac atcacaatta ggagaaaaga ccttgtagtt    55800

agactttcaa aaaaaaaaaa gcttctctac ttattaactg tggtcttgga caagtcatgt    55860

aagttgtgca gaagcatttt catctgtaaa atagtaataa ttcctgcctt atagagttgt    55920

gagaaataaa tcacataaac cttgaaaatg ctttgcacaa taactggtat ttactaagag    55980

ctcaactaaa aagctggttt tacttttatt gttattatga tctggtattg atactgctct    56040

aggacttggc tctaaggcat gtttctgacc aaaagatctc ccaatctatc agtaaagctg    56100

tgcttgtttt tttttttttt ttaaagaatc caatataatg tgatagggat gtggatgaga    56160

aatttaacag gacagaatga gaaatgggag caggctatat aaatgtcaca gtaaatgaca    56220

tttgtaaata gagtatttgt ccagtacaga ggcaatataa ttggctcccg ccctggggaa    56280

ggattgatgg atgtgtatca agaaaaattt ccaaatagac aaatgacaga actttaatat    56340

actttaggaa aataagtcta ggaaatagca ccaaaataga taaaataaaa attttacatg    56400

caattttttc ttcctttgtc tgttttttta atccaaataa taagttcaaa agcaaattac    56460

aataaaacat aattttattg gtaaattcca gaggcaaagg agcaggtctg gtcttaatgt    56520

gattatcagg agtcatagta tagagactga cagattgtca gtacactctc aaaatcaaac    56580

gtggtcttca ttggatctta catattttta ctttaaaaaa aatcaccatt ggttagacta    56640

acttacaact aattagacaa aggtgctgta agcctcatta gcatgataga agcatgagaa    56700

tatagcaaga atgtagaatc ctttttattg aagttttact taaaaatttt cctaagattc    56760

tacttttgta ctacagtttg agcatcccta atctgaaaat ttgaaatcca aaatgctcgg    56820

aagttcaaag cttttgagca ccaacctgat actacaagag gaaaattcac atctggcctc    56880

ctgtaatgaa tcgcagttaa accacagtca aaatgttgtt tcctgaacta aattattaaa    56940

aatattgtat aatattacct tcaggctatg tgtatgtgta tgaaacttaa atgaatttta    57000

tgtttacaca tgtgtctcat tctcaagact tgtcattatg tacatgcaaa tattttaaaa    57060

tctaaaatcc aaaacacttc tggccccaag catttcaaat aagggatatg caacttgtat    57120

ttactttgtg catttgcccc cctttactgc tatatctttc ttttgttctg tatgttatgt    57180

gtgcttaaat aatcaggaat tcattgatat tgtcaatcaa atcctgaaaa aaaattatat    57240

gactcagtct tgtacccctg agaatgtctg atttcttcgt aagttgtctt tttttttttt    57300

tccacaatag tgagtttaat gtcatgaatc ttttcactca ttcatactgg tggagcctat    57360

ttttaaagac ccaatttgca gactgattac tgtccttatt catggcaata cttcaactcc    57420

acaatcttta attcaacaat aacatcataa ttattgtata ataaccattt tatagtattt    57480

ctcactattg tataattata gtagccataa ttgtcttaat aaaaattggg acttttcatc    57540

cagcaataaa tacgtttttg tctgatttgt ccagttatct aggtacaaaa aatggtacaa    57600

aggcacaaaa ataaaatcat atttaaatat attgggataa ttgttgattt taggaataaa    57660

ttatcagtgt ttccggaaat ccaaattaca tagtcaaaat agcatctgta ttaggccatt    57720

cttgcattgt tacagataaa tacctgagac tgggtaattt ataaagaaaa gagatttaat    57780

tagctcatgg ttctgcagtg agcttggtgc tggcatctgc ttggcttctg gtgaagtctc    57840

aaagagcttt caatcatggc agaaggcaaa gtggagcaag catttcacat gatgaaagca    57900

ggaacaagca agagagaatg tgggcaggag gcactacaaa cttttaaata acaacatctc    57960

atgagaactc actaacatga ggacagcacc aaggcatgag ggatctgacc ccatcatcca    58020

aacacctacc accaggcccc acgtctagtg ctggggatta caattccaca tgagacttgg    58080

gagggggcaa atgtccaaaa tatatcagca tcccaaataa aagggttttt tttgtacagt    58140

tgtctatatt tatcttttgg aactgagctt aatagaaatg tttcatttag caatgatttc    58200

agtattttct gcaatgacta aaaagcaaat agtgataata gtattatttt atattgacca    58260

agcattttta tttcattcac tttttttcag aatagtgtat catgaattag cagaaatgca    58320

tgttagaata aaataaggtg tcaagaacaa tcttagaaaa ctaatgatgg aaagcaattg    58380

aagcaataga atgttttgat cacctgtttt tcctgctgtg tttcaggttc tgaacctctt    58440

cttggccttg cttttgagtt ccttcagttc tgacaatctt gctgccactg atgatgataa    58500

cgaaatgaat aatctccaga ttgctgtggg aaggatgcag aaaggaatcg attttgttaa    58560

aagaaaaata cgtgaattta ttcagaaagc ctttgttagg aagcagaaag ctttagatga    58620

aattaaaccg cttgaagatc taaataataa aaaagacagc tgtatttcca accataccac    58680

catagaaata ggcaaagacc tcaattatct caaagacgga aatggaacta ctagtggcat    58740

aggcagcagt gtagaaaaat atgtcgtgga tgaaagtgat tacatgtcat ttataaacaa    58800

ccctagcctc actgtgacag taccaattgc tgttggagaa tctgactttg aaaatttaaa    58860

tactgaagaa ttcagcagcg agtcagatat ggaggaaagc aaagaggtaa aaatgtttaa    58920

ataaggagat attttggtgt tatataattc tgttgtttaa aattatcagg tgtttttaaa    58980

ttgcgtgttt ccttcctgtt aagaaaatag aaaatatctg tctagcaata tattttccat    59040

ggaaaagttg gtaataaata aattaatgat agattaaaat atagctagat taacaatatg    59100

ctgacttatg tttccaatac tgacattttg aattcttgac agtattcttg atatgaattt    59160

tttcagtatt tataaataat tttaaatttc tcaaaatgcc tcaatttctc cactttcttc    59220

cttgtaattt gcccacaaca gtgttttttg tacgtactgg aaaaatatct gatgagaggg    59280

tagttgcaat tctcatcttg ctatgttctt agttcttaat tcttacgaaa tacgtcataa    59340

aatagtattg tattttgttt gcacagacat atttactcaa ggaagatctg attgggatct    59400

tggcttgata tttatgtata gtttatcttt cctgaagtca gtcagttttt ttgaagagaa    59460

ggtattgatg aggaatcaca ctaaaaacat atttaaccct actgagctca gtgttcactg    59520

tttaaagaaa caaaaatcct taatacatta tagaatgtaa aattctgaat ttaccaactc    59580

agtaagtcct ggtaacttaa tgtattcttt gatttacaag aagggtatga gcaacagaat    59640

atattttttg ttttgtttgc tattaacctg ttgctcaata agtacagagt tggaggtaaa    59700

gagaggaatt taaaaccttg atatttaatt gtttatacaa aaatgaagac aagatttcca    59760

gtaattaaag tttgcactaa ctaacaaaaa taacaaggaa aaacaaagat tcgttccttc    59820

ctcatacgaa ctgtttggcg aggaagataa aagcttctat tcctgatgtc gggaaagaaa    59880

gaatgacgac atgggggagt gtgggcactg aaaggtaaaa tttaagtagc acaacatgat    59940

catgataatt aacaatcagc caaaattatg agggaaaata tagttataaa aaaagaacaa    60000

agatgggtgg atcacgaggt caggagttcg agaccagcgt ggccaacatg gtgaaaccct    60060

gtctctacta gagattcaaa aaaattagcc aggcgtggtg gtgcgtgcct gtaatcccag    60120

ctactcggga ggctgaggca agagaatcgc ttgaacccag gaggcagaga ttgcagtgag    60180

ccgagatcac cccattgcac tccagcctgg gcaacaggat gaaactctgt ctcaaaaaaa    60240

aaaaaaaaga actagctatt tcagacactt tttctgtatt tatttgataa aattactaaa    60300

gagtatgtta ttttccattt tttcttgttt gtaagttacg tagtattgct gttagtgatt    60360

aggtagaagt agatgtttaa tgggaaattc agacaatctt tgaatatagg aaggtataaa    60420

taacagggac ataggtatca gtttcacaag aaataactga tgagattcaa gggaaaagta    60480

ataaaacctt ctgtcctggg gcaaagaatt actttaattg gttgaactta aatttttact    60540

aactagatta ttgtttgaaa gttgaataat atcttaaaat cttattaaca aaattttgaa    60600

caagtgttgt tacaatagtt gggttatgct ggaagggtgg agtggcccaa tttcatatac    60660

agtgtactgc tcttatagaa gctgaagtcg gcatttataa aatagaattc ggtcatttga    60720

attttgatgt atattcccct ctcattattt tgaaattatg cctaatggtg aatatttccc    60780

taatagtaaa aaaagtcaat ttttattttc acacatgttt agttttaggc tgtcatataa    60840

actaagaatg aattatacag tatcaaacgt tgaagccatt ggctagttta atcttttagc    60900

taagtttcag tatcttttga ggaatgttta acttgacatc cagtcttctt aactttaaga    60960

gattttacag ccgtgggttt tccaaaagag cgtgtatttt gccttaactt aagccattat    61020

gtctgaagta agagggaagt ccagtgatgt ggggtttaga gtagggacat ctcttgtttc    61080

tcttgttatc attaagcttt ttgatttgtt ttcccattaa gttagctctg agttaaatac    61140

tctaaaataa tatttgtgaa ttcagtattt cagaattgga ggaagagaac tgacctgcca    61200

ggtggaagca gacaggatta ttttattgct tgagttgtgg agtccttcca ataccttccc    61260

agcatagaga ctgttacttc agtgttaaca ttatttggag gggtttttaa ttctggcttt    61320

atatcaaact ttctagacat aaatttataa aataataaat gatgagggtt atcgccgtga    61380

aagaggttat gtgtaggttt tgatctttca gaattttacc tggtagctct acactaaaaa    61440

actagagaat taaaacaatt attgaagaat ttcagacact cgcatttgaa atagcatttc    61500

ttgcctgcct tctagtcatt tttgtctggt catttttcta actgggggac aggattacat    61560

tgttaaatat cacaaagtag taagaaacat catgaggctt attaccaatc ctttctaaat    61620

taatttttta attaaagaaa aaatgaggct tttttactgg aatgtctaaa tgaatttttt    61680

tataaggcag actgagtgga ctcagaggtt ttttaggtgt tcacagtaag tcctctgcaa    61740

tgtctttgct aaatttgtat gattcttcag tagttttctg tagattctct agagtaggcc    61800

atttaaaatc atgtcataat cccctatgct ttaattttaa tgttatttcg attatattaa    61860

tgtaattcct tttgtgattt tgaatgattg ttttttcttt tagagtattt aataatgtgg    61920

aagccatgct tgaatgacta tttttcgaag tgaaatttag tagtgcgata tggtgacctt    61980

caccgcttac cattcttact tctcacagga gtaaaatcaa gctggagcca tcaagaatgc    62040

agctctggtg ttttttaacc agccagaggc tcgtgccacc acttttaccc aggttaccca    62100

agcaagttgt acatctataa atataatcag tttctaaatg acttttgact ggcctgcatg    62160

ttactcagct acgttccttg cccttccatt ggcagtaaaa taaaaacatg cacagctgct    62220

attatgctga gtcatacaaa gcatggtcag gcaagtctga caaccctaac ttaaaaaaaa    62280

gtgatttagc tgctaatttt cttacataga ttttaataga aattttattc aatgaaaagt    62340

aaaagtgcat gcctttatgg attatttaat ttccttttaa tgttacagag ttttgaacat    62400

attaggagcc caaaggagaa atgtaggtgc tctttgaaaa cttgcaaaaa tgctttttat    62460

cctctgtctt taaaaaaaag atagcccagt tactgtactt aagtcttgac agttttttat    62520

ttagtgtaat gtttttctga agggtaatct tcaaattaaa gcaatccctt attcatatgc    62580

aaacttccca aaggatgttt taatgtgata ataatgtaaa tgaataggaa tgtctgtgtt    62640

tcagttgcta gcagcatggg tataatattt atctgcttca ttttagggaa aatggcactg    62700

ctttatttag gagttgacca acagtatttt gtatttagaa tataatttct ttggaaagtc    62760

tgtttatatt tacccttaaa actcttagac tgaaagaaaa ggaaatcatg tcttttgtat    62820

accaaataat aataataata gtgataatga gagacttata gatggtatgc tccttctaaa    62880

aatagattta gagtccatct tcttcatttt cttggctcct ctgtgctttc tctcccctct    62940

attttattga gacctgctgg aaaactttct cccgaagaat attatttaaa tttatcatga    63000

tccacaaact cctgtatagg aaaagaatca gaaactcttg ctcctagggt gtttttaaaa    63060

tgaagagact tccctatcat gtgacaatag caataaacgt aacatcattc tatgggatcc    63120

attagtcgac cttcatttct taatgttgaa atcacagttt tatgcacaaa tatttaacca    63180

aaatgcctaa acccaattta atcattttta agaaatgtta attattttgt cacttagata    63240

cagtttcctc tccttttgcc aataaaacta taaaacagca ctaatataaa agtgtagttg    63300

gctatttgga agaagcaata atcatgccat tcctggagca ttcttttata ctttggaaca    63360

aaatattcca tcactggctc tccagattca tgagctataa tgcctcatat attggaggaa    63420

tgggatgtaa aatgggatcc aagatgcgta attgtttaca gttaaacaca gatgcgcata    63480

tacacaggga ctacagataa ttactttttc ctattatgta ttaattcttc agaaaagcat    63540

gagatttagg cactttcgga taatagcttg tttctcggaa agaggcaagg gtagtttcct    63600

tattctctga gtatcccatt ttgccaattt cctgtttaga aagatacttg aggcatatta    63660

tccatcaacg tatctagggg attcagctgg agtaaaggtg gtagaataga agctaagaag    63720

gaactggttc gtttattttc aatcctcaca ttatggcaat ttttgatttc cttgtaaaag    63780

tctatgattc tccctcagga aacattgtcc acttcctaaa aaaatatact aatttctaat    63840

acaggggttt ggaaagggga caaaaatgtg cagggaaggt ttgcgtaagc aatggtggaa    63900

tgggttcaac agacacctgt ctatgacttt atcctggaga atgtgtagtc ctcatgggaa    63960

agttttccag tgggatagtg attaagatgg aaaaaaatgc ccaaaatatc tttaatataa    64020

gaacaaaatg ggccaaacac gtgtctttgg gtcactggta atctactgag cagtaggaca    64080

tcatgacata agagttcctt ttgccatccg aagaaaaata tttaaaatcc tattatttgt    64140

ggttttaaaa atgttataat gtattcatta taaacactaa aatgactttc tggataatat    64200

agtatactgt gagtaattat tttgatttta ccatattctt ttttagttct cagaaaccaa    64260

aattgtcaga tatgggatac ttgatttaat ctgtatttga agttttctct tttttaagtg    64320

ccaatttttt aattaaatta aattaaaatc tctctctctt ttcccaaatt atatacaata    64380

tctactaatt atgttttctt cgaaatgtat cttagcttca taatgagaag tgagtgtgcc    64440

catgaaaaat ttaataggaa gttatgtttt ctcttccatt ttctgttgtg attcattatt    64500

tttgaaaata atttactttc atttgctcac atttgctgtc taaagaaaaa ctattcatct    64560

ggcacattca tatttagtag tattattaaa gcagaaagca taagttggaa gtataatatc    64620

taaaaataca aaatgaagta ttgtaccttg atgtttatta gatcattaag caaaatatga    64680

ttctgccctg cttaaatcat ttgattataa ttatccagca tataaaagaa tcacagtaga    64740

ttttcaatag gaagagtcct ataatattag gtatccacca aaaacattgt tcaagtaata    64800

tttccacctg aaagtaaatg attgccaatg ctttttttca gagcatataa aattggctat    64860

tcctatttga tctcgttatt gtcctggcat ccttattttg ttaaatttta actaggcaag    64920

ggctatgcta caaacatcag ttagtccgct agtttcctga taaataagta caggtaatta    64980

aaaagtgaac ctaaatatcc aaattatacc aaagggacat atatagaact ttttaaactg    65040

gatctgcttc tagccagttc atattttggt cacttactaa tgtagtattt caccataaat    65100

tatgcctaga ttggagcatt tacaggcact ctttatctga aaattcttaa gtgcatgagt    65160

tgtaacagtt tcacatagtg atcatctcac tgttctaatt ggtgactatg tactacagtt    65220

aggttgatcg taattatgac cttaaatgaa gctgaatatt tttatattcc taatttgatt    65280

aattttattt tatgggcttt tacacatttt aactgcttta gtcaacatat tttataatat    65340

tatgacattt gcctagaatg taattttaag aaagtcattt aattgatgtt atcaagaagg    65400

gttttataaa tcagaatttc ctgcctatgt ttcaagatca ttgcttaaag aaaacttttt    65460

gttcatgtaa tattccaatg tgtatttagc tttactctac attaaaatat gttaacaact    65520

atgaatataa cttgaattaa tactaaagtt catggttttg aaacatggaa atcaacaata    65580

tcataagcac tatcttgaac ctacaatatt tgattacata tctagtctac taaatgtttt    65640

aaattgataa acattgggtt tacttttgaa tcatcaaaaa gattctttag agaagcttgg    65700

cagaatgggg tgcagaagat ctggaatcca accactgatt cgctataact tttcacaaga    65760

cgataaaact cacatttcct tctctaaata aatactggat tggctgacat taaggatcaa    65820

tgtgctgcct agattctttg ttatttgtaa atcaagtacc acaagtggaa aagtattcaa    65880

gtaacacatg tgacagatcc tgtgctgctc cgcttcagaa gacagtgggg aaggataaga    65940

ttgcattcct taaagaggcc ccattcatca ctggagctat agatccttgt atacagagtg    66000

aaaagaggga aaacactgtc aaaatgattt agtaatagtt ttcctgactc cacagttaaa    66060

ctacagttca cctcatacac tcacattagg tccgaataat tggcagactg gttttaagac    66120

aatactccta gttctaagag ttgttcgtca ttgcccacac aattcagaat cttaaaagat    66180

ttgtgttact ctgcaattaa gagaaaatat tgtgtgtatt cttttgaatg tgaaagtaaa    66240

tatcagatag gaagtgttag tagttagtgg ttggataaaa gagtcctcgc actggtcatt    66300

cattcattta cccaaaattt attaaacaca aacattggtg ctagagatac aagggtgacg    66360

aaaacatgat ctttcctcca aaaaattaag tctgatgaga tgcattttct agaaacacaa    66420

aatacttttg aactgaacct tggaaaaagt aaaaacttga cctttcaata gataaatatt    66480

tggctttagg aaaaaggtat cttaattcta catcagaact aaggtagtgc actaaaatga    66540

aagggagcaa tgttaattct tctactttta atgtgattta aataagagaa aatacaggaa    66600

tgtcttttat aatttgaaat tccagagaaa atgaataaaa aagcaattaa aaaaaacacc    66660

tcaacatgct tctcattttc agccaagtac agcaaactct gtttgatatt ctctgatttt    66720

aaccttggat caaactattt ggcaaattgc taatttgaac aggctattga aaacagacag    66780

tgtatctagc aattcattca ttcattcaat acttaatgaa cagcattttg gcaattcaaa    66840

gcctgttcct tgtattgaac tatattggtg tattatccat atggcctaga gtacatgtgt    66900

attattcata ttatccatat tggtgtatta tccatagggc ctagagtacg tggcttctgc    66960

ccccaaatgt cttacaagca tgttaaagta cccaaaatcc atccaactga aataatttga    67020

cccatacatt atcaaggttc aagatgtgtg ataagccatg aaaaggttgg tgaatagcct    67080

agggtgcata tggtgagtga agatggatgg aagaaattag gagtccagat ttattgggga    67140

gactttatga aagcaaggaa tcatgattgt tgcaaaatag acagtgaaga aagaaatggt    67200

gtggtggtga aagtcttccc aaagtcattt aaagtattgg caacccagat acttggcagc    67260

aggagtgata attgatgtta caggaatcct atgtaaactt ttgcacattt taatgaagat    67320

tttctataat atgctgtctg gtgacttctc ccaatcactg tcaagggcta gacttcatta    67380

ttttaagatg tctttcattc atttattcac tcactcattc ttttttttaa gcaaaattta    67440

ttaagacctg taacatactt agcactgatg taagctctga tacagtcatt cagtaatgtc    67500

agcctgagca tttgcagaac cctgaatatg gatcctcatt tttcccttgg ggtcacccga    67560

agtcttaccc cgttctgtgt ttacagtgtg aaccttattc ttataaggaa tattttttgt    67620

ttcttattgt ggattgtctg tacttccatc agatgtgact cagcttcagt ttttctgatt    67680

acctgtgtta ttttccaaca tgttgcaagt gataagatca gtattatcag gtccctaata    67740

gcataacagg ttcgtgtgaa ttagatatat taaaatgaga agatttttaa gtcatttttt    67800

agtcaattac gtgtatagaa acatagttat acttatctca gaaagattcc aattcaaagg    67860

ataggaaatt agaaaaacat gtaatgtttc ttctgagaac aaatatattc aaattttaat    67920

gacaaagata ttaggattat ttttctagta atttgatata cctgataaat taaaataaga    67980

aatcatcaac cttcaagcac cttataatat ataatctttg atttaacttt tttggacaaa    68040

ttaaaaaata attctctaac tcaaagcagg cagaagtatc taatatttat gcttccatca    68100

ttagtatttt taaagtacaa gagacaaaag catttttaat ctcatgtata tcatacatca    68160

atatttttta agtcatcagc atcactatgc taaggaaata ttttatataa agaaaattat    68220

tttcataaaa taaagaaacc atctttctag agaaaatcca cataatccta tgcccaaata    68280

taaatataac atttacagta ctgactacag catccatctt attctagttt aacatacttc    68340

agtgtgcatt ttatcatgtg cttacctcat cctttttata aagtatctct tatcagctca    68400

accatttcct aatgttatgc actaatggta ataacattgt aacaggtccg agaatgctgt    68460

ggcccaaact actctgattc ctgtgtggca ctcacacctg gccctgcatc atttctagag    68520

cattttaaga ccaggttaaa gactgggatc ccttcatgta tgctgatccc aagaatggac    68580

cgacctggct aaagtttatt gcatttcaag atataaaaca acttctatta tatttttctt    68640

ttggtgatat ttgatttaac ctaaaggaaa acaaaagaac aactaaatat tcatttctgc    68700

ctgtactaac agggcaggta agagtgccag agtaacaagt agtttccaaa tgcacaatga    68760

aacacaggag tgcattggcc aaagagaatg caaaatatca gctcttgcta tatagctaac    68820

aatgtgctgc tctttttgga attagaaaat tatagaatat atttaataac aatctggtat    68880

atgttttcat gtcaatgaaa agtggataaa tttagatggt tgctgtttat gtgcatttga    68940

tcaaatcttt tctgaatttg acatgaaaat acacttgtgc agctttcatt ggttgggtca    69000

caattttaga ataaaacaaa ctatttgaaa accatttgca aactaatgta caaaagcaag    69060

atcgcagatg attatatgac tctggcagct tacataagct ttctgcagga ttttctttca    69120

gaatctctat acataggctc aaacagaagt tatttccgtt gttagcacca tattttaaag    69180

aaaaaaaata ctatggtgtt gtatctaatc ttgtgacccc tgacctttac caaagcggat    69240

tggcattatg tttaagttct taaattacag atcaagaaaa tgcatacaga agatgggggg    69300

ggggcacacc taattaattt ttatatttag attaaagaaa ataattaaat gtgttttttt    69360

gtgggattga ttttcagaag ctaaatgcaa ctagttcatc tgaaggcagc acggttgata    69420

ttggagctcc cgccgaggga gaacagcctg aggttgaacc tgaggaatcc cttgaacctg    69480

aagcctgttt tacagaaggt aagcaaaaca ataacatatg tggtcttgag tatcctcttt    69540

tctacccatt ttttcctatt tatttaaatg tctgtttatt tgtctaccat ctattatcta    69600

tctatctgta tctatctatc tatctatcta tctagtaatc atctatacct atccaacaac    69660

tgtacattta tttgtttttt tttgcatttg ctgtttgaaa aaaaatgcaa ctttttaaaa    69720

ggcaaagttt aatttatgta attagatatt ttcattttta tgaatcattt ttaactctaa    69780

gaaattatta actggctttt ctgtggcctt ctaaaatatc ttacaggaga gaaagccaaa    69840

tcacacacat ctctctttag tttaaaaatt caataaataa gaaagtgaga gaagtaattt    69900

attatgtact attttgtgat attataatgg gtaataattg ataagtgtac atttaaattt    69960

gtccttgact gaaacagctc ctatttcagt caaggtcaaa tattttttat tatttctgaa    70020

aaaagataga tcataaaaat gccaaaatat actatgagtc atatgatatg gggcaatatg    70080

tcactggagt aatcgcaaaa ggattttctg aagaaagcta aaattatgta atttgaggta    70140

tggatcagtt atatattgta atagcaatgc tgtgtatcaa accaccaaaa accctgggct    70200

ctaagctgct tttctagttt tgactcctat ttccttctgt gtaactcaca gactttcttg    70260

tcactaagtt ttacttgtat cattgtttct ctattcttac agcttcattt tctacatatg    70320

tctcttatat atccttcaag atctagtctc aaatccattt cctccataaa gctcagaaat    70380

taaagtttac cagaaaactc tcataatact ttgttttgtg ataattgttg ctttccataa    70440

ctatagaatt gtagacaaat tgccccaact taaaatgtac attctttgag gacaaggcta    70500

tgttttacat gttatagtat tacaatttgt tctatgcaat tttttgacaa tagtagatac    70560

tcaataagta tttgttgaag agcctttgat ctagcaatcc agaaattata caaaggtgtt    70620

tattggattg ttattgataa tggccagatt taaagcaaac gaagtattca ataatggtgg    70680

aattgggctg ggcacagtgg ctcacacctg taatcccagc actttgggag gccgaggcag    70740

gcggatcact tgaggtcagg agttcaagac cagccaggca aacatggtaa gaccccatct    70800

ctaccgggcg tagtggtatg tgcctgtaat accagctact tgggaggctg aggcaggaga    70860

atcgcttgaa cctgggagac agaggctgca gtgcatgagc cgaggtcagg ccactgcact    70920

ccagcccgga caatagagtg agactccctc tcaaaaaaaa aaaaaaaagg tggaatagtt    70980

atattaatta tagtaatcat atttagagaa atattatgaa atctttcaca aatttattta    71040

cttataataa agatgggaaa tagttatacc attaagtgaa ctaatcagaa ttcaaatatg    71100

taaagtgtcc atatagagtg gaattacact cataggataa ggacaggatg gaaataccaa    71160

cttttggtaa gtttattttc tttttggttc ttctattttt tatatattgt gtttttgtaa    71220

tgtaatccat tatagtagtg ctataaacat aaaaataaat atttattaaa caaatgatta    71280

aaaagccata tagatgattt taagatagct tttgtaagcg gaagctatct taaaaattaa    71340

tgttatttac aatgtattat caggtaataa tgtaaatgaa tctcccacca acacaaatat    71400

acctaatcaa agagtaattt tttgtcttca tttttttccc acatatttta gactgtgtac    71460

ggaagttcaa gtgttgtcag ataagcatag aagaaggcaa agggaaactc tggtggaatt    71520

tgaggaaaac atgctataag atagtggagc acaattggtt cgaaaccttc attgtcttca    71580

tgattctgct gagcagtggg gctctggtag gtgatgcatg atccactcct tcacctttca    71640

tctgaaatct tttccctttc ccttcaatca actcatatta cccactttta aattaaggtg    71700

tttgtaagaa tgagaagaaa tatgtgtgac gtgtttagca catatgagag gcttagtaaa    71760

tagcaatttt tgtcactctg tctggagtag ccctcgggtg gaaccaaact cagatcatta    71820

tggtttctta taatgtttaa agaaggatct ttctgacttt cagtcatcag aggcagttct    71880

tattaagact ggttatgtag acatgatgta ggattatcag ctaaatatca gactgaagca    71940

cgatatttcc ctgacccctt tgcaggtgag aactagagtg catgggtgcc ggtaggagcg    72000

aactccactc actcactgct ccacccctca caggaggggg agcgcaggtg actgggtgca    72060

ggagccaagg caaatgcatt tgggcactgc aagagtgaac tccataccgg ccccacagga    72120

gcgtctaggg gagggtgcct gcgatccttg aagccctaga ggaagtgtta cagtgccctt    72180

ttagctttgc catccatgga tggcttaaat gttaacagtt cagtggaggg tcagagtgac    72240

agccttttgc acccacactt gtggtaccca agttcatgtc cggcgtccag gaggaatgag    72300

tttgtacaaa tgacttgaag atggtaaata caggggattt tattgccagc gaaagtggct    72360

ctcagaggga agaggagctg aaaggagatg gagcaggaag gtaatcttcc cctggagtct    72420

ggccatcccc agccagactc ctctccgaag ctatgctgtc aagctgtccc tctgatgtca    72480

agctacttct ctctaatgtc caactgtagt ctctgatgtc cagctgttcc tcctgtctgc    72540

ctgctgagtt ctgggcttta tataggcaca ggatgggggc agggtgcacc atgggtggtt    72600

ttggaaaagg caacatttaa gtgagaaaac agggatgtat attctcactt tgggccacgg    72660

ttccaggctt gagggtggag ccctcgccag gtacccgtcc tcttctgccc agaatttctc    72720

tgcctcttgt tcctgtcaaa attgcttaac ataaactcca tgctgcaggg gactcctctg    72780

tcttcttcac actgattcgc tattgccaac cacagtgaat gataagaagt agactcactt    72840

aattactgac tagcaaaaaa atgatggcat tacaaactta tgtctgattt cattcaatga    72900

aatgatcaac tggatcaaaa tattaatata atgaaaatga tatgacctat tttcttaatt    72960

ggtgatacaa atgtggttgc attcctttta ctgtttcaat ttaattaata actagagtgt    73020

ttggtgagtt gatttcatta ggagaattac tgcattggat ctggaggcct ctaaggcgaa    73080

ttctgatttg actaagaatc ctgtgtcctg ccatatactc agtttaaaga ggatcagcca    73140

tgctttattt tctttacctt tattattatt attattattt tttagacagt cttgctgttg    73200

cccaggctgg agtgcagtgg tgtgatctcg actcactgca gcctccatct cttgggttca    73260

tgccattctt gtgccttaac ctcgcaagta gctgggatta caggtgtgag ctaccacacc    73320

tggctaattt ttgtactttt agtaatagag actgggtttt gccatcttgg ccaggctggt    73380

ctcgaactcc tggcctcaag agatctgccc gtcttggcct cttaaagtgc tggaacgacg    73440

ggcgtgaacc accgcacctt gccagacatg ctttctaaag ccaagtagag agagaactat    73500

gaagtctcat tagtgactag tacctttgct gtaggagctc tttgttctca gttacaccca    73560

gtcagtgctc accaaattgc acaacgtgct ggcacagtgg ctggctcctc aggggtttac    73620

agcttcagct ataagcaaag cccagaaacc tttaggtcct tgtatggagc tctggttaca    73680

agccctgatt cttgttatct aaaaaagaaa atgttccttt gtctttaatc caggctgcca    73740

ggttttcctg ataatttttc cgataagaag atcaagttag ataaatagtc ttttcattct    73800

ggaagcctca ggagttcctg caaatgagtt acccactctt tcccaagggc tctggaaaat    73860

tctgtcaaag ggaatttcca aacgtacacc cacccgcctc cacacacaca cagacacaca    73920

gagagaggga gagagacaag aaagtgagca atgacaatcc tttccttttt ctgtaggctg    73980

agggacctcc ctgctttata tctgcattac tagaggatgc attccattga gtctgcactg    74040

aatgagacca atctactccc aggcgttcca ctgcctcctg atgtagagag aagcagctgg    74100

cagtctctca aaaattttaa gctctttggg ggtacactga gaccaaaatt taaaaattac    74160

tgaaaccctt ggttgactga aatgcccagt cagcagtcat ttatgatcag ataatgataa    74220

agtaaaattc agccatggga aacattaaac cttccagcct taggcacctg ataagagctt    74280

gcatcgtttc cttttttaag aaatcatcaa ttagagactg tttctgatca taaaatttaa    74340

tagaattttt tgacttacag gcctttgaag atatatacat tgagcagcga aaaaccatta    74400

agaccatgtt agaatatgct gacaaggttt tcacttacat attcattctg gaaatgctgc    74460

taaagtgggt tgcatatggt tttcaagtgt attttaccaa tgcctggtgc tggctagact    74520

tcctgattgt tgatgtgagt atgctgcact ttgctgcttt attcattggc atatatgtaa    74580

tagttctagc aatggtgcct gacacagtgt aggcactcag taacactgta tcagcccaaa    74640

tataaattat gtttctcatt tcacagtgag aggatgcctc aaaacatttt ttaccaattt    74700

aaatacatat acattcatag ataaaaatca aatgccatca tactatactt attcacttaa    74760

tttcaaatta atatttaaaa tctcaagtta tgcaaaataa aatatgaatt tagaaatttt    74820

gctttttgca cactcacatt tcgcaaaata acttgtattt aaatttttca caggcatctt    74880

tgacattagt atgtttgtca tcactaaagc ctgttgagtt taggtcacac agatgaatca    74940

ttaattacaa agaaatttga aagtccaaaa agcaagagac accacttgat ttgtatgata    75000

tagaagcaaa ttggctattg accaagtagc caaagatttt attaaaccac attggtgttg    75060

aaataaaata agatagagta ctaaaatatg agggttttta tataattgaa tatgaggcaa    75120

atctaccatt aaatgtacta ctactattaa atgtataaag gttacatgca gaattacatt    75180

aacagtctct ggcaataaag gaagacaata aataatattt agaactacat aagtgtggac    75240

attacaaaca atagaaaatg caccaaaact ataaccattc ttttatttgt ataatgggat    75300

tatgcatgat actatttctt ttctctattt tctgtatgta cttatcatag gttggtaaat    75360

ccataataaa aatatctgat acttgatata tctatgttag gataaaagta tcaagtcagc    75420

actgcttgaa tataaggaaa ctcttcagag aaatctagtt gtcctgcagc taatgatcat    75480

attacccaaa gtactctgat atttaccttt ttagatttaa gaaaactatt atgatagtat    75540

atgaaactga tcaacacttt gccttaaatc aaatatgctt attgctcatc tatttcatta    75600

tgaaagatac aaatataaat aagtcatttt tctagtcctg cagtagctta cagttgaaaa    75660

gtgaggacag ctgcgtacac agtaagtcga cacctgtatt acaagtgcca cctctttact    75720

tgaggaagga ggaaaggctt caatagggaa gtggagtgtg agctggagct tgagagatgt    75780

gaatgctagc aggcacagct gagggaggaa cacggattcg ttaaaacgtt ggtgcatgac    75840

atgcagggcg ggttccagaa acaagtagat agggtgaggt aagcctttgt aatgggatga    75900

taaggtaaga aagataagtt agaaaagatc tgaagaacct gagatgccat ccaaggaaat    75960

ttggacttat tatttaatac agaggaagct attgaagaat tacatatagg gaagtgacaa    76020

gacctgcttg ttcttttagt gagggaagtt aggtggaggt gagaatgacg gaatagaaag    76080

gagatttatt tagagatcaa aacaccaatt aggagattgc tgcaatgtcc cagaaagaga    76140

aggcctatat gtatcttctt ttccacattt agctacacaa gtcacataaa actgaatatt    76200

ttacaacttc ttttcagcca gtaaatacta ccccattcaa aatattttcc tctgtctaac    76260

ttttatcttt catcctttaa cttatgctta tctctttttg gttctgtctt cagagaaggt    76320

aaagtactac aggtccttat atcttaaata cagaaaagct tcacaactca tgataattca    76380

gtaactattt ttcaattatc tgttaaaaag ggacttacaa agcctaagag tttggatttt    76440

aagggaacta tatgaactat gtaagacata attttacaac tcattgtttt ctgtattcaa    76500

gaggcttcac tttcaaattg catgtgcaaa attattttga ataagttgtt ttttgtaaca    76560

actttcaatg tgcttcactt attttcctta aaaaatatat ttttcaaata tattaacacc    76620

atactcttaa aagctgtatt gcatatttat ttttatttat ctgcttttga aattcaggtg    76680

tactttagaa caaaatagct tatataattt taataatttt tctatatgtt ttcaaggaaa    76740

ttggacatgt gtatgtcccc cgaccgtttt tctttttctt tttagctaag actttataat    76800

ttttctcaac tacattagtc aactgtatga ataactaaag acaacattgt tcttgcaatt    76860

tctaatttat cataaaatct caactttttt tattcactaa ttttgtctga cctaattaat    76920

gatattatgc ccttcaaact gaaatttaca aaagtcaaag ctgcttttta gaggcctatt    76980

cctttttaaa tgtgttcatg ctcatattca ccagtggttt gtatagttta cttgtgtatc    77040

aaatgttact ttccatttca gatctgctca atattattag aaatgataca gaaataagtt    77100

ttacagatct gtagaggaag atcacatttc tctctctttt ttttctttac ttttaatttt    77160

ttaaaaacat ttcctaccaa gaatcttgaa aaagagcaca tatatgggct tcttttttat    77220

aagtgttcgc agactagtat cattaacttc accctgggaa cctgtagaaa tgcaaattct    77280

taggcctttc cccaaactta ctaagtcaga ctctgctatt ggtgttttta acaagacccc    77340

tgggtgattt tgaaactcat gaaagttcga gaattactga ttcattgcat agagcaaggc    77400

tgaactgtgt agacattttt atatgtaaat aagaaaattg tgttgctttt tctgtatagg    77460

tctcactggt tagcttaact gcaaatgcct tgggttactc agaacttggt gccatcaaat    77520

ccctcagaac actaagagct ctgaggccac tgagagcttt gtcccggttt gaaggaatga    77580

gggtaagact gaatgcctta gagtttgtca gaattattat tgagagcaga ctgacacttt    77640

gtaccatgga aatgtcaaat ttatggagaa tttgtgtctt acacattcat actgacatag    77700

ctaatcaatc aaaaataata tttaccagat gcccataata cttggcactg ctggagtcac    77760

tcacagagta gtatattgcc agagggattg tttctgatta gctagatttt cacttcttgg    77820

aaaatctcta tagttatgct gctgatttga atcaagatta tttatgttca cttcatttat    77880

aaatgtgcag gaaatcctac tcgctgtagt ttaagcctac caaatcattg ctcatcattt    77940

cttcactact ccgctgtgat acactttgag ccttttgatg tttgaatcag gccttttagt    78000

tcttaaacac aggctgaaat ggctaaaaag taggtcaact ggaaatctaa cgctcattta    78060

gaagggtggt acaaaagaac agaggagttt gtgctgacat ttgtcgtccc ctgaggcaca    78120

aaacctgaga ccacataccc tcaccaccta gaaaatgatg atgccttgtc tcagttgttt    78180

tagctggttc aaagaggatt ttaaaaaaat gatacttttt gtgatatttg aaaataagtt    78240

gcttagactt tatctgcatg ttatagtgat actagctcat attttctaac taagaaaata    78300

gttacttaga ctttatctag tgttacaatc acaactagag atgaatggtg tgtgtagatg    78360

tgtgtctgta tatgcatggt tacatagaaa agtgttatta gcggtaaaat tctttttact    78420

ttaccaatta gaaagaacag tttttgcagt agaaggctta ataaacaaaa ggtatcaatc    78480

tttcagtacc agaatactgt ttatattttc tgtgtggaat ttgatcccca agtggtctct    78540

tttactctca aattttggac agcaaattgt atggtttgta tgattttttg aaagtgatgt    78600

tcacttctat attcatgcca ctgtttatac tcttaattat ttttggcatt tgctgttagt    78660

tccatccttt gaggtaaatt tgctacatgt gtgttattac ctcttgagaa aacattctcc    78720

aatataaaat tcgttgtata ctcttctgat ttataatttt aaaattctta gttggagcta    78780

ccagagtcta gtttctaccc aatattcaac tttgaaacag atttttttaa tcatttgact    78840

gttcttttaa taatgtttaa aaataagtaa atatttgttg ttggcttttc acttattttt    78900

ccttctcatc ctgtgccagg ttgttgtaaa tgctctttta ggagccattc catctatcat    78960

gaatgtactt ctggtttgtc tgatcttttg gctaatattc agtatcatgg gagtgaatct    79020

ctttgctggc aagttttacc attgtattaa ttacaccact ggagagatgt ttgatgtaag    79080

cgtggtcaac aactacagtg agtgcaaagc tctcattgag agcaatcaaa ctgccaggtg    79140

gaaaaatgtg aaagtaaact ttgataacgt aggacttgga tatctgtctc tacttcaagt    79200

agtaagtaat cactttatta ttttccatga tgtgtaatta aaatgagtct aaagtttttc    79260

ttcctcataa tgagatatcc acctgttaga atggctatta tcaaacagat aaatgacaat    79320

aaatgctggc aagaatgtga agaaaaggga acccttgtac attgttggca gggatgtaaa    79380

ttagtatagc ttttatggaa aacagtatgg aggtttctca aaaaactaaa aatagaacca    79440

ctatgtgatc caacaattcc attactgggt atatatacaa aggaaattaa atcaacatgt    79500

caaagagatg tctgcactct cacactcact gcagcactat tcacaatagc caaaatatgg    79560

aaacaaccta attgtccatc aacagatatg tggataaaga aaagtgtgtg tgtgtgtgtg    79620

tgtgtgtaca tatatgtata tgtatatata tacacacacg tatttctata tacacacgta    79680

tagatataca ctgtatatgt atatatctat acacatatat agacatacac agaaacagtg    79740

tttgtgtatg tgtgcgtgta tatagaagta gtcagggaag gggcagagcc tgtggcacta    79800

agaaactgag aaaatgtaca agacttttgt tttcagaatt actatgtccg cacaacagaa    79860

aaagtatttc aaaaagtaaa tgcgcttgaa tgtatttgtt ttcagtttag gaaactgctt    79920

ctttttgtag agtgccttaa aatagtatgt tcaacaatat taaaaagatt ttcaaaaata    79980

agccctcgtg attgatgatt ggtaataatc atttaaaaac ttattggatg tatatatatg    80040

tgtgtgtata cacgcacaca cacacacaca cacccctata gacatacaca atgaaatagt    80100

attcagcctt taaagaagaa ggaaatcctg tccttttata caacattgat tcacctggag    80160

gaaattaagt gaaataagcc aggcacagaa agacaaatga cacatgatgt cacttatata    80220

tggaatctaa aaaacacaaa ctcacagaaa cagaaagcag aatgacaatc accaggggct    80280

gggggatgat gggagatgtt ggtcaaagga tacaaaattc aattcgacag gaagaataca    80340

ttctgtagag ctattgtaca gcatggtgac tatagttaat aataatatat tatatacttg    80400

aaaatagcta agtgagtaga tatgttttct catcagaaaa aaataagtat aagaagcgat    80460

aattatatat tacttagctt gagttagcca tttcacaata tatatatatt tgaaaacatc    80520

attttgtaca acataaatat attcattttt atttgtcaat taaaaaatga atatattttt    80580

gaaaagcaat taaaataaaa atgcatatac attttaggaa ctctatatag atgcactaaa    80640

actatataaa aatgatataa tactatacaa caataaaata aaatttttct tcctctgtgt    80700

ttacaaatac ttccttaggc ccatctgcct agattcctct taccatgatt gaactatctt    80760

ttctgcccca cgctggaaac atgatggttc taaaaacttt attgtctccc tgactatgca    80820

tttggtagca tagccaagtc ctttgttact gggagtttaa tctaggcact cattgttttc    80880

ctcccttcct actctgagga aagaagtgct ggccccaagg ggggttgaaa aggggtgtgt    80940

gtgtgtgtgt gtatgtgtcc acacgcgtgt gtgtagatag agaaagagag agagactttc    81000

aaataggaaa attgctctct tgcaaatgaa aactttccaa ttaagactat tgtgtctgct    81060

atgcactcat aataattcat tcagctattc aactgactgc agtattaaat ctccactagc    81120

tcctggacac aatccactta cacgatcctc aagactatta aaatagtcag gaaaggggaa    81180

gagcctgtgg cactaaggaa ctgaaaaaat gtacaagagt tttattttca agatcattat    81240

gtcaacggag cagaaaacaa atatttaaaa aaggaaatgc agtagaatat attgttttca    81300

gattaggaaa ctgcttcctc ttatagagta atcacctcaa aatagtatga tcaacaatat    81360

taagaagatt ttcaagaata agctgtcatg attggtgatt ggtgtaataa tcatttagaa    81420

aagaataagt agaaaggaag cattaagata aataatgcag catacttttg agcttgtctc    81480

atgctgctac tatacacatg aaattttttc atcaaagttc atgatatatt tttatataaa    81540

cacatcagag tcaaagattg ttcatattgt ttttatgata gcatattgtt acagtagatc    81600

attatttaat tatatatgct aaatatccac ataagatgtt atagaggaat ataaatttga    81660

agtattttca atgcatatcg caaaacattg ccccaaaagt gaatacaaat ttcaagctta    81720

tttatatgcc tgtattgaat acatgtcaaa tagaattttg atcaattatt caatttattt    81780

tctaaaatta taattttggg aaaaaagaaa atgatatgac ttttcttaca ggccacgttt    81840

aagggatgga tggatattat gtatgcagct gttgattcac gaaatgtaag tctagttaga    81900

gggaaattgt ttagtttgat taaatgtata tttctacaat attgtaattt agtgatattg    81960

tcaataaaat aaaattatgt gcttaattta taaaacccat ctatattata aggataaaat    82020

atttaatcat actatttctt tcaaaattat cataggatga ttttctctaa tcactctgta    82080

tcttttaaca tatcttttct agtatttagc aaggcacctg acacaaaact ttattgtatg    82140

tattttcaaa atgagacatt ttatttttgg ctctgatagt cctggtcatt tgtgcattag    82200

aagttctcac aggcaatatt ttttatctgt aatatatttc ctccagcttt tgatcttcct    82260

tataatagga aggatatgac taaaaacggg gacaaaaata aacaatttag tgtttctctt    82320

gggaaagtga gattaagtgg tagaagggag ggacttccct aatctacttt atacatacca    82380

gtactttgaa ttcttttcta taattttcat taatttctca ctatttaatg aggaatgaag    82440

tcacattttg aaaaaaaaaa aaaaagagat tgatttctgg tatgccagag catgataata    82500

aagctcaaaa tgctctttcc ctagcaccag cagctagctt tctgagtgaa gaattcctga    82560

ggtttttttt tttctttttt ccacttcata aaaacagaga gggagcaaga aagcatgaaa    82620

agccctgcat tgtatctcta taagtgctat caggaattcc agttatgaga tttttctgaa    82680

tagtaataat aatttattga ttatcactat tcactgtgcc aaggactttc tcacattatc    82740

ccatttaatc ctaaatgaca accttattgt ataggtgata ctagctctat tttactactg    82800

aagcaaagag gcttaatgcg ttaaatggga aaacaagttt ttgaaccctg accacaaata    82860

atggctcata cccactttcc acagtggttc ttaccttttt gattaattaa ttcaatgctc    82920

tctccacctt ccttatcaat agcttatatg ccatgaaaca ttttcagttt cttctttaat    82980

aacttagcag accttttccg ctgcaaaact cctggaattt ccagcacatt acaaaagatg    83040

aaagccaatt gagcactaca tttatgaaaa gttgctggat cttgaacttt aattagtaaa    83100

ttgcatcaga taaatgcaaa tttaaaccaa aataaaacat tatctacaca cctaccagat    83160

tggcaatacc aaaaagtctg acaataccaa gttttaccaa ggataaacag caataagaac    83220

actcgtacaa tgctgatagg aaaaaaaata gttaaataat cctttaaaaa cagttgggta    83280

tgatcacatt atttgagaaa gttaaagata ttttttaata ctgcaattct actttgaaca    83340

acgtatccta aagaaactta tgcacatgtt taggataatc tatgtacaaa aatgaatata    83400

actttttttt gcacttgcaa aaaactggga gcaactcaaa aacagtagaa ataggcaaat    83460

aattgaatac tatatagtga tgaaaatgaa tgaataccgc catatacaac cacatggatg    83520

agccttaaaa atacaacatt gagttaaaga aactagacac atactataat tctacttata    83580

taaagttcga aattgacaaa actaagctta ttgttcaaaa ctgcatactg aggtgttaac    83640

ttgaaagaaa aagcagggac atcattacca taaaagtcag gataatgatt acctccagca    83700

gggatgatgg agtttatgtt tgagaagggt acaccaaggg tttctgaagt tgtagcaatg    83760

tcctgggtta tggatttcac ttataaaaca tattatattt tgcatttatg tattatgcac    83820

tttcctgtat gtatattgtc ttttaaaaat tttaaaaata taattttaca tcactgttaa    83880

ctaaactcac atacacaaat aaaatctcat cgaagaatag cagttttaca atattcctga    83940

tattttccat tttgctgtat ttccttagaa acaaaattat gctggtcata atcctctaaa    84000

ttgatttcat aacacagtgg gttataactt gcatctatta tcatcatcag ggattggtta    84060

actgagttgg ttagaacaat gtcctattag acctgtgaaa gcttacagct aaggcgcaaa    84120

cctactatca cacagttttc taaacaaaag tggattagac aagagatagt atcattgtta    84180

cagaaacagt ccctactgaa taggataaag caatagattc attttcagaa aggaaagatc    84240

aacctatata cctacatgca gacctactac aatgattctt gcctatctaa agaaatgtat    84300

tataccaaac ccttacactt agcaattact actggccgcc actgttctaa gcatatttat    84360

atgttaatat agttaatctt cacaaccaca ctatgaggtt taagtttgat tattttcatc    84420

tcacagatga gaaaactgag tcagagaaag taaatcttaa aagttttgac atagaataat    84480

gtgacgctga catctctttt gtaagaagag gaaatcttta atttgcatgc tgtgttggga    84540

actttgctta gaaaggaaag tgcattcata atctgggcat ttgttgggtg aaattgtcta    84600

taatcattca gacttctata tggttatttc attttcccag gtaatgaata gtcttgcaga    84660

actcttcaat aagcatgtga gatttgaagg ttcataaaat ctgtttagtg tttggtttat    84720

tttcattcca gagattaaaa catgcttaga taattaaaaa ctcactgatg tactttttgt    84780

gaaacaagta ctagatataa tggttacaat tcttcatatt ctttaggtag aattacaacc    84840

caagtatgaa gacaacctgt acatgtatct ttattttgtc atctttatta tttttggttc    84900

attctttacc ttgaatcttt tcattggtgt catcatagat aacttcaacc aacagaaaaa    84960

gaagataagt atattaaaac ttcatccttg ctctgaaata tgaactaaat atttcatact    85020

ctttccttta gcctccaaaa tgcaatcacc aaaaaaagaa tataaaattc agaaattatt    85080

ttgagacatt tgataatcga taagctttta agcaattaat aattcagata gcatgttttt    85140

gatattttta gtctagaaat atgactaata tggcataatt tatatattga ataaaggcat    85200

ctctataaat acagatatta gtaacaatag aatgaaatgt gggagccaat tttcacatga    85260

ttactaaggt ggattttata gccagcaaag aacacaattt taacaagtgt tgctttcatt    85320

tctttacttt ggaggtcaag acatttttat gacagaagaa cagaagaaat actacaatgc    85380

aatgaaaaaa ctgggttcaa agaaaccaca aaaacccata cctcgacctg ctgtaagaat    85440

aacatatttt cattgcctgt taaaactata ttacctaacc gtttcacagc ccgaatttct    85500

agaaactagt tatttttgtg gatttgtaac acaaagtttt ttaccttaac aatgggacta    85560

gctagcctaa atagcttgaa aaatgtactt tacatatata atatgtataa attatataat    85620

gcataacata ttttatatgt aaacatataa aatacataga aataaaattt gctatactta    85680

agtgccagtg gtatcataca agctgatgtc attaagacac ttctaataac atcaaaaata    85740

aaatacatac atacataatg tgaaaatatt aaatgttctc agagtacaga ggagacagat    85800

cggaataatt ggtacgtcac agattggcct cagtttttgt ccaactctgc agattgaatg    85860

gaatcattaa tgaaacaggc cacaggtttt gcttttttct ggttaaacaa aaaaaagaca    85920

aacctcatat tttcccctac tatcccaccc ttaaatgaga tgatatcatt ctttgtaggg    85980

ctttttattg gctcttccag gtgtacattt gccagtgata ctgttcgttc agtttggctg    86040

ctgcagggag ttgctgccag gagaatcgct aagtttttct atcactcctg aaggactagc    86100

tcatatatta agtctcagaa aatcttcccc aacgtatacg tggtataaaa cacttcagtg    86160

tttctcagaa atcttgactc tataaatcta ttggtgacaa tataaaacag accgtaatta    86220

agtgttcagt tggtaagccg gccaataact caaagaaaat ggatagctat attgggtcaa    86280

acacaaaggg tgtacaactt gagcctagtc tttaggaaat aatacaattt gaatgaatag    86340

agagagaagc agagaacatt tactgtatga gaaaatgtat acttcatagc catatagaca    86400

aatatatcag tgcagaatag tgatgcattt gaattagtga gtagtagaca ctggttttcc    86460

gagttacatg agacaaggtt accatacgag tctgaagaaa tttgttctaa ttaagcaata    86520

caaatgcaat atagttaaca gaacagccta gtaatgtgaa aagaaagatt ttagagagtt    86580

taacctagag actggtgtgg aacaatatta gaggcaaaat aaccctcggc catagacaag    86640

aagataaacc cttacataca agaagatagt ccataatctg tgtccaacca gcaggactgg    86700

aactactcca ggagtgaagt tagccaataa gaagactcaa ttgggatgaa acacaggaaa    86760

agagggagga tgcaatgaaa aaactgggtt caaagaaacc acaataaccc atacctcgac    86820

ctgctgtaag aatagcatat tttcattgcc tgttatgaaa cacaggaaaa gagggaggat    86880

atgtaaataa cagagaatct aaaatataag ctagttgata ttttgtgaaa ctgttggttc    86940

cactatcata tactgaagtc atatgaaggc actgggaaaa atagtgttag agcctatgaa    87000

atgtccagac tgaaataagg attttagcat tgtcagaaca aaattcaatt gagctctgaa    87060

acacagattc atttttgaaa aataattaga atagagaaaa aaacaaaatt ctcagaatga    87120

ggccttgcat acttcatcaa gatataggaa gaaataaatc aatgaagaaa tgagcttgag    87180

tttgtttcca tcaaatgaca tggatttacc tgtagtggta ggggtgtgtg gaaaaagttc    87240

aacacattca gctagaatat tatcagtgtc aatttggcaa tttagcaagt aactagtaaa    87300

atccatttat tcctgcattg acaatatgta ctatgtagta tgctaagcat ttgaacttaa    87360

atatcgaaca gtatggagtc tagttaatgc aacggatagt aatcaaatag tcctgccaaa    87420

aaatggaagt atcccagaaa aaaagggata ctttcagctg tgagagctga ttagggggaa    87480

ggggctgatt aatcagggaa gttagggaag gctttattaa aaaaatatac tagctgagga    87540

tggaaaaaga atagaaagca tcaatagcca gagtgggatg agaagagccc tgtagaaggg    87600

gaatgaattt gtgaaggtcc ttatgtagga gggctggtga gactggagtg cagaaagtca    87660

aggttcattt gggacacact gagaataaag aggttaggat aagcccaaac ttttctgggc    87720

cttggaggcc gtgttaagga gtagttttca tcctaagagc agtaagaaac cgttaacgtg    87780

gacccagtca gtctgggctt tgtggtgatc actcaatcag tttcacagag gccgtgtgaa    87840

tacattgtag acttgttttg gagctatttc agagatggta ggtagcctga accatagcaa    87900

tgtgcagatt aataaaagtg gatggatttg tgagctatca ccagagtgaa atttaaaagt    87960

ttgtctatta attgaatatg ggaactaaag aaggaaccaa caagaatgac tggtgtcttt    88020

ctgctttgca caactggata aatactgatg tcatgcagga aatgaagaag ggacagaaag    88080

tggtgagaaa attggagatg ctagtttgca gaatttggca aacgagtcag agtgagagag    88140

tgagaggaag gaggaaggga gagaaatgat gaatatttag aagtagcaaa ataaaggttt    88200

cttaagattc agagattagg tttaaaggaa agcaaaagga attttagaga ggaaaagatc    88260

gaagacagag ggaataatta cggcataaaa atgcacaaga tgtgggacaa ggacatagtg    88320

gtctagggta gctttagaaa gaaaaagggg ctgagtcctc taatgaattt ggagtaatat    88380

atgaaaagaa catggaaatt aaaataatat gaaatgcaaa aggaaacaga ggagtttatt    88440

taaactgttt aaatttaatg ttctaaaaaa agtaaaaata gagggcaaga gaatggaaat    88500

ttatgagaag tttggaatta tctttggagc aaatgaagga caaaggattg ctaattgtta    88560

aatctgaagg gccaagatga agttagagaa cataaatttt tggtgaataa gatcttcaga    88620

attatacatc ttgttccagc atatttgaca ccctaggatt taaatgggag aacagaacac    88680

agagactcga gactggagtt gtacattgag atgtctgtct cattggacaa ctctatgaac    88740

agggaatcta aacagttttt tattagtcat ggtgatatta aaattaagac caaatttctg    88800

cttttaagat attttgaact tactatactc taggagccat atctgagaga aaaatgatac    88860

tgctcctgct tttgaggggc ctcaaaacaa gtggaaggga aagaaaacta aaattgaata    88920

agagcaaacc atttgcaata caatgccata cattttatga tcaatgaaag cactcagttt    88980

tctgagagca ctaagtgctt taaactcaaa actgagttag aattcatgag acagagaagg    89040

agtgggggac atgtgtttta gacagaatag tagacagata aactatgtaa aatgatacag    89100

tagaacctgc ctaagcttct aagagtggta ggcaggaaat atcagagggt ggaagtaagg    89160

ggaagatgcc agacttggaa agttaaacta cagtaaatta ataattaata aggaagggtt    89220

tgaactaaaa gtagacacat ttattgggtt gaaaaaggcc ctgagaagac agatccagct    89280

ggagtaatag aaatctagtt cagcaggcca aatacgcatt cagagaaaag agcaaaacaa    89340

aatagaacaa gtagtgtttg atgtccaaaa atcaccattg gaagtaatag aagcctccca    89400

atagaaagag ggcagaacac taagatgtag aatccaggcc actaaaagtg tcaggatctg    89460

ggaaagcaag ccattaggtg tatatgtagc agagtattag tcattctagt tgagaaggta    89520

gagaaaggca gcccaacaga ggttaagtca agaccagatc cctagattac ctgagaaaca    89580

aagcagatac gtgcaaaatg gaacaataca gaaaccaatg atcagaactg gtttacaagt    89640

tggggacttc atttcataag caagacataa ggcaattagt acttggaaat aaggtccaaa    89700

tagactaggg caaagattga atatttccat tgtgactttt taaaagataa ttttattctt    89760

acagaagagt tactcataat gaatactcta atgaatctat acacagtgtc ctcttgtttt    89820

aacatcttat gcaaccatag atcagttctc acaactaaga aattaatctt gatataatac    89880

cattaaataa aatacagaac tgagtcagat ttcaccagtt tttccactga agccttttct    89940

ctagaatgat gatttttaaa acatcttagc tgaactttaa aatgaaattt aagatgctgt    90000

agctttagtg agagaatata aagtcagaaa tcagacgaaa aatttaaaaa gagagaggaa    90060

aacttggaga agtatttatt tattagttgc ttaaagtaaa attaataccc tcccaacaca    90120

tgggataaaa aattttatta catgacaaat atttactaac tgtccgtcat aacatgatgg    90180

tgttctgtgc actgagaaca taatacgtga gtttataaaa cctggtatca atgtgagtat    90240

aaataaaaca aatacatttg aatacagttg aatatacaat atacaaaatt ttcttccaag    90300

tataaaacga aaataaaata cactactttc tttaatagaa tagaacattg taataatgtt    90360

ccattgcatt tgaccctcac ataaatgcta tgaggtagca ttaagagata agatttgagg    90420

ctgggcatgg tggctcatgc ctgtaattcc agcactttgg gaggtcgagg tgggcagatc    90480

attaggtcag gagtttgaga ccagcctgac caatacggtg aaatcccgtc tctactaaaa    90540

ttacaaaaag tagtcgggca tggtggcatg tacctgtaat cccagctact caggaggctg    90600

aggcaggagt atcgcttgaa cccgggaggc agaggttgca gtgagccaag atcgtgccac    90660

tgcactccaa cctgtgcaac agagcgagac tccatctcaa aaaataaaaa aaattaaaaa    90720

aaagagagag agataagatt tgagatctga catggagctt ccctatttac actacttacc    90780

tgctttgtga cctaaggcaa gttacctcag ctctccaatc actggttttg caaggaattt    90840

ttttttttgt aaaatgttgt gaggattaaa gatgtgtttt tataaaagct acattttttg    90900

ttgctttctt aaaatcagaa gaattgaatt cgattttttt taaggtttct aatggaactt    90960

ttacatatta tttgttccag aacaaattcc aaggaatggt ctttgatttt gtaaccaaac    91020

aagtctttga tatcagcatc atgatcctca tctgccttaa catggtcacc atgatggtgg    91080

aaaccgatga ccagagtcaa gaaatgacaa acattctgta ctggattaat ctggtgttta    91140

ttgttctgtt cactggagaa tgtgtgctga aactgatctc tcttcgttac tactatttca    91200

ctattggatg gaatattttt gattttgtgg tggtcattct ctccattgta ggtaagaaga    91260

ggtgctttta ttcagttaag gaatatagtg gtaaaaatat gtgttttaaa actttagagg    91320

tgtttttcac taatctttct cattcatccc aaactcccaa ataaaaatct aatagtccat    91380

tgttttagtt ttagtttgcc atttctctaa ttgcatgctg tgcttgaaat gatgagtgga    91440

atacaaggaa tttatatttt cagctttcat ttattctcat ttaatatttt catctgttct    91500

catctcagaa gacaataact gcaactttgg tagaatagtc ttgtacctgg tcatactcct    91560

gtggtattga cagttactgc tttgaataaa caatcaatcc acacacatat atacataaat    91620

catttgaagt agtcacataa ttcataaata tgacctctta aataattgga atagtgtata    91680

tgtgcagtta tatatataat aacacatata taagtttcat gttatctttg ggtgcagaca    91740

gttttctgtg gtttgcaata tctctttttg gaagcagata gtttgtttga aaatccaaaa    91800

cagatttgtt atcatcaatg atacattaat gttaggatac atacatacat taagtcctag    91860

gaatgcaaaa gatttattgg aaaaaatata tatatacagt gtttatgtat aagatattaa    91920

atgaggtact ggaagtaaat ataagaagat ttaagagaag gttctaccta tttggggaaa    91980

cagaacattc acatggaggg gaaaattata tagcactctt taaactactt tctttagtcg    92040

aatagaacat tgtaacaatg ttccactgca tttgattctc acataagtgc tatgaggtag    92100

cattaagagg taagatttga gatctgacct ggagcttccc tatttacact acttaccttc    92160

tcagtgacct aagagaagtt acctcagctc tccaatctct ggttttgcaa ggaatttttc    92220

tgtaaaatgt tattgtgagg attaaatcag attatgtata tatatgcact tagcactgtg    92280

cctagcatga agaaaagact tagtaaatgt tcagtttgac cacaagaaaa agttgatatt    92340

atcaccattt actcatgcat aaaagcaagt gccaggattc agtcccaagt acatctgtct    92400

ccaaagccta tgttttcttc tgtacatcac gctgcctact cccaaataac atagaatctc    92460

agaaagtaaa gaactctcat attcctgacc caaaatcata cacctttagt tcttatgcaa    92520

atactagaac tagtattttg gacatataaa ttaatttctg tacttggcca ctgtatgctt    92580

catgatgtct ttggaccttc cagggttgag tcattttttt gatagatgct ttccttgaac    92640

taggaaaaat ggcccttatt atcttcattt aatataaaga tgtaaatgtt ataacaccaa    92700

acataccagt ttcattttgc tcaacaaaca ttgcagatta tttgcatata tacatgtacc    92760

taactgtcct gttcacattt tgtaaaacta atgtacttat gtaaactttc atttgctact    92820

attaagtata acaatatttt tgttatttgt tgattttcta caggaatgtt tctggctgaa    92880

ctgatagaaa agtattttgt gtcccctacc ctgttccgag tgatccgtct tgccaggatt    92940

ggccgaatcc tacgtctgat caaaggagca aaggggatcc gcacgctgct ctttgctttg    93000

atgatgtccc ttcctgcgtt gtttaacatc ggcctccttc ttttcctggt catgttcatc    93060

tacgccatct ttgggatgtc caattttgcc tatgttaaga gggaagttgg gatcgatgac    93120

atgttcaact ttgagacctt tggcaacagc atgatctgcc tgttccaaat tacaacctct    93180

gctggctggg atggattgct agcacctatt cttaatagtg gacctccaga ctgtgaccct    93240

gacaaagatc accctggaag ctcagttaaa ggagactgtg ggaacccatc tgttgggatt    93300

ttcttttttg tcagttacat catcatatcc ttcctggttg tggtgaacat gtacatcgcg    93360

gtcatcctgg agaacttcag tgttgctact gaagaaagtg cagagcctct gagtgaggat    93420

gactttgaga tgttctatga ggtttgggag aagtttgatc ccgatgcgac ccagtttata    93480

gagtttgcca aactttctga ttttgcagat gccctggatc ctcctcttct catagcaaaa    93540

cccaacaaag tccagctcat tgccatggat ctgcccatgg tgagtggtga ccggatccac    93600

tgtcttgaca tcttatttgc ttttacaaag cgtgttttgg gtgagagtgg agagatggat    93660

gcccttcgaa tacagatgga agagcgattc atggcatcaa acccctccaa agtctcttat    93720

gagcccatta cgaccacgtt gaaacgcaaa caagaggagg tgtctgctat tattatccag    93780

agggcttaca gacgctacct cttgaagcaa aaagttaaaa aggtatcaag tatatacaag    93840

aaagacaaag gcaaagaatg tgatggaaca cccatcaaag aagatactct cattgataaa    93900

ctgaatgaga attcaactcc agagaaaacc gatatgacgc cttccaccac gtctccaccc    93960

tcgtatgata gtgtgaccaa accagaaaaa gaaaaatttg aaaaagacaa atcagaaaag    94020

gaagacaaag ggaaagatat cagggaaagt aaaaagtaaa aagaaaccaa gaattttcca    94080

ttttgtgatc aattgtttac agcccgtgat ggtgatgtgt ttgtgtcaac aggactccca    94140

caggaggtct atgccaaact gactgttttt acaaatgtat acttaaggtc agtgcctata    94200

acaagacaga gacctctggt cagcaaactg gaactcagta aactggagaa atagtatcga    94260

tgggaggttt ctattttcac aaccagctga cactgctgaa gagcagaggc gtaatggcta    94320

ctcagacgat aggaaccaat ttaaaggggg gagggaagtt aaatttttat gtaaattcaa    94380

catgtgacac ttgataatag taattgtcac cagtgtttat gttttaactg ccacacctgc    94440

catattttta caaaacgtgt gctgtgaatt tatcactttt ctttttaatt cacaggttgt    94500

ttactattat atgtgactat ttttgtaaat gggtttgtgt ttggggagag ggattaaagg    94560

gagggaattc tacatttctc tattgtattg tataactgga tatattttaa atggaggcat    94620

gctgcaattc tcattcacac ataaaaaaat cacatcacaa aagggaagag tttacttctt    94680

gtttcaggat gtttttagat ttttgaggtg cttaaatagc tattcgtatt tttaaggtgt    94740

ctcatccaga aaaaatttaa tgtgcctgta aatgttccat agaatcacaa gcattaaaga    94800

gttgttttat ttttacataa cccattaaat gtacatgtat atatgtatat atgtatatgt    94860

gcgtgtatat acatatatat gtatacacac atgcacacac agagatatac acataccatt    94920

acattgtcat tcacagtccc agcagcatga ctatcacatt tttgataagt gtcctttggc    94980

ataaaataaa aatatcctat cagtcctttc taagaagcct gaattgacca aaaaacatcc    95040

ccaccaccac tttataaagt tgattctgct ttatcctgca gtattgttta gccatcttct    95100

gctcttggta aggttgacat agtatatgtc aatttaaaaa ataaaagtct gctttgtaaa    95160

tagtaatttt acccagtggt gcatgtttga gcaaacaaaa atgatgattt aagcacacta    95220

cttattgcat caaatatgta ccacagtaag tatagtttgc aagctttcaa caggtaatat    95280

gatgtaattg gttccattat agtttgaagc tgtcactgct gcatgtttat cttgcctatg    95340

ctgctgtatc ttattccttc cactgttcag aagtctaata tgggaagcca tatatcagtg    95400

gtaaagtgaa gcaaattgtt ctaccaagac ctcattcttc atgtcattaa gcaataggtt    95460

gcagcaaaca aggaagagct tcttgctttt tattcttcca accttaattg aacactcaat    95520

gatgaaaagc ccgactgtac aaacatgttg caagctgctt aaatctgttt aaaatatatg    95580

gttagagttt tctaagaaaa tataaatact gtaaaaagtt cattttattt tatttttcag    95640

ccttttgtac gtaaaatgag aaattaaaag tatcttcagg tggatgtcac agtcactatt    95700

gttagtttct gttcctagca cttttaaatt gaagcacttc acaaaataag aagcaaggac    95760

taggatgcag tgtaggtttc tgctttttta ttagtactgt aaacttgcac acatttcaat    95820

gtgaaacaaa tctcaaactg agttcaatgt ttatttgctt tcaatagtaa tgccttatca    95880

ttgaaagagg cttaaagaaa aaaaaaatca gctgatactc ttggcattgc ttgaatccaa    95940

tgtttccacc tagtcttttt attcagtaat catcagtctt ttccaatgtt tgtttacaca    96000

gatagatctt attgacccat atggcactag aactgtatca gatataatat gggatcccag    96060

ctttttttcc tctcccacaa aaccaggtag tgaagttata ttaccagtta cagcaaaata    96120

ctttgtgttt cacaagcaac aataaatgta gattctttat actgaagcta ttgacttgta    96180

gtgtgttggt gaaatgcatg caggaaaatg ctgttaccat aaagaacggt aaaccacatt    96240

acaatcaagc caaaagaata aaggtttcgc ttttgttttt gtatttaatt gttgtctttg    96300

tttctatctt tgaaatgcca tttaaaggta gatttctatc atgtaaaaat aatctatctg    96360

aaaaacaaat gtaaagaaca cacattaatt actataattc atctttcaat tttttcatgg    96420

aatggaagtt aattaagaag agtgtattgg ataactactt taatattggc caaaaagcta    96480

gatatggcat caggtagact agtggaaagt tacaaaaatt aataaaaaat tgactaacat    96540

tttaagttgt gcatcttttc tccttcctgt ccacctattg ttcttttttt cacttttcca    96600

tttcaatttc ttccttatgt attcttgatc tacttttctt tatatccttc tatcctttcc    96660

ttgcgctctc agtatttttc atttaggata ttctccttgt ttcttttctg ttcaccaaat    96720

gtcttgttta ttacagccta tagatcactt agatttagat ccctaaaatt tgctgtcact    96780

ctgtaaagtg cacctcgaga taacttcgta taatgtatgc tatacgaagt tatatgcatg    96840

ccagtagcag cacccacgtc caccttctgt ctagtaatgt ccaacacctc cctcagtcca    96900

aacactgctc tgcatccatg tggctcccat ttatacctga agcacttgat ggggcctcaa    96960

tgttttacta gagcccaccc ccctgcaact ctgagaccct ctggatttgt ctgtcagtgc    97020

ctcactgggg cgttggataa tttcttaaaa ggtcaagttc cctcagcagc attctctgag    97080

cagtctgaag atgtgtgctt ttcacagttc aaatccatgt ggctgtttca cccacctgcc    97140

tggccttggg ttatctatca ggacctagcc tagaagcagg tgtgtggcac ttaacaccta    97200

agctgagtga ctaactgaac actcaagtgg atgccatctt tgtcacttct tgactgtgac    97260

acaagcaact cctgatgcca aagccctgcc cacccctctc atgcccatat ttggacatgg    97320

tacaggtcct cactggccat ggtctgtgag gtcctggtcc tctttgactt cataattcct    97380

aggggccact agtatctata agaggaagag ggtgctggct cccaggccac agcccacaaa    97440

attccacctg ctcacaggtt ggctggctcg acccaggtgg tgtcccctgc tctgagccag    97500

ctcccggcca agccagcacc atgggaaccc ccaagaagaa gaggaaggtg cgtaccgatt    97560

taaattccaa tttactgacc gtacaccaaa atttgcctgc attaccggtc gatgcaacga    97620

gtgatgaggt tcgcaagaac ctgatggaca tgttcaggga tcgccaggcg ttttctgagc    97680

atacctggaa aatgcttctg tccgtttgcc ggtcgtgggc ggcatggtgc aagttgaata    97740

accggaaatg gtttcccgca gaacctgaag atgttcgcga ttatcttcta tatcttcagg    97800

cgcgcggtct ggcagtaaaa actatccagc aacatttggg ccagctaaac atgcttcatc    97860

gtcggtccgg gctgccacga ccaagtgaca gcaatgctgt ttcactggtt atgcggcgga    97920

tccgaaaaga aaacgttgat gccggtgaac gtgcaaaaca ggtaaatata aaatttttaa    97980

gtgtataatg atgttaaact actgattcta attgtttgtg tattttaggc tctagcgttc    98040

gaacgcactg atttcgacca ggttcgttca ctcatggaaa atagcgatcg ctgccaggat    98100

atacgtaatc tggcatttct ggggattgct tataacaccc tgttacgtat agccgaaatt    98160

gccaggatca gggttaaaga tatctcacgt actgacggtg ggagaatgtt aatccatatt    98220

ggcagaacga aaacgctggt tagcaccgca ggtgtagaga aggcacttag cctgggggta    98280

actaaactgg tcgagcgatg gatttccgtc tctggtgtag ctgatgatcc gaataactac    98340

ctgttttgcc gggtcagaaa aaatggtgtt gccgcgccat ctgccaccag ccagctatca    98400

actcgcgccc tggaagggat ttttgaagca actcatcgat tgatttacgg cgctaaggat    98460

gactctggtc agagatacct ggcctggtct ggacacagtg cccgtgtcgg agccgcgcga    98520

gatatggccc gcgctggagt ttcaataccg gagatcatgc aagctggtgg ctggaccaat    98580

gtaaatattg tcatgaacta tatccgtaac ctggatagtg aaacaggggc aatggtgcgc    98640

ctgctggaag atggcgatta ggcggccggc cgctaatcag ccataccaca tttgtagagg    98700

ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg    98760

caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca    98820

tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac    98880

tcatcaatgt atcttatcat gtctggatcc cccggctaga gtttaaacac tagaactagt    98940

ggatcccccg ggatcatggc ctccgcgccg ggttttggcg cctcccgcgg gcgcccccct    99000

cctcacggcg agcgctgcca cgtcagacga agggcgcagc gagcgtcctg atccttccgc    99060

ccggacgctc aggacagcgg cccgctgctc ataagactcg gccttagaac cccagtatca    99120

gcagaaggac attttaggac gggacttggg tgactctagg gcactggttt tctttccaga    99180

gagcggaaca ggcgaggaaa agtagtccct tctcggcgat tctgcggagg gatctccgtg    99240

gggcggtgaa cgccgatgat tatataagga cgcgccgggt gtggcacagc tagttccgtc    99300

gcagccggga tttgggtcgc ggttcttgtt tgtggatcgc tgtgatcgtc acttggtgag    99360

tagcgggctg ctgggctggc cggggctttc gtggccgccg ggccgctcgg tgggacggaa    99420

gcgtgtggag agaccgccaa gggctgtagt ctgggtccgc gagcaaggtt gccctgaact    99480

gggggttggg gggagcgcag caaaatggcg gctgttcccg agtcttgaat ggaagacgct    99540

tgtgaggcgg gctgtgaggt cgttgaaaca aggtgggggg catggtgggc ggcaagaacc    99600

caaggtcttg aggccttcgc taatgcggga aagctcttat tcgggtgaga tgggctgggg    99660

caccatctgg ggaccctgac gtgaagtttg tcactgactg gagaactcgg tttgtcgtct    99720

gttgcggggg cggcagttat ggcggtgccg ttgggcagtg cacccgtacc tttgggagcg    99780

cgcgccctcg tcgtgtcgtg acgtcacccg ttctgttggc ttataatgca gggtggggcc    99840

acctgccggt aggtgtgcgg taggcttttc tccgtcgcag gacgcagggt tcgggcctag    99900

ggtaggctct cctgaatcga caggcgccgg acctctggtg aggggaggga taagtgaggc    99960

gtcagtttct ttggtcggtt ttatgtacct atcttcttaa gtagctgaag ctccggtttt   100020

gaactatgcg ctcggggttg gcgagtgtgt tttgtgaagt tttttaggca ccttttgaaa   100080

tgtaatcatt tgggtcaata tgtaattttc agtgttagac tagtaaattg tccgctaaat   100140

tctggccgtt tttggctttt ttgttagacg tgttgacaat taatcatcgg catagtatat   100200

cggcatagta taatacgaca aggtgaggaa ctaaaccatg ggatcggcca ttgaacaaga   100260

tggattgcac gcaggttctc cggccgcttg ggtggagagg ctattcggct atgactgggc   100320

acaacagaca atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc   100380

ggttcttttt gtcaagaccg acctgtccgg tgccctgaat gaactgcagg acgaggcagc   100440

gcggctatcg tggctggcca cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac   100500

tgaagcggga agggactggc tgctattggg cgaagtgccg gggcaggatc tcctgtcatc   100560

tcaccttgct cctgccgaga aagtatccat catggctgat gcaatgcggc ggctgcatac   100620

gcttgatccg gctacctgcc cattcgacca ccaagcgaaa catcgcatcg agcgagcacg   100680

tactcggatg gaagccggtc ttgtcgatca ggatgatctg gacgaagagc atcaggggct   100740

cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg cccgacggcg atgatctcgt   100800

cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg   100860

attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag cgttggctac   100920

ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg tgctttacgg   100980

tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg agttcttctg   101040

aggggatccg ctgtaagtct gcagaaattg atgatctatt aaacaataaa gatgtccact   101100

aaaatggaag tttttcctgt catactttgt taagaagggt gagaacagag tacctacatt   101160

ttgaatggaa ggattggagc tacgggggtg ggggtggggt gggattagat aaatgcctgc   101220

tctttactga aggctcttta ctattgcttt atgataatgt ttcatagttg gatatcataa   101280

tttaaacaag caaaaccaaa ttaagggcca gctcattcct cccactcatg atctatagat   101340

ctatagatct ctcgtgggat cattgttttt ctcttgattc ccactttgtg gttctaagta   101400

ctgtggtttc caaatgtgtc agtttcatag cctgaagaac gagatcagca gcctctgttc   101460

cacatacact tcattctcag tattgttttg ccaagttcta attccatcag acctcgacct   101520

gcagccccta gataacttcg tataatgtat gctatacgaa gttatgctag taactataac   101580

ggtcctaagg tagcgagcta gcagcttcgg ttttgataca ctgtttacag cctgcgaagg   101640

tgactcactc gtgttaataa gactctttta cgg                                101673


<210>  21
<211>  197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  21
cagcctatag atcacttaga tttagatccc taaaatttgc tgtcactctg taaagtgcac       60

ctcgagataa cttcgtataa tgtatgctat acgaagttat gctagtaact ataacggtcc      120

taaggtagcg agctagcagc ttcggttttg atacactgtt tacagcctgc gaaggtgact      180

cactcgtgtt aataaga                                                     197


<210>  22
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Ala Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Glu  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  23
<211>  2000
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Ser 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu 
        275                 280                 285             


Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr 
    290                 295                 300                 


Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 
                325                 330                 335     


Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 
            340                 345                 350         


Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 
        355                 360                 365             


Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr 
    370                 375                 380                 


Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
385                 390                 395                 400 


Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
                405                 410                 415     


Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
            420                 425                 430         


Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met 
        435                 440                 445             


Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 
    450                 455                 460                 


Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 
465                 470                 475                 480 


Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 
                485                 490                 495     


Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu 
            500                 505                 510         


Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn 
    530                 535                 540                 


Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 
                565                 570                 575     


Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Met Ser Ser Arg Met Val Pro Gly Leu Pro Ala 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Thr Gly Gln Leu Pro Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser 
        675                 680                 685             


Tyr Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg 
    690                 695                 700                 


Ala Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val 
                725                 730                 735     


Phe Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu 
            740                 745                 750         


Val Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Tyr Val Lys Asn  Lys Met Arg 
    1010                 1015                 1020             


Glu Cys  Phe Gln Lys Ala Phe  Phe Arg Lys Pro Lys  Val Ile Glu 
    1025                 1030                 1035             


Ile His  Glu Gly Asn Lys Ile  Asp Ser Cys Met Ser  Asn Asn Thr 
    1040                 1045                 1050             


Gly Ile  Glu Ile Ser Lys Glu  Leu Asn Tyr Leu Arg  Asp Gly Asn 
    1055                 1060                 1065             


Gly Thr  Thr Ser Gly Val Gly  Thr Gly Ser Ser Val  Glu Lys Tyr 
    1070                 1075                 1080             


Val Ile  Asp Glu Asn Asp Tyr  Met Ser Phe Ile Asn  Asn Pro Ser 
    1085                 1090                 1095             


Leu Thr  Val Thr Val Pro Ile  Ala Val Gly Glu Ser  Asp Phe Glu 
    1100                 1105                 1110             


Asn Leu  Asn Thr Glu Glu Phe  Ser Ser Glu Ser Glu  Leu Glu Glu 
    1115                 1120                 1125             


Ser Lys  Glu Lys Leu Asn Ala  Thr Ser Ser Ser Glu  Gly Ser Thr 
    1130                 1135                 1140             


Val Asp  Val Val Leu Pro Arg  Glu Gly Glu Gln Ala  Glu Thr Glu 
    1145                 1150                 1155             


Pro Glu  Glu Asp Leu Lys Pro  Glu Ala Cys Phe Thr  Glu Gly Cys 
    1160                 1165                 1170             


Ile Lys  Lys Phe Pro Phe Cys  Gln Val Ser Thr Glu  Glu Gly Lys 
    1175                 1180                 1185             


Gly Lys  Ile Trp Trp Asn Leu  Arg Lys Thr Cys Tyr  Ser Ile Val 
    1190                 1195                 1200             


Glu His  Asn Trp Phe Glu Thr  Phe Ile Val Phe Met  Ile Leu Leu 
    1205                 1210                 1215             


Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile Tyr Ile  Glu Gln Arg 
    1220                 1225                 1230             


Lys Thr  Ile Lys Thr Met Leu  Glu Tyr Ala Asp Lys  Val Phe Thr 
    1235                 1240                 1245             


Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys Trp Val  Ala Tyr Gly 
    1250                 1255                 1260             


Phe Gln  Thr Tyr Phe Thr Asn  Ala Trp Cys Trp Leu  Asp Phe Leu 
    1265                 1270                 1275             


Ile Val  Asp Val Ser Leu Val  Ser Leu Val Ala Asn  Ala Leu Gly 
    1280                 1285                 1290             


Tyr Ser  Glu Leu Gly Ala Ile  Lys Ser Leu Arg Thr  Leu Arg Ala 
    1295                 1300                 1305             


Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe Glu Gly  Met Arg Val 
    1310                 1315                 1320             


Val Val  Asn Ala Leu Val Gly  Ala Ile Pro Ser Ile  Met Asn Val 
    1325                 1330                 1335             


Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile Phe Ser  Ile Met Gly 
    1340                 1345                 1350             


Val Asn  Leu Phe Ala Gly Lys  Phe Tyr His Cys Val  Asn Met Thr 
    1355                 1360                 1365             


Thr Gly  Asn Met Phe Asp Ile  Ser Asp Val Asn Asn  Leu Ser Asp 
    1370                 1375                 1380             


Cys Gln  Ala Leu Gly Lys Gln  Ala Arg Trp Lys Asn  Val Lys Val 
    1385                 1390                 1395             


Asn Phe  Asp Asn Val Gly Ala  Gly Tyr Leu Ala Leu  Leu Gln Val 
    1400                 1405                 1410             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1415                 1420                 1425             


Ser Arg  Asp Val Lys Leu Gln  Pro Val Tyr Glu Glu  Asn Leu Tyr 
    1430                 1435                 1440             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1445                 1450                 1455             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1460                 1465                 1470             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1475                 1480                 1485             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1490                 1495                 1500             


Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn Lys Phe  Gln Gly Met 
    1505                 1510                 1515             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1520                 1525                 1530             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1535                 1540                 1545             


Asp Gln  Gly Lys Tyr Met Thr  Leu Val Leu Ser Arg  Ile Asn Leu 
    1550                 1555                 1560             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Phe Val Leu  Lys Leu Val 
    1565                 1570                 1575             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1580                 1585                 1590             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1595                 1600                 1605             


Met Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1610                 1615                 1620             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1625                 1630                 1635             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1640                 1645                 1650             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1655                 1660                 1665             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Lys Glu 
    1670                 1675                 1680             


Ala Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1685                 1690                 1695             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1700                 1705                 1710             


Leu Leu  Ala Pro Ile Leu Asn  Ser Ala Pro Pro Asp  Cys Asp Pro 
    1715                 1720                 1725             


Asp Thr  Ile His Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1730                 1735                 1740             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1745                 1750                 1755             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1760                 1765                 1770             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1775                 1780                 1785             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1790                 1795                 1800             


Ala Thr  Gln Phe Ile Glu Phe  Ser Lys Leu Ser Asp  Phe Ala Ala 
    1805                 1810                 1815             


Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys Pro Asn  Lys Val Gln 
    1820                 1825                 1830             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1835                 1840                 1845             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1850                 1855                 1860             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Asp Arg Phe 
    1865                 1870                 1875             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr 
    1880                 1885                 1890             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Ala  Ile Ile Gln 
    1895                 1900                 1905             


Arg Asn  Phe Arg Cys Tyr Leu  Leu Lys Gln Arg Leu  Lys Asn Ile 
    1910                 1915                 1920             


Ser Ser  Asn Tyr Asn Lys Glu  Ala Ile Lys Gly Arg  Ile Asp Leu 
    1925                 1930                 1935             


Pro Ile  Lys Gln Asp Met Ile  Ile Asp Lys Leu Asn  Gly Asn Ser 
    1940                 1945                 1950             


Thr Pro  Glu Lys Thr Asp Gly  Ser Ser Ser Thr Thr  Ser Pro Pro 
    1955                 1960                 1965             


Ser Tyr  Asp Ser Val Thr Lys  Pro Asp Lys Glu Lys  Phe Glu Lys 
    1970                 1975                 1980             


Asp Lys  Pro Glu Lys Glu Ser  Lys Gly Lys Glu Val  Arg Glu Asn 
    1985                 1990                 1995             


Gln Lys  
    2000 


<210>  24
<211>  1836
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Arg Pro Ser Leu Cys Thr Leu Val Pro Leu Gly Pro Glu Cys 
1               5                   10                  15      


Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
            20                  25                  30          


Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
        35                  40                  45              


Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
    50                  55                  60                  


Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
            100                 105                 110         


Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly Ala Ile Lys Val Leu 
        115                 120                 125             


Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp Ser Lys Asn Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Leu Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Phe Asn 
        275                 280                 285             


Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr Trp Tyr Gly Asn Asp 
    290                 295                 300                 


Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn Asp Ser Trp Tyr Ala 
305                 310                 315                 320 


Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala Thr Asn Asp Thr Phe 
                325                 330                 335     


Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn Phe Tyr Phe Leu Glu 
            340                 345                 350         


Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly His 
        355                 360                 365             


Cys Pro Glu Gly Tyr Glu Cys Ile Lys Thr Gly Arg Asn Pro Asn Tyr 
    370                 375                 380                 


Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe 
385                 390                 395                 400 


Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu 
                405                 410                 415     


Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Ile Ile Phe 
            420                 425                 430         


Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met 
        435                 440                 445             


Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala Glu Asp Lys Glu Lys 
    450                 455                 460                 


Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe Lys Lys His Gln Glu 
465                 470                 475                 480 


Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu Glu Gly Gly Glu Ala 
                485                 490                 495     


Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn Gly Ser Leu Asp Thr 
            500                 505                 510         


Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser Ser Ser Gly Asp Ser 
        515                 520                 525             


Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu Ala His Gln Lys Cys 
    530                 535                 540                 


Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val Leu Ile Trp Asn Cys 
545                 550                 555                 560 


Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile His Leu Ile Val Met 
                565                 570                 575     


Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys Ile Val Leu Asn Thr 
            580                 585                 590         


Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn 
        595                 600                 605             


Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
    610                 615                 620                 


Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln 
625                 630                 635                 640 


Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr Leu Ser Leu Val Glu 
                645                 650                 655     


Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val Leu Arg Ser Phe Arg 
            660                 665                 670         


Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
        675                 680                 685             


Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
    690                 695                 700                 


Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
705                 710                 715                 720 


Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Leu Asp 
                725                 730                 735     


Cys Asn Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu 
            740                 745                 750         


Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
        755                 760                 765             


Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Leu Met 
    770                 775                 780                 


Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
785                 790                 795                 800 


Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp 
                805                 810                 815     


Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly Arg Ile Lys Leu Gly 
            820                 825                 830         


Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu Leu His Gly Lys Ile 
        835                 840                 845             


Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly Glu Ala Asp Gly Ala 
    850                 855                 860                 


Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro Glu Asp Glu Lys Lys 
865                 870                 875                 880 


Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn His Ile Leu Asn His 
                885                 890                 895     


Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu Glu Leu Asp His Leu 
            900                 905                 910         


Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln Val Pro Ile Ala Ser 
        915                 920                 925             


Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu Glu Thr Asp Thr Phe 
    930                 935                 940                 


Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln Pro Leu Tyr Asp Gly 
945                 950                 955                 960 


Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys Pro Pro Glu Glu Asp 
                965                 970                 975     


Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly Glu Gln Pro Glu Glu 
            980                 985                 990         


Cys Phe Thr Glu Ala Cys Val Gln  Arg Trp Pro Cys Leu  Tyr Val Asp 
        995                 1000                 1005             


Ile Ser  Gln Gly Arg Gly Lys  Lys Trp Trp Thr Leu  Arg Arg Ala 
    1010                 1015                 1020             


Cys Phe  Lys Ile Val Glu His  Asn Trp Phe Glu Thr  Phe Ile Val 
    1025                 1030                 1035             


Phe Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1040                 1045                 1050             


Tyr Ile  Glu Gln Arg Arg Val  Ile Arg Thr Ile Leu  Glu Tyr Ala 
    1055                 1060                 1065             


Asp Lys  Val Phe Thr Tyr Ile  Phe Ile Met Glu Met  Leu Leu Lys 
    1070                 1075                 1080             


Trp Val  Ala Tyr Gly Phe Lys  Val Tyr Phe Thr Asn  Ala Trp Cys 
    1085                 1090                 1095             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Ile Ile  Ser Leu Val 
    1100                 1105                 1110             


Ala Asn  Trp Leu Gly Tyr Ser  Glu Leu Gly Pro Ile  Lys Ser Leu 
    1115                 1120                 1125             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1130                 1135                 1140             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Leu Gly  Ala Ile Pro 
    1145                 1150                 1155             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1160                 1165                 1170             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Tyr 
    1175                 1180                 1185             


Cys Ile  Asn Thr Thr Thr Ser  Glu Arg Phe Asp Ile  Ser Glu Val 
    1190                 1195                 1200             


Asn Asn  Lys Ser Glu Cys Glu  Ser Leu Met His Thr  Gly Gln Val 
    1205                 1210                 1215             


Arg Trp  Leu Asn Val Lys Val  Asn Tyr Asp Asn Val  Gly Leu Gly 
    1220                 1225                 1230             


Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp 
    1235                 1240                 1245             


Ile Met  Tyr Ala Ala Val Asp  Ser Arg Glu Lys Glu  Glu Gln Pro 
    1250                 1255                 1260             


Gln Tyr  Glu Val Asn Leu Tyr  Met Tyr Leu Tyr Phe  Val Ile Phe 
    1265                 1270                 1275             


Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val 
    1280                 1285                 1290             


Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Lys 
    1295                 1300                 1305             


Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met 
    1310                 1315                 1320             


Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro 
    1325                 1330                 1335             


Gln Asn  Lys Ile Gln Gly Met  Val Tyr Asp Leu Val  Thr Lys Gln 
    1340                 1345                 1350             


Ala Phe  Asp Ile Thr Ile Met  Ile Leu Ile Cys Leu  Asn Met Val 
    1355                 1360                 1365             


Thr Met  Met Val Glu Thr Asp  Asn Gln Ser Gln Leu  Lys Val Asp 
    1370                 1375                 1380             


Ile Leu  Tyr Asn Ile Asn Met  Ile Phe Ile Ile Ile  Phe Thr Gly 
    1385                 1390                 1395             


Glu Cys  Val Leu Lys Met Leu  Ala Leu Arg Gln Tyr  Tyr Phe Thr 
    1400                 1405                 1410             


Val Gly  Trp Asn Ile Phe Asp  Phe Val Val Val Ile  Leu Ser Ile 
    1415                 1420                 1425             


Val Gly  Leu Ala Leu Ser Asp  Leu Ile Gln Lys Tyr  Phe Val Ser 
    1430                 1435                 1440             


Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala Arg Ile  Gly Arg Val 
    1445                 1450                 1455             


Leu Arg  Leu Ile Arg Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe 
    1460                 1465                 1470             


Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu 
    1475                 1480                 1485             


Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile Phe Gly  Met Ser Asn 
    1490                 1495                 1500             


Phe Ala  Tyr Val Lys Lys Glu  Ser Gly Ile Asp Asp  Met Phe Asn 
    1505                 1510                 1515             


Phe Glu  Thr Phe Gly Asn Ser  Ile Ile Cys Leu Phe  Glu Ile Thr 
    1520                 1525                 1530             


Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Asn Pro Ile  Leu Asn Ser 
    1535                 1540                 1545             


Gly Pro  Pro Asp Cys Asp Pro  Asn Leu Glu Asn Pro  Gly Thr Ser 
    1550                 1555                 1560             


Val Lys  Gly Asp Cys Gly Asn  Pro Ser Ile Gly Ile  Cys Phe Phe 
    1565                 1570                 1575             


Cys Ser  Tyr Ile Ile Ile Ser  Phe Leu Ile Val Val  Asn Met Tyr 
    1580                 1585                 1590             


Ile Ala  Ile Ile Leu Glu Asn  Phe Asn Val Ala Thr  Glu Glu Ser 
    1595                 1600                 1605             


Ser Glu  Pro Leu Gly Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Thr 
    1610                 1615                 1620             


Trp Glu  Lys Phe Asp Pro Asp  Ala Thr Gln Phe Ile  Ala Tyr Ser 
    1625                 1630                 1635             


Arg Leu  Ser Asp Phe Val Asp  Thr Leu Gln Glu Pro  Leu Arg Ile 
    1640                 1645                 1650             


Ala Lys  Pro Asn Lys Ile Lys  Leu Ile Thr Leu Asp  Leu Pro Met 
    1655                 1660                 1665             


Val Pro  Gly Asp Lys Ile His  Cys Leu Asp Ile Leu  Phe Ala Leu 
    1670                 1675                 1680             


Thr Lys  Glu Val Leu Gly Asp  Ser Gly Glu Met Asp  Ala Leu Lys 
    1685                 1690                 1695             


Gln Thr  Met Glu Glu Lys Phe  Met Ala Ala Asn Pro  Ser Lys Val 
    1700                 1705                 1710             


Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys Arg Lys  His Glu Glu 
    1715                 1720                 1725             


Val Cys  Ala Ile Lys Ile Gln  Arg Ala Tyr Arg Arg  His Leu Leu 
    1730                 1735                 1740             


Gln Arg  Ser Met Lys Gln Ala  Ser Tyr Met Tyr Arg  His Ser His 
    1745                 1750                 1755             


Asp Gly  Ser Gly Asp Asp Ala  Pro Glu Lys Glu Gly  Leu Leu Ala 
    1760                 1765                 1770             


Asn Thr  Met Ser Lys Met Tyr  Gly His Glu Asn Gly  Asn Ser Ser 
    1775                 1780                 1785             


Ser Pro  Ser Pro Glu Glu Lys  Gly Glu Ala Gly Asp  Ala Gly Pro 
    1790                 1795                 1800             


Thr Met  Gly Leu Met Pro Ile  Ser Pro Ser Asp Thr  Ala Trp Pro 
    1805                 1810                 1815             


Pro Ala  Pro Pro Pro Gly Gln  Thr Val Arg Pro Gly  Val Lys Glu 
    1820                 1825                 1830             


Ser Leu  Val 
    1835     


<210>  25
<211>  2016
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1640                 1645                 1650             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1655                 1660                 1665             


Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys 
    1670                 1675                 1680             


Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala 
    1685                 1690                 1695             


Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1700                 1705                 1710             


Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys 
    1715                 1720                 1725             


Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly 
    1730                 1735                 1740             


Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile 
    1820                 1825                 1830             


Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys 
    1865                 1870                 1875             


Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His 
    1910                 1915                 1920             


Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu 
    1925                 1930                 1935             


Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser 
    1940                 1945                 1950             


Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile 
    1955                 1960                 1965             


Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala 
    1970                 1975                 1980             


Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser 
    1985                 1990                 1995             


Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu 
    2000                 2005                 2010             


Ser Ile  Val 
    2015     


<210>  26
<211>  1980
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ala Arg Leu Leu Ala Pro Pro Gly Pro Asp Ser Phe Lys Pro 
1               5                   10                  15      


Phe Thr Pro Glu Ser Leu Ala Asn Ile Glu Arg Arg Ile Ala Glu Ser 
            20                  25                  30          


Lys Leu Lys Lys Pro Pro Lys Ala Asp Gly Ser His Arg Glu Asp Asp 
        35                  40                  45              


Glu Asp Ser Lys Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser 
    50                  55                  60                  


Leu Pro Phe Ile Tyr Gly Asp Ile Pro Gln Gly Leu Val Ala Val Pro 
65                  70                  75                  80  


Leu Glu Asp Phe Asp Pro Tyr Tyr Leu Thr Gln Lys Thr Phe Val Val 
                85                  90                  95      


Leu Asn Arg Gly Lys Thr Leu Phe Arg Phe Ser Ala Thr Pro Ala Leu 
            100                 105                 110         


Tyr Ile Leu Ser Pro Phe Asn Leu Ile Arg Arg Ile Ala Ile Lys Ile 
        115                 120                 125             


Leu Ile His Ser Val Phe Ser Met Ile Ile Met Cys Thr Ile Leu Thr 
    130                 135                 140                 


Asn Cys Val Phe Met Thr Phe Ser Asn Pro Pro Asp Trp Ser Lys Asn 
145                 150                 155                 160 


Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys 
                165                 170                 175     


Ile Ile Ala Arg Gly Phe Cys Ile Asp Gly Phe Thr Phe Leu Arg Asp 
            180                 185                 190         


Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Ile Thr 
        195                 200                 205             


Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val 
    210                 215                 220                 


Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile 
225                 230                 235                 240 


Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile 
                245                 250                 255     


Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu 
            260                 265                 270         


Phe Met Gly Asn Leu Arg Asn Lys Cys Val Val Trp Pro Ile Asn Phe 
        275                 280                 285             


Asn Glu Ser Tyr Leu Glu Asn Gly Thr Lys Gly Phe Asp Trp Glu Glu 
    290                 295                 300                 


Tyr Ile Asn Asn Lys Thr Asn Phe Tyr Thr Val Pro Gly Met Leu Glu 
305                 310                 315                 320 


Pro Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly 
                325                 330                 335     


Tyr Gln Cys Met Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser 
            340                 345                 350         


Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr 
        355                 360                 365             


Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly 
    370                 375                 380                 


Lys Thr Tyr Met Ile Phe Phe Val Leu Val Ile Phe Val Gly Ser Phe 
385                 390                 395                 400 


Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu 
                405                 410                 415     


Gln Asn Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe 
            420                 425                 430         


Lys Ala Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala 
        435                 440                 445             


Ala Ala Met Ala Thr Ser Ala Gly Thr Val Ser Glu Asp Ala Ile Glu 
    450                 455                 460                 


Glu Glu Gly Glu Glu Gly Gly Gly Ser Pro Arg Ser Ser Ser Glu Ile 
465                 470                 475                 480 


Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys 
                485                 490                 495     


Lys Arg Lys Gln Lys Glu Leu Ser Glu Gly Glu Glu Lys Gly Asp Pro 
            500                 505                 510         


Glu Lys Val Phe Lys Ser Glu Ser Glu Asp Gly Met Arg Arg Lys Ala 
        515                 520                 525             


Phe Arg Leu Pro Asp Asn Arg Ile Gly Arg Lys Phe Ser Ile Met Asn 
    530                 535                 540                 


Gln Ser Leu Leu Ser Ile Pro Gly Ser Pro Phe Leu Ser Arg His Asn 
545                 550                 555                 560 


Ser Lys Ser Ser Ile Phe Ser Phe Arg Gly Pro Gly Arg Phe Arg Asp 
                565                 570                 575     


Pro Gly Ser Glu Asn Glu Phe Ala Asp Asp Glu His Ser Thr Val Glu 
            580                 585                 590         


Glu Ser Glu Gly Arg Arg Asp Ser Leu Phe Ile Pro Ile Arg Ala Arg 
        595                 600                 605             


Glu Arg Arg Ser Ser Tyr Ser Gly Tyr Ser Gly Tyr Ser Gln Gly Ser 
    610                 615                 620                 


Arg Ser Ser Arg Ile Phe Pro Ser Leu Arg Arg Ser Val Lys Arg Asn 
625                 630                 635                 640 


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Ile Gly Gly Pro Gly 
                645                 650                 655     


Ser His Ile Gly Gly Arg Leu Leu Pro Glu Ala Thr Thr Glu Val Glu 
            660                 665                 670         


Ile Lys Lys Lys Gly Pro Gly Ser Leu Leu Val Ser Met Asp Gln Leu 
        675                 680                 685             


Ala Ser Tyr Gly Arg Lys Asp Arg Ile Asn Ser Ile Met Ser Val Val 
    690                 695                 700                 


Thr Asn Thr Leu Val Glu Glu Leu Glu Glu Ser Gln Arg Lys Cys Pro 
705                 710                 715                 720 


Pro Cys Trp Tyr Lys Phe Ala Asn Thr Phe Leu Ile Trp Glu Cys His 
                725                 730                 735     


Pro Tyr Trp Ile Lys Leu Lys Glu Ile Val Asn Leu Ile Val Met Asp 
            740                 745                 750         


Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu 
        755                 760                 765             


Phe Met Ala Met Glu His His Pro Met Thr Pro Gln Phe Glu His Val 
    770                 775                 780                 


Leu Ala Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met 
785                 790                 795                 800 


Phe Leu Lys Leu Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly 
                805                 810                 815     


Trp Asn Ile Phe Asp Gly Phe Ile Val Ser Leu Ser Leu Met Glu Leu 
            820                 825                 830         


Ser Leu Ala Asp Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu 
        835                 840                 845             


Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu 
    850                 855                 860                 


Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu 
865                 870                 875                 880 


Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu 
                885                 890                 895     


Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Asn Gln Asp Cys 
            900                 905                 910         


Glu Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu Ile 
        915                 920                 925             


Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys 
    930                 935                 940                 


Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val Phe Met Met Val 
945                 950                 955                 960 


Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu 
                965                 970                 975     


Leu Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr Asp Asp Asp Gly 
            980                 985                 990         


Glu Met Asn Asn Leu Gln Ile Ser  Val Ile Arg Ile Lys  Lys Gly Val 
        995                 1000                 1005             


Ala Trp  Thr Lys Leu Lys Val  His Ala Phe Met Gln  Ala His Phe 
    1010                 1015                 1020             


Lys Gln  Arg Glu Ala Asp Glu  Val Lys Pro Leu Asp  Glu Leu Tyr 
    1025                 1030                 1035             


Glu Lys  Lys Ala Asn Cys Ile  Ala Asn His Thr Gly  Ala Asp Ile 
    1040                 1045                 1050             


His Arg  Asn Gly Asp Phe Gln  Lys Asn Gly Asn Gly  Thr Thr Ser 
    1055                 1060                 1065             


Gly Ile  Gly Ser Ser Val Glu  Lys Tyr Ile Ile Asp  Glu Asp His 
    1070                 1075                 1080             


Met Ser  Phe Ile Asn Asn Pro  Asn Leu Thr Val Arg  Val Pro Ile 
    1085                 1090                 1095             


Ala Val  Gly Glu Ser Asp Phe  Glu Asn Leu Asn Thr  Glu Asp Val 
    1100                 1105                 1110             


Ser Ser  Glu Ser Asp Pro Glu  Gly Ser Lys Asp Lys  Leu Asp Asp 
    1115                 1120                 1125             


Thr Ser  Ser Ser Glu Gly Ser  Thr Ile Asp Ile Lys  Pro Glu Val 
    1130                 1135                 1140             


Glu Glu  Val Pro Val Glu Gln  Pro Glu Glu Tyr Leu  Asp Pro Asp 
    1145                 1150                 1155             


Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg Phe Lys  Cys Cys Gln 
    1160                 1165                 1170             


Val Asn  Ile Glu Glu Gly Leu  Gly Lys Ser Trp Trp  Ile Leu Arg 
    1175                 1180                 1185             


Lys Thr  Cys Phe Leu Ile Val  Glu His Asn Trp Phe  Glu Thr Phe 
    1190                 1195                 1200             


Ile Ile  Phe Met Ile Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu 
    1205                 1210                 1215             


Asp Ile  Tyr Ile Glu Gln Arg  Lys Thr Ile Arg Thr  Ile Leu Glu 
    1220                 1225                 1230             


Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu 
    1235                 1240                 1245             


Leu Lys  Trp Thr Ala Tyr Gly  Phe Val Lys Phe Phe  Thr Asn Ala 
    1250                 1255                 1260             


Trp Cys  Trp Leu Asp Phe Leu  Ile Val Ala Val Ser  Leu Val Ser 
    1265                 1270                 1275             


Leu Ile  Ala Asn Ala Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys 
    1280                 1285                 1290             


Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser 
    1295                 1300                 1305             


Arg Phe  Glu Gly Met Arg Val  Val Val Asn Ala Leu  Val Gly Ala 
    1310                 1315                 1320             


Ile Pro  Ser Ile Met Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp 
    1325                 1330                 1335             


Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu Phe Ala  Gly Lys Tyr 
    1340                 1345                 1350             


His Tyr  Cys Phe Asn Glu Thr  Ser Glu Ile Arg Phe  Glu Ile Glu 
    1355                 1360                 1365             


Asp Val  Asn Asn Lys Thr Glu  Cys Glu Lys Leu Met  Glu Gly Asn 
    1370                 1375                 1380             


Asn Thr  Glu Ile Arg Trp Lys  Asn Val Lys Ile Asn  Phe Asp Asn 
    1385                 1390                 1395             


Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln Val Ala  Thr Phe Lys 
    1400                 1405                 1410             


Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val Asp Ser  Arg Lys Pro 
    1415                 1420                 1425             


Asp Glu  Gln Pro Lys Tyr Glu  Asp Asn Ile Tyr Met  Tyr Ile Tyr 
    1430                 1435                 1440             


Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu 
    1445                 1450                 1455             


Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys 
    1460                 1465                 1470             


Phe Gly  Gly Gln Asp Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr 
    1475                 1480                 1485             


Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro 
    1490                 1495                 1500             


Ile Pro  Arg Pro Leu Asn Lys  Ile Gln Gly Ile Val  Phe Asp Phe 
    1505                 1510                 1515             


Val Thr  Gln Gln Ala Phe Asp  Ile Val Ile Met Met  Leu Ile Cys 
    1520                 1525                 1530             


Leu Asn  Met Val Thr Met Met  Val Glu Thr Asp Thr  Gln Ser Lys 
    1535                 1540                 1545             


Gln Met  Glu Asn Ile Leu Tyr  Trp Ile Asn Leu Val  Phe Val Ile 
    1550                 1555                 1560             


Phe Phe  Thr Cys Glu Cys Val  Leu Lys Met Phe Ala  Leu Arg His 
    1565                 1570                 1575             


Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe Asp Phe  Val Val Val 
    1580                 1585                 1590             


Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala Asp Ile  Ile Glu Lys 
    1595                 1600                 1605             


Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg 
    1610                 1615                 1620             


Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg 
    1625                 1630                 1635             


Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn 
    1640                 1645                 1650             


Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe Ile Phe  Ser Ile Phe 
    1655                 1660                 1665             


Gly Met  Ser Asn Phe Ala Tyr  Val Lys His Glu Ala  Gly Ile Asp 
    1670                 1675                 1680             


Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu 
    1685                 1690                 1695             


Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp Gly Leu  Leu Leu Pro 
    1700                 1705                 1710             


Ile Leu  Asn Arg Pro Pro Asp  Cys Ser Leu Asp Lys  Glu His Pro 
    1715                 1720                 1725             


Gly Ser  Gly Phe Lys Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile 
    1730                 1735                 1740             


Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser Phe Leu  Ile Val Val 
    1745                 1750                 1755             


Asn Met  Tyr Ile Ala Ile Ile  Leu Glu Asn Phe Ser  Val Ala Thr 
    1760                 1765                 1770             


Glu Glu  Ser Ala Asp Pro Leu  Ser Glu Asp Asp Phe  Glu Thr Phe 
    1775                 1780                 1785             


Tyr Glu  Ile Trp Glu Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile 
    1790                 1795                 1800             


Glu Tyr  Cys Lys Leu Ala Asp  Phe Ala Asp Ala Leu  Glu His Pro 
    1805                 1810                 1815             


Leu Arg  Val Pro Lys Pro Asn  Thr Ile Glu Leu Ile  Ala Met Asp 
    1820                 1825                 1830             


Leu Pro  Met Val Ser Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu 
    1835                 1840                 1845             


Phe Ala  Phe Thr Lys Arg Val  Leu Gly Asp Ser Gly  Glu Leu Asp 
    1850                 1855                 1860             


Ile Leu  Arg Gln Gln Met Glu  Glu Arg Phe Val Ala  Ser Asn Pro 
    1865                 1870                 1875             


Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr Thr Leu  Arg Arg Lys 
    1880                 1885                 1890             


Gln Glu  Glu Val Ser Ala Val  Val Leu Gln Arg Ala  Tyr Arg Gly 
    1895                 1900                 1905             


His Leu  Ala Arg Arg Gly Phe  Ile Cys Lys Lys Thr  Thr Ser Asn 
    1910                 1915                 1920             


Lys Leu  Glu Asn Gly Gly Thr  His Arg Glu Lys Lys  Glu Ser Thr 
    1925                 1930                 1935             


Pro Ser  Thr Ala Ser Leu Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Glu Lys  Glu Lys Gln Gln Arg  Ala Glu Glu Gly Arg  Arg Glu Arg 
    1955                 1960                 1965             


Ala Lys  Arg Gln Lys Glu Val  Arg Glu Ser Lys Cys  
    1970                 1975                 1980 


<210>  27
<211>  1988
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp 
                645                 650                 655     


Asp Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys 
                725                 730                 735     


Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
            740                 745                 750         


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met 
        755                 760                 765             


Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr 
    770                 775                 780                 


Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro 
785                 790                 795                 800 


Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 
                805                 810                 815     


Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 
            820                 825                 830         


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
        835                 840                 845             


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
    850                 855                 860                 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
865                 870                 875                 880 


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
                885                 890                 895     


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
            900                 905                 910         


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
        915                 920                 925             


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 
    930                 935                 940                 


Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
945                 950                 955                 960 


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
                965                 970                 975     


Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn Leu Gln Ile Ala Val 
            980                 985                 990         


Thr Arg Ile Lys Lys Gly Ile Asn  Tyr Val Lys Gln Thr  Leu Arg Glu 
        995                 1000                 1005             


Phe Ile  Leu Lys Ala Phe Ser  Lys Lys Pro Lys Ile  Ser Arg Glu 
    1010                 1015                 1020             


Ile Arg  Gln Ala Glu Asp Leu  Asn Thr Lys Lys Glu  Asn Tyr Ile 
    1025                 1030                 1035             


Ser Asn  His Thr Leu Ala Glu  Met Ser Lys Gly His  Asn Phe Leu 
    1040                 1045                 1050             


Lys Glu  Lys Asp Lys Ile Ser  Gly Phe Gly Ser Ser  Val Asp Lys 
    1055                 1060                 1065             


His Leu  Met Glu Asp Ser Asp  Gly Gln Ser Phe Ile  His Asn Pro 
    1070                 1075                 1080             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu 
    1085                 1090                 1095             


Glu Asn  Met Asn Ala Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu 
    1100                 1105                 1110             


Tyr Ser  Lys Val Arg Leu Asn  Arg Ser Ser Ser Ser  Glu Cys Ser 
    1115                 1120                 1125             


Thr Val  Asp Asn Pro Leu Pro  Gly Glu Gly Glu Glu  Ala Glu Ala 
    1130                 1135                 1140             


Glu Pro  Met Asn Ser Asp Glu  Pro Glu Ala Cys Phe  Thr Asp Gly 
    1145                 1150                 1155             


Cys Val  Trp Arg Phe Ser Cys  Cys Gln Val Asn Ile  Glu Ser Gly 
    1160                 1165                 1170             


Lys Gly  Lys Ile Trp Trp Asn  Ile Arg Lys Thr Cys  Tyr Lys Ile 
    1175                 1180                 1185             


Val Glu  His Ser Trp Phe Glu  Ser Phe Ile Val Leu  Met Ile Leu 
    1190                 1195                 1200             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Arg 
    1205                 1210                 1215             


Lys Lys  Thr Ile Lys Ile Ile  Leu Glu Tyr Ala Asp  Lys Ile Phe 
    1220                 1225                 1230             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Ile Ala Tyr 
    1235                 1240                 1245             


Gly Tyr  Lys Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1250                 1255                 1260             


Leu Ile  Val Asp Val Ser Leu  Val Thr Leu Val Ala  Asn Thr Leu 
    1265                 1270                 1275             


Gly Tyr  Ser Asp Leu Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1280                 1285                 1290             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1295                 1300                 1305             


Val Val  Val Asn Ala Leu Ile  Gly Ala Ile Pro Ser  Ile Met Asn 
    1310                 1315                 1320             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1325                 1330                 1335             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr Glu Cys  Ile Asn Thr 
    1340                 1345                 1350             


Thr Asp  Gly Ser Arg Phe Pro  Ala Ser Gln Val Pro  Asn Arg Ser 
    1355                 1360                 1365             


Glu Cys  Phe Ala Leu Met Asn  Val Ser Gln Asn Val  Arg Trp Lys 
    1370                 1375                 1380             


Asn Leu  Lys Val Asn Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser 
    1385                 1390                 1395             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Thr Ile  Ile Met Tyr 
    1400                 1405                 1410             


Ala Ala  Val Asp Ser Val Asn  Val Asp Lys Gln Pro  Lys Tyr Glu 
    1415                 1420                 1425             


Tyr Ser  Leu Tyr Met Tyr Ile  Tyr Phe Val Val Phe  Ile Ile Phe 
    1430                 1435                 1440             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1445                 1450                 1455             


Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe 
    1460                 1465                 1470             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1475                 1480                 1485             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1490                 1495                 1500             


Ile Gln  Gly Cys Ile Phe Asp  Leu Val Thr Asn Gln  Ala Phe Asp 
    1505                 1510                 1515             


Ile Ser  Ile Met Val Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1520                 1525                 1530             


Val Glu  Lys Glu Gly Gln Ser  Gln His Met Thr Glu  Val Leu Tyr 
    1535                 1540                 1545             


Trp Ile  Asn Val Val Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val 
    1550                 1555                 1560             


Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr Phe Thr  Val Gly Trp 
    1565                 1570                 1575             


Asn Ile  Phe Asp Phe Val Val  Val Ile Ile Ser Ile  Val Gly Met 
    1580                 1585                 1590             


Phe Leu  Ala Asp Leu Ile Glu  Thr Tyr Phe Val Ser  Pro Thr Leu 
    1595                 1600                 1605             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1610                 1615                 1620             


Val Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1625                 1630                 1635             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1640                 1645                 1650             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1655                 1660                 1665             


Val Lys  Lys Glu Asp Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr 
    1670                 1675                 1680             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1685                 1690                 1695             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro 
    1700                 1705                 1710             


Asp Cys  Asp Pro Lys Lys Val  His Pro Gly Ser Ser  Val Glu Gly 
    1715                 1720                 1725             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr 
    1730                 1735                 1740             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1745                 1750                 1755             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1760                 1765                 1770             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1775                 1780                 1785             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Phe Ser  Lys Leu Ser 
    1790                 1795                 1800             


Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1805                 1810                 1815             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1820                 1825                 1830             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1835                 1840                 1845             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met 
    1850                 1855                 1860             


Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1865                 1870                 1875             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala 
    1880                 1885                 1890             


Thr Val  Ile Gln Arg Ala Tyr  Arg Arg Tyr Arg Leu  Arg Gln Asn 
    1895                 1900                 1905             


Val Lys  Asn Ile Ser Ser Ile  Tyr Ile Lys Asp Gly  Asp Arg Asp 
    1910                 1915                 1920             


Asp Asp  Leu Leu Asn Lys Lys  Asp Met Ala Phe Asp  Asn Val Asn 
    1925                 1930                 1935             


Glu Asn  Ser Ser Pro Glu Lys  Thr Asp Ala Thr Ser  Ser Thr Thr 
    1940                 1945                 1950             


Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Lys Pro Asp  Lys Glu Lys 
    1955                 1960                 1965             


Tyr Glu  Gln Asp Arg Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Ser 
    1970                 1975                 1980             


Lys Glu  Ser Lys Lys 
    1985             


<210>  28
<211>  1988
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp 
                645                 650                 655     


Asp Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys 
                725                 730                 735     


Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
            740                 745                 750         


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met 
        755                 760                 765             


Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr 
    770                 775                 780                 


Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro 
785                 790                 795                 800 


Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 
                805                 810                 815     


Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 
            820                 825                 830         


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
        835                 840                 845             


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
    850                 855                 860                 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
865                 870                 875                 880 


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
                885                 890                 895     


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
            900                 905                 910         


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
        915                 920                 925             


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 
    930                 935                 940                 


Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
945                 950                 955                 960 


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
                965                 970                 975     


Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn Leu Gln Ile Ala Val 
            980                 985                 990         


Thr Arg Ile Lys Lys Gly Ile Asn  Tyr Val Lys Gln Thr  Leu Arg Glu 
        995                 1000                 1005             


Phe Ile  Leu Lys Ala Phe Ser  Lys Lys Pro Lys Ile  Ser Arg Glu 
    1010                 1015                 1020             


Ile Arg  Gln Ala Glu Asp Leu  Asn Thr Lys Lys Glu  Asn Tyr Ile 
    1025                 1030                 1035             


Ser Asn  His Thr Leu Ala Glu  Met Ser Lys Gly His  Asn Phe Leu 
    1040                 1045                 1050             


Lys Glu  Lys Asp Lys Ile Ser  Gly Phe Gly Ser Ser  Val Asp Lys 
    1055                 1060                 1065             


His Leu  Met Glu Asp Ser Asp  Gly Gln Ser Phe Ile  His Asn Pro 
    1070                 1075                 1080             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu 
    1085                 1090                 1095             


Glu Asn  Met Asn Ala Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu 
    1100                 1105                 1110             


Tyr Ser  Lys Val Arg Leu Asn  Arg Ser Ser Ser Ser  Glu Cys Ser 
    1115                 1120                 1125             


Thr Val  Asp Asn Pro Leu Pro  Gly Glu Gly Glu Glu  Ala Glu Ala 
    1130                 1135                 1140             


Glu Pro  Met Asn Ser Asp Glu  Pro Glu Ala Cys Phe  Thr Asp Gly 
    1145                 1150                 1155             


Cys Val  Trp Arg Phe Ser Cys  Cys Gln Val Asn Ile  Glu Ser Gly 
    1160                 1165                 1170             


Lys Gly  Lys Ile Trp Trp Asn  Ile Arg Lys Thr Cys  Tyr Lys Ile 
    1175                 1180                 1185             


Val Glu  His Ser Trp Phe Glu  Ser Phe Ile Val Leu  Met Ile Leu 
    1190                 1195                 1200             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Arg 
    1205                 1210                 1215             


Lys Lys  Thr Ile Lys Ile Ile  Leu Glu Tyr Ala Asp  Lys Ile Phe 
    1220                 1225                 1230             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Ile Ala Tyr 
    1235                 1240                 1245             


Gly Tyr  Lys Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1250                 1255                 1260             


Leu Ile  Val Asp Val Ser Leu  Val Thr Leu Val Ala  Asn Thr Leu 
    1265                 1270                 1275             


Gly Tyr  Ser Asp Leu Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1280                 1285                 1290             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1295                 1300                 1305             


Val Val  Val Asn Ala Leu Ile  Gly Ala Ile Pro Ser  Ile Met Asn 
    1310                 1315                 1320             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1325                 1330                 1335             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr Glu Cys  Ile Asn Thr 
    1340                 1345                 1350             


Thr Asp  Gly Ser Arg Phe Pro  Ala Ser Gln Val Pro  Asn Arg Ser 
    1355                 1360                 1365             


Glu Cys  Phe Ala Leu Met Asn  Val Ser Gln Asn Val  Arg Trp Lys 
    1370                 1375                 1380             


Asn Leu  Lys Val Asn Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser 
    1385                 1390                 1395             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Thr Ile  Ile Met Tyr 
    1400                 1405                 1410             


Ala Ala  Val Asp Ser Val Asn  Val Asp Lys Gln Pro  Lys Tyr Glu 
    1415                 1420                 1425             


Tyr Ser  Leu Tyr Met Tyr Ile  Tyr Phe Val Val Phe  Ile Ile Phe 
    1430                 1435                 1440             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1445                 1450                 1455             


Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe 
    1460                 1465                 1470             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1475                 1480                 1485             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1490                 1495                 1500             


Ile Gln  Gly Cys Ile Phe Asp  Leu Val Thr Asn Gln  Ala Phe Asp 
    1505                 1510                 1515             


Ile Ser  Ile Met Val Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1520                 1525                 1530             


Val Glu  Lys Glu Gly Gln Ser  Gln His Met Thr Glu  Val Leu Tyr 
    1535                 1540                 1545             


Trp Ile  Asn Val Val Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val 
    1550                 1555                 1560             


Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr Phe Thr  Val Gly Trp 
    1565                 1570                 1575             


Asn Ile  Phe Asp Phe Val Val  Val Ile Ile Ser Ile  Val Gly Met 
    1580                 1585                 1590             


Phe Leu  Ala Asp Leu Ile Glu  Thr Tyr Phe Val Ser  Pro Thr Leu 
    1595                 1600                 1605             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1610                 1615                 1620             


Val Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1625                 1630                 1635             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1640                 1645                 1650             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1655                 1660                 1665             


Val Lys  Lys Glu Asp Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr 
    1670                 1675                 1680             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1685                 1690                 1695             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro 
    1700                 1705                 1710             


Asp Cys  Asp Pro Lys Lys Val  His Pro Gly Ser Ser  Val Glu Gly 
    1715                 1720                 1725             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr 
    1730                 1735                 1740             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1745                 1750                 1755             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1760                 1765                 1770             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1775                 1780                 1785             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Phe Ser  Lys Leu Ser 
    1790                 1795                 1800             


Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1805                 1810                 1815             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1820                 1825                 1830             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1835                 1840                 1845             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met 
    1850                 1855                 1860             


Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1865                 1870                 1875             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala 
    1880                 1885                 1890             


Thr Val  Ile Gln Arg Ala Tyr  Arg Arg Tyr Arg Leu  Arg Gln Asn 
    1895                 1900                 1905             


Val Lys  Asn Ile Ser Ser Ile  Tyr Ile Lys Asp Gly  Asp Arg Asp 
    1910                 1915                 1920             


Asp Asp  Leu Leu Asn Lys Lys  Asp Met Ala Phe Asp  Asn Val Asn 
    1925                 1930                 1935             


Glu Asn  Ser Ser Pro Glu Lys  Thr Asp Ala Thr Ser  Ser Thr Thr 
    1940                 1945                 1950             


Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Lys Pro Asp  Lys Glu Lys 
    1955                 1960                 1965             


Tyr Glu  Gln Asp Arg Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Ser 
    1970                 1975                 1980             


Lys Glu  Ser Lys Lys 
    1985             


<210>  29
<211>  1791
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Asp Asp Arg Cys Tyr Pro Val Ile Phe Pro Asp Glu Arg Asn Phe 
1               5                   10                  15      


Arg Pro Phe Thr Ser Asp Ser Leu Ala Ala Ile Glu Lys Arg Ile Ala 
            20                  25                  30          


Ile Gln Lys Glu Lys Lys Lys Ser Lys Asp Gln Thr Gly Glu Val Pro 
        35                  40                  45              


Gln Pro Arg Pro Gln Leu Asp Leu Lys Ala Ser Arg Lys Leu Pro Lys 
    50                  55                  60                  


Leu Tyr Gly Asp Ile Pro Arg Glu Leu Ile Gly Lys Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Phe Tyr Arg Asn His Lys Thr Phe Met Val Leu Asn Arg 
                85                  90                  95      


Lys Arg Thr Ile Tyr Arg Phe Ser Ala Lys His Ala Leu Phe Ile Phe 
            100                 105                 110         


Gly Pro Phe Asn Ser Ile Arg Ser Leu Ala Ile Arg Val Ser Val His 
        115                 120                 125             


Ser Leu Phe Ser Met Phe Ile Ile Gly Thr Val Ile Ile Asn Cys Val 
    130                 135                 140                 


Phe Met Ala Thr Gly Pro Ala Lys Asn Ser Asn Ser Asn Asn Thr Asp 
145                 150                 155                 160 


Ile Ala Glu Cys Val Phe Thr Gly Ile Tyr Ile Phe Glu Ala Leu Ile 
                165                 170                 175     


Lys Ile Leu Ala Arg Gly Phe Ile Leu Asp Glu Phe Ser Phe Leu Arg 
            180                 185                 190         


Asp Pro Trp Asn Trp Leu Asp Ser Ile Val Ile Gly Ile Ala Ile Val 
        195                 200                 205             


Ser Tyr Ile Pro Gly Ile Thr Ile Lys Leu Leu Pro Leu Arg Thr Phe 
    210                 215                 220                 


Arg Val Phe Arg Ala Leu Lys Ala Ile Ser Val Val Ser Arg Leu Lys 
225                 230                 235                 240 


Val Ile Val Gly Ala Leu Leu Arg Ser Val Lys Lys Leu Val Asn Val 
                245                 250                 255     


Ile Ile Leu Thr Phe Phe Cys Leu Ser Ile Phe Ala Leu Val Gly Gln 
            260                 265                 270         


Gln Leu Phe Met Gly Ser Leu Asn Leu Lys Cys Ile Ser Arg Asp Cys 
        275                 280                 285             


Lys Asn Ile Ser Asn Pro Glu Ala Tyr Asp His Cys Phe Glu Lys Lys 
    290                 295                 300                 


Glu Asn Ser Pro Glu Phe Lys Met Cys Gly Ile Trp Met Gly Asn Ser 
305                 310                 315                 320 


Ala Cys Ser Ile Gln Tyr Glu Cys Lys His Thr Lys Ile Asn Pro Asp 
                325                 330                 335     


Tyr Asn Tyr Thr Asn Phe Asp Asn Phe Gly Trp Ser Phe Leu Ala Met 
            340                 345                 350         


Phe Arg Leu Met Thr Gln Asp Ser Trp Glu Lys Leu Tyr Gln Gln Thr 
        355                 360                 365             


Leu Arg Thr Thr Gly Leu Tyr Ser Val Phe Phe Phe Ile Val Val Ile 
    370                 375                 380                 


Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Thr Leu Ala Val Val Thr 
385                 390                 395                 400 


Met Ala Tyr Glu Glu Gln Asn Lys Asn Val Ala Ala Glu Ile Glu Ala 
                405                 410                 415     


Lys Glu Lys Met Phe Gln Glu Ala Gln Gln Leu Leu Lys Glu Glu Lys 
            420                 425                 430         


Glu Ala Leu Val Ala Met Gly Ile Asp Arg Ser Ser Leu Thr Ser Leu 
        435                 440                 445             


Glu Thr Ser Tyr Phe Thr Pro Lys Lys Arg Lys Leu Phe Gly Asn Lys 
    450                 455                 460                 


Lys Arg Lys Ser Phe Phe Leu Arg Glu Ser Gly Lys Asp Gln Pro Pro 
465                 470                 475                 480 


Gly Ser Asp Ser Asp Glu Asp Cys Gln Lys Lys Pro Gln Leu Leu Glu 
                485                 490                 495     


Gln Thr Lys Arg Leu Ser Gln Asn Leu Ser Leu Asp His Phe Asp Glu 
            500                 505                 510         


His Gly Asp Pro Leu Gln Arg Gln Arg Ala Leu Ser Ala Val Ser Ile 
        515                 520                 525             


Leu Thr Ile Thr Met Lys Glu Gln Glu Lys Ser Gln Glu Pro Cys Leu 
    530                 535                 540                 


Pro Cys Gly Glu Asn Leu Ala Ser Lys Tyr Leu Val Trp Asn Cys Cys 
545                 550                 555                 560 


Pro Gln Trp Leu Cys Val Lys Lys Val Leu Arg Thr Val Met Thr Asp 
                565                 570                 575     


Pro Phe Thr Glu Leu Ala Ile Thr Ile Cys Ile Ile Ile Asn Thr Val 
            580                 585                 590         


Phe Leu Ala Met Glu His His Lys Met Glu Ala Ser Phe Glu Lys Met 
        595                 600                 605             


Leu Asn Ile Gly Asn Leu Val Phe Thr Ser Ile Phe Ile Ala Glu Met 
    610                 615                 620                 


Cys Leu Lys Ile Ile Ala Leu Asp Pro Tyr His Tyr Phe Arg Arg Gly 
625                 630                 635                 640 


Trp Asn Ile Phe Asp Ser Ile Val Ala Leu Leu Ser Phe Ala Asp Val 
                645                 650                 655     


Met Asn Cys Val Leu Gln Lys Arg Ser Trp Pro Phe Leu Arg Ser Phe 
            660                 665                 670         


Arg Val Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn 
        675                 680                 685             


Thr Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Ser Leu 
    690                 695                 700                 


Thr Val Val Leu Val Ile Val Ile Phe Ile Phe Ser Val Val Gly Met 
705                 710                 715                 720 


Gln Leu Phe Gly Arg Ser Phe Asn Ser Gln Lys Ser Pro Lys Leu Cys 
                725                 730                 735     


Asn Pro Thr Gly Pro Thr Val Ser Cys Leu Arg His Trp His Met Gly 
            740                 745                 750         


Asp Phe Trp His Ser Phe Leu Val Val Phe Arg Ile Leu Cys Gly Glu 
        755                 760                 765             


Trp Ile Glu Asn Met Trp Glu Cys Met Gln Glu Ala Asn Ala Ser Ser 
    770                 775                 780                 


Ser Leu Cys Val Ile Val Phe Ile Leu Ile Thr Val Ile Gly Lys Leu 
785                 790                 795                 800 


Val Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Asn 
                805                 810                 815     


Glu Glu Arg Asn Gly Asn Leu Glu Gly Glu Ala Arg Lys Thr Lys Val 
            820                 825                 830         


Gln Leu Ala Leu Asp Arg Phe Arg Arg Ala Phe Cys Phe Val Arg His 
        835                 840                 845             


Thr Leu Glu His Phe Cys His Lys Trp Cys Arg Lys Gln Asn Leu Pro 
    850                 855                 860                 


Gln Gln Lys Glu Val Ala Gly Gly Cys Ala Ala Gln Ser Lys Asp Ile 
865                 870                 875                 880 


Ile Pro Leu Val Met Glu Met Lys Arg Gly Ser Glu Thr Gln Glu Glu 
                885                 890                 895     


Leu Gly Ile Leu Thr Ser Val Pro Lys Thr Leu Gly Val Arg His Asp 
            900                 905                 910         


Trp Thr Trp Leu Ala Pro Leu Ala Glu Glu Glu Asp Asp Val Glu Phe 
        915                 920                 925             


Ser Gly Glu Asp Asn Ala Gln Arg Ile Thr Gln Pro Glu Pro Glu Gln 
    930                 935                 940                 


Gln Ala Tyr Glu Leu His Gln Glu Asn Lys Lys Pro Thr Ser Gln Arg 
945                 950                 955                 960 


Val Gln Ser Val Glu Ile Asp Met Phe Ser Glu Asp Glu Pro His Leu 
                965                 970                 975     


Thr Ile Gln Asp Pro Arg Lys Lys Ser Asp Val Thr Ser Ile Leu Ser 
            980                 985                 990         


Glu Cys Ser Thr Ile Asp Leu Gln  Asp Gly Phe Gly Trp  Leu Pro Glu 
        995                 1000                 1005             


Met Val  Pro Lys Lys Gln Pro  Glu Arg Cys Leu Pro  Lys Gly Phe 
    1010                 1015                 1020             


Gly Cys  Cys Phe Pro Cys Cys  Ser Val Asp Lys Arg  Lys Pro Pro 
    1025                 1030                 1035             


Trp Val  Ile Trp Trp Asn Leu  Arg Lys Thr Cys Tyr  Gln Ile Val 
    1040                 1045                 1050             


Lys His  Ser Trp Phe Glu Ser  Phe Ile Ile Phe Val  Ile Leu Leu 
    1055                 1060                 1065             


Ser Ser  Gly Ala Leu Ile Phe  Glu Asp Val His Leu  Glu Asn Gln 
    1070                 1075                 1080             


Pro Lys  Ile Gln Glu Leu Leu  Asn Cys Thr Asp Ile  Ile Phe Thr 
    1085                 1090                 1095             


His Ile  Phe Ile Leu Glu Met  Val Leu Lys Trp Val  Ala Phe Gly 
    1100                 1105                 1110             


Phe Gly  Lys Tyr Phe Thr Ser  Ala Trp Cys Cys Leu  Asp Phe Ile 
    1115                 1120                 1125             


Ile Val  Ile Val Ser Val Thr  Thr Leu Ile Asn Leu  Met Glu Leu 
    1130                 1135                 1140             


Lys Ser  Phe Arg Thr Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu 
    1145                 1150                 1155             


Ser Gln  Phe Glu Gly Met Lys  Val Val Val Asn Ala  Leu Ile Gly 
    1160                 1165                 1170             


Ala Ile  Pro Ala Ile Leu Asn  Val Leu Leu Val Cys  Leu Ile Phe 
    1175                 1180                 1185             


Trp Leu  Val Phe Cys Ile Leu  Gly Val Tyr Phe Phe  Ser Gly Lys 
    1190                 1195                 1200             


Phe Gly  Lys Cys Ile Asn Gly  Thr Asp Ser Val Ile  Asn Tyr Thr 
    1205                 1210                 1215             


Ile Ile  Thr Asn Lys Ser Gln  Cys Glu Ser Gly Asn  Phe Ser Trp 
    1220                 1225                 1230             


Ile Asn  Gln Lys Val Asn Phe  Asp Asn Val Gly Asn  Ala Tyr Leu 
    1235                 1240                 1245             


Ala Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Ile 
    1250                 1255                 1260             


Tyr Ala  Ala Val Asp Ser Thr  Glu Lys Glu Gln Gln  Pro Glu Phe 
    1265                 1270                 1275             


Glu Ser  Asn Ser Leu Gly Tyr  Ile Tyr Phe Val Val  Phe Ile Ile 
    1280                 1285                 1290             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1295                 1300                 1305             


Asp Asn  Phe Asn Gln Gln Gln  Lys Lys Leu Gly Gly  Gln Asp Ile 
    1310                 1315                 1320             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1325                 1330                 1335             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Leu Asn 
    1340                 1345                 1350             


Lys Cys  Gln Gly Leu Val Phe  Asp Ile Val Thr Ser  Gln Ile Phe 
    1355                 1360                 1365             


Asp Ile  Ile Ile Ile Ser Leu  Ile Ile Leu Asn Met  Ile Ser Met 
    1370                 1375                 1380             


Met Ala  Glu Ser Tyr Asn Gln  Pro Lys Ala Met Lys  Ser Ile Leu 
    1385                 1390                 1395             


Asp His  Leu Asn Trp Val Phe  Val Val Ile Phe Thr  Leu Glu Cys 
    1400                 1405                 1410             


Leu Ile  Lys Ile Phe Ala Leu  Arg Gln Tyr Tyr Phe  Thr Asn Gly 
    1415                 1420                 1425             


Trp Asn  Leu Phe Asp Cys Val  Val Val Leu Leu Ser  Ile Val Ser 
    1430                 1435                 1440             


Thr Met  Ile Ser Thr Leu Glu  Asn Gln Glu His Ile  Pro Phe Pro 
    1445                 1450                 1455             


Pro Thr  Leu Phe Arg Ile Val  Arg Leu Ala Arg Ile  Gly Arg Ile 
    1460                 1465                 1470             


Leu Arg  Leu Val Arg Ala Ala  Arg Gly Ile Arg Thr  Leu Leu Phe 
    1475                 1480                 1485             


Ala Leu  Met Met Ser Leu Pro  Ser Leu Phe Asn Ile  Gly Leu Leu 
    1490                 1495                 1500             


Leu Phe  Leu Ile Met Phe Ile  Tyr Ala Ile Leu Gly  Met Asn Trp 
    1505                 1510                 1515             


Phe Ser  Lys Val Asn Pro Glu  Ser Gly Ile Asp Asp  Ile Phe Asn 
    1520                 1525                 1530             


Phe Lys  Thr Phe Ala Ser Ser  Met Leu Cys Leu Phe  Gln Ile Ser 
    1535                 1540                 1545             


Thr Ser  Ala Gly Trp Asp Ser  Leu Leu Ser Pro Met  Leu Arg Ser 
    1550                 1555                 1560             


Lys Glu  Ser Cys Asn Ser Ser  Ser Glu Asn Cys His  Leu Pro Gly 
    1565                 1570                 1575             


Ile Ala  Thr Ser Tyr Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu 
    1580                 1585                 1590             


Ile Val  Val Asn Met Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Asn 
    1595                 1600                 1605             


Thr Ala  Thr Glu Glu Ser Glu  Asp Pro Leu Gly Glu  Asp Asp Phe 
    1610                 1615                 1620             


Asp Ile  Phe Tyr Glu Val Trp  Glu Lys Phe Asp Pro  Glu Ala Thr 
    1625                 1630                 1635             


Gln Phe  Ile Lys Tyr Ser Ala  Leu Ser Asp Phe Ala  Asp Ala Leu 
    1640                 1645                 1650             


Pro Glu  Pro Leu Arg Val Ala  Lys Pro Asn Lys Tyr  Gln Phe Leu 
    1655                 1660                 1665             


Val Met  Asp Leu Pro Met Val  Ser Glu Asp Arg Leu  His Cys Met 
    1670                 1675                 1680             


Asp Ile  Leu Phe Ala Phe Thr  Ala Arg Val Leu Gly  Gly Ser Asp 
    1685                 1690                 1695             


Gly Leu  Asp Ser Met Lys Ala  Met Met Glu Glu Lys  Phe Met Glu 
    1700                 1705                 1710             


Ala Asn  Pro Leu Lys Lys Leu  Tyr Glu Pro Ile Val  Thr Thr Thr 
    1715                 1720                 1725             


Lys Arg  Lys Glu Glu Glu Arg  Gly Ala Ala Ile Ile  Gln Lys Ala 
    1730                 1735                 1740             


Phe Arg  Lys Tyr Met Met Lys  Val Thr Lys Gly Asp  Gln Gly Asp 
    1745                 1750                 1755             


Gln Asn  Asp Leu Glu Asn Gly  Pro His Ser Pro Leu  Gln Thr Leu 
    1760                 1765                 1770             


Cys Asn  Gly Asp Leu Ser Ser  Phe Gly Val Ala Lys  Gly Lys Val 
    1775                 1780                 1785             


His Cys  Asp 
    1790     


<210>  30
<211>  1791
<212>  PRT
<213>  Pan troglodytes

<400>  30

Met Asp Asp Arg Cys Tyr Pro Val Ile Phe Pro Asp Glu Arg Asn Phe 
1               5                   10                  15      


Arg Pro Phe Thr Ser Asp Ser Leu Ala Ala Ile Glu Lys Arg Ile Ala 
            20                  25                  30          


Ile Gln Lys Glu Lys Lys Lys Ser Lys Asp Gln Thr Gly Glu Val Pro 
        35                  40                  45              


Gln Pro Arg Pro Gln Leu Asp Leu Lys Ala Ser Arg Lys Leu Pro Lys 
    50                  55                  60                  


Leu Tyr Gly Asp Ile Pro Arg Glu Leu Ile Gly Lys Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Phe Tyr Arg Asn His Lys Thr Phe Met Val Leu Asn Arg 
                85                  90                  95      


Lys Arg Thr Ile Tyr Arg Phe Ser Ala Lys His Ala Leu Phe Ile Phe 
            100                 105                 110         


Gly Pro Phe Asn Ser Ile Arg Ser Leu Ala Ile Arg Val Ser Val His 
        115                 120                 125             


Ser Leu Phe Ser Met Phe Ile Ile Gly Thr Val Ile Ile Asn Cys Val 
    130                 135                 140                 


Phe Met Ala Thr Gly Pro Ala Lys Asn Ser Asn Ser Asn Asn Thr Asp 
145                 150                 155                 160 


Ile Ala Glu Cys Val Phe Thr Gly Ile Tyr Ile Phe Glu Ala Leu Ile 
                165                 170                 175     


Lys Ile Leu Ala Arg Gly Phe Ile Leu Asp Glu Phe Ser Phe Leu Arg 
            180                 185                 190         


Asp Pro Trp Asn Trp Leu Asp Ser Ile Val Ile Gly Ile Ala Ile Val 
        195                 200                 205             


Ser Tyr Ile Pro Gly Ile Thr Ile Lys Leu Leu Pro Leu Arg Thr Phe 
    210                 215                 220                 


Arg Val Phe Arg Ala Leu Lys Ala Ile Ser Val Val Ser Arg Leu Lys 
225                 230                 235                 240 


Val Ile Val Gly Ala Leu Leu Arg Ser Val Lys Lys Leu Val Asn Val 
                245                 250                 255     


Ile Ile Leu Thr Phe Phe Cys Leu Ser Ile Phe Ala Leu Val Gly Gln 
            260                 265                 270         


Gln Leu Phe Met Gly Ser Leu Asn Leu Lys Cys Ile Ser Arg Asp Cys 
        275                 280                 285             


Lys Asn Ile Ser Asn Pro Glu Ala Tyr Asp His Cys Phe Glu Lys Lys 
    290                 295                 300                 


Glu Asn Ser Pro Glu Phe Lys Met Cys Gly Ile Trp Met Gly Asn Ser 
305                 310                 315                 320 


Ala Cys Ser Ile Gln Tyr Glu Cys Lys His Thr Lys Ile Asn Pro Asp 
                325                 330                 335     


Tyr Asn Tyr Thr Asn Phe Asp Asn Phe Gly Trp Ser Phe Leu Ala Met 
            340                 345                 350         


Phe Arg Leu Met Thr Gln Asp Ser Trp Glu Lys Leu Tyr Gln Gln Thr 
        355                 360                 365             


Leu Arg Thr Thr Gly Leu Tyr Ser Val Phe Phe Phe Ile Val Val Ile 
    370                 375                 380                 


Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Thr Leu Ala Val Val Thr 
385                 390                 395                 400 


Met Ala Tyr Glu Glu Gln Asn Lys Asn Val Ala Ala Glu Ile Glu Ala 
                405                 410                 415     


Lys Glu Lys Met Phe Gln Glu Ala Gln Gln Leu Leu Lys Glu Glu Lys 
            420                 425                 430         


Glu Ala Leu Val Ala Met Gly Ile Asp Arg Ser Ser Leu Thr Ser Leu 
        435                 440                 445             


Glu Thr Ser Tyr Phe Thr Pro Lys Lys Arg Lys Leu Phe Gly Asn Lys 
    450                 455                 460                 


Lys Arg Lys Ser Phe Phe Leu Arg Glu Ser Gly Lys Asp Gln Pro Pro 
465                 470                 475                 480 


Gly Ser Asp Ser Asp Glu Asp Cys Gln Lys Lys Pro Gln Leu Leu Glu 
                485                 490                 495     


Gln Thr Lys Arg Leu Ser Gln Asn Leu Ser Leu Asp His Phe Asp Glu 
            500                 505                 510         


His Gly Asp Pro Leu Gln Arg Gln Arg Ala Leu Ser Ala Val Ser Ile 
        515                 520                 525             


Leu Thr Ile Thr Met Lys Glu Gln Glu Lys Ser Gln Glu Pro Cys Leu 
    530                 535                 540                 


Pro Cys Gly Glu Asn Leu Ala Ser Lys Tyr Leu Val Trp Asn Cys Cys 
545                 550                 555                 560 


Pro Gln Trp Leu Cys Val Lys Lys Val Leu Arg Thr Val Met Thr Asp 
                565                 570                 575     


Pro Phe Thr Glu Leu Ala Ile Thr Ile Cys Ile Ile Ile Asn Thr Val 
            580                 585                 590         


Phe Leu Ala Met Glu His His Lys Met Glu Ala Ser Phe Glu Lys Met 
        595                 600                 605             


Leu Asn Ile Gly Asn Leu Val Phe Thr Ser Ile Phe Ile Ala Glu Met 
    610                 615                 620                 


Cys Leu Lys Ile Ile Ala Leu Asp Pro Tyr His Tyr Phe Arg Arg Gly 
625                 630                 635                 640 


Trp Asn Ile Phe Asp Ser Ile Val Ala Leu Leu Ser Phe Ala Asp Val 
                645                 650                 655     


Met Asn Cys Val Leu Gln Lys Arg Ser Trp Pro Phe Leu Arg Ser Phe 
            660                 665                 670         


Arg Val Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn 
        675                 680                 685             


Thr Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Ser Leu 
    690                 695                 700                 


Thr Val Val Leu Val Ile Val Ile Phe Ile Phe Ser Val Val Gly Met 
705                 710                 715                 720 


Gln Leu Phe Gly Arg Ser Phe Asn Ser Gln Lys Ser Pro Lys Leu Cys 
                725                 730                 735     


Asn Pro Thr Gly Pro Thr Val Ser Cys Leu Arg His Trp His Met Gly 
            740                 745                 750         


Asp Phe Trp His Ser Phe Leu Val Val Phe Arg Ile Leu Cys Gly Glu 
        755                 760                 765             


Trp Ile Glu Asn Met Trp Glu Cys Met Gln Glu Ala Asn Ala Ser Ser 
    770                 775                 780                 


Ser Leu Cys Val Ile Val Phe Ile Leu Ile Thr Val Ile Gly Lys Leu 
785                 790                 795                 800 


Val Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Asn 
                805                 810                 815     


Glu Glu Arg Asn Gly Asn Leu Glu Gly Glu Ala Arg Lys Thr Lys Val 
            820                 825                 830         


Gln Leu Ala Leu Asp Arg Phe Arg Arg Ala Phe Cys Phe Val Arg His 
        835                 840                 845             


Thr Leu Glu His Phe Cys His Lys Trp Cys Arg Lys Gln Asn Leu Pro 
    850                 855                 860                 


Gln Gln Lys Glu Val Ala Gly Gly Cys Ala Ala Gln Ser Lys Asp Ile 
865                 870                 875                 880 


Ile Pro Leu Val Met Glu Met Lys Arg Gly Ser Glu Thr Gln Glu Glu 
                885                 890                 895     


Leu Gly Ile Leu Thr Ser Val Pro Lys Thr Leu Gly Val Arg His Asp 
            900                 905                 910         


Trp Thr Trp Leu Ala Pro Leu Ala Glu Glu Glu Asp Asp Val Glu Phe 
        915                 920                 925             


Ser Gly Glu Asp Asn Ala Gln Arg Ile Thr Gln Pro Glu Pro Glu Gln 
    930                 935                 940                 


Gln Ala Tyr Glu Leu His Gln Glu Asn Lys Lys Pro Thr Ser Gln Arg 
945                 950                 955                 960 


Val Gln Ser Val Glu Ile Asp Met Phe Ser Glu Asp Glu Pro His Leu 
                965                 970                 975     


Thr Ile Gln Asp Pro Arg Lys Lys Ser Asp Val Thr Ser Ile Leu Ser 
            980                 985                 990         


Glu Cys Ser Thr Ile Asp Leu Gln  Asp Gly Phe Gly Trp  Leu Pro Glu 
        995                 1000                 1005             


Met Val  Pro Lys Lys Gln Pro  Glu Arg Cys Leu Pro  Lys Gly Phe 
    1010                 1015                 1020             


Gly Cys  Cys Phe Pro Cys Cys  Ser Val Asp Lys Arg  Lys Pro Pro 
    1025                 1030                 1035             


Trp Val  Ile Trp Trp Asn Leu  Arg Lys Thr Cys Tyr  Gln Ile Val 
    1040                 1045                 1050             


Lys His  Ser Trp Phe Glu Ser  Phe Ile Ile Phe Val  Ile Leu Leu 
    1055                 1060                 1065             


Ser Ser  Gly Ala Leu Ile Phe  Glu Asp Val His Leu  Glu Asn Gln 
    1070                 1075                 1080             


Pro Lys  Ile Gln Glu Leu Leu  Asn Cys Thr Asp Ile  Ile Phe Thr 
    1085                 1090                 1095             


His Ile  Phe Ile Leu Glu Met  Val Leu Lys Trp Val  Ala Phe Gly 
    1100                 1105                 1110             


Phe Gly  Lys Tyr Phe Thr Ser  Ala Trp Cys Cys Leu  Asp Phe Ile 
    1115                 1120                 1125             


Ile Val  Ile Val Ser Val Thr  Thr Leu Ile Asn Leu  Met Glu Leu 
    1130                 1135                 1140             


Lys Ser  Phe Arg Thr Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu 
    1145                 1150                 1155             


Ser Gln  Phe Glu Gly Met Lys  Val Val Val Asn Ala  Leu Ile Gly 
    1160                 1165                 1170             


Ala Ile  Pro Ala Ile Leu Asn  Val Leu Leu Val Cys  Leu Ile Phe 
    1175                 1180                 1185             


Trp Leu  Val Phe Cys Ile Leu  Gly Val Tyr Phe Phe  Ser Gly Lys 
    1190                 1195                 1200             


Phe Gly  Lys Cys Ile Asn Gly  Thr Asp Ser Val Ile  Asn Tyr Thr 
    1205                 1210                 1215             


Ile Ile  Thr Asn Lys Ser Gln  Cys Glu Ser Gly Asn  Phe Ser Trp 
    1220                 1225                 1230             


Ile Asn  Gln Lys Val Asn Phe  Asp Asn Val Gly Asn  Ala Tyr Leu 
    1235                 1240                 1245             


Ala Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Ile 
    1250                 1255                 1260             


Tyr Ala  Ala Val Asp Ser Thr  Glu Lys Glu Gln Gln  Pro Glu Phe 
    1265                 1270                 1275             


Glu Ser  Asn Ser Leu Gly Tyr  Ile Tyr Phe Val Val  Phe Ile Ile 
    1280                 1285                 1290             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1295                 1300                 1305             


Asp Asn  Phe Asn Gln Gln Gln  Lys Lys Leu Gly Gly  Gln Asp Ile 
    1310                 1315                 1320             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1325                 1330                 1335             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Leu Asn 
    1340                 1345                 1350             


Lys Cys  Gln Gly Leu Val Phe  Asp Ile Val Thr Ser  Gln Ile Phe 
    1355                 1360                 1365             


Asp Ile  Ile Ile Ile Ser Leu  Ile Ile Leu Asn Met  Ile Ser Met 
    1370                 1375                 1380             


Met Ala  Glu Ser Tyr Asn Gln  Pro Lys Ala Met Lys  Ser Ile Leu 
    1385                 1390                 1395             


Asp His  Leu Asn Trp Val Phe  Val Val Ile Phe Thr  Leu Glu Cys 
    1400                 1405                 1410             


Leu Ile  Lys Ile Phe Ala Leu  Arg Gln Tyr Tyr Phe  Thr Asn Gly 
    1415                 1420                 1425             


Trp Asn  Leu Phe Asp Cys Val  Val Val Leu Leu Ser  Ile Val Ser 
    1430                 1435                 1440             


Thr Met  Ile Ser Thr Leu Glu  Asn Gln Glu His Ile  Pro Phe Pro 
    1445                 1450                 1455             


Pro Thr  Leu Phe Arg Ile Val  Arg Leu Ala Arg Ile  Gly Arg Ile 
    1460                 1465                 1470             


Leu Arg  Leu Val Arg Ala Ala  Arg Gly Ile Arg Thr  Leu Leu Phe 
    1475                 1480                 1485             


Ala Leu  Met Met Ser Leu Pro  Ser Leu Phe Asn Ile  Gly Leu Leu 
    1490                 1495                 1500             


Leu Phe  Leu Ile Met Phe Ile  Tyr Ala Ile Leu Gly  Met Asn Trp 
    1505                 1510                 1515             


Phe Ser  Lys Val Asn Pro Glu  Ser Gly Ile Asp Asp  Ile Phe Asn 
    1520                 1525                 1530             


Phe Lys  Thr Phe Ala Ser Ser  Met Leu Cys Leu Phe  Gln Ile Ser 
    1535                 1540                 1545             


Thr Ser  Ala Gly Trp Asp Ser  Leu Leu Ser Pro Met  Leu Arg Ser 
    1550                 1555                 1560             


Lys Glu  Ser Cys Asn Ser Ser  Ser Glu Asn Cys His  Leu Pro Gly 
    1565                 1570                 1575             


Ile Ala  Thr Ser Tyr Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu 
    1580                 1585                 1590             


Ile Val  Val Asn Met Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Asn 
    1595                 1600                 1605             


Thr Ala  Thr Glu Glu Ser Glu  Asp Pro Leu Gly Glu  Asp Asp Phe 
    1610                 1615                 1620             


Asp Ile  Phe Tyr Glu Val Trp  Glu Lys Phe Asp Pro  Glu Ala Thr 
    1625                 1630                 1635             


Gln Phe  Ile Lys Tyr Ser Ala  Leu Ser Asp Phe Ala  Asp Ala Leu 
    1640                 1645                 1650             


Pro Glu  Pro Leu Arg Val Ala  Lys Pro Asn Lys Tyr  Gln Phe Leu 
    1655                 1660                 1665             


Val Met  Asp Leu Pro Met Val  Ser Glu Asp Arg Leu  His Cys Met 
    1670                 1675                 1680             


Asp Ile  Leu Phe Ala Phe Thr  Ala Arg Val Leu Gly  Gly Ser Asp 
    1685                 1690                 1695             


Gly Leu  Asp Ser Met Lys Ala  Met Met Glu Glu Lys  Phe Met Glu 
    1700                 1705                 1710             


Ala Asn  Pro Leu Lys Lys Leu  Tyr Glu Pro Ile Val  Thr Thr Thr 
    1715                 1720                 1725             


Lys Arg  Lys Glu Glu Glu Arg  Gly Ala Ala Ile Ile  Gln Lys Ala 
    1730                 1735                 1740             


Phe Arg  Lys Tyr Met Met Lys  Val Thr Lys Gly Asp  Gln Gly Asp 
    1745                 1750                 1755             


Gln Asn  Asp Leu Glu Asn Gly  Pro His Ser Pro Leu  Gln Thr Leu 
    1760                 1765                 1770             


Cys Asn  Gly Asp Leu Ser Ser  Phe Gly Val Ala Lys  Gly Lys Val 
    1775                 1780                 1785             


His Cys  Asp 
    1790     


<210>  31
<211>  1988
<212>  PRT
<213>  Macaca mulatta

<400>  31

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Ile Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Val Gln Asn Ser Leu Val Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Met Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Asp Ser Glu Glu Asn Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Ser Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Ile Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp 
                645                 650                 655     


Asp Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys 
                725                 730                 735     


Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
            740                 745                 750         


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met 
        755                 760                 765             


Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr 
    770                 775                 780                 


Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro 
785                 790                 795                 800 


Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 
                805                 810                 815     


Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 
            820                 825                 830         


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
        835                 840                 845             


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
    850                 855                 860                 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
865                 870                 875                 880 


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
                885                 890                 895     


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
            900                 905                 910         


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
        915                 920                 925             


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 
    930                 935                 940                 


Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
945                 950                 955                 960 


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
                965                 970                 975     


Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn Leu Gln Ile Ala Val 
            980                 985                 990         


Thr Arg Ile Lys Lys Gly Ile Asn  Tyr Val Lys Gln Thr  Leu Arg Glu 
        995                 1000                 1005             


Phe Ile  Leu Lys Thr Phe Ser  Lys Lys Pro Lys Ile  Ser Arg Glu 
    1010                 1015                 1020             


Ile Arg  Gln Thr Glu Asp Leu  Asn Thr Lys Lys Glu  Asn Tyr Ile 
    1025                 1030                 1035             


Ser Asn  Tyr Thr Leu Ala Glu  Met Ser Lys Gly His  Asn Phe Leu 
    1040                 1045                 1050             


Lys Glu  Lys Asp Lys Ile Ser  Gly Phe Gly Ser Cys  Val Asp Lys 
    1055                 1060                 1065             


Tyr Leu  Met Glu Asp Ser Asp  Gly Gln Ser Phe Ile  His Asn Pro 
    1070                 1075                 1080             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu 
    1085                 1090                 1095             


Glu Asn  Met Asn Thr Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu 
    1100                 1105                 1110             


Tyr Ser  Lys Val Arg Leu Asn  Gln Ser Ser Ser Ser  Glu Cys Ser 
    1115                 1120                 1125             


Thr Val  Asp Asn Pro Leu Pro  Gly Glu Gly Glu Glu  Ala Glu Ala 
    1130                 1135                 1140             


Glu Pro  Met Asn Ser Asp Glu  Pro Glu Ala Cys Phe  Thr Asp Gly 
    1145                 1150                 1155             


Cys Val  Arg Arg Phe Ser Cys  Cys Gln Val Asn Ile  Glu Ser Gly 
    1160                 1165                 1170             


Lys Gly  Lys Ile Trp Trp Asn  Ile Arg Lys Thr Cys  Tyr Lys Ile 
    1175                 1180                 1185             


Val Glu  His Ser Trp Phe Glu  Ser Phe Ile Val Leu  Met Ile Leu 
    1190                 1195                 1200             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Arg 
    1205                 1210                 1215             


Lys Lys  Thr Ile Lys Ile Ile  Leu Glu Tyr Ala Asp  Lys Ile Phe 
    1220                 1225                 1230             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Ile Ala Tyr 
    1235                 1240                 1245             


Gly Tyr  Lys Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1250                 1255                 1260             


Leu Ile  Val Asp Val Ser Leu  Val Thr Leu Val Ala  Asn Thr Leu 
    1265                 1270                 1275             


Gly Tyr  Ser Asp Leu Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1280                 1285                 1290             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1295                 1300                 1305             


Val Val  Val Asn Ala Leu Ile  Gly Ala Ile Pro Ser  Ile Met Asn 
    1310                 1315                 1320             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1325                 1330                 1335             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr Glu Cys  Ile Asn Thr 
    1340                 1345                 1350             


Thr Asp  Gly Ser Arg Phe Pro  Ala Ser Gln Val Pro  Asn Arg Ser 
    1355                 1360                 1365             


Glu Cys  Phe Ala Leu Met Asn  Val Ser Gln Asn Val  Arg Trp Lys 
    1370                 1375                 1380             


Asn Leu  Lys Val Asn Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser 
    1385                 1390                 1395             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Thr Ile  Ile Met Tyr 
    1400                 1405                 1410             


Ala Ala  Val Asp Ser Val Asn  Val Asp Lys Gln Pro  Lys Tyr Glu 
    1415                 1420                 1425             


Tyr Ser  Leu Tyr Met Tyr Ile  Tyr Phe Val Ile Phe  Ile Ile Phe 
    1430                 1435                 1440             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1445                 1450                 1455             


Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe 
    1460                 1465                 1470             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1475                 1480                 1485             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1490                 1495                 1500             


Ile Gln  Gly Cys Ile Phe Asp  Leu Val Thr Asn Gln  Ala Phe Asp 
    1505                 1510                 1515             


Ile Ser  Ile Met Val Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1520                 1525                 1530             


Val Glu  Lys Glu Gly Gln Ser  Pro Tyr Met Thr Asp  Val Leu Tyr 
    1535                 1540                 1545             


Trp Ile  Asn Val Val Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val 
    1550                 1555                 1560             


Leu Lys  Leu Ile Ser Leu Arg  Tyr Tyr Tyr Phe Thr  Ile Gly Trp 
    1565                 1570                 1575             


Asn Ile  Phe Asp Phe Val Val  Val Ile Ile Ser Ile  Val Gly Met 
    1580                 1585                 1590             


Phe Leu  Ala Asp Leu Ile Glu  Thr Tyr Phe Val Ser  Pro Thr Leu 
    1595                 1600                 1605             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1610                 1615                 1620             


Val Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1625                 1630                 1635             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1640                 1645                 1650             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1655                 1660                 1665             


Val Lys  Lys Glu Asp Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr 
    1670                 1675                 1680             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1685                 1690                 1695             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro 
    1700                 1705                 1710             


Asp Cys  Asp Pro Lys Lys Val  His Pro Gly Ser Ser  Val Glu Gly 
    1715                 1720                 1725             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr 
    1730                 1735                 1740             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1745                 1750                 1755             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1760                 1765                 1770             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1775                 1780                 1785             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Tyr Asn  Lys Leu Ser 
    1790                 1795                 1800             


Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1805                 1810                 1815             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1820                 1825                 1830             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1835                 1840                 1845             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met 
    1850                 1855                 1860             


Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1865                 1870                 1875             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala 
    1880                 1885                 1890             


Thr Val  Ile Gln Arg Ala Tyr  Arg Arg Tyr Arg Leu  Arg Gln Asn 
    1895                 1900                 1905             


Val Lys  Asn Ile Ser Ser Ile  Tyr Ile Lys Asp Gly  Asp Arg Asp 
    1910                 1915                 1920             


Asp Asp  Leu Leu Asn Lys Lys  Asp Met Ala Phe Asp  Asn Val Asn 
    1925                 1930                 1935             


Glu Asn  Ser Ser Pro Glu Lys  Thr Asp Ala Thr Ser  Ser Thr Thr 
    1940                 1945                 1950             


Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Lys Pro Asp  Lys Glu Lys 
    1955                 1960                 1965             


Tyr Glu  Gln Asp Arg Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Ser 
    1970                 1975                 1980             


Lys Glu  Ser Lys Lys 
    1985             


<210>  32
<211>  1988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Galeopterus variegatus

<400>  32

Met Ala Met Leu Pro Pro Pro Arg Pro Gln Ser Phe Val Arg Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Gly Lys Thr 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Ser Asp Glu Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Asp Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Phe Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Phe Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Leu Ser Thr Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Gln Ser 
        275                 280                 285             


Ile Ile Glu Thr Leu Glu Thr Glu Glu Asp Tyr Arg Arg Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ala Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Arg Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Glu Gln Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Val Ala Val Ala Glu His Thr 
        435                 440                 445             


Ser Ile Gly Arg Ser Arg Ile Met Gly Val Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Asp Glu Lys Leu Ser Lys Ser Glu Ser Glu Glu Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe Tyr Leu Gly Val Glu Gly His Gly Arg Ala Arg Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Lys Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp 
                645                 650                 655     


Asp Ser Gly Thr Thr Asn Gln Ile Arg Lys Lys Arg Arg Ser Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Lys Phe Ala His Thr 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Phe Trp Ile Lys Phe Lys Lys Leu 
                725                 730                 735     


Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
            740                 745                 750         


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met 
        755                 760                 765             


Thr Asn Glu Phe Lys Asn Ala Leu Ala Val Gly Asn Leu Val Phe Thr 
    770                 775                 780                 


Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro 
785                 790                 795                 800 


Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 
                805                 810                 815     


Thr Leu Ser Leu Val Glu Leu Cys Leu Ser Glu Val Glu Gly Leu Ser 
            820                 825                 830         


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
        835                 840                 845             


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
    850                 855                 860                 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
865                 870                 875                 880 


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
                885                 890                 895     


Cys Lys Ile Ser Asp Asp Cys Thr Leu Pro Arg Trp His Met Thr Asp 
            900                 905                 910         


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
        915                 920                 925             


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 
    930                 935                 940                 


Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
945                 950                 955                 960 


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
                965                 970                 975     


Thr Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val 
            980                 985                 990         


Ala Arg Ile Asn Lys Gly Val Asn  Tyr Met Lys Gln Ser  Leu Arg Glu 
        995                 1000                 1005             


Cys Ile  Leu Lys Ala Phe Ser  Lys Lys Pro Lys Ile  Ser Gly Glu 
    1010                 1015                 1020             


Ile Lys  Arg Ala Glu Asn Ile  Asn Ser Lys Lys Glu  Asn Tyr Val 
    1025                 1030                 1035             


Ser Asn  Arg Thr Leu Ala Glu  Met Ser Lys Asp His  Ser Phe Tyr 
    1040                 1045                 1050             


Lys Glu  Lys Asp Lys Ile Gly  Gly Leu Gly Ser Ser  Met Asp Lys 
    1055                 1060                 1065             


Tyr Leu  Met Asp Glu Ser Asp  Tyr Gln Ser Phe Ile  His Asn Pro 
    1070                 1075                 1080             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu 
    1085                 1090                 1095             


Glu Asn  Met Asn Thr Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu 
    1100                 1105                 1110             


Cys Thr  Lys Glu Val Leu Asn  Arg Ser Ser Ser Ser  Glu Cys Ser 
    1115                 1120                 1125             


Thr Val  Asp Asn Pro Val Pro  Gly Glu Gly Glu Glu  Ala Glu Ala 
    1130                 1135                 1140             


Glu Pro  Val Asn Ser Asp Glu  Pro Glu Ala Cys Phe  Thr Asp Gly 
    1145                 1150                 1155             


Cys Val  Arg Arg Phe Pro Cys  Cys Gln Val Asn Ile  Glu Ser Gly 
    1160                 1165                 1170             


Lys Gly  Lys Ile Trp Trp Asn  Ile Arg Lys Thr Cys  Tyr Lys Ile 
    1175                 1180                 1185             


Val Glu  His Ser Trp Phe Glu  Ser Phe Ile Val Leu  Met Ile Leu 
    1190                 1195                 1200             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Arg 
    1205                 1210                 1215             


Lys Lys  Thr Ile Lys Ile Ile  Leu Glu Tyr Ala Asp  Lys Ile Phe 
    1220                 1225                 1230             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Val Ala Tyr 
    1235                 1240                 1245             


Gly Tyr  Lys Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1250                 1255                 1260             


Leu Ile  Val Asp Val Ser Leu  Val Thr Leu Val Ala  Asn Thr Leu 
    1265                 1270                 1275             


Gly Tyr  Ser Asp Leu Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1280                 1285                 1290             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1295                 1300                 1305             


Val Val  Val Asn Ala Leu Ile  Gly Ala Ile Pro Ser  Ile Met Asn 
    1310                 1315                 1320             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1325                 1330                 1335             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr Glu Cys  Ile Asn Thr 
    1340                 1345                 1350             


Thr Asp  Gly Ser Arg Phe Pro  Thr Thr Gln Val Ser  Asn Arg Ser 
    1355                 1360                 1365             


Asp Cys  Phe Ala Leu Met Asn  Val Ser Gln Asn Val  Arg Trp Lys 
    1370                 1375                 1380             


Asn Leu  Lys Val Asn Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser 
    1385                 1390                 1395             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Met Asp  Ile Met Tyr 
    1400                 1405                 1410             


Ala Ala  Val Asp Ser Val Asn  Val Asp Lys Gln Pro  Lys Tyr Glu 
    1415                 1420                 1425             


Tyr Ser  Ile Tyr Met Tyr Ile  Tyr Phe Val Ile Phe  Ile Ile Phe 
    1430                 1435                 1440             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1445                 1450                 1455             


Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe 
    1460                 1465                 1470             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1475                 1480                 1485             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1490                 1495                 1500             


Phe Gln  Gly Cys Ile Phe Asp  Leu Val Thr Asn Gln  Val Phe Asp 
    1505                 1510                 1515             


Ile Thr  Ile Met Val Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1520                 1525                 1530             


Val Glu  Lys Glu Glu Gln Ser  Gln Tyr Met Val Asp  Val Leu Tyr 
    1535                 1540                 1545             


Trp Ile  Asn Val Ala Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val 
    1550                 1555                 1560             


Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr Phe Thr  Val Gly Trp 
    1565                 1570                 1575             


Asn Ile  Phe Asp Phe Val Val  Val Ile Leu Ser Ile  Val Gly Met 
    1580                 1585                 1590             


Phe Leu  Ala Asp Leu Ile Glu  Lys Tyr Phe Val Ser  Pro Thr Leu 
    1595                 1600                 1605             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1610                 1615                 1620             


Ile Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1625                 1630                 1635             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1640                 1645                 1650             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1655                 1660                 1665             


Val Lys  Lys Glu Ala Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr 
    1670                 1675                 1680             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1685                 1690                 1695             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Ala Pro Pro 
    1700                 1705                 1710             


Asp Cys  Asp Pro Lys Lys Val  His Pro Gly Ser Ser  Val Glu Gly 
    1715                 1720                 1725             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr 
    1730                 1735                 1740             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1745                 1750                 1755             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1760                 1765                 1770             


Leu Gly  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1775                 1780                 1785             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Tyr Ser  Lys Leu Ser 
    1790                 1795                 1800             


Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1805                 1810                 1815             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1820                 1825                 1830             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1835                 1840                 1845             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met 
    1850                 1855                 1860             


Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1865                 1870                 1875             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala 
    1880                 1885                 1890             


Thr Val  Ile Gln Arg Ala Phe  Arg Arg Tyr Arg Leu  Arg Gln Asn 
    1895                 1900                 1905             


Val Lys  Asn Ile Ser Ser Met  Tyr Ile Lys Asp Gly  Asp Arg Asp 
    1910                 1915                 1920             


Asp Asp  Leu Pro His Lys Glu  Asp Val Val Phe Gly  Asn Val Asn 
    1925                 1930                 1935             


Gly Asn  Ser Ser Pro Glu Lys  Thr Asp Ala Thr Pro  Ser Thr Val 
    1940                 1945                 1950             


Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Met Pro Asp  Lys Glu Lys 
    1955                 1960                 1965             


Tyr Glu  Lys Asp Lys Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Gly 
    1970                 1975                 1980             


Lys Glu  Ser Lys Lys 
    1985             


<210>  33
<211>  1987
<212>  PRT
<213>  Bos taurus

<400>  33

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val Phe Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Gly Lys Ala 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Asp Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ala Ala Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Ile Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Val Gln Ser Ser Leu Ala Asn Asn Glu Thr Met Glu Asn 
        275                 280                 285             


Ile Leu Asn Thr Leu Asp Glu Glu Glu Tyr Ala Lys Tyr Phe Tyr Tyr 
    290                 295                 300                 


Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Ser Asp Ser 
305                 310                 315                 320 


Gly Gln Cys Pro Glu Gly Tyr Thr Cys Lys Lys Ile Gly Arg Asn Pro 
                325                 330                 335     


Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala 
            340                 345                 350         


Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Gln 
        355                 360                 365             


Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Val 
    370                 375                 380                 


Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val 
385                 390                 395                 400 


Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala Arg 
                405                 410                 415     


Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys Glu 
            420                 425                 430         


Gln Glu Glu Ala Glu Ala Ile Ala Leu Ala Ala Ala Glu Tyr Thr Ser 
        435                 440                 445             


Ile Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu Thr 
    450                 455                 460                 


Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Arg 
465                 470                 475                 480 


Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asp 
                485                 490                 495     


Glu Lys Leu Ser Lys Ser Glu Ser Glu Glu Ser Ile Arg Arg Lys Ser 
            500                 505                 510         


Phe His Leu Gly Val Glu Gly His Arg Arg Ala Arg Glu Lys Arg Leu 
        515                 520                 525             


Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
    530                 535                 540                 


Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
545                 550                 555                 560 


Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                565                 570                 575     


Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
            580                 585                 590         


Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
        595                 600                 605             


Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
    610                 615                 620                 


Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
625                 630                 635                 640 


Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                645                 650                 655     


Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg His Ser Ser Tyr 
            660                 665                 670         


Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg Ala 
        675                 680                 685             


Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
    690                 695                 700                 


Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
705                 710                 715                 720 


Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Phe Ile 
                725                 730                 735     


Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
            740                 745                 750         


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
        755                 760                 765             


Glu Glu Phe Lys Asn Val Leu Val Val Gly Asn Leu Val Phe Thr Gly 
    770                 775                 780                 


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
785                 790                 795                 800 


Glu Tyr Phe Gln Ile Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                805                 810                 815     


Leu Ser Leu Val Glu Leu Phe Leu Ser Asp Val Glu Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
        835                 840                 845             


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
    850                 855                 860                 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
865                 870                 875                 880 


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
                885                 890                 895     


Lys Ile Asn Glu Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe 
            900                 905                 910         


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
        915                 920                 925             


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu 
    930                 935                 940                 


Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
945                 950                 955                 960 


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr 
                965                 970                 975     


Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Ala 
            980                 985                 990         


Arg Ile Lys Lys Gly Ile Asn Tyr  Val Lys Gln Thr Leu  Arg Glu Phe 
        995                 1000                 1005             


Val Leu  Lys Ala Phe Ser Lys  Lys Pro Lys Ile Ser  Lys Glu Ile 
    1010                 1015                 1020             


Arg Gln  Thr Glu Asp Leu Asn  Cys Lys Lys Glu Asn  Tyr Ile Ser 
    1025                 1030                 1035             


Asn Arg  Thr Leu Ala Glu Met  Ser Lys Asp His Lys  Phe His Lys 
    1040                 1045                 1050             


Glu Lys  Asp Lys Thr Ser Gly  Phe Gly Asn Ser Met  Asp Lys Tyr 
    1055                 1060                 1065             


Leu Met  Glu Glu Ser Asp Gly  Gln Ser Phe Ile His  Asn Pro Ser 
    1070                 1075                 1080             


Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly Glu Ser  Asp Leu Glu 
    1085                 1090                 1095             


Ile Met  Asn Thr Glu Glu Leu  Ser Ser Asp Ser Asp  Ser Glu Tyr 
    1100                 1105                 1110             


Ser Lys  Gly Arg Leu Asn Gln  Ser Ser Ser Ser Glu  Cys Ser Thr 
    1115                 1120                 1125             


Val Asp  Asn Pro Val Pro Gly  Glu Gly Glu Glu Ala  Glu Ala Glu 
    1130                 1135                 1140             


Pro Val  Asn Ser Asp Glu Pro  Glu Ala Cys Phe Thr  Asp Gly Cys 
    1145                 1150                 1155             


Val Gln  Arg Phe Pro Cys Cys  Gln Val Asn Ile Glu  Ser Gly Lys 
    1160                 1165                 1170             


Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr Cys Phe  Arg Ile Val 
    1175                 1180                 1185             


Glu His  Ser Trp Phe Glu Ser  Phe Ile Val Leu Met  Ile Leu Leu 
    1190                 1195                 1200             


Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile Tyr Ile  Glu Lys Lys 
    1205                 1210                 1215             


Lys Asn  Ile Lys Ile Ile Leu  Glu Tyr Ala Asp Lys  Ile Phe Thr 
    1220                 1225                 1230             


Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys Trp Val  Ala Tyr Gly 
    1235                 1240                 1245             


Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys Trp Leu  Asp Phe Leu 
    1250                 1255                 1260             


Ile Val  Asp Val Ser Leu Val  Thr Leu Val Ala Asn  Thr Leu Gly 
    1265                 1270                 1275             


Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu Arg Thr  Leu Arg Ala 
    1280                 1285                 1290             


Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe Glu Gly  Met Arg Val 
    1295                 1300                 1305             


Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro Ser Ile  Met Asn Val 
    1310                 1315                 1320             


Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile Phe Ser  Ile Met Gly 
    1325                 1330                 1335             


Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu Cys Ile  Asn Thr Thr 
    1340                 1345                 1350             


Asn Gly  Leu Arg Phe Pro Thr  Ser Glu Val Glu Asn  Arg Ser Ala 
    1355                 1360                 1365             


Cys Leu  Ala Leu Met Asn Val  Ser Gln Asn Val Arg  Trp Lys Asn 
    1370                 1375                 1380             


Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu Gly Tyr  Leu Ser Leu 
    1385                 1390                 1395             


Leu Gln  Val Ala Thr Phe Lys  Gly Trp Met Asp Ile  Met Tyr Ala 
    1400                 1405                 1410             


Ala Val  Asp Ser Val Asn Val  Asn Lys Gln Pro Ile  Tyr Glu Tyr 
    1415                 1420                 1425             


Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Ile Phe Ile  Ile Phe Gly 
    1430                 1435                 1440             


Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly Val Ile  Ile Asp Asn 
    1445                 1450                 1455             


Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly Gln Asp  Ile Phe Met 
    1460                 1465                 1470             


Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala Met Lys  Lys Leu Gly 
    1475                 1480                 1485             


Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg Pro Gly  Asn Lys Phe 
    1490                 1495                 1500             


Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn Gln Ala  Phe Asp Ile 
    1505                 1510                 1515             


Ala Ile  Met Val Leu Ile Cys  Leu Asn Met Val Thr  Met Met Val 
    1520                 1525                 1530             


Glu Lys  Glu Gly Gln Ser Asp  Tyr Val Thr Glu Val  Leu Asn Trp 
    1535                 1540                 1545             


Ile Asn  Val Val Phe Ile Ile  Leu Phe Ser Gly Glu  Cys Val Leu 
    1550                 1555                 1560             


Lys Leu  Ile Ser Leu Arg Cys  Tyr Tyr Phe Thr Val  Gly Trp Asn 
    1565                 1570                 1575             


Ile Phe  Asp Phe Val Val Val  Ile Leu Ser Ile Val  Gly Met Phe 
    1580                 1585                 1590             


Leu Ala  Asp Leu Ile Glu Arg  Tyr Phe Val Ser Pro  Thr Leu Phe 
    1595                 1600                 1605             


Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg Ile Leu  Arg Leu Ile 
    1610                 1615                 1620             


Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu Phe Ala  Leu Met Met 
    1625                 1630                 1635             


Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu Leu Leu  Phe Leu Val 
    1640                 1645                 1650             


Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser Asn Phe  Ala Tyr Val 
    1655                 1660                 1665             


Lys Lys  Glu Ala Gly Ile Asn  Asp Met Phe Asn Phe  Glu Thr Phe 
    1670                 1675                 1680             


Ala Asn  Ser Met Ile Cys Leu  Phe Gln Ile Thr Thr  Ser Ala Gly 
    1685                 1690                 1695             


Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn Ser Lys  Pro Pro Asp 
    1700                 1705                 1710             


Cys Asp  Pro Lys Lys Val His  Pro Gly Ser Ser Val  Glu Gly Asp 
    1715                 1720                 1725             


Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr Phe Val  Ser Tyr Ile 
    1730                 1735                 1740             


Ile Ile  Ser Phe Leu Val Val  Val Asn Met Tyr Ile  Ala Val Ile 
    1745                 1750                 1755             


Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu Ser Thr  Glu Pro Leu 
    1760                 1765                 1770             


Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu Val Trp  Glu Lys Phe 
    1775                 1780                 1785             


Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Tyr Ser Lys  Leu Ser Asp 
    1790                 1795                 1800             


Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu Ile Ala  Lys Pro Asn 
    1805                 1810                 1815             


Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro Met Val  Ser Gly Asp 
    1820                 1825                 1830             


Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala Phe Thr  Lys Arg Val 
    1835                 1840                 1845             


Leu Gly  Glu Gly Gly Glu Met  Asp Ser Leu Arg Ser  Gln Met Glu 
    1850                 1855                 1860             


Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys Val Ser  Tyr Glu Pro 
    1865                 1870                 1875             


Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu Asp Val  Ser Ala Thr 
    1880                 1885                 1890             


Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg Leu Arg  Gln Asn Val 
    1895                 1900                 1905             


Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp Gly Asp  Arg Asp Asp 
    1910                 1915                 1920             


Asp Leu  Pro Asn Lys Glu Asp  Met Val Phe Asp Asn  Val Asn Glu 
    1925                 1930                 1935             


Asn Ser  Ser Pro Glu Lys Thr  Gly Ala Thr Pro Ser  Thr Val Ser 
    1940                 1945                 1950             


Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro Asp Arg  Glu Lys Tyr 
    1955                 1960                 1965             


Glu Lys  Asp Lys Thr Glu Lys  Glu Asp Lys Gly Lys  Asp Gly Lys 
    1970                 1975                 1980             


Glu Gly  Lys Lys 
    1985         


<210>  34
<211>  1987
<212>  PRT
<213>  Ovis aries

<400>  34

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val Phe Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Gly Lys Ala 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ala Ala Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Ile Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Val Gln Thr Ser Leu Ala Asn Asn Glu Thr Ile Glu Asp 
        275                 280                 285             


Ile Leu Asn Ala Leu Asp Glu Glu Glu Tyr Ala Lys Tyr Phe Tyr Tyr 
    290                 295                 300                 


Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser 
305                 310                 315                 320 


Gly Gln Cys Pro Glu Gly Tyr Thr Cys Lys Lys Ile Gly Arg Asn Pro 
                325                 330                 335     


Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala 
            340                 345                 350         


Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Gln 
        355                 360                 365             


Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Val 
    370                 375                 380                 


Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val 
385                 390                 395                 400 


Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala Arg 
                405                 410                 415     


Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys Glu 
            420                 425                 430         


Gln Glu Glu Ala Glu Ala Ile Ala Leu Ala Ala Ala Glu Tyr Thr Ser 
        435                 440                 445             


Ile Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu Thr 
    450                 455                 460                 


Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Arg 
465                 470                 475                 480 


Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asp 
                485                 490                 495     


Glu Lys Leu Ser Lys Ser Glu Ser Glu Glu Ser Ile Arg Arg Lys Ser 
            500                 505                 510         


Phe His Leu Gly Val Glu Gly His Arg Arg Ala Arg Glu Lys Arg Leu 
        515                 520                 525             


Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
    530                 535                 540                 


Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
545                 550                 555                 560 


Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                565                 570                 575     


Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
            580                 585                 590         


Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
        595                 600                 605             


Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
    610                 615                 620                 


Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
625                 630                 635                 640 


Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                645                 650                 655     


Ser Gly Thr Thr Asn Gln Ile Tyr Lys Lys Arg Arg His Ser Ser Tyr 
            660                 665                 670         


Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg Ala 
        675                 680                 685             


Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
    690                 695                 700                 


Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
705                 710                 715                 720 


Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Phe Ile 
                725                 730                 735     


Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
            740                 745                 750         


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
        755                 760                 765             


Glu Glu Phe Lys Asn Val Leu Val Val Gly Asn Leu Val Phe Thr Gly 
    770                 775                 780                 


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
785                 790                 795                 800 


Glu Tyr Phe Gln Ile Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                805                 810                 815     


Leu Ser Leu Val Glu Leu Phe Leu Ser Asp Val Glu Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
        835                 840                 845             


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
    850                 855                 860                 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
865                 870                 875                 880 


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
                885                 890                 895     


Lys Ile Asn Glu Asp Cys Lys Leu Pro Arg Trp His Met Asn Asp Phe 
            900                 905                 910         


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
        915                 920                 925             


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu 
    930                 935                 940                 


Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
945                 950                 955                 960 


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr 
                965                 970                 975     


Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Ala 
            980                 985                 990         


Arg Ile Lys Thr Gly Ile Asn Tyr  Val Lys Gln Thr Leu  Arg Glu Phe 
        995                 1000                 1005             


Val Leu  Lys Ala Phe Ser Lys  Lys Pro Lys Ile Ser  Lys Glu Ile 
    1010                 1015                 1020             


Arg Gln  Thr Glu Asp Leu Asn  Cys Lys Lys Glu Asn  Tyr Ile Ser 
    1025                 1030                 1035             


Asn Arg  Thr Leu Ala Glu Met  Ser Lys Asp His Asn  Phe His Lys 
    1040                 1045                 1050             


Glu Lys  Asp Lys Thr Ser Gly  Phe Gly Asn Asn Met  Asp Lys Tyr 
    1055                 1060                 1065             


Leu Met  Glu Glu Ser Asp Gly  Gln Ser Phe Ile His  Asn Pro Ser 
    1070                 1075                 1080             


Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly Glu Ser  Asp Leu Glu 
    1085                 1090                 1095             


Ile Met  Asn Thr Glu Glu Leu  Ser Ser Asp Ser Asp  Ser Glu Tyr 
    1100                 1105                 1110             


Ser Lys  Gly Arg Leu Asn Gln  Ser Ser Ser Ser Glu  Cys Ser Thr 
    1115                 1120                 1125             


Val Asp  Asn Pro Val Pro Gly  Glu Gly Glu Glu Ala  Glu Ala Glu 
    1130                 1135                 1140             


Pro Val  Asn Ser Asp Glu Pro  Glu Ala Cys Phe Thr  Asp Gly Cys 
    1145                 1150                 1155             


Val Gln  Arg Phe Pro Cys Cys  Gln Val Asn Ile Glu  Ser Gly Lys 
    1160                 1165                 1170             


Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr Cys Phe  Arg Ile Val 
    1175                 1180                 1185             


Glu His  Ser Trp Phe Glu Ser  Phe Ile Val Leu Met  Ile Leu Leu 
    1190                 1195                 1200             


Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile Tyr Ile  Glu Lys Lys 
    1205                 1210                 1215             


Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala Asp Lys  Ile Phe Thr 
    1220                 1225                 1230             


Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys Trp Val  Ala Tyr Gly 
    1235                 1240                 1245             


Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys Trp Leu  Asp Phe Leu 
    1250                 1255                 1260             


Ile Val  Asp Val Ser Leu Val  Thr Leu Val Ala Asn  Thr Leu Gly 
    1265                 1270                 1275             


Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu Arg Thr  Leu Arg Ala 
    1280                 1285                 1290             


Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe Glu Gly  Met Arg Val 
    1295                 1300                 1305             


Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro Ser Ile  Met Asn Val 
    1310                 1315                 1320             


Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile Phe Ser  Ile Met Gly 
    1325                 1330                 1335             


Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu Cys Ile  Asn Thr Thr 
    1340                 1345                 1350             


Asn Gly  Leu Arg Phe Pro Thr  Asn Glu Val Glu Asn  Arg Ser Ala 
    1355                 1360                 1365             


Cys Leu  Ala Leu Met Asn Val  Ser Gln Asn Val Arg  Trp Lys Asn 
    1370                 1375                 1380             


Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu Gly Tyr  Leu Ser Leu 
    1385                 1390                 1395             


Leu Gln  Val Ala Thr Phe Lys  Gly Trp Met Asp Ile  Met Tyr Ala 
    1400                 1405                 1410             


Ala Val  Asp Ser Val Asn Val  Asp Lys Gln Pro Ile  Tyr Glu Tyr 
    1415                 1420                 1425             


Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Ile Phe Ile  Ile Phe Gly 
    1430                 1435                 1440             


Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly Val Ile  Ile Asp Asn 
    1445                 1450                 1455             


Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly Gln Asp  Ile Phe Met 
    1460                 1465                 1470             


Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala Met Lys  Lys Leu Gly 
    1475                 1480                 1485             


Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg Pro Gly  Asn Lys Phe 
    1490                 1495                 1500             


Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn Gln Ala  Phe Asp Ile 
    1505                 1510                 1515             


Ala Ile  Met Val Leu Ile Cys  Leu Asn Met Val Thr  Met Met Val 
    1520                 1525                 1530             


Glu Lys  Glu Gly Gln Ser Glu  Tyr Met Thr Glu Val  Leu Tyr Trp 
    1535                 1540                 1545             


Ile Asn  Val Val Phe Ile Ile  Leu Phe Ser Gly Glu  Cys Val Leu 
    1550                 1555                 1560             


Lys Leu  Ile Ser Leu Arg Cys  Tyr Tyr Phe Thr Val  Gly Trp Asn 
    1565                 1570                 1575             


Ile Phe  Asp Phe Val Val Val  Ile Leu Ser Ile Val  Gly Met Phe 
    1580                 1585                 1590             


Leu Ala  Asp Leu Ile Glu Arg  Tyr Phe Val Ser Pro  Thr Leu Phe 
    1595                 1600                 1605             


Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg Ile Leu  Arg Leu Ile 
    1610                 1615                 1620             


Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu Phe Ala  Leu Met Met 
    1625                 1630                 1635             


Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu Leu Leu  Phe Leu Val 
    1640                 1645                 1650             


Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser Asn Phe  Ala Tyr Val 
    1655                 1660                 1665             


Lys Lys  Glu Ala Gly Ile Asn  Asp Met Phe Asn Phe  Glu Thr Phe 
    1670                 1675                 1680             


Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile Thr Thr  Ser Ala Gly 
    1685                 1690                 1695             


Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn Ser Ala  Pro Pro Asp 
    1700                 1705                 1710             


Cys Asp  Pro Lys Lys Val His  Pro Gly Ser Ser Val  Glu Gly Asp 
    1715                 1720                 1725             


Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr Phe Val  Ser Tyr Ile 
    1730                 1735                 1740             


Ile Ile  Ser Phe Leu Val Val  Val Asn Met Tyr Ile  Ala Val Ile 
    1745                 1750                 1755             


Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu Ser Thr  Glu Pro Leu 
    1760                 1765                 1770             


Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu Val Trp  Glu Lys Phe 
    1775                 1780                 1785             


Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Tyr Ser Lys  Leu Ser Asp 
    1790                 1795                 1800             


Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu Ile Ala  Lys Pro Asn 
    1805                 1810                 1815             


Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro Met Val  Ser Gly Asp 
    1820                 1825                 1830             


Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala Phe Thr  Lys Arg Val 
    1835                 1840                 1845             


Leu Gly  Glu Gly Gly Glu Met  Asp Ser Leu Arg Ser  Gln Met Glu 
    1850                 1855                 1860             


Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys Val Ser  Tyr Glu Pro 
    1865                 1870                 1875             


Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu Asp Val  Ser Ala Thr 
    1880                 1885                 1890             


Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg Leu Arg  Gln His Val 
    1895                 1900                 1905             


Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp Gly Asp  Arg Asp Asp 
    1910                 1915                 1920             


Asp Leu  Pro Asn Lys Glu His  Met Val Phe Asp Asn  Val Asn Glu 
    1925                 1930                 1935             


Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr Pro Ser  Thr Val Ser 
    1940                 1945                 1950             


Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro Asp Arg  Glu Lys Tyr 
    1955                 1960                 1965             


Glu Lys  Asp Lys Thr Glu Lys  Glu Asp Lys Gly Lys  Asp Gly Lys 
    1970                 1975                 1980             


Glu Gly  Lys Lys 
    1985         


<210>  35
<211>  1981
<212>  PRT
<213>  Camelus dromedarius

<400>  35

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val Tyr Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Gly Lys Thr 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Ala Pro Ala Leu Tyr Leu Leu Ser Pro Phe 
            100                 105                 110         


Asn Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Leu Ser Ser Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Val Trp Thr Pro Phe Glu Asn Asn Glu Thr Ile Glu Ser 
        275                 280                 285             


Met Leu Asp Ser Leu Asp Glu Glu Asp Arg Ser Lys Tyr Phe Tyr Tyr 
    290                 295                 300                 


Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser 
305                 310                 315                 320 


Gly Gln Cys Pro Glu Gly Tyr Thr Cys Met Lys Ile Gly Arg Asn Pro 
                325                 330                 335     


Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala 
            340                 345                 350         


Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Gln 
        355                 360                 365             


Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Val 
    370                 375                 380                 


Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val 
385                 390                 395                 400 


Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala Arg 
                405                 410                 415     


Gln Lys Glu Ile Glu Phe Gln Gln Met Leu Asp His Leu Lys Lys Glu 
            420                 425                 430         


Gln Glu Glu Ala Glu Ala Ile Ala Met Ala Ala Ala Glu Tyr Thr Ser 
        435                 440                 445             


Ile Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu Thr 
    450                 455                 460                 


Ser Arg Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys 
465                 470                 475                 480 


Lys Arg Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asp 
                485                 490                 495     


Glu Lys Leu Ser Lys Ser Glu Ser Glu Glu Asn Ile Arg Arg Lys Ser 
            500                 505                 510         


Phe Arg Leu Gly Val Glu Gly Pro Trp Arg Ala His Glu Lys Arg Leu 
        515                 520                 525             


Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
    530                 535                 540                 


Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
545                 550                 555                 560 


Lys Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                565                 570                 575     


Phe Gly Asp Ser Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
            580                 585                 590         


Pro Arg Glu Arg Arg Ser Ser Ser Ile Ser Gln Ala Ser Arg Ser Pro 
        595                 600                 605             


Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
    610                 615                 620                 


Gly Val Val Ser Leu Val Asp Gly Pro Ala Ala Leu Met Leu Pro Asn 
625                 630                 635                 640 


Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                645                 650                 655     


Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Pro Ser Ser Tyr 
            660                 665                 670         


Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Lys Arg Ala 
        675                 680                 685             


Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
    690                 695                 700                 


Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
705                 710                 715                 720 


Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Val Ile 
                725                 730                 735     


Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
            740                 745                 750         


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
        755                 760                 765             


Asp Glu Phe Lys Asn Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly 
    770                 775                 780                 


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
785                 790                 795                 800 


Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                805                 810                 815     


Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
        835                 840                 845             


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
    850                 855                 860                 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
865                 870                 875                 880 


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Arg Glu Cys Val Cys 
                885                 890                 895     


Lys Ile Ser Glu Glu Cys Thr Leu Pro Arg Trp His Met Asn Asp Ser 
            900                 905                 910         


Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met 
        915                 920                 925             


Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val Tyr 
    930                 935                 940                 


Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu 
945                 950                 955                 960 


Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr Ala Ile Glu 
                965                 970                 975     


Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Ala Arg Ile Lys 
            980                 985                 990         


Lys Gly Ile Asn Tyr Val Lys Gln  Thr Leu His Glu Phe  Ile Leu Lys 
        995                 1000                 1005             


Ala Phe  Ser Lys Lys Pro Lys  Val Ser Lys Glu Ile  Arg Arg Ala 
    1010                 1015                 1020             


Asp Leu  Asn Cys Lys Lys Glu  Asn Phe Ile Ser Asn  Arg Thr Leu 
    1025                 1030                 1035             


Ala Glu  Met Ser Lys Asp His  His Phe His Lys Glu  Lys Asp Lys 
    1040                 1045                 1050             


Thr Ser  Gly Phe Gly Asn Ser  Val Asp Lys Tyr Leu  Met Glu Glu 
    1055                 1060                 1065             


Ser Asp  Gly Gln Ser Phe Ile  His Asn Pro Ser Leu  Thr Val Thr 
    1070                 1075                 1080             


Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu Glu Ile  Met Asn Thr 
    1085                 1090                 1095             


Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu Tyr Ser  Lys Gly Arg 
    1100                 1105                 1110             


Leu Asn  Arg Ser Ser Ser Ser  Glu Cys Ser Thr Val  Asp Asn Ala 
    1115                 1120                 1125             


Leu Pro  Glu Lys Glu Ala Glu  Ala Glu Pro Val Asn  Pro Asp Glu 
    1130                 1135                 1140             


Pro Ala  Ala Cys Phe Thr Asp  Gly Cys Val Arg Arg  Phe Pro Cys 
    1145                 1150                 1155             


Cys Gln  Val Asn Ile Glu Ser  Gly Lys Gly Arg Ile  Trp Trp Asn 
    1160                 1165                 1170             


Ile Arg  Lys Thr Cys Tyr Arg  Ile Val Glu His Ser  Trp Phe Glu 
    1175                 1180                 1185             


Ser Phe  Ile Val Leu Met Ile  Leu Leu Ser Ser Gly  Ala Leu Ala 
    1190                 1195                 1200             


Phe Glu  Asp Ile Tyr Ile Glu  Lys Lys Arg Thr Ile  Lys Thr Ile 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Asp Lys Ile  Phe Thr Tyr Ile Phe  Ile Leu Glu 
    1220                 1225                 1230             


Met Leu  Leu Lys Trp Val Ala  Tyr Gly Tyr Lys Ile  Tyr Phe Thr 
    1235                 1240                 1245             


Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile Val Asp  Val Ser Leu 
    1250                 1255                 1260             


Val Thr  Leu Val Ala Ala Ala  Phe Gly Tyr Ser Asp  Leu Gly Pro 
    1265                 1270                 1275             


Ile Arg  Ser Leu Arg Thr Leu  Arg Ala Leu Arg Pro  Leu Arg Ala 
    1280                 1285                 1290             


Leu Ser  Arg Phe Glu Gly Met  Arg Val Val Val Asn  Ala Leu Ile 
    1295                 1300                 1305             


Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu Leu Val  Cys Leu Ile 
    1310                 1315                 1320             


Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val Asn Leu  Phe Ala Gly 
    1325                 1330                 1335             


Lys Phe  Tyr Glu Cys Ile Asn  Thr Thr Asp Gly Ser  Arg Phe His 
    1340                 1345                 1350             


Thr Asn  Arg Val Glu Asn Arg  Ser Glu Cys Phe Ala  Leu Met Asn 
    1355                 1360                 1365             


Val Ser  Gln Asn Val Arg Trp  Lys Asn Leu Lys Val  Asn Phe Asp 
    1370                 1375                 1380             


Asn Val  Gly Leu Gly Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe 
    1385                 1390                 1395             


Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala Val Asp  Ser Val Asn 
    1400                 1405                 1410             


Val Asp  Lys Gln Pro Ile Tyr  Glu Tyr Asn Leu Tyr  Met Tyr Ile 
    1415                 1420                 1425             


Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn 
    1430                 1435                 1440             


Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys 
    1445                 1450                 1455             


Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys 
    1460                 1465                 1470             


Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys 
    1475                 1480                 1485             


Pro Ile  Pro Arg Pro Gly Asn  Lys Phe Gln Gly Cys  Ile Phe Asp 
    1490                 1495                 1500             


Leu Val  Thr Asn Gln Ala Phe  Asp Ile Thr Ile Met  Val Leu Ile 
    1505                 1510                 1515             


Cys Leu  Asn Met Val Thr Met  Met Val Glu Lys Glu  Gly Gln Ser 
    1520                 1525                 1530             


Glu Tyr  Met Thr Glu Val Leu  Tyr Trp Ile Asn Val  Val Phe Ile 
    1535                 1540                 1545             


Ile Leu  Phe Thr Gly Glu Phe  Val Leu Lys Leu Ile  Ser Leu Arg 
    1550                 1555                 1560             


Cys Tyr  Tyr Phe Thr Val Gly  Trp Asn Ile Phe Asp  Phe Val Val 
    1565                 1570                 1575             


Val Ile  Leu Ser Ile Val Gly  Met Phe Leu Ala Asp  Leu Ile Glu 
    1580                 1585                 1590             


Lys Tyr  Phe Val Ser Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala 
    1595                 1600                 1605             


Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Lys Gly Ala  Lys Gly Ile 
    1610                 1615                 1620             


Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe 
    1625                 1630                 1635             


Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met Phe Ile  Tyr Ala Ile 
    1640                 1645                 1650             


Phe Gly  Met Ser Asn Phe Ala  Tyr Val Lys Lys Glu  Ala Gly Ile 
    1655                 1660                 1665             


Asn Asp  Met Phe Asn Phe Glu  Thr Phe Gly Asn Ser  Met Ile Cys 
    1670                 1675                 1680             


Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Ala 
    1685                 1690                 1695             


Pro Ile  Leu Asn Ser Gly Pro  Pro Asp Cys Asp Pro  Lys Lys Val 
    1700                 1705                 1710             


His Pro  Gly Ser Ser Val Glu  Gly Asp Cys Gly Asn  Pro Ser Val 
    1715                 1720                 1725             


Gly Ile  Phe Tyr Phe Val Ser  Tyr Ile Ile Ile Ser  Phe Leu Val 
    1730                 1735                 1740             


Val Val  Asn Met Tyr Ile Ala  Val Ile Leu Glu Asn  Phe Ser Val 
    1745                 1750                 1755             


Ala Thr  Glu Glu Ser Thr Glu  Pro Leu Ser Glu Asp  Asp Phe Glu 
    1760                 1765                 1770             


Met Phe  Tyr Glu Val Trp Glu  Lys Phe Asp Pro Asp  Ala Thr Gln 
    1775                 1780                 1785             


Phe Ile  Glu Tyr Ser Lys Leu  Ser Asp Phe Ala Ala  Ala Leu Asp 
    1790                 1795                 1800             


Pro Pro  Leu Leu Ile Ala Lys  Pro Asn Lys Val Gln  Leu Ile Ala 
    1805                 1810                 1815             


Met Asp  Leu Pro Met Val Ser  Gly Asp Arg Ile His  Cys Leu Asp 
    1820                 1825                 1830             


Ile Leu  Phe Ala Phe Thr Lys  Arg Val Leu Gly Glu  Ser Gly Glu 
    1835                 1840                 1845             


Met Asp  Ser Leu Arg Leu Gln  Met Glu Glu Arg Phe  Met Ser Ala 
    1850                 1855                 1860             


Asn Pro  Ser Lys Val Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys 
    1865                 1870                 1875             


Arg Lys  Gln Glu Asp Val Ser  Ala Thr Val Ile Gln  Arg Ala Tyr 
    1880                 1885                 1890             


Arg Arg  Tyr Arg Leu Arg Gln  Asn Val Lys Asn Ile  Ser Ser Ile 
    1895                 1900                 1905             


Tyr Ile  Lys Asp Gly Gly Lys  Asp Asp Asp Leu Pro  Lys Lys Glu 
    1910                 1915                 1920             


Asp Thr  Val Phe Asp Asn Val  Asn Gly Asn Ser Ser  Pro Glu Lys 
    1925                 1930                 1935             


Thr Asp  Ala Thr Ser Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser 
    1940                 1945                 1950             


Val Thr  Lys Pro Asp Lys Glu  Lys Tyr Glu Lys Asp  Lys Thr Glu 
    1955                 1960                 1965             


Lys Glu  Asp Lys Gly Lys Asp  Gly Lys Glu Ser Lys  Lys 
    1970                 1975                 1980     


<210>  36
<211>  1987
<212>  PRT
<213>  Orcinus orca

<400>  36

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val Tyr Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Gly Lys Thr 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Gln Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Ile Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Ala Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Ile Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


Gln Lys Cys Val Arg Thr Leu Leu Glu Asn Asn Glu Thr Ile Glu Ser 
        275                 280                 285             


Ile Leu Asn Thr Leu Asp Glu Glu Asp Tyr Gly Lys Tyr Phe Tyr Tyr 
    290                 295                 300                 


Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser 
305                 310                 315                 320 


Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Val Gly Lys Asn Pro 
                325                 330                 335     


Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala 
            340                 345                 350         


Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Gln 
        355                 360                 365             


Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Val 
    370                 375                 380                 


Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val 
385                 390                 395                 400 


Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala Arg 
                405                 410                 415     


Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys Glu 
            420                 425                 430         


Gln Glu Glu Ala Glu Ala Ile Ala Met Ala Ala Ala Glu Tyr Thr Ser 
        435                 440                 445             


Ile Glu Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu Thr 
    450                 455                 460                 


Ser Lys Met Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys 
465                 470                 475                 480 


Lys Asn Asn Gln Lys Lys Leu Ser Ile Gly Glu Glu Lys Gly Asp Asp 
                485                 490                 495     


Glu Lys Leu Ser Lys Ser Glu Ser Glu Glu Ser Ile Arg Arg Lys Ser 
            500                 505                 510         


Phe His Leu Gly Val Glu Gly His Arg Arg Ala Arg Glu Lys Arg Phe 
        515                 520                 525             


Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile His Gly Ser Leu Phe Ser 
    530                 535                 540                 


Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
545                 550                 555                 560 


Lys Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                565                 570                 575     


Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
            580                 585                 590         


Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
        595                 600                 605             


Pro Gly Leu Pro Val Asn Arg Lys Met His Ser Ala Val Asp Cys Asn 
    610                 615                 620                 


Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
625                 630                 635                 640 


Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                645                 650                 655     


Ser Gly Thr Asn Asn Gln Ile His Lys Lys Arg Arg Ser Ser Ser Tyr 
            660                 665                 670         


Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg Ala 
        675                 680                 685             


Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
    690                 695                 700                 


Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
705                 710                 715                 720 


Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Arg Leu Ile 
                725                 730                 735     


Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
            740                 745                 750         


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
        755                 760                 765             


Asp Glu Phe Lys Asn Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly 
    770                 775                 780                 


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
785                 790                 795                 800 


Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                805                 810                 815     


Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
        835                 840                 845             


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
    850                 855                 860                 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
865                 870                 875                 880 


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
                885                 890                 895     


Lys Ile Asn Glu Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe 
            900                 905                 910         


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
        915                 920                 925             


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu 
    930                 935                 940                 


Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
945                 950                 955                 960 


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr 
                965                 970                 975     


Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Thr Ala Val Ala 
            980                 985                 990         


Arg Ile Lys Lys Gly Ile Asn Tyr  Val Lys Gln Thr Leu  Arg Glu Phe 
        995                 1000                 1005             


Phe Leu  Lys Gly Phe Ser Thr  Lys Pro Lys Ile Ser  Lys Glu Ile 
    1010                 1015                 1020             


Arg Arg  Thr Glu Asp Leu Asn  Tyr Lys Lys Glu Asn  Tyr Ile Ser 
    1025                 1030                 1035             


Asn His  Thr Leu Ala Glu Met  Ser Lys Asp His Asn  Phe His Lys 
    1040                 1045                 1050             


Glu Lys  Asp Lys Thr Ser Gly  Phe Gly Asn Ser Met  Asp Lys Tyr 
    1055                 1060                 1065             


Leu Val  Glu Glu Ser Asp Gly  Gln Ser Phe Ile His  Asn Ala Ser 
    1070                 1075                 1080             


Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly Glu Ser  Asp Leu Glu 
    1085                 1090                 1095             


Ile Met  Asn Thr Glu Glu Leu  Ser Ser Asp Ser Asp  Ser Glu Tyr 
    1100                 1105                 1110             


Ser Lys  Gly Arg Leu Asn Gly  Ser Ser Ser Ser Glu  Cys Ser Thr 
    1115                 1120                 1125             


Val Asp  Asn Pro Val Pro Gly  Glu Gly Glu Glu Ala  Glu Ala Glu 
    1130                 1135                 1140             


Pro Val  Asn Ser Asp Glu Pro  Glu Ala Cys Phe Thr  Asp Gly Cys 
    1145                 1150                 1155             


Val Gln  Arg Leu Pro Cys Cys  Gln Val Asn Thr Glu  Ser Gly Lys 
    1160                 1165                 1170             


Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr Cys Tyr  Arg Ile Val 
    1175                 1180                 1185             


Glu His  Ser Trp Phe Glu Ser  Phe Ile Val Leu Met  Ile Leu Leu 
    1190                 1195                 1200             


Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile Tyr Ile  Glu Lys Lys 
    1205                 1210                 1215             


Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala Asp Lys  Ile Phe Thr 
    1220                 1225                 1230             


Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys Trp Ile  Ala Tyr Gly 
    1235                 1240                 1245             


Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys Trp Leu  Asp Phe Leu 
    1250                 1255                 1260             


Ile Val  Asp Val Ser Leu Val  Thr Leu Val Ala Asn  Thr Leu Gly 
    1265                 1270                 1275             


Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu Arg Thr  Leu Arg Ala 
    1280                 1285                 1290             


Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe Glu Gly  Met Arg Val 
    1295                 1300                 1305             


Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro Ser Ile  Met Asn Val 
    1310                 1315                 1320             


Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile Phe Ser  Ile Met Gly 
    1325                 1330                 1335             


Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Gln Cys Val  Asn Thr Thr 
    1340                 1345                 1350             


Asp Gly  Ser Pro Phe Pro Thr  Ser Glu Val Glu Asn  Arg Ser Glu 
    1355                 1360                 1365             


Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn Val Gln  Trp Lys Asn 
    1370                 1375                 1380             


Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu Gly Tyr  Leu Ser Leu 
    1385                 1390                 1395             


Leu Gln  Val Ala Thr Phe Lys  Gly Trp Met Val Ile  Met Tyr Ala 
    1400                 1405                 1410             


Ala Val  Asp Ser Val Asn Val  Asp Arg Gln Pro Ile  Tyr Glu Tyr 
    1415                 1420                 1425             


Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Ile Phe Ile  Ile Phe Gly 
    1430                 1435                 1440             


Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly Val Ile  Ile Asp Asn 
    1445                 1450                 1455             


Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly Gln Asp  Ile Phe Met 
    1460                 1465                 1470             


Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala Met Lys  Lys Leu Gly 
    1475                 1480                 1485             


Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg Pro Gly  Asn Lys Phe 
    1490                 1495                 1500             


Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn Gln Ala  Phe Asp Ile 
    1505                 1510                 1515             


Ala Ile  Met Val Leu Ile Cys  Leu Asn Met Val Thr  Met Met Val 
    1520                 1525                 1530             


Glu Lys  Glu Gly Gln Ser Ala  Tyr Met Thr Glu Val  Leu Tyr Trp 
    1535                 1540                 1545             


Ile Asn  Val Val Phe Val Ile  Leu Phe Thr Gly Glu  Cys Val Leu 
    1550                 1555                 1560             


Lys Leu  Ile Ser Leu Arg Cys  Tyr Tyr Phe Thr Val  Gly Trp Asn 
    1565                 1570                 1575             


Ile Phe  Asp Phe Val Val Val  Ile Leu Ser Ile Val  Gly Met Phe 
    1580                 1585                 1590             


Leu Ala  Asp Leu Ile Glu Arg  Tyr Phe Val Ser Pro  Thr Leu Phe 
    1595                 1600                 1605             


Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg Ile Leu  Arg Leu Ile 
    1610                 1615                 1620             


Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu Phe Ala  Leu Met Met 
    1625                 1630                 1635             


Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu Leu Leu  Phe Leu Val 
    1640                 1645                 1650             


Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser Asn Phe  Ala Tyr Val 
    1655                 1660                 1665             


Lys Lys  Glu Ala Gly Ile Asn  Asp Met Phe Asn Phe  Glu Thr Phe 
    1670                 1675                 1680             


Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile Thr Thr  Ser Ala Gly 
    1685                 1690                 1695             


Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn Ser Ala  Pro Pro Asp 
    1700                 1705                 1710             


Cys Asp  Pro Arg Lys Val His  Pro Gly Ser Ser Val  Glu Gly Asp 
    1715                 1720                 1725             


Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr Phe Val  Ser Tyr Ile 
    1730                 1735                 1740             


Ile Ile  Ser Phe Leu Val Val  Val Asn Met Tyr Ile  Ala Val Ile 
    1745                 1750                 1755             


Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu Ser Thr  Glu Pro Leu 
    1760                 1765                 1770             


Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu Val Trp  Glu Lys Phe 
    1775                 1780                 1785             


Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Tyr Ser Lys  Leu Ser Asp 
    1790                 1795                 1800             


Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu Val Ala  Lys Pro Asn 
    1805                 1810                 1815             


Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro Met Val  Ser Gly Asp 
    1820                 1825                 1830             


Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala Phe Thr  Lys Arg Val 
    1835                 1840                 1845             


Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu Arg Ser  Gln Met Glu 
    1850                 1855                 1860             


Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys Val Ser  Tyr Glu Pro 
    1865                 1870                 1875             


Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu Asp Val  Ser Ala Thr 
    1880                 1885                 1890             


Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg Leu Arg  Gln Asn Val 
    1895                 1900                 1905             


Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp Gly Asp  Arg Asp Asp 
    1910                 1915                 1920             


Asp Leu  Pro Asn Lys Glu Asp  Met Val Phe Asp Asn  Val Asn Glu 
    1925                 1930                 1935             


Asn Ser  Ser Pro Glu Lys Thr  Asp Gly Thr Pro Ser  Thr Ile Ser 
    1940                 1945                 1950             


Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro Asp Lys  Glu Lys Tyr 
    1955                 1960                 1965             


Glu Lys  Asp Lys Thr Glu Lys  Glu Asp Lys Gly Lys  Asp Gly Lys 
    1970                 1975                 1980             


Glu Gly  Lys Lys 
    1985         


<210>  37
<211>  1975
<212>  PRT
<213>  Equus caballus

<400>  37

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val Tyr Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Arg Ile Glu Gln Arg Ile Ala Glu Gly Lys Thr 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Arg 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Ile Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Ile Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Leu Arg Asn Pro Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asp Thr Leu Glu Glu Glu Asp Phe Arg Lys Tyr Phe Tyr Tyr 
    290                 295                 300                 


Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser 
305                 310                 315                 320 


Gly Gln Cys Pro Glu Gly Tyr Ile Cys Val Lys Ala Gly Arg Asn Pro 
                325                 330                 335     


Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala 
            340                 345                 350         


Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Gln 
        355                 360                 365             


Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Val 
    370                 375                 380                 


Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val 
385                 390                 395                 400 


Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala Arg 
                405                 410                 415     


Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys Glu 
            420                 425                 430         


Gln Glu Glu Ala Glu Ala Ile Ala Met Ala Ala Ala Glu Tyr Thr Ser 
        435                 440                 445             


Ile Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu Thr 
    450                 455                 460                 


Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Arg 
465                 470                 475                 480 


Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asp 
                485                 490                 495     


Glu Lys Leu Ser Lys Ser Glu Ser Glu Glu Ser Ile Arg Arg Lys Ser 
            500                 505                 510         


Phe His Leu Gly Ile Glu Gly His Arg Arg Ala His Glu Lys Arg Leu 
        515                 520                 525             


Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
    530                 535                 540                 


Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
545                 550                 555                 560 


Lys Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                565                 570                 575     


Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
            580                 585                 590         


Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
        595                 600                 605             


Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
    610                 615                 620                 


Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
625                 630                 635                 640 


Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys Arg 
                645                 650                 655     


Arg Ser Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn 
            660                 665                 670         


Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val 
        675                 680                 685             


Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg 
    690                 695                 700                 


Phe Ala His Thr Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys 
705                 710                 715                 720 


Phe Lys Lys Leu Ile His Phe Ile Val Met Asp Pro Phe Val Asp Leu 
                725                 730                 735     


Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu 
            740                 745                 750         


His His Pro Met Thr Asp Glu Phe Lys Asn Val Leu Thr Val Gly Asn 
        755                 760                 765             


Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile 
    770                 775                 780                 


Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp 
785                 790                 795                 800 


Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val 
                805                 810                 815     


Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys 
            820                 825                 830         


Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly 
        835                 840                 845             


Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile 
    850                 855                 860                 


Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr 
865                 870                 875                 880 


Lys Glu Cys Val Cys Lys Ile Asn Glu Asp Cys Glu Leu Pro Arg Trp 
                885                 890                 895     


His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu 
            900                 905                 910         


Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly 
        915                 920                 925             


Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn 
    930                 935                 940                 


Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser 
945                 950                 955                 960 


Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Thr Asp Thr Asn Asn Leu 
                965                 970                 975     


Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys Gln 
            980                 985                 990         


Thr Leu Arg Glu Phe Ile Leu Lys  Ala Phe Ser Lys Lys  Pro Lys Ile 
        995                 1000                 1005             


Ser Lys  Glu Ile Arg Arg Ala  Asp Leu Asn Ser Lys  Lys Glu Asn 
    1010                 1015                 1020             


Tyr Ile  Ser Asn Arg Thr Leu  Ala Glu Met Ser Lys  Asp His Asn 
    1025                 1030                 1035             


Phe His  Lys Asp Lys Asp Lys  Thr Gly Gly Phe Arg  Ser Ser Val 
    1040                 1045                 1050             


Asp Lys  Tyr Leu Met Glu Glu  Ser Asp Cys Gln Ser  Phe Ile His 
    1055                 1060                 1065             


Asn Pro  Ser Leu Thr Val Thr  Val Pro Ile Ala Pro  Gly Glu Ser 
    1070                 1075                 1080             


Asp Leu  Glu Asn Met Asn Thr  Glu Glu Leu Ser Ser  Asp Ser Glu 
    1085                 1090                 1095             


Ser Glu  Tyr Ser Lys Gly Arg  Leu Asn Gln Ser Ser  Ser Ser Glu 
    1100                 1105                 1110             


Cys Ser  Thr Val Asp Asn Pro  Leu Pro Gly Glu Gly  Glu Glu Ala 
    1115                 1120                 1125             


Glu Ala  Glu Pro Val Asn Ser  Asp Glu Pro Glu Ala  Cys Phe Thr 
    1130                 1135                 1140             


Asp Gly  Cys Val Gln Arg Phe  Pro Cys Cys Gln Val  Asn Ile Glu 
    1145                 1150                 1155             


Ser Glu  Lys Gly Lys Ile Trp  Trp Asn Ile Arg Lys  Thr Cys Tyr 
    1160                 1165                 1170             


Arg Ile  Val Glu His Ser Trp  Phe Glu Ser Phe Ile  Val Leu Met 
    1175                 1180                 1185             


Ile Leu  Leu Ser Ser Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile 
    1190                 1195                 1200             


Glu Lys  Lys Lys Asn Ile Lys  Ile Ile Leu Glu Tyr  Ala Asp Lys 
    1205                 1210                 1215             


Ile Phe  Thr Tyr Val Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val 
    1220                 1225                 1230             


Ala Tyr  Gly Tyr Lys Thr Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu 
    1235                 1240                 1245             


Asp Phe  Leu Ile Val Asp Val  Ser Leu Val Thr Leu  Val Ala Asn 
    1250                 1255                 1260             


Thr Leu  Gly Tyr Ser Asp Leu  Gly Pro Ile Lys Ser  Leu Arg Thr 
    1265                 1270                 1275             


Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly 
    1280                 1285                 1290             


Met Arg  Val Val Val Asn Ala  Leu Ile Gly Ala Ile  Pro Ser Ile 
    1295                 1300                 1305             


Met Asn  Val Leu Leu Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser 
    1310                 1315                 1320             


Ile Met  Gly Val Asn Leu Phe  Ala Gly Lys Phe Tyr  Gln Cys Val 
    1325                 1330                 1335             


Asn Thr  Thr Asp Gly Ser Arg  Phe Leu Thr Asn Glu  Val Gln Asn 
    1340                 1345                 1350             


Arg Ser  Asp Cys Phe Ala Leu  Met Asn Val Ser Gln  Asn Val Arg 
    1355                 1360                 1365             


Trp Lys  Asn Leu Lys Val Asn  Phe Asp Asn Val Gly  Leu Gly Tyr 
    1370                 1375                 1380             


Leu Ser  Leu Leu Gln Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile 
    1385                 1390                 1395             


Met Tyr  Ala Ala Val Asp Ser  Val Asn Val Asp Lys  Gln Pro Ile 
    1400                 1405                 1410             


Tyr Glu  Tyr Ser Leu Tyr Met  Tyr Ile Tyr Phe Val  Ile Phe Ile 
    1415                 1420                 1425             


Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile 
    1430                 1435                 1440             


Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys Leu Gly  Gly Gln Asp 
    1445                 1450                 1455             


Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys 
    1460                 1465                 1470             


Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Gly 
    1475                 1480                 1485             


Asn Lys  Phe Gln Gly Cys Ile  Phe Asp Leu Val Thr  Asn Gln Ala 
    1490                 1495                 1500             


Phe Asp  Ile Ser Ile Met Val  Leu Ile Cys Leu Asn  Met Val Thr 
    1505                 1510                 1515             


Met Met  Val Glu Lys Glu Gly  Gln Ser Asp Tyr Met  Thr Asp Val 
    1520                 1525                 1530             


Leu Tyr  Trp Ile Asn Val Val  Phe Ile Ile Leu Phe  Thr Gly Glu 
    1535                 1540                 1545             


Cys Val  Leu Lys Leu Val Ser  Leu Arg His Tyr Tyr  Phe Thr Val 
    1550                 1555                 1560             


Gly Trp  Asn Ile Phe Asp Phe  Val Val Val Ile Leu  Ser Ile Val 
    1565                 1570                 1575             


Gly Met  Phe Leu Ala Asp Leu  Ile Glu Lys Tyr Phe  Val Ser Pro 
    1580                 1585                 1590             


Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu 
    1595                 1600                 1605             


Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala 
    1610                 1615                 1620             


Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu 
    1625                 1630                 1635             


Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe 
    1640                 1645                 1650             


Ala Tyr  Val Lys Lys Glu Ala  Gly Ile Asn Asp Met  Phe Asn Phe 
    1655                 1660                 1665             


Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr 
    1670                 1675                 1680             


Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Ala 
    1685                 1690                 1695             


Pro Pro  Asp Cys Asp Pro Arg  Lys Val His Pro Gly  Ser Ser Val 
    1700                 1705                 1710             


Glu Gly  Asp Cys Gly Asn Pro  Ser Val Gly Ile Phe  Tyr Phe Val 
    1715                 1720                 1725             


Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val Val Asn  Met Tyr Ile 
    1730                 1735                 1740             


Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr 
    1745                 1750                 1755             


Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp 
    1760                 1765                 1770             


Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe Ile Glu  Phe Ser Lys 
    1775                 1780                 1785             


Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala 
    1790                 1795                 1800             


Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met Asp Leu  Pro Met Val 
    1805                 1810                 1815             


Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr 
    1820                 1825                 1830             


Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ser  Leu Arg Ser 
    1835                 1840                 1845             


Gln Met  Glu Glu Arg Phe Met  Ser Ala Asn Pro Ser  Lys Val Ser 
    1850                 1855                 1860             


Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg Lys Gln  Glu Asp Val 
    1865                 1870                 1875             


Ser Ala  Thr Val Ile Gln Arg  Ala Tyr Arg Arg Tyr  Arg Leu Arg 
    1880                 1885                 1890             


Gln Asn  Val Lys Asn Ile Ser  Ser Ile Tyr Ile Lys  Asp Gly Glu 
    1895                 1900                 1905             


Arg Asp  Asp Asp Leu Pro Ser  Lys Lys Asp Met Val  Phe Asp Asn 
    1910                 1915                 1920             


Val Asn  Glu Asn Ser Ser Thr  Glu Lys Thr Asp Ala  Thr Pro Ser 
    1925                 1930                 1935             


Thr Val  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Asp Lys 
    1940                 1945                 1950             


Glu Lys  Tyr Glu Lys Asp Lys  Thr Glu Lys Glu Asp  Lys Glu Lys 
    1955                 1960                 1965             


Asp Gly  Lys Glu Ser Lys Lys  
    1970                 1975 


<210>  38
<211>  1986
<212>  PRT
<213>  Canis lupus

<400>  38

Met Ala Thr Leu Pro Pro Pro Gly Pro Gln Ser Phe Val Tyr Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Gly Lys Thr 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Gly Pro Arg 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Leu Arg Asp Pro Leu Asp Asp Asn Glu Thr Leu Thr Ser 
        275                 280                 285             


Leu Leu Asp Thr Leu Glu Glu Glu Asp Tyr Lys Lys Tyr Phe Tyr Tyr 
    290                 295                 300                 


Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Leu Ser Thr Asp Ser 
305                 310                 315                 320 


Gly Gln Cys Pro Glu Gly Tyr Lys Cys Val Lys Ala Gly Arg Asn Pro 
                325                 330                 335     


Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala 
            340                 345                 350         


Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Gln 
        355                 360                 365             


Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Val 
    370                 375                 380                 


Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val 
385                 390                 395                 400 


Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala Arg 
                405                 410                 415     


Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys Glu 
            420                 425                 430         


Gln Glu Glu Ala Glu Ala Ile Ala Ile Ala Ala Ala Glu Tyr Thr Ser 
        435                 440                 445             


Ile Gly Arg Ser Arg Met Met Gly Phe Ser Glu Ser Ser Ser Glu Thr 
    450                 455                 460                 


Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys 
465                 470                 475                 480 


Lys Arg Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asn 
                485                 490                 495     


Glu Lys Leu Ser Lys Ser Glu Ser Glu Glu Ser Ile Arg Arg Gln Ser 
            500                 505                 510         


Phe His Leu Gly Val Glu Gly His Arg Arg Ala Arg Glu Lys Arg Leu 
        515                 520                 525             


Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
    530                 535                 540                 


Gly Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
545                 550                 555                 560 


Lys Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                565                 570                 575     


Phe Gly Asp Ser Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
            580                 585                 590         


Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
        595                 600                 605             


Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
    610                 615                 620                 


Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
625                 630                 635                 640 


Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                645                 650                 655     


Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Ser Ser Ser Tyr 
            660                 665                 670         


Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg Ala 
        675                 680                 685             


Met Ser Arg Val Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
    690                 695                 700                 


Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
705                 710                 715                 720 


Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Leu Val 
                725                 730                 735     


Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
            740                 745                 750         


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
        755                 760                 765             


Asp Glu Phe Lys Asn Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly 
    770                 775                 780                 


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
785                 790                 795                 800 


Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                805                 810                 815     


Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
        835                 840                 845             


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
    850                 855                 860                 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
865                 870                 875                 880 


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
                885                 890                 895     


Lys Ile Asn Glu Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe 
            900                 905                 910         


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
        915                 920                 925             


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu 
    930                 935                 940                 


Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
945                 950                 955                 960 


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr 
                965                 970                 975     


Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Ala 
            980                 985                 990         


Arg Ile Lys Lys Gly Val Asn Tyr  Val Lys Gln Thr Leu  Arg Glu Phe 
        995                 1000                 1005             


Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys Ile Ser  Lys Asp Thr 
    1010                 1015                 1020             


Arg Arg  Ala Glu Asp Gln Asn  Ser Lys Lys Glu Asn  Cys Ile Ser 
    1025                 1030                 1035             


Asn Arg  Thr Leu Ala Glu Met  Asn Lys Asp His Asn  Phe His Lys 
    1040                 1045                 1050             


Glu Lys  Glu Lys Ile Ser Gly  Phe Gly Ser Ser Met  Asp Lys Tyr 
    1055                 1060                 1065             


Leu Met  Glu Glu Ser Asp Cys  Gln Ser Phe Ile His  Asn Pro Ser 
    1070                 1075                 1080             


Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly Glu Ser  Asp Leu Glu 
    1085                 1090                 1095             


Asn Met  Asn Thr Glu Glu Leu  Ser Ser Asp Ser Asp  Ser Glu Tyr 
    1100                 1105                 1110             


Ser Lys  Gly Arg Leu Asn Arg  Ser Ser Ser Ser Glu  Cys Ser Thr 
    1115                 1120                 1125             


Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu Glu Ala  Glu Ala Glu 
    1130                 1135                 1140             


Pro Val  Asn Ser Asp Glu Pro  Glu Ala Cys Phe Thr  Asp Gly Cys 
    1145                 1150                 1155             


Val Arg  Arg Phe Pro Cys Cys  Gln Val Asp Ile Glu  Ser Gly Lys 
    1160                 1165                 1170             


Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr Cys Tyr  Arg Ile Val 
    1175                 1180                 1185             


Glu His  Ser Trp Phe Glu Ser  Phe Ile Val Leu Met  Ile Leu Leu 
    1190                 1195                 1200             


Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile Tyr Ile  Glu Lys Lys 
    1205                 1210                 1215             


Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala Asp Lys  Ile Phe Thr 
    1220                 1225                 1230             


Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys Trp Val  Ala Tyr Gly 
    1235                 1240                 1245             


Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys Trp Leu  Asp Phe Leu 
    1250                 1255                 1260             


Ile Val  Asp Val Ser Leu Val  Thr Leu Val Ala Asn  Thr Leu Gly 
    1265                 1270                 1275             


Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu Arg Thr  Leu Arg Ala 
    1280                 1285                 1290             


Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe Glu Gly  Met Arg Val 
    1295                 1300                 1305             


Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro Ser Ile  Met Asn Val 
    1310                 1315                 1320             


Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile Phe Ser  Ile Met Gly 
    1325                 1330                 1335             


Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu Cys Val  Asn Thr Thr 
    1340                 1345                 1350             


Asp Gly  Ser Arg Phe Pro Thr  Asn Leu Val Gln Asn  His Ser Asp 
    1355                 1360                 1365             


Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn Val Arg  Trp Lys Asn 
    1370                 1375                 1380             


Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu Gly Tyr  Leu Ser Leu 
    1385                 1390                 1395             


Leu Gln  Val Ala Thr Phe Lys  Gly Trp Met Asp Ile  Met Tyr Ala 
    1400                 1405                 1410             


Ala Val  Asp Ser Val Asn Val  Asp Lys Gln Pro Ile  Tyr Glu Tyr 
    1415                 1420                 1425             


Asn Leu  Tyr Met Tyr Ile Tyr  Phe Val Ile Phe Ile  Ile Phe Gly 
    1430                 1435                 1440             


Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly Val Ile  Ile Asp Asn 
    1445                 1450                 1455             


Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly Gln Asp  Ile Phe Met 
    1460                 1465                 1470             


Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala Met Lys  Lys Leu Gly 
    1475                 1480                 1485             


Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg Pro Gly  Asn Lys Phe 
    1490                 1495                 1500             


Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn Gln Val  Phe Asp Ile 
    1505                 1510                 1515             


Thr Ile  Met Val Leu Ile Cys  Leu Asn Met Val Thr  Met Met Val 
    1520                 1525                 1530             


Glu Lys  Glu Gly Gln Ser Lys  Tyr Met Thr Asp Val  Leu Tyr Trp 
    1535                 1540                 1545             


Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr Gly Glu  Cys Val Leu 
    1550                 1555                 1560             


Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe Thr Val  Gly Trp Asn 
    1565                 1570                 1575             


Ile Phe  Asp Phe Val Val Val  Ile Leu Ser Ile Val  Gly Met Phe 
    1580                 1585                 1590             


Leu Ala  Glu Leu Ile Glu Lys  Tyr Phe Val Ser Pro  Thr Leu Phe 
    1595                 1600                 1605             


Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg Ile Leu  Arg Leu Ile 
    1610                 1615                 1620             


Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu Phe Ala  Leu Met Met 
    1625                 1630                 1635             


Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu Leu Leu  Phe Leu Val 
    1640                 1645                 1650             


Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser Asn Phe  Ala Tyr Val 
    1655                 1660                 1665             


Lys Lys  Glu Ala Gly Ile Asn  Asp Met Phe Asn Phe  Glu Thr Phe 
    1670                 1675                 1680             


Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile Thr Thr  Ser Ala Gly 
    1685                 1690                 1695             


Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn Ser Ala  Pro Pro Asp 
    1700                 1705                 1710             


Cys Asp  Pro Lys Lys Val His  Pro Gly Ser Ser Val  Glu Gly Asp 
    1715                 1720                 1725             


Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr Phe Val  Ser Tyr Ile 
    1730                 1735                 1740             


Ile Ile  Ser Phe Leu Val Val  Val Asn Met Tyr Ile  Ala Val Ile 
    1745                 1750                 1755             


Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu Ser Thr  Glu Pro Leu 
    1760                 1765                 1770             


Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu Val Trp  Glu Lys Phe 
    1775                 1780                 1785             


Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Tyr Ser Lys  Leu Ser Asp 
    1790                 1795                 1800             


Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu Ile Ala  Lys Pro Asn 
    1805                 1810                 1815             


Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro Met Val  Ser Gly Asp 
    1820                 1825                 1830             


Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala Phe Thr  Lys Arg Val 
    1835                 1840                 1845             


Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu Arg Ser  Gln Met Glu 
    1850                 1855                 1860             


Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys Val Ser  Tyr Glu Pro 
    1865                 1870                 1875             


Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu Asp Val  Ser Ala Thr 
    1880                 1885                 1890             


Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg Leu Arg  Gln Asn Val 
    1895                 1900                 1905             


Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp Gly Asp  Arg Asp Asp 
    1910                 1915                 1920             


Asp Leu  Pro Asn Lys Glu Asp  Met Val Phe Asp Asn  Ile Glu Asn 
    1925                 1930                 1935             


Ser Ser  Pro Glu Lys Thr Asp  Ala Thr Pro Ser Thr  Val Ser Pro 
    1940                 1945                 1950             


Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Asp Lys Glu  Lys Tyr Glu 
    1955                 1960                 1965             


Lys Asp  Lys Thr Glu Lys Glu  Asp Lys Gly Lys Asp  Gly Lys Glu 
    1970                 1975                 1980             


Ser Lys  Lys 
    1985     


<210>  39
<211>  1984
<212>  PRT
<213>  Rattus norvegicus

<400>  39

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ser Glu Glu Lys Ala 
            20                  25                  30          


Lys Glu His Lys Asp Glu Lys Lys Asp Asp Glu Glu Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Leu Ser Asn Pro Pro Glu Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Lys Glu Leu Glu Glu Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Ala Glu Ser Glu Glu Glu Leu Lys Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Ile Cys Val Lys Ala Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Phe Thr 
        435                 440                 445             


Ser Ile Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Arg Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Lys Gln Lys Met Ser Ser Gly Glu Glu Lys Gly Asp Asp 
                485                 490                 495     


Glu Lys Leu Ser Lys Ser Gly Ser Glu Glu Ser Ile Arg Lys Lys Ser 
            500                 505                 510         


Phe His Leu Gly Val Glu Gly His His Arg Thr Arg Glu Lys Arg Leu 
        515                 520                 525             


Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
    530                 535                 540                 


Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
545                 550                 555                 560 


Arg Asp Leu Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                565                 570                 575     


Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
            580                 585                 590         


Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
        595                 600                 605             


Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
    610                 615                 620                 


Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
625                 630                 635                 640 


Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                645                 650                 655     


Ser Gly Thr Thr Asn Gln Met Arg Lys Lys Arg Leu Ser Ser Ser Tyr 
            660                 665                 670         


Phe Leu Ser Glu Asp Met Leu Asn Asp Pro His Leu Arg Gln Arg Ala 
        675                 680                 685             


Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
    690                 695                 700                 


Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
705                 710                 715                 720 


Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Leu Ile 
                725                 730                 735     


Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
            740                 745                 750         


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
        755                 760                 765             


Glu Glu Phe Lys Asn Val Leu Ala Val Gly Asn Leu Ile Phe Thr Gly 
    770                 775                 780                 


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
785                 790                 795                 800 


Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                805                 810                 815     


Leu Ser Leu Ile Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
        835                 840                 845             


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
    850                 855                 860                 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
865                 870                 875                 880 


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
                885                 890                 895     


Lys Ile Asn Val Asp Cys Lys Leu Pro Arg Trp His Met Asn Asp Phe 
            900                 905                 910         


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
        915                 920                 925             


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
    930                 935                 940                 


Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
945                 950                 955                 960 


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr 
                965                 970                 975     


Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Ala 
            980                 985                 990         


Arg Ile Lys Arg Gly Ile Asn Tyr  Val Lys Gln Thr Leu  Arg Glu Phe 
        995                 1000                 1005             


Ile Leu  Lys Ser Phe Ser Lys  Lys Pro Lys Gly Ser  Lys Asp Thr 
    1010                 1015                 1020             


Lys Arg  Thr Ala Asp Pro Asn  Asn Lys Lys Glu Asn  Tyr Ile Ser 
    1025                 1030                 1035             


Asn Arg  Thr Leu Ala Glu Met  Ser Lys Asp His Asn  Phe Leu Lys 
    1040                 1045                 1050             


Glu Lys  Asp Arg Ile Ser Gly  Tyr Gly Ser Ser Leu  Asp Lys Ser 
    1055                 1060                 1065             


Phe Met  Asp Glu Asn Asp Tyr  Gln Ser Phe Ile His  Asn Pro Ser 
    1070                 1075                 1080             


Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly Glu Ser  Asp Leu Glu 
    1085                 1090                 1095             


Ile Met  Asn Thr Glu Glu Leu  Ser Ser Asp Ser Asp  Ser Asp Tyr 
    1100                 1105                 1110             


Ser Lys  Glu Lys Arg Asn Arg  Ser Ser Ser Ser Glu  Cys Ser Thr 
    1115                 1120                 1125             


Val Asp  Asn Pro Leu Pro Gly  Glu Glu Glu Ala Glu  Ala Glu Pro 
    1130                 1135                 1140             


Val Asn  Ala Asp Glu Pro Glu  Ala Cys Phe Thr Asp  Gly Cys Val 
    1145                 1150                 1155             


Arg Arg  Phe Pro Cys Cys Gln  Val Asn Val Asp Ser  Gly Lys Gly 
    1160                 1165                 1170             


Lys Val  Trp Trp Thr Ile Arg  Lys Thr Cys Tyr Arg  Ile Val Glu 
    1175                 1180                 1185             


His Ser  Trp Phe Glu Ser Phe  Ile Val Leu Met Ile  Leu Leu Ser 
    1190                 1195                 1200             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Ile Glu  Lys Lys Lys 
    1205                 1210                 1215             


Thr Ile  Lys Ile Ile Leu Glu  Tyr Ala Asp Lys Ile  Phe Thr Tyr 
    1220                 1225                 1230             


Ile Phe  Ile Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Tyr 
    1235                 1240                 1245             


Lys Thr  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1250                 1255                 1260             


Val Asp  Val Ser Leu Val Thr  Leu Val Ala Asn Thr  Leu Gly Tyr 
    1265                 1270                 1275             


Ser Asp  Leu Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1280                 1285                 1290             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1295                 1300                 1305             


Val Asn  Ala Leu Ile Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1310                 1315                 1320             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1325                 1330                 1335             


Asn Leu  Phe Ala Gly Lys Phe  Tyr Glu Cys Val Asn  Thr Thr Asp 
    1340                 1345                 1350             


Gly Ser  Arg Phe Pro Thr Ser  Gln Val Ala Asn Arg  Ser Glu Cys 
    1355                 1360                 1365             


Phe Ala  Leu Met Asn Val Ser  Gly Asn Val Arg Trp  Lys Asn Leu 
    1370                 1375                 1380             


Lys Val  Asn Phe Asp Asn Val  Gly Leu Gly Tyr Leu  Ser Leu Leu 
    1385                 1390                 1395             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1400                 1405                 1410             


Val Asp  Ser Val Asn Val Asn  Glu Gln Pro Lys Tyr  Glu Tyr Ser 
    1415                 1420                 1425             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1430                 1435                 1440             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1445                 1450                 1455             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1460                 1465                 1470             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1475                 1480                 1485             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Gly Asn  Lys Phe Gln 
    1490                 1495                 1500             


Gly Cys  Ile Phe Asp Leu Val  Thr Asn Gln Ala Phe  Asp Ile Thr 
    1505                 1510                 1515             


Ile Met  Val Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1520                 1525                 1530             


Lys Glu  Gly Gln Thr Glu Tyr  Met Asp Tyr Val Leu  His Trp Ile 
    1535                 1540                 1545             


Asn Met  Val Phe Ile Ile Leu  Phe Thr Gly Glu Cys  Val Leu Lys 
    1550                 1555                 1560             


Leu Ile  Ser Leu Arg His Tyr  Tyr Phe Thr Val Gly  Trp Asn Ile 
    1565                 1570                 1575             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Met Phe Leu 
    1580                 1585                 1590             


Ala Glu  Met Ile Glu Lys Tyr  Phe Val Ser Pro Thr  Leu Phe Arg 
    1595                 1600                 1605             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Lys 
    1610                 1615                 1620             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1625                 1630                 1635             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1640                 1645                 1650             


Phe Ile  Tyr Ala Ile Phe Gly  Met Ser Asn Phe Ala  Tyr Val Lys 
    1655                 1660                 1665             


Lys Glu  Ala Gly Ile Asn Asp  Met Phe Asn Phe Glu  Thr Phe Gly 
    1670                 1675                 1680             


Asn Ser  Met Ile Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1685                 1690                 1695             


Asp Gly  Leu Leu Ala Pro Ile  Leu Asn Ser Ala Pro  Pro Asp Cys 
    1700                 1705                 1710             


Asp Pro  Lys Lys Val His Pro  Gly Ser Ser Val Glu  Gly Asp Cys 
    1715                 1720                 1725             


Gly Asn  Pro Ser Val Gly Ile  Phe Tyr Phe Val Ser  Tyr Ile Ile 
    1730                 1735                 1740             


Ile Ser  Phe Leu Val Val Val  Asn Met Tyr Ile Ala  Val Ile Leu 
    1745                 1750                 1755             


Glu Asn  Phe Ser Val Ala Thr  Glu Glu Ser Thr Glu  Pro Leu Ser 
    1760                 1765                 1770             


Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Val Trp Glu  Lys Phe Asp 
    1775                 1780                 1785             


Pro Asp  Ala Thr Gln Phe Ile  Glu Phe Cys Lys Leu  Ser Asp Phe 
    1790                 1795                 1800             


Ala Ala  Ala Leu Asp Pro Pro  Leu Leu Ile Ala Lys  Pro Asn Lys 
    1805                 1810                 1815             


Val Gln  Leu Ile Ala Met Asp  Leu Pro Met Val Ser  Gly Asp Arg 
    1820                 1825                 1830             


Ile His  Cys Leu Asp Ile Leu  Phe Ala Phe Thr Lys  Arg Val Leu 
    1835                 1840                 1845             


Gly Glu  Gly Gly Glu Met Asp  Ser Leu Arg Ser Gln  Met Glu Glu 
    1850                 1855                 1860             


Arg Phe  Met Ser Ala Asn Pro  Ser Lys Val Ser Tyr  Glu Pro Ile 
    1865                 1870                 1875             


Thr Thr  Thr Leu Lys Arg Lys  Gln Glu Glu Val Ser  Ala Thr Ile 
    1880                 1885                 1890             


Ile Gln  Arg Ala Tyr Arg Arg  Tyr Arg Leu Arg Gln  His Val Lys 
    1895                 1900                 1905             


Asn Ile  Ser Ser Ile Tyr Ile  Lys Asp Gly Asp Arg  Asp Asp Asp 
    1910                 1915                 1920             


Leu Pro  Asn Lys Glu Asp Thr  Val Phe Asp Asn Val  Asn Glu Asn 
    1925                 1930                 1935             


Ser Ser  Pro Glu Lys Thr Asp  Val Thr Ala Ser Thr  Ile Ser Pro 
    1940                 1945                 1950             


Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Asp Gln Glu  Lys Tyr Glu 
    1955                 1960                 1965             


Thr Asp  Lys Thr Glu Lys Glu  Asp Lys Glu Lys Asp  Glu Ser Arg 
    1970                 1975                 1980             


Lys 
    


<210>  40
<211>  1984
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  40

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val Arg Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Gly Lys Thr 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp His Asp Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Ala Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Ile Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Ala Glu Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Phe Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Ile Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Ile Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly His Leu Lys 
            260                 265                 270         


His Lys Cys Leu Arg Lys Ile Glu Asn Glu Thr Leu Glu Ser Ile Met 
        275                 280                 285             


Ser Ser Ile Glu Ser Glu Glu Asp Tyr Lys Lys Tyr Phe Tyr Tyr Leu 
    290                 295                 300                 


Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser Gly 
305                 310                 315                 320 


Gln Cys Pro Glu Gly Tyr Tyr Cys Val Lys Ala Gly Arg Asn Pro Asp 
                325                 330                 335     


Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu 
            340                 345                 350         


Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Gln Thr 
        355                 360                 365             


Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Val Ile 
    370                 375                 380                 


Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala 
385                 390                 395                 400 


Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala Lys Gln 
                405                 410                 415     


Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys Glu Gln 
            420                 425                 430         


Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr Ser Ile 
        435                 440                 445             


Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu Thr Ser 
    450                 455                 460                 


Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys Lys 
465                 470                 475                 480 


Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asp Glu 
                485                 490                 495     


Lys Leu Ser Lys Ser Glu Ser Glu Glu Ser Ile Ser Arg Lys Gln Phe 
            500                 505                 510         


His Leu Gly Val Glu Gly His Arg Leu Ala Arg Glu Lys Arg Leu Ser 
        515                 520                 525             


Ala Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser Ala 
    530                 535                 540                 


Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly Lys 
545                 550                 555                 560 


Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile Phe 
                565                 570                 575     


Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro Gln Arg Pro 
            580                 585                 590         


Gln Glu Arg Arg Ser Ser Asn Leu Ser Gln Ala Ser Arg Ser Pro Pro 
        595                 600                 605             


Met Leu Gln Met Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly 
    610                 615                 620                 


Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn Gly 
625                 630                 635                 640 


Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp Ser 
                645                 650                 655     


Gly Thr Thr Gln Ile Arg Lys Lys Arg Arg Ser Ser Ser Tyr Leu Leu 
            660                 665                 670         


Ser Glu Asp Met Leu Asn Asp Pro His Leu Arg Gln Arg Ala Met Ser 
        675                 680                 685             


Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg 
    690                 695                 700                 


Gln Lys Cys Pro Ser Trp Trp Tyr Arg Phe Ala His Thr Phe Leu Ile 
705                 710                 715                 720 


Trp Asn Cys Ser Pro Phe Trp Ile Lys Phe Lys Lys Phe Ile Tyr Ile 
                725                 730                 735     


Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val 
            740                 745                 750         


Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr Glu Glu 
        755                 760                 765             


Phe Lys Asn Val Leu Val Val Gly Asn Leu Val Phe Thr Gly Ile Phe 
    770                 775                 780                 


Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr 
785                 790                 795                 800 


Phe Gln Val Gly Trp Asn Val Phe Asp Ser Leu Ile Val Thr Leu Ser 
                805                 810                 815     


Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val Leu Arg 
            820                 825                 830         


Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr 
        835                 840                 845             


Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Pro Leu Gly 
    850                 855                 860                 


Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val 
865                 870                 875                 880 


Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile 
                885                 890                 895     


Asn Asp Asp Cys Ser Leu Pro Arg Trp His Met Asn Asp Phe Phe His 
            900                 905                 910         


Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr 
        915                 920                 925             


Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val 
    930                 935                 940                 


Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe 
945                 950                 955                 960 


Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ser Ala Ile 
                965                 970                 975     


Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Thr Arg Ile 
            980                 985                 990         


Lys Lys Gly Ile Asn Tyr Val Lys  Gln Thr Leu Arg Glu  Leu Ile Leu 
        995                 1000                 1005             


Lys Ala  Phe Ser Lys Lys Pro  Lys Ile Ser Lys Glu  Ile Arg Gln 
    1010                 1015                 1020             


Ala Glu  Asp Leu Asn Ser Lys  Lys Glu Asn Tyr Ile  Ser Asn Arg 
    1025                 1030                 1035             


Thr Leu  Ala Glu Met Ser Lys  Asp Tyr Asn Phe His  Lys Glu Lys 
    1040                 1045                 1050             


Asp Lys  Ile Ser Gly Phe Gly  Ser Ser Met Asp Lys  Tyr Leu Met 
    1055                 1060                 1065             


Glu Glu  Ser Asp His Gln Ser  Phe Ile His Asn Pro  Ser Leu Thr 
    1070                 1075                 1080             


Val Thr  Val Pro Ile Ala Pro  Gly Glu Ser Asp Leu  Glu Asn Met 
    1085                 1090                 1095             


Asn Thr  Glu Glu Leu Ser Ser  Asp Ser Glu Ser Glu  Tyr Ser Lys 
    1100                 1105                 1110             


Glu Arg  Leu Asn Arg Ser Ser  Ser Ser Glu Cys Ser  Thr Val Asp 
    1115                 1120                 1125             


Asn Ala  Leu Pro Gly Glu Gly  Glu Glu Ala Glu Ala  Glu Pro Val 
    1130                 1135                 1140             


Asn Ser  Asp Glu Pro Glu Ala  Cys Phe Thr Asp Gly  Cys Val Arg 
    1145                 1150                 1155             


Arg Phe  Pro Cys Cys Gln Val  Ser Ile Glu Ser Gly  Lys Gly Lys 
    1160                 1165                 1170             


Ile Trp  Trp Asn Ile Arg Lys  Thr Cys Tyr Arg Ile  Val Glu His 
    1175                 1180                 1185             


Ser Trp  Phe Glu Ser Phe Ile  Val Leu Met Ile Leu  Leu Ser Ser 
    1190                 1195                 1200             


Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile Glu Lys  Lys Lys Thr 
    1205                 1210                 1215             


Ile Lys  Ile Ile Leu Glu Tyr  Ala Asp Lys Ile Phe  Thr Tyr Ile 
    1220                 1225                 1230             


Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val Ala Tyr  Gly Tyr Lys 
    1235                 1240                 1245             


Thr Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu Asp Phe  Leu Ile Val 
    1250                 1255                 1260             


Asp Val  Ser Leu Val Thr Leu  Val Ala Asn Thr Leu  Gly Tyr Ser 
    1265                 1270                 1275             


Asp Leu  Gly Pro Ile Lys Ser  Leu Arg Thr Leu Arg  Ala Leu Arg 
    1280                 1285                 1290             


Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly Met Arg  Val Val Val 
    1295                 1300                 1305             


Asn Ala  Leu Ile Gly Ala Ile  Pro Ser Ile Met Asn  Val Leu Leu 
    1310                 1315                 1320             


Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser Ile Met  Gly Val Asn 
    1325                 1330                 1335             


Leu Phe  Ala Gly Lys Phe Tyr  Gln Cys Val Asn Thr  Thr Asp Asp 
    1340                 1345                 1350             


Ser Arg  Phe Pro Thr Lys Gln  Val Ser Asn Arg Ser  Glu Cys Phe 
    1355                 1360                 1365             


Ala Leu  Met Asn Gly Ser Gln  Asn Val Arg Trp Lys  Asn Leu Lys 
    1370                 1375                 1380             


Val Asn  Phe Asp Asn Val Gly  Leu Arg Tyr Leu Ser  Leu Leu Gln 
    1385                 1390                 1395             


Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val 
    1400                 1405                 1410             


Asp Ser  Val Asn Val Asp Gln  Gln Pro Ser Tyr Glu  His Asn Leu 
    1415                 1420                 1425             


Tyr Met  Tyr Ile Tyr Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe 
    1430                 1435                 1440             


Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn 
    1445                 1450                 1455             


Gln Gln  Lys Lys Lys Leu Gly  Gly Gln Asp Ile Phe  Met Thr Glu 
    1460                 1465                 1470             


Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys 
    1475                 1480                 1485             


Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Gly Asn Lys  Phe Gln Gly 
    1490                 1495                 1500             


Cys Ile  Phe Asp Leu Val Thr  Asn Gln Ala Phe Asp  Ile Thr Ile 
    1505                 1510                 1515             


Met Ile  Leu Ile Cys Leu Asn  Met Val Thr Met Met  Val Glu Lys 
    1520                 1525                 1530             


Glu Gly  Gln Ser Asp Tyr Met  Thr Asp Val Leu Tyr  Trp Ile Asn 
    1535                 1540                 1545             


Val Val  Phe Ile Ile Leu Phe  Thr Gly Glu Cys Val  Leu Lys Leu 
    1550                 1555                 1560             


Ile Ser  Leu Arg His Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe 
    1565                 1570                 1575             


Asp Phe  Val Val Val Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala 
    1580                 1585                 1590             


Glu Leu  Ile Glu Thr Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val 
    1595                 1600                 1605             


Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly 
    1610                 1615                 1620             


Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu 
    1625                 1630                 1635             


Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe 
    1640                 1645                 1650             


Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe Ala Tyr  Val Lys Lys 
    1655                 1660                 1665             


Glu Ala  Gly Ile Asn Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn 
    1670                 1675                 1680             


Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp 
    1685                 1690                 1695             


Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Ala Pro Pro  Asp Cys Asp 
    1700                 1705                 1710             


Pro Lys  Lys Val His Pro Gly  Ser Ser Thr Glu Gly  Asp Cys Gly 
    1715                 1720                 1725             


Ser Pro  Ser Val Gly Ile Phe  Tyr Phe Val Ser Tyr  Ile Ile Ile 
    1730                 1735                 1740             


Ser Phe  Leu Val Val Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu 
    1745                 1750                 1755             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1760                 1765                 1770             


Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp Glu Lys  Phe Asp Pro 
    1775                 1780                 1785             


Asp Ala  Thr Gln Phe Ile Glu  Tyr Ser Lys Leu Ser  Asp Phe Ala 
    1790                 1795                 1800             


Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala Lys Pro  Asn Lys Val 
    1805                 1810                 1815             


Gln Leu  Ile Ala Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1820                 1825                 1830             


His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1835                 1840                 1845             


Glu Ser  Gly Glu Met Asp Ser  Leu Arg Ser Gln Met  Glu Glu Arg 
    1850                 1855                 1860             


Phe Met  Ser Ala Asn Pro Ser  Lys Val Ser Tyr Glu  Pro Ile Thr 
    1865                 1870                 1875             


Thr Thr  Leu Lys Arg Lys Gln  Glu Asp Val Ser Ala  Thr Val Ile 
    1880                 1885                 1890             


Gln Arg  Ala Tyr Arg Arg Tyr  Arg Leu Arg Gln Asn  Val Lys Asn 
    1895                 1900                 1905             


Ile Ser  Ser Ile Tyr Ile Lys  Glu Gly Asp Lys Asp  Asp Asp Leu 
    1910                 1915                 1920             


Pro Asn  Lys Gly Asp Ile Val  Phe Asp Asn Val Asn  Ser Ser Ser 
    1925                 1930                 1935             


Pro Glu  Lys Thr Asp Ala Thr  Ala Ser Thr Ile Ser  Pro Pro Ser 
    1940                 1945                 1950             


Tyr Asp  Ser Val Thr Lys Pro  Asp Lys Glu Lys Tyr  Glu Lys Asp 
    1955                 1960                 1965             


Lys Thr  Glu Lys Glu Asp Lys  Gly Lys Asp Gly Lys  Glu Thr Lys 
    1970                 1975                 1980             


Lys 
    


<210>  41
<211>  1984
<212>  PRT
<213>  Gallus gallus

<400>  41

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val Arg Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Gly Lys Thr 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp His Asp Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Ala Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Ile Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Ala Glu Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Phe Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Ile Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Ile Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly His Leu Lys 
            260                 265                 270         


His Lys Cys Leu Arg Lys Ile Glu Asn Glu Thr Leu Glu Ser Ile Met 
        275                 280                 285             


Ser Ser Ile Glu Ser Glu Glu Asp Tyr Lys Lys Tyr Phe Tyr Tyr Leu 
    290                 295                 300                 


Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser Gly 
305                 310                 315                 320 


Gln Cys Pro Glu Gly Tyr Tyr Cys Val Lys Ala Gly Arg Asn Pro Asp 
                325                 330                 335     


Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu 
            340                 345                 350         


Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Gln Thr 
        355                 360                 365             


Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Val Ile 
    370                 375                 380                 


Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala 
385                 390                 395                 400 


Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala Lys Gln 
                405                 410                 415     


Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys Glu Gln 
            420                 425                 430         


Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr Ser Ile 
        435                 440                 445             


Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu Thr Ser 
    450                 455                 460                 


Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys Lys 
465                 470                 475                 480 


Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asp Glu 
                485                 490                 495     


Lys Leu Ser Lys Ser Glu Ser Glu Glu Ser Ile Ser Arg Lys Gln Phe 
            500                 505                 510         


His Leu Gly Val Glu Gly His Arg Leu Ala Arg Glu Lys Arg Leu Ser 
        515                 520                 525             


Ala Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser Ala 
    530                 535                 540                 


Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly Lys 
545                 550                 555                 560 


Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile Phe 
                565                 570                 575     


Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro Gln Arg Pro 
            580                 585                 590         


Gln Glu Arg Arg Ser Ser Asn Leu Ser Gln Ala Ser Arg Ser Pro Pro 
        595                 600                 605             


Met Leu Gln Met Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly 
    610                 615                 620                 


Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn Gly 
625                 630                 635                 640 


Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp Ser 
                645                 650                 655     


Gly Thr Thr Gln Ile Arg Lys Lys Arg Arg Ser Ser Ser Tyr Leu Leu 
            660                 665                 670         


Ser Glu Asp Met Leu Asn Asp Pro His Leu Arg Gln Arg Ala Met Ser 
        675                 680                 685             


Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg 
    690                 695                 700                 


Gln Lys Cys Pro Ser Trp Trp Tyr Arg Phe Ala His Thr Phe Leu Ile 
705                 710                 715                 720 


Trp Asn Cys Ser Pro Phe Trp Ile Lys Phe Lys Lys Phe Ile Tyr Ile 
                725                 730                 735     


Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val 
            740                 745                 750         


Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr Glu Glu 
        755                 760                 765             


Phe Lys Asn Val Leu Val Val Gly Asn Leu Val Phe Thr Gly Ile Phe 
    770                 775                 780                 


Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr 
785                 790                 795                 800 


Phe Gln Val Gly Trp Asn Val Phe Asp Ser Leu Ile Val Thr Leu Ser 
                805                 810                 815     


Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val Leu Arg 
            820                 825                 830         


Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr 
        835                 840                 845             


Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Pro Leu Gly 
    850                 855                 860                 


Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val 
865                 870                 875                 880 


Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile 
                885                 890                 895     


Asn Asp Asp Cys Ser Leu Pro Arg Trp His Met Asn Asp Phe Phe His 
            900                 905                 910         


Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr 
        915                 920                 925             


Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val 
    930                 935                 940                 


Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe 
945                 950                 955                 960 


Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ser Ala Ile 
                965                 970                 975     


Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Thr Arg Ile 
            980                 985                 990         


Lys Lys Gly Ile Asn Tyr Val Lys  Gln Thr Leu Arg Glu  Leu Ile Leu 
        995                 1000                 1005             


Lys Ala  Phe Ser Lys Lys Pro  Lys Ile Ser Lys Glu  Ile Arg Gln 
    1010                 1015                 1020             


Ala Glu  Asp Leu Asn Ser Lys  Lys Glu Asn Tyr Ile  Ser Asn Arg 
    1025                 1030                 1035             


Thr Leu  Ala Glu Met Ser Lys  Asp Tyr Asn Phe His  Lys Glu Lys 
    1040                 1045                 1050             


Asp Lys  Ile Ser Gly Phe Gly  Ser Ser Met Asp Lys  Tyr Leu Met 
    1055                 1060                 1065             


Glu Glu  Ser Asp His Gln Ser  Phe Ile His Asn Pro  Ser Leu Thr 
    1070                 1075                 1080             


Val Thr  Val Pro Ile Ala Pro  Gly Glu Ser Asp Leu  Glu Asn Met 
    1085                 1090                 1095             


Asn Thr  Glu Glu Leu Ser Ser  Asp Ser Glu Ser Glu  Tyr Ser Lys 
    1100                 1105                 1110             


Glu Arg  Leu Asn Arg Ser Ser  Ser Ser Glu Cys Ser  Thr Val Asp 
    1115                 1120                 1125             


Asn Ala  Leu Pro Gly Glu Gly  Glu Glu Ala Glu Ala  Glu Pro Val 
    1130                 1135                 1140             


Asn Ser  Asp Glu Pro Glu Ala  Cys Phe Thr Asp Gly  Cys Val Arg 
    1145                 1150                 1155             


Arg Phe  Pro Cys Cys Gln Val  Ser Ile Glu Ser Gly  Lys Gly Lys 
    1160                 1165                 1170             


Ile Trp  Trp Asn Ile Arg Lys  Thr Cys Tyr Arg Ile  Val Glu His 
    1175                 1180                 1185             


Ser Trp  Phe Glu Ser Phe Ile  Val Leu Met Ile Leu  Leu Ser Ser 
    1190                 1195                 1200             


Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile Glu Lys  Lys Lys Thr 
    1205                 1210                 1215             


Ile Lys  Ile Ile Leu Glu Tyr  Ala Asp Lys Ile Phe  Thr Tyr Ile 
    1220                 1225                 1230             


Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val Ala Tyr  Gly Tyr Lys 
    1235                 1240                 1245             


Thr Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu Asp Phe  Leu Ile Val 
    1250                 1255                 1260             


Asp Val  Ser Leu Val Thr Leu  Val Ala Asn Thr Leu  Gly Tyr Ser 
    1265                 1270                 1275             


Asp Leu  Gly Pro Ile Lys Ser  Leu Arg Thr Leu Arg  Ala Leu Arg 
    1280                 1285                 1290             


Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly Met Arg  Val Val Val 
    1295                 1300                 1305             


Asn Ala  Leu Ile Gly Ala Ile  Pro Ser Ile Met Asn  Val Leu Leu 
    1310                 1315                 1320             


Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser Ile Met  Gly Val Asn 
    1325                 1330                 1335             


Leu Phe  Ala Gly Lys Phe Tyr  Gln Cys Val Asn Thr  Thr Asp Asp 
    1340                 1345                 1350             


Ser Arg  Phe Pro Thr Lys Gln  Val Ser Asn Arg Ser  Glu Cys Phe 
    1355                 1360                 1365             


Ala Leu  Met Asn Gly Ser Gln  Asn Val Arg Trp Lys  Asn Leu Lys 
    1370                 1375                 1380             


Val Asn  Phe Asp Asn Val Gly  Leu Arg Tyr Leu Ser  Leu Leu Gln 
    1385                 1390                 1395             


Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val 
    1400                 1405                 1410             


Asp Ser  Val Asn Val Asp Gln  Gln Pro Ser Tyr Glu  His Asn Leu 
    1415                 1420                 1425             


Tyr Met  Tyr Ile Tyr Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe 
    1430                 1435                 1440             


Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn 
    1445                 1450                 1455             


Gln Gln  Lys Lys Lys Leu Gly  Gly Gln Asp Ile Phe  Met Thr Glu 
    1460                 1465                 1470             


Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys 
    1475                 1480                 1485             


Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Gly Asn Lys  Phe Gln Gly 
    1490                 1495                 1500             


Cys Ile  Phe Asp Leu Val Thr  Asn Gln Ala Phe Asp  Ile Thr Ile 
    1505                 1510                 1515             


Met Ile  Leu Ile Cys Leu Asn  Met Val Thr Met Met  Val Glu Lys 
    1520                 1525                 1530             


Glu Gly  Gln Ser Asp Tyr Met  Thr Asp Val Leu Tyr  Trp Ile Asn 
    1535                 1540                 1545             


Val Val  Phe Ile Ile Leu Phe  Thr Gly Glu Cys Val  Leu Lys Leu 
    1550                 1555                 1560             


Ile Ser  Leu Arg His Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe 
    1565                 1570                 1575             


Asp Phe  Val Val Val Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala 
    1580                 1585                 1590             


Glu Leu  Ile Glu Thr Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val 
    1595                 1600                 1605             


Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly 
    1610                 1615                 1620             


Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu 
    1625                 1630                 1635             


Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe 
    1640                 1645                 1650             


Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe Ala Tyr  Val Lys Lys 
    1655                 1660                 1665             


Glu Ala  Gly Ile Asn Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn 
    1670                 1675                 1680             


Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp 
    1685                 1690                 1695             


Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Ala Pro Pro  Asp Cys Asp 
    1700                 1705                 1710             


Pro Lys  Lys Val His Pro Gly  Ser Ser Thr Glu Gly  Asp Cys Gly 
    1715                 1720                 1725             


Ser Pro  Ser Val Gly Ile Phe  Tyr Phe Val Ser Tyr  Ile Ile Ile 
    1730                 1735                 1740             


Ser Phe  Leu Val Val Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu 
    1745                 1750                 1755             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1760                 1765                 1770             


Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp Glu Lys  Phe Asp Pro 
    1775                 1780                 1785             


Asp Ala  Thr Gln Phe Ile Glu  Tyr Ser Lys Leu Ser  Asp Phe Ala 
    1790                 1795                 1800             


Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala Lys Pro  Asn Lys Val 
    1805                 1810                 1815             


Gln Leu  Ile Ala Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1820                 1825                 1830             


His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1835                 1840                 1845             


Glu Ser  Gly Glu Met Asp Ser  Leu Arg Ser Gln Met  Glu Glu Arg 
    1850                 1855                 1860             


Phe Met  Ser Ala Asn Pro Ser  Lys Val Ser Tyr Glu  Pro Ile Thr 
    1865                 1870                 1875             


Thr Thr  Leu Lys Arg Lys Gln  Glu Asp Val Ser Ala  Thr Val Ile 
    1880                 1885                 1890             


Gln Arg  Ala Tyr Arg Arg Tyr  Arg Leu Arg Gln Asn  Val Lys Asn 
    1895                 1900                 1905             


Ile Ser  Ser Ile Tyr Ile Lys  Glu Gly Asp Lys Asp  Asp Asp Leu 
    1910                 1915                 1920             


Pro Asn  Lys Gly Asp Ile Val  Phe Asp Asn Val Asn  Ser Ser Ser 
    1925                 1930                 1935             


Pro Glu  Lys Thr Asp Ala Thr  Ala Ser Thr Ile Ser  Pro Pro Ser 
    1940                 1945                 1950             


Tyr Asp  Ser Val Thr Lys Pro  Asp Lys Glu Lys Tyr  Glu Lys Asp 
    1955                 1960                 1965             


Lys Thr  Glu Lys Glu Asp Lys  Gly Lys Asp Gly Lys  Glu Thr Lys 
    1970                 1975                 1980             


Lys 
    


<210>  42
<211>  1730
<212>  PRT
<213>  Ophiophagus hannah

<400>  42

Leu Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser 
1               5                   10                  15      


Asp Val Met Ile Leu Thr Leu Phe Cys Leu Ser Val Phe Ala Leu Ile 
            20                  25                  30          


Gly Leu Gln Leu Phe Met Gly His Leu Arg His Lys Cys Leu Leu Trp 
        35                  40                  45              


Pro Leu Ser Asn Thr Ser Tyr Lys Asp Pro Arg Phe Met Glu Tyr Tyr 
    50                  55                  60                  


Asn Gly Thr Glu Leu Met Trp Ser Lys Tyr Ile Glu Asn Lys Glu His 
65                  70                  75                  80  


Phe Tyr Phe Leu Glu Gly Ala Lys Asp Ala Leu Leu Cys Gly Asn Ser 
                85                  90                  95      


Thr Asp Ala Gly Gln Cys Pro Glu Gly Tyr Lys Cys Ile Pro Ala Gly 
            100                 105                 110         


Arg Asn Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Ser Phe Ser Trp Ala 
        115                 120                 125             


Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu 
    130                 135                 140                 


Tyr Gln Gln Thr Leu Arg Ala Ala Gly Lys Gly Tyr Met Phe Phe Phe 
145                 150                 155                 160 


Val Val Val Ile Phe Leu Gly Ser Phe Tyr Leu Val Asn Leu Ile Leu 
                165                 170                 175     


Ala Val Val Ala Met Ala Tyr Asp Glu Gln Asn Gln Ala Thr Ile Glu 
            180                 185                 190         


Glu Ala Leu Arg Lys Glu Thr Glu Tyr Gln Gln Met Leu Glu His Leu 
        195                 200                 205             


Lys Arg Gln Gln Glu Glu Ala Gln Ala Leu Ala Ala Ala Val Ala Cys 
    210                 215                 220                 


Lys Asp Phe Arg Asp Asp Gly Ala Leu Gly Arg Leu Ser Glu Thr Ser 
225                 230                 235                 240 


Ser Glu Leu Ser Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
                245                 250                 255     


Lys Lys Arg Arg Gln Arg Glu Leu Ser Val Gly Glu Pro Gly Gly Asn 
            260                 265                 270         


Ser Lys Met Phe Pro Lys Ser Glu Ser Asp Ser Ser Ile Arg Arg Lys 
        275                 280                 285             


Gly Phe Arg Phe Ser Leu Glu Gly Asn Arg Leu Thr Tyr Glu Asn Arg 
    290                 295                 300                 


Val Ile Ser Pro Tyr Gln Ser Met Leu Phe Pro Thr Arg Arg Asn Ser 
305                 310                 315                 320 


Arg Ala Ser Phe Ser Ser Phe Lys Gly Pro Thr Ala Glu Gly Ser Ser 
                325                 330                 335     


Asp Ala Asp Ser Glu His Ser Thr Phe Glu Glu Asn Gly Ser Arg Asn 
            340                 345                 350         


Gly Ser Tyr Phe Val Val Arg Arg His Ser Asp Arg Arg Ser Ser Asn 
        355                 360                 365             


Ile Ser Gln Thr Met Phe Pro Met Asn Gly Lys Met Gln Ser Ser Val 
    370                 375                 380                 


Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly Pro Pro Val Leu Leu 
385                 390                 395                 400 


Ser Pro Thr Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr 
                405                 410                 415     


Thr Asn Asp Asn Gly Thr Ala Ser Glu Met Glu Gly Lys Lys Arg Arg 
            420                 425                 430         


Ser Ser Ser Phe Gln Ile Ser Met Asp Leu Leu Glu Asp Pro Thr Ile 
        435                 440                 445             


Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Ile Thr Asn Thr Met Glu 
    450                 455                 460                 


Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe 
465                 470                 475                 480 


Ala His Ser Tyr Leu Ile Trp Asn Cys Ser Asp Arg Trp Leu Gln Ile 
                485                 490                 495     


Lys Arg Ile Ile His Leu Ile Val Met Asp Pro Phe Val Asp Leu Gly 
            500                 505                 510         


Ile Thr Ile Cys Ile Ile Leu Asn Thr Leu Phe Met Ser Met Glu His 
        515                 520                 525             


Tyr Pro Ile Asp Asp Ser Phe Ser Gly Val Leu Lys Asn Gly Asn Met 
    530                 535                 540                 


Val Phe Thr Gly Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala 
545                 550                 555                 560 


Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Ser 
                565                 570                 575     


Ile Ile Val Thr Leu Ser Leu Met Glu Leu Gly Leu Gln Asp Val Glu 
            580                 585                 590         


Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu 
        595                 600                 605             


Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn 
    610                 615                 620                 


Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val 
625                 630                 635                 640 


Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn Tyr Asp 
                645                 650                 655     


Ser Cys Lys Cys Lys Ile Ser Glu Asp Cys Lys Leu Pro Arg Trp His 
            660                 665                 670         


Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys 
        675                 680                 685             


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln 
    690                 695                 700                 


Ala Leu Cys Leu Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu 
705                 710                 715                 720 


Val Leu Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser 
                725                 730                 735     


Asp Ser Leu Ala Ala Pro Glu Gln Glu Thr Glu Ala Asn Asn Leu Gln 
            740                 745                 750         


Ile Ala Ile Ser Arg Ile Gln Arg Gly Ile Asn Tyr Ile Lys Arg Lys 
        755                 760                 765             


Ile Cys Glu Phe Val Gln Ile Val Phe Leu Gln Lys Cys Lys Gly Thr 
    770                 775                 780                 


Ser Gly Leu Ser Ala Ala Asp Gln Gln Asn Asn Lys Lys Asp Gln Cys 
785                 790                 795                 800 


Ile Pro Asn His Thr Val Val Glu Ile Asn Gln Thr Phe Gly Tyr Gln 
                805                 810                 815     


Lys Pro Lys Met Thr Thr Thr Cys Met Asp Asn Ser Asp His Met Ser 
            820                 825                 830         


Phe Ile Asn Asn Pro Asn Leu Thr Val Thr Val Pro Ile Ala Val Gly 
        835                 840                 845             


Glu Ser Asp Phe Glu His Phe Asn Thr Glu Glu Leu Thr Ser Ile Ser 
    850                 855                 860                 


Glu Leu Glu Glu Thr Lys Glu Lys Thr Ser Leu Cys Ser Ser Thr Glu 
865                 870                 875                 880 


Gly Ser Thr Ile Ile Phe Ala Ser Val Gly Asp Lys Glu Ser Asp Thr 
                885                 890                 895     


Ala Ala Lys Gly Pro Pro Gln Pro Gln Pro Cys Phe Thr Asp Gly Cys 
            900                 905                 910         


Val Gln Lys Phe Arg Cys Cys Gln Ile Asn Ile Glu Ser Gly Lys Gly 
        915                 920                 925             


Lys Cys Trp Trp Asn Leu Arg Lys Thr Cys Phe Lys Ile Val Glu His 
    930                 935                 940                 


Asn Trp Phe Glu Thr Phe Ile Val Phe Met Ile Leu Leu Ser Ser Gly 
945                 950                 955                 960 


Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Gln Arg Lys Thr Ile Lys 
                965                 970                 975     


Thr Val Leu Glu Tyr Ala Asp Lys Val Phe Thr Tyr Ile Phe Ile Leu 
            980                 985                 990         


Glu Met Leu Leu Lys Trp Val Ala  Tyr Gly Phe Gln Val  Tyr Phe Thr 
        995                 1000                 1005             


Asn Ala  Trp Cys Trp Leu Asp  Phe Met Ile Val Asp  Val Ser Leu 
    1010                 1015                 1020             


Val Ser  Leu Ile Ala Asn Ala  Leu Asn Tyr Ser Glu  Leu Gly Pro 
    1025                 1030                 1035             


Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu Arg Pro  Leu Arg Ala 
    1040                 1045                 1050             


Leu Ser  Arg Phe Glu Gly Met  Arg Val Val Val Asn  Ala Leu Val 
    1055                 1060                 1065             


Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu Leu Val  Cys Leu Ile 
    1070                 1075                 1080             


Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val Asn Leu  Phe Ala Gly 
    1085                 1090                 1095             


Thr Phe  Phe Glu Cys Val Asn  Lys Thr Asp Gly Val  Arg Ile Ser 
    1100                 1105                 1110             


His Leu  Ile Val Pro Phe Lys  Asn Val Cys Glu Thr  Leu Asp Tyr 
    1115                 1120                 1125             


Ala Arg  Trp Arg Asn Val Lys  Val Asn Phe Asp Asn  Val Gly Ala 
    1130                 1135                 1140             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Met 
    1145                 1150                 1155             


Glu Ile  Met Tyr Ala Ala Val  Asp Ser Thr Gly Ile  Glu Lys Gln 
    1160                 1165                 1170             


Pro Gln  Tyr Glu His Asn Leu  Tyr Met Tyr Leu Tyr  Phe Val Gly 
    1175                 1180                 1185             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1190                 1195                 1200             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1205                 1210                 1215             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1220                 1225                 1230             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1235                 1240                 1245             


Pro Ser  Asn Lys Ile Gln Gly  Phe Ile Phe Asp Phe  Val Thr Lys 
    1250                 1255                 1260             


Gln Ala  Phe Asp Ile Gly Ile  Met Ile Leu Ile Cys  Leu Asn Met 
    1265                 1270                 1275             


Val Thr  Met Met Val Glu Thr  Ala Asp Gln Asp Ser  Ser Val Glu 
    1280                 1285                 1290             


Glu Ile  Leu Tyr Trp Ile Asn  Leu Phe Phe Ile Val  Ile Phe Thr 
    1295                 1300                 1305             


Gly Glu  Cys Leu Leu Lys Leu  Ile Ala Leu Arg Tyr  Tyr Tyr Phe 
    1310                 1315                 1320             


Thr Ile  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Phe Ser 
    1325                 1330                 1335             


Ile Val  Gly Met Cys Leu Ser  Gln Ile Ile Glu Lys  Phe Phe Val 
    1340                 1345                 1350             


Ser Pro  Thr Leu Phe Arg Val  Val Arg Leu Ala Arg  Ile Gly Arg 
    1355                 1360                 1365             


Val Leu  Arg Leu Ile Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1370                 1375                 1380             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1385                 1390                 1395             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1400                 1405                 1410             


Gln Phe  Ala Tyr Val Lys Lys  Glu Ser Gly Ile Asp  Asp Met Phe 
    1415                 1420                 1425             


Asn Phe  Glu Thr Phe Ala Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1430                 1435                 1440             


Thr Thr  Ser Gly Gly Trp Asn  Tyr Leu Leu Phe Pro  Ile Leu Asn 
    1445                 1450                 1455             


Lys Glu  Pro Asp Cys Asp Pro  Lys Lys Val His Pro  Gly Ser Ser 
    1460                 1465                 1470             


Val Glu  Gly Asp Cys Gly Asn  Pro Ser Val Gly Ile  Phe Phe Phe 
    1475                 1480                 1485             


Val Ser  Tyr Ile Ile Ile Ser  Phe Leu Val Val Val  Asn Met Tyr 
    1490                 1495                 1500             


Ile Ala  Val Ile Leu Glu Asn  Phe Ser Val Ala Thr  Glu Glu Ser 
    1505                 1510                 1515             


Ala Glu  Pro Leu Gly Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Val 
    1520                 1525                 1530             


Trp Glu  Lys Phe Asp Pro Gly  Ala Thr Gln Phe Ile  Glu Phe Ser 
    1535                 1540                 1545             


Lys Leu  Phe Asp Phe Ala Ala  Ser Leu Glu Pro Pro  Leu Leu Ile 
    1550                 1555                 1560             


Pro Lys  Pro Asn Lys Val Gln  Leu Ile Ala Met Asp  Leu Pro Ile 
    1565                 1570                 1575             


Val Ser  Gly Asp Arg Ile His  Cys Leu Asp Ile Leu  Phe Ala Phe 
    1580                 1585                 1590             


Thr Lys  Arg Val Leu Gly Glu  Ser Asp Glu Met Asp  Ala Leu Arg 
    1595                 1600                 1605             


Val Gln  Met Glu Asp Arg Phe  Met Ala Ala Asn Pro  Ser Lys Val 
    1610                 1615                 1620             


Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys Arg Lys  Leu Glu Glu 
    1625                 1630                 1635             


Gln Ser  Ala Lys Val Ile Gln  Arg Ala Phe Arg His  Tyr Arg Leu 
    1640                 1645                 1650             


Arg Lys  Pro Val Cys Asn Thr  Ser Tyr Leu Tyr Arg  Asp Gly Asp 
    1655                 1660                 1665             


Val Phe  Pro Ser Lys Thr Glu  Met Ala Phe Asp Lys  Leu Ser Leu 
    1670                 1675                 1680             


Ser Leu  Thr Leu Glu Lys Thr  Glu Arg Ser Ser Ser  Thr Thr Ser 
    1685                 1690                 1695             


Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro Asp Lys  Tyr Glu Gln 
    1700                 1705                 1710             


Glu Lys  Ser Glu Lys Glu Glu  Lys Gly Lys Asp Asp  Lys Asp Tyr 
    1715                 1720                 1725             


Arg Lys  
    1730 


<210>  43
<211>  2005
<212>  PRT
<213>  Pan paniscus

<400>  43

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Phe Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Leu Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Glu Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210>  44
<211>  2005
<212>  PRT
<213>  Macaca mulatta

<400>  44

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Met Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Thr Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Glu Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210>  45
<211>  1932
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Galeopterus variegates

<400>  45

Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro Tyr Tyr Ile 
1               5                   10                  15      


Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala Ile Ser Arg 
            20                  25                  30          


Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu Thr Pro Phe Asn Pro Ile 
        35                  40                  45              


Arg Lys Leu Ala Ile Lys Ile Leu Val His Ser Leu Phe Asn Val Leu 
    50                  55                  60                  


Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe Met Thr Met Ser Asn 
65                  70                  75                  80  


Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr 
                85                  90                  95      


Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Leu Glu 
            100                 105                 110         


Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Thr Val 
        115                 120                 125             


Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp Leu Gly Asn Val Ser 
    130                 135                 140                 


Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val 
145                 150                 155                 160 


Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys 
                165                 170                 175     


Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu Ser Val Phe 
            180                 185                 190         


Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Arg Asn Lys Cys 
        195                 200                 205             


Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe Glu Ile Asn Ile Thr Ser 
    210                 215                 220                 


Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly Thr Thr Phe Asn Arg Thr 
225                 230                 235                 240 


Val Ser Met Phe Asn Trp Asp Glu Tyr Ile Glu Asp Glu Ser His Phe 
                245                 250                 255     


Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser 
            260                 265                 270         


Asp Ala Gly Gln Cys Pro Glu Gly Tyr Val Cys Val Lys Ala Gly Arg 
        275                 280                 285             


Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe 
    290                 295                 300                 


Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp Glu Asn Leu Tyr 
305                 310                 315                 320 


Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val 
                325                 330                 335     


Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala 
            340                 345                 350         


Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Thr Leu Glu Glu 
        355                 360                 365             


Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Leu Glu Gln Leu Lys 
    370                 375                 380                 


Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala Ala Ala Ala Ser Ala Glu 
385                 390                 395                 400 


Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile Gly Val Phe Ser Glu Ser 
                405                 410                 415     


Ser Ser Val Ala Ser Lys Leu Ser Ser Lys Ser Glu Lys Glu Leu Lys 
            420                 425                 430         


Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu Gln Ser Gly Glu Glu Glu 
        435                 440                 445             


Lys Glu Asp Gly Val Arg Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg 
    450                 455                 460                 


Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser Arg Leu Thr Tyr Glu Lys 
465                 470                 475                 480 


Arg Phe Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg Gly Ser Leu 
                485                 490                 495     


Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser Leu Phe Ser Phe Arg Gly 
            500                 505                 510         


Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp Phe Ala Asp Asp Glu His 
        515                 520                 525             


Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg Asp Ser Leu Phe Val Pro 
    530                 535                 540                 


His Arg His Gly Glu Arg Arg His Ser Asn Val Ser Gln Ala Ser Arg 
545                 550                 555                 560 


Ala Ser Arg Leu Leu Pro Thr Leu Pro Met Asn Gly Lys Met His Ser 
                565                 570                 575     


Ala Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly Pro Ser Pro 
            580                 585                 590         


Ala Gly Gln Leu Leu Pro Glu Gly Thr Thr Thr Glu Thr Glu Ile Arg 
        595                 600                 605             


Lys Arg Arg Ser Ser Ser Tyr His Val Ser Met Asp Leu Leu Glu Asp 
    610                 615                 620                 


Pro Thr Ser Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu Thr Asn 
625                 630                 635                 640 


Thr Met Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp 
                645                 650                 655     


Tyr Lys Phe Ala Asn Met Cys Leu Ile Trp Asp Cys Cys Lys Pro Trp 
            660                 665                 670         


Leu Lys Val Lys Arg Leu Val Asn Leu Val Val Met Asp Pro Phe Val 
        675                 680                 685             


Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala 
    690                 695                 700                 


Met Glu His Tyr Pro Met Thr Glu Gln Phe Ser Ser Val Leu Ser Val 
705                 710                 715                 720 


Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe Leu Lys 
                725                 730                 735     


Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile 
            740                 745                 750         


Phe Asp Gly Phe Ile Val Ser Leu Ser Leu Met Glu Leu Gly Leu Ala 
        755                 760                 765             


Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val 
    770                 775                 780                 


Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile 
785                 790                 795                 800 


Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala 
                805                 810                 815     


Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys 
            820                 825                 830         


Ser Tyr Lys Glu Cys Val Cys Lys Ile Ser Asn Asp Cys Glu Leu Pro 
        835                 840                 845             


Arg Trp His Met His Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg 
    850                 855                 860                 


Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val 
865                 870                 875                 880 


Ala Gly Gln Thr Met Cys Leu Thr Val Phe Met Met Val Met Val Ile 
                885                 890                 895     


Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser 
            900                 905                 910         


Phe Ser Ser Asp Asn Leu Ala Ala Thr Asp Asp Asp Asn Glu Met Asn 
        915                 920                 925             


Asn Leu Gln Ile Ala Val Gly Arg Met Gln Lys Gly Ile Asp Phe Val 
    930                 935                 940                 


Lys Arg Lys Ile Arg Glu Phe Ile Gln Lys Ala Phe Val Arg Lys Gln 
945                 950                 955                 960 


Lys Ala Leu Asp Glu Ile Lys Pro Leu Glu Asp Leu Asn Asn Lys Lys 
                965                 970                 975     


Asp Ser Cys Ile Ser Asn His Thr Thr Ile Glu Ile Gly Lys Asp Leu 
            980                 985                 990         


Asn Tyr Leu Lys Asp Gly Asn Gly  Thr Thr Ser Gly Ile  Gly Ser Ser 
        995                 1000                 1005             


Val Glu  Lys Tyr Val Val Asp  Glu Ser Asp Tyr Met  Ser Phe Ile 
    1010                 1015                 1020             


Asn Asn  Pro Ser Leu Thr Val  Thr Val Pro Ile Ala  Leu Gly Glu 
    1025                 1030                 1035             


Ser Asp  Phe Glu Asn Leu Asn  Thr Glu Glu Phe Ser  Ser Glu Ser 
    1040                 1045                 1050             


Asp Met  Glu Glu Ser Lys Glu  Lys Leu Asn Ala Thr  Ser Ser Ser 
    1055                 1060                 1065             


Glu Gly  Ser Thr Val Asp Ile  Gly Ala Pro Ala Glu  Gly Glu Gln 
    1070                 1075                 1080             


Pro Glu  Val Glu Pro Glu Glu  Ser Leu Glu Pro Glu  Ala Cys Phe 
    1085                 1090                 1095             


Thr Glu  Asp Cys Val Arg Lys  Phe Lys Cys Cys Gln  Ile Ser Ile 
    1100                 1105                 1110             


Glu Glu  Gly Lys Gly Lys Leu  Trp Trp Asn Leu Arg  Lys Thr Cys 
    1115                 1120                 1125             


Tyr Lys  Ile Val Glu His Asn  Trp Phe Glu Thr Phe  Ile Val Phe 
    1130                 1135                 1140             


Met Ile  Leu Leu Ser Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr 
    1145                 1150                 1155             


Ile Glu  Gln Arg Lys Thr Ile  Lys Thr Met Leu Glu  Tyr Ala Asp 
    1160                 1165                 1170             


Lys Val  Phe Thr Tyr Ile Phe  Ile Leu Glu Met Leu  Leu Lys Trp 
    1175                 1180                 1185             


Val Ala  Tyr Gly Phe Gln Met  Tyr Phe Thr Asn Ala  Trp Cys Trp 
    1190                 1195                 1200             


Leu Asp  Phe Leu Ile Val Asp  Val Ser Leu Val Ser  Leu Thr Ala 
    1205                 1210                 1215             


Asn Ala  Leu Gly Tyr Ser Glu  Leu Gly Ala Ile Lys  Ser Leu Arg 
    1220                 1225                 1230             


Thr Leu  Arg Ala Leu Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu 
    1235                 1240                 1245             


Gly Met  Arg Val Val Val Asn  Ala Leu Leu Gly Ala  Ile Pro Ser 
    1250                 1255                 1260             


Ile Met  Asn Val Leu Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe 
    1265                 1270                 1275             


Ser Ile  Met Gly Val Asn Leu  Phe Ala Gly Lys Phe  Tyr His Cys 
    1280                 1285                 1290             


Ile Asn  Tyr Thr Thr Gly Glu  Met Phe Asp Val Ser  Val Val Asn 
    1295                 1300                 1305             


Asn Tyr  Ser Glu Cys Lys Ala  Leu Ile Glu Ser Asn  Gln Thr Ala 
    1310                 1315                 1320             


Arg Trp  Lys Asn Val Lys Val  Asn Phe Asp Asn Val  Gly Leu Gly 
    1325                 1330                 1335             


Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp 
    1340                 1345                 1350             


Ile Met  Tyr Ala Ala Val Asp  Ser Arg Asn Val Glu  Leu Gln Pro 
    1355                 1360                 1365             


Lys Tyr  Glu Asp Asn Leu Tyr  Met Tyr Leu Tyr Phe  Val Ile Phe 
    1370                 1375                 1380             


Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val 
    1385                 1390                 1395             


Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys Lys Phe  Gly Gly Gln 
    1400                 1405                 1410             


Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met 
    1415                 1420                 1425             


Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro 
    1430                 1435                 1440             


Ala Asn  Lys Phe Gln Gly Met  Val Phe Asp Phe Val  Thr Lys Gln 
    1445                 1450                 1455             


Val Phe  Asp Ile Ser Ile Met  Ile Leu Ile Cys Leu  Asn Met Val 
    1460                 1465                 1470             


Thr Met  Met Val Glu Thr Asp  Asp Gln Ser Gln Glu  Met Thr Asn 
    1475                 1480                 1485             


Ile Leu  Tyr Trp Ile Asn Leu  Val Phe Ile Val Leu  Phe Thr Gly 
    1490                 1495                 1500             


Glu Cys  Val Leu Lys Leu Ile  Ser Leu Arg Tyr Tyr  Tyr Phe Thr 
    1505                 1510                 1515             


Ile Gly  Trp Asn Ile Phe Asp  Phe Val Val Val Ile  Leu Ser Ile 
    1520                 1525                 1530             


Val Gly  Met Phe Leu Ala Glu  Leu Ile Glu Lys Tyr  Phe Val Ser 
    1535                 1540                 1545             


Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile 
    1550                 1555                 1560             


Leu Arg  Leu Ile Lys Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe 
    1565                 1570                 1575             


Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu 
    1580                 1585                 1590             


Leu Phe  Leu Val Met Phe Ile  Tyr Ala Ile Phe Gly  Met Ser Asn 
    1595                 1600                 1605             


Phe Ala  Tyr Val Lys Arg Glu  Val Gly Ile Asp Asp  Met Phe Asn 
    1610                 1615                 1620             


Phe Glu  Thr Phe Gly Asn Ser  Met Ile Cys Leu Phe  Gln Ile Thr 
    1625                 1630                 1635             


Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Ala Pro Ile  Leu Asn Ser 
    1640                 1645                 1650             


Gly Pro  Pro Asp Cys Asp Pro  Glu Lys Asp His Pro  Gly Ser Ser 
    1655                 1660                 1665             


Val Lys  Gly Asp Cys Gly Asn  Pro Ser Val Gly Ile  Phe Phe Phe 
    1670                 1675                 1680             


Val Ser  Tyr Ile Ile Ile Ser  Phe Leu Val Val Val  Asn Met Tyr 
    1685                 1690                 1695             


Ile Ala  Val Ile Leu Glu Asn  Phe Ser Val Ala Thr  Glu Glu Ser 
    1700                 1705                 1710             


Ala Glu  Pro Leu Ser Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Val 
    1715                 1720                 1725             


Trp Glu  Lys Phe Asp Pro Asp  Ala Thr Gln Phe Ile  Glu Phe Ala 
    1730                 1735                 1740             


Lys Leu  Ser Asp Phe Ala Asp  Ala Leu Asp Pro Pro  Leu Leu Ile 
    1745                 1750                 1755             


Ala Lys  Pro Asn Lys Val Gln  Leu Ile Ala Met Asp  Leu Pro Met 
    1760                 1765                 1770             


Val Ser  Gly Asp Arg Ile His  Cys Leu Asp Ile Leu  Phe Ala Phe 
    1775                 1780                 1785             


Thr Lys  Arg Val Leu Gly Glu  Ser Gly Glu Met Asp  Ala Leu Arg 
    1790                 1795                 1800             


Ile Gln  Met Glu Glu Arg Phe  Met Ala Ser Asn Pro  Ser Lys Val 
    1805                 1810                 1815             


Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys Arg Lys  Gln Glu Glu 
    1820                 1825                 1830             


Val Ser  Ala Ile Ile Ile Gln  Arg Ala Tyr Arg Arg  Tyr Leu Leu 
    1835                 1840                 1845             


Lys Gln  Lys Val Lys Lys Val  Ser Ser Ile Tyr Lys  Lys Asp Lys 
    1850                 1855                 1860             


Gly Lys  Glu Cys Asp Gly Thr  Pro Ile Lys Glu Asp  Thr Leu Ile 
    1865                 1870                 1875             


Asp Lys  Leu Asn Glu Asn Ser  Thr Pro Glu Lys Thr  Asp Met Thr 
    1880                 1885                 1890             


Pro Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1895                 1900                 1905             


Glu Lys  Glu Lys Phe Glu Lys  Asp Lys Ser Glu Lys  Glu Asp Lys 
    1910                 1915                 1920             


Gly Lys  Asp Ile Arg Glu Ser  Lys Lys 
    1925                 1930         


<210>  46
<211>  2006
<212>  PRT
<213>  Bos taurus

<400>  46

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Ser 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Val Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Leu Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Met Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Glu Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Glu Asp Gly Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Ala Gly Gln Leu Leu Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser 
        675                 680                 685             


Tyr His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ala Arg Gln Arg 
    690                 695                 700                 


Ala Met Ser Met Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met 
                725                 730                 735     


Cys Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Val 
            740                 745                 750         


Val Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Leu Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Phe Val Lys Arg  Lys Ile Arg 
    1010                 1015                 1020             


Glu Phe  Ile Gln Lys Ala Phe  Val Arg Lys Gln Lys  Ala Leu Asp 
    1025                 1030                 1035             


Glu Ile  Lys Pro Leu Glu Asp  Leu Asn Asn Lys Lys  Asp Ser Cys 
    1040                 1045                 1050             


Ile Ser  Asn His Thr Thr Ile  Glu Ile Gly Lys Asp  Leu Asn Tyr 
    1055                 1060                 1065             


Leu Lys  Asp Gly Asn Gly Thr  Thr Ser Gly Ile Gly  Ser Ser Val 
    1070                 1075                 1080             


Glu Lys  Tyr Val Val Asp Glu  Ser Asp Tyr Met Ser  Phe Ile Asn 
    1085                 1090                 1095             


Asn Pro  Ser Leu Thr Val Thr  Val Pro Ile Ala Val  Gly Glu Ser 
    1100                 1105                 1110             


Asp Phe  Glu Asn Leu Asn Thr  Glu Glu Phe Ser Ser  Glu Ser Asp 
    1115                 1120                 1125             


Met Glu  Glu Ser Lys Glu Lys  Leu Asn Ala Thr Ser  Ser Ser Glu 
    1130                 1135                 1140             


Gly Ser  Thr Val Asp Ile Gly  Ala Pro Ala Glu Gly  Glu Gln Pro 
    1145                 1150                 1155             


Glu Ala  Glu Pro Glu Glu Ser  Leu Glu Pro Glu Ala  Cys Phe Thr 
    1160                 1165                 1170             


Glu Asp  Cys Val Arg Lys Phe  Lys Cys Cys Gln Ile  Ser Ile Glu 
    1175                 1180                 1185             


Glu Gly  Lys Gly Lys Leu Trp  Trp Asn Leu Arg Lys  Thr Cys Tyr 
    1190                 1195                 1200             


Lys Ile  Val Glu His Asn Trp  Phe Glu Thr Phe Ile  Val Phe Met 
    1205                 1210                 1215             


Ile Leu  Val Ser Ser Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile 
    1220                 1225                 1230             


Glu Gln  Arg Lys Thr Ile Lys  Thr Met Leu Glu Tyr  Ala Asp Lys 
    1235                 1240                 1245             


Val Phe  Thr Tyr Ile Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val 
    1250                 1255                 1260             


Ala Tyr  Gly Phe Gln Val Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu 
    1265                 1270                 1275             


Asp Phe  Leu Ile Val Asp Val  Ser Leu Val Ser Leu  Thr Ala Asn 
    1280                 1285                 1290             


Ala Leu  Gly Tyr Ser Glu Leu  Gly Ala Ile Lys Ser  Leu Arg Thr 
    1295                 1300                 1305             


Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly 
    1310                 1315                 1320             


Met Arg  Val Val Val Asn Ala  Leu Leu Gly Ala Ile  Pro Ser Ile 
    1325                 1330                 1335             


Met Asn  Val Leu Leu Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser 
    1340                 1345                 1350             


Ile Met  Gly Val Asn Leu Phe  Ala Gly Lys Phe Tyr  His Cys Ile 
    1355                 1360                 1365             


Asn Tyr  Thr Thr Gly Glu Met  Phe Asp Val Ser Val  Val Asn Asn 
    1370                 1375                 1380             


Tyr Ser  Glu Cys Lys Ala Leu  Ile Asp Ser Asn Gln  Thr Ala Arg 
    1385                 1390                 1395             


Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn Val Gly  Leu Gly Tyr 
    1400                 1405                 1410             


Leu Ser  Leu Leu Gln Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile 
    1415                 1420                 1425             


Met Tyr  Ala Ala Val Asp Ser  Arg Asn Val Glu Leu  Gln Pro Lys 
    1430                 1435                 1440             


Tyr Glu  Asp Asn Leu Tyr Met  Tyr Leu Tyr Phe Val  Ile Phe Ile 
    1445                 1450                 1455             


Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile 
    1460                 1465                 1470             


Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys Phe Gly  Gly Gln Asp 
    1475                 1480                 1485             


Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys 
    1490                 1495                 1500             


Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Ala 
    1505                 1510                 1515             


Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe Val Thr  Lys Gln Val 
    1520                 1525                 1530             


Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys Leu Asn  Met Val Thr 
    1535                 1540                 1545             


Met Met  Val Glu Thr Asp Asp  Gln Ser Gln Glu Met  Thr Asn Ile 
    1550                 1555                 1560             


Leu Tyr  Trp Ile Asn Leu Val  Phe Ile Val Leu Phe  Thr Gly Glu 
    1565                 1570                 1575             


Cys Val  Leu Lys Leu Ile Ser  Leu Arg Tyr Tyr Tyr  Phe Thr Ile 
    1580                 1585                 1590             


Gly Trp  Asn Ile Phe Asp Phe  Val Val Val Ile Leu  Ser Ile Val 
    1595                 1600                 1605             


Gly Met  Phe Leu Ala Glu Leu  Ile Glu Lys Tyr Phe  Val Ser Pro 
    1610                 1615                 1620             


Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu 
    1625                 1630                 1635             


Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala 
    1640                 1645                 1650             


Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu 
    1655                 1660                 1665             


Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe 
    1670                 1675                 1680             


Ala Tyr  Val Lys Arg Glu Val  Gly Ile Asp Asp Met  Phe Asn Phe 
    1685                 1690                 1695             


Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr 
    1700                 1705                 1710             


Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Gly 
    1715                 1720                 1725             


Pro Pro  Asp Cys Asp Pro Glu  Lys Asp His Pro Gly  Ser Ser Val 
    1730                 1735                 1740             


Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly Ile Phe  Phe Phe Val 
    1745                 1750                 1755             


Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val Val Asn  Met Tyr Ile 
    1760                 1765                 1770             


Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Ala 
    1775                 1780                 1785             


Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp 
    1790                 1795                 1800             


Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe Ile Glu  Phe Ser Lys 
    1805                 1810                 1815             


Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala 
    1820                 1825                 1830             


Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met Asp Leu  Pro Met Val 
    1835                 1840                 1845             


Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr 
    1850                 1855                 1860             


Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ala  Leu Arg Ile 
    1865                 1870                 1875             


Gln Met  Glu Glu Arg Phe Met  Ala Ser Asn Pro Ser  Lys Val Ser 
    1880                 1885                 1890             


Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg Lys Gln  Glu Glu Val 
    1895                 1900                 1905             


Ser Ala  Ile Val Ile Gln Arg  Ala Tyr Arg Arg Tyr  Leu Leu Lys 
    1910                 1915                 1920             


Gln Lys  Val Lys Lys Val Ser  Cys Ile Tyr Lys Lys  Asp Lys Gly 
    1925                 1930                 1935             


Lys Glu  Gly Glu Gly Thr Pro  Ile Lys Glu Asp Ile  Leu Ile Asp 
    1940                 1945                 1950             


Lys Leu  Asn Glu Asn Ser Thr  Pro Glu Lys Thr Asp  Met Thr Pro 
    1955                 1960                 1965             


Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Glu 
    1970                 1975                 1980             


Lys Glu  Lys Phe Glu Lys Asp  Lys Ser Glu Lys Glu  Asp Lys Gly 
    1985                 1990                 1995             


Lys Asp  Ile Arg Glu Ser Lys  Lys 
    2000                 2005     


<210>  47
<211>  2006
<212>  PRT
<213>  Ovis aries

<400>  47

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Ser 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Val Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Leu Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Met Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Glu Asp Gly Val His Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Ala Gly Gln Leu Leu Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser 
        675                 680                 685             


Tyr His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ala Arg Gln Arg 
    690                 695                 700                 


Ala Met Ser Met Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met 
                725                 730                 735     


Cys Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Val 
            740                 745                 750         


Val Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Leu Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Phe Val Lys Arg  Lys Ile Arg 
    1010                 1015                 1020             


Glu Phe  Ile Gln Lys Ala Phe  Val Arg Lys Gln Lys  Ala Leu Asp 
    1025                 1030                 1035             


Glu Ile  Lys Pro Leu Glu Asp  Leu Asn Asn Lys Lys  Asp Ser Cys 
    1040                 1045                 1050             


Ile Ser  Asn His Thr Thr Ile  Glu Ile Gly Lys Asp  Leu Asn Tyr 
    1055                 1060                 1065             


Leu Lys  Asp Gly Asn Gly Thr  Thr Ser Gly Ile Gly  Ser Ser Val 
    1070                 1075                 1080             


Glu Lys  Tyr Val Val Asp Glu  Ser Asp Tyr Met Ser  Phe Ile Asn 
    1085                 1090                 1095             


Asn Pro  Ser Leu Thr Val Thr  Val Pro Ile Ala Val  Gly Glu Ser 
    1100                 1105                 1110             


Asp Phe  Glu Asn Leu Asn Thr  Glu Glu Phe Ser Ser  Glu Ser Asp 
    1115                 1120                 1125             


Met Glu  Glu Ser Lys Glu Lys  Leu Asn Ala Thr Ser  Ser Ser Glu 
    1130                 1135                 1140             


Gly Ser  Thr Val Asp Ile Gly  Ala Pro Ala Glu Gly  Glu Gln Pro 
    1145                 1150                 1155             


Glu Ala  Glu Pro Glu Glu Ser  Leu Glu Pro Glu Ala  Cys Phe Thr 
    1160                 1165                 1170             


Glu Asp  Cys Val Arg Lys Phe  Lys Cys Cys Gln Ile  Ser Ile Glu 
    1175                 1180                 1185             


Glu Gly  Lys Gly Lys Leu Trp  Trp Asn Leu Arg Lys  Thr Cys Tyr 
    1190                 1195                 1200             


Lys Ile  Val Glu His Asn Trp  Phe Glu Thr Phe Ile  Val Phe Met 
    1205                 1210                 1215             


Ile Leu  Val Ser Ser Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile 
    1220                 1225                 1230             


Glu Gln  Arg Lys Thr Ile Lys  Thr Met Leu Glu Tyr  Ala Asp Lys 
    1235                 1240                 1245             


Val Phe  Thr Tyr Ile Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val 
    1250                 1255                 1260             


Ala Tyr  Gly Phe Gln Val Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu 
    1265                 1270                 1275             


Asp Phe  Leu Ile Val Asp Val  Ser Leu Val Ser Leu  Thr Ala Asn 
    1280                 1285                 1290             


Ala Leu  Gly Tyr Ser Glu Leu  Gly Ala Ile Lys Ser  Leu Arg Thr 
    1295                 1300                 1305             


Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly 
    1310                 1315                 1320             


Met Arg  Val Val Val Asn Ala  Leu Leu Gly Ala Ile  Pro Ser Ile 
    1325                 1330                 1335             


Met Asn  Val Leu Leu Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser 
    1340                 1345                 1350             


Ile Met  Gly Val Asn Leu Phe  Ala Gly Lys Phe Tyr  His Cys Ile 
    1355                 1360                 1365             


Asn Tyr  Thr Thr Gly Glu Met  Phe Asp Val Ser Val  Val Asn Asn 
    1370                 1375                 1380             


Tyr Ser  Glu Cys Lys Ala Leu  Ile Asp Ser Asn Gln  Thr Ala Arg 
    1385                 1390                 1395             


Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn Val Gly  Leu Gly Tyr 
    1400                 1405                 1410             


Leu Ser  Leu Leu Gln Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile 
    1415                 1420                 1425             


Met Tyr  Ala Ala Val Asp Ser  Arg Asn Val Glu Leu  Gln Pro Lys 
    1430                 1435                 1440             


Tyr Glu  Asp Asn Leu Tyr Met  Tyr Leu Tyr Phe Val  Ile Phe Ile 
    1445                 1450                 1455             


Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile 
    1460                 1465                 1470             


Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys Phe Gly  Gly Gln Asp 
    1475                 1480                 1485             


Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys 
    1490                 1495                 1500             


Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Ala 
    1505                 1510                 1515             


Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe Val Thr  Lys Gln Val 
    1520                 1525                 1530             


Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys Leu Asn  Met Val Thr 
    1535                 1540                 1545             


Met Met  Val Glu Thr Asp Asp  Gln Ser Gln Glu Met  Thr Asn Ile 
    1550                 1555                 1560             


Leu Tyr  Trp Ile Asn Leu Val  Phe Ile Val Leu Phe  Thr Gly Glu 
    1565                 1570                 1575             


Cys Val  Leu Lys Leu Ile Ser  Leu Arg Tyr Tyr Tyr  Phe Thr Ile 
    1580                 1585                 1590             


Gly Trp  Asn Ile Phe Asp Phe  Val Val Val Ile Leu  Ser Ile Val 
    1595                 1600                 1605             


Gly Met  Phe Leu Ala Glu Leu  Ile Glu Lys Tyr Phe  Val Ser Pro 
    1610                 1615                 1620             


Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu 
    1625                 1630                 1635             


Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala 
    1640                 1645                 1650             


Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu 
    1655                 1660                 1665             


Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe 
    1670                 1675                 1680             


Ala Tyr  Val Lys Arg Glu Val  Gly Ile Asp Asp Met  Phe Asn Phe 
    1685                 1690                 1695             


Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr 
    1700                 1705                 1710             


Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Gly 
    1715                 1720                 1725             


Pro Pro  Asp Cys Asp Pro Glu  Lys Asp His Pro Gly  Ser Ser Val 
    1730                 1735                 1740             


Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly Ile Phe  Phe Phe Val 
    1745                 1750                 1755             


Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val Val Asn  Met Tyr Ile 
    1760                 1765                 1770             


Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Ala 
    1775                 1780                 1785             


Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp 
    1790                 1795                 1800             


Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe Ile Glu  Phe Ser Lys 
    1805                 1810                 1815             


Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala 
    1820                 1825                 1830             


Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met Asp Leu  Pro Met Val 
    1835                 1840                 1845             


Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr 
    1850                 1855                 1860             


Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ala  Leu Arg Ile 
    1865                 1870                 1875             


Gln Met  Glu Glu Arg Phe Met  Ala Ser Asn Pro Ser  Lys Val Ser 
    1880                 1885                 1890             


Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg Lys Gln  Glu Glu Val 
    1895                 1900                 1905             


Ser Ala  Ile Val Ile Gln Arg  Ala Tyr Arg Arg Tyr  Leu Leu Lys 
    1910                 1915                 1920             


Gln Lys  Val Lys Lys Val Ser  Cys Ile Tyr Lys Lys  Asp Lys Gly 
    1925                 1930                 1935             


Lys Glu  Gly Glu Gly Thr Pro  Ile Lys Glu Asp Ile  Leu Ile Asp 
    1940                 1945                 1950             


Lys Leu  Asn Glu Asn Ser Thr  Pro Glu Lys Thr Asp  Met Thr Pro 
    1955                 1960                 1965             


Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Glu 
    1970                 1975                 1980             


Lys Glu  Lys Phe Glu Lys Asp  Lys Ser Glu Lys Glu  Asp Lys Gly 
    1985                 1990                 1995             


Lys Asp  Ile Arg Glu Ser Lys  Lys 
    2000                 2005     


<210>  48
<211>  2006
<212>  PRT
<213>  Camelus dromedarius

<400>  48

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Val Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Leu 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Met Phe Asn Trp Asp Asp Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Glu Asp Gly Val His Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Ala Gly Gln Leu Leu Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser 
        675                 680                 685             


Tyr His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ala Arg Gln Arg 
    690                 695                 700                 


Ala Met Ser Met Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Thr 
                725                 730                 735     


Cys Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu 
            740                 745                 750         


Val Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Leu Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Tyr Val Lys Arg  Lys Ile Arg 
    1010                 1015                 1020             


Glu Phe  Ile Gln Lys Ala Phe  Val Arg Lys Gln Lys  Ala Leu Asp 
    1025                 1030                 1035             


Glu Ile  Lys Pro Leu Glu Asp  Leu Asn Asn Lys Lys  Asp Ser Cys 
    1040                 1045                 1050             


Ile Ser  Asn His Thr Thr Ile  Glu Ile Gly Lys Asp  Leu Asn Tyr 
    1055                 1060                 1065             


Leu Lys  Asp Gly Asn Gly Thr  Thr Ser Gly Ile Gly  Ser Ser Val 
    1070                 1075                 1080             


Glu Lys  Tyr Val Val Asp Glu  Ser Asp Tyr Met Ser  Phe Ile Asn 
    1085                 1090                 1095             


Asn Pro  Ser Leu Thr Val Thr  Val Pro Ile Ala Val  Gly Glu Ser 
    1100                 1105                 1110             


Asp Phe  Glu Asn Leu Asn Thr  Glu Glu Phe Ser Ser  Glu Ser Asp 
    1115                 1120                 1125             


Met Glu  Glu Ser Lys Glu Lys  Leu Asn Ala Thr Ser  Ser Ser Glu 
    1130                 1135                 1140             


Gly Ser  Thr Val Asp Ile Gly  Ala Pro Ala Glu Gly  Glu Gln Pro 
    1145                 1150                 1155             


Glu Val  Glu Pro Glu Glu Ser  Leu Glu Pro Glu Ala  Cys Phe Thr 
    1160                 1165                 1170             


Glu Asp  Cys Val Arg Lys Phe  Lys Cys Cys Gln Ile  Ser Ile Glu 
    1175                 1180                 1185             


Glu Gly  Lys Gly Lys Leu Trp  Trp Asn Val Arg Lys  Thr Cys Tyr 
    1190                 1195                 1200             


Lys Ile  Val Glu His Asn Trp  Phe Glu Thr Phe Ile  Val Phe Met 
    1205                 1210                 1215             


Ile Leu  Leu Ser Ser Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile 
    1220                 1225                 1230             


Glu Gln  Arg Lys Thr Ile Lys  Thr Met Leu Glu Tyr  Ala Asp Lys 
    1235                 1240                 1245             


Val Phe  Thr Tyr Ile Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val 
    1250                 1255                 1260             


Ala Tyr  Gly Phe Gln Val Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu 
    1265                 1270                 1275             


Asp Phe  Leu Ile Val Asp Val  Ser Leu Val Ser Leu  Thr Ala Asn 
    1280                 1285                 1290             


Ala Leu  Gly Tyr Ser Glu Leu  Gly Ala Ile Lys Ser  Leu Arg Thr 
    1295                 1300                 1305             


Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly 
    1310                 1315                 1320             


Met Arg  Val Val Val Asn Ala  Leu Leu Gly Ala Ile  Pro Ser Ile 
    1325                 1330                 1335             


Met Asn  Val Leu Leu Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser 
    1340                 1345                 1350             


Ile Met  Gly Val Asn Leu Phe  Ala Gly Lys Phe Tyr  His Cys Ile 
    1355                 1360                 1365             


Asn Tyr  Thr Thr Gly Glu Met  Phe Asp Val Ser Val  Val Asn Asn 
    1370                 1375                 1380             


Tyr Ser  Glu Cys Lys Ala Leu  Ile Glu Ser Asn Gln  Thr Ala Arg 
    1385                 1390                 1395             


Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn Val Gly  Leu Gly Tyr 
    1400                 1405                 1410             


Leu Ser  Leu Leu Gln Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile 
    1415                 1420                 1425             


Met Tyr  Ala Ala Val Asp Ser  Arg Asn Val Glu Leu  Gln Pro Lys 
    1430                 1435                 1440             


Tyr Glu  Asp Asn Leu Tyr Met  Tyr Leu Tyr Phe Val  Ile Phe Ile 
    1445                 1450                 1455             


Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile 
    1460                 1465                 1470             


Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys Phe Gly  Gly Gln Asp 
    1475                 1480                 1485             


Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys 
    1490                 1495                 1500             


Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Ala 
    1505                 1510                 1515             


Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe Val Thr  Lys Gln Val 
    1520                 1525                 1530             


Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys Leu Asn  Met Val Thr 
    1535                 1540                 1545             


Met Met  Val Glu Thr Asp Asp  Gln Ser Gln Glu Met  Thr Asn Ile 
    1550                 1555                 1560             


Leu Tyr  Trp Ile Asn Leu Val  Phe Ile Val Leu Phe  Thr Gly Glu 
    1565                 1570                 1575             


Cys Val  Leu Lys Leu Ile Ser  Leu Arg Tyr Tyr Tyr  Phe Thr Ile 
    1580                 1585                 1590             


Gly Trp  Asn Ile Phe Asp Phe  Val Val Val Ile Leu  Ser Ile Val 
    1595                 1600                 1605             


Gly Met  Phe Leu Ala Glu Leu  Ile Glu Lys Tyr Phe  Val Ser Pro 
    1610                 1615                 1620             


Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu 
    1625                 1630                 1635             


Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala 
    1640                 1645                 1650             


Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu 
    1655                 1660                 1665             


Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe 
    1670                 1675                 1680             


Ala Tyr  Val Lys Arg Glu Val  Gly Ile Asp Asp Met  Phe Asn Phe 
    1685                 1690                 1695             


Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr 
    1700                 1705                 1710             


Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Gly 
    1715                 1720                 1725             


Pro Pro  Asp Cys Asp Pro Glu  Lys Asp His Pro Gly  Ser Ser Val 
    1730                 1735                 1740             


Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly Ile Phe  Phe Phe Val 
    1745                 1750                 1755             


Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val Val Asn  Met Tyr Ile 
    1760                 1765                 1770             


Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Ala 
    1775                 1780                 1785             


Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp 
    1790                 1795                 1800             


Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe Ile Glu  Phe Ser Lys 
    1805                 1810                 1815             


Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala 
    1820                 1825                 1830             


Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met Asp Leu  Pro Met Val 
    1835                 1840                 1845             


Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr 
    1850                 1855                 1860             


Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ala  Leu Arg Ile 
    1865                 1870                 1875             


Gln Met  Glu Glu Arg Phe Met  Ala Ser Asn Pro Ser  Lys Val Ser 
    1880                 1885                 1890             


Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg Lys Gln  Glu Glu Val 
    1895                 1900                 1905             


Ser Ala  Ile Val Ile Gln Arg  Ala Tyr Arg Arg Tyr  Leu Leu Lys 
    1910                 1915                 1920             


Gln Lys  Val Lys Lys Val Ser  Cys Ile Tyr Lys Lys  Asp Lys Gly 
    1925                 1930                 1935             


Lys Glu  Gly Asp Gly Thr Pro  Ile Lys Glu Asp Thr  Leu Ile Asp 
    1940                 1945                 1950             


Lys Leu  Asn Glu Asn Ser Thr  Pro Glu Lys Thr Asp  Gly Thr Pro 
    1955                 1960                 1965             


Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Glu 
    1970                 1975                 1980             


Lys Glu  Lys Phe Glu Lys Asp  Lys Ser Glu Lys Glu  Asp Lys Gly 
    1985                 1990                 1995             


Lys Asp  Ile Arg Glu Ser Lys  Lys 
    2000                 2005     


<210>  49
<211>  2006
<212>  PRT
<213>  Orcinus orca

<400>  49

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Val Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Met Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Glu Asp Gly Val His Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Pro Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Val Leu Pro Val 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Ala Gly Gln Leu Leu Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser 
        675                 680                 685             


Tyr His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ala Lys Gln Arg 
    690                 695                 700                 


Ala Thr Ser Met Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met 
                725                 730                 735     


Cys Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu 
            740                 745                 750         


Val Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Leu Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Tyr Val Lys Arg  Lys Ile Arg 
    1010                 1015                 1020             


Glu Phe  Ile Gln Lys Ala Phe  Val Arg Lys Gln Lys  Ala Leu Asp 
    1025                 1030                 1035             


Glu Ile  Lys Pro Leu Glu Asp  Leu Asn Asn Lys Lys  Asp Ser Cys 
    1040                 1045                 1050             


Ile Ser  Asn His Thr Thr Ile  Glu Ile Gly Lys Asp  Leu Asn Tyr 
    1055                 1060                 1065             


Leu Lys  Asp Gly Asn Gly Thr  Thr Ser Gly Ile Gly  Ser Ser Val 
    1070                 1075                 1080             


Glu Lys  Tyr Val Val Asp Glu  Ser Asp Tyr Met Ser  Phe Ile Asn 
    1085                 1090                 1095             


Asn Pro  Ser Leu Thr Val Thr  Val Pro Ile Ala Val  Gly Glu Ser 
    1100                 1105                 1110             


Asp Phe  Glu Asn Leu Asn Thr  Glu Glu Phe Ser Ser  Glu Ser Asp 
    1115                 1120                 1125             


Met Glu  Glu Ser Lys Glu Lys  Leu Asn Ala Thr Ser  Ser Ser Glu 
    1130                 1135                 1140             


Gly Ser  Thr Val Asp Ile Gly  Ala Pro Ala Glu Gly  Glu Gln Pro 
    1145                 1150                 1155             


Glu Val  Glu Pro Glu Glu Ser  Leu Glu Pro Glu Ala  Cys Phe Thr 
    1160                 1165                 1170             


Glu Asp  Cys Val Arg Lys Phe  Lys Cys Cys Gln Ile  Ser Ile Glu 
    1175                 1180                 1185             


Glu Gly  Lys Gly Lys Leu Trp  Trp Asn Leu Arg Lys  Thr Cys Tyr 
    1190                 1195                 1200             


Lys Ile  Val Glu His Asn Trp  Phe Glu Thr Phe Ile  Val Phe Met 
    1205                 1210                 1215             


Ile Leu  Leu Ser Ser Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile 
    1220                 1225                 1230             


Glu Gln  Arg Lys Thr Ile Lys  Thr Met Leu Glu Tyr  Ala Asp Lys 
    1235                 1240                 1245             


Val Phe  Thr Tyr Ile Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val 
    1250                 1255                 1260             


Ala Tyr  Gly Phe Gln Val Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu 
    1265                 1270                 1275             


Asp Phe  Leu Ile Val Asp Val  Ser Leu Val Ser Leu  Thr Ala Asn 
    1280                 1285                 1290             


Ala Leu  Gly Tyr Ser Glu Leu  Gly Ala Ile Lys Ser  Leu Arg Thr 
    1295                 1300                 1305             


Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly 
    1310                 1315                 1320             


Met Arg  Val Val Val Asn Ala  Leu Leu Gly Ala Ile  Pro Ser Ile 
    1325                 1330                 1335             


Met Asn  Val Leu Leu Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser 
    1340                 1345                 1350             


Ile Met  Gly Val Asn Leu Phe  Ala Gly Lys Phe Tyr  His Cys Ile 
    1355                 1360                 1365             


Asn Tyr  Thr Thr Gly Glu Met  Phe Asp Val Ser Val  Val Asn Asn 
    1370                 1375                 1380             


Tyr Ser  Glu Cys Lys Ala Leu  Ile Glu Ser Asn Gln  Thr Ala Arg 
    1385                 1390                 1395             


Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn Val Gly  Leu Gly Tyr 
    1400                 1405                 1410             


Leu Ser  Leu Leu Gln Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile 
    1415                 1420                 1425             


Met Tyr  Ala Ala Val Asp Ser  Arg Asn Val Glu Leu  Gln Pro Lys 
    1430                 1435                 1440             


Tyr Glu  Asp Asn Leu Tyr Met  Tyr Leu Tyr Phe Val  Ile Phe Ile 
    1445                 1450                 1455             


Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile 
    1460                 1465                 1470             


Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys Phe Gly  Gly Gln Asp 
    1475                 1480                 1485             


Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys 
    1490                 1495                 1500             


Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Ala 
    1505                 1510                 1515             


Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe Val Thr  Lys Gln Val 
    1520                 1525                 1530             


Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys Leu Asn  Met Val Thr 
    1535                 1540                 1545             


Met Met  Val Glu Thr Asp Asp  Gln Ser Gln Glu Met  Thr Asn Ile 
    1550                 1555                 1560             


Leu Tyr  Trp Ile Asn Leu Val  Phe Ile Val Leu Phe  Thr Gly Glu 
    1565                 1570                 1575             


Cys Val  Leu Lys Leu Ile Ser  Leu Arg Tyr Tyr Tyr  Phe Thr Ile 
    1580                 1585                 1590             


Gly Trp  Asn Ile Phe Asp Phe  Val Val Val Ile Leu  Ser Ile Val 
    1595                 1600                 1605             


Gly Met  Phe Leu Ala Glu Leu  Ile Glu Lys Tyr Phe  Val Ser Pro 
    1610                 1615                 1620             


Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu 
    1625                 1630                 1635             


Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala 
    1640                 1645                 1650             


Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu 
    1655                 1660                 1665             


Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe 
    1670                 1675                 1680             


Ala Tyr  Val Lys Arg Glu Val  Gly Ile Asp Asp Met  Phe Asn Phe 
    1685                 1690                 1695             


Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr 
    1700                 1705                 1710             


Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Gly 
    1715                 1720                 1725             


Pro Pro  Asp Cys Asp Pro Glu  Lys Asp His Pro Gly  Ser Ser Val 
    1730                 1735                 1740             


Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly Ile Phe  Phe Phe Val 
    1745                 1750                 1755             


Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val Val Asn  Met Tyr Ile 
    1760                 1765                 1770             


Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Ala 
    1775                 1780                 1785             


Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp 
    1790                 1795                 1800             


Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe Ile Glu  Phe Ser Lys 
    1805                 1810                 1815             


Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala 
    1820                 1825                 1830             


Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met Asp Leu  Pro Met Val 
    1835                 1840                 1845             


Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr 
    1850                 1855                 1860             


Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ala  Leu Arg Ile 
    1865                 1870                 1875             


Gln Met  Glu Glu Arg Phe Met  Ala Ser Asn Pro Ser  Lys Val Ser 
    1880                 1885                 1890             


Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg Lys Gln  Glu Glu Val 
    1895                 1900                 1905             


Ser Ala  Ile Val Ile Gln Arg  Ala Tyr Arg Arg Tyr  Leu Leu Lys 
    1910                 1915                 1920             


Gln Lys  Val Lys Lys Val Ser  Cys Ile Tyr Lys Lys  Asp Lys Gly 
    1925                 1930                 1935             


Lys Glu  Ala Asp Gly Thr Pro  Ile Lys Glu Asp Ile  Leu Thr Asp 
    1940                 1945                 1950             


Lys Leu  Asn Glu Asn Ser Thr  Pro Glu Lys Thr Asp  Val Thr Pro 
    1955                 1960                 1965             


Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Glu 
    1970                 1975                 1980             


Lys Glu  Lys Phe Glu Lys Asp  Lys Ser Glu Lys Glu  Asp Lys Gly 
    1985                 1990                 1995             


Lys Asp  Ile Arg Glu Ser Lys  Lys 
    2000                 2005     


<210>  50
<211>  2006
<212>  PRT
<213>  Equus caballus

<400>  50

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Val Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Ile Phe Asn Arg Thr Val Ser Met Phe Asn Trp Asp Asp Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Val 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Glu Asp Gly Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Ala Gly Gln Leu Leu Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser 
        675                 680                 685             


Tyr His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ala Arg Gln Arg 
    690                 695                 700                 


Ala Met Ser Met Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met 
                725                 730                 735     


Cys Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu 
            740                 745                 750         


Val Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Tyr Val Lys Arg  Lys Leu Arg 
    1010                 1015                 1020             


Glu Phe  Ile Gln Lys Ala Phe  Val Arg Lys Gln Lys  Ala Leu Asp 
    1025                 1030                 1035             


Glu Ile  Lys Pro Leu Glu Asp  Leu Asn Asn Lys Lys  Asp Ser Cys 
    1040                 1045                 1050             


Ile Ser  Asn His Thr Thr Ile  Glu Ile Gly Lys Asp  Leu Asn Tyr 
    1055                 1060                 1065             


Leu Lys  Asp Gly Asn Gly Thr  Thr Ser Gly Ile Gly  Ser Ser Val 
    1070                 1075                 1080             


Glu Lys  Tyr Val Val Asp Glu  Ser Asp Tyr Met Ser  Phe Ile Asn 
    1085                 1090                 1095             


Asn Pro  Ser Leu Thr Val Thr  Val Pro Ile Ala Val  Gly Glu Ser 
    1100                 1105                 1110             


Asp Phe  Glu Asn Leu Asn Thr  Glu Glu Phe Ser Ser  Glu Ser Asp 
    1115                 1120                 1125             


Met Glu  Glu Ser Lys Glu Lys  Leu Asn Ala Thr Ser  Ser Ser Glu 
    1130                 1135                 1140             


Gly Ser  Thr Val Asp Ile Gly  Ala Pro Ala Glu Gly  Glu Gln Pro 
    1145                 1150                 1155             


Glu Ala  Glu Pro Glu Glu Ser  Leu Glu Pro Glu Ala  Cys Phe Thr 
    1160                 1165                 1170             


Glu Asp  Cys Val Arg Lys Phe  Lys Cys Cys Gln Ile  Ser Ile Glu 
    1175                 1180                 1185             


Glu Gly  Lys Gly Lys Leu Trp  Trp Asn Val Arg Lys  Thr Cys Tyr 
    1190                 1195                 1200             


Lys Ile  Val Glu His Asn Trp  Phe Glu Thr Phe Ile  Val Phe Met 
    1205                 1210                 1215             


Ile Leu  Leu Ser Ser Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile 
    1220                 1225                 1230             


Glu Gln  Arg Lys Thr Ile Lys  Thr Met Leu Glu Tyr  Ala Asp Lys 
    1235                 1240                 1245             


Val Phe  Thr Tyr Ile Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val 
    1250                 1255                 1260             


Ala Tyr  Gly Phe Gln Val Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu 
    1265                 1270                 1275             


Asp Phe  Leu Ile Val Asp Val  Ser Leu Val Ser Leu  Thr Ala Asn 
    1280                 1285                 1290             


Ala Leu  Gly Tyr Ser Glu Leu  Gly Ala Ile Lys Ser  Leu Arg Thr 
    1295                 1300                 1305             


Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly 
    1310                 1315                 1320             


Met Arg  Val Val Val Asn Ala  Leu Leu Gly Ala Ile  Pro Ser Ile 
    1325                 1330                 1335             


Met Asn  Val Leu Leu Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser 
    1340                 1345                 1350             


Ile Met  Gly Val Asn Leu Phe  Ala Gly Lys Phe Tyr  His Cys Ile 
    1355                 1360                 1365             


Asn Tyr  Thr Thr Gly Glu Met  Phe Asp Val Ser Val  Val Asn Asn 
    1370                 1375                 1380             


Tyr Ser  Glu Cys Lys Ala Leu  Ile Glu Ser Asn Gln  Thr Ala Arg 
    1385                 1390                 1395             


Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn Val Gly  Leu Gly Tyr 
    1400                 1405                 1410             


Leu Ser  Leu Leu Gln Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile 
    1415                 1420                 1425             


Met Tyr  Ala Ala Val Asp Ser  Arg Asn Val Glu Leu  Gln Pro Lys 
    1430                 1435                 1440             


Tyr Glu  Asp Asn Leu Tyr Met  Tyr Leu Tyr Phe Val  Ile Phe Ile 
    1445                 1450                 1455             


Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile 
    1460                 1465                 1470             


Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys Phe Gly  Gly Gln Asp 
    1475                 1480                 1485             


Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys 
    1490                 1495                 1500             


Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Ala 
    1505                 1510                 1515             


Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe Val Thr  Lys Gln Val 
    1520                 1525                 1530             


Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys Leu Asn  Met Val Thr 
    1535                 1540                 1545             


Met Met  Val Glu Thr Asp Asp  Gln Ser Gln Glu Met  Thr Asn Ile 
    1550                 1555                 1560             


Leu Tyr  Trp Ile Asn Leu Val  Phe Ile Val Leu Phe  Thr Gly Glu 
    1565                 1570                 1575             


Cys Val  Leu Lys Leu Ile Ser  Leu Arg Tyr Tyr Tyr  Phe Thr Ile 
    1580                 1585                 1590             


Gly Trp  Asn Ile Phe Asp Phe  Val Val Val Ile Leu  Ser Ile Val 
    1595                 1600                 1605             


Gly Met  Phe Leu Ala Glu Leu  Ile Glu Lys Tyr Phe  Val Ser Pro 
    1610                 1615                 1620             


Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu 
    1625                 1630                 1635             


Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala 
    1640                 1645                 1650             


Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu 
    1655                 1660                 1665             


Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe 
    1670                 1675                 1680             


Ala Tyr  Val Lys Arg Glu Val  Gly Ile Asp Asp Met  Phe Asn Phe 
    1685                 1690                 1695             


Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr 
    1700                 1705                 1710             


Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Gly 
    1715                 1720                 1725             


Pro Pro  Asp Cys Asp Pro Glu  Lys Asp His Pro Gly  Ser Ser Val 
    1730                 1735                 1740             


Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly Ile Phe  Phe Phe Val 
    1745                 1750                 1755             


Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val Val Asn  Met Tyr Ile 
    1760                 1765                 1770             


Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Ala 
    1775                 1780                 1785             


Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp 
    1790                 1795                 1800             


Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe Ile Glu  Phe Ser Lys 
    1805                 1810                 1815             


Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala 
    1820                 1825                 1830             


Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met Asp Leu  Pro Met Val 
    1835                 1840                 1845             


Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr 
    1850                 1855                 1860             


Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ala  Leu Arg Ile 
    1865                 1870                 1875             


Gln Met  Glu Glu Arg Phe Met  Ala Ser Asn Pro Ser  Lys Val Ser 
    1880                 1885                 1890             


Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg Lys Gln  Glu Glu Val 
    1895                 1900                 1905             


Ser Ala  Ile Val Ile Gln Arg  Ala Tyr Arg Arg Tyr  Leu Leu Lys 
    1910                 1915                 1920             


Gln Lys  Val Lys Lys Val Ser  Cys Ile Tyr Lys Lys  Asp Lys Val 
    1925                 1930                 1935             


Lys Glu  Gly Asp Gly Thr Pro  Ile Lys Glu Asp Ile  Leu Ile Asp 
    1940                 1945                 1950             


Lys Leu  Asn Glu Asn Ser Thr  Pro Glu Lys Thr Asp  Val Thr Pro 
    1955                 1960                 1965             


Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Glu 
    1970                 1975                 1980             


Lys Glu  Lys Phe Glu Lys Asp  Lys Ser Glu Lys Glu  Asp Lys Gly 
    1985                 1990                 1995             


Lys Asp  Ile Arg Glu Ser Lys  Lys 
    2000                 2005     


<210>  51
<211>  2006
<212>  PRT
<213>  Mus musculus

<400>  51

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Val Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Thr Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Trp Asn Gly 
    290                 295                 300                 


Thr Ala Phe Asn Arg Thr Met Asn Met Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ala Gly Glu Glu Glu Lys Glu Asp Ala Val Arg Lys Ser Ala Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Lys Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Lys Gly Arg Val Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Pro Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Gly Ile Pro Thr Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Val Gly Gln Leu Leu Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser 
        675                 680                 685             


Tyr His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg 
    690                 695                 700                 


Ala Met Ser Met Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met 
                725                 730                 735     


Cys Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Val 
            740                 745                 750         


Val Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Phe Val Lys Arg  Lys Ile Arg 
    1010                 1015                 1020             


Glu Phe  Ile Gln Lys Ala Phe  Val Arg Lys Gln Lys  Ala Leu Asp 
    1025                 1030                 1035             


Glu Ile  Lys Pro Leu Glu Asp  Leu Asn Asn Lys Lys  Asp Ser Cys 
    1040                 1045                 1050             


Ile Ser  Asn His Thr Thr Ile  Glu Ile Gly Lys Asp  Leu Asn Tyr 
    1055                 1060                 1065             


Leu Lys  Asp Gly Asn Gly Thr  Thr Ser Gly Ile Gly  Ser Ser Val 
    1070                 1075                 1080             


Glu Lys  Tyr Val Val Asp Glu  Ser Asp Tyr Met Ser  Phe Ile Asn 
    1085                 1090                 1095             


Asn Pro  Ser Leu Thr Val Thr  Val Pro Ile Ala Val  Gly Glu Ser 
    1100                 1105                 1110             


Asp Phe  Glu Asn Leu Asn Thr  Glu Glu Phe Ser Ser  Glu Ser Asp 
    1115                 1120                 1125             


Met Glu  Glu Ser Lys Glu Lys  Leu Asn Ala Thr Ser  Ser Ser Glu 
    1130                 1135                 1140             


Gly Ser  Thr Val Asp Ile Gly  Ala Pro Ala Glu Gly  Glu Gln Pro 
    1145                 1150                 1155             


Glu Ala  Glu Pro Glu Glu Ser  Leu Glu Pro Glu Ala  Cys Phe Thr 
    1160                 1165                 1170             


Glu Asp  Cys Val Arg Lys Phe  Lys Cys Cys Gln Ile  Ser Ile Glu 
    1175                 1180                 1185             


Glu Gly  Lys Gly Lys Leu Trp  Trp Asn Leu Arg Lys  Thr Cys Tyr 
    1190                 1195                 1200             


Lys Ile  Val Glu His Asn Trp  Phe Glu Thr Phe Ile  Val Phe Met 
    1205                 1210                 1215             


Ile Leu  Leu Ser Ser Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile 
    1220                 1225                 1230             


Glu Gln  Arg Lys Thr Ile Lys  Thr Met Leu Glu Tyr  Ala Asp Lys 
    1235                 1240                 1245             


Val Phe  Thr Tyr Ile Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val 
    1250                 1255                 1260             


Ala Tyr  Gly Phe Gln Met Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu 
    1265                 1270                 1275             


Asp Phe  Leu Ile Val Asp Val  Ser Leu Val Ser Leu  Thr Ala Asn 
    1280                 1285                 1290             


Ala Leu  Gly Tyr Ser Glu Leu  Gly Ala Ile Lys Ser  Leu Arg Thr 
    1295                 1300                 1305             


Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly 
    1310                 1315                 1320             


Met Arg  Val Val Val Asn Ala  Leu Leu Gly Ala Ile  Pro Ser Ile 
    1325                 1330                 1335             


Met Asn  Val Leu Leu Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser 
    1340                 1345                 1350             


Ile Met  Gly Val Asn Leu Phe  Ala Gly Lys Phe Tyr  His Cys Ile 
    1355                 1360                 1365             


Asn Tyr  Thr Thr Gly Glu Met  Phe Asp Val Ser Val  Val Asn Asn 
    1370                 1375                 1380             


Tyr Ser  Glu Cys Gln Ala Leu  Ile Glu Ser Asn Gln  Thr Ala Arg 
    1385                 1390                 1395             


Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn Val Gly  Leu Gly Tyr 
    1400                 1405                 1410             


Leu Ser  Leu Leu Gln Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile 
    1415                 1420                 1425             


Met Tyr  Ala Ala Val Asp Ser  Arg Asn Val Glu Leu  Gln Pro Lys 
    1430                 1435                 1440             


Tyr Glu  Asp Asn Leu Tyr Met  Tyr Leu Tyr Phe Val  Ile Phe Ile 
    1445                 1450                 1455             


Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile 
    1460                 1465                 1470             


Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys Phe Gly  Gly Gln Asp 
    1475                 1480                 1485             


Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys 
    1490                 1495                 1500             


Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Ala 
    1505                 1510                 1515             


Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe Val Thr  Lys Gln Val 
    1520                 1525                 1530             


Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys Leu Asn  Met Val Thr 
    1535                 1540                 1545             


Met Met  Val Glu Thr Asp Asp  Gln Ser Gln Glu Met  Thr Asn Ile 
    1550                 1555                 1560             


Leu Tyr  Trp Ile Asn Leu Val  Phe Ile Val Leu Phe  Thr Gly Glu 
    1565                 1570                 1575             


Cys Val  Leu Lys Leu Ile Ser  Leu Arg His Tyr Tyr  Phe Thr Ile 
    1580                 1585                 1590             


Gly Trp  Asn Ile Phe Asp Phe  Val Val Val Ile Leu  Ser Ile Val 
    1595                 1600                 1605             


Gly Met  Phe Leu Ala Glu Leu  Ile Glu Lys Tyr Phe  Val Ser Pro 
    1610                 1615                 1620             


Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu 
    1625                 1630                 1635             


Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala 
    1640                 1645                 1650             


Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu 
    1655                 1660                 1665             


Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe 
    1670                 1675                 1680             


Ala Tyr  Val Lys Arg Glu Val  Gly Ile Asp Asp Met  Phe Asn Phe 
    1685                 1690                 1695             


Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr 
    1700                 1705                 1710             


Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Gly 
    1715                 1720                 1725             


Pro Pro  Asp Cys Asp Pro Glu  Lys Asp His Pro Gly  Ser Ser Val 
    1730                 1735                 1740             


Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly Ile Phe  Phe Phe Val 
    1745                 1750                 1755             


Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val Val Asn  Met Tyr Ile 
    1760                 1765                 1770             


Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Ala 
    1775                 1780                 1785             


Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp 
    1790                 1795                 1800             


Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe Ile Glu  Phe Cys Lys 
    1805                 1810                 1815             


Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala 
    1820                 1825                 1830             


Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met Asp Leu  Pro Met Val 
    1835                 1840                 1845             


Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr 
    1850                 1855                 1860             


Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ala  Leu Arg Ile 
    1865                 1870                 1875             


Gln Met  Glu Glu Arg Phe Met  Ala Ser Asn Pro Ser  Lys Val Ser 
    1880                 1885                 1890             


Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg Lys Gln  Glu Glu Val 
    1895                 1900                 1905             


Ser Ala  Ile Val Ile Gln Arg  Ala Tyr Arg Arg Tyr  Leu Leu Lys 
    1910                 1915                 1920             


Gln Lys  Val Lys Lys Val Ser  Ser Ile Tyr Lys Lys  Asp Lys Gly 
    1925                 1930                 1935             


Lys Glu  Asp Glu Gly Thr Pro  Ile Lys Glu Asp Ile  Ile Thr Asp 
    1940                 1945                 1950             


Lys Leu  Asn Glu Asn Ser Thr  Pro Glu Lys Thr Asp  Val Thr Pro 
    1955                 1960                 1965             


Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Glu 
    1970                 1975                 1980             


Lys Glu  Lys Phe Glu Lys Asp  Lys Ser Glu Lys Glu  Asp Lys Gly 
    1985                 1990                 1995             


Lys Asp  Ile Arg Glu Ser Lys  Lys 
    2000                 2005     


<210>  52
<211>  2005
<212>  PRT
<213>  Rattus norvegicus

<400>  52

Met Ala Arg Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Val Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asn Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Thr Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Trp Asn Gly 
    290                 295                 300                 


Thr Ala Phe Asn Arg Thr Val Asn Met Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ala Gly Glu Glu Glu Lys Glu Asp Ala Val Arg Lys Ser Ala Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Lys Lys Gly Phe Gln Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Asn Phe Lys Gly Arg Val Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Pro Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Gly Ile Pro Thr Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Val Gly Gln Leu Leu Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser 
        675                 680                 685             


Tyr His Val Ser Met Asp Leu Leu Glu Asp Pro Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Met Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Val Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His His Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Leu Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Ala Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Met Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Gln Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Glu Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Cys Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Ala Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Val Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Asp  Glu Gly Thr Pro Ile  Lys Glu Asp Ile Ile  Thr Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Val  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210>  53
<211>  2021
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  53

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Val Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Val Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Met Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Glu Phe Ser Gly Ala Gly Gly Val 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Glu Asp Gly Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Thr Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Thr Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Thr Gly Gln Leu Leu Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser 
        675                 680                 685             


Tyr His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg 
    690                 695                 700                 


Ala Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met 
                725                 730                 735     


Cys Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu 
            740                 745                 750         


Val Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Phe Val Lys Arg  Lys Ile Arg 
    1010                 1015                 1020             


Glu Phe  Ile Gln Lys Ala Phe  Val Arg Lys Gln Lys  Ala Leu Asp 
    1025                 1030                 1035             


Glu Ile  Lys Pro Leu Glu Asp  Leu Asn Asn Lys Lys  Asp Ser Cys 
    1040                 1045                 1050             


Ile Ser  Asn His Thr Thr Ile  Glu Ile Gly Lys Asp  Leu Asn Tyr 
    1055                 1060                 1065             


Leu Lys  Asp Gly Asn Gly Thr  Thr Ser Gly Ile Gly  Ser Ser Val 
    1070                 1075                 1080             


Glu Lys  Tyr Val Val Asp Glu  Ser Asp Tyr Met Ser  Phe Ile Asn 
    1085                 1090                 1095             


Asn Pro  Ser Leu Thr Val Thr  Val Pro Ile Ala Val  Gly Glu Ser 
    1100                 1105                 1110             


Asp Phe  Glu Asn Leu Asn Thr  Glu Glu Phe Ser Ser  Glu Ser Asp 
    1115                 1120                 1125             


Met Glu  Glu Ser Lys Glu Ile  Lys Glu Asp Ile Glu  Thr Leu Ser 
    1130                 1135                 1140             


Cys Gly  Ile Asp Phe Gln Lys  Leu Asn Ala Thr Ser  Ser Ser Glu 
    1145                 1150                 1155             


Gly Ser  Thr Val Asp Ile Gly  Ala Pro Ala Glu Gly  Glu Gln Pro 
    1160                 1165                 1170             


Glu Ala  Glu Pro Glu Glu Ser  Leu Glu Pro Glu Ala  Cys Phe Thr 
    1175                 1180                 1185             


Glu Asp  Cys Val Arg Lys Phe  Lys Cys Cys Gln Ile  Ser Ile Glu 
    1190                 1195                 1200             


Glu Gly  Lys Gly Lys Leu Trp  Trp Asn Leu Arg Lys  Thr Cys Tyr 
    1205                 1210                 1215             


Lys Ile  Val Glu His Asn Trp  Phe Glu Thr Phe Ile  Val Phe Met 
    1220                 1225                 1230             


Ile Leu  Leu Ser Ser Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile 
    1235                 1240                 1245             


Glu Gln  Arg Lys Thr Ile Lys  Thr Met Leu Glu Tyr  Ala Asp Lys 
    1250                 1255                 1260             


Val Phe  Thr Tyr Ile Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val 
    1265                 1270                 1275             


Ala Tyr  Gly Phe Gln Met Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu 
    1280                 1285                 1290             


Asp Phe  Leu Ile Val Asp Val  Ser Leu Val Ser Leu  Thr Ala Asn 
    1295                 1300                 1305             


Ala Leu  Gly Tyr Ser Glu Leu  Gly Ala Ile Lys Ser  Leu Arg Thr 
    1310                 1315                 1320             


Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly 
    1325                 1330                 1335             


Met Arg  Val Val Val Asn Ala  Leu Leu Gly Ala Ile  Pro Ser Ile 
    1340                 1345                 1350             


Met Asn  Val Leu Leu Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser 
    1355                 1360                 1365             


Ile Met  Gly Val Asn Leu Phe  Ala Gly Lys Phe Tyr  His Cys Ile 
    1370                 1375                 1380             


Asn Phe  Thr Thr Gly Glu Met  Phe Asp Val Ser Val  Val Asn Asn 
    1385                 1390                 1395             


Tyr Ser  Glu Cys Lys Ala Leu  Ile Glu Ser Asn Gln  Thr Ala Arg 
    1400                 1405                 1410             


Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn Val Gly  Leu Gly Tyr 
    1415                 1420                 1425             


Leu Ser  Leu Leu Gln Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile 
    1430                 1435                 1440             


Met Tyr  Ala Ala Val Asp Ser  Arg Asn Val Glu Leu  Gln Pro Lys 
    1445                 1450                 1455             


Tyr Glu  Asp Asn Leu Tyr Met  Tyr Leu Tyr Phe Val  Ile Phe Ile 
    1460                 1465                 1470             


Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile 
    1475                 1480                 1485             


Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys Phe Gly  Gly Gln Asp 
    1490                 1495                 1500             


Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys 
    1505                 1510                 1515             


Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Ala 
    1520                 1525                 1530             


Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe Val Thr  Lys Gln Val 
    1535                 1540                 1545             


Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys Leu Asn  Met Val Thr 
    1550                 1555                 1560             


Met Met  Val Glu Thr Asp Asp  Gln Ser Gln Glu Met  Thr Asn Ile 
    1565                 1570                 1575             


Leu Tyr  Trp Ile Asn Leu Val  Phe Ile Val Leu Phe  Thr Gly Glu 
    1580                 1585                 1590             


Cys Val  Leu Lys Leu Ile Ser  Leu Arg Tyr Tyr Tyr  Phe Thr Ile 
    1595                 1600                 1605             


Gly Trp  Asn Ile Phe Asp Phe  Val Val Val Ile Leu  Ser Ile Val 
    1610                 1615                 1620             


Gly Met  Phe Leu Ala Glu Leu  Ile Glu Lys Tyr Phe  Val Ser Pro 
    1625                 1630                 1635             


Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu 
    1640                 1645                 1650             


Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala 
    1655                 1660                 1665             


Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu 
    1670                 1675                 1680             


Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe 
    1685                 1690                 1695             


Ala Tyr  Val Lys Arg Glu Val  Gly Ile Asp Asp Met  Phe Asn Phe 
    1700                 1705                 1710             


Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr 
    1715                 1720                 1725             


Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Gly 
    1730                 1735                 1740             


Pro Pro  Asp Cys Asp Pro Glu  Lys Asp His Pro Gly  Ser Ser Val 
    1745                 1750                 1755             


Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly Ile Phe  Phe Phe Val 
    1760                 1765                 1770             


Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val Val Asn  Met Tyr Ile 
    1775                 1780                 1785             


Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Ala 
    1790                 1795                 1800             


Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp 
    1805                 1810                 1815             


Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe Ile Glu  Phe Ser Lys 
    1820                 1825                 1830             


Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala 
    1835                 1840                 1845             


Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met Asp Leu  Pro Met Val 
    1850                 1855                 1860             


Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr 
    1865                 1870                 1875             


Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ala  Leu Arg Ile 
    1880                 1885                 1890             


Gln Met  Glu Glu Arg Phe Met  Ala Ser Asn Pro Ser  Lys Val Ser 
    1895                 1900                 1905             


Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg Lys Gln  Glu Glu Val 
    1910                 1915                 1920             


Ser Ala  Ile Val Ile Gln Arg  Ala Tyr Arg Arg Tyr  Leu Leu Lys 
    1925                 1930                 1935             


Gln Lys  Val Lys Lys Val Ser  Ser Ile Tyr Lys Lys  Asp Lys Gly 
    1940                 1945                 1950             


Lys Glu  Gly Asp Gly Thr Pro  Ile Lys Glu Asp Ile  Leu Ile Asp 
    1955                 1960                 1965             


Lys Leu  Asn Glu Asn Ser Thr  Pro Glu Lys Thr Asp  Met Thr Pro 
    1970                 1975                 1980             


Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Glu 
    1985                 1990                 1995             


Lys Glu  Lys Phe Glu Lys Asp  Lys Ser Glu Lys Glu  Asp Lys Gly 
    2000                 2005                 2010             


Lys Asp  Ser Arg Glu Ser Lys  Lys 
    2015                 2020     


<210>  54
<211>  2006
<212>  PRT
<213>  Gallus gallus

<400>  54

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Tyr 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Asn Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Ser Lys Gln Glu Arg Lys Asp Asp Asp Asp Glu Asp 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Thr Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Met Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Thr Phe 
        275                 280                 285             


Glu Thr Thr Val Ile Thr Tyr Phe Asn Ser Ser Ile Gly Glu Asn Gly 
    290                 295                 300                 


Thr Phe Ile Asn Thr Thr Met Thr Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Glu Asn His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Met Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ala Ala Asp Ser Arg Asp Tyr Ser Gly Val Gly Gly Ile 
465                 470                 475                 480 


Gly Gly Phe Ser Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ala Glu Gly Glu Lys Asp Glu Glu Glu Phe Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Lys Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn 
    610                 615                 620                 


Ile Ser Gln Ala Ser Arg Ser Ser Arg Thr Val Pro Pro Leu Pro Val 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Pro Ala Leu Thr Ser Pro Thr Gly Gln Leu Leu Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Asp Leu Arg Lys Arg Arg Ser Ser Ser 
        675                 680                 685             


Tyr Gln Val Pro Met Asp Tyr Leu Thr Asp Pro Ser Ala Arg Gln Arg 
    690                 695                 700                 


Ala Met Ser Ile Ala Ser Met Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Thr 
                725                 730                 735     


Cys Leu Ile Trp Asp Cys Cys Thr Pro Trp Leu Lys Val Lys His Ile 
            740                 745                 750         


Val Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Gly Val Leu Ser Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Ser Ser Asp Cys Glu Leu Pro Arg Trp His Met His Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Ala Arg  Ile Gln Lys Gly Ile  Asp Phe Val Lys Arg  Lys Val Arg 
    1010                 1015                 1020             


Glu Phe  Ile Gln Lys Ala Phe  Val Arg Lys Gln Lys  Val Leu Asp 
    1025                 1030                 1035             


Glu Ile  Lys Pro Leu Glu Asp  Leu Asn Asn Lys Lys  Asp Ser Cys 
    1040                 1045                 1050             


Ile Ser  Asn His Thr Ile Val  Glu Ile Gly Lys Asn  Leu Ala Tyr 
    1055                 1060                 1065             


Leu Lys  Glu Gly Asn Gly Thr  Thr Ser Gly Ile Gly  Ser Ser Val 
    1070                 1075                 1080             


Glu Lys  Tyr Val Val Asp Glu  Ser Asp Tyr Met Ser  Phe Ile Asn 
    1085                 1090                 1095             


Asn Pro  Ser Leu Thr Val Thr  Val Pro Ile Ala Val  Gly Glu Ser 
    1100                 1105                 1110             


Asp Phe  Glu Asn Leu Asn Thr  Glu Glu Phe Ser Ser  Glu Ser Asp 
    1115                 1120                 1125             


Leu Glu  Glu Ser Lys Glu Lys  Leu Asn Ala Ser Ser  Ser Ser Glu 
    1130                 1135                 1140             


Gly Ser  Thr Val Asp Ile Gly  Leu Pro Pro Glu Gly  Glu Gln Pro 
    1145                 1150                 1155             


Glu Val  Glu Pro Glu Glu Ser  Leu Glu Pro Glu Ala  Cys Phe Thr 
    1160                 1165                 1170             


Glu Gly  Cys Val Arg Arg Phe  Lys Cys Cys Gln Val  Ser Val Glu 
    1175                 1180                 1185             


Asp Gly  Lys Gly Lys Ile Trp  Trp Asn Leu Arg Lys  Thr Cys Tyr 
    1190                 1195                 1200             


Lys Ile  Val Glu His Asn Trp  Phe Glu Thr Phe Ile  Val Phe Met 
    1205                 1210                 1215             


Ile Leu  Leu Ser Ser Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile 
    1220                 1225                 1230             


Glu Gln  Arg Lys Thr Ile Lys  Thr Met Leu Glu Tyr  Ala Asp Lys 
    1235                 1240                 1245             


Val Phe  Thr Tyr Ile Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val 
    1250                 1255                 1260             


Ala Tyr  Gly Phe Gln Thr Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu 
    1265                 1270                 1275             


Asp Phe  Leu Ile Val Asp Val  Ser Leu Val Ser Leu  Thr Ala Asn 
    1280                 1285                 1290             


Ala Leu  Gly Tyr Ser Glu Leu  Gly Ala Ile Lys Ser  Leu Arg Thr 
    1295                 1300                 1305             


Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly 
    1310                 1315                 1320             


Met Arg  Val Val Val Asn Ala  Leu Leu Gly Ala Ile  Pro Ser Ile 
    1325                 1330                 1335             


Met Asn  Val Leu Leu Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser 
    1340                 1345                 1350             


Ile Met  Gly Val Asn Leu Phe  Ala Gly Lys Phe Tyr  Tyr Cys Val 
    1355                 1360                 1365             


Asn Thr  Thr Thr Asp Glu Arg  Phe Asp Ile Ser Gln  Ile Asn Asn 
    1370                 1375                 1380             


Tyr Ser  Gln Cys Glu Glu Leu  Ile Lys Asn Asn Glu  Thr Ala Arg 
    1385                 1390                 1395             


Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn Val Gly  Leu Gly Tyr 
    1400                 1405                 1410             


Leu Ser  Leu Leu Gln Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile 
    1415                 1420                 1425             


Met Tyr  Ala Ala Val Asp Ser  Arg Asn Val Leu Asp  Gln Pro Lys 
    1430                 1435                 1440             


Tyr Glu  Asp Asn Leu Tyr Met  Tyr Leu Tyr Phe Val  Ile Phe Ile 
    1445                 1450                 1455             


Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile 
    1460                 1465                 1470             


Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys Phe Gly  Gly Gln Asp 
    1475                 1480                 1485             


Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys 
    1490                 1495                 1500             


Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Ala 
    1505                 1510                 1515             


Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe Val Thr  Lys Gln Ala 
    1520                 1525                 1530             


Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys Leu Asn  Met Val Thr 
    1535                 1540                 1545             


Met Met  Val Glu Thr Asp Asp  Gln Ser Glu Asp Met  Glu Asn Ile 
    1550                 1555                 1560             


Leu Tyr  Trp Ile Asn Leu Val  Phe Ile Val Leu Phe  Thr Gly Glu 
    1565                 1570                 1575             


Phe Val  Leu Lys Leu Ile Ser  Leu Arg His Tyr Tyr  Phe Thr Ile 
    1580                 1585                 1590             


Gly Trp  Asn Ile Phe Asp Phe  Val Val Val Ile Leu  Ser Ile Val 
    1595                 1600                 1605             


Gly Met  Phe Leu Ala Glu Met  Ile Glu Lys Tyr Phe  Val Ser Pro 
    1610                 1615                 1620             


Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu 
    1625                 1630                 1635             


Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala 
    1640                 1645                 1650             


Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu 
    1655                 1660                 1665             


Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe 
    1670                 1675                 1680             


Ala Tyr  Val Lys Arg Glu Val  Gly Ile Asp Asp Met  Phe Asn Phe 
    1685                 1690                 1695             


Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr 
    1700                 1705                 1710             


Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Gly 
    1715                 1720                 1725             


Glu Pro  Asp Cys Asp Pro His  Lys Asp His Pro Gly  Ser Ser Val 
    1730                 1735                 1740             


Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly Ile Phe  Phe Phe Val 
    1745                 1750                 1755             


Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val Val Asn  Met Tyr Ile 
    1760                 1765                 1770             


Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala Thr Glu  Glu Ser Ala 
    1775                 1780                 1785             


Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp 
    1790                 1795                 1800             


Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe Ile Glu  Phe Ser Lys 
    1805                 1810                 1815             


Leu Ser  Asp Phe Ala Ala Ser  Leu Asp Pro Pro Leu  Leu Ile Ala 
    1820                 1825                 1830             


Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met Asp Leu  Pro Met Val 
    1835                 1840                 1845             


Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr 
    1850                 1855                 1860             


Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met Asp Ala  Leu Arg Ile 
    1865                 1870                 1875             


Gln Met  Glu Asp Arg Phe Met  Ala Ala Asn Pro Ser  Lys Val Ser 
    1880                 1885                 1890             


Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg Lys Gln  Glu Glu Val 
    1895                 1900                 1905             


Ser Ala  Val Val Ile Gln Arg  Ala Phe Arg Arg His  Leu Leu Arg 
    1910                 1915                 1920             


Gln Lys  Val Lys Lys Val Ser  Cys Ile Phe Asn Gln  Asp Lys Gly 
    1925                 1930                 1935             


Lys Asp  Glu Asp Asp Leu Pro  Met Lys Glu Asp Met  Ile Met Asp 
    1940                 1945                 1950             


Lys Leu  Asn Glu Asn Ser Thr  Pro Glu Lys Thr Asp  Met Thr Pro 
    1955                 1960                 1965             


Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Asp 
    1970                 1975                 1980             


Lys Asp  Lys Tyr Glu Lys Asp  Lys Ser Glu Lys Glu  Asp Lys Gly 
    1985                 1990                 1995             


Lys Asp  Ser Arg Glu Ser Lys  Lys 
    2000                 2005     


<210>  55
<211>  1867
<212>  PRT
<213>  Ophiophagus hannah

<400>  55

Met Glu Lys Arg Glu Ala Ser Ser Phe Ser Leu Arg Leu Gly Cys Thr 
1               5                   10                  15      


Asp Ala Ser Lys Glu Glu Gln Gly Lys Phe Lys Ala Met Leu Asp Tyr 
            20                  25                  30          


Pro Ala Glu Leu Arg Ala Arg Ala Lys Ser Asn Phe Asn Val Gln Asp 
        35                  40                  45              


Glu Lys Met Ala Gln Thr Leu Leu Val Pro Pro Gly Pro Asp Ser Phe 
    50                  55                  60                  


Arg Phe Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Cys Thr 
65                  70                  75                  80  


Glu Glu Lys Ala Lys Arg Pro Lys Gln Glu His Thr Asp Asn Asp Asp 
                85                  90                  95      


Glu Ser Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Thr Leu 
            100                 105                 110         


Pro Phe Ile Tyr Gly Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu 
        115                 120                 125             


Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
    130                 135                 140                 


Asn Arg Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr 
145                 150                 155                 160 


Ile Leu Thr Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu 
                165                 170                 175     


Gly Val Thr Pro Leu Asn Ile Trp Glu Gln Leu Phe Leu Lys Phe Tyr 
            180                 185                 190         


Leu Leu Leu Asn Ile Lys Ser Val Ser Lys Leu Arg Ser Val Trp Asn 
        195                 200                 205             


Ser Thr Phe Phe Asn Phe His Leu Pro Ala Ser Arg Tyr Thr Phe Thr 
    210                 215                 220                 


Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe 
225                 230                 235                 240 


Cys Leu Glu Gly Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
                245                 250                 255     


Phe Ser Val Ile Leu Met Ala Tyr Val Thr Glu Phe Val Asn Leu Gly 
            260                 265                 270         


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
        275                 280                 285             


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
    290                 295                 300                 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
305                 310                 315                 320 


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Arg 
                325                 330                 335     


His Lys Cys Leu Leu Trp Pro Leu Asp Asn Ala Thr Phe Glu Gly Asn 
            340                 345                 350         


Ile Thr Ser His Phe Asn Ser Thr Glu Gly Glu Asn Asp Thr Phe Val 
        355                 360                 365             


Asn Met Thr Val Thr Thr Phe Asn Trp Glu Glu Tyr Ile Glu Asp Glu 
    370                 375                 380                 


Ser His Phe Tyr Val Leu Glu Gly Gln Arg Asp Ala Leu Leu Cys Gly 
385                 390                 395                 400 


Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Val Cys Ile Lys 
                405                 410                 415     


Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser 
            420                 425                 430         


Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp Glu 
        435                 440                 445             


Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile 
    450                 455                 460                 


Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu 
465                 470                 475                 480 


Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Thr 
                485                 490                 495     


Met Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Leu Glu 
            500                 505                 510         


Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ile Thr Ile Arg Glu Ala 
        515                 520                 525             


Thr His Leu Leu Ile Thr Pro Asn Asn Asn Trp Phe Gly Leu Cys Ser 
    530                 535                 540                 


Val Leu Pro Pro Leu Gln Ser Leu Leu Ser Phe Arg Gly Ser Leu Phe 
545                 550                 555                 560 


Ser Pro Arg Arg Asn Ser Arg Thr Ser Ile Phe Ser Phe Arg Gly Arg 
                565                 570                 575     


Ala Lys Asp Ile Gly Ser Glu Asn Asp Phe Ala Asp Asp Glu His Ser 
            580                 585                 590         


Thr Leu Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu Phe Val Pro Asn 
        595                 600                 605             


Arg Gln Thr Ser Glu Arg Arg Asn Ser Thr Thr Ser Gln Met Ser Leu 
    610                 615                 620                 


Ser Ser Lys Met Val Pro Val Leu Pro Ala Asn Gly Lys Met His Ser 
625                 630                 635                 640 


Thr Val Asp Cys Asn Gly Val Val Ser Leu Met Gly Gly Pro Pro Ala 
                645                 650                 655     


Leu Pro Ser Pro Thr Gly Gln Phe Leu Pro Glu Gly Thr Thr Thr Glu 
            660                 665                 670         


Thr Glu Ile Arg Lys Arg Arg Leu Ser Ser Tyr Gln Ile Ser Met Glu 
        675                 680                 685             


Leu Met Glu Glu Ser Ala Ala Arg Gln Arg Ala Met Ser Ile Ala Ser 
    690                 695                 700                 


Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys 
705                 710                 715                 720 


Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val Phe Leu Ile Trp Asp Cys 
                725                 730                 735     


Trp Ser Pro Trp Leu Lys Val Lys His Ile Val Asn Leu Ile Val Met 
            740                 745                 750         


Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr 
        755                 760                 765             


Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Ser Asp Phe Tyr Gln 
    770                 775                 780                 


Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
785                 790                 795                 800 


Met Ile Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu 
                805                 810                 815     


Gly Trp Asn Ile Phe Asp Gly Ile Ile Val Ser Leu Ser Leu Met Glu 
            820                 825                 830         


Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg 
        835                 840                 845             


Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
    850                 855                 860                 


Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
865                 870                 875                 880 


Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
                885                 890                 895     


Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Glu Asp 
            900                 905                 910         


Cys Glu Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu 
        915                 920                 925             


Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
    930                 935                 940                 


Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu Ile Val Phe Met Leu 
945                 950                 955                 960 


Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
                965                 970                 975     


Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala Ala Thr Asp Asp Asp 
            980                 985                 990         


Asn Glu Thr Asn Asn Leu Gln Ile  Ala Val Ala Arg Ile  Gln Lys Gly 
        995                 1000                 1005             


Ile Asp  Tyr Ile Lys Lys Lys  Leu Gly Glu Ile Val  Gln Lys Ser 
    1010                 1015                 1020             


Thr Val  Arg Lys Gln Lys Ala  Ile Asp Asp Ile Lys  Val Phe Glu 
    1025                 1030                 1035             


Glu Leu  Asn His Lys Lys Asp  Val Tyr Ile Ser Asn  His Thr Met 
    1040                 1045                 1050             


Val Glu  Ile Thr Lys Asp Val  Asn Tyr Leu Arg Asp  Gly Asn Gly 
    1055                 1060                 1065             


Thr Thr  Ser Gly Leu Gly Thr  Gly Ser Ser Val Glu  Lys Tyr Ile 
    1070                 1075                 1080             


Ile Asp  Glu Asn Asp Tyr Met  Ser Phe Ile Asn Asn  Pro Gly Leu 
    1085                 1090                 1095             


Thr Val  Thr Val Pro Ile Ala  Val Gly Glu Ser Asp  Phe Glu Asn 
    1100                 1105                 1110             


Ile Asn  Thr Glu Glu Phe Ser  Ser Glu Ser Asp Leu  Glu Gly Ser 
    1115                 1120                 1125             


Lys Glu  Lys Ile Asn Ala Thr  Ser Ser Ser Glu Gly  Ser Thr Val 
    1130                 1135                 1140             


Asp Val  Ala Leu Pro Gly Glu  Gly Glu Gln Ala Glu  Ile Glu Pro 
    1145                 1150                 1155             


Glu Glu  Ala Leu Glu Pro Glu  Ala Cys Phe Thr Glu  Gly Cys Ile 
    1160                 1165                 1170             


Gln Lys  Phe Pro Cys Cys Gln  Val Ser Ile Glu Asp  Gly Lys Gly 
    1175                 1180                 1185             


Lys Ile  Trp Trp Asn Phe Arg  Lys Thr Cys Tyr Ser  Ile Val Glu 
    1190                 1195                 1200             


His Asn  Trp Phe Glu Thr Phe  Ile Val Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Val Glu  Gln Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Thr Met Leu Glu  Tyr Ala Asp Lys Val  Phe Thr Tyr 
    1235                 1240                 1245             


Ile Phe  Ile Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Gln Ile  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Ile Ala Asn Ala  Leu Gly Tyr 
    1280                 1285                 1290             


Ser Glu  Leu Gly Ala Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Ile Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Tyr His Cys Val Asn  Thr Thr Thr 
    1355                 1360                 1365             


Gly Glu  Met Phe Asn Ile Ser  Asp Val Asn Asn Lys  Thr Glu Cys 
    1370                 1375                 1380             


Asp Glu  Leu Ile His Asn Asn  Gln Gln Ala Arg Trp  Lys Asn Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Asp Val Glu  Glu Gln Pro Tyr Tyr  Glu Asp Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Leu Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Ile  Arg Gln Asp Ile Phe  Met Thr Glu 
    1475                 1480                 1485             


Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys 
    1490                 1495                 1500             


Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Gly Asn Lys  Phe Gln Gly 
    1505                 1510                 1515             


Leu Val  Phe Asp Phe Val Thr  Lys Gln Ala Phe Asp  Ile Ser Ile 
    1520                 1525                 1530             


Met Ile  Leu Ile Cys Leu Asn  Met Val Thr Met Met  Val Glu Thr 
    1535                 1540                 1545             


Asp Asp  Gln Ser Lys Glu Met  Glu Ile Ile Leu Ser  Arg Ile Asn 
    1550                 1555                 1560             


Leu Val  Phe Ile Ile Leu Phe  Thr Gly Glu Cys Ile  Leu Lys Leu 
    1565                 1570                 1575             


Ile Ser  Leu Arg His Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe 
    1580                 1585                 1590             


Asp Phe  Val Val Val Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala 
    1595                 1600                 1605             


Glu Ile  Ile Glu Lys Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val 
    1610                 1615                 1620             


Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly 
    1625                 1630                 1635             


Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu 
    1640                 1645                 1650             


Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe 
    1655                 1660                 1665             


Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe Ala Tyr  Val Lys Arg 
    1670                 1675                 1680             


Glu Val  Gly Ile Asp Asp Leu  Phe Asn Phe Glu Thr  Phe Gly Asn 
    1685                 1690                 1695             


Ser Met  Leu Cys Leu Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp 
    1700                 1705                 1710             


Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Gly Pro Pro  Asp Cys Asp 
    1715                 1720                 1725             


Pro Glu  Ile Asp His Pro Gly  Ser Ser Val Lys Gly  Asp Cys Gly 
    1730                 1735                 1740             


Asn Pro  Ser Val Gly Ile Phe  Phe Phe Val Ser Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Val Val Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Arg Ala Phe Arg  Arg Phe Leu Leu Lys  Gln Lys Val 
    1775                 1780                 1785             


Lys Lys  Val Thr Ser Met Tyr  Asn Lys Glu Lys Cys  Arg Asp Gly 
    1790                 1795                 1800             


Glu Ile  Leu Pro Ile Lys Asp  Val Thr Ser Asp Arg  Phe Asn Gly 
    1805                 1810                 1815             


Asn Ser  Ser Pro Glu Lys Thr  Asp Glu Ser Ser Ser  Thr Thr Ser 
    1820                 1825                 1830             


Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro Asn Lys  Glu Lys Tyr 
    1835                 1840                 1845             


Glu Lys  Gly Lys Thr Asp Arg  Asp Phe Lys Gly Lys  Asp Ile Lys 
    1850                 1855                 1860             


Ile Ser  Lys Lys 
    1865         


<210>  56
<211>  2019
<212>  PRT
<213>  Chelonia mydas

<400>  56

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe His Tyr 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Ser Lys Gln Glu Arg Lys Asp Asp Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Thr Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Arg 
                85                  90                  95      


Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Val Tyr Met Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Glu Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg His Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Thr Leu 
        275                 280                 285             


Glu Ile Asn Val Ile Ser Tyr Phe Asn Ser Thr Ile Gly Glu Asn Gly 
    290                 295                 300                 


Ser Phe Val Asn Thr Thr Val Ser Thr Phe Asn Trp Glu Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Arg Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Met Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Val Ala Ala Asp Ser Arg Glu Phe Ser Gly Val Gly Gly 
465                 470                 475                 480 


Val Gly Gly Phe Ser Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser 
                485                 490                 495     


Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys 
            500                 505                 510         


Glu Gln Ser Glu Gly Glu Glu Lys Asp Glu Glu Asp Phe His Lys Ser 
        515                 520                 525             


Glu Ser Glu Asp Ser Met Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu 
    530                 535                 540                 


Gly Asn Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser 
545                 550                 555                 560 


Leu Leu Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Ser Ser Arg 
                565                 570                 575     


Thr Ser Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu 
            580                 585                 590         


Asn Asp Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser 
        595                 600                 605             


Arg Arg Gly Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn 
    610                 615                 620                 


Ser Asn Ile Ser Gln Ala Ser Arg Ser Ser Arg Met Val Pro Ala Leu 
625                 630                 635                 640 


Pro Ala Asn Gly Lys Met His Ser Thr Val Asp Cys Asn Gly Val Val 
                645                 650                 655     


Ser Leu Val Gly Gly Pro Pro Ala Leu Thr Ser Pro Thr Gly Gln Leu 
            660                 665                 670         


Leu Pro Glu Val Ile Ile Ala Ser Lys Ala Thr Gln Glu Asn Gly Thr 
        675                 680                 685             


Thr Thr Glu Thr Glu Leu Arg Lys Arg Arg Thr Ser Ser Tyr His Val 
    690                 695                 700                 


Ser Met Asp Phe Leu Ser Glu Pro Ser Ala Arg Gln Arg Ala Met Ser 
705                 710                 715                 720 


Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu Ser Arg 
                725                 730                 735     


Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Thr Cys Leu Ile 
            740                 745                 750         


Trp Asp Cys Cys Thr Pro Trp Leu Arg Val Lys His Ile Val Asn Leu 
        755                 760                 765             


Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val 
    770                 775                 780                 


Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu Gln 
785                 790                 795                 800 


Phe Ser His Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly Ile Phe 
                805                 810                 815     


Thr Ala Glu Met Phe Leu Lys Ile Val Ala Met Asp Pro Tyr Tyr Tyr 
            820                 825                 830         


Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser Leu Ser 
        835                 840                 845             


Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg 
    850                 855                 860                 


Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr 
865                 870                 875                 880 


Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly 
                885                 890                 895     


Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val 
            900                 905                 910         


Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile 
        915                 920                 925             


Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe Phe His 
    930                 935                 940                 


Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr 
945                 950                 955                 960 


Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val 
                965                 970                 975     


Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe 
            980                 985                 990         


Leu Ala Leu Leu Leu Ser Ser Phe  Ser Ser Asp Asn Leu  Ala Ala Thr 
        995                 1000                 1005             


Asp Asp  Asp Asn Glu Met Asn  Asn Leu Gln Ile Ala  Val Ala Arg 
    1010                 1015                 1020             


Ile Gln  Lys Gly Ile Asp Tyr  Val Lys Arg Lys Ala  Arg Glu Phe 
    1025                 1030                 1035             


Ile Gln  Lys Ala Phe Val Arg  Lys Gln Lys Ala Leu  Asp Glu Ile 
    1040                 1045                 1050             


Lys Pro  Leu Glu Asp Leu Asn  Asn Lys Lys Asp Ser  Cys Ile Ser 
    1055                 1060                 1065             


Asn His  Thr Val Ile Glu Ile  Gly Lys Asp Leu Asn  Tyr Leu Lys 
    1070                 1075                 1080             


Asp Gly  Asn Gly Thr Thr Ser  Gly Val Gly Ser Ser  Val Glu Lys 
    1085                 1090                 1095             


Tyr Val  Val Asp Glu Ser Asp  Tyr Met Ser Phe Ile  Asn Asn Pro 
    1100                 1105                 1110             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Val Gly Glu  Ser Asp Phe 
    1115                 1120                 1125             


Glu Asn  Leu Asn Thr Glu Glu  Phe Ser Ser Glu Ser  Asp Leu Glu 
    1130                 1135                 1140             


Glu Ser  Lys Glu Lys Leu Asn  Ala Ser Ser Ser Ser  Glu Gly Ser 
    1145                 1150                 1155             


Thr Val  Asp Ile Gly Leu Pro  Gln Glu Gly Glu Gln  Pro Glu Ile 
    1160                 1165                 1170             


Glu Pro  Glu Glu Ala Leu Glu  Pro Glu Ala Cys Phe  Thr Glu Gly 
    1175                 1180                 1185             


Cys Val  Arg Lys Phe Lys Cys  Cys Gln Val Ser Thr  Glu Asp Gly 
    1190                 1195                 1200             


Lys Gly  Lys Ile Trp Trp Asn  Leu Arg Lys Thr Cys  Tyr Lys Ile 
    1205                 1210                 1215             


Val Glu  His Asn Trp Phe Glu  Thr Phe Ile Val Phe  Met Ile Leu 
    1220                 1225                 1230             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Gln 
    1235                 1240                 1245             


Arg Lys  Thr Ile Lys Thr Met  Leu Glu Tyr Ala Asp  Lys Val Phe 
    1250                 1255                 1260             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Val Ala Tyr 
    1265                 1270                 1275             


Gly Phe  Gln Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1280                 1285                 1290             


Leu Ile  Val Asp Val Ser Leu  Val Ser Leu Thr Ala  Asn Ala Leu 
    1295                 1300                 1305             


Gly Tyr  Ser Glu Leu Gly Ala  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1310                 1315                 1320             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1325                 1330                 1335             


Val Val  Val Asn Ala Leu Leu  Gly Ala Ile Pro Ser  Ile Met Asn 
    1340                 1345                 1350             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1355                 1360                 1365             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr Tyr Cys  Val Asn Thr 
    1370                 1375                 1380             


Thr Asn  Asp Glu Arg Phe Asp  Ile Ser Gln Ile Asn  Asn Tyr Ser 
    1385                 1390                 1395             


Gln Cys  Glu Asp Leu Ile Asn  Asn Asn Glu Thr Ala  Arg Trp Lys 
    1400                 1405                 1410             


Asn Val  Lys Val Asn Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser 
    1415                 1420                 1425             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Met Asp  Ile Met Tyr 
    1430                 1435                 1440             


Ala Ala  Val Asp Ser Arg Lys  Val Leu Asp Gln Pro  Lys Tyr Glu 
    1445                 1450                 1455             


Asp Asn  Leu Tyr Met Tyr Leu  Tyr Phe Val Ile Phe  Ile Ile Phe 
    1460                 1465                 1470             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1475                 1480                 1485             


Asn Phe  Asn Gln Gln Lys Lys  Lys Phe Gly Gly Gln  Asp Ile Phe 
    1490                 1495                 1500             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1505                 1510                 1515             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Ala Asn Lys 
    1520                 1525                 1530             


Phe Gln  Gly Met Val Phe Asp  Phe Val Thr Lys Gln  Val Phe Asp 
    1535                 1540                 1545             


Ile Ser  Ile Met Ile Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1550                 1555                 1560             


Val Glu  Thr Asp Asn Gln Ser  Asp Glu Met Gln Asp  Asn Leu Trp 
    1565                 1570                 1575             


Trp Ile  Asn Leu Val Phe Ile  Val Leu Phe Thr Gly  Glu Cys Ile 
    1580                 1585                 1590             


Leu Lys  Leu Ile Ser Leu Arg  Tyr Tyr Tyr Phe Thr  Ile Gly Trp 
    1595                 1600                 1605             


Asn Ile  Phe Asp Phe Val Val  Val Ile Leu Ser Ile  Val Gly Met 
    1610                 1615                 1620             


Phe Leu  Ala Asp Leu Ile Glu  Lys Tyr Phe Val Ser  Pro Thr Leu 
    1625                 1630                 1635             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1640                 1645                 1650             


Ile Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1655                 1660                 1665             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1670                 1675                 1680             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1685                 1690                 1695             


Val Lys  Arg Glu Val Gly Ile  Asp Asp Met Phe Asn  Phe Glu Thr 
    1700                 1705                 1710             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1715                 1720                 1725             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Gly Glu Pro 
    1730                 1735                 1740             


Asp Cys  Asp Pro Tyr Lys Asp  His Pro Gly Ser Ser  Val Lys Gly 
    1745                 1750                 1755             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Phe Phe  Val Ser Tyr 
    1760                 1765                 1770             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1775                 1780                 1785             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Ala Glu Pro 
    1790                 1795                 1800             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1805                 1810                 1815             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Phe Ser  Lys Leu Ser 
    1820                 1825                 1830             


Asp Phe  Ala Ala Ser Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1835                 1840                 1845             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1850                 1855                 1860             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1865                 1870                 1875             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Thr Leu Arg  Ile Gln Met 
    1880                 1885                 1890             


Glu Asp  Arg Phe Met Ala Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1895                 1900                 1905             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Glu  Val Ser Ala 
    1910                 1915                 1920             


Val Ile  Ile Gln Arg Ala Phe  Arg Arg Tyr Leu Leu  Lys Gln Lys 
    1925                 1930                 1935             


Ile Lys  Lys Val Ser Cys Met  Phe Asn Gln Asp Lys  Asp Lys Asp 
    1940                 1945                 1950             


Glu Asp  Asp Leu Pro Ile Lys  Glu Asp Met Ile Ile  Asp Lys Leu 
    1955                 1960                 1965             


Asn Glu  Asn Ser Thr Pro Glu  Lys Thr Asp Met Thr  Pro Ser Thr 
    1970                 1975                 1980             


Thr Ser  Pro Pro Ser Tyr Asp  Ser Val Thr Lys Pro  Asp Lys Glu 
    1985                 1990                 1995             


Lys Tyr  Glu Lys Asp Lys Ser  Glu Lys Glu Asp Lys  Gly Lys Asp 
    2000                 2005                 2010             


Val Arg  Glu Ser Lys Lys 
    2015                 


<210>  57
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  57
tcgtcggcag cgtcagatgt gtataagaga cag                                    33


<210>  58
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  58
gtctcgtggg ctcggagatg tgtataagag acag                                   34


