                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
      EMORY UNIVERSITY
 
<120> METHODS AND COMPOSITIONS RELATING TO THE TREATMENT OF GVHD

<130> 701039-094490WOPT

<140>
<141>

<150> 62/956,707
<151> 2020-01-03

<150> 62/809,010
<151> 2019-02-22

<160> 4     

<170> PatentIn version 3.5

<210> 1
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210> 2
<211> 217
<212> PRT
<213> Homo sapiens

<400> 2
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
            20                  25                  30          


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
        35                  40                  45              


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
    50                  55                  60                  


Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn 
65                  70                  75                  80  


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
                85                  90                  95      


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
            100                 105                 110         


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
        115                 120                 125             


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
    130                 135                 140                 


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
145                 150                 155                 160 


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
                165                 170                 175     


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
            180                 185                 190         


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
        195                 200                 205             


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
    210                 215         


<210> 3
<211> 521
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Gly Arg Arg Phe His Leu Ser Thr Thr Asp Arg Val Ile Lys 
1               5                   10                  15      


Ala Val Pro Phe Pro Pro Thr Gln Arg Leu Thr Phe Lys Glu Val Phe 
            20                  25                  30          


Glu Asn Gly Lys Pro Lys Val Asp Val Leu Lys Asn His Leu Val Lys 
        35                  40                  45              


Glu Gly Arg Leu Glu Glu Glu Val Ala Leu Lys Ile Ile Asn Asp Gly 
    50                  55                  60                  


Ala Ala Ile Leu Arg Gln Glu Lys Thr Met Ile Glu Val Asp Ala Pro 
65                  70                  75                  80  


Ile Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe Asp Leu Met Lys 
                85                  90                  95      


Leu Phe Glu Val Gly Gly Ser Pro Ser Asn Thr Arg Tyr Leu Phe Leu 
            100                 105                 110         


Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys Val Leu Tyr 
        115                 120                 125             


Leu Trp Ser Leu Lys Ile Asn His Pro Lys Thr Leu Phe Leu Leu Arg 
    130                 135                 140                 


Gly Asn His Glu Cys Arg His Leu Thr Asp Tyr Phe Thr Phe Lys Gln 
145                 150                 155                 160 


Glu Cys Arg Ile Lys Tyr Ser Glu Gln Val Tyr Asp Ala Cys Met Glu 
                165                 170                 175     


Thr Phe Asp Cys Leu Pro Leu Ala Ala Leu Leu Asn Gln Gln Phe Leu 
            180                 185                 190         


Cys Val His Gly Gly Met Ser Pro Glu Ile Thr Ser Leu Asp Asp Ile 
        195                 200                 205             


Arg Lys Leu Asp Arg Phe Thr Glu Pro Pro Ala Phe Gly Pro Val Cys 
    210                 215                 220                 


Asp Leu Leu Trp Ser Asp Pro Ser Glu Asp Tyr Gly Asn Glu Lys Thr 
225                 230                 235                 240 


Leu Glu His Tyr Thr His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr 
                245                 250                 255     


Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln Asn Asn Asn Leu Leu Ser 
            260                 265                 270         


Ile Ile Arg Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg 
        275                 280                 285             


Lys Ser Gln Ala Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala 
    290                 295                 300                 


Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr 
305                 310                 315                 320 


Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro 
                325                 330                 335     


Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe 
            340                 345                 350         


Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val Leu Asn Ile Cys 
        355                 360                 365             


Ser Asp Asp Glu Leu Ile Ser Asp Asp Glu Ala Glu Asp His Tyr Ile 
    370                 375                 380                 


Pro Ser Tyr Gln Lys Gly Ser Thr Thr Val Arg Lys Glu Ile Ile Arg 
385                 390                 395                 400 


Asn Lys Ile Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser Ile Leu 
                405                 410                 415     


Arg Gln Glu Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr Pro Thr 
            420                 425                 430         


Gly Thr Leu Pro Leu Gly Val Leu Ser Gly Gly Lys Gln Thr Ile Glu 
        435                 440                 445             


Thr Ala Thr Val Glu Ala Val Glu Ala Arg Glu Ala Ile Arg Gly Phe 
    450                 455                 460                 


Ser Leu Gln His Lys Ile Arg Ser Phe Glu Glu Ala Arg Gly Leu Asp 
465                 470                 475                 480 


Arg Ile Asn Glu Arg Met Pro Pro Arg Lys Asp Ser Ile His Ala Gly 
                485                 490                 495     


Gly Pro Met Lys Ser Val Thr Ser Ala His Ser His Ala Ala His Arg 
            500                 505                 510         


Ser Asp Gln Gly Lys Lys Ala His Ser 
        515                 520     


<210> 4
<211> 187
<212> PRT
<213> Homo sapiens

<400> 4
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


