                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  RECOMBINANT ADENO-ASSOCIATED VIRUS FOR TREATMENT OF 
       GRN-ASSOCIATED ADULT-ONSET NEURODEGENERATION

<130>  18-8663PCT

<150>  US 62/809,329
<151>  2019-02-22

<150>  US 62/923,812
<151>  2019-10-21

<150>  US 62/969,108
<151>  2020-02-02

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


<210>  2
<211>  1782
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtggaccc tggtgagctg ggtggcctta acagcagggc tggtggctgg aacgcggtgc       60

ccagatggtc agttctgccc tgtggcctgc tgcctggacc ccggaggagc cagctacagc      120

tgctgccgtc cccttctgga caaatggccc acaacactga gcaggcatct gggtggcccc      180

tgccaggttg atgcccactg ctctgccggc cactcctgca tctttaccgt ctcagggact      240

tccagttgct gccccttccc agaggccgtg gcatgcgggg atggccatca ctgctgccca      300

cggggcttcc actgcagtgc agacgggcga tcctgcttcc aaagatcagg taacaactcc      360

gtgggtgcca tccagtgccc tgatagtcag ttcgaatgcc cggacttctc cacgtgctgt      420

gttatggtcg atggctcctg ggggtgctgc cccatgcccc aggcttcctg ctgtgaagac      480

agggtgcact gctgtccgca cggtgccttc tgcgacctgg ttcacacccg ctgcatcaca      540

cccacgggca cccaccccct ggcaaagaag ctccctgccc agaggactaa cagggcagtg      600

gccttgtcca gctcggtcat gtgtccggac gcacggtccc ggtgccctga tggttctacc      660

tgctgtgagc tgcccagtgg gaagtatggc tgctgcccaa tgcccaacgc cacctgctgc      720

tccgatcacc tgcactgctg cccccaagac actgtgtgtg acctgatcca gagtaagtgc      780

ctctccaagg agaacgctac cacggacctc ctcactaagc tgcctgcgca cacagtgggg      840

gatgtgaaat gtgacatgga ggtgagctgc ccagatggct atacctgctg ccgtctacag      900

tcgggggcct ggggctgctg cccttttacc caggctgtgt gctgtgagga ccacatacac      960

tgctgtcccg cggggtttac gtgtgacacg cagaagggta cctgtgaaca ggggccccac     1020

caggtgccct ggatggagaa ggccccagct cacctcagcc tgccagaccc acaagccttg     1080

aagagagatg tcccctgtga taatgtcagc agctgtccct cctccgatac ctgctgccaa     1140

ctcacgtctg gggagtgggg ctgctgtcca atcccagagg ctgtctgctg ctcggaccac     1200

cagcactgct gcccccaggg ctacacgtgt gtagctgagg ggcagtgtca gcgaggaagc     1260

gagatcgtgg ctggactgga gaagatgcct gcccgccggg cttccttatc ccaccccaga     1320

gacatcggct gtgaccagca caccagctgc ccggtggggc agacctgctg cccgagcctg     1380

ggtgggagct gggcctgctg ccagttgccc catgctgtgt gctgcgagga tcgccagcac     1440

tgctgcccgg ctggctacac ctgcaacgtg aaggctcgat cctgcgagaa ggaagtggtc     1500

tctgcccagc ctgccacctt cctggcccgt agccctcacg tgggtgtgaa ggacgtggag     1560

tgtggggaag gacacttctg ccatgataac cagacctgct gccgagacaa ccgacagggc     1620

tgggcctgct gtccctaccg ccagggcgtc tgttgtgctg atcggcgcca ctgctgtcct     1680

gctggcttcc gctgcgcagc caggggtacc aagtgtttgc gcagggaggc cccgcgctgg     1740

gacgcccctt tgagggaccc agccttgaga cagctgctgt ga                        1782


<210>  3
<211>  1785
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered human PRGN1 coding sequence

<400>  3
atgtggaccc tggtgtcttg ggttgcactg acagctggac tggtggccgg cacaagatgt       60

cctgacggcc agttttgccc cgtggcctgc tgtcttgatc ctggcggagc cagctacagc      120

tgctgcagac ctctgctgga taagtggccc accacactga gcagacacct cggaggacct      180

tgtcaggtgg acgcccactg ttctgccgga cacagctgca tctttaccgt gtctggcacc      240

tccagctgct gtccatttcc tgaggctgtg gcctgcggag acggccacca ctgttgtcct      300

agaggcttcc actgtagcgc cgacggcaga agctgctttc agagaagcgg caacaatagc      360

gtgggcgcca tccagtgtcc tgacagccag ttcgagtgcc ccgacttcag cacctgttgc      420

gtgatggtgg acggcagctg gggctgttgt ccaatgcctc aggctagctg ctgcgaggac      480

agagtgcact gttgccctca cggcgccttt tgcgatctgg tgcacacccg gtgcatcacc      540

ccaacaggca cacatcctct ggccaagaag ctgcctgctc agcggaccaa tagagccgtg      600

gctctgagca gcagcgtgat gtgccctgac gccagatcca ggtgtccaga cggctccaca      660

tgttgcgaac tgcccagcgg caaatacggc tgctgcccca tgcctaacgc cacatgctgt      720

agcgaccatc ttcactgctg cccacaagac accgtgtgcg acctgatcca gagcaagtgc      780

ctgagcaaag agaacgccac caccgacctg ctgaccaaac tgccagctca caccgtggga      840

gatgtgaagt gcgacatgga agtgtcttgc cccgacggct atacctgctg tagactgcaa      900

tctggcgcct ggggctgctg cccttttaca caagctgtgt gttgcgagga ccacatccat      960

tgctgccctg ccggcttcac ctgtgacaca cagaaaggca cctgcgagca gggccctcat     1020

caggtgccat ggatggaaaa agcccctgct cacctgagcc tgcctgatcc tcaagctctg     1080

aagagggacg tgccctgcga caatgtgtct agctgcccta gcagcgacac ctgctgccag     1140

ctgacatctg gcgagtgggg ctgctgtcct ataccagagg ccgtgtgttg ttccgaccac     1200

cagcattgct gtccccaagg ctacacctgt gtggccgaag gccaatgtca acggggctct     1260

gaaattgtgg ccggcctgga aaagatgccc gccagaaggg cttctctgtc tcacccccgg     1320

gacatcggct gcgaccagca cacatcttgt cctgtgggcc agacctgttg tccctctctt     1380

ggtggatcct gggcttgctg tcagctgcct cacgccgtgt gctgcgaaga tagacaacac     1440

tgctgtcccg ccggatacac ctgtaacgtg aaggccagat cctgcgagaa agaagtggtg     1500

tctgcccagc ctgccacctt cctggctaga agtcctcacg tgggcgtgaa ggacgtggag     1560

tgtggcgagg gccacttctg ccacgacaat cagacatgct gcagagacaa ccggcaaggc     1620

tgggcttgtt gcccatatag acagggcgtg tgctgtgccg acagaaggca ctgttgtcca     1680

gccggcttta gatgtgccgc caggggcaca aagtgtctga gaagggaagc ccctaggtgg     1740

gacgcccctc tgagagatcc tgctctgaga cagctgctct gatga                     1785


<210>  4
<211>  1779
<212>  DNA
<213>  Artificial sequence

<220>
<223>  engineered hPRGN2 coding sequence


<220>
<221>  CDS
<222>  (1)..(1779)

<400>  4
atg tgg acc ctg gtt agc tgg gtg gcc ctg acc gcc ggc ctg gtg gcc         48
Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala           
1               5                   10                  15                

ggc acc agg tgc ccc gac ggc cag ttc tgc ccc gtg gcc tgc tgc ctg         96
Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu           
            20                  25                  30                    

gac ccc ggc ggc gcc agc tac agc tgc tgc aga ccc ctg ctg gac aag        144
Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys           
        35                  40                  45                        

tgg ccc acc acc ctg agc aga cac ctg ggc ggc ccc tgc cag gtg gac        192
Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp           
    50                  55                  60                            

gcc cac tgc agc gcc ggc cac agc tgc atc ttc acc gtg agc ggc acc        240
Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr           
65                  70                  75                  80            

agc agc tgc tgc ccc ttc ccc gag gcc gtg gcc tgc ggc gac ggc cac        288
Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His           
                85                  90                  95                

cac tgc tgc ccc aga ggc ttc cac tgc agc gcc gac ggc aga agc tgc        336
His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys           
            100                 105                 110                   

ttc cag aga agc ggc aac aac agc gtg ggc gcc atc cag tgc ccc gac        384
Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp           
        115                 120                 125                       

agc cag ttc gag tgc ccc gac ttc agc acc tgc tgc gtg atg gtg gac        432
Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp           
    130                 135                 140                           

ggc agc tgg ggc tgc tgc ccc atg ccc cag gcc agc tgc tgc gag gac        480
Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp           
145                 150                 155                 160           

aga gtg cac tgc tgc ccc cac ggc gcc ttc tgc gac ctg gtg cac acc        528
Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr           
                165                 170                 175               

agg tgc atc acc ccc acc ggc acc cac ccc ctg gcc aag aag ctg ccc        576
Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro           
            180                 185                 190                   

gcc cag aga acc aac aga gcc gtg gcc ctg agc agc agc gtg atg tgc        624
Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys           
        195                 200                 205                       

ccc gac gcc aga agc agg tgc ccc gac ggc agc acc tgc tgc gag ctg        672
Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu           
    210                 215                 220                           

ccc agc ggc aag tac ggc tgc tgc ccc atg ccc aac gcc acc tgc tgc        720
Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys           
225                 230                 235                 240           

agc gac cac ctg cac tgc tgc ccc caa gac acc gtg tgc gac ctg atc        768
Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile           
                245                 250                 255               

cag agc aag tgc ctg agc aag gag aac gcc acc acc gac ctg ctg acc        816
Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr           
            260                 265                 270                   

aag ctg ccc gcc cac acc gtg ggc gac gtg aag tgc gac atg gag gtt        864
Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val           
        275                 280                 285                       

agc tgt ccc gac ggc tac acc tgc tgc aga ctg cag agc ggc gcc tgg        912
Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp           
    290                 295                 300                           

ggc tgc tgc ccc ttc acc caa gcc gtg tgc tgc gag gac cac atc cac        960
Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His           
305                 310                 315                 320           

tgc tgc ccc gcc ggc ttc acc tgc gac acc cag aag ggc acc tgc gag       1008
Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu           
                325                 330                 335               

cag ggc ccc cac cag gtg ccc tgg atg gag aag gcc ccc gcc cac ctg       1056
Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu           
            340                 345                 350                   

agc ctg ccc gac ccc cag gcc ctg aag aga gac gtg ccc tgc gac aac       1104
Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn           
        355                 360                 365                       

gtt agc agc tgc ccc agc agc gac acc tgc tgc cag ctg acc agc ggc       1152
Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly           
    370                 375                 380                           

gag tgg ggc tgc tgc ccc atc ccc gag gcc gtg tgc tgc agc gac cac       1200
Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His           
385                 390                 395                 400           

cag cac tgc tgc ccc caa ggc tac acc tgc gtg gcc gag ggc cag tgc       1248
Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys           
                405                 410                 415               

cag aga ggc agc gag atc gtg gcc ggc ctg gag aag atg ccc gcc aga       1296
Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg           
            420                 425                 430                   

aga gcc agc ctg agc cac ccc aga gac atc ggc tgc gac cag cac acc       1344
Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr           
        435                 440                 445                       

agc tgc ccc gtg ggc cag acc tgc tgc ccc agc ctg ggc ggc agc tgg       1392
Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp           
    450                 455                 460                           

gcc tgc tgc cag ctg ccc cac gcc gtg tgc tgc gag gac aga cag cac       1440
Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His           
465                 470                 475                 480           

tgc tgc ccc gcc ggc tac acc tgc aac gtg aag gcc aga agc tgc gag       1488
Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu           
                485                 490                 495               

aag gag gtg gtg agc gcc cag ccc gcc acc ttc ctg gcc aga agc ccc       1536
Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro           
            500                 505                 510                   

cac gtg ggc gtg aag gac gtg gag tgc ggc gag ggc cac ttc tgc cac       1584
His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His           
        515                 520                 525                       

gac aac cag acc tgc tgc aga gac aac aga cag ggc tgg gcc tgc tgc       1632
Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys           
    530                 535                 540                           

ccc tac aga cag ggc gtg tgc tgc gcc gac aga aga cac tgc tgc ccc       1680
Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro           
545                 550                 555                 560           

gcc gga ttt agg tgc gcc gcc aga ggc acc aag tgc ctg aga aga gag       1728
Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu           
                565                 570                 575               

gcc ccc agg tgg gac gcc ccc ctg aga gac ccc gcc ctg aga cag ctg       1776
Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu           
            580                 585                 590                   

ctg                                                                   1779
Leu                                                                       
                                                                          


<210>  5
<211>  593
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


<210>  6
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rabbit globin polyA

<400>  6
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210>  7
<211>  130
<212>  DNA
<213>  Artificial sequence

<220>
<223>  3' AAV ITR

<400>  7
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  8
<211>  130
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5' AAV ITR

<400>  8
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  9
<211>  382
<212>  DNA
<213>  Artificial sequence

<220>
<223>  human CMV IE promoter

<400>  9
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg actatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt ac                                               382


<210>  10
<211>  282
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CB promoter

<400>  10
tggtcgaggt gagccccacg ttctgcttca ctctccccat ctcccccccc tccccacccc       60

caattttgta tttatttatt ttttaattat tttgtgcagc gatgggggcg gggggggggg      120

gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg gggcggggcg aggcggagag      180

gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt tccttttatg gcgaggcggc      240

ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc gg                         282


<210>  11
<211>  973
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric intron

<400>  11
gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg       60

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc      120

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc      180

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc      240

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag      300

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg      360

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct      420

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg      480

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag      540

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc      600

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag      660

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc      720

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt      780

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc      840

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt      900

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat      960

cattttggca aag                                                         973


<210>  12
<211>  1227
<212>  DNA
<213>  Artificial sequence

<220>
<223>  UbC promoter

<400>  12
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc aggagcgtcc tgatccttcc gcccggacgc tcaggacagc      120

ggcccgctgc tcataagact cggccttaga accccagtat cagcagaagg acattttagg      180

acgggacttg ggtgactcta gggcactggt tttctttcca gagagcggaa caggcgagga      240

aaagtagtcc cttctcggcg attctgcgga gggatctccg tggggcggtg aacgccgatg      300

attatataag gacgcgccgg gtgtggcaca gctagttccg tcgcagccgg gatttgggtc      360

gcggttcttg tttgtggatc gctgtgatcg tcacttggtg agtagcgggc tgctgggctg      420

gccggggctt tcgtggccgc cgggccgctc ggtgggacgg aagcgtgtgg agagaccgcc      480

aagggctgta gtctgggtcc gcgagcaagg ttgccctgaa ctgggggttg gggggagcgc      540

agcaaaatgg cggctgttcc cgagtcttga atggaagacg cttgtgaggc gggctgtgag      600

gtcgttgaaa caaggtgggg ggcatggtgg gcggcaagaa cccaaggtct tgaggccttc      660

gctaatgcgg gaaagctctt attcgggtga gatgggctgg ggcaccatct ggggaccctg      720

acgtgaagtt tgtcactgac tggagaactc ggtttgtcgt ctgttgcggg ggcggcagtt      780

atgcggtgcc gttgggcagt gcacccgtac ctttgggagc gcgcgccctc gtcgtgtcgt      840

gacgtcaccc gttctgttgg cttataatgc agggtggggc cacctgccgg taggtgtgcg      900

gtaggctttt ctccgtcgca ggacgcaggg ttcgggccta gggtaggctc tcctgaatcg      960

acaggcgccg gacctctggt gaggggaggg ataagtgagg cgtcagtttc tttggtcggt     1020

tttatgtacc tatcttctta agtagctgaa gctccggttt tgaactatgc gctcggggtt     1080

ggcgagtgtg ttttgtgaag ttttttaggc accttttgaa atgtaatcat ttgggtcaat     1140

atgtaatttt cagtgttaga ctagtaaatt gtccgctaaa ttctggccgt ttttggcttt     1200

tttgttagac gaagctttat tgcggta                                         1227


<210>  13
<211>  133
<212>  DNA
<213>  Artificial sequence

<220>
<223>  intron

<400>  13
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  14
<211>  232
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SV40 late polyA

<400>  14
cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga       60

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc      120

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag      180

atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat cg              232


<210>  15
<211>  858
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ampicillin resistance gene

<400>  15
atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct       60

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca      120

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc      180

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc      240

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg      300

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta      360

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc      420

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt      480

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg      540

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct      600

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc      660

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct      720

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac      780

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc      840

tcactgatta agcattgg                                                    858


<210>  16
<211>  589
<212>  DNA
<213>  Artificial sequence

<220>
<223>  COL E1 origin

<400>  16
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaa                  589


<210>  17
<211>  1184
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EF-1a promoter

<400>  17
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtga                      1184


<210>  18
<211>  456
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F1 ori

<400>  18
acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg       60

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca      120

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta      180

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc      240

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg      300

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat      360

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta      420

acgcgaattt taacaaaata ttaacgctta caattt                                456


<210>  19
<211>  816
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Kanamycin resistance gene

<400>  19
ttagaaaaac tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat       60

accatatttt tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca      120

taggatggca agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc      180

tattaatttc ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac      240

tgaatccggt gagaatggca aaagcttatg catttctttc cagacttgtt caacaggcca      300

gccattacgc tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg      360

cgcctgagcg agacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga      420

atgcaaccgg cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata      480

ttcttctaat acctggaatg ctgttttccc ggggatcgca gtggtgagta accatgcatc      540

atcaggagta cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt      600

tagtctgacc atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa      660

caactctggc gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac      720

attatcgcga gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg      780

cctcgagcaa gacgtttccc gttgaatatg gctcat                                816


<210>  20
<211>  131
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P5 promoter

<400>  20
gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc       60

tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga ggtttgaacg      120

cgcagccgcc a                                                           131


<210>  21
<211>  295
<212>  DNA
<213>  Artificial seqeuence

<220>
<223>  LacZ promoter

<400>  21
gcggccgcca ccgcggtgga gctccagctt ttgttccctt tagtgagggt taattgcgcg       60

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc      120

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta      180

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca      240

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgc           295


<210>  22
<211>  3852
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EF1a.huPGRN.SV40


<220>
<221>  repeat_region
<222>  (1)..(130)

<400>  22
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcc gatgtacggg ccagatatac gcgttgacat tgattattga ctaggctttt      240

gcaaaaagct ttgcaaagat ggataaagtt ttaaacagag aggaatcttt gcagctaatg      300

gaccttctag gtcttgaaag gagtgcctcg tgaggctccg gtgcccgtca gtgggcagag      360

cgcacatcgc ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc      420

tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt      480

cccgagggtg ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc      540

aacgggtttg ccgccagaac acaggtaagt gccgtgtgtg gttcccgcgg gcctggcctc      600

tttacgggtt atggcccttg cgtgccttga attacttcca cctggctgca gtacgtgatt      660

cttgatcccg agcttcgggt tggaagtggg tgggagagtt cgaggccttg cgcttaagga      720

gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc gctggggccg ccgcgtgcga      780

atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc catttaaaat      840

ttttgatgac ctgctgcgac gctttttttc tggcaagata gtcttgtaaa tgcgggccaa      900

gatctgcaca ctggtatttc ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc      960

cagcgcacat gttcggcgag gcggggcctg cgagcgcggc caccgagaat cggacggggg     1020

tagtctcaag ctggccggcc tgctctggtg cctggcctcg cgccgccgtg tatcgccccg     1080

ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag atggccgctt     1140

cccggccctg ctgcagggag ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt     1200

gagtcaccca cacaaaggaa aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc     1260

acggagtacc gggcgccgtc caggcacctc gattagttct cgagcttttg gagtacgtcg     1320

tctttaggtt ggggggaggg gttttatgcg atggagtttc cccacactga gtgggtggag     1380

actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgc cctttttgag     1440

tttggatctt ggttcattct caagcctcag acagtggttc aaagtttttt tcttccattt     1500

caggtgtcgt gaggaattag cttggtacta atacgactca ctatagggag acccaagctg     1560

gctaggtaag cttggtaccg agctcggatc aattcgccac catgtggacc ctggtgtctt     1620

gggttgcact gacagctgga ctggtggccg gcacaagatg tcctgacggc cagttttgcc     1680

ccgtggcctg ctgtcttgat cctggcggag ccagctacag ctgctgcaga cctctgctgg     1740

ataagtggcc caccacactg agcagacacc tcggaggacc ttgtcaggtg gacgcccact     1800

gttctgccgg acacagctgc atctttaccg tgtctggcac ctccagctgc tgtccatttc     1860

ctgaggctgt ggcctgcgga gacggccacc actgttgtcc tagaggcttc cactgtagcg     1920

ccgacggcag aagctgcttt cagagaagcg gcaacaatag cgtgggcgcc atccagtgtc     1980

ctgacagcca gttcgagtgc cccgacttca gcacctgttg cgtgatggtg gacggcagct     2040

ggggctgttg tccaatgcct caggctagct gctgcgagga cagagtgcac tgttgccctc     2100

acggcgcctt ttgcgatctg gtgcacaccc ggtgcatcac cccaacaggc acacatcctc     2160

tggccaagaa gctgcctgct cagcggacca atagagccgt ggctctgagc agcagcgtga     2220

tgtgccctga cgccagatcc aggtgtccag acggctccac atgttgcgaa ctgcccagcg     2280

gcaaatacgg ctgctgcccc atgcctaacg ccacatgctg tagcgaccat cttcactgct     2340

gcccacaaga caccgtgtgc gacctgatcc agagcaagtg cctgagcaaa gagaacgcca     2400

ccaccgacct gctgaccaaa ctgccagctc acaccgtggg agatgtgaag tgcgacatgg     2460

aagtgtcttg ccccgacggc tatacctgct gtagactgca atctggcgcc tggggctgct     2520

gcccttttac acaagctgtg tgttgcgagg accacatcca ttgctgccct gccggcttca     2580

cctgtgacac acagaaaggc acctgcgagc agggccctca tcaggtgcca tggatggaaa     2640

aagcccctgc tcacctgagc ctgcctgatc ctcaagctct gaagagggac gtgccctgcg     2700

acaatgtgtc tagctgccct agcagcgaca cctgctgcca gctgacatct ggcgagtggg     2760

gctgctgtcc tataccagag gccgtgtgtt gttccgacca ccagcattgc tgtccccaag     2820

gctacacctg tgtggccgaa ggccaatgtc aacggggctc tgaaattgtg gccggcctgg     2880

aaaagatgcc cgccagaagg gcttctctgt ctcacccccg ggacatcggc tgcgaccagc     2940

acacatcttg tcctgtgggc cagacctgtt gtccctctct tggtggatcc tgggcttgct     3000

gtcagctgcc tcacgccgtg tgctgcgaag atagacaaca ctgctgtccc gccggataca     3060

cctgtaacgt gaaggccaga tcctgcgaga aagaagtggt gtctgcccag cctgccacct     3120

tcctggctag aagtcctcac gtgggcgtga aggacgtgga gtgtggcgag ggccacttct     3180

gccacgacaa tcagacatgc tgcagagaca accggcaagg ctgggcttgt tgcccatata     3240

gacagggcgt gtgctgtgcc gacagaaggc actgttgtcc agccggcttt agatgtgccg     3300

ccaggggcac aaagtgtctg agaagggaag cccctaggtg ggacgcccct ctgagagatc     3360

ctgctctgag acagctgctc tgatgaggta cctctagagt cgacccgggc ggcctcgagg     3420

ccgcttcgag cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg     3480

cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt     3540

ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag     3600

ggggagatgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg taaaatcgat     3660

aaggatcttc ctagagcatg gctacgtaga taagtagcat ggcgggttaa tcattaacta     3720

caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     3780

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga     3840

gcgagcgcgc ag                                                         3852


<210>  23
<211>  3972
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ubc.PI.huPGRN.SV40

<400>  23
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatct ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg      240

gcgagcgctg ccacgtcaga cgaagggcgc aggagcgtcc tgatccttcc gcccggacgc      300

tcaggacagc ggcccgctgc tcataagact cggccttaga accccagtat cagcagaagg      360

acattttagg acgggacttg ggtgactcta gggcactggt tttctttcca gagagcggaa      420

caggcgagga aaagtagtcc cttctcggcg attctgcgga gggatctccg tggggcggtg      480

aacgccgatg attatataag gacgcgccgg gtgtggcaca gctagttccg tcgcagccgg      540

gatttgggtc gcggttcttg tttgtggatc gctgtgatcg tcacttggtg agtagcgggc      600

tgctgggctg gccggggctt tcgtggccgc cgggccgctc ggtgggacgg aagcgtgtgg      660

agagaccgcc aagggctgta gtctgggtcc gcgagcaagg ttgccctgaa ctgggggttg      720

gggggagcgc agcaaaatgg cggctgttcc cgagtcttga atggaagacg cttgtgaggc      780

gggctgtgag gtcgttgaaa caaggtgggg ggcatggtgg gcggcaagaa cccaaggtct      840

tgaggccttc gctaatgcgg gaaagctctt attcgggtga gatgggctgg ggcaccatct      900

ggggaccctg acgtgaagtt tgtcactgac tggagaactc ggtttgtcgt ctgttgcggg      960

ggcggcagtt atgcggtgcc gttgggcagt gcacccgtac ctttgggagc gcgcgccctc     1020

gtcgtgtcgt gacgtcaccc gttctgttgg cttataatgc agggtggggc cacctgccgg     1080

taggtgtgcg gtaggctttt ctccgtcgca ggacgcaggg ttcgggccta gggtaggctc     1140

tcctgaatcg acaggcgccg gacctctggt gaggggaggg ataagtgagg cgtcagtttc     1200

tttggtcggt tttatgtacc tatcttctta agtagctgaa gctccggttt tgaactatgc     1260

gctcggggtt ggcgagtgtg ttttgtgaag ttttttaggc accttttgaa atgtaatcat     1320

ttgggtcaat atgtaatttt cagtgttaga ctagtaaatt gtccgctaaa ttctggccgt     1380

ttttggcttt tttgttagac gaagctttat tgcggtagtt tatcacagtt aaattgctaa     1440

cgcagtcagt gcttctgaca caacagtctc gaacttaagc tgcagaagtt ggtcgtgagg     1500

cactgggcag gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg     1560

cttgtcgaga cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat     1620

ccactttgcc tttctctcca caggtgtcca ctcccagttc aattacagct cttaaggcta     1680

gagtacttaa tacgactcac tataggctag aattcgccac catgtggacc ctggtgtctt     1740

gggttgcact gacagctgga ctggtggccg gcacaagatg tcctgacggc cagttttgcc     1800

ccgtggcctg ctgtcttgat cctggcggag ccagctacag ctgctgcaga cctctgctgg     1860

ataagtggcc caccacactg agcagacacc tcggaggacc ttgtcaggtg gacgcccact     1920

gttctgccgg acacagctgc atctttaccg tgtctggcac ctccagctgc tgtccatttc     1980

ctgaggctgt ggcctgcgga gacggccacc actgttgtcc tagaggcttc cactgtagcg     2040

ccgacggcag aagctgcttt cagagaagcg gcaacaatag cgtgggcgcc atccagtgtc     2100

ctgacagcca gttcgagtgc cccgacttca gcacctgttg cgtgatggtg gacggcagct     2160

ggggctgttg tccaatgcct caggctagct gctgcgagga cagagtgcac tgttgccctc     2220

acggcgcctt ttgcgatctg gtgcacaccc ggtgcatcac cccaacaggc acacatcctc     2280

tggccaagaa gctgcctgct cagcggacca atagagccgt ggctctgagc agcagcgtga     2340

tgtgccctga cgccagatcc aggtgtccag acggctccac atgttgcgaa ctgcccagcg     2400

gcaaatacgg ctgctgcccc atgcctaacg ccacatgctg tagcgaccat cttcactgct     2460

gcccacaaga caccgtgtgc gacctgatcc agagcaagtg cctgagcaaa gagaacgcca     2520

ccaccgacct gctgaccaaa ctgccagctc acaccgtggg agatgtgaag tgcgacatgg     2580

aagtgtcttg ccccgacggc tatacctgct gtagactgca atctggcgcc tggggctgct     2640

gcccttttac acaagctgtg tgttgcgagg accacatcca ttgctgccct gccggcttca     2700

cctgtgacac acagaaaggc acctgcgagc agggccctca tcaggtgcca tggatggaaa     2760

aagcccctgc tcacctgagc ctgcctgatc ctcaagctct gaagagggac gtgccctgcg     2820

acaatgtgtc tagctgccct agcagcgaca cctgctgcca gctgacatct ggcgagtggg     2880

gctgctgtcc tataccagag gccgtgtgtt gttccgacca ccagcattgc tgtccccaag     2940

gctacacctg tgtggccgaa ggccaatgtc aacggggctc tgaaattgtg gccggcctgg     3000

aaaagatgcc cgccagaagg gcttctctgt ctcacccccg ggacatcggc tgcgaccagc     3060

acacatcttg tcctgtgggc cagacctgtt gtccctctct tggtggatcc tgggcttgct     3120

gtcagctgcc tcacgccgtg tgctgcgaag atagacaaca ctgctgtccc gccggataca     3180

cctgtaacgt gaaggccaga tcctgcgaga aagaagtggt gtctgcccag cctgccacct     3240

tcctggctag aagtcctcac gtgggcgtga aggacgtgga gtgtggcgag ggccacttct     3300

gccacgacaa tcagacatgc tgcagagaca accggcaagg ctgggcttgt tgcccatata     3360

gacagggcgt gtgctgtgcc gacagaaggc actgttgtcc agccggcttt agatgtgccg     3420

ccaggggcac aaagtgtctg agaagggaag cccctaggtg ggacgcccct ctgagagatc     3480

ctgctctgag acagctgctc tgatgaggta cctctagagt cgacccgggc ggcctcgagg     3540

ccgcttcgag cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg     3600

cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt     3660

ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag     3720

ggggagatgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg taaaatcgat     3780

aaggatcttc ctagagcatg gctacgtaga taagtagcat ggcgggttaa tcattaacta     3840

caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     3900

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga     3960

gcgagcgcgc ag                                                         3972


<210>  24
<211>  4131
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CB7.CI.hPGRN1.rBG


<220>
<221>  misc_feature
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  misc_feature
<222>  (198)..(579)
<223>  CMV IE enhancer

<220>
<221>  misc_feature
<222>  (582)..(863)
<223>  chicken beta-actin promoter

<220>
<221>  misc_feature
<222>  (958)..(1930)
<223>  chimeric intron

<220>
<221>  misc_feature
<222>  (1942)..(3726)
<223>  hPGRN

<220>
<221>  misc_feature
<222>  (3787)..(3913)
<223>  rabbit beta globin poly A

<220>
<221>  misc_feature
<222>  (4002)..(4131)
<223>  3' ITR

<400>  24
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattcgccac catgtggacc ctggtgtctt gggttgcact gacagctgga     1980

ctggtggccg gcacaagatg tcctgacggc cagttttgcc ccgtggcctg ctgtcttgat     2040

cctggcggag ccagctacag ctgctgcaga cctctgctgg ataagtggcc caccacactg     2100

agcagacacc tcggaggacc ttgtcaggtg gacgcccact gttctgccgg acacagctgc     2160

atctttaccg tgtctggcac ctccagctgc tgtccatttc ctgaggctgt ggcctgcgga     2220

gacggccacc actgttgtcc tagaggcttc cactgtagcg ccgacggcag aagctgcttt     2280

cagagaagcg gcaacaatag cgtgggcgcc atccagtgtc ctgacagcca gttcgagtgc     2340

cccgacttca gcacctgttg cgtgatggtg gacggcagct ggggctgttg tccaatgcct     2400

caggctagct gctgcgagga cagagtgcac tgttgccctc acggcgcctt ttgcgatctg     2460

gtgcacaccc ggtgcatcac cccaacaggc acacatcctc tggccaagaa gctgcctgct     2520

cagcggacca atagagccgt ggctctgagc agcagcgtga tgtgccctga cgccagatcc     2580

aggtgtccag acggctccac atgttgcgaa ctgcccagcg gcaaatacgg ctgctgcccc     2640

atgcctaacg ccacatgctg tagcgaccat cttcactgct gcccacaaga caccgtgtgc     2700

gacctgatcc agagcaagtg cctgagcaaa gagaacgcca ccaccgacct gctgaccaaa     2760

ctgccagctc acaccgtggg agatgtgaag tgcgacatgg aagtgtcttg ccccgacggc     2820

tatacctgct gtagactgca atctggcgcc tggggctgct gcccttttac acaagctgtg     2880

tgttgcgagg accacatcca ttgctgccct gccggcttca cctgtgacac acagaaaggc     2940

acctgcgagc agggccctca tcaggtgcca tggatggaaa aagcccctgc tcacctgagc     3000

ctgcctgatc ctcaagctct gaagagggac gtgccctgcg acaatgtgtc tagctgccct     3060

agcagcgaca cctgctgcca gctgacatct ggcgagtggg gctgctgtcc tataccagag     3120

gccgtgtgtt gttccgacca ccagcattgc tgtccccaag gctacacctg tgtggccgaa     3180

ggccaatgtc aacggggctc tgaaattgtg gccggcctgg aaaagatgcc cgccagaagg     3240

gcttctctgt ctcacccccg ggacatcggc tgcgaccagc acacatcttg tcctgtgggc     3300

cagacctgtt gtccctctct tggtggatcc tgggcttgct gtcagctgcc tcacgccgtg     3360

tgctgcgaag atagacaaca ctgctgtccc gccggataca cctgtaacgt gaaggccaga     3420

tcctgcgaga aagaagtggt gtctgcccag cctgccacct tcctggctag aagtcctcac     3480

gtgggcgtga aggacgtgga gtgtggcgag ggccacttct gccacgacaa tcagacatgc     3540

tgcagagaca accggcaagg ctgggcttgt tgcccatata gacagggcgt gtgctgtgcc     3600

gacagaaggc actgttgtcc agccggcttt agatgtgccg ccaggggcac aaagtgtctg     3660

agaagggaag cccctaggtg ggacgcccct ctgagagatc ctgctctgag acagctgctc     3720

tgatgaggta cctctagagt cgacccgggc ggcctcgagg acggggtgaa ctacgcctga     3780

ggatccgatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat     3840

ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg     3900

tgtctctcac tcggaagcaa ttcgttgatc tgaatttcga ccacccataa tacccattac     3960

cctggtagat aagtagcatg gcgggttaat cattaactac aaggaacccc tagtgatgga     4020

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4080

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca g              4131


<210>  25
<211>  2208
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV1 VP1 gene


<220>
<221>  CDS
<222>  (1)..(2208)

<400>  25
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gac ttg aaa cct gga gcc ccg aag ccc         96
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctc ggt ctg gtt gag gaa ggc gct aag acg gct cct gga aag aaa cgt        432
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cag tcg cca caa gag cca gac tcc tcc tcg ggc atc ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly           
145                 150                 155                 160           

aag aca ggc cag cag ccc gct aaa aag aga ctc aat ttt ggt cag act        528
Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac tca gag tca gtc ccc gat cca caa cct ctc gga gaa cct cca        576
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro           
            180                 185                 190                   

gca acc ccc gct gct gtg gga cct act aca atg gct tca ggc ggt ggc        624
Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc        672
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala           
    210                 215                 220                           

tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cgc acc tgg gcc ttg ccc acc tac aat aac cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc agt gct tca acg ggg gcc agc aac gac aac cac        816
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His           
            260                 265                 270                   

tac ttc ggc tac agc acc ccc tgg ggg tat ttt gat ttc aac aga ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttt tca cca cgt gac tgg cag cga ctc atc aac aac aat        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg gga ttc cgg ccc aag aga ctc aac ttc aaa ctc ttc aac atc caa        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gag gtc acg acg aat gat ggc gtc aca acc atc gct aat aac       1008
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt caa gtc ttc tcg gac tcg gag tac cag ctt ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tac gtc ctc ggc tct gcg cac cag ggc tgc ctc cct ccg ttc ccg gcg       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gtg ttc atg att ccg caa tac ggc tac ctg acg ctc aac aat ggc       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agc caa gcc gtg gga cgt tca tcc ttt tac tgc ctg gaa tat ttc cct       1200
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tct cag atg ctg aga acg ggc aac aac ttt acc ttc agc tac acc ttt       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gag gaa gtg cct ttc cac agc agc tac gcg cac agc cag agc ctg gac       1296
Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

cgg ctg atg aat cct ctc atc gac caa tac ctg tat tac ctg aac aga       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg           
        435                 440                 445                       

act caa aat cag tcc gga agt gcc caa aac aag gac ttg ctg ttt agc       1392
Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser           
    450                 455                 460                           

cgt ggg tct cca gct ggc atg tct gtt cag ccc aaa aac tgg cta cct       1440
Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro           
465                 470                 475                 480           

gga ccc tgt tat cgg cag cag cgc gtt tct aaa aca aaa aca gac aac       1488
Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn           
                485                 490                 495               

aac aac agc aat ttt acc tgg act ggt gct tca aaa tat aac ctc aat       1536
Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn           
            500                 505                 510                   

ggg cgt gaa tcc atc atc aac cct ggc act gct atg gcc tca cac aaa       1584
Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys           
        515                 520                 525                       

gac gac gaa gac aag ttc ttt ccc atg agc ggt gtc atg att ttt gga       1632
Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly           
    530                 535                 540                           

aaa gag agc gcc gga gct tca aac act gca ttg gac aat gtc atg att       1680
Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile           
545                 550                 555                 560           

aca gac gaa gag gaa att aaa gcc act aac cct gtg gcc acc gaa aga       1728
Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg           
                565                 570                 575               

ttt ggg acc gtg gca gtc aat ttc cag agc agc agc aca gac cct gcg       1776
Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala           
            580                 585                 590                   

acc gga gat gtg cat gct atg gga gca tta cct ggc atg gtg tgg caa       1824
Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gat aga gac gtg tac ctg cag ggt ccc att tgg gcc aaa att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

aca gat gga cac ttt cac ccg tct cct ctt atg ggc ggc ttt gga ctc       1920
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu           
625                 630                 635                 640           

aag aac ccg cct cct cag atc ctc atc aaa aac acg cct gtt cct gcg       1968
Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

aat cct ccg gcg gag ttt tca gct aca aag ttt gct tca ttc atc acc       2016
Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr           
            660                 665                 670                   

caa tac tcc aca gga caa gtg agt gtg gaa att gaa tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aaa gaa aac agc aag cgc tgg aat ccc gaa gtg cag tac aca tcc aat       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tat gca aaa tct gcc aac gtt gat ttt act gtg gac aac aat gga ctt       2160
Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu           
705                 710                 715                 720           

tat act gag cct cgc ccc att ggc acc cgt tac ctt acc cgt ccc ctg       2208
Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu           
                725                 730                 735               


<210>  26
<211>  736
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  27
<211>  1863
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV2 rep

<400>  27
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc      420

gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa      480

acccagcctg agctccagtg ggcgtggact aatatggaac agtatttaag cgcctgtttg      540

aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact      660

tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag      720

cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg      780

tcccaaatca aggctgcctt ggacaatgcg ggaaagatta tgagcctgac taaaaccgcc      840

cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg gatttataaa      900

attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct gggatgggcc      960

acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac taccgggaag     1020

accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt aaactggacc     1080

aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg ggaggagggg     1140

aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag caaggtgcgc     1200

gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca ccagcagccg     1320

ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga ctttgggaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg     1440

gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc cagtgacgca     1500

gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg     1560

gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca cgtgggcatg     1620

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc     1680

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt     1740

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg     1800

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctttgaa     1860

caa                                                                   1863


<210>  28
<211>  2172
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV5 capsid VP1 gene


<220>
<221>  CDS
<222>  (1)..(2172)

<400>  28
atg tct ttt gtt gat cac cct cca gat tgg ttg gaa gaa gtt ggt gaa         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu           
1               5                   10                  15                

ggt ctt cgc gag ttt ttg ggc ctt gaa gcg ggc cca ccg aaa cca aaa         96
Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aat cag cag cat caa gat caa gcc cgt ggt ctt gtg ctg cct ggt        144
Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aac tat ctc gga ccc gga aac ggt ctc gat cga gga gag cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac agg gca gac gag gtc gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctt gag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc gcc gac gac aca tcc ttc ggg gga aac        336
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gaa gag ggt gct aag acg gcc cct acc gga aag cgg ata        432
Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile           
    130                 135                 140                           

gac gac cac ttt cca aaa aga aag aag gcc cgg acc gaa gag gac tcc        480
Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser           
145                 150                 155                 160           

aag cct tcc acc tcg tca gac gcc gaa gct gga ccc agc gga tcc cag        528
Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln           
                165                 170                 175               

cag ctg caa atc cca gcc caa cca gcc tca agt ttg gga gct gat aca        576
Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr           
            180                 185                 190                   

atg tct gcg gga ggt ggc ggc cca ttg ggc gac aat aac caa ggt gcc        624
Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala           
        195                 200                 205                       

gat gga gtg ggc aat gcc tcg gga gat tgg cat tgc gat tcc acg tgg        672
Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp           
    210                 215                 220                           

atg ggg gac aga gtc gtc acc aag tcc acc cga acc tgg gtg ctg ccc        720
Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro           
225                 230                 235                 240           

agc tac aac aac cac cag tac cga gag atc aaa agc ggc tcc gtc gac        768
Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp           
                245                 250                 255               

gga agc aac gcc aac gcc tac ttt gga tac agc acc ccc tgg ggg tac        816
Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr           
            260                 265                 270                   

ttt gac ttt aac cgc ttc cac agc cac tgg agc ccc cga gac tgg caa        864
Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln           
        275                 280                 285                       

aga ctc atc aac aac tac tgg ggc ttc aga ccc cgg tcc ctc aga gtc        912
Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val           
    290                 295                 300                           

aaa atc ttc aac att caa gtc aaa gag gtc acg gtg cag gac tcc acc        960
Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr           
305                 310                 315                 320           

acc acc atc gcc aac aac ctc acc tcc acc gtc caa gtg ttt acg gac       1008
Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp           
                325                 330                 335               

gac gac tac cag ctg ccc tac gtc gtc ggc aac ggg acc gag gga tgc       1056
Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys           
            340                 345                 350                   

ctg ccg gcc ttc cct ccg cag gtc ttt acg ctg ccg cag tac ggt tac       1104
Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr           
        355                 360                 365                       

gcg acg ctg aac cgc gac aac aca gaa aat ccc acc gag agg agc agc       1152
Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser           
    370                 375                 380                           

ttc ttc tgc cta gag tac ttt ccc agc aag atg ctg aga acg ggc aac       1200
Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn           
385                 390                 395                 400           

aac ttt gag ttt acc tac aac ttt gag gag gtg ccc ttc cac tcc agc       1248
Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser           
                405                 410                 415               

ttc gct ccc agt cag aac ctc ttc aag ctg gcc aac ccg ctg gtg gac       1296
Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp           
            420                 425                 430                   

cag tac ttg tac cgc ttc gtg agc aca aat aac act ggc gga gtc cag       1344
Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln           
        435                 440                 445                       

ttc aac aag aac ctg gcc ggg aga tac gcc aac acc tac aaa aac tgg       1392
Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp           
    450                 455                 460                           

ttc ccg ggg ccc atg ggc cga acc cag ggc tgg aac ctg ggc tcc ggg       1440
Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly           
465                 470                 475                 480           

gtc aac cgc gcc agt gtc agc gcc ttc gcc acg acc aat agg atg gag       1488
Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu           
                485                 490                 495               

ctc gag ggc gcg agt tac cag gtg ccc ccg cag ccg aac ggc atg acc       1536
Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr           
            500                 505                 510                   

aac aac ctc cag ggc agc aac acc tat gcc ctg gag aac act atg atc       1584
Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile           
        515                 520                 525                       

ttc aac agc cag ccg gcg aac ccg ggc acc acc gcc acg tac ctc gag       1632
Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu           
    530                 535                 540                           

ggc aac atg ctc atc acc agc gag agc gag acg cag ccg gtg aac cgc       1680
Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg           
545                 550                 555                 560           

gtg gcg tac aac gtc ggc ggg cag atg gcc acc aac aac cag agc tcc       1728
Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser           
                565                 570                 575               

acc act gcc ccc gcg acc ggc acg tac aac ctc cag gaa atc gtg ccc       1776
Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro           
            580                 585                 590                   

ggc agc gtg tgg atg gag agg gac gtg tac ctc caa gga ccc atc tgg       1824
Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp           
        595                 600                 605                       

gcc aag atc cca gag acg ggg gcg cac ttt cac ccc tct ccg gcc atg       1872
Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met           
    610                 615                 620                           

ggc gga ttc gga ctc aaa cac cca ccg ccc atg atg ctc atc aag aac       1920
Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn           
625                 630                 635                 640           

acg cct gtg ccc gga aat atc acc agc ttc tcg gac gtg ccc gtc agc       1968
Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser           
                645                 650                 655               

agc ttc atc acc cag tac agc acc ggg cag gtc acc gtg gag atg gag       2016
Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu           
            660                 665                 670                   

tgg gag ctc aag aag gaa aac tcc aag agg tgg aac cca gag atc cag       2064
Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln           
        675                 680                 685                       

tac aca aac aac tac aac gac ccc cag ttt gtg gac ttt gcc ccg gac       2112
Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp           
    690                 695                 700                           

agc acc ggg gaa tac aga acc acc aga cct atc gga acc cga tac ctt       2160
Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu           
705                 710                 715                 720           

acc cga ccc ctt                                                       2172
Thr Arg Pro Leu                                                           
                                                                          


<210>  29
<211>  724
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  29

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  30
<211>  2211
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAVhu68 VP1 capsid


<220>
<221>  CDS
<222>  (1)..(2211)

<400>  30
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc agt         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gaa ggc att cgc gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro           
            20                  25                  30                    

aag gca aat caa caa cat caa gac aac gct cgg ggt ctt gtg ctt ccg        144
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggt tac aaa tac ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg        192
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gaa gca gac gcg gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aag gcc gga gac aac ccg tac ctc aag tac aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttc cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro           
        115                 120                 125                       

ctt ggt ctg gtt gag gaa gcg gct aag acg gct cct gga aag aag agg        432
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

cct gta gag cag tct cct cag gaa ccg gac tcc tcc gtg ggt att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly           
145                 150                 155                 160           

aaa tcg ggt gca cag ccc gct aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac aca gag tca gtc ccc gac cct caa cca atc gga gaa cct ccc        576
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro           
            180                 185                 190                   

gca gcc ccc tca ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc        624
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca gtg gca gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc        672
Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser           
    210                 215                 220                           

tcg gga aat tgg cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aat cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc aac agc aca tct gga gga tct tca aat gac aac        816
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn           
            260                 265                 270                   

gcc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac aga        864
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg           
        275                 280                 285                       

ttc cac tgc cac ttc tca cca cgt gac tgg caa aga ctc atc aac aac        912
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn           
    290                 295                 300                           

aac tgg gga ttc cgg cct aag cga ctc aac ttc aag ctc ttc aac att        960
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile           
305                 310                 315                 320           

cag gtc aaa gag gtt acg gac aac aat gga gtc aag acc atc gct aat       1008
Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn           
                325                 330                 335               

aac ctt acc agc acg gtc cag gtc ttc acg gac tca gac tat cag ctc       1056
Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu           
            340                 345                 350                   

ccg tac gtg ctc ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca       1104
Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro           
        355                 360                 365                       

gcg gac gtt ttc atg att cct cag tac ggg tat cta acg ctt aat gat       1152
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp           
    370                 375                 380                           

gga agc caa gcc gtg ggt cgt tcg tcc ttt tac tgc ctg gaa tat ttc       1200
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe           
385                 390                 395                 400           

ccg tcg caa atg cta aga acg ggt aac aac ttc cag ttc agc tac gag       1248
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu           
                405                 410                 415               

ttt gag aac gta cct ttc cat agc agc tat gct cac agc caa agc ctg       1296
Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu           
            420                 425                 430                   

gac cga ctc atg aat cca ctc atc gac caa tac ttg tac tat ctc tca       1344
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser           
        435                 440                 445                       

aag act att aac ggt tct gga cag aat caa caa acg cta aaa ttc agt       1392
Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser           
    450                 455                 460                           

gtg gcc gga ccc agc aac atg gct gtc cag gga aga aac tac ata cct       1440
Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro           
465                 470                 475                 480           

gga ccc agc tac cga caa caa cgt gtc tca acc act gtg act caa aac       1488
Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn           
                485                 490                 495               

aac aac agc gaa ttt gct tgg cct gga gct tct tct tgg gct ctc aat       1536
Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn           
            500                 505                 510                   

gga cgt aat agc ttg atg aat cct gga cct gct atg gcc agc cac aaa       1584
Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys           
        515                 520                 525                       

gaa gga gag gac cgt ttc ttt cct ttg tct gga tct tta att ttt ggc       1632
Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly           
    530                 535                 540                           

aaa caa gga act gga aga gac aac gtg gat gcg gac aaa gtc atg ata       1680
Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile           
545                 550                 555                 560           

acc aac gaa gaa gaa att aaa act acc aac cca gta gca acg gag tcc       1728
Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser           
                565                 570                 575               

tat gga caa gtg gcc aca aac cac cag agt gcc caa gca cag gcg cag       1776
Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln           
            580                 585                 590                   

acc ggc tgg gtt caa aac caa gga ata ctt ccg ggt atg gtt tgg cag       1824
Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gat gtg tac ctg caa gga ccc att tgg gcc aaa att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gac ggc aac ttt cac cct tct ccg ctg atg gga ggg ttt gga atg       1920
Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac aca cct gta cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

gat cct cca acg gct ttc aac aag gac aag ctg aac tct ttc atc acc       2016
Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr           
            660                 665                 670                   

cag tat tct act ggc caa gtc agc gtg gag att gag tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aag gaa aac agc aag cgc tgg aac ccg gag atc cag tac act tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tat tac aag tct aat aat gtt gaa ttt gct gtt aat act gaa ggt gtt       2160
Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val           
705                 710                 715                 720           

tat tct gaa ccc cgc ccc att ggc acc aga tac ctg act cgt aat ctg       2208
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu           
                725                 730                 735               

taa                                                                   2211


<210>  31
<211>  736
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  31

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miRNA target sequence

<400>  32
agtgaattct accagtgcca ta                                                22


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miRNA target sequence

<400>  33
agcaaaaatg tgctagtgcc aaa                                               23


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miRNA target sequence

<400>  34
agtgtgagtt ctaccattgc caaa                                              24


<210>  35
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miRNA target sequence

<400>  35
agggattcct gggaaaactg gac                                               23


