                         SEQUENCE LISTING

<110>  Integrated DNA Technologies, Inc.
 
<120>  LACHNOSPIRACEAE BACTERIUM ND2006 CAS12A MUTANT GENES AND 
       POLYPEPTIDES ENCODED BY sAME

<130>  PA2020-5

<150>  US62808984
<151>  2019-02-22

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
atgagcaaac tggaaaagtt caccaactgt tatagcctga gcaaaaccct gcgttttaaa       60

gcaattccgg ttggtaaaac ccaagagaac attgataata aacgcctgct ggtcgaagat      120

gaaaaacgcg ctgaagatta taaaggcgtg aaaaaactgc tggatcgcta ttatctgagc      180

ttcattaacg atgtgctgca cagcattaaa ctgaagaacc tgaacaacta tatcagcctg      240

tttcgtaaaa aaacccgcac cgaaaaagaa aacaaagagc tggaaaacct ggaaatcaat      300

ctgcgtaaag aaatcgccaa agcgtttaaa ggtaacgagg gttataaaag cctgttcaag      360

aaagacatca tcgaaaccat tctgccggaa tttctggatg ataaagatga aattgccctg      420

gtgaatagct ttaatggctt taccaccgca tttaccggct tttttgataa tcgcgaaaac      480

atgttcagcg aagaagcaaa aagcaccagc attgcatttc gctgcattaa tgaaaatctg      540

acccgctaca ttagcaacat ggatatcttt gaaaaagtgg acgcgatctt cgataaacac      600

gaagtgcaag agatcaaaga gaaaatcctg aacagcgatt atgacgtcga agattttttt      660

gaaggcgagt tctttaactt cgttctgacc caagaaggta tcgacgttta taacgcaatt      720

attggtggtt ttgttaccga aagcggtgag aaaatcaaag gcctgaatga atatatcaac      780

ctgtataacc agaaaaccaa acagaaactg ccgaaattca aaccgctgta taaacaggtt      840

ctgagcgatc gtgaaagcct gagcttttat ggtgaaggtt ataccagtga tgaagaggtt      900

ctggaagttt ttcgtaacac cctgaataaa aacagcgaga tctttagcag catcaaaaag      960

cttgagaaac tgttcaaaaa ctttgatgag tatagcagcg caggcatctt tgttaaaaat     1020

ggtccggcaa ttagcaccat cagcaaagat atttttggcg aatggaatgt gatccgcgat     1080

aaatggaatg ccgaatatga tgatatccac ctgaaaaaaa aggccgtggt gaccgagaaa     1140

tatgaagatg atcgtcgtaa aagcttcaag aaaattggta gctttagcct ggaacagctg     1200

caagaatatg cagatgcaga tctgagcgtt gtggaaaaac tgaaagaaat catcattcag     1260

aaggtggacg agatctataa agtttatggt agcagcgaaa aactgttcga tgcagatttt     1320

gttctggaaa aaagcctgaa aaagaatgat gccgttgtgg ccattatgaa agatctgctg     1380

gatagcgtta agagcttcga gaattacatc aaagcctttt ttggtgaggg caaagaaacc     1440

aatcgtgatg aaagtttcta tggcgatttt gtgctggcct atgatattct gctgaaagtg     1500

gaccatattt atgatgccat tcgcaattat gttacccaga aaccgtatag caaagacaag     1560

ttcaaactgt actttcagaa cccgcagttt atgggtggtt gggataaaga taaagaaacc     1620

gattatcgtg ccaccatcct gcgttatggt agtaaatact atctggccat catggacaaa     1680

aaatacgcaa aatgcctgca gaaaatcgac aaagatgatg tgaatggcaa ctatgaaaaa     1740

atcaactaca aactgctgcc tggtccgaat aaaatgctgc cgaaagtgtt ctttagcaag     1800

aaatggatgg cctattataa cccgagcgag gatattcaaa agatctacaa aaatggcacc     1860

tttaaaaagg gcgacatgtt caatctgaac gattgccaca aactgatcga tttcttcaaa     1920

gattcaattt cgcgttatcc gaaatggtcc aatgcctatg attttaactt tagcgaaacc     1980

gaaaaataca aagacattgc cggtttttat cgcgaagtgg aagaacaggg ctataaagtg     2040

agctttgaaa gcgcaagcaa aaaagaggtt gataagctgg ttgaagaggg caaactgtat     2100

atgttccaga tttacaacaa agattttagc gacaaaagcc atggcacccc gaatctgcat     2160

accatgtact ttaaactgct gttcgacgaa aataaccatg gtcagattcg tctgagcggt     2220

ggtgccgaac tgtttatgcg tcgtgcaagt ctgaaaaaag aagaactggt tgttcatccg     2280

gcaaatagcc cgattgcaaa caaaaatccg gacaatccga aaaaaaccac gacactgagc     2340

tatgatgtgt ataaagacaa acgttttagc gaggatcagt atgaactgca tatcccgatt     2400

gccatcaata aatgcccgaa aaacatcttt aagatcaaca ccgaagttcg cgtgctgctg     2460

aaacatgatg ataatccgta tgtgattggc attgatcgtg gtgaacgtaa cctgctgtat     2520

attgttgttg ttgatggtaa aggcaacatc gtggaacagt atagtctgaa cgaaattatc     2580

aacaacttta acggcatccg catcaaaacc gactatcata gcctgctgga caagaaagaa     2640

aaagaacgtt ttgaagcacg tcagaactgg accagtattg aaaacatcaa agaactgaaa     2700

gccggttata ttagccaggt ggttcataaa atctgtgagc tggtagaaaa atacgatgca     2760

gttattgcac tggaagatct gaatagcggt ttcaaaaata gccgtgtgaa agtcgaaaaa     2820

caggtgtatc agaaattcga gaaaatgctg atcgacaaac tgaactacat ggtcgacaaa     2880

aaaagcaatc cgtgtgcaac cggtggtgca ctgaaaggtt atcagattac caacaaattt     2940

gaaagcttta aaagcatgag cacccagaac ggctttatct tctatattcc ggcatggctg     3000

accagcaaaa ttgatccgag caccggtttt gtgaacctgc tgaaaacaaa atatacctcc     3060

attgccgaca gcaagaagtt tattagcagc tttgatcgca ttatgtatgt tccggaagag     3120

gacctgtttg aattcgcact ggattacaaa aatttcagcc gtaccgatgc cgactacatc     3180

aaaaaatgga aactgtacag ctatggtaac cgcattcgca tttttcgcaa cccgaagaaa     3240

aacaatgtgt tcgattggga agaagtttgt ctgaccagcg catataaaga acttttcaac     3300

aaatacggca tcaactatca gcagggtgat attcgtgcac tgctgtgtga acagagcgat     3360

aaagcgtttt atagcagttt tatggcactg atgagcctga tgctgcagat gcgtaatagc     3420

attaccggtc gcaccgatgt ggattttctg attagtccgg tgaaaaattc cgatggcatc     3480

ttttatgata gccgcaatta cgaagcacaa gaaaatgcaa ttctgccgaa aaacgcagat     3540

gcaaatggtg catataacat tgcacgtaaa gttctgtggg caattggcca gtttaagaaa     3600

gcagaagatg agaagctgga caaagtgaaa attgcgatca gcaataaaga gtggctggaa     3660

tacgcacaga ccagcgttaa acat                                            3684


<210>  2
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Amino Acid

<400>  2

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  3
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Amino Acid

<400>  3

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Arg Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  4
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Amino Acid

<400>  4

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Pro Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  5
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Amino Acid

<400>  5

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Leu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  6
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Amino Acid

<400>  6

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Arg Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Pro Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  7
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Amino Acid

<400>  7

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Arg Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Leu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  8
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Amino Acid

<400>  8

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Pro Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Leu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  9
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Amino Acid

<400>  9

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Arg Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Pro Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Leu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  10
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
atgagcaaac tggaaaagtt caccaactgt tatagcctga gcaaaaccct gcgttttaaa       60

gcaattccgg ttggtaaaac ccaagagaac attgataata aacgcctgct ggtcgaagat      120

gaaaaacgcg ctgaagatta taaaggcgtg aaaaaactgc tggatcgcta ttatctgagc      180

ttcattaacg atgtgctgca cagcattaaa ctgaagaacc tgaacaacta tatcagcctg      240

tttcgtaaaa aaacccgcac cgaaaaagaa aacaaagagc tggaaaacct ggaaatcaat      300

ctgcgtaaag aaatcgccaa agcgtttaaa ggtaacgagg gttataaaag cctgttcaag      360

aaagacatca tcgaaaccat tctgccggaa tttctggatg ataaagatga aattgccctg      420

gtgaatagct ttaatggctt taccaccgca tttaccggct tttttgataa tcgcgaaaac      480

atgttcagcg aagaagcaaa aagcaccagc attgcatttc gctgcattaa tgaaaatctg      540

acccgctaca ttagcaacat ggatatcttt gaaaaagtgg acgcgatctt cgataaacac      600

gaagtgcaag agatcaaaga gaaaatcctg aacagcgatt atgacgtcga agattttttt      660

gaaggcgagt tctttaactt cgttctgacc caagaaggta tcgacgttta taacgcaatt      720

attggtggtt ttgttaccga aagcggtgag aaaatcaaag gcctgaatga atatatcaac      780

ctgtataacc agaaaaccaa acagaaactg ccgaaattca aaccgctgta taaacaggtt      840

ctgagcgatc gtgaaagcct gagcttttat ggtgaaggtt ataccagtga tgaagaggtt      900

ctggaagttt ttcgtaacac cctgaataaa aacagcgaga tctttagcag catcaaaaag      960

cttgagaaac tgttcaaaaa ctttgatgag tatagcagcg caggcatctt tgttaaaaat     1020

ggtccggcaa ttagcaccat cagcaaagat atttttggcg aatggaatgt gatccgcgat     1080

aaatggaatg ccgaatatga tgatatccac ctgaaaaaaa aggccgtggt gaccgagaaa     1140

tatgaagatg atcgtcgtaa aagcttcaag aaaattggta gctttagcct ggaacagctg     1200

caagaatatg cagatgcaga tctgagcgtt gtggaaaaac tgaaagaaat catcattcag     1260

aaggtggacg agatctataa agtttatggt agcagcgaaa aactgttcga tgcagatttt     1320

gttctggaaa aaagcctgaa aaagaatgat gccgttgtgg ccattatgaa agatctgctg     1380

gatagcgtta agagcttcga gaattacatc aaagcctttt ttggtgaggg caaagaaacc     1440

aatcgtgatg aaagtttcta tggcgatttt gtgctggcct atgatattct gctgaaagtg     1500

gaccatattt atgatgccat tcgcaattat gttacccaga aaccgtatag caaagacaag     1560

ttcaaactgt actttcagcg tccgcagttt atgggtggtt gggataaaga taaagaaacc     1620

gattatcgtg ccaccatcct gcgttatggt agtaaatact atctggccat catggacaaa     1680

aaatacgcaa aatgcctgca gaaaatcgac aaagatgatg tgaatggcaa ctatgaaaaa     1740

atcaactaca aactgctgcc tggtccgaat aaaatgctgc cgaaagtgtt ctttagcaag     1800

aaatggatgg cctattataa cccgagcgag gatattcaaa agatctacaa aaatggcacc     1860

tttaaaaagg gcgacatgtt caatctgaac gattgccaca aactgatcga tttcttcaaa     1920

gattcaattt cgcgttatcc gaaatggtcc aatgcctatg attttaactt tagcgaaacc     1980

gaaaaataca aagacattgc cggtttttat cgcgaagtgg aagaacaggg ctataaagtg     2040

agctttgaaa gcgcaagcaa aaaagaggtt gataagctgg ttgaagaggg caaactgtat     2100

atgttccaga tttacaacaa agattttagc gacaaaagcc atggcacccc gaatctgcat     2160

accatgtact ttaaactgct gttcgacgaa aataaccatg gtcagattcg tctgagcggt     2220

ggtgccgaac tgtttatgcg tcgtgcaagt ctgaaaaaag aagaactggt tgttcatccg     2280

gcaaatagcc cgattgcaaa caaaaatccg gacaatccga aaaaaaccac gacactgagc     2340

tatgatgtgt ataaagacaa acgttttagc gaggatcagt atgaactgca tatcccgatt     2400

gccatcaata aatgcccgaa aaacatcttt aagatcaaca ccgaagttcg cgtgctgctg     2460

aaacatgatg ataatccgta tgtgattggc attgatcgtg gtgaacgtaa cctgctgtat     2520

attgttgttg ttgatggtaa aggcaacatc gtggaacagt atagtctgaa cgaaattatc     2580

aacaacttta acggcatccg catcaaaacc gactatcata gcctgctgga caagaaagaa     2640

aaagaacgtt ttgaagcacg tcagaactgg accagtattg aaaacatcaa agaactgaaa     2700

gccggttata ttagccaggt ggttcataaa atctgtgagc tggtagaaaa atacgatgca     2760

gttattgcac tggaagatct gaatagcggt ttcaaaaata gccgtgtgaa agtcgaaaaa     2820

caggtgtatc agaaattcga gaaaatgctg atcgacaaac tgaactacat ggtcgacaaa     2880

aaaagcaatc cgtgtgcaac cggtggtgca ctgaaaggtt atcagattac caacaaattt     2940

gaaagcttta aaagcatgag cacccagaac ggctttatct tctatattcc ggcatggctg     3000

accagcaaaa ttgatccgag caccggtttt gtgaacctgc tgaaaacaaa atatacctcc     3060

attgccgaca gcaagaagtt tattagcagc tttgatcgca ttatgtatgt tccggaagag     3120

gacctgtttg aattcgcact ggattacaaa aatttcagcc gtaccgatgc cgactacatc     3180

aaaaaatgga aactgtacag ctatggtaac cgcattcgca tttttcgcaa cccgaagaaa     3240

aacaatgtgt tcgattggga agaagtttgt ctgaccagcg catataaaga acttttcaac     3300

aaatacggca tcaactatca gcagggtgat attcgtgcac tgctgtgtga acagagcgat     3360

aaagcgtttt atagcagttt tatggcactg atgagcctga tgctgcagat gcgtaatagc     3420

attaccggtc gcaccgatgt ggattttctg attagtccgg tgaaaaattc cgatggcatc     3480

ttttatgata gccgcaatta cgaagcacaa gaaaatgcaa ttctgccgaa aaacgcagat     3540

gcaaatggtg catataacat tgcacgtaaa gttctgtggg caattggcca gtttaagaaa     3600

gcagaagatg agaagctgga caaagtgaaa attgcgatca gcaataaaga gtggctggaa     3660

tacgcacaga ccagcgttaa acat                                            3684


<210>  11
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
atgagcaaac tggaaaagtt caccaactgt tatagcctga gcaaaaccct gcgttttaaa       60

gcaattccgg ttggtaaaac ccaagagaac attgataata aacgcctgct ggtcgaagat      120

gaaaaacgcg ctgaagatta taaaggcgtg aaaaaactgc tggatcgcta ttatctgagc      180

ttcattaacg atgtgctgca cagcattaaa ctgaagaacc tgaacaacta tatcagcctg      240

tttcgtaaaa aaacccgcac cgaaaaagaa aacaaagagc tggaaaacct ggaaatcaat      300

ctgcgtaaag aaatcgccaa agcgtttaaa ggtaacgagg gttataaaag cctgttcaag      360

aaagacatca tcgaaaccat tctgccggaa tttctggatg ataaagatga aattgccctg      420

gtgaatagct ttaatggctt taccaccgca tttaccggct tttttgataa tcgcgaaaac      480

atgttcagcg aagaagcaaa aagcaccagc attgcatttc gctgcattaa tgaaaatctg      540

acccgctaca ttagcaacat ggatatcttt gaaaaagtgg acgcgatctt cgataaacac      600

gaagtgcaag agatcaaaga gaaaatcctg aacagcgatt atgacgtcga agattttttt      660

gaaggcgagt tctttaactt cgttctgacc caagaaggta tcgacgttta taacgcaatt      720

attggtggtt ttgttaccga aagcggtgag aaaatcaaag gcctgaatga atatatcaac      780

ctgtataacc agaaaaccaa acagaaactg ccgaaattca aaccgctgta taaacaggtt      840

ctgagcgatc gtgaaagcct gagcttttat ggtgaaggtt ataccagtga tgaagaggtt      900

ctggaagttt ttcgtaacac cctgaataaa aacagcgaga tctttagcag catcaaaaag      960

cttgagaaac tgttcaaaaa ctttgatgag tatagcagcg caggcatctt tgttaaaaat     1020

ggtccggcaa ttagcaccat cagcaaagat atttttggcg aatggaatgt gatccgcgat     1080

aaatggaatg ccgaatatga tgatatccac ctgaaaaaaa aggccgtggt gaccgagaaa     1140

tatgaagatg atcgtcgtaa aagcttcaag aaaattggta gctttagcct ggaacagctg     1200

caagaatatg cagatgcaga tctgagcgtt gtggaaaaac tgaaagaaat catcattcag     1260

aaggtggacg agatctataa agtttatggt agcagcgaaa aactgttcga tgcagatttt     1320

gttctggaaa aaagcctgaa aaagaatgat gccgttgtgg ccattatgaa agatctgctg     1380

gatagcgtta agagcttcga gaattacatc aaagcctttt ttggtgaggg caaagaaacc     1440

aatcgtgatg aaagtttcta tggcgatttt gtgctggcct atgatattct gctgaaagtg     1500

gaccatattt atgatgccat tcgcaattat gttacccaga aaccgtatag caaagacaag     1560

ttcaaactgt actttcagaa cccgcagttt atgggtggtt gggataaaga taaagaaacc     1620

gattatcgtg ccaccatcct gcgttatggt agtaaatact atctggccat catgccgaaa     1680

aaatacgcaa aatgcctgca gaaaatcgac aaagatgatg tgaatggcaa ctatgaaaaa     1740

atcaactaca aactgctgcc tggtccgaat aaaatgctgc cgaaagtgtt ctttagcaag     1800

aaatggatgg cctattataa cccgagcgag gatattcaaa agatctacaa aaatggcacc     1860

tttaaaaagg gcgacatgtt caatctgaac gattgccaca aactgatcga tttcttcaaa     1920

gattcaattt cgcgttatcc gaaatggtcc aatgcctatg attttaactt tagcgaaacc     1980

gaaaaataca aagacattgc cggtttttat cgcgaagtgg aagaacaggg ctataaagtg     2040

agctttgaaa gcgcaagcaa aaaagaggtt gataagctgg ttgaagaggg caaactgtat     2100

atgttccaga tttacaacaa agattttagc gacaaaagcc atggcacccc gaatctgcat     2160

accatgtact ttaaactgct gttcgacgaa aataaccatg gtcagattcg tctgagcggt     2220

ggtgccgaac tgtttatgcg tcgtgcaagt ctgaaaaaag aagaactggt tgttcatccg     2280

gcaaatagcc cgattgcaaa caaaaatccg gacaatccga aaaaaaccac gacactgagc     2340

tatgatgtgt ataaagacaa acgttttagc gaggatcagt atgaactgca tatcccgatt     2400

gccatcaata aatgcccgaa aaacatcttt aagatcaaca ccgaagttcg cgtgctgctg     2460

aaacatgatg ataatccgta tgtgattggc attgatcgtg gtgaacgtaa cctgctgtat     2520

attgttgttg ttgatggtaa aggcaacatc gtggaacagt atagtctgaa cgaaattatc     2580

aacaacttta acggcatccg catcaaaacc gactatcata gcctgctgga caagaaagaa     2640

aaagaacgtt ttgaagcacg tcagaactgg accagtattg aaaacatcaa agaactgaaa     2700

gccggttata ttagccaggt ggttcataaa atctgtgagc tggtagaaaa atacgatgca     2760

gttattgcac tggaagatct gaatagcggt ttcaaaaata gccgtgtgaa agtcgaaaaa     2820

caggtgtatc agaaattcga gaaaatgctg atcgacaaac tgaactacat ggtcgacaaa     2880

aaaagcaatc cgtgtgcaac cggtggtgca ctgaaaggtt atcagattac caacaaattt     2940

gaaagcttta aaagcatgag cacccagaac ggctttatct tctatattcc ggcatggctg     3000

accagcaaaa ttgatccgag caccggtttt gtgaacctgc tgaaaacaaa atatacctcc     3060

attgccgaca gcaagaagtt tattagcagc tttgatcgca ttatgtatgt tccggaagag     3120

gacctgtttg aattcgcact ggattacaaa aatttcagcc gtaccgatgc cgactacatc     3180

aaaaaatgga aactgtacag ctatggtaac cgcattcgca tttttcgcaa cccgaagaaa     3240

aacaatgtgt tcgattggga agaagtttgt ctgaccagcg catataaaga acttttcaac     3300

aaatacggca tcaactatca gcagggtgat attcgtgcac tgctgtgtga acagagcgat     3360

aaagcgtttt atagcagttt tatggcactg atgagcctga tgctgcagat gcgtaatagc     3420

attaccggtc gcaccgatgt ggattttctg attagtccgg tgaaaaattc cgatggcatc     3480

ttttatgata gccgcaatta cgaagcacaa gaaaatgcaa ttctgccgaa aaacgcagat     3540

gcaaatggtg catataacat tgcacgtaaa gttctgtggg caattggcca gtttaagaaa     3600

gcagaagatg agaagctgga caaagtgaaa attgcgatca gcaataaaga gtggctggaa     3660

tacgcacaga ccagcgttaa acat                                            3684


<210>  12
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
atgagcaaac tggaaaagtt caccaactgt tatagcctga gcaaaaccct gcgttttaaa       60

gcaattccgg ttggtaaaac ccaagagaac attgataata aacgcctgct ggtcgaagat      120

gaaaaacgcg ctgaagatta taaaggcgtg aaaaaactgc tggatcgcta ttatctgagc      180

ttcattaacg atgtgctgca cagcattaaa ctgaagaacc tgaacaacta tatcagcctg      240

tttcgtaaaa aaacccgcac cgaaaaagaa aacaaagagc tggaaaacct ggaaatcaat      300

ctgcgtaaag aaatcgccaa agcgtttaaa ggtaacgagg gttataaaag cctgttcaag      360

aaagacatca tcgaaaccat tctgccggaa tttctggatg ataaagatga aattgccctg      420

gtgaatagct ttaatggctt taccaccgca tttaccggct tttttgataa tcgcgaaaac      480

atgttcagcg aagaagcaaa aagcaccagc attgcatttc gctgcattaa tgaaaatctg      540

acccgctaca ttagcaacat ggatatcttt gaaaaagtgg acgcgatctt cgataaacac      600

gaagtgcaag agatcaaaga gaaaatcctg aacagcgatt atgacgtcga agattttttt      660

gaaggcgagt tctttaactt cgttctgacc caagaaggta tcgacgttta taacgcaatt      720

attggtggtt ttgttaccga aagcggtgag aaaatcaaag gcctgaatga atatatcaac      780

ctgtataacc agaaaaccaa acagaaactg ccgaaattca aaccgctgta taaacaggtt      840

ctgagcgatc gtgaaagcct gagcttttat ggtgaaggtt ataccagtga tgaagaggtt      900

ctggaagttt ttcgtaacac cctgaataaa aacagcgaga tctttagcag catcaaaaag      960

cttgagaaac tgttcaaaaa ctttgatgag tatagcagcg caggcatctt tgttaaaaat     1020

ggtccggcaa ttagcaccat cagcaaagat atttttggcg aatggaatgt gatccgcgat     1080

aaatggaatg ccgaatatga tgatatccac ctgaaaaaaa aggccgtggt gaccgagaaa     1140

tatgaagatg atcgtcgtaa aagcttcaag aaaattggta gctttagcct ggaacagctg     1200

caagaatatg cagatgcaga tctgagcgtt gtggaaaaac tgaaagaaat catcattcag     1260

aaggtggacg agatctataa agtttatggt agcagcgaaa aactgttcga tgcagatttt     1320

gttctggaaa aaagcctgaa aaagaatgat gccgttgtgg ccattatgaa agatctgctg     1380

gatagcgtta agagcttcga gaattacatc aaagcctttt ttggtgaggg caaagaaacc     1440

aatcgtgatg aaagtttcta tggcgatttt gtgctggcct atgatattct gctgaaagtg     1500

gaccatattt atgatgccat tcgcaattat gttacccaga aaccgtatag caaagacaag     1560

ttcaaactgt actttcagaa cccgcagttt atgggtggtt gggataaaga taaagaaacc     1620

gattatcgtg ccaccatcct gcgttatggt agtaaatact atctggccat catggacaaa     1680

aaatacgcaa aatgcctgca gaaaatcgac aaagatgatg tgaatggcaa ctatgaaaaa     1740

atcaactaca aactgctgcc tggtccgaat aaaatgctgc cgaaagtgtt ctttagcaag     1800

aaatggatgg cctattataa cccgagcgag gatattcaaa agatctacaa aaatggcacc     1860

tttaaaaagg gcgacatgtt caatctgaac gattgccaca aactgatcga tttcttcaaa     1920

gattcaattt cgcgttatcc gaaatggtcc aatgcctatg attttaactt tagcgaaacc     1980

gaaaaataca aagacattgc cggtttttat cgcgaagtgg aagaacaggg ctataaagtg     2040

agctttgaaa gcgcaagcaa aaaagaggtt gataagctgg ttgaagaggg caaactgtat     2100

atgttccaga tttacaacaa agattttagc gacaaaagcc atggcacccc gaatctgcat     2160

accatgtact ttaaactgct gttcgacgaa aataaccatg gtcagattcg tctgagcggt     2220

ggtgccgaac tgtttatgcg tcgtgcaagt ctgaaaaaag aagaactggt tgttcatccg     2280

gcaaatagcc cgattgcaaa caaaaatccg gacaatccga aaaaaaccac gacactgagc     2340

tatgatgtgt ataaagacaa acgttttagc gaggatcagt atctgctgca tatcccgatt     2400

gccatcaata aatgcccgaa aaacatcttt aagatcaaca ccgaagttcg cgtgctgctg     2460

aaacatgatg ataatccgta tgtgattggc attgatcgtg gtgaacgtaa cctgctgtat     2520

attgttgttg ttgatggtaa aggcaacatc gtggaacagt atagtctgaa cgaaattatc     2580

aacaacttta acggcatccg catcaaaacc gactatcata gcctgctgga caagaaagaa     2640

aaagaacgtt ttgaagcacg tcagaactgg accagtattg aaaacatcaa agaactgaaa     2700

gccggttata ttagccaggt ggttcataaa atctgtgagc tggtagaaaa atacgatgca     2760

gttattgcac tggaagatct gaatagcggt ttcaaaaata gccgtgtgaa agtcgaaaaa     2820

caggtgtatc agaaattcga gaaaatgctg atcgacaaac tgaactacat ggtcgacaaa     2880

aaaagcaatc cgtgtgcaac cggtggtgca ctgaaaggtt atcagattac caacaaattt     2940

gaaagcttta aaagcatgag cacccagaac ggctttatct tctatattcc ggcatggctg     3000

accagcaaaa ttgatccgag caccggtttt gtgaacctgc tgaaaacaaa atatacctcc     3060

attgccgaca gcaagaagtt tattagcagc tttgatcgca ttatgtatgt tccggaagag     3120

gacctgtttg aattcgcact ggattacaaa aatttcagcc gtaccgatgc cgactacatc     3180

aaaaaatgga aactgtacag ctatggtaac cgcattcgca tttttcgcaa cccgaagaaa     3240

aacaatgtgt tcgattggga agaagtttgt ctgaccagcg catataaaga acttttcaac     3300

aaatacggca tcaactatca gcagggtgat attcgtgcac tgctgtgtga acagagcgat     3360

aaagcgtttt atagcagttt tatggcactg atgagcctga tgctgcagat gcgtaatagc     3420

attaccggtc gcaccgatgt ggattttctg attagtccgg tgaaaaattc cgatggcatc     3480

ttttatgata gccgcaatta cgaagcacaa gaaaatgcaa ttctgccgaa aaacgcagat     3540

gcaaatggtg catataacat tgcacgtaaa gttctgtggg caattggcca gtttaagaaa     3600

gcagaagatg agaagctgga caaagtgaaa attgcgatca gcaataaaga gtggctggaa     3660

tacgcacaga ccagcgttaa acat                                            3684


<210>  13
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
atgagcaaac tggaaaagtt caccaactgt tatagcctga gcaaaaccct gcgttttaaa       60

gcaattccgg ttggtaaaac ccaagagaac attgataata aacgcctgct ggtcgaagat      120

gaaaaacgcg ctgaagatta taaaggcgtg aaaaaactgc tggatcgcta ttatctgagc      180

ttcattaacg atgtgctgca cagcattaaa ctgaagaacc tgaacaacta tatcagcctg      240

tttcgtaaaa aaacccgcac cgaaaaagaa aacaaagagc tggaaaacct ggaaatcaat      300

ctgcgtaaag aaatcgccaa agcgtttaaa ggtaacgagg gttataaaag cctgttcaag      360

aaagacatca tcgaaaccat tctgccggaa tttctggatg ataaagatga aattgccctg      420

gtgaatagct ttaatggctt taccaccgca tttaccggct tttttgataa tcgcgaaaac      480

atgttcagcg aagaagcaaa aagcaccagc attgcatttc gctgcattaa tgaaaatctg      540

acccgctaca ttagcaacat ggatatcttt gaaaaagtgg acgcgatctt cgataaacac      600

gaagtgcaag agatcaaaga gaaaatcctg aacagcgatt atgacgtcga agattttttt      660

gaaggcgagt tctttaactt cgttctgacc caagaaggta tcgacgttta taacgcaatt      720

attggtggtt ttgttaccga aagcggtgag aaaatcaaag gcctgaatga atatatcaac      780

ctgtataacc agaaaaccaa acagaaactg ccgaaattca aaccgctgta taaacaggtt      840

ctgagcgatc gtgaaagcct gagcttttat ggtgaaggtt ataccagtga tgaagaggtt      900

ctggaagttt ttcgtaacac cctgaataaa aacagcgaga tctttagcag catcaaaaag      960

cttgagaaac tgttcaaaaa ctttgatgag tatagcagcg caggcatctt tgttaaaaat     1020

ggtccggcaa ttagcaccat cagcaaagat atttttggcg aatggaatgt gatccgcgat     1080

aaatggaatg ccgaatatga tgatatccac ctgaaaaaaa aggccgtggt gaccgagaaa     1140

tatgaagatg atcgtcgtaa aagcttcaag aaaattggta gctttagcct ggaacagctg     1200

caagaatatg cagatgcaga tctgagcgtt gtggaaaaac tgaaagaaat catcattcag     1260

aaggtggacg agatctataa agtttatggt agcagcgaaa aactgttcga tgcagatttt     1320

gttctggaaa aaagcctgaa aaagaatgat gccgttgtgg ccattatgaa agatctgctg     1380

gatagcgtta agagcttcga gaattacatc aaagcctttt ttggtgaggg caaagaaacc     1440

aatcgtgatg aaagtttcta tggcgatttt gtgctggcct atgatattct gctgaaagtg     1500

gaccatattt atgatgccat tcgcaattat gttacccaga aaccgtatag caaagacaag     1560

ttcaaactgt actttcagcg tccgcagttt atgggtggtt gggataaaga taaagaaacc     1620

gattatcgtg ccaccatcct gcgttatggt agtaaatact atctggccat catgccgaaa     1680

aaatacgcaa aatgcctgca gaaaatcgac aaagatgatg tgaatggcaa ctatgaaaaa     1740

atcaactaca aactgctgcc tggtccgaat aaaatgctgc cgaaagtgtt ctttagcaag     1800

aaatggatgg cctattataa cccgagcgag gatattcaaa agatctacaa aaatggcacc     1860

tttaaaaagg gcgacatgtt caatctgaac gattgccaca aactgatcga tttcttcaaa     1920

gattcaattt cgcgttatcc gaaatggtcc aatgcctatg attttaactt tagcgaaacc     1980

gaaaaataca aagacattgc cggtttttat cgcgaagtgg aagaacaggg ctataaagtg     2040

agctttgaaa gcgcaagcaa aaaagaggtt gataagctgg ttgaagaggg caaactgtat     2100

atgttccaga tttacaacaa agattttagc gacaaaagcc atggcacccc gaatctgcat     2160

accatgtact ttaaactgct gttcgacgaa aataaccatg gtcagattcg tctgagcggt     2220

ggtgccgaac tgtttatgcg tcgtgcaagt ctgaaaaaag aagaactggt tgttcatccg     2280

gcaaatagcc cgattgcaaa caaaaatccg gacaatccga aaaaaaccac gacactgagc     2340

tatgatgtgt ataaagacaa acgttttagc gaggatcagt atgaactgca tatcccgatt     2400

gccatcaata aatgcccgaa aaacatcttt aagatcaaca ccgaagttcg cgtgctgctg     2460

aaacatgatg ataatccgta tgtgattggc attgatcgtg gtgaacgtaa cctgctgtat     2520

attgttgttg ttgatggtaa aggcaacatc gtggaacagt atagtctgaa cgaaattatc     2580

aacaacttta acggcatccg catcaaaacc gactatcata gcctgctgga caagaaagaa     2640

aaagaacgtt ttgaagcacg tcagaactgg accagtattg aaaacatcaa agaactgaaa     2700

gccggttata ttagccaggt ggttcataaa atctgtgagc tggtagaaaa atacgatgca     2760

gttattgcac tggaagatct gaatagcggt ttcaaaaata gccgtgtgaa agtcgaaaaa     2820

caggtgtatc agaaattcga gaaaatgctg atcgacaaac tgaactacat ggtcgacaaa     2880

aaaagcaatc cgtgtgcaac cggtggtgca ctgaaaggtt atcagattac caacaaattt     2940

gaaagcttta aaagcatgag cacccagaac ggctttatct tctatattcc ggcatggctg     3000

accagcaaaa ttgatccgag caccggtttt gtgaacctgc tgaaaacaaa atatacctcc     3060

attgccgaca gcaagaagtt tattagcagc tttgatcgca ttatgtatgt tccggaagag     3120

gacctgtttg aattcgcact ggattacaaa aatttcagcc gtaccgatgc cgactacatc     3180

aaaaaatgga aactgtacag ctatggtaac cgcattcgca tttttcgcaa cccgaagaaa     3240

aacaatgtgt tcgattggga agaagtttgt ctgaccagcg catataaaga acttttcaac     3300

aaatacggca tcaactatca gcagggtgat attcgtgcac tgctgtgtga acagagcgat     3360

aaagcgtttt atagcagttt tatggcactg atgagcctga tgctgcagat gcgtaatagc     3420

attaccggtc gcaccgatgt ggattttctg attagtccgg tgaaaaattc cgatggcatc     3480

ttttatgata gccgcaatta cgaagcacaa gaaaatgcaa ttctgccgaa aaacgcagat     3540

gcaaatggtg catataacat tgcacgtaaa gttctgtggg caattggcca gtttaagaaa     3600

gcagaagatg agaagctgga caaagtgaaa attgcgatca gcaataaaga gtggctggaa     3660

tacgcacaga ccagcgttaa acat                                            3684


<210>  14
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
atgagcaaac tggaaaagtt caccaactgt tatagcctga gcaaaaccct gcgttttaaa       60

gcaattccgg ttggtaaaac ccaagagaac attgataata aacgcctgct ggtcgaagat      120

gaaaaacgcg ctgaagatta taaaggcgtg aaaaaactgc tggatcgcta ttatctgagc      180

ttcattaacg atgtgctgca cagcattaaa ctgaagaacc tgaacaacta tatcagcctg      240

tttcgtaaaa aaacccgcac cgaaaaagaa aacaaagagc tggaaaacct ggaaatcaat      300

ctgcgtaaag aaatcgccaa agcgtttaaa ggtaacgagg gttataaaag cctgttcaag      360

aaagacatca tcgaaaccat tctgccggaa tttctggatg ataaagatga aattgccctg      420

gtgaatagct ttaatggctt taccaccgca tttaccggct tttttgataa tcgcgaaaac      480

atgttcagcg aagaagcaaa aagcaccagc attgcatttc gctgcattaa tgaaaatctg      540

acccgctaca ttagcaacat ggatatcttt gaaaaagtgg acgcgatctt cgataaacac      600

gaagtgcaag agatcaaaga gaaaatcctg aacagcgatt atgacgtcga agattttttt      660

gaaggcgagt tctttaactt cgttctgacc caagaaggta tcgacgttta taacgcaatt      720

attggtggtt ttgttaccga aagcggtgag aaaatcaaag gcctgaatga atatatcaac      780

ctgtataacc agaaaaccaa acagaaactg ccgaaattca aaccgctgta taaacaggtt      840

ctgagcgatc gtgaaagcct gagcttttat ggtgaaggtt ataccagtga tgaagaggtt      900

ctggaagttt ttcgtaacac cctgaataaa aacagcgaga tctttagcag catcaaaaag      960

cttgagaaac tgttcaaaaa ctttgatgag tatagcagcg caggcatctt tgttaaaaat     1020

ggtccggcaa ttagcaccat cagcaaagat atttttggcg aatggaatgt gatccgcgat     1080

aaatggaatg ccgaatatga tgatatccac ctgaaaaaaa aggccgtggt gaccgagaaa     1140

tatgaagatg atcgtcgtaa aagcttcaag aaaattggta gctttagcct ggaacagctg     1200

caagaatatg cagatgcaga tctgagcgtt gtggaaaaac tgaaagaaat catcattcag     1260

aaggtggacg agatctataa agtttatggt agcagcgaaa aactgttcga tgcagatttt     1320

gttctggaaa aaagcctgaa aaagaatgat gccgttgtgg ccattatgaa agatctgctg     1380

gatagcgtta agagcttcga gaattacatc aaagcctttt ttggtgaggg caaagaaacc     1440

aatcgtgatg aaagtttcta tggcgatttt gtgctggcct atgatattct gctgaaagtg     1500

gaccatattt atgatgccat tcgcaattat gttacccaga aaccgtatag caaagacaag     1560

ttcaaactgt actttcagcg tccgcagttt atgggtggtt gggataaaga taaagaaacc     1620

gattatcgtg ccaccatcct gcgttatggt agtaaatact atctggccat catggacaaa     1680

aaatacgcaa aatgcctgca gaaaatcgac aaagatgatg tgaatggcaa ctatgaaaaa     1740

atcaactaca aactgctgcc tggtccgaat aaaatgctgc cgaaagtgtt ctttagcaag     1800

aaatggatgg cctattataa cccgagcgag gatattcaaa agatctacaa aaatggcacc     1860

tttaaaaagg gcgacatgtt caatctgaac gattgccaca aactgatcga tttcttcaaa     1920

gattcaattt cgcgttatcc gaaatggtcc aatgcctatg attttaactt tagcgaaacc     1980

gaaaaataca aagacattgc cggtttttat cgcgaagtgg aagaacaggg ctataaagtg     2040

agctttgaaa gcgcaagcaa aaaagaggtt gataagctgg ttgaagaggg caaactgtat     2100

atgttccaga tttacaacaa agattttagc gacaaaagcc atggcacccc gaatctgcat     2160

accatgtact ttaaactgct gttcgacgaa aataaccatg gtcagattcg tctgagcggt     2220

ggtgccgaac tgtttatgcg tcgtgcaagt ctgaaaaaag aagaactggt tgttcatccg     2280

gcaaatagcc cgattgcaaa caaaaatccg gacaatccga aaaaaaccac gacactgagc     2340

tatgatgtgt ataaagacaa acgttttagc gaggatcagt atctgctgca tatcccgatt     2400

gccatcaata aatgcccgaa aaacatcttt aagatcaaca ccgaagttcg cgtgctgctg     2460

aaacatgatg ataatccgta tgtgattggc attgatcgtg gtgaacgtaa cctgctgtat     2520

attgttgttg ttgatggtaa aggcaacatc gtggaacagt atagtctgaa cgaaattatc     2580

aacaacttta acggcatccg catcaaaacc gactatcata gcctgctgga caagaaagaa     2640

aaagaacgtt ttgaagcacg tcagaactgg accagtattg aaaacatcaa agaactgaaa     2700

gccggttata ttagccaggt ggttcataaa atctgtgagc tggtagaaaa atacgatgca     2760

gttattgcac tggaagatct gaatagcggt ttcaaaaata gccgtgtgaa agtcgaaaaa     2820

caggtgtatc agaaattcga gaaaatgctg atcgacaaac tgaactacat ggtcgacaaa     2880

aaaagcaatc cgtgtgcaac cggtggtgca ctgaaaggtt atcagattac caacaaattt     2940

gaaagcttta aaagcatgag cacccagaac ggctttatct tctatattcc ggcatggctg     3000

accagcaaaa ttgatccgag caccggtttt gtgaacctgc tgaaaacaaa atatacctcc     3060

attgccgaca gcaagaagtt tattagcagc tttgatcgca ttatgtatgt tccggaagag     3120

gacctgtttg aattcgcact ggattacaaa aatttcagcc gtaccgatgc cgactacatc     3180

aaaaaatgga aactgtacag ctatggtaac cgcattcgca tttttcgcaa cccgaagaaa     3240

aacaatgtgt tcgattggga agaagtttgt ctgaccagcg catataaaga acttttcaac     3300

aaatacggca tcaactatca gcagggtgat attcgtgcac tgctgtgtga acagagcgat     3360

aaagcgtttt atagcagttt tatggcactg atgagcctga tgctgcagat gcgtaatagc     3420

attaccggtc gcaccgatgt ggattttctg attagtccgg tgaaaaattc cgatggcatc     3480

ttttatgata gccgcaatta cgaagcacaa gaaaatgcaa ttctgccgaa aaacgcagat     3540

gcaaatggtg catataacat tgcacgtaaa gttctgtggg caattggcca gtttaagaaa     3600

gcagaagatg agaagctgga caaagtgaaa attgcgatca gcaataaaga gtggctggaa     3660

tacgcacaga ccagcgttaa acat                                            3684


<210>  15
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
atgagcaaac tggaaaagtt caccaactgt tatagcctga gcaaaaccct gcgttttaaa       60

gcaattccgg ttggtaaaac ccaagagaac attgataata aacgcctgct ggtcgaagat      120

gaaaaacgcg ctgaagatta taaaggcgtg aaaaaactgc tggatcgcta ttatctgagc      180

ttcattaacg atgtgctgca cagcattaaa ctgaagaacc tgaacaacta tatcagcctg      240

tttcgtaaaa aaacccgcac cgaaaaagaa aacaaagagc tggaaaacct ggaaatcaat      300

ctgcgtaaag aaatcgccaa agcgtttaaa ggtaacgagg gttataaaag cctgttcaag      360

aaagacatca tcgaaaccat tctgccggaa tttctggatg ataaagatga aattgccctg      420

gtgaatagct ttaatggctt taccaccgca tttaccggct tttttgataa tcgcgaaaac      480

atgttcagcg aagaagcaaa aagcaccagc attgcatttc gctgcattaa tgaaaatctg      540

acccgctaca ttagcaacat ggatatcttt gaaaaagtgg acgcgatctt cgataaacac      600

gaagtgcaag agatcaaaga gaaaatcctg aacagcgatt atgacgtcga agattttttt      660

gaaggcgagt tctttaactt cgttctgacc caagaaggta tcgacgttta taacgcaatt      720

attggtggtt ttgttaccga aagcggtgag aaaatcaaag gcctgaatga atatatcaac      780

ctgtataacc agaaaaccaa acagaaactg ccgaaattca aaccgctgta taaacaggtt      840

ctgagcgatc gtgaaagcct gagcttttat ggtgaaggtt ataccagtga tgaagaggtt      900

ctggaagttt ttcgtaacac cctgaataaa aacagcgaga tctttagcag catcaaaaag      960

cttgagaaac tgttcaaaaa ctttgatgag tatagcagcg caggcatctt tgttaaaaat     1020

ggtccggcaa ttagcaccat cagcaaagat atttttggcg aatggaatgt gatccgcgat     1080

aaatggaatg ccgaatatga tgatatccac ctgaaaaaaa aggccgtggt gaccgagaaa     1140

tatgaagatg atcgtcgtaa aagcttcaag aaaattggta gctttagcct ggaacagctg     1200

caagaatatg cagatgcaga tctgagcgtt gtggaaaaac tgaaagaaat catcattcag     1260

aaggtggacg agatctataa agtttatggt agcagcgaaa aactgttcga tgcagatttt     1320

gttctggaaa aaagcctgaa aaagaatgat gccgttgtgg ccattatgaa agatctgctg     1380

gatagcgtta agagcttcga gaattacatc aaagcctttt ttggtgaggg caaagaaacc     1440

aatcgtgatg aaagtttcta tggcgatttt gtgctggcct atgatattct gctgaaagtg     1500

gaccatattt atgatgccat tcgcaattat gttacccaga aaccgtatag caaagacaag     1560

ttcaaactgt actttcagaa cccgcagttt atgggtggtt gggataaaga taaagaaacc     1620

gattatcgtg ccaccatcct gcgttatggt agtaaatact atctggccat catgccgaaa     1680

aaatacgcaa aatgcctgca gaaaatcgac aaagatgatg tgaatggcaa ctatgaaaaa     1740

atcaactaca aactgctgcc tggtccgaat aaaatgctgc cgaaagtgtt ctttagcaag     1800

aaatggatgg cctattataa cccgagcgag gatattcaaa agatctacaa aaatggcacc     1860

tttaaaaagg gcgacatgtt caatctgaac gattgccaca aactgatcga tttcttcaaa     1920

gattcaattt cgcgttatcc gaaatggtcc aatgcctatg attttaactt tagcgaaacc     1980

gaaaaataca aagacattgc cggtttttat cgcgaagtgg aagaacaggg ctataaagtg     2040

agctttgaaa gcgcaagcaa aaaagaggtt gataagctgg ttgaagaggg caaactgtat     2100

atgttccaga tttacaacaa agattttagc gacaaaagcc atggcacccc gaatctgcat     2160

accatgtact ttaaactgct gttcgacgaa aataaccatg gtcagattcg tctgagcggt     2220

ggtgccgaac tgtttatgcg tcgtgcaagt ctgaaaaaag aagaactggt tgttcatccg     2280

gcaaatagcc cgattgcaaa caaaaatccg gacaatccga aaaaaaccac gacactgagc     2340

tatgatgtgt ataaagacaa acgttttagc gaggatcagt atctgctgca tatcccgatt     2400

gccatcaata aatgcccgaa aaacatcttt aagatcaaca ccgaagttcg cgtgctgctg     2460

aaacatgatg ataatccgta tgtgattggc attgatcgtg gtgaacgtaa cctgctgtat     2520

attgttgttg ttgatggtaa aggcaacatc gtggaacagt atagtctgaa cgaaattatc     2580

aacaacttta acggcatccg catcaaaacc gactatcata gcctgctgga caagaaagaa     2640

aaagaacgtt ttgaagcacg tcagaactgg accagtattg aaaacatcaa agaactgaaa     2700

gccggttata ttagccaggt ggttcataaa atctgtgagc tggtagaaaa atacgatgca     2760

gttattgcac tggaagatct gaatagcggt ttcaaaaata gccgtgtgaa agtcgaaaaa     2820

caggtgtatc agaaattcga gaaaatgctg atcgacaaac tgaactacat ggtcgacaaa     2880

aaaagcaatc cgtgtgcaac cggtggtgca ctgaaaggtt atcagattac caacaaattt     2940

gaaagcttta aaagcatgag cacccagaac ggctttatct tctatattcc ggcatggctg     3000

accagcaaaa ttgatccgag caccggtttt gtgaacctgc tgaaaacaaa atatacctcc     3060

attgccgaca gcaagaagtt tattagcagc tttgatcgca ttatgtatgt tccggaagag     3120

gacctgtttg aattcgcact ggattacaaa aatttcagcc gtaccgatgc cgactacatc     3180

aaaaaatgga aactgtacag ctatggtaac cgcattcgca tttttcgcaa cccgaagaaa     3240

aacaatgtgt tcgattggga agaagtttgt ctgaccagcg catataaaga acttttcaac     3300

aaatacggca tcaactatca gcagggtgat attcgtgcac tgctgtgtga acagagcgat     3360

aaagcgtttt atagcagttt tatggcactg atgagcctga tgctgcagat gcgtaatagc     3420

attaccggtc gcaccgatgt ggattttctg attagtccgg tgaaaaattc cgatggcatc     3480

ttttatgata gccgcaatta cgaagcacaa gaaaatgcaa ttctgccgaa aaacgcagat     3540

gcaaatggtg catataacat tgcacgtaaa gttctgtggg caattggcca gtttaagaaa     3600

gcagaagatg agaagctgga caaagtgaaa attgcgatca gcaataaaga gtggctggaa     3660

tacgcacaga ccagcgttaa acat                                            3684


<210>  16
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
atgagcaaac tggaaaagtt caccaactgt tatagcctga gcaaaaccct gcgttttaaa       60

gcaattccgg ttggtaaaac ccaagagaac attgataata aacgcctgct ggtcgaagat      120

gaaaaacgcg ctgaagatta taaaggcgtg aaaaaactgc tggatcgcta ttatctgagc      180

ttcattaacg atgtgctgca cagcattaaa ctgaagaacc tgaacaacta tatcagcctg      240

tttcgtaaaa aaacccgcac cgaaaaagaa aacaaagagc tggaaaacct ggaaatcaat      300

ctgcgtaaag aaatcgccaa agcgtttaaa ggtaacgagg gttataaaag cctgttcaag      360

aaagacatca tcgaaaccat tctgccggaa tttctggatg ataaagatga aattgccctg      420

gtgaatagct ttaatggctt taccaccgca tttaccggct tttttgataa tcgcgaaaac      480

atgttcagcg aagaagcaaa aagcaccagc attgcatttc gctgcattaa tgaaaatctg      540

acccgctaca ttagcaacat ggatatcttt gaaaaagtgg acgcgatctt cgataaacac      600

gaagtgcaag agatcaaaga gaaaatcctg aacagcgatt atgacgtcga agattttttt      660

gaaggcgagt tctttaactt cgttctgacc caagaaggta tcgacgttta taacgcaatt      720

attggtggtt ttgttaccga aagcggtgag aaaatcaaag gcctgaatga atatatcaac      780

ctgtataacc agaaaaccaa acagaaactg ccgaaattca aaccgctgta taaacaggtt      840

ctgagcgatc gtgaaagcct gagcttttat ggtgaaggtt ataccagtga tgaagaggtt      900

ctggaagttt ttcgtaacac cctgaataaa aacagcgaga tctttagcag catcaaaaag      960

cttgagaaac tgttcaaaaa ctttgatgag tatagcagcg caggcatctt tgttaaaaat     1020

ggtccggcaa ttagcaccat cagcaaagat atttttggcg aatggaatgt gatccgcgat     1080

aaatggaatg ccgaatatga tgatatccac ctgaaaaaaa aggccgtggt gaccgagaaa     1140

tatgaagatg atcgtcgtaa aagcttcaag aaaattggta gctttagcct ggaacagctg     1200

caagaatatg cagatgcaga tctgagcgtt gtggaaaaac tgaaagaaat catcattcag     1260

aaggtggacg agatctataa agtttatggt agcagcgaaa aactgttcga tgcagatttt     1320

gttctggaaa aaagcctgaa aaagaatgat gccgttgtgg ccattatgaa agatctgctg     1380

gatagcgtta agagcttcga gaattacatc aaagcctttt ttggtgaggg caaagaaacc     1440

aatcgtgatg aaagtttcta tggcgatttt gtgctggcct atgatattct gctgaaagtg     1500

gaccatattt atgatgccat tcgcaattat gttacccaga aaccgtatag caaagacaag     1560

ttcaaactgt actttcagcg tccgcagttt atgggtggtt gggataaaga taaagaaacc     1620

gattatcgtg ccaccatcct gcgttatggt agtaaatact atctggccat catgccgaaa     1680

aaatacgcaa aatgcctgca gaaaatcgac aaagatgatg tgaatggcaa ctatgaaaaa     1740

atcaactaca aactgctgcc tggtccgaat aaaatgctgc cgaaagtgtt ctttagcaag     1800

aaatggatgg cctattataa cccgagcgag gatattcaaa agatctacaa aaatggcacc     1860

tttaaaaagg gcgacatgtt caatctgaac gattgccaca aactgatcga tttcttcaaa     1920

gattcaattt cgcgttatcc gaaatggtcc aatgcctatg attttaactt tagcgaaacc     1980

gaaaaataca aagacattgc cggtttttat cgcgaagtgg aagaacaggg ctataaagtg     2040

agctttgaaa gcgcaagcaa aaaagaggtt gataagctgg ttgaagaggg caaactgtat     2100

atgttccaga tttacaacaa agattttagc gacaaaagcc atggcacccc gaatctgcat     2160

accatgtact ttaaactgct gttcgacgaa aataaccatg gtcagattcg tctgagcggt     2220

ggtgccgaac tgtttatgcg tcgtgcaagt ctgaaaaaag aagaactggt tgttcatccg     2280

gcaaatagcc cgattgcaaa caaaaatccg gacaatccga aaaaaaccac gacactgagc     2340

tatgatgtgt ataaagacaa acgttttagc gaggatcagt atctgctgca tatcccgatt     2400

gccatcaata aatgcccgaa aaacatcttt aagatcaaca ccgaagttcg cgtgctgctg     2460

aaacatgatg ataatccgta tgtgattggc attgatcgtg gtgaacgtaa cctgctgtat     2520

attgttgttg ttgatggtaa aggcaacatc gtggaacagt atagtctgaa cgaaattatc     2580

aacaacttta acggcatccg catcaaaacc gactatcata gcctgctgga caagaaagaa     2640

aaagaacgtt ttgaagcacg tcagaactgg accagtattg aaaacatcaa agaactgaaa     2700

gccggttata ttagccaggt ggttcataaa atctgtgagc tggtagaaaa atacgatgca     2760

gttattgcac tggaagatct gaatagcggt ttcaaaaata gccgtgtgaa agtcgaaaaa     2820

caggtgtatc agaaattcga gaaaatgctg atcgacaaac tgaactacat ggtcgacaaa     2880

aaaagcaatc cgtgtgcaac cggtggtgca ctgaaaggtt atcagattac caacaaattt     2940

gaaagcttta aaagcatgag cacccagaac ggctttatct tctatattcc ggcatggctg     3000

accagcaaaa ttgatccgag caccggtttt gtgaacctgc tgaaaacaaa atatacctcc     3060

attgccgaca gcaagaagtt tattagcagc tttgatcgca ttatgtatgt tccggaagag     3120

gacctgtttg aattcgcact ggattacaaa aatttcagcc gtaccgatgc cgactacatc     3180

aaaaaatgga aactgtacag ctatggtaac cgcattcgca tttttcgcaa cccgaagaaa     3240

aacaatgtgt tcgattggga agaagtttgt ctgaccagcg catataaaga acttttcaac     3300

aaatacggca tcaactatca gcagggtgat attcgtgcac tgctgtgtga acagagcgat     3360

aaagcgtttt atagcagttt tatggcactg atgagcctga tgctgcagat gcgtaatagc     3420

attaccggtc gcaccgatgt ggattttctg attagtccgg tgaaaaattc cgatggcatc     3480

ttttatgata gccgcaatta cgaagcacaa gaaaatgcaa ttctgccgaa aaacgcagat     3540

gcaaatggtg catataacat tgcacgtaaa gttctgtggg caattggcca gtttaagaaa     3600

gcagaagatg agaagctgga caaagtgaaa attgcgatca gcaataaaga gtggctggaa     3660

tacgcacaga ccagcgttaa acat                                            3684


<210>  17
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
atgacccagt ttgaaggttt caccaatctg tatcaggtta gcaaaaccct gcgttttgaa       60

ctgattccgc agggtaaaac cctgaaacat attcaagaac agggcttcat cgaagaggat      120

aaagcacgta acgatcacta caaagaactg aaaccgatta tcgaccgcat ctataaaacc      180

tatgcagatc agtgtctgca gctggttcag ctggattggg aaaatctgag cgcagcaatt      240

gatagttatc gcaaagaaaa aaccgaagaa acccgtaatg cactgattga agaacaggca      300

acctatcgta atgccatcca tgattatttc attggtcgta ccgataatct gaccgatgca      360

attaacaaac gtcacgccga aatctataaa ggcctgttta aagccgaact gtttaatggc      420

aaagttctga aacagctggg caccgttacc accaccgaac atgaaaatgc actgctgcgt      480

agctttgata aattcaccac ctatttcagc ggcttttatg agaatcgcaa aaacgtgttt      540

agcgcagaag atattagcac cgcaattccg catcgtattg tgcaggataa tttcccgaaa      600

ttcaaagaga actgccacat ttttacccgt ctgattaccg cagttccgag cctgcgtgaa      660

cattttgaaa acgttaaaaa agccatcggc atctttgtta gcaccagcat tgaagaagtt      720

tttagcttcc cgttttacaa tcagctgctg acccagaccc agattgatct gtataaccaa      780

ctgctgggtg gtattagccg tgaagcaggc accgaaaaaa tcaaaggtct gaatgaagtg      840

ctgaatctgg ccattcagaa aaatgatgaa accgcacata ttattgcaag cctgccgcat      900

cgttttattc cgctgttcaa acaaattctg agcgatcgta ataccctgag ctttattctg      960

gaagaattca aatccgatga agaggtgatt cagagctttt gcaaatacaa aacgctgctg     1020

cgcaatgaaa atgttctgga aactgccgaa gcactgttta acgaactgaa tagcattgat     1080

ctgacccaca tctttatcag ccacaaaaaa ctggaaacca tttcaagcgc actgtgtgat     1140

cattgggata ccctgcgtaa tgccctgtat gaacgtcgta ttagcgaact gaccggtaaa     1200

attaccaaaa gcgcgaaaga aaaagttcag cgcagtctga aacatgagga tattaatctg     1260

caagagatta ttagcgcagc cggtaaagaa ctgtcagaag catttaaaca gaaaaccagc     1320

gaaattctgt cacatgcaca tgcagcactg gatcagccgc tgccgaccac cctgaaaaaa     1380

caagaagaaa aagaaatcct gaaaagccag ctggatagcc tgctgggtct gtatcatctg     1440

ctggactggt ttgcagttga tgaaagcaat gaagttgatc cggaatttag cgcacgtctg     1500

accggcatta aactggaaat ggaaccgagc ctgagctttt ataacaaagc ccgtaattat     1560

gccaccaaaa aaccgtatag cgtcgaaaaa ttcaaactga actttcagat gccgaccctg     1620

gcaagcggtt gggatgttaa taaagaaaaa aacaacggtg ccatcctgtt cgtgaaaaat     1680

ggcctgtatt atctgggtat tatgccgaaa cagaaaggtc gttataaagc gctgagcttt     1740

gaaccgacgg aaaaaaccag tgaaggtttt gataaaatgt actacgacta ttttccggat     1800

gcagccaaaa tgattccgaa atgtagcacc cagctgaaag cagttaccgc acattttcag     1860

acccatacca ccccgattct gctgagcaat aactttattg aaccgctgga aatcaccaaa     1920

gagatctacg atctgaataa cccggaaaaa gagccgaaaa aattccagac cgcatatgca     1980

aaaaaaaccg gtgatcagaa aggttatcgt gaagcgctgt gtaaatggat tgatttcacc     2040

cgtgattttc tgagcaaata caccaaaacc accagtatcg atctgagcag cctgcgtccg     2100

agcagccagt ataaagatct gggcgaatat tatgcagaac tgaatccgct gctgtatcat     2160

attagctttc agcgtattgc cgagaaagaa atcatggacg cagttgaaac cggtaaactg     2220

tacctgttcc agatctacaa taaagatttt gccaaaggcc atcatggcaa accgaatctg     2280

cataccctgt attggaccgg tctgtttagc cctgaaaatc tggcaaaaac ctcgattaaa     2340

ctgaatggtc aggcggaact gttttatcgt ccgaaaagcc gtatgaaacg tatggcacat     2400

cgtctgggtg aaaaaatgct gaacaaaaaa ctgaaagacc agaaaacccc gatcccggat     2460

acactgtatc aagaactgta tgattatgtg aaccatcgtc tgagccatga tctgagtgat     2520

gaagcacgtg ccctgctgcc gaatgttatt accaaagaag ttagccacga gatcattaaa     2580

gatcgtcgtt ttaccagcga caaattcttt tttcatgtgc cgattaccct gaattatcag     2640

gcagcaaata gcccgagcaa atttaaccag cgtgttaatg catatctgaa agaacatcca     2700

gaaacgccga ttattggtat tgatcgtggt gaacgtaacc tgatttatat caccgttatt     2760

gatagcaccg gcaaaatcct ggaacagcgt agcctgaata ccattcagca gtttgattac     2820

cagaaaaaac tggataatcg cgagaaagaa cgtgttgcag cacgtcaggc atggtcagtt     2880

gttggtacaa ttaaagacct gaaacagggt tatctgagcc aggttattca tgaaattgtg     2940

gatctgatga ttcactatca ggccgttgtt gtgctggaaa acctgaattt tggctttaaa     3000

agcaaacgta ccggcattgc agaaaaagca gtttatcagc agttcgagaa aatgctgatt     3060

gacaaactga attgcctggt gctgaaagat tatccggctg aaaaagttgg tggtgttctg     3120

aatccgtatc agctgaccga tcagtttacc agctttgcaa aaatgggcac ccagagcgga     3180

tttctgtttt atgttccggc accgtatacg agcaaaattg atccgctgac cggttttgtt     3240

gatccgtttg tttggaaaac catcaaaaac catgaaagcc gcaaacattt tctggaaggt     3300

ttcgattttc tgcattacga cgttaaaacg ggtgatttca tcctgcactt taaaatgaat     3360

cgcaatctga gttttcagcg tggcctgcct ggttttatgc ctgcatggga tattgtgttt     3420

gagaaaaacg aaacacagtt cgatgcaaaa ggcaccccgt ttattgcagg taaacgtatt     3480

gttccggtga ttgaaaatca tcgtttcacc ggtcgttatc gcgatctgta tccggcaaat     3540

gaactgatcg cactgctgga agagaaaggt attgtttttc gtgatggctc aaacattctg     3600

ccgaaactgc tggaaaatga tgatagccat gcaattgata ccatggttgc actgattcgt     3660

agcgttctgc agatgcgtaa tagcaatgca gcaaccggtg aagattacat taatagtccg     3720

gttcgtgatc tgaatggtgt ttgttttgat agccgttttc agaatccgga atggccgatg     3780

gatgcagatg caaatggtgc atatcatatt gcactgaaag gacagctgct gctgaaccac     3840

ctgaaagaaa gcaaagatct gaaactgcaa aacggcatta gcaatcagga ttggctggca     3900

tatatccaag aactgcgtaa c                                               3921


<210>  18
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Amino Acid

<400>  18

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  19
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
atgacccagt ttgaaggttt caccaatctg tatcaggtta gcaaaaccct gcgttttgaa       60

ctgattccgc agggtaaaac cctgaaacat attcaagaac agggcttcat cgaagaggat      120

aaagcacgta acgatcacta caaagaactg aaaccgatta tcgaccgcat ctataaaacc      180

tatgcagatc agtgtctgca gctggttcag ctggattggg aaaatctgag cgcagcaatt      240

gatagttatc gcaaagaaaa aaccgaagaa acccgtaatg cactgattga agaacaggca      300

acctatcgta atgccatcca tgattatttc attggtcgta ccgataatct gaccgatgca      360

attaacaaac gtcacgccga aatctataaa ggcctgttta aagccgaact gtttaatggc      420

aaagttctga aacagctggg caccgttacc accaccgaac atgaaaatgc actgctgcgt      480

agctttgata aattcaccac ctatttcagc ggcttttatg agaatcgcaa aaacgtgttt      540

agcgcagaag atattagcac cgcaattccg catcgtattg tgcaggataa tttcccgaaa      600

ttcaaagaga actgccacat ttttacccgt ctgattaccg cagttccgag cctgcgtgaa      660

cattttgaaa acgttaaaaa agccatcggc atctttgtta gcaccagcat tgaagaagtt      720

tttagcttcc cgttttacaa tcagctgctg acccagaccc agattgatct gtataaccaa      780

ctgctgggtg gtattagccg tgaagcaggc accgaaaaaa tcaaaggtct gaatgaagtg      840

ctgaatctgg ccattcagaa aaatgatgaa accgcacata ttattgcaag cctgccgcat      900

cgttttattc cgctgttcaa acaaattctg agcgatcgta ataccctgag ctttattctg      960

gaagaattca aatccgatga agaggtgatt cagagctttt gcaaatacaa aacgctgctg     1020

cgcaatgaaa atgttctgga aactgccgaa gcactgttta acgaactgaa tagcattgat     1080

ctgacccaca tctttatcag ccacaaaaaa ctggaaacca tttcaagcgc actgtgtgat     1140

cattgggata ccctgcgtaa tgccctgtat gaacgtcgta ttagcgaact gaccggtaaa     1200

attaccaaaa gcgcgaaaga aaaagttcag cgcagtctga aacatgagga tattaatctg     1260

caagagatta ttagcgcagc cggtaaagaa ctgtcagaag catttaaaca gaaaaccagc     1320

gaaattctgt cacatgcaca tgcagcactg gatcagccgc tgccgaccac cctgaaaaaa     1380

caagaagaaa aagaaatcct gaaaagccag ctggatagcc tgctgggtct gtatcatctg     1440

ctggactggt ttgcagttga tgaaagcaat gaagttgatc cggaatttag cgcacgtctg     1500

accggcatta aactggaaat ggaaccgagc ctgagctttt ataacaaagc ccgtaattat     1560

gccaccaaaa aaccgtatag cgtcgaaaaa ttcaaactga actttcagcg tccgaccctg     1620

gcaagcggtt gggatgttaa taaagaaaaa aacaacggtg ccatcctgtt cgtgaaaaat     1680

ggcctgtatt atctgggtat tatgccgaaa cagaaaggtc gttataaagc gctgagcttt     1740

gaaccgacgg aaaaaaccag tgaaggtttt gataaaatgt actacgacta ttttccggat     1800

gcagccaaaa tgattccgaa atgtagcacc cagctgaaag cagttaccgc acattttcag     1860

acccatacca ccccgattct gctgagcaat aactttattg aaccgctgga aatcaccaaa     1920

gagatctacg atctgaataa cccggaaaaa gagccgaaaa aattccagac cgcatatgca     1980

aaaaaaaccg gtgatcagaa aggttatcgt gaagcgctgt gtaaatggat tgatttcacc     2040

cgtgattttc tgagcaaata caccaaaacc accagtatcg atctgagcag cctgcgtccg     2100

agcagccagt ataaagatct gggcgaatat tatgcagaac tgaatccgct gctgtatcat     2160

attagctttc agcgtattgc cgagaaagaa atcatggacg cagttgaaac cggtaaactg     2220

tacctgttcc agatctacaa taaagatttt gccaaaggcc atcatggcaa accgaatctg     2280

cataccctgt attggaccgg tctgtttagc cctgaaaatc tggcaaaaac ctcgattaaa     2340

ctgaatggtc aggcggaact gttttatcgt ccgaaaagcc gtatgaaacg tatggcacat     2400

cgtctgggtg aaaaaatgct gaacaaaaaa ctgaaagacc agaaaacccc gatcccggat     2460

acactgtatc aagaactgta tgattatgtg aaccatcgtc tgagccatga tctgagtgat     2520

gaagcacgtg ccctgctgcc gaatgttatt accaaagaag ttagccacga gatcattaaa     2580

gatcgtcgtt ttaccagcga caaattcctg tttcatgtgc cgattaccct gaattatcag     2640

gcagcaaata gcccgagcaa atttaaccag cgtgttaatg catatctgaa agaacatcca     2700

gaaacgccga ttattggtat tgatcgtggt gaacgtaacc tgatttatat caccgttatt     2760

gatagcaccg gcaaaatcct ggaacagcgt agcctgaata ccattcagca gtttgattac     2820

cagaaaaaac tggataatcg cgagaaagaa cgtgttgcag cacgtcaggc atggtcagtt     2880

gttggtacaa ttaaagacct gaaacagggt tatctgagcc aggttattca tgaaattgtg     2940

gatctgatga ttcactatca ggccgttgtt gtgctggaaa acctgaattt tggctttaaa     3000

agcaaacgta ccggcattgc agaaaaagca gtttatcagc agttcgagaa aatgctgatt     3060

gacaaactga attgcctggt gctgaaagat tatccggctg aaaaagttgg tggtgttctg     3120

aatccgtatc agctgaccga tcagtttacc agctttgcaa aaatgggcac ccagagcgga     3180

tttctgtttt atgttccggc accgtatacg agcaaaattg atccgctgac cggttttgtt     3240

gatccgtttg tttggaaaac catcaaaaac catgaaagcc gcaaacattt tctggaaggt     3300

ttcgattttc tgcattacga cgttaaaacg ggtgatttca tcctgcactt taaaatgaat     3360

cgcaatctga gttttcagcg tggcctgcct ggttttatgc ctgcatggga tattgtgttt     3420

gagaaaaacg aaacacagtt cgatgcaaaa ggcaccccgt ttattgcagg taaacgtatt     3480

gttccggtga ttgaaaatca tcgtttcacc ggtcgttatc gcgatctgta tccggcaaat     3540

gaactgatcg cactgctgga agagaaaggt attgtttttc gtgatggctc aaacattctg     3600

ccgaaactgc tggaaaatga tgatagccat gcaattgata ccatggttgc actgattcgt     3660

agcgttctgc agatgcgtaa tagcaatgca gcaaccggtg aagattacat taatagtccg     3720

gttcgtgatc tgaatggtgt ttgttttgat agccgttttc agaatccgga atggccgatg     3780

gatgcagatg caaatggtgc atatcatatt gcactgaaag gacagctgct gctgaaccac     3840

ctgaaagaaa gcaaagatct gaaactgcaa aacggcatta gcaatcagga ttggctggca     3900

tatatccaag aactgcgtaa c                                               3921


<210>  20
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Amino Acid

<400>  20

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Arg Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Leu Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


