                         SEQUENCE LISTING

<110>  Rutgers, The State University of New Jersey
       Liu, Dongfang
 
<120>  EXPANSION OF NATURAL KILLER AND CHIMERIC ANTIGEN 
       RECEPTOR-MODIFIED CELLS

<130>  7213-101957-02

<150>  US 62/808,031
<151>  2019-02-20

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of the extracellular domain from 
       interleukin (IL)-21

<400>  1
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgcgtc       60

gaccaaggtc aagatcgcca catgattaga atgcgtcaac ttatagatat tgttgatcag      120

ctgaaaaatt atgtgaatga cttggtccct gaatttctgc cagctccaga agatgtagag      180

acaaactgtg agtggtcagc tttttcctgc tttcagaagg cccaactaaa gtcagcaaat      240

acaggaaaca atgaaaggat aatcaatgta tcaattaaaa agctgaagag gaaaccacct      300

tccacaaatg cagggagaag acagaaacac agactaacat gcccttcatg tgattcttat      360

gagaaaaaac cacccaaaga attcctagaa agattcaaat cacttctcca aaagatgatt      420

catcagcatc tgtcctctag aacacacgga agtgaagatt cc                         462


<210>  2
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of the extracellular domain from 
       IL-21

<400>  2

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Val Asp Gln Gly Gln Asp Arg His Met Ile Arg Met Arg 
            20                  25                  30          


Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu 
        35                  40                  45              


Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu 
    50                  55                  60                  


Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn 
65                  70                  75                  80  


Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys 
                85                  90                  95      


Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu 
            100                 105                 110         


Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe 
        115                 120                 125             


Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu 
    130                 135                 140                 


Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
145                 150                 


<210>  3
<211>  1881
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of a construct for transducing 
       cells with membrane-bound (m)IL-21

<400>  3
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgcgtc       60

gaccaaggtc aagatcgcca catgattaga atgcgtcaac ttatagatat tgttgatcag      120

ctgaaaaatt atgtgaatga cttggtccct gaatttctgc cagctccaga agatgtagag      180

acaaactgtg agtggtcagc tttttcctgc tttcagaagg cccaactaaa gtcagcaaat      240

acaggaaaca atgaaaggat aatcaatgta tcaattaaaa agctgaagag gaaaccacct      300

tccacaaatg cagggagaag acagaaacac agactaacat gcccttcatg tgattcttat      360

gagaaaaaac cacccaaaga attcctagaa agattcaaat cacttctcca aaagatgatt      420

catcagcatc tgtcctctag aacacacgga agtgaagatt ccctgcggcc gccgtacgtc      480

accgtctctt cacaggatcc cgccgagccc aaatctcctg acaaaactca cacatgccca      540

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      600

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      660

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      720

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc      780

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      840

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag      900

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc      960

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcaaccg     1020

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1080

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1140

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1200

aaagatccca aattttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg     1260

ctagtaacag tggcctttat tattttttgg gtgaggagta agaggagcag gctcctgcac     1320

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1380

tatgccccac cacgcgactt cgcagcctat cgctccaaac ggggcagaaa gaaactcctg     1440

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1500

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1560

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1620

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1680

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1740

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1800

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1860

caggccctgc cccctcgcta a                                               1881


<210>  4
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-15Ralpha

<400>  4
ctgggcagcg ctcgcccggg gagtccagcg gtgtcctgtg gagctgccgc catggccccg       60

cggcgggcgc gcggctgccg gaccctcggt ctcccggcgc tgctactgct gctgctgctc      120

cggccgccgg cgacgcgggg catcacgtgc cctcccccca tgtccgtgga acacgcagac      180

atctgggtca agagctacag cttgtactcc agggagcggt acatttgtaa ctctggtttc      240

aagcgtaaag ccggcacgtc cagcctgacg gagtgcgtgt tgaacaaggc cacgaatgtc      300

gcccactgga caacccccag tctcaaatgc attagagacc ctgccctggt tcaccaaagg      360

ccagcgccac cctccacagt aacgacggca ggggtgaccc cacagccaga gagcctctcc      420

ccttctggaa aagagcccgc agcttcatct cccagctcaa acaacacagc ggccacaaca      480

gcagctattg tcccgggctc ccagctgatg ccttcaaaat caccttccac aggaaccaca      540

gagataagca gtcatgagtc ctcccacggc accccctctc agacaacagc caagaactgg      600

gaactcacag catccgcctc ccaccagccg ccaggtgtgt atccacaggg ccacagcgac      660

accactgtgg ctatctccac gtccactgtc ctgctgtgtg ggctgagcgc tgtgtctctc      720

ctggcatgct acctcaagtc aaggcaaact cccccgctgg ccagcgttga aatggaagcc      780

atggaggctc tgccggtgac ttgggggacc agcagcagag atgaagactt ggaaaactgc      840

tctcaccacc tatgaaactc ggggaaacca gcccagctaa gtccggagtg aaggagcctc      900

tctgctttag ctaaagacga ctgagaagag gtgcaaggaa gcgggctcca ggagcaagct      960

caccaggcct ctcagaagtc ccagcaggat ctcacggact gccgggtcgg cgcctcctgc     1020

gcgagggagc aggttctccg cattcccatg ggcaccacct gcctgcctgt cgtgccttgg     1080

acccagggcc cagcttccca ggagagacca aaggcttctg agcaggattt ttatttcatt     1140

acagtgtgag ctgcctggaa tacatgtggt aatgaaataa aaaccctgcc ccgaatcttc     1200

cgtccctcat cctaactttc agttcacaga gaaaagtgac atacccaaag ctctctgtca     1260

attacaaggc ttctcctggc gtgggagacg tctacaggga agacaccagc gtttgggctt     1320

ctaaccaccc tgtctccagc tgctctgcac acatggacag ggacctggga aaggtgggag     1380

agatgctgag cccagcgaat cctctccatt gaaggattca ggaagaagaa aactcaactc     1440

agtgccattt tacgaatata tgcgtttata tttatacttc cttgtctatt atatctatac     1500

attatatatt atttgtattt tgacattgta ccttgtataa acaaaataaa acatctattt     1560

tcaata                                                                1566


<210>  5
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of IL-15Ralpha.

<400>  5

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  6
<211>  2333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-15

<400>  6
gttgggactc cgggtggcag gcgcccgggg gaatcccagc tgactcgctc actgccttcg       60

aagtccggcg ccccccggga gggaactggg tggccgcacc ctcccggctg cggtggctgt      120

cgccccccac cctgcagcca ggactcgatg gagaatccat tccaatatat ggccatgtgg      180

ctctttggag caatgttcca tcatgttcca tgctgctgac gtcacatgga gcacagaaat      240

caatgttagc agatagccag cccatacaag atcgttttca actagtggcc ccactgtgtc      300

cggaattgat gggttcttgg tctcactgac ttcaagaatg aagccgcgga ccctcgcggt      360

gagtgttaca gctcttaagg tggcgcatct ggagtttgtt ccttctgatg ttcggatgtg      420

ttcggagttt cttccttctg gtgggttcgt ggtctcgctg gctcaggagt gaagctacag      480

accttcgcgg aggcattgtg gatggatggc tgctggaaac cccttgccat agccagctct      540

tcttcaatac ttaaggattt accgtggctt tgagtaatga gaatttcgaa accacatttg      600

agaagtattt ccatccagtg ctacttgtgt ttacttctaa acagtcattt tctaactgaa      660

gctggcattc atgtcttcat tttgggatgc agctaatata cccagttggc ccaaagcacc      720

taacctatag ttatataatc tgactctcag ttcagtttta ctctactaat gccttcatgg      780

tattgggaac catagatttg tgcagctgtt tcagtgcagg gcttcctaaa acagaagcca      840

actgggtgaa tgtaataagt gatttgaaaa aaattgaaga tcttattcaa tctatgcata      900

ttgatgctac tttatatacg gaaagtgatg ttcaccccag ttgcaaagta acagcaatga      960

agtgctttct cttggagtta caagttattt cacttgagtc cggagatgca agtattcatg     1020

atacagtaga aaatctgatc atcctagcaa acaacagttt gtcttctaat gggaatgtaa     1080

cagaatctgg atgcaaagaa tgtgaggaac tggaggaaaa aaatattaaa gaatttttgc     1140

agagttttgt acatattgtc caaatgttca tcaacacttc ttgattgcaa ttgattcttt     1200

ttaaagtgtt tctgttatta acaaacatca ctctgctgct tagacataac aaaacactcg     1260

gcatttcaaa tgtgctgtca aaacaagttt ttctgtcaag aagatgatca gaccttggat     1320

cagatgaact cttagaaatg aaggcagaaa aatgtcattg agtaatatag tgactatgaa     1380

cttctctcag acttacttta ctcatttttt taatttatta ttgaaattgt acatatttgt     1440

ggaataatgt aaaatgttga ataaaaatat gtacaagtgt tgttttttaa gttgcactga     1500

tattttacct cttattgcaa aatagcattt gtttaagggt gatagtcaaa ttatgtattg     1560

gtggggctgg gtaccaatgc tgcaggtcaa cagctatgct ggtaggctcc tgccagtgtg     1620

gaaccactga ctactggctc tcattgactt ccttactaag catagcaaac agaggaagaa     1680

tttgttatca gtaagaaaaa gaagaactat atgtgaatcc tcttctttat actgtaattt     1740

agttattgat gtataaagca actgttatga aataaagaaa ttgcaataac tggcatataa     1800

tgtccatcag taaatcttgg tggtggtggc aataataaac ttctactgat aggtagaatg     1860

gtgtgcaagc ttgtccaatc acggattgca ggccacatgc ggcccaggac aactttgaat     1920

gtggcccaac acaaattcat aaactttcat acatctcgtt tttagctcat cagctatcat     1980

tagcggtagt gtatttaaag tgtggcccaa gacaattctt cttattccaa tgtggcccag     2040

ggaaatcaaa agattggatg cccctggtat agaaaactaa tagtgacagt gttcatattt     2100

catgctttcc caaatacagg tattttattt tcacattctt tttgccatgt ttatataata     2160

ataaagaaaa accctgttga tttgttggag ccattgttat ctgacagaaa ataattgttt     2220

atattttttg cactacactg tctaaaatta gcaagctctc ttctaatgga actgtaagaa     2280

agatgaaata tttttgtttt attataaatt tatttcacct taaaaaaaaa aaa            2333


<210>  7
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of IL-15

<400>  7

Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
1               5                   10                  15      


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


<210>  8
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-2

<400>  8
agttccctat cactctcttt aatcactact cacagtaacc tcaactcctg ccacaatgta       60

caggatgcaa ctcctgtctt gcattgcact aagtcttgca cttgtcacaa acagtgcacc      120

tacttcaagt tctacaaaga aaacacagct acaactggag catttactgc tggatttaca      180

gatgattttg aatggaatta ataattacaa gaatcccaaa ctcaccagga tgctcacatt      240

taagttttac atgcccaaga aggccacaga actgaaacat cttcagtgtc tagaagaaga      300

actcaaacct ctggaggaag tgctaaattt agctcaaagc aaaaactttc acttaagacc      360

cagggactta atcagcaata tcaacgtaat agttctggaa ctaaagggat ctgaaacaac      420

attcatgtgt gaatatgctg atgagacagc aaccattgta gaatttctga acagatggat      480

taccttttgt caaagcatca tctcaacact gacttgataa ttaagtgctt cccacttaaa      540

acatatcagg ccttctattt atttaaatat ttaaatttta tatttattgt tgaatgtatg      600

gtttgctacc tattgtaact attattctta atcttaaaac tataaatatg gatcttttat      660

gattcttttt gtaagcccta ggggctctaa aatggtttca cttatttatc ccaaaatatt      720

tattattatg ttgaatgtta aatatagtat ctatgtagat tggttagtaa aactatttaa      780

taaatttgat aaatataaaa aaaaaaaaaa aaaaaaaaaa aa                         822


<210>  9
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of IL-2

<400>  9

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  10
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-27

<400>  10
gaccaaagag gctgggcccc gccatgggcc agacggcagg cgaccttggc tggcggctca       60

gcctgttgct gcttcccttg ctcctggttc aagctggtgt ctggggattc ccaaggcccc      120

cagggaggcc ccagctgagc ctgcaggagc tgcggaggga gttcacagtc agcctgcatc      180

tcgccaggaa gctgctctcc gaggttcggg gccaggccca ccgctttgcg gaatctcacc      240

tgccaggagt gaacctgtac ctcctgcccc tgggagagca gctccctgat gtttccctga      300

ccttccaggc ctggcgccgc ctctctgacc cggagcgtct ctgcttcatc tccaccacgc      360

ttcagccctt ccatgccctg ctgggagggc tggggaccca gggccgctgg accaacatgg      420

agaggatgca gctgtgggcc atgaggctgg acctccgcga tctgcagcgg cacctccgct      480

tccaggtgct ggctgcagga ttcaacctcc cggaggagga ggaggaggaa gaggaggagg      540

aggaggagga gaggaagggg ctgctcccag gggcactggg cagcgcctta cagggcccgg      600

cccaggtgtc ctggccccag ctcctctcca cctaccgcct gctgcactcc ttggagctcg      660

tcttatctcg ggccgtgcgg gagttgctgc tgctgtccaa ggctgggcac tcagtctggc      720

ccttggggtt cccaacattg agcccccagc cctgatcggt ggcttcttag ccccctgccc      780

cccacccttt agaactttag gactggagtc ttggcatcag ggcagccttc gcatcatcag      840

ccttggacaa gggagggctc ttccagcccc ctgccccagg ctctacccag taactgaaag      900

cccctctggt cctcgccagc tatttatttc ttggatattt atttattgtt tagggagatg      960

atggtttatt tattgtcttg gggcccgatg gtcctcctcg ggccaagccc ccatgctggg     1020

tgcccaataa agcactctca tcca                                            1044


<210>  11
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of IL-27

<400>  11

Met Gly Gln Thr Ala Gly Asp Leu Gly Trp Arg Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Leu Val Gln Ala Gly Val Trp Gly Phe Pro Arg Pro 
            20                  25                  30          


Pro Gly Arg Pro Gln Leu Ser Leu Gln Glu Leu Arg Arg Glu Phe Thr 
        35                  40                  45              


Val Ser Leu His Leu Ala Arg Lys Leu Leu Ser Glu Val Arg Gly Gln 
    50                  55                  60                  


Ala His Arg Phe Ala Glu Ser His Leu Pro Gly Val Asn Leu Tyr Leu 
65                  70                  75                  80  


Leu Pro Leu Gly Glu Gln Leu Pro Asp Val Ser Leu Thr Phe Gln Ala 
                85                  90                  95      


Trp Arg Arg Leu Ser Asp Pro Glu Arg Leu Cys Phe Ile Ser Thr Thr 
            100                 105                 110         


Leu Gln Pro Phe His Ala Leu Leu Gly Gly Leu Gly Thr Gln Gly Arg 
        115                 120                 125             


Trp Thr Asn Met Glu Arg Met Gln Leu Trp Ala Met Arg Leu Asp Leu 
    130                 135                 140                 


Arg Asp Leu Gln Arg His Leu Arg Phe Gln Val Leu Ala Ala Gly Phe 
145                 150                 155                 160 


Asn Leu Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                165                 170                 175     


Arg Lys Gly Leu Leu Pro Gly Ala Leu Gly Ser Ala Leu Gln Gly Pro 
            180                 185                 190         


Ala Gln Val Ser Trp Pro Gln Leu Leu Ser Thr Tyr Arg Leu Leu His 
        195                 200                 205             


Ser Leu Glu Leu Val Leu Ser Arg Ala Val Arg Glu Leu Leu Leu Leu 
    210                 215                 220                 


Ser Lys Ala Gly His Ser Val Trp Pro Leu Gly Phe Pro Thr Leu Ser 
225                 230                 235                 240 


Pro Gln Pro 
            


<210>  12
<211>  2347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-12B

<400>  12
ctgtttcagg gccattggac tctccgtcct gcccagagca agatgtgtca ccagcagttg       60

gtcatctctt ggttttccct ggtttttctg gcatctcccc tcgtggccat atgggaactg      120

aagaaagatg tttatgtcgt agaattggat tggtatccgg atgcccctgg agaaatggtg      180

gtcctcacct gtgacacccc tgaagaagat ggtatcacct ggaccttgga ccagagcagt      240

gaggtcttag gctctggcaa aaccctgacc atccaagtca aagagtttgg agatgctggc      300

cagtacacct gtcacaaagg aggcgaggtt ctaagccatt cgctcctgct gcttcacaaa      360

aaggaagatg gaatttggtc cactgatatt ttaaaggacc agaaagaacc caaaaataag      420

acctttctaa gatgcgaggc caagaattat tctggacgtt tcacctgctg gtggctgacg      480

acaatcagta ctgatttgac attcagtgtc aaaagcagca gaggctcttc tgacccccaa      540

ggggtgacgt gcggagctgc tacactctct gcagagagag tcagagggga caacaaggag      600

tatgagtact cagtggagtg ccaggaggac agtgcctgcc cagctgctga ggagagtctg      660

cccattgagg tcatggtgga tgccgttcac aagctcaagt atgaaaacta caccagcagc      720

ttcttcatca gggacatcat caaacctgac ccacccaaga acttgcagct gaagccatta      780

aagaattctc ggcaggtgga ggtcagctgg gagtaccctg acacctggag tactccacat      840

tcctacttct ccctgacatt ctgcgttcag gtccagggca agagcaagag agaaaagaaa      900

gatagagtct tcacggacaa gacctcagcc acggtcatct gccgcaaaaa tgccagcatt      960

agcgtgcggg cccaggaccg ctactatagc tcatcttgga gcgaatgggc atctgtgccc     1020

tgcagttagg ttctgatcca ggatgaaaat ttggaggaaa agtggaagat attaagcaaa     1080

atgtttaaag acacaacgga atagacccaa aaagataatt tctatctgat ttgctttaaa     1140

acgttttttt aggatcacaa tgatatcttt gctgtatttg tatagttaga tgctaaatgc     1200

tcattgaaac aatcagctaa tttatgtata gattttccag ctctcaagtt gccatgggcc     1260

ttcatgctat ttaaatattt aagtaattta tgtatttatt agtatattac tgttatttaa     1320

cgtttgtctg ccaggatgta tggaatgttt catactctta tgacctgatc catcaggatc     1380

agtccctatt atgcaaaatg tgaatttaat tttatttgta ctgacaactt ttcaagcaag     1440

gctgcaagta catcagtttt atgacaatca ggaagaatgc agtgttctga taccagtgcc     1500

atcatacact tgtgatggat gggaacgcaa gagatactta catggaaacc tgacaatgca     1560

aacctgttga gaagatccag gagaacaaga tgctagttcc catgtctgtg aagacttcct     1620

ggagatggtg ttgataaagc aatttagggc cacttacact tctaagcaag tttaatcttt     1680

ggatgcctga attttaaaag ggctagaaaa aaatgattga ccagcctggg aaacataaca     1740

agaccccgtc tctacaaaaa aaatttaaaa ttagccaggc gtggtggctc atgcttgtgg     1800

tcccagctgt tcaggaggat gaggcaggag gatctcttga gcccaggagg tcaaggctat     1860

ggtgagccgt gattgtgcca ctgcatacca gcctaggtga cagaatgaga ccctgtctca     1920

aaaaaaaaaa tgattgaaat taaaattcag ctttagcttc catggcagtc ctcaccccca     1980

cctctctaaa agacacagga ggatgacaca gaaacaccgt aagtgtctgg aaggcaaaaa     2040

gatcttaaga ttcaagagag aggacaagta gttatggcta aggacatgaa attgtcagaa     2100

tggcaggtgg cttcttaaca gccctgtgag aagcagacag atgcaaagaa aatctggaat     2160

ccctttctca ttagcatgaa tgaacctgat acacaattat gaccagaaaa tatggctcca     2220

tgaaggtgct acttttaagt aatgtatgtg cgctctgtaa agtgattaca tttgtttcct     2280

gtttgtttat ttatttattt atttttgcat tctgaggctg aactaataaa aactcttctt     2340

tgtaatc                                                               2347


<210>  13
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of IL-12B

<400>  13

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  14
<211>  823
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-12 p35

<400>  14
agaaagcaag agaccagagt cccgggaaag tcctgccgcg cctcgggaca attataaaaa       60

tgtggccccc tgggtcagcc tcccagccac cgccctcacc tgccgcggcc acaggtctgc      120

atccagcggc tcgccctgtg tccctgcagt gccggctcag catgtgtcca gcgcgcagcc      180

tcctccttgt ggctaccctg gtcctcctgg accacctcag tttggccaga aacctccccg      240

tggccactcc agacccagga atgttcccat gccttcacca ctcccaaaac ctgctgaggg      300

ccgtcagcaa catgctccag aaggccagac aaactctaga attttaccct tgcacttctg      360

aagagattga tcatgaagat atcacaaaag ataaaaccag cacagtggag gcctgtttac      420

cattggaatt aaccaagaat gagagttgcc taaattccag agagacctct ttcataacta      480

atgggagttg cctggcctcc agaaagacct cttttatgat ggccctgtgc cttagtagta      540

tttatgaaga cttgaagatg taccaggtgg agttcaagac catgaatgca aagcttctga      600

tggatcctaa gaggcagatc tttctagatc aaaacatgct ggcagttatt gatgagctga      660

tgcaggccct gaatttcaac agtgagactg tgccacaaaa atcctccctt gaagaaccgg      720

atttttataa aactaaaatc aagctctgca tacttcttca tgctttcaga attcgggcag      780

tgactattga tagagtgatg agctatctga atgcttccta aaa                        823


<210>  15
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of IL-12 p35

<400>  15

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  16
<211>  1007
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-12 p40

<400>  16
agcaagatgt gtcaccagca gttggtcatc tcttggtttt ccctggtttt tctggcatct       60

cccctcgtgg ccatatggga actgaagaaa gatgtttatg tcgtagaatt ggattggtat      120

ccggatgccc ctggagaaat ggtggtcctc acctgtgaca cccctgaaga agatggtatc      180

acctggacct tggaccagag cagtgaggtc ttaggctctg gcaaaaccct gaccatccaa      240

gtcaaagagt ttggagatgc tggccagtac acctgtcaca aaggaggcga ggttctaagc      300

cattcgctcc tgctgcttca caaaaaggaa gatggaattt ggtccactga tattttaaag      360

gaccagaaag aacccaaaaa taagaccttt ctaagatgcg aggccaagaa ttattctgga      420

cgtttcacct gctggtggct gacgacaatc agtactgatt tgacattcag tgtcaaaagc      480

agcagaggct cttctgaccc ccaaggggtg acgtgcggag ctgctacact ctctgcagag      540

agagtcagag gggacaacaa ggagtatgag tactcagtgg agtgccagga ggacagtgcc      600

tgcccagctg ctgaggagag tctgcccatt gaggtcatgg tggatgccgt tcacaagctc      660

aagtatgaaa actacaccag cagcttcttc atcagggaca tcatcaaacc tgacccaccc      720

aagaacttgc agctgaagcc attaaagaat tctcggcagg tggaggtcag ctgggagtac      780

cctgacacct ggagtactcc acattcctac ttctccctga cattctgcgt tcaggtccag      840

ggcaagagca agagagaaaa gaaagataga gtcttcacgg acaagacctc agccacggtc      900

atctgccgca aaaatgccag cattagcgtg cgggcccagg accgctacta tagctcatct      960

tggagcgaat gggcatctgt gccctgcagt taggttctga tccagga                   1007


<210>  17
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of IL-12 p40.

<400>  17

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  18
<211>  1151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-18

<400>  18
attctctccc cagcttgctg agccctttgc tcccctggcg actgcctgga cagtcagcaa       60

ggaattgtct cccagtgcat tttgccctcc tggctgccaa ctctggctgc taaagcggct      120

gccacctgct gcagtctaca cagcttcggg aagaggaaag gaacctcaga ccttccagat      180

cgcttcctct cgcaacaaac tatttgtcgc aggaataaag atggctgctg aaccagtaga      240

agacaattgc atcaactttg tggcaatgaa atttattgac aatacgcttt actttataga      300

aaacctggaa tcagattact ttggcaagct tgaatctaaa ttatcagtca taagaaattt      360

gaatgaccaa gttctcttca ttgaccaagg aaatcggcct ctatttgaag atatgactga      420

ttctgactgt agagataatg caccccggac catatttatt ataagtatgt ataaagatag      480

ccagcctaga ggtatggctg taactatctc tgtgaagtgt gagaaaattt caactctctc      540

ctgtgagaac aaaattattt cctttaagga aatgaatcct cctgataaca tcaaggatac      600

aaaaagtgac atcatattct ttcagagaag tgtcccagga catgataata agatgcaatt      660

tgaatcttca tcatacgaag gatactttct agcttgtgaa aaagagagag acctttttaa      720

actcattttg aaaaaagagg atgaattggg ggatagatct ataatgttca ctgttcaaaa      780

cgaagactag ctattaaaat ttcatgccgg gcgcagtggc tcacgcctgt aatcccagcc      840

ctttgggagg ctgaggcggg cagatcacca gaggtcaggt gttcaagacc agcctgacca      900

acatggtgaa acctcatctc tactaaaaat acaaaaaatt agctgagtgt agtgacgcat      960

gccctcaatc ccagctactc aagaggctga ggcaggagaa tcacttgcac tccggaggta     1020

gaggttgtgg tgagccgaga ttgcaccatt gcgctctagc ctgggcaaca acagcaaaac     1080

tccatctcaa aaaataaaat aaataaataa acaaataaaa aattcataat gtgaaaaaaa     1140

aaaaaaaaaa a                                                          1151


<210>  19
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of IL-18

<400>  19

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Glu Asn Leu Glu Ser Asp 
            20                  25                  30          


Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
        35                  40                  45              


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
    50                  55                  60                  


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
65                  70                  75                  80  


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
                85                  90                  95      


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
            100                 105                 110         


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
        115                 120                 125             


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
    130                 135                 140                 


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
145                 150                 155                 160 


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
                165                 170                 175     


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
            180                 185                 


<210>  20
<211>  1115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-18

<400>  20
cctttgctcc cctggcgact gcctggacag tcagcaagga attgtctccc agtgcatttt       60

gccctcctgg ctgccaactc tggctgctaa agcggctgcc acctgctgca gtctacacag      120

cttcgggaag aggaaaggaa cctcagacct tccagatcgc ttcctctcgc aacaaactat      180

ttgtcgcagg aataaagatg gctgctgaac cagtagaaga caattgcatc aactttgtgg      240

caatgaaatt tattgacaat acgctttact ttatagctga agatgatgaa aacctggaat      300

cagattactt tggcaagctt gaatctaaat tatcagtcat aagaaatttg aatgaccaag      360

ttctcttcat tgaccaagga aatcggcctc tatttgaaga tatgactgat tctgactgta      420

gagataatgc accccggacc atatttatta taagtatgta taaagatagc cagcctagag      480

gtatggctgt aactatctct gtgaagtgtg agaaaatttc aactctctcc tgtgagaaca      540

aaattatttc ctttaaggaa atgaatcctc ctgataacat caaggataca aaaagtgaca      600

tcatattctt tcagagaagt gtcccaggac atgataataa gatgcaattt gaatcttcat      660

catacgaagg atactttcta gcttgtgaaa aagagagaga cctttttaaa ctcattttga      720

aaaaagagga tgaattgggg gatagatcta taatgttcac tgttcaaaac gaagactagc      780

tattaaaatt tcatgccggg cgcagtggct cacgcctgta atcccagccc tttgggaggc      840

tgaggcgggc agatcaccag aggtcaggtg ttcaagacca gcctgaccaa catggtgaaa      900

cctcatctct actaaaaata caaaaaatta gctgagtgta gtgacgcatg ccctcaatcc      960

cagctactca agaggctgag gcaggagaat cacttgcact ccggaggtag aggttgtggt     1020

gagccgagat tgcaccattg cgctctagcc tgggcaacaa cagcaaaact ccatctcaaa     1080

aaataaaata aataaataaa caaataaaaa attca                                1115


<210>  21
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of IL-18

<400>  21

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  22
<211>  2612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-33

<400>  22
ctgctgcctt ccaccatcag atgatcctca ccagatgcca gcataatatt cttggatttg       60

cctgcctcta gaagtaatcc caacagaagg ccaaagaagt ttgccccatg tactttatga      120

agctccgctc tggccttatg ataaaaaagg aggcctgtta ctttaggaga gaaaccacca      180

aaaggccttc actgaaaaca ggtagaaagc acaaaagaca tctggtactc gctgcctgtc      240

aacagcagtc tactgtggag tgctttgcct ttggtatatc aggggtccag aaatatacta      300

gagcacttca tgattcaagt atcacaggaa tttcacctat tacagagtat cttgcttctc      360

taagcacata caatgatcaa tccattactt ttgctttgga ggatgaaagt tatgagatat      420

atgttgaaga cttgaaaaaa gatgaaaaga aagataaggt gttactgagt tactatgagt      480

ctcaacaccc ctcaaatgaa tcaggtgacg gtgttgatgg taagatgtta atggtaaccc      540

tgagtcctac aaaagacttc tggttgcatg ccaacaacaa ggaacactct gtggagctcc      600

ataagtgtga aaaaccactg ccagaccagg ccttctttgt ccttcataat atgcactcca      660

actgtgtttc atttgaatgc aagactgatc ctggagtgtt tataggtgta aaggataatc      720

atcttgctct gattaaagta gactcttctg agaatttgtg tactgaaaat atcttgttta      780

agctctctga aacttagttg atggaaacct gtgagtcttg ggttgagtac ccaaatgcta      840

ccactggaga aggaatgaga gataaagaaa gagacaggtg acatctaagg gaaatgaaga      900

gtgcttagca tgtgtggaat gttttccata ttatgtataa aaatattttt tctaatcctc      960

cagttattct tttatttccc tctgtataac tgcatcttca atacaagtat cagtatatta     1020

aatagggtat tggtaaagaa acggtcaaca ttctaaagag atacagtctg acctttactt     1080

ttctctagtt tcagtccaga aagaacttca tatttagagc taaggccact gaggaaagag     1140

ccatagctta agtctctatg tagacaggga tccattttaa agagctactt agagaaataa     1200

ttttccacag ttccaaacga taggctcaaa cactagagct gctagtaaaa agaagaccag     1260

atgcttcaca gaattatcat tttttcaact ggaataaaac accaggtttg tttgtagatg     1320

tcttaggcaa cactcagagc agatctccct tactgtcagg ggatatggaa cttcaaaggc     1380

ccacatggca agccaggtaa cataaatgtg tgaaaaagta aagataacta aaaaatttag     1440

aaaaataaat ccagtatttg taaagtgaat aacttcattt ctaattgttt aatttttaaa     1500

attctgattt ttatatattg agtttaagca aggcattctt acacgaggaa gtgaagtaaa     1560

ttttagttca gacataaaat ttcacttatt aggaatatgt aacatgctaa aacttttttt     1620

tttttaaaga gtactgagtc acaacatgtt ttagagcatc caagtaccat ataatccaac     1680

tatcatggta aggccagaaa tcttctaacc taccagagcc tagatgagac accgaattaa     1740

cattaaaatt tcagtaactg actgtccctc atgtccatgg cctaccatcc cttctgaccc     1800

tggcttccag ggacctatgt cttttaatac tcactgtcac attgggcaaa gttgcttcta     1860

atccttattt cccatgtgca caagtctttt tgtattccag cttcctgata acactgctta     1920

ctgtggaata ttcatttgac atctgtctct tttcatttct tttaactacc atgcccttga     1980

tatatctttt gcacctgctg aacttcattt ctgtatcacc tgacctctgg atgccaaaac     2040

gtttattctg ctttgtctgt tgtagaattt tagataaagc tattaatggc aatatttttt     2100

tgctaaacgt ttttgttttt tactgtcact agggcaataa aatttatact caaccatata     2160

ataacatttt ttaactacta aaggagtagt ttttatttta aagtcttagc aatttctatt     2220

acaacttttc ttagacttaa cacttatgat aaatgactaa catagtaaca gaatctttat     2280

gaaatatgac cttttctgaa aatacatact tttacatttc tactttattg agacctatta     2340

gatgtaagtg ctagtagaat ataagataaa agaggctgag aattaccata caagggtatt     2400

acaactgtaa aacaatttat ctttgtttca ttgttctgtc aataattgtt accaaagaga     2460

taaaaataaa agcagaatgt atatcatccc atctgaaaaa cactaattat tgacatgtgc     2520

atctgtacaa taaacttaaa atgattatta aataatcaaa tatatctact acattgttta     2580

tattattgaa taaagtatat tttccaaatg ta                                   2612


<210>  23
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of IL-33

<400>  23

Met Tyr Phe Met Lys Leu Arg Ser Gly Leu Met Ile Lys Lys Glu Ala 
1               5                   10                  15      


Cys Tyr Phe Arg Arg Glu Thr Thr Lys Arg Pro Ser Leu Lys Thr Gly 
            20                  25                  30          


Arg Lys His Lys Arg His Leu Val Leu Ala Ala Cys Gln Gln Gln Ser 
        35                  40                  45              


Thr Val Glu Cys Phe Ala Phe Gly Ile Ser Gly Val Gln Lys Tyr Thr 
    50                  55                  60                  


Arg Ala Leu His Asp Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu 
65                  70                  75                  80  


Tyr Leu Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala 
                85                  90                  95      


Leu Glu Asp Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp 
            100                 105                 110         


Glu Lys Lys Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro 
        115                 120                 125             


Ser Asn Glu Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met Val Thr 
    130                 135                 140                 


Leu Ser Pro Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys Glu His 
145                 150                 155                 160 


Ser Val Glu Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe 
                165                 170                 175     


Phe Val Leu His Asn Met His Ser Asn Cys Val Ser Phe Glu Cys Lys 
            180                 185                 190         


Thr Asp Pro Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu 
        195                 200                 205             


Ile Lys Val Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe 
    210                 215                 220                 


Lys Leu Ser Glu Thr 
225                 


<210>  24
<211>  2016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of IL-7

<400>  24
acacttgtgg cttccgtgca cacattaaca actcatggtt ctagctccca gtcgccaagc       60

gttgccaagg cgttgagaga tcatctggga agtcttttac ccagaattgc tttgattcag      120

gccagctggt ttttcctgcg gtgattcgga aattcgcgaa ttcctctggt cctcatccag      180

gtgcgcggga agcaggtgcc caggagagag gggataatga agattccatg ctgatgatcc      240

caaagattga acctgcagac caagcgcaaa gtagaaactg aaagtacact gctggcggat      300

cctacggaag ttatggaaaa ggcaaagcgc agagccacgc cgtagtgtgt gccgcccccc      360

ttgggatgga tgaaactgca gtcgcggcgt gggtaagagg aaccagctgc agagatcacc      420

ctgcccaaca cagactcggc aactccgcgg aagaccaggg tcctgggagt gactatgggc      480

ggtgagagct tgctcctgct ccagttgcgg tcatcatgac tacgcccgcc tcccgcagac      540

catgttccat gtttctttta ggtatatctt tggacttcct cccctgatcc ttgttctgtt      600

gccagtagca tcatctgatt gtgatattga aggtaaagat ggcaaacaat atgagagtgt      660

tctaatggtc agcatcgatc aattattgga cagcatgaaa gaaattggta gcaattgcct      720

gaataatgaa tttaactttt ttaaaagaca tatctgtgat gctaataagg aaggtatgtt      780

tttattccgt gctgctcgca agttgaggca atttcttaaa atgaatagca ctggtgattt      840

tgatctccac ttattaaaag tttcagaagg cacaacaata ctgttgaact gcactggcca      900

ggttaaagga agaaaaccag ctgccctggg tgaagcccaa ccaacaaaga gtttggaaga      960

aaataaatct ttaaaggaac agaaaaaact gaatgacttg tgtttcctaa agagactatt     1020

acaagagata aaaacttgtt ggaataaaat tttgatgggc actaaagaac actgaaaaat     1080

atggagtggc aatatagaaa cacgaacttt agctgcatcc tccaagaatc tatctgctta     1140

tgcagttttt cagagtggaa tgcttcctag aagttactga atgcaccatg gtcaaaacgg     1200

attagggcat ttgagaaatg catattgtat tactagaaga tgaatacaaa caatggaaac     1260

tgaatgctcc agtcaacaaa ctatttctta tatatgtgaa catttatcaa tcagtataat     1320

tctgtactga tttttgtaag acaatccatg taaggtatca gttgcaataa tacttctcaa     1380

acctgtttaa atatttcaag acattaaatc tatgaagtat ataatggttt caaagattca     1440

aaattgacat tgctttactg tcaaaataat tttatggctc actatgaatc tattatactg     1500

tattaagagt gaaaattgtc ttcttctgtg ctggagatgt tttagagtta acaatgatat     1560

atggataatg ccggtgagaa taagagagtc ataaacctta agtaagcaac agcataacaa     1620

ggtccaagat acctaaaaga gatttcaaga gatttaatta atcatgaatg tgtaacacag     1680

tgccttcaat aaatggtata gcaaatgttt tgacatgaaa aaaggacaat ttcaaaaaaa     1740

taaaataaaa taaaaataaa ttcacctagt ctaaggatgc taaaccttag tactgagtta     1800

cattgtcatt tatatagatt ataacttgtc taaataagtt tgcaatttgg gagatatatt     1860

tttaagataa taatatatgt ttacctttta attaatgaaa tatctgtatt taattttgac     1920

actatatctg tatataaaat attttcatac agcattacaa attgcttact ttggaataca     1980

tttctccttt gataaaataa atgagctatg tattaa                               2016


<210>  25
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of IL-7

<400>  25

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  26
<211>  12846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary nucleic acid sequence of MICA

<400>  26
tggtctgagc ggttctactg cggcaggtgc ttctgagagg cagaggtggc tgagatctgg       60

aaacaggtct gcaaatctgg tcactggtct cattgccagt aacgctgtgc gcggttgagg      120

gagtgtgttg ggagaatagc cacgcgttgt ctgtcctgga aggaacaagc cagtgagagc      180

cggtttaatg gggcggccgg cgaaaggggc ttggtgaggc ccgcgctcct cggggtgggg      240

gcgcggggat gggtggtcgc gatgccggga gggcaggcag ggccctgccc gtgcttatga      300

agttggagct gtactctcag ctactcgaag ctggtccctg ctttaggctg cgctcccgcg      360

tgctccccat tttctgggcc ccaggtcccg ccttctaaat ctccccaggt ctccagccca      420

ctggaatttt ctcttccaag cgtggccccg ccctctccgc tcgtgattgg ccctaagttc      480

cgggccccag tttcattgga tgagcggtcg ggggaccggg ccaggtgact aagtttccgc      540

ggcgccttct ccccggccac tgcttgagcc gctgagaggg tggcgacgtc ggggccatgg      600

ggctgggccc ggtcttcctg cttctggctg gcatcttccc ttttgcacct ccgggagctg      660

ctgctggtga gtggcgttcc tggcggtcct cggcggagcg ggagcagtgg gacgtttccg      720

ggggtcgggt gggtagcggc gagcgctgtg cggtcagggc gggcctcctg tgcgctgtcg      780

gtggcgcagg gagctggacg cggcccgtta ccgccacact tcagccctgc ttccccgtca      840

cttttcagtc ctcctcggga tcgcgcatca cctgcacttt ctggtctcct cctgctcttt      900

ctctcctcgc gtctcctccg cttcctctca cttttcggac aaaccagtcc ttctgaggcc      960

catgggttcc cgggctgcct ccggggctgc tcctgtgaat ggcattcgag tgcccttcca     1020

gcgcggccac tgaagcagcc acaacccccg gtgctcgggg cggctctcag gtccctgaag     1080

tcctgtcctc tcccggagcc gacgtgttct cagctcctgg gccgcagctc ctggagtagg     1140

ggccctcctt tctcgggacc cggagctggt gcttcctgct gctgtgggga ctgtgggggg     1200

tcctgactct caagctgagg ggttggagtc tgcaggctcc gggcagagga ttcttcctgc     1260

gacttctctc atccccagct cattctcccc tcgcctctgg ctccgagggt cctctcctct     1320

ctctcatccc acccctacta atgaccagtg atctaaggac accagattcc ctctcacctc     1380

ctccctgccc atctcagggc ccgctgagtc cttttgccct cccagctccc tgctacccct     1440

tcctgtgtgc tgttctctga tccatttcta gggtgtcctc tgccctcatc ccctgtcccc     1500

gccaccgaag gtccctcctg caccccttat gggcctttcc tacaagcagc cttcacccag     1560

tgctgcccct atgcctcccc gttcccaaat gtccctgact ctaactttct ggtgctgcct     1620

tttatccggg ggggtcttcc ctccatccca ctcccctcca cacccccaag gggaaccctg     1680

atgctaatgg cagttgggcc ttaggcaggg cgcagggcag cgcagatgcc ccctcccctc     1740

cagtgcagat gcctgctctg gaccctgcct cattgtggcc ccttccccac tccttcatcc     1800

tcagcctcac cctcttgagg accccaccct ccagcccaca ggtgctggac catccctccc     1860

tggtccctcc gcccctctcc accttgggac cttgtgctgc tcctatctct tgcccagctg     1920

ccttgggccc tcagcacgtt ctcatctttc agtgggaaag tgggagtgct ggagcatatg     1980

acagtgctga gcatctttcc caagccccac cctcccccag agcaccctcc cctcctgtcc     2040

tcaccctacc ccaagttctc ccacagtcac tcctgcccca tgctcatgcc gccctccagt     2100

tcttgctctg cccatctccc ctccccaacc cagacctaaa acaggctgtt gggccagctg     2160

ttccttgacc ttccttcttt tcttttggtt ccttgacccc agtgggctct cactccccac     2220

accgcatatc taaaatctgt tttgcctgct cttggggtgc cactgctccc cctccagcat     2280

tactcctttt ggcaggtcct tcctcaggct gagaatctcc ccctctacct tggttttctc     2340

tctctggcca gcacccccac cccttgcttt gtttttaatt tttaactttt gtttgggtac     2400

gtagtagata tatatgtata tatttatggg gtacatggga tattttcaca caggcctaca     2460

atatgtaata atcacatcag ggtaaatggg ttatatcaca acaagcattt atcctttctt     2520

tgtgctacaa acaatcccat tatgctcttt cagttatttt taaatgtaca ataaattatt     2580

gttgactgta ctcaccctgc tgtgctatct actagatctt attcattcta attatatttt     2640

tgtacccatt attaaccatc cctgctcccc cactccccac tacccttctc agcctctggt     2700

aatcatcatt ctattgtctc tccccatgag gtccattgtt ttaaattttg gctgccacaa     2760

ataagtgaga acatgcaaag tttgtctgtc tgggcctggg gcttatttca cttcacagga     2820

tgacctccag ttctttgcaa atgacacgat ggctgaatag ttctccacat acacatgtac     2880

accacatttt ctttatccat gcgtctgttg atggacactt agattgcttg cagatcttgg     2940

ctactttgaa tagtgctgca ataaacatgg aaaagtagat agctctttaa tataccgatt     3000

tcctttcttt ggagtatatg cctaacagtg ggagtgctgg agcatatgac agctctattg     3060

tatttttagt ttttggaaga acctccacat tgtttcccat agtggttgta ctagtttacg     3120

ttcccaccaa cagtgtacat cctcaccagc attccttatt tctacatcct cgccagcatt     3180

ccttattgcc tgtcttctgg ataaaagcca gtttatctgg ggtgggatgt tatctcgtag     3240

gagttttgat ttgccttcat ctgttgacga atgatgttga gcaccttttc atatacctgt     3300

ttgccattta tatgtcttct tttgagaaat gactattcag atcttttctc atttttaaat     3360

tggattatta tatttttttt tcctatagtt gttcgagctc cttatatgtt tcagttactg     3420

atcctttgtc agatgaatag tttgaaaata ttttctccca ttcttggatg gtctcttcat     3480

tttgtttatt gtttcctttg ctgtgcagaa gcctttttac ttgatatgat cccatttatg     3540

caattttact ttggttacct gtgcttgtgg ggtattactt taaaaatctt tgcccagtcc     3600

aatatcctag agagtttccc caatgttttc ttgtatagtt tcatagtttg aggtcataga     3660

tttacatctt taatccactt tgatttgatt tttgtatatg gtgaaagaca gggtctagtt     3720

tcattcttct gcataaggat atctagtttc cccagcacca tttttgaaga gactctcctt     3780

tgccaatgtg tgttcttggt acctttgttg gaaatgagtt tactgtagat gtatggaatt     3840

gtttctgggt tctctattct gtttcattgg tctgtgtgtc tgtttttatg ccagtatcat     3900

gctgttttgg ttactgtagc tctgtagtat aatttgaagt cagataatgt gattcctcta     3960

gttttgttca ttttgctcag gatagcttta tctattctgg tttttttgtg gttccatatg     4020

cattttagga ttatttttat tatttctgtg aagaatgtca ttagtgtttt gatagggatt     4080

gcattgaatc tgtagattac tttgggtagt atggatattt caacaaaact gattcttcca     4140

atccatgaac gtggactatc ttttccattt tttgtgtcct tcaatttttt gcatcagtgt     4200

tttttgtttt tggtttttga gatggagttt cactcttgtt gcccaggcta gaatgcaagg     4260

gtgtgatctt ggctcaccgc aacctccgcc tcccaggttc aagcgattct tctgcctcag     4320

cctcccaagt agctgggatt acaggcatgt gccactgtgc ctggctaatt ttctattttt     4380

attagagatg gggtttctct atgttggcca ggctagtctt gaactcctga cctcaggtga     4440

tccacctgcc tcggcctccc aaagtgctgg gattacaggc atgagccacc acgcccagcc     4500

acatcactgt tttatagttt ttattggaga ggtctttcac ttcttcagtt aggtttattc     4560

ctcagtattt tattttattt gtagctattg taaatgggat tcgtttcttg atttcttttt     4620

cagattattt gctgttagca ctgatttttg catgttgatt ttgtatcctg caactttact     4680

gaatttgttc ttcagttcta atggtttttt ggtggagtct ttaggttttt ccaaatatca     4740

gaccacatga tctgcaaaca aggataattt gacttcttct tttccagttt taatgccctt     4800

tctttctttc tcctgtctga ttgctctagt taggatctgc agtactgtgt tgcataactg     4860

tggtaaaatt agtcatcctt gtcttattcc agatcttaga gaaaaggctt tcagttttcc     4920

cccattcagt atgttactag ctgtgagttt gtcatatatg gcttttatta tattgaggtc     4980

tgttccttgt atacttagtt ttttgagagt ttttatcatg aagggatgtt gaatttatca     5040

aatgcttttt cagtatcaat tgaatgatac tggcttttgt cctttattct gttgatatga     5100

cgtattacat tgattgattt gtgtatgtta aatcatcctt gcatacctgg aatacattcc     5160

acttgctcat aaagaatgat cttttttaat gtattgttga atgtggtttg ctagtatttc     5220

cttgacgatt tttgcatcgg tgttcatcag ggatataggc ctgtagtttt cttttttatg     5280

atgtgtcttt gcctggtttt tgtatcagga tattcctggc tttgtaaaat gagtttggaa     5340

gtattccctc ctcctctatt tttcagaaca gtttgaatag gactgacata tgttgttctt     5400

taaaagttta attgtggtaa attatacatt acataaattt tactgtttta accactttta     5460

agtgtatact cggtggcatt agatacattc acatttttgt gcaacccaaa actctgtgcc     5520

cattaatcgg taactcccca ttcctcccta cctctggccc ctggtaacca ccattctact     5580

ttttgtttct atgaatttga ccactctagg tacctcattt aagcagaatc atgtaatgtt     5640

tgtctttttg tttctggctt atttcactta taatattttt gaggttcggt gggcacagtg     5700

gctcacgcct ggatttccag cactttggga ggctgaagca ggtggatcac ctgagtttcg     5760

gagttcgaaa ccagcctggc caacatggtg aaaccccatc tctactaaaa ataataaaag     5820

ttagccgggc gtgatggcgg gtgcctgtaa tcccaactac ttgggaggct gaggcaggag     5880

aatcgcttga atccgggaag tggaggttgc agtgagctga gatcaggcca ctgcactcca     5940

gcctgggcaa caagagtgaa attccatctc caaaaaaaaa aataaaacaa taataataat     6000

aatatttttg aggttcatcc aagttgtagt atgggtcaga atttcattcc ttttaaggat     6060

ggataatact cattatatgt atgtaccaca tcttggttat ccatccctca gacaacggac     6120

acttgggtta cttctacctt ttggatattg gcaaatattt catttccttt gggtatatat     6180

ttatttcctt tgggtatttc ttttgggtat atatccagaa atagaagcag tacatagggg     6240

cttcattttc tctgtctctt tgccaacctt gctctgtgtg tgtgtgtgta tgtgtgtgtg     6300

taggtgtgtg ataacagcca tcctgattgg tttcaggtgg catctcattg tggtttggat     6360

ttgcattttc ctaatgagtg ctgatattga gcatcttttc atgtgtttgt tgatcatttg     6420

taattttctt tgaagaattg gccatttaag tcttttgccc attttttccc ccacatagct     6480

tctcttatca gatatatgac ttgcaatatt tatttcattt cggggttgat tgctttttca     6540

ctctgattgt gccctttgat gcatagatgt tttgaatttt catcagtcta ctttgtcagt     6600

tctttctatt ctatctgtgc tttggtgtca tatccatgaa agcactgtca aatcctatgt     6660

catgaacatt atccccaatg tttgcttcta agaaattttt aggttttagt tcttgagtgt     6720

agagtttagg tctttgattc attttgagtt aatttttgta tatagtgcaa attaagggtc     6780

caattttatt ttaacacccc ctgcccccag aactatttgc tgaaaagatc aactgactct     6840

ttgtcacctg ctcaccccag tggacactag ctgttccatc caattgctgt cctggggcct     6900

tgtcatgcca ctcttccact ttgaacccaa gcccacaccg ttgctcccct ctgggatact     6960

gaccccacta taaacttcac tggggctaca accttcctac cctttgtgcc tcatgaccac     7020

cccctccctt gtccccacca tgcccatgat gagtctcttc tcgaggcagc tccccttgcc     7080

tccatctcac cctcacctat gcaccacagc cacactggac atgggtccct ctgagcctga     7140

gtcccttccc attcccacca tcccctctgg caagaccttc cttccaccac cttcatgctc     7200

ctcccttgcc cctgcagggc agcctctccc cttggcccct attcccttag ggggcttgtg     7260

gccacccagt ccttgcacct ggcctacaag tttgccatct tcattccccc ttcttctgtt     7320

catcagcccc ctcctctatc ctcccaccct cacagttttc tttgtatatg aaatcctcgt     7380

tcttgtccct ttgcccgtgt gcatttcctg cctcctcagg aaggttggga cagcagacct     7440

gtgtgttaaa catcaatgtg aagttacttc caggaagaag tttcacctgt gatttcctct     7500

tccccagagc cccacagtct tcgttataac ctcacggtgc tgtccgggga tggatctgtg     7560

cagtcagggt ttctcgctga ggtacatctg gatggtcagc ccttcctgcg ctgtgacagg     7620

cagaaatgca gggcaaagcc ccagggacag tgggcagaag atgtcctggg aaataagaca     7680

tgggacagag agaccaggga cttgacaggg aacggaaagg acctcaggat gaccctggct     7740

catatcaagg accagaaaga aggtgagagt cggcaggggc aagagtgact ggagaggcct     7800

tttccagaaa agttaggggc agagagcagg gacctgtatc tacccactgg atctggctca     7860

ggctgggggt gaggaatggg ggtcagtgga actcagcagg gaggtgagcc ggcactcagc     7920

ccacacaggg aggcatggag gagggccagg gaggcgtacc ccctgggctg agttcctcac     7980

ttgggtggaa aggtgatggg ttcgggaatg gagaagtcac tgctgggtgg gggcaggctt     8040

gcattccctc caggagatta gggtctgtga gatccatgaa gacaacagca ccaggagctc     8100

ccagcatttc tactacgatg gggagctctt cctctcccaa aacctggaga ctgaggaatg     8160

gacaatgccc cagtcctcca gagctcagac cttggccatg aacgtcagga atttcttgaa     8220

ggaagatgcc atgaagacca agacacacta tcacgctatg catgcagact gcctgcagga     8280

actacggcga tatctaaaat ccggcgtagt cctgaggaga acaggtaccg acgctggcca     8340

ggggctctcc tctccttcca attctgctag agttgcctca cctcccagat gtgtccaggg     8400

aaaccctccc tgtgctatgg atgaaggcat ttcctgttgg cacatcgtgt cctgattttc     8460

ctctattgtt agagccactg gataaagaca gtgggtcagg gactggacca tccagtgttg     8520

taatcagggc aagtagagga ccctccgaca gaatcctgag cctggggtgg gtgtcaggca     8580

ggagaggaag gcttcagggc cagggctgcc ccctctgcct cccagcctgc ccatcctgga     8640

gagttccctc ctggccccac aacccaggag tccacccctg acatccccct cctcagcatc     8700

aatgtgggga tcccagagcc tgaggccaca gtcccatggc ccatcctcct gccagcctgg     8760

aagaactggg ccccagagtg aggacagact tgcaggtcag gggtcccaga gggcttcagc     8820

cagagtgaga acagtgaaga gaaacagccc tgttcctctc ccctccttag aggggagcag     8880

ggcttcactg gctctgccct ttcttctcca gtgcccccca tggtgaatgt cacccgcagc     8940

gaggcctcag agggcaacat taccgtgaca tgcagggctt ctggcttcta tccctggaat     9000

atcacactga gctggcgtca ggatggggta tctttgagcc acgacaccca gcagtggggg     9060

gatgtcctgc ctgatgggaa tggaacctac cagacctggg tggccaccag gatttgccaa     9120

ggagaggagc agaggttcac ctgctacatg gaacacagcg ggaatcacag cactcaccct     9180

gtgccctctg gtgagcctag ggtgaccctg gagagggtca ggccagggta gggacagcag     9240

ggatggctgt ggctctctgc ccagtgtata acaagtccct tttttttcag ggaaagtgct     9300

ggtgcttcag agtcattggc agacattcca tgtttctgct gttgctgctg ctgctgctgc     9360

tgctgctgct atttttgtta ttattatttt ctacgtctgt tgttgtaaga agaaaacatc     9420

agctgcagag ggtccaggtg agaaaagcgg gcagtttctg gagatggtaa ggcccctgtc     9480

tgggcagtag ggtcccctca ttgctcctgc aaagataggc atgttggtga caaggcttct     9540

gtaacagggg atgaaagttg gggaatttgg gaagggaatg ggggcaacat ctccatctac     9600

acccataagt gctgcccaag cgagggtcaa acgcccagct gtggcatctt cctgctgcag     9660

gtgaggagtg ggcagcaggg agggctgcgg cgcctgctct gtccccatcc cggtctctgt     9720

gtctcttgga ctcactaggg cgcatccagg tggggtgagc tgggaatcac gtgctgaatg     9780

ctgaggacct ggatgatcac ggcctcagag ggagcaaata gtaaaggcag ctgtgatctg     9840

gggagggcca gaaactggag aggaatctga ggagaggcgg tgcccctatt cccttcctct     9900

ctgcatccct ctcccctatt tctccagcca ttggggcgga caccaagaaa aagacctatg     9960

aggcccagcc tgggggccct gcctgtgtag ccctttggag accccttgta acagggaggg    10020

tcctgagcac acatggccat ctctgtccac ttttcagctc cccatgcacc tcctccagga    10080

gctttcttgg ggttgtcgtg tcctctgcac cattcgaggc cctactcttt ccaggttccc    10140

acagcctggt ctccctgagt ttcttgcaga tgagatggat gagtagataa gcagatgtcc    10200

ctgggccatt tgaggagtgg ggcccagccc ctcatcaggg cagctgtggt ccctgttttc    10260

atcctacctc cgagtgtttt cttctccagt ccctgaggga cacagtcctc agggcccatg    10320

tttttggggc tttaatctgt gctctgtggc ctcaccttgc cctccctgag ccaatttccc    10380

tttctaaagg tggtcactgc ctggtaagtt tggagtaagg gacggtcaga atcatttccc    10440

ctacagtcag gttgtttgat gggggatgaa aagagacagc aggaagtttt gtgtttctgc    10500

aaagacagaa gcagttcagg ggacagtaag aggctggggt gtccaggagg gtgtgtctgg    10560

cagtagggtc gctggtttct catccttgaa cctaattgca ctgtcagtcg gcccctcagg    10620

cctgagcaga tgggaaggtt tgtcccctgc cctgcagtaa gagggccctg tccaggaggc    10680

acccataaca ggggcagtgc aggtctgtgg tcgctcctgc tctcacctgt ggcgtctccc    10740

gtagagggat tatcagttct ggttccctgt gggcaggaat ggtttcctca taggtcactg    10800

gagttttggc caggaaaaga gtatgaagtt catgtgccag tttctcaaaa ttcctgcttt    10860

caatgttgat gtcaagcaaa gatattcgta atttcagctc tataatctta ataggatttc    10920

ccctaatatt gtaaagcatc ttatatgaaa caggaacaca aatttctcaa aattcctgcg    10980

atgtccaata aagattttca taatttcggc tctccaatct taataggatt tcctaatact    11040

gtaaagcata ttaaatgaaa caggaaccca aatttggagc cccctctcca ggaggttctg    11100

tgtggagatg gtggctgtgg cagtggcagt tcccaggtgc agagggtggg cagaggcagc    11160

ctcaggctaa ggggtctccc ctactccaca tggagaaaat cccttgtagg ttgcaagggc    11220

agtggccggg tggaatccct gctagggaca gagcaggaag gcctcgcagc ctcaccaagc    11280

agcagccctg gggtggagct gcgtttccag ggttaagcgg accaggcagg agcagtggtt    11340

actcaacagc aggtcacagg cttgggttgt gagggtcagg agaggccagg cctcctcgag    11400

caaggtgggg gtcccagggt caggtcaggt gcagatcctg tggcagccac gtctttccat    11460

gctgggcctg ctgggccccc caggctttct gatggggtcc ccagttagga gctgcctgct    11520

cagggctggg aggggaggag cgctgagctg cagatagagg gcagagccca cagtgggcag    11580

ggcctgccct ggtgtgtagg tgcctctgca ggagaggagg gcctggggac tgagagcaag    11640

ggtcagggcc tctctttgag gaggcctctc actgtaacag gactggtcag gcctgagagg    11700

aggtcactgg gttccctctt gggtcttgtc ctttagtctt ggggcccttt ccctccctgc    11760

acgatgagtg gtgggcacag ggcaggggct gatgttgatg gagtgatggg agggaactgg    11820

taggggctgg gaaaagcaag gagggaggaa gaaaaaagtg ggggcctcat cttctctcag    11880

agaaagggcg aatctggttt tggagcaact gaagagagaa aagtccccag ggaataaaca    11940

caacactgca cccagtggag catttacccg tttccctctt ttctccagag ctcgtgagcc    12000

tgcaggtcct ggatcaacac ccagttggga cgagtgacca cagggatgcc acacagctcg    12060

gatttcagcc tctgatgtca gatcttgggt ccactggctc cactgagggc gcctagactc    12120

tacagccagg cagctgggat tcaattccct gcctggatct cacgagcact ttccctcttg    12180

gtgcctcagt ttcatgacct atgaaacaga gaaaataaaa gcacttattt attgttgttg    12240

gaggctgcaa aatgttagta gatatgaggc gtttgcagct gtaccatatt aattggtgtc    12300

attgtttctg ttgttttcgt attattattt ttttttttta agacagagtc tcaggccagg    12360

cacggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc ggatcacaag    12420

gtcaagagat cgagaccacc ctgatcaaca tggtgaaacc ctgtctctac taaaaataca    12480

aaaaattagc tgggcctggt ggcatgtgcc tgtagtccca gctactcagg agctgaggca    12540

ggaaaatcac ttgaacctgg gaggtggaga ttgcagtgag ctgagatcgc gccactgcac    12600

tccagcctgg cgacagagcg agactctgtc tcaaaaaaaa aaaaaaaaaa aaaaaaagac    12660

agagtctcac tctgtcaccc aggctgcagt tcagtgacat gatctcagct cgttgcagcc    12720

tccgcctccc gggttcaagc acttcttgtg cctcagcctc ccgagtagct ggggttacag    12780

acatgcacca ccatacccgg ctaatttttg catttttcat agagacagga ttttgccatg    12840

ttggcc                                                               12846


<210>  27
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary amino acid sequence of MICA

<400>  27

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Gly Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Glu Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Ala Ile Phe Val Ile Ile Ile Phe Tyr Val Cys Cys Cys 
                325                 330                 335     


Lys Lys Lys Thr Ser Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln 
            340                 345                 350         


Val Leu Asp Gln His Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr 
        355                 360                 365             


Gln Leu Gly Phe Gln Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser 
    370                 375                 380                 


Thr Glu Gly Ala 
385             


