                         SEQUENCE LISTING

<110>  Syngenta Participations AG
       Chae, Hyunsook Sarah
 
<120>  ENGINEERED PESTICIDAL PROTEINS

<130>  81787-WO-REG-ORG-P-1

<150>  US 62/807,941
<151>  2019-02-20

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  715
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BT-0022 sequence assembled from Bacillus genome mining

<400>  1

Met Lys Ser Lys Asn Gln Asn Met His Gln Ser Leu Ser Asn Asn Ala 
1               5                   10                  15      


Thr Val Asp Lys Asn Phe Thr Gly Ser Leu Glu Asn Asn Thr Asn Thr 
            20                  25                  30          


Glu Leu Gln Asn Phe Asn His Glu Gly Ile Glu Pro Phe Val Ser Val 
        35                  40                  45              


Ser Thr Ile Gln Thr Gly Ile Gly Ile Ala Gly Lys Ile Leu Gly Asn 
    50                  55                  60                  


Leu Gly Val Pro Phe Ala Gly Gln Val Ala Ser Leu Tyr Ser Phe Ile 
65                  70                  75                  80  


Leu Gly Glu Leu Trp Pro Lys Gly Lys Ser Gln Trp Glu Ile Phe Met 
                85                  90                  95      


Glu His Val Glu Glu Leu Ile Asn Gln Lys Ile Ser Thr Tyr Ala Arg 
            100                 105                 110         


Asn Lys Ala Leu Ala Asp Leu Lys Gly Leu Gly Asp Ala Leu Ala Val 
        115                 120                 125             


Tyr His Glu Ser Leu Glu Ser Trp Ile Lys Asn Arg Asn Asn Thr Arg 
    130                 135                 140                 


Thr Arg Ser Val Val Lys Ser Gln Tyr Ile Thr Leu Glu Leu Met Phe 
145                 150                 155                 160 


Val Gln Ser Leu Pro Ser Phe Ala Val Ser Gly Glu Glu Val Pro Leu 
                165                 170                 175     


Leu Pro Ile Tyr Ala Gln Ala Ala Asn Leu His Leu Leu Leu Leu Arg 
            180                 185                 190         


Asp Ala Ser Ile Phe Gly Lys Glu Trp Gly Leu Ser Asp Ser Glu Ile 
        195                 200                 205             


Ser Thr Phe Tyr Asn Arg Gln Val Glu Arg Thr Ser Asp Tyr Ser Asp 
    210                 215                 220                 


His Cys Thr Lys Trp Phe Asp Thr Gly Leu Asn Arg Leu Lys Gly Ser 
225                 230                 235                 240 


Asn Ala Glu Ile Trp Val Lys Tyr Asn Gln Phe Arg Arg Asp Met Thr 
                245                 250                 255     


Leu Met Val Leu Asp Leu Val Ala Leu Phe Gln Ser Tyr Asp Thr His 
            260                 265                 270         


Met Tyr Pro Ile Lys Thr Thr Ala Gln Leu Thr Arg Glu Val Tyr Thr 
        275                 280                 285             


Asn Ala Ile Gly Thr Val His Pro His Pro Ser Phe Thr Ser Thr Thr 
    290                 295                 300                 


Trp Tyr Asn Asn Asn Ala Pro Ser Phe Ser Ala Ile Glu Ala Ala Val 
305                 310                 315                 320 


Ile Arg Ser Pro His Leu Leu Asp Phe Leu Glu Gln Val Thr Ile Tyr 
                325                 330                 335     


Ser Leu Leu Ser Arg Trp Ser Asn Thr Gln Tyr Met Asn Met Trp Gly 
            340                 345                 350         


Gly His Lys Leu Glu Phe Arg Thr Ile Gly Gly Thr Leu Asn Thr Ser 
        355                 360                 365             


Thr Gln Gly Ser Thr Asn Thr Ser Ile Asn Pro Val Thr Leu Pro Phe 
    370                 375                 380                 


Thr Ser Arg Asp Ile Tyr Arg Thr Glu Ser Leu Ala Gly Leu Asn Leu 
385                 390                 395                 400 


Phe Leu Thr Gln Pro Val Asn Gly Val Pro Arg Val Asp Phe His Trp 
                405                 410                 415     


Lys Phe Val Thr His Pro Ile Ala Ser Asp Asn Phe Tyr Tyr Pro Gly 
            420                 425                 430         


Tyr Ala Gly Ile Gly Thr Gln Leu Gln Asp Ser Glu Asn Glu Leu Pro 
        435                 440                 445             


Pro Glu Thr Thr Gly Gln Pro Asn Tyr Glu Ser Tyr Ser His Arg Leu 
    450                 455                 460                 


Ser His Ile Gly Leu Ile Ser Ala Ser His Val Lys Ala Leu Val Tyr 
465                 470                 475                 480 


Ser Trp Thr His Arg Ser Ala Asp Arg Thr Asn Thr Ile His Ser Asp 
                485                 490                 495     


Ser Ile Thr Gln Ile Pro Leu Val Lys Ala His Thr Leu Gln Ser Gly 
            500                 505                 510         


Thr Thr Val Val Lys Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg 
        515                 520                 525             


Arg Thr Ser Gly Gly Pro Phe Ala Phe Ser Asn Val Asn Leu Asp Trp 
    530                 535                 540                 


Asn Leu Ser Gln Arg Tyr Arg Ala Arg Ile Arg Tyr Ala Ser Thr Thr 
545                 550                 555                 560 


Asn Leu Arg Met Tyr Val Thr Ile Ala Gly Glu Arg Ile Phe Ala Gly 
                565                 570                 575     


Gln Phe Asn Lys Thr Met Asn Thr Gly Asp Pro Leu Thr Phe Gln Ser 
            580                 585                 590         


Phe Ser Tyr Ala Thr Ile Asp Thr Ala Phe Thr Phe Pro Thr Lys Ala 
        595                 600                 605             


Ser Ser Leu Thr Val Gly Ala Asp Thr Phe Ser Ser Gly Asn Glu Val 
    610                 615                 620                 


Tyr Val Asp Arg Phe Glu Leu Ile Pro Val Thr Ala Thr Leu Glu Ala 
625                 630                 635                 640 


Val Thr Asp Leu Glu Arg Ala Gln Lys Ala Val His Glu Leu Phe Thr 
                645                 650                 655     


Ser Thr Asn Pro Gly Gly Leu Lys Thr Asp Val Ala Lys Asp His Tyr 
            660                 665                 670         


Thr Asn Thr Ile Ser Lys Ser Val Gln Ser Val Phe Arg Cys Arg Cys 
        675                 680                 685             


Ser Glu Arg Thr Arg Ile Tyr Arg Trp Gly Tyr Pro Ser Lys Lys Glu 
    690                 695                 700                 


Tyr Trp Tyr Ile Trp Gly Tyr Thr Ser Lys Tyr 
705                 710                 715 


<210>  2
<211>  1131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BT-0002 sequence assembled from Bacillus genome mining

<400>  2

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile Asn Pro Asn Ala Ile Ile Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala Phe Asn Leu His Ser Gly Ala Thr Val Val Arg Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Asn Thr Gly Thr Phe 
                485                 490                 495     


Ala Asp Met Arg Val Asn Ile Thr Gly Pro Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Val Arg Ile Arg Tyr Ala Ser Thr Thr Asp Leu Gln Phe Phe Thr Arg 
        515                 520                 525             


Ile Asn Gly Thr Ser Val Asn Gln Gly Asn Phe Gln Arg Thr Met Asn 
    530                 535                 540                 


Arg Gly Asp Asn Leu Glu Ser Gly Asn Phe Arg Thr Ala Gly Phe Ser 
545                 550                 555                 560 


Thr Pro Phe Ser Phe Ser Asn Ala Gln Ser Thr Phe Thr Leu Gly Thr 
                565                 570                 575     


Gln Ala Phe Ser Asn Gln Glu Val Tyr Ile Asp Arg Ile Glu Phe Val 
            580                 585                 590         


Pro Ala Glu Val Thr Phe Glu Ala Glu Ser Asp Leu Glu Arg Ala Gln 
        595                 600                 605             


Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys 
    610                 615                 620                 


Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val Glu 
625                 630                 635                 640 


Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu 
                645                 650                 655     


Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu Gln 
            660                 665                 670         


Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp Arg 
        675                 680                 685             


Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys Glu 
    690                 695                 700                 


Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr 
705                 710                 715                 720 


Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg Tyr 
                725                 730                 735     


Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr Leu 
            740                 745                 750         


Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr Gly 
        755                 760                 765             


Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly Glu 
    770                 775                 780                 


Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp Cys 
785                 790                 795                 800 


Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe Ser 
                805                 810                 815     


Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val 
            820                 825                 830         


Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu Gly 
        835                 840                 845             


Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu Ala 
    850                 855                 860                 


Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln Leu 
865                 870                 875                 880 


Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp 
                885                 890                 895     


Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr Asn 
            900                 905                 910         


Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg Glu 
        915                 920                 925             


Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp Ile 
    930                 935                 940                 


Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr Asp 
945                 950                 955                 960 


Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser Cys 
                965                 970                 975     


Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg Ser 
            980                 985                 990         


Val Leu Val Val Pro Glu Trp Glu  Ser Glu Val Ser Gln  Glu Val Arg 
        995                 1000                 1005             


Val Cys  Pro Gly Arg Gly Tyr  Ile Leu Arg Val Thr  Ala Tyr Lys 
    1010                 1015                 1020             


Glu Gly  Tyr Gly Glu Gly Cys  Val Thr Ile His Glu  Ile Glu Asp 
    1025                 1030                 1035             


Asn Thr  Asp Glu Leu Lys Phe  Ser Asn Cys Ile Glu  Glu Glu Val 
    1040                 1045                 1050             


Tyr Pro  Thr Asp Thr Gly Asn  Asp Tyr Thr Ala His  Gln Gly Thr 
    1055                 1060                 1065             


Thr Gly  Cys Ala Asp Ala Cys  Asn Ser Arg Asn Val  Gly Tyr Glu 
    1070                 1075                 1080             


Asp Gly  Tyr Glu Ile Asn Thr  Thr Ala Ser Val Asn  Tyr Lys Pro 
    1085                 1090                 1095             


Thr Tyr  Glu Glu Glu Met Tyr  Thr Asp Val Arg Arg  Asp Asn His 
    1100                 1105                 1110             


Cys Glu  Tyr Asp Arg Gly Tyr  Gly Asn His Thr Pro  Leu Pro Ala 
    1115                 1120                 1125             


Gly Tyr  Val 
    1130     


<210>  3
<211>  1174
<212>  PRT
<213>  Bacillus thuringiensis

<400>  3

Met Glu Asn Asn Ile Gln Asn Gln Cys Val Pro Tyr Asn Cys Leu Asn 
1               5                   10                  15      


Asn Pro Glu Val Glu Ile Leu Asn Glu Glu Arg Ser Thr Gly Arg Leu 
            20                  25                  30          


Pro Leu Asp Ile Ser Leu Ser Leu Thr Arg Phe Leu Leu Ser Glu Phe 
        35                  40                  45              


Val Pro Gly Val Gly Val Ala Phe Gly Leu Phe Asp Leu Ile Trp Gly 
    50                  55                  60                  


Phe Ile Thr Pro Ser Asp Trp Ser Leu Phe Leu Leu Gln Ile Glu Gln 
65                  70                  75                  80  


Leu Ile Glu Gln Arg Ile Glu Thr Leu Glu Arg Asn Arg Ala Ile Thr 
                85                  90                  95      


Thr Leu Arg Gly Leu Ala Asp Ser Tyr Glu Ile Tyr Ile Glu Ala Leu 
            100                 105                 110         


Arg Glu Trp Glu Ala Asn Pro Asn Asn Ala Gln Leu Arg Glu Asp Val 
        115                 120                 125             


Arg Ile Arg Phe Ala Asn Thr Asp Asp Ala Leu Ile Thr Ala Ile Asn 
    130                 135                 140                 


Asn Phe Thr Leu Thr Ser Phe Glu Ile Pro Leu Leu Ser Val Tyr Val 
145                 150                 155                 160 


Gln Ala Ala Asn Leu His Leu Ser Leu Leu Arg Asp Ala Val Ser Phe 
                165                 170                 175     


Gly Gln Gly Trp Gly Leu Asp Ile Ala Thr Val Asn Asn His Tyr Asn 
            180                 185                 190         


Arg Leu Ile Asn Leu Ile His Arg Tyr Thr Lys His Cys Leu Asp Thr 
        195                 200                 205             


Tyr Asn Gln Gly Leu Glu Asn Leu Arg Gly Thr Asn Thr Arg Gln Trp 
    210                 215                 220                 


Ala Arg Phe Asn Gln Phe Arg Arg Asp Leu Thr Leu Thr Val Leu Asp 
225                 230                 235                 240 


Ile Val Ala Leu Phe Pro Asn Tyr Asp Val Arg Thr Tyr Pro Ile Gln 
                245                 250                 255     


Thr Ser Ser Gln Leu Thr Arg Glu Ile Tyr Thr Ser Ser Val Ile Glu 
            260                 265                 270         


Asp Ser Pro Val Ser Ala Asn Ile Pro Asn Gly Phe Asn Arg Ala Glu 
        275                 280                 285             


Phe Gly Val Arg Pro Pro His Leu Met Asp Phe Met Asn Ser Leu Phe 
    290                 295                 300                 


Val Thr Ala Glu Thr Val Arg Ser Gln Thr Val Trp Gly Gly His Leu 
305                 310                 315                 320 


Val Ser Ser Arg Asn Thr Ala Gly Asn Arg Ile Asn Phe Pro Ser Tyr 
                325                 330                 335     


Gly Val Phe Asn Pro Gly Gly Ala Ile Trp Ile Ala Asp Glu Asp Pro 
            340                 345                 350         


Arg Pro Phe Tyr Arg Thr Leu Ser Asp Pro Val Phe Val Arg Gly Gly 
        355                 360                 365             


Phe Gly Asn Pro His Tyr Val Leu Gly Leu Arg Gly Val Ala Phe Gln 
    370                 375                 380                 


Gln Thr Gly Thr Asn His Thr Arg Thr Phe Arg Asn Ser Gly Thr Ile 
385                 390                 395                 400 


Asp Ser Leu Asp Glu Ile Pro Pro Gln Asp Asn Ser Gly Ala Pro Trp 
                405                 410                 415     


Asn Asp Tyr Ser His Val Leu Asn His Val Thr Phe Val Arg Trp Pro 
            420                 425                 430         


Gly Glu Ile Ser Gly Ser Asp Ser Trp Arg Ala Pro Met Phe Ser Trp 
        435                 440                 445             


Thr His Arg Ser Ala Thr Pro Thr Asn Thr Ile Asp Pro Glu Arg Ile 
    450                 455                 460                 


Thr Gln Ile Pro Leu Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr 
465                 470                 475                 480 


Val Val Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr 
                485                 490                 495     


Ser Gly Gly Pro Phe Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu 
            500                 505                 510         


Pro Gln Arg Tyr Arg Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu 
        515                 520                 525             


Arg Ile Tyr Val Thr Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe 
    530                 535                 540                 


Asn Lys Thr Met Asp Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser 
545                 550                 555                 560 


Tyr Ala Thr Ile Asn Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser 
                565                 570                 575     


Phe Thr Val Gly Ala Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile 
            580                 585                 590         


Asp Arg Phe Glu Leu Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr 
        595                 600                 605             


Asp Leu Glu Arg Ala Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Ile 
    610                 615                 620                 


Asn Gln Ile Gly Ile Lys Thr Asp Val Thr Asp Tyr His Ile Asp Gln 
625                 630                 635                 640 


Val Ser Asn Leu Val Asp Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu 
                645                 650                 655     


Lys Arg Glu Leu Ser Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp 
            660                 665                 670         


Glu Arg Asn Leu Leu Gln Asp Pro Asn Phe Lys Gly Ile Asn Arg Gln 
        675                 680                 685             


Leu Asp Arg Gly Trp Arg Gly Ser Thr Asp Ile Thr Ile Gln Arg Gly 
    690                 695                 700                 


Asp Asp Val Phe Lys Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp 
705                 710                 715                 720 


Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu 
                725                 730                 735     


Lys Pro Tyr Thr Arg Tyr Gln Leu Arg Gly Tyr Ile Glu Asp Ser Gln 
            740                 745                 750         


Asp Leu Glu Ile Tyr Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val 
        755                 760                 765             


Asn Val Leu Gly Thr Gly Ser Leu Trp Pro Leu Ser Val Gln Ser Pro 
    770                 775                 780                 


Ile Arg Lys Cys Gly Glu Pro Asn Arg Cys Ala Pro His Leu Glu Trp 
785                 790                 795                 800 


Asn Pro Asp Leu Asp Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His 
                805                 810                 815     


His Ser His His Phe Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu 
            820                 825                 830         


Asn Glu Asp Leu Asp Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp 
        835                 840                 845             


Gly His Ala Arg Leu Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu 
    850                 855                 860                 


Val Gly Glu Ala Leu Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg 
865                 870                 875                 880 


Asp Lys Arg Glu Lys Leu Glu Leu Glu Thr Asn Ile Val Tyr Lys Glu 
                885                 890                 895     


Ala Lys Glu Ser Val Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Gln 
            900                 905                 910         


Leu Gln Ala Asp Thr Asn Ile Ala Met Ile His Ala Ala Asp Lys Arg 
        915                 920                 925             


Val His Arg Ile Arg Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro 
    930                 935                 940                 


Gly Val Asn Val Asp Ile Phe Glu Glu Leu Lys Gly Arg Ile Phe Thr 
945                 950                 955                 960 


Ala Phe Phe Leu Tyr Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe 
                965                 970                 975     


Asn Asn Gly Leu Ser Cys Trp Asn Val Lys Gly His Val Asp Val Glu 
            980                 985                 990         


Glu Gln Asn Asn His Arg Ser Val  Leu Val Val Pro Glu  Trp Glu Ala 
        995                 1000                 1005             


Glu Val  Ser Gln Glu Val Arg  Val Cys Pro Gly Arg  Gly Tyr Ile 
    1010                 1015                 1020             


Leu Arg  Val Thr Ala Tyr Lys  Glu Gly Tyr Gly Glu  Gly Cys Val 
    1025                 1030                 1035             


Thr Ile  His Glu Ile Glu Asn  Asn Thr Asp Glu Leu  Lys Phe Ser 
    1040                 1045                 1050             


Asn Cys  Val Glu Glu Glu Val  Tyr Pro Asn Asn Thr  Val Thr Cys 
    1055                 1060                 1065             


Asn Asp  Tyr Thr Ala Asn Gln  Glu Glu Tyr Gly Gly  Ala Tyr Thr 
    1070                 1075                 1080             


Ser Arg  Asn Arg Gly Tyr Asp  Glu Thr Tyr Gly Ser  Asn Ser Ser 
    1085                 1090                 1095             


Val Pro  Ala Asp Tyr Ala Ser  Val Tyr Glu Glu Lys  Ser Tyr Thr 
    1100                 1105                 1110             


Asp Gly  Arg Arg Asp Asn Pro  Cys Glu Ser Asn Arg  Gly Tyr Gly 
    1115                 1120                 1125             


Asp Tyr  Thr Pro Leu Pro Ala  Gly Tyr Val Thr Lys  Glu Leu Glu 
    1130                 1135                 1140             


Tyr Phe  Pro Glu Thr Asp Lys  Val Trp Ile Glu Ile  Gly Glu Thr 
    1145                 1150                 1155             


Glu Gly  Thr Phe Ile Val Asp  Ser Val Glu Leu Leu  Leu Met Glu 
    1160                 1165                 1170             


Glu 
    


<210>  4
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  4

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile Asn Pro Asn Ala Ile Ile Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Phe Ser Asn Val Asn Leu Asp Trp Asn Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Met Tyr Val Thr 
        515                 520                 525             


Ile Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asp 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Thr Lys Ala Ser Ser Leu Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Val Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Ser Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  5
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  5

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile His Ser Asp Ser Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Phe Ser Asn Val Asn Leu Asp Trp Asn Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Met Tyr Val Thr 
        515                 520                 525             


Ile Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asp 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Thr Lys Ala Ser Ser Leu Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Val Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Ser Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  6
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  6

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Asp Arg Thr Asn Thr Ile His Ser Asp Ser Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Phe Ser Asn Val Asn Leu Asp Trp Asn Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Met Tyr Val Thr 
        515                 520                 525             


Ile Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asp 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Thr Lys Ala Ser Ser Leu Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Val Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Ser Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  7
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  7

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile Asn Pro Asn Ala Ile Ile Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Phe Ser Asn Val Asn Leu Asp Trp Asn Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Met Tyr Val Thr 
        515                 520                 525             


Ile Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asp 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Thr Lys Ala Ser Ser Leu Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Val Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Leu Glu Ala Val Thr Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  8
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  8

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile His Ser Asp Ser Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Phe Ser Asn Val Asn Leu Asp Trp Asn Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Met Tyr Val Thr 
        515                 520                 525             


Ile Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asp 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Thr Lys Ala Ser Ser Leu Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Val Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Leu Glu Ala Val Thr Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  9
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  9

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Asp Arg Thr Asn Thr Ile His Ser Asp Ser Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Phe Ser Asn Val Asn Leu Asp Trp Asn Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Met Tyr Val Thr 
        515                 520                 525             


Ile Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asp 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Thr Lys Ala Ser Ser Leu Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Val Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Leu Glu Ala Val Thr Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  10
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  10

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile His Ser Asp Ser Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Phe Ser Asn Val Asn Leu Asp Trp Asn Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Met Tyr Val Thr 
        515                 520                 525             


Ile Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asp 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Thr Lys Ala Ser Ser Leu Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Val Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  11
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  11

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Asp Arg Thr Asn Thr Ile His Ser Asp Ser Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Phe Ser Asn Val Asn Leu Asp Trp Asn Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Met Tyr Val Thr 
        515                 520                 525             


Ile Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asp 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Thr Lys Ala Ser Ser Leu Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Val Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  12
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  12

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile Asn Pro Asn Ala Ile Ile Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Arg Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr 
        515                 520                 525             


Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asp 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser Phe Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Ser Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  13
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  13

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile Asp Pro Glu Arg Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Arg Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr 
        515                 520                 525             


Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asp 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser Phe Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Ser Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  14
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  14

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Pro Thr Asn Thr Ile Asp Pro Glu Arg Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Arg Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr 
        515                 520                 525             


Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asp 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser Phe Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Ser Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  15
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  15

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile Asn Pro Asn Ala Ile Ile Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Arg Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr 
        515                 520                 525             


Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asp 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser Phe Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  16
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  16

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile Asp Pro Glu Arg Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Arg Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr 
        515                 520                 525             


Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asp 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser Phe Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  17
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  17

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Pro Thr Asn Thr Ile Asp Pro Glu Arg Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Arg Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr 
        515                 520                 525             


Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asp 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser Phe Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr Asp Leu Glu Arg Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr Gln Ile Asp Gln Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Lys Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Thr Ser Ile Asn Arg Gln Leu Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asn Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Val Glu Ser Pro Ile Gly Arg Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Val Pro His Ile Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Leu Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Gln 
865                 870                 875                 880 


Leu Gln Phe Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asp Ser His Tyr Asn Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Thr Met Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Asp 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Ile Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Ile Gln Gln Asn Asp His Arg 
            980                 985                 990         


Ser Val Leu Val Val Pro Glu Trp  Glu Ser Glu Val Ser  Gln Glu Val 
        995                 1000                 1005             


Arg Val  Cys Pro Gly Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr 
    1010                 1015                 1020             


Lys Glu  Gly Tyr Gly Glu Gly  Cys Val Thr Ile His  Glu Ile Glu 
    1025                 1030                 1035             


Asp Asn  Thr Asp Glu Leu Lys  Phe Ser Asn Cys Ile  Glu Glu Glu 
    1040                 1045                 1050             


Val Tyr  Pro Thr Asp Thr Gly  Asn Asp Tyr Thr Ala  His Gln Gly 
    1055                 1060                 1065             


Thr Thr  Gly Cys Ala Asp Ala  Cys Asn Ser Arg Asn  Val Gly Tyr 
    1070                 1075                 1080             


Glu Asp  Gly Tyr Glu Ile Asn  Thr Thr Ala Ser Val  Asn Tyr Lys 
    1085                 1090                 1095             


Pro Thr  Tyr Glu Glu Glu Met  Tyr Thr Asp Val Arg  Arg Asp Asn 
    1100                 1105                 1110             


His Cys  Glu Tyr Asp Arg Gly  Tyr Gly Asn His Thr  Pro Leu Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Val Thr Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp 
    1130                 1135                 1140             


Thr Val  Trp Ile Glu Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val 
    1145                 1150                 1155             


Asp Ser  Val Glu Leu Leu Leu  Met Glu Glu 
    1160                 1165             


<210>  18
<211>  1169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  18

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile Asn Pro Asn Ala Ile Ile Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Arg Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr 
        515                 520                 525             


Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asp 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser Phe Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr Asp Leu Glu Lys Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Ser Asn Gln Ile Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr His Ile Asp Lys Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Cys Asp Glu Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Arg Gly Ile Asn Arg Gln Pro Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Ala Thr His Leu Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys 
865                 870                 875                 880 


Leu Glu Leu Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Lys Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Ala Ile Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr Ala Tyr Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Val Glu Glu Gln Asn Asn His 
            980                 985                 990         


Arg Ser Val Leu Val Val Pro Glu  Trp Glu Ala Glu Val  Ser Gln Glu 
        995                 1000                 1005             


Val Arg  Val Cys Pro Gly Arg  Gly Tyr Ile Leu Arg  Val Thr Ala 
    1010                 1015                 1020             


Tyr Lys  Glu Gly Tyr Gly Glu  Gly Cys Val Thr Ile  His Glu Ile 
    1025                 1030                 1035             


Glu Asp  Asn Thr Asp Glu Leu  Lys Phe Ser Asn Cys  Val Glu Glu 
    1040                 1045                 1050             


Glu Ile  Tyr Pro Asn Asn Thr  Val Thr Cys Asn Asp  Tyr Thr Ala 
    1055                 1060                 1065             


Thr Gln  Glu Glu Tyr Glu Gly  Thr Tyr Thr Ser Arg  Asn Arg Gly 
    1070                 1075                 1080             


Tyr Asp  Gly Ala Tyr Glu Ser  Asn Ser Ser Val Pro  Ala Asp Tyr 
    1085                 1090                 1095             


Ala Ser  Ala Tyr Glu Glu Lys  Ala Tyr Thr Asp Gly  Arg Arg Asp 
    1100                 1105                 1110             


Asn Thr  Cys Glu Ser Asn Arg  Gly Tyr Gly Asp Tyr  Thr Pro Leu 
    1115                 1120                 1125             


Pro Ala  Gly Tyr Val Thr Lys  Glu Leu Glu Tyr Phe  Pro Glu Thr 
    1130                 1135                 1140             


Asp Lys  Val Trp Ile Glu Ile  Gly Glu Thr Glu Gly  Thr Phe Ile 
    1145                 1150                 1155             


Val Asp  Ser Val Glu Leu Leu  Leu Met Glu Glu 
    1160                 1165                 


<210>  19
<211>  3510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  19
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaaccact acaaatacaa ttaatccaaa tgctattatc     1380

caaataccgt tagtaaaagc acatacactt cagtcaggta ctactgttgt aagagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttatactatt     1500

gttaatataa atgggcaatt accccaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatttacgt aacggttgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatgg ataccggtga cccattaaca ttccaatctt ttagttacgc aactattaat     1680

acagctttta cattcccaat gagccagagt agtttcacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatat agacagattt gaattgattc cagttactgc aacatttgag     1800

gcagaatatg atttagagaa agctcagaaa gcggtgaatg cgctgtttac ttcttccaat     1860

caaatcgggt taaaaacaga tgtgacggac tatcatattg ataaagtatc caatctagtt     1920

gagtgtttat cagatgaatt ttgtctagat gaaaagcgag aattgtccga gaaagtcaaa     1980

catgcgaagc gactctgtga tgagcggaat ttacttcaag atccaaactt cagaggcatc     2040

aatagacaac cagaccgtgg ttggagagga agtacggata ttaccatcca aggaggagat     2100

gacgtattca aagagaatta cgttacgcta ccgggtacct ttgatgagtg ctatccaacg     2160

tatttatatc aaaaaataga tgagtcgaaa ttaaaagcct atacccgcta tgaattaaga     2220

gggtatatcg aggatagtca agacttagaa atctatttaa ttcgctacaa tgcaaaacat     2280

gaaacagtaa atgtgccagg tacgggttcc ttatggccgc tttcagccca aagtccaatc     2340

ggaaagtgtg gagaaccgaa tcgatgtgcg acacaccttg aatggaatcc tgacttagat     2400

tgttcgtgta gggatggaga aaagtgtgcc catcattcgc atcatttctc cttagacatt     2460

gatgtaggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaag     2520

acgcaagatg gtcatgcgag actaggaaat ctagaatttc tcgaagagaa accattagta     2580

ggagaagcgc tagctcgtgt gaagagagcg gagaaaaaat ggagagacaa acgcgaaaaa     2640

ttggaattgg aaacaaatat tgtttataaa gaggcaaaaa aatctgtaga tgctttattt     2700

gtgaactctc aatatgatag attacaagcg gatacgaata tcgcgataat tcatgcggca     2760

gataaacgcg ttcatagcat tcgagaagca tatcttccag agttgtctgt aattccgggt     2820

gtaaatgcag ctatttttga agaattagag ggacgtattt tcacagccta ctctctatat     2880

gatgcgagaa atgtcattaa aaatggcgat ttcaataatg gcttatcatg ctggaacgtg     2940

aaagggcatg tagatgtaga agaacagaac aaccatcgtt cggtccttgt tgttccagaa     3000

tgggaagcag aagtgtcaca agaggttcgt gtctgtccag gtcgtggcta tatccttcgt     3060

gttacagcgt acaaagaggg atatggagag ggctgtgtaa cgattcatga gatcgaagac     3120

aatacagacg aactgaaatt cagcaactgt gtagaagagg aaatatatcc aaacaacacg     3180

gtaacgtgta atgattatac tgcgactcaa gaagaatatg agggtacgta cacttctcgt     3240

aatcgaggat atgacggagc ctatgaaagc aattcttctg taccagctga ttatgcatca     3300

gcctatgaag aaaaagcgta tacagatgga agaagagaca atacttgtga atctaacaga     3360

ggatatgggg attacacacc actaccagct ggctatgtga caaaagaatt agagtacttc     3420

ccagaaaccg ataaggtatg gattgagatt ggagaaacgg aaggaacatt tatcgtggac     3480

agcgtggaat tactccttat ggaggaatag                                      3510


<210>  20
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  20
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaaccact acaaatacaa ttaatccaaa tgctattatc     1380

caaataccac tagtaaaagc acatacactt cagtcaggta ctactgttgt aaaagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttttagtaat     1500

gttaatttag actggaattt atcacaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatgtacgt aacgattgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatga ataccggtga cccattaaca ttccaatctt ttagttacgc aactattgat     1680

acagctttta cattcccaac gaaagctagt agtttgacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatgt agacagattt gaattgattc cagttactgc aacattcgag     1800

gcagaatctg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  21
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  21
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaaccact acaaatacaa ttcattcaga tagtattact     1380

caaataccat tggtaaaagc acatacactt cagtcaggta ctactgttgt aaaagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttttagtaat     1500

gttaatttag actggaattt atcacaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatgtacgt aacgattgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatga ataccggtga cccattaaca ttccaatctt ttagttacgc aactattgat     1680

acagctttta cattcccaac gaaagctagt agtttgacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatgt agacagattt gaattgattc cagttactgc aacattcgag     1800

gcagaatctg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  22
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  22
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcagatcgt acaaatacaa ttcattcaga tagtattact     1380

caaataccat tggtaaaagc acatacactt cagtcaggta ctactgttgt aaaagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttttagtaat     1500

gttaatttag actggaattt atcacaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatgtacgt aacgattgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatga ataccggtga cccattaaca ttccaatctt ttagttacgc aactattgat     1680

acagctttta cattcccaac gaaagctagt agtttgacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatgt agacagattt gaattgattc cagttactgc aacattcgag     1800

gcagaatctg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  23
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  23
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaaccact acaaatacaa ttaatccaaa tgctattatc     1380

caaataccac tagtaaaagc acatacactt cagtcaggta ctactgttgt aaaagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttttagtaat     1500

gttaatttag actggaattt atcacaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatgtacgt aacgattgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatga ataccggtga cccattaaca ttccaatctt ttagttacgc aactattgat     1680

acagctttta cattcccaac gaaagctagt agtttgacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatgt agacagattt gaattgattc cagttactgc aacacttgaa     1800

gcagtaactg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  24
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  24
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaaccact acaaatacaa ttcattcaga tagtattact     1380

caaataccat tggtaaaagc acatacactt cagtcaggta ctactgttgt aaaagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttttagtaat     1500

gttaatttag actggaattt atcacaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatgtacgt aacgattgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatga ataccggtga cccattaaca ttccaatctt ttagttacgc aactattgat     1680

acagctttta cattcccaac gaaagctagt agtttgacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatgt agacagattt gaattgattc cagttactgc aacacttgaa     1800

gcagtaactg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  25
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  25
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcagatcgt acaaatacaa ttcattcaga tagtattact     1380

caaataccat tggtaaaagc acatacactt cagtcaggta ctactgttgt aaaagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttttagtaat     1500

gttaatttag actggaattt atcacaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatgtacgt aacgattgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatga ataccggtga cccattaaca ttccaatctt ttagttacgc aactattgat     1680

acagctttta cattcccaac gaaagctagt agtttgacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatgt agacagattt gaattgattc cagttactgc aacacttgaa     1800

gcagtaactg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  26
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  26
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaaccact acaaatacaa ttcattcaga tagtattact     1380

caaataccat tggtaaaagc acatacactt cagtcaggta ctactgttgt aaaagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttttagtaat     1500

gttaatttag actggaattt atcacaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatgtacgt aacgattgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatga ataccggtga cccattaaca ttccaatctt ttagttacgc aactattgat     1680

acagctttta cattcccaac gaaagctagt agtttgacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatgt agacagattt gaattgattc cagttactgc aacattcgag     1800

gcagaatatg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  27
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  27
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcagatcgt acaaatacaa ttcattcaga tagtattact     1380

caaataccat tggtaaaagc acatacactt cagtcaggta ctactgttgt aaaagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttttagtaat     1500

gttaatttag actggaattt atcacaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatgtacgt aacgattgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatga ataccggtga cccattaaca ttccaatctt ttagttacgc aactattgat     1680

acagctttta cattcccaac gaaagctagt agtttgacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatgt agacagattt gaattgattc cagttactgc aacattcgag     1800

gcagaatatg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  28
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  28
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaaccact acaaatacaa ttaatccaaa tgctattatc     1380

caaataccac tagtaaaagc acatacactt cagtcaggta ctactgttgt aagagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttatactatt     1500

gttaatataa atgggcaatt accccaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatttacgt aacggttgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatgg ataccggtga cccattaaca ttccaatctt ttagttacgc aactattaat     1680

acagctttta cattcccaat gagccagagt agtttcacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatat agacagattt gaattgattc cagttactgc aacattcgag     1800

gcagaatctg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  29
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  29
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaaccact acaaatacaa ttgatccgga gaggattact     1380

caaataccat tggtaaaagc acatacactt cagtcaggta ctactgttgt aagagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttatactatt     1500

gttaatataa atgggcaatt accccaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatttacgt aacggttgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatgg ataccggtga cccattaaca ttccaatctt ttagttacgc aactattaat     1680

acagctttta cattcccaat gagccagagt agtttcacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatat agacagattt gaattgattc cagttactgc aacattcgag     1800

gcagaatctg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  30
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  30
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaacccct acaaatacaa ttgatccgga gaggattact     1380

caaataccat tggtaaaagc acatacactt cagtcaggta ctactgttgt aagagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttatactatt     1500

gttaatataa atgggcaatt accccaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatttacgt aacggttgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatgg ataccggtga cccattaaca ttccaatctt ttagttacgc aactattaat     1680

acagctttta cattcccaat gagccagagt agtttcacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatat agacagattt gaattgattc cagttactgc aacattcgag     1800

gcagaatctg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  31
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  31
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaaccact acaaatacaa ttaatccaaa tgctattatc     1380

caaataccac tagtaaaagc acatacactt cagtcaggta ctactgttgt aagagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttatactatt     1500

gttaatataa atgggcaatt accccaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatttacgt aacggttgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatgg ataccggtga cccattaaca ttccaatctt ttagttacgc aactattaat     1680

acagctttta cattcccaat gagccagagt agtttcacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatat agacagattt gaattgattc cagttactgc aacatttgaa     1800

gcagaatatg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  32
<211>  3507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Bt toxin

<400>  32
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaaccact acaaatacaa ttgatccgga gaggattact     1380

caaataccat tggtaaaagc acatacactt cagtcaggta ctactgttgt aagagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttatactatt     1500

gttaatataa atgggcaatt accccaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatttacgt aacggttgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatgg ataccggtga cccattaaca ttccaatctt ttagttacgc aactattaat     1680

acagctttta cattcccaat gagccagagt agtttcacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatat agacagattt gaattgattc cagttactgc aacatttgaa     1800

gcagaatatg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  33
<211>  3507
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Modified Bt toxin

<400>  33
atggagataa ataatcagaa gcaatgcata ccatataatt gcttaagtaa tcctgaggaa       60

gtacttttgg atggggagag gatattacct gatatcgatc cactcgaagt ttctttgtcg      120

cttttgcaat ttcttttgaa taactttgtt ccagggggag gctttatttc aggattagtt      180

gataaaatat ggggggcttt gagaccatct gaatgggact tatttcttgc acagattgaa      240

cggttgattg atcaaagaat agaagcaaca gtaagagcaa aagcaatcgc tgaattagaa      300

ggtttaggga gaagttatca actatatgga gaggcattta aagagtggga aaaaactcca      360

gataacacag cggctcggtc tagagtaact gagagatttc gtataattga tgctcaaatt      420

gaagcaaata tcccttcgtt tcgggtttcc ggatttgaag tgccacttct attggtttat      480

acccaagcag ctaatttgca tctcgctcta ttaagagatt ctgttgtttt tggagagaga      540

tggggattga cgactacaaa tgtcaatgat atctataata gacaagttaa tagaattggt      600

gaatatagca atcattgcgt agatacgtat aacacagaac tagaacgtct agggtttaga      660

tctatagcgc agtggagaat atataatcag tttagaagag aactaacact aactgtatta      720

gatattgtcg ctcttttccc gaactatgac agtagactgt atccgatcca aactttttct      780

caattgacaa gagaaattgt tacatcccca gtaagcgaat tttattatgg tgttattaat      840

agtggtaata taaatggtac tcttactgaa cagcagataa ggcgaccaca tcttatggac      900

ttctttaact ccatgatcat gtatacatca gataatagac gggaacatta ttggtcagga      960

cttgaaatga cggcttattt tacaggattt gcaggcgctc aagtgtcatt ccctttagtc     1020

gggactagag gggagtcagc tccaccatta actgttagaa gtgttaatga tggaatttat     1080

agaatattat cggcaccgtt ttattcagcg ccttttctag gcaccattgt attgggaagt     1140

cgtggagaaa aatttgattt tgcgcttaat aatatttcac ctccgccatc tacaatatac     1200

agacatcctg gaacagtaga ttcactagtc agtataccgc cacaggataa tagcgtacca     1260

ccgcacaggg gatctagtca tcgattaagt catgttacaa tgcgcgcaag ttcccctata     1320

ttccattgga cgcatcgcag cgcaacccct acaaatacaa ttgatccgga gaggattact     1380

caaataccat tggtaaaagc acatacactt cagtcaggta ctactgttgt aagagggccc     1440

gggtttacgg gaggagatat tcttcgacga acaagtggag gaccatttgc ttatactatt     1500

gttaatataa atgggcaatt accccaaagg tatcgtgcaa gaatacgcta tgcctctact     1560

acaaatctaa gaatttacgt aacggttgca ggtgaacgga tttttgctgg tcaatttaac     1620

aaaacaatgg ataccggtga cccattaaca ttccaatctt ttagttacgc aactattaat     1680

acagctttta cattcccaat gagccagagt agtttcacag taggtgctga tacttttagt     1740

tcagggaatg aagtttatat agacagattt gaattgattc cagttactgc aacatttgaa     1800

gcagaatatg atttagaaag agcgcaaaag gcggtgaatg ccctgtttac ttctacaaac     1860

caactagggc taaaaacaga tgtgacggat tatcagattg atcaagtgtc caatttagta     1920

gaatgtttat cagatgaatt ttgtctggat gaaaagagag aattgtccga gaaagtcaaa     1980

catgcaaagc gacttagtga taagcggaac ctacttcaag atccaaactt cacatctatc     2040

aatagacaac tagaccgtgg atggagagga agtacggata ttaccatcca aggaggaaat     2100

gacgtattca aagagaatta cgtcacacta ccaggtacct ttgatgagtg ttatccaacg     2160

tatttgtatc aaaaaataga tgagtcaaaa ttaaaagcct atactcgcta tgaattaaga     2220

gggtatattg aagatagtca agatttagaa gtctatttga ttcgttacaa tgcgaaacat     2280

gaaacagtaa atgttcccgg tacagggtcc ttatggccgc tttcagtcga aagcccaatc     2340

ggaaggtgcg gagaaccgaa tcgatgtgtg ccacatattg aatggaatcc tgatttagat     2400

tgttcgtgta gggatgggga gaagtgtgcc catcattcgc atcatttctc tctagatatt     2460

gatgttggat gtacagacct aaatgaggac ctaggtgtat gggtgatctt taagattaaa     2520

acgcaggatg gccatgcaag attaggaaat ctagagtttc tcgaagagaa accattgtta     2580

ggagaagcgt tagctcgtgt gaaaagagcg gagaaaaaat ggagagacaa acgcgaacaa     2640

ttgcagtttg aaacgaatat cgtttacaaa gaggcaaaag aatctgtaga tgctttattc     2700

gtagattctc actataatag attacaagcg gatacgaaca ttacgatgat tcatgcggca     2760

gataaacgcg ttcatcgaat ccgagaggct tatcttccgg aattatccgt tatcccaggt     2820

gtaaatgcgg acatttttga agaattagaa ggtcttattt tcactgcatt ctccctatat     2880

gatgcgagaa atatcattaa aaacggtgat ttcaataatg gtttatcgtg ttggaacgtg     2940

aaagggcatg tagatataca acagaatgat catcgttctg tcctcgttgt cccggaatgg     3000

gaatcagagg tatcacaaga agtccgcgta tgtccaggtc gtggctatat tcttcgtgtc     3060

acagcgtaca aagagggcta cggagaagga tgcgtaacga tccatgagat cgaagacaat     3120

acagacgaat tgaagtttag taactgcata gaagaggaag tctatccaac ggatacaggt     3180

aatgattata ctgcacacca aggtacaaca ggatgcgcag atgcatgtaa ttcccgtaat     3240

gttggatatg aggatggata tgaaataaat actacagcat ctgttaatta caaaccgact     3300

tatgaagaag aaatgtatac agatgtacga agagataatc attgtgaata tgacagagga     3360

tatgggaacc atacaccgtt accagctggt tatgtaacaa aagaattaga gtacttccct     3420

gaaacagata cagtatggat agagattgga gaaacggaag gaacattcat cgtagatagt     3480

gtggaattac tcctcatgga ggaataa                                         3507


<210>  34
<211>  1169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BT2-BT2-Cry1Fa-BT29 full-length engineered Cry protein

<400>  34

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile Asp Pro Glu Arg Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Arg Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr 
        515                 520                 525             


Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asp 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser Phe Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr Asp Leu Glu Lys Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Ser Asn Gln Ile Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr His Ile Asp Lys Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Cys Asp Glu Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Arg Gly Ile Asn Arg Gln Pro Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Ala Thr His Leu Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys 
865                 870                 875                 880 


Leu Glu Leu Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Lys Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Ala Ile Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr Ala Tyr Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Val Glu Glu Gln Asn Asn His 
            980                 985                 990         


Arg Ser Val Leu Val Val Pro Glu  Trp Glu Ala Glu Val  Ser Gln Glu 
        995                 1000                 1005             


Val Arg  Val Cys Pro Gly Arg  Gly Tyr Ile Leu Arg  Val Thr Ala 
    1010                 1015                 1020             


Tyr Lys  Glu Gly Tyr Gly Glu  Gly Cys Val Thr Ile  His Glu Ile 
    1025                 1030                 1035             


Glu Asp  Asn Thr Asp Glu Leu  Lys Phe Ser Asn Cys  Val Glu Glu 
    1040                 1045                 1050             


Glu Ile  Tyr Pro Asn Asn Thr  Val Thr Cys Asn Asp  Tyr Thr Ala 
    1055                 1060                 1065             


Thr Gln  Glu Glu Tyr Glu Gly  Thr Tyr Thr Ser Arg  Asn Arg Gly 
    1070                 1075                 1080             


Tyr Asp  Gly Ala Tyr Glu Ser  Asn Ser Ser Val Pro  Ala Asp Tyr 
    1085                 1090                 1095             


Ala Ser  Ala Tyr Glu Glu Lys  Ala Tyr Thr Asp Gly  Arg Arg Asp 
    1100                 1105                 1110             


Asn Thr  Cys Glu Ser Asn Arg  Gly Tyr Gly Asp Tyr  Thr Pro Leu 
    1115                 1120                 1125             


Pro Ala  Gly Tyr Val Thr Lys  Glu Leu Glu Tyr Phe  Pro Glu Thr 
    1130                 1135                 1140             


Asp Lys  Val Trp Ile Glu Ile  Gly Glu Thr Glu Gly  Thr Phe Ile 
    1145                 1150                 1155             


Val Asp  Ser Val Glu Leu Leu  Leu Met Glu Glu 
    1160                 1165                 


<210>  35
<211>  1169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BT2-BT2-BT22-BT29 full-length engineered Cry protein

<400>  35

Met Glu Ile Asn Asn Gln Lys Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Glu Val Leu Leu Asp Gly Glu Arg Ile Leu Pro Asp Ile 
            20                  25                  30          


Asp Pro Leu Glu Val Ser Leu Ser Leu Leu Gln Phe Leu Leu Asn Asn 
        35                  40                  45              


Phe Val Pro Gly Gly Gly Phe Ile Ser Gly Leu Val Asp Lys Ile Trp 
    50                  55                  60                  


Gly Ala Leu Arg Pro Ser Glu Trp Asp Leu Phe Leu Ala Gln Ile Glu 
65                  70                  75                  80  


Arg Leu Ile Asp Gln Arg Ile Glu Ala Thr Val Arg Ala Lys Ala Ile 
                85                  90                  95      


Ala Glu Leu Glu Gly Leu Gly Arg Ser Tyr Gln Leu Tyr Gly Glu Ala 
            100                 105                 110         


Phe Lys Glu Trp Glu Lys Thr Pro Asp Asn Thr Ala Ala Arg Ser Arg 
        115                 120                 125             


Val Thr Glu Arg Phe Arg Ile Ile Asp Ala Gln Ile Glu Ala Asn Ile 
    130                 135                 140                 


Pro Ser Phe Arg Val Ser Gly Phe Glu Val Pro Leu Leu Leu Val Tyr 
145                 150                 155                 160 


Thr Gln Ala Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ser Val Val 
                165                 170                 175     


Phe Gly Glu Arg Trp Gly Leu Thr Thr Thr Asn Val Asn Asp Ile Tyr 
            180                 185                 190         


Asn Arg Gln Val Asn Arg Ile Gly Glu Tyr Ser Asn His Cys Val Asp 
        195                 200                 205             


Thr Tyr Asn Thr Glu Leu Glu Arg Leu Gly Phe Arg Ser Ile Ala Gln 
    210                 215                 220                 


Trp Arg Ile Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val Leu 
225                 230                 235                 240 


Asp Ile Val Ala Leu Phe Pro Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Gln Thr Phe Ser Gln Leu Thr Arg Glu Ile Val Thr Ser Pro Val Ser 
            260                 265                 270         


Glu Phe Tyr Tyr Gly Val Ile Asn Ser Gly Asn Ile Asn Gly Thr Leu 
        275                 280                 285             


Thr Glu Gln Gln Ile Arg Arg Pro His Leu Met Asp Phe Phe Asn Ser 
    290                 295                 300                 


Met Ile Met Tyr Thr Ser Asp Asn Arg Arg Glu His Tyr Trp Ser Gly 
305                 310                 315                 320 


Leu Glu Met Thr Ala Tyr Phe Thr Gly Phe Ala Gly Ala Gln Val Ser 
                325                 330                 335     


Phe Pro Leu Val Gly Thr Arg Gly Glu Ser Ala Pro Pro Leu Thr Val 
            340                 345                 350         


Arg Ser Val Asn Asp Gly Ile Tyr Arg Ile Leu Ser Ala Pro Phe Tyr 
        355                 360                 365             


Ser Ala Pro Phe Leu Gly Thr Ile Val Leu Gly Ser Arg Gly Glu Lys 
    370                 375                 380                 


Phe Asp Phe Ala Leu Asn Asn Ile Ser Pro Pro Pro Ser Thr Ile Tyr 
385                 390                 395                 400 


Arg His Pro Gly Thr Val Asp Ser Leu Val Ser Ile Pro Pro Gln Asp 
                405                 410                 415     


Asn Ser Val Pro Pro His Arg Gly Ser Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Met Arg Ala Ser Ser Pro Ile Phe His Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Thr Thr Asn Thr Ile His Ser Asp Ser Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Phe Ser Asn Val Asn Leu Asp Trp Asn Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Met Tyr Val Thr 
        515                 520                 525             


Ile Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asp 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Thr Lys Ala Ser Ser Leu Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Val Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr Asp Leu Glu Lys Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Ser Asn Gln Ile Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr His Ile Asp Lys Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Cys Asp Glu Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Arg Gly Ile Asn Arg Gln Pro Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Ala Thr His Leu Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys 
865                 870                 875                 880 


Leu Glu Leu Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Lys Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Ala Ile Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr Ala Tyr Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Val Glu Glu Gln Asn Asn His 
            980                 985                 990         


Arg Ser Val Leu Val Val Pro Glu  Trp Glu Ala Glu Val  Ser Gln Glu 
        995                 1000                 1005             


Val Arg  Val Cys Pro Gly Arg  Gly Tyr Ile Leu Arg  Val Thr Ala 
    1010                 1015                 1020             


Tyr Lys  Glu Gly Tyr Gly Glu  Gly Cys Val Thr Ile  His Glu Ile 
    1025                 1030                 1035             


Glu Asp  Asn Thr Asp Glu Leu  Lys Phe Ser Asn Cys  Val Glu Glu 
    1040                 1045                 1050             


Glu Ile  Tyr Pro Asn Asn Thr  Val Thr Cys Asn Asp  Tyr Thr Ala 
    1055                 1060                 1065             


Thr Gln  Glu Glu Tyr Glu Gly  Thr Tyr Thr Ser Arg  Asn Arg Gly 
    1070                 1075                 1080             


Tyr Asp  Gly Ala Tyr Glu Ser  Asn Ser Ser Val Pro  Ala Asp Tyr 
    1085                 1090                 1095             


Ala Ser  Ala Tyr Glu Glu Lys  Ala Tyr Thr Asp Gly  Arg Arg Asp 
    1100                 1105                 1110             


Asn Thr  Cys Glu Ser Asn Arg  Gly Tyr Gly Asp Tyr  Thr Pro Leu 
    1115                 1120                 1125             


Pro Ala  Gly Tyr Val Thr Lys  Glu Leu Glu Tyr Phe  Pro Glu Thr 
    1130                 1135                 1140             


Asp Lys  Val Trp Ile Glu Ile  Gly Glu Thr Glu Gly  Thr Phe Ile 
    1145                 1150                 1155             


Val Asp  Ser Val Glu Leu Leu  Leu Met Glu Glu 
    1160                 1165                 


