                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> GLYCOENGINEERING IMMUNOGLOBULIN E

<130> 29539-0492WO1

<140> PCT/US2020/018380
<141> 2020-02-14

<150> 62/808,449
<151> 2019-02-21

<150> 62/808,456
<151> 2019-02-21

<160> 73    

<170> PatentIn version 3.5

<210> 1
<211> 415
<212> PRT
<213> Homo sapiens

<400> 1
Met Thr Gly Glu Arg Pro Ser Thr Ala Leu Pro Asp Arg Arg Trp Gly 
1               5                   10                  15      


Pro Arg Ile Leu Gly Phe Trp Gly Gly Cys Arg Val Trp Val Phe Ala 
            20                  25                  30          


Ala Ile Phe Leu Leu Leu Ser Leu Ala Ala Ser Trp Ser Lys Ala Glu 
        35                  40                  45              


Asn Asp Phe Gly Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu Leu 
    50                  55                  60                  


Trp Val Ser Gly Arg Gln Ile Gly Ser Val Asp Thr Phe Arg Ile Pro 
65                  70                  75                  80  


Leu Ile Thr Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala 
                85                  90                  95      


Arg Lys Met Ser Ser Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu Arg 
            100                 105                 110         


Arg Ser Met Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile Val 
        115                 120                 125             


Asn Asp Gly Asp Val Pro Asp Gly Leu Asn Leu Gly Ala Val Val Ser 
    130                 135                 140                 


Asp Val Glu Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala His 
145                 150                 155                 160 


Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys Asp 
                165                 170                 175     


Asp Gly Val Ser Trp Ser Thr Pro Arg Asn Leu Ser Leu Asp Ile Gly 
            180                 185                 190         


Thr Glu Val Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln Arg 
        195                 200                 205             


Glu Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu Glu 
    210                 215                 220                 


Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser Trp 
225                 230                 235                 240 


Arg Tyr Gly Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys Gln 
                245                 250                 255     


Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp 
            260                 265                 270         


Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys His 
        275                 280                 285             


Cys Arg Ile Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg Pro 
    290                 295                 300                 


Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala Ala 
305                 310                 315                 320 


Gly Ala Val Val Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro Ala 
                325                 330                 335     


His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn 
            340                 345                 350         


Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro Ser 
        355                 360                 365             


Gly Tyr Ser Ser Leu Ala Thr Leu Glu Gly Ser Met Asp Gly Glu Glu 
    370                 375                 380                 


Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn His Tyr 
385                 390                 395                 400 


Thr Glu Ser Ile Ser Val Ala Lys Ile Ser Val Tyr Gly Thr Leu 
                405                 410                 415 


<210> 2
<211> 380
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Ser Leu Pro Val Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Ile Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 3
<211> 461
<212> PRT
<213> Homo sapiens

<400> 3
Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
1               5                   10                  15      


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Glu 
            20                  25                  30          


Val Met Glu Glu Val Thr Thr Cys Ser Phe Asn Ser Pro Leu Phe Arg 
        35                  40                  45              


Gln Glu Asp Asp Arg Gly Ile Thr Tyr Arg Ile Pro Ala Leu Leu Tyr 
    50                  55                  60                  


Ile Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr 
65                  70                  75                  80  


Arg Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg 
                85                  90                  95      


Ile Gly Gln Leu Val Gln Trp Gly Pro Leu Lys Pro Leu Met Glu Ala 
            100                 105                 110         


Thr Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Gln 
        115                 120                 125             


Lys Ser Gly Cys Val Phe Leu Phe Phe Ile Cys Val Arg Gly His Val 
    130                 135                 140                 


Thr Glu Arg Gln Gln Ile Val Ser Gly Arg Asn Ala Ala Arg Leu Cys 
145                 150                 155                 160 


Phe Ile Tyr Ser Gln Asp Ala Gly Cys Ser Trp Ser Glu Val Arg Asp 
                165                 170                 175     


Leu Thr Glu Glu Val Ile Gly Ser Glu Leu Lys His Trp Ala Thr Phe 
            180                 185                 190         


Ala Val Gly Pro Gly His Gly Ile Gln Leu Gln Ser Gly Arg Leu Val 
        195                 200                 205             


Ile Pro Ala Tyr Thr Tyr Tyr Ile Pro Ser Trp Phe Phe Cys Phe Gln 
    210                 215                 220                 


Leu Pro Cys Lys Thr Arg Pro His Ser Leu Met Ile Tyr Ser Asp Asp 
225                 230                 235                 240 


Leu Gly Val Thr Trp His His Gly Arg Leu Ile Arg Pro Met Val Thr 
                245                 250                 255     


Val Glu Cys Glu Val Ala Glu Val Thr Gly Arg Ala Gly His Pro Val 
            260                 265                 270         


Leu Tyr Cys Ser Ala Arg Thr Pro Asn Arg Cys Arg Ala Glu Ala Leu 
        275                 280                 285             


Ser Thr Asp His Gly Glu Gly Phe Gln Arg Leu Ala Leu Ser Arg Gln 
    290                 295                 300                 


Leu Cys Glu Pro Pro His Gly Cys Gln Gly Ser Val Val Ser Phe Arg 
305                 310                 315                 320 


Pro Leu Glu Ile Pro His Arg Cys Gln Asp Ser Ser Ser Lys Asp Ala 
                325                 330                 335     


Pro Thr Ile Gln Gln Ser Ser Pro Gly Ser Ser Leu Arg Leu Glu Glu 
            340                 345                 350         


Glu Ala Gly Thr Pro Ser Glu Ser Trp Leu Leu Tyr Ser His Pro Thr 
        355                 360                 365             


Ser Arg Lys Gln Arg Val Asp Leu Gly Ile Tyr Leu Asn Gln Thr Pro 
    370                 375                 380                 


Leu Glu Ala Ala Cys Trp Ser Arg Pro Trp Ile Leu His Cys Gly Pro 
385                 390                 395                 400 


Cys Gly Tyr Ser Asp Leu Ala Ala Leu Glu Glu Glu Gly Leu Phe Gly 
                405                 410                 415     


Cys Leu Phe Glu Cys Gly Thr Lys Gln Glu Cys Glu Gln Ile Ala Phe 
            420                 425                 430         


Arg Leu Phe Thr His Arg Glu Ile Leu Ser His Leu Gln Gly Asp Cys 
        435                 440                 445             


Thr Ser Pro Gly Arg Asn Pro Ser Gln Phe Lys Ser Asn 
    450                 455                 460     


<210> 4
<211> 484
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Val Pro Arg Thr Pro Ser Arg Thr Val Leu Phe Glu Arg Glu 
1               5                   10                  15      


Arg Thr Gly Leu Thr Tyr Arg Val Pro Ser Leu Leu Pro Val Pro Pro 
            20                  25                  30          


Gly Pro Thr Leu Leu Ala Phe Val Glu Gln Arg Leu Ser Pro Asp Asp 
        35                  40                  45              


Ser His Ala His Arg Leu Val Leu Arg Arg Gly Thr Leu Ala Gly Gly 
    50                  55                  60                  


Ser Val Arg Trp Gly Ala Leu His Val Leu Gly Thr Ala Ala Leu Ala 
65                  70                  75                  80  


Glu His Arg Ser Met Asn Pro Cys Pro Val His Asp Ala Gly Thr Gly 
                85                  90                  95      


Thr Val Phe Leu Phe Phe Ile Ala Val Leu Gly His Thr Pro Glu Ala 
            100                 105                 110         


Val Gln Ile Ala Thr Gly Arg Asn Ala Ala Arg Leu Cys Cys Val Ala 
        115                 120                 125             


Ser Arg Asp Ala Gly Leu Ser Trp Gly Ser Ala Arg Asp Leu Thr Glu 
    130                 135                 140                 


Glu Ala Ile Gly Gly Ala Val Gln Asp Trp Ala Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Gly Val Gln Leu Pro Ser Gly Arg Leu Leu Val Pro Ala 
                165                 170                 175     


Tyr Thr Tyr Arg Val Asp Arg Arg Glu Cys Phe Gly Lys Ile Cys Arg 
            180                 185                 190         


Thr Ser Pro His Ser Phe Ala Phe Tyr Ser Asp Asp His Gly Arg Thr 
        195                 200                 205             


Trp Arg Cys Gly Gly Leu Val Pro Asn Leu Arg Ser Gly Glu Cys Gln 
    210                 215                 220                 


Leu Ala Ala Val Asp Gly Gly Gln Ala Gly Ser Phe Leu Tyr Cys Asn 
225                 230                 235                 240 


Ala Arg Ser Pro Leu Gly Ser Arg Val Gln Ala Leu Ser Thr Asp Glu 
                245                 250                 255     


Gly Thr Ser Phe Leu Pro Ala Glu Arg Val Ala Ser Leu Pro Glu Thr 
            260                 265                 270         


Ala Trp Gly Cys Gln Gly Ser Ile Val Gly Phe Pro Ala Pro Ala Pro 
        275                 280                 285             


Asn Arg Pro Arg Asp Asp Ser Trp Ser Val Gly Pro Gly Ser Pro Leu 
    290                 295                 300                 


Gln Pro Pro Leu Leu Gly Pro Gly Val His Glu Pro Pro Glu Glu Ala 
305                 310                 315                 320 


Ala Val Asp Pro Arg Gly Gly Gln Val Pro Gly Gly Pro Phe Ser Arg 
                325                 330                 335     


Leu Gln Pro Arg Gly Asp Gly Pro Arg Gln Pro Gly Pro Arg Pro Gly 
            340                 345                 350         


Val Ser Gly Asp Val Gly Ser Trp Thr Leu Ala Leu Pro Met Pro Phe 
        355                 360                 365             


Ala Ala Pro Pro Gln Ser Pro Thr Trp Leu Leu Tyr Ser His Pro Val 
    370                 375                 380                 


Gly Arg Arg Ala Arg Leu His Met Gly Ile Arg Leu Ser Gln Ser Pro 
385                 390                 395                 400 


Leu Asp Pro Arg Ser Trp Thr Glu Pro Trp Val Ile Tyr Glu Gly Pro 
                405                 410                 415     


Ser Gly Tyr Ser Asp Leu Ala Ser Ile Gly Pro Ala Pro Glu Gly Gly 
            420                 425                 430         


Leu Val Phe Ala Cys Leu Tyr Glu Ser Gly Ala Arg Thr Ser Tyr Asp 
        435                 440                 445             


Glu Ile Ser Phe Cys Thr Phe Ser Leu Arg Glu Val Leu Glu Asn Val 
    450                 455                 460                 


Pro Ala Ser Pro Lys Pro Pro Asn Leu Gly Asp Lys Pro Arg Gly Cys 
465                 470                 475                 480 


Cys Trp Pro Ser 
                


<210> 5
<211> 781
<212> PRT
<213> Vibrio cholerae

<400> 5
Met Arg Phe Lys Asn Val Lys Lys Thr Ala Leu Met Leu Ala Met Phe 
1               5                   10                  15      


Gly Met Ala Thr Ser Ser Asn Ala Ala Leu Phe Asp Tyr Asn Ala Thr 
            20                  25                  30          


Gly Asp Thr Glu Phe Asp Ser Pro Ala Lys Gln Gly Trp Met Gln Asp 
        35                  40                  45              


Asn Thr Asn Asn Gly Ser Gly Val Leu Thr Asn Ala Asp Gly Met Pro 
    50                  55                  60                  


Ala Trp Leu Val Gln Gly Ile Gly Gly Arg Ala Gln Trp Thr Tyr Ser 
65                  70                  75                  80  


Leu Ser Thr Asn Gln His Ala Gln Ala Ser Ser Phe Gly Trp Arg Met 
                85                  90                  95      


Thr Thr Glu Met Lys Val Leu Ser Gly Gly Met Ile Thr Asn Tyr Tyr 
            100                 105                 110         


Ala Asn Gly Thr Gln Arg Val Leu Pro Ile Ile Ser Leu Asp Ser Ser 
        115                 120                 125             


Gly Asn Leu Val Val Glu Phe Glu Gly Gln Thr Gly Arg Thr Val Leu 
    130                 135                 140                 


Ala Thr Gly Thr Ala Ala Thr Glu Tyr His Lys Phe Glu Leu Val Phe 
145                 150                 155                 160 


Leu Pro Gly Ser Asn Pro Ser Ala Ser Phe Tyr Phe Asp Gly Lys Leu 
                165                 170                 175     


Ile Arg Asp Asn Ile Gln Pro Thr Ala Ser Lys Gln Asn Met Ile Val 
            180                 185                 190         


Trp Gly Asn Gly Ser Ser Asn Thr Asp Gly Val Ala Ala Tyr Arg Asp 
        195                 200                 205             


Ile Lys Phe Glu Ile Gln Gly Asp Val Ile Phe Arg Gly Pro Asp Arg 
    210                 215                 220                 


Ile Pro Ser Ile Val Ala Ser Ser Val Thr Pro Gly Val Val Thr Ala 
225                 230                 235                 240 


Phe Ala Glu Lys Arg Val Gly Gly Gly Asp Pro Gly Ala Leu Ser Asn 
                245                 250                 255     


Thr Asn Asp Ile Ile Thr Arg Thr Ser Arg Asp Gly Gly Ile Thr Trp 
            260                 265                 270         


Asp Thr Glu Leu Asn Leu Thr Glu Gln Ile Asn Val Ser Asp Glu Phe 
        275                 280                 285             


Asp Phe Ser Asp Pro Arg Pro Ile Tyr Asp Pro Ser Ser Asn Thr Val 
    290                 295                 300                 


Leu Val Ser Tyr Ala Arg Trp Pro Thr Asp Ala Ala Gln Asn Gly Asp 
305                 310                 315                 320 


Arg Ile Lys Pro Trp Met Pro Asn Gly Ile Phe Tyr Ser Val Tyr Asp 
                325                 330                 335     


Val Ala Ser Gly Asn Trp Gln Ala Pro Ile Asp Val Thr Asp Gln Val 
            340                 345                 350         


Lys Glu Arg Ser Phe Gln Ile Ala Gly Trp Gly Gly Ser Glu Leu Tyr 
        355                 360                 365             


Arg Arg Asn Thr Ser Leu Asn Ser Gln Gln Asp Trp Gln Ser Asn Ala 
    370                 375                 380                 


Lys Ile Arg Ile Val Asp Gly Ala Ala Asn Gln Ile Gln Val Ala Asp 
385                 390                 395                 400 


Gly Ser Arg Lys Tyr Val Val Thr Leu Ser Ile Asp Glu Ser Gly Gly 
                405                 410                 415     


Leu Val Ala Asn Leu Asn Gly Val Ser Ala Pro Ile Ile Leu Gln Ser 
            420                 425                 430         


Glu His Ala Lys Val His Ser Phe His Asp Tyr Glu Leu Gln Tyr Ser 
        435                 440                 445             


Ala Leu Asn His Thr Thr Thr Leu Phe Val Asp Gly Gln Gln Ile Thr 
    450                 455                 460                 


Thr Trp Ala Gly Glu Val Ser Gln Glu Asn Asn Ile Gln Phe Gly Asn 
465                 470                 475                 480 


Ala Asp Ala Gln Ile Asp Gly Arg Leu His Val Gln Lys Ile Val Leu 
                485                 490                 495     


Thr Gln Gln Gly His Asn Leu Val Glu Phe Asp Ala Phe Tyr Leu Ala 
            500                 505                 510         


Gln Gln Thr Pro Glu Val Glu Lys Asp Leu Glu Lys Leu Gly Trp Thr 
        515                 520                 525             


Lys Ile Lys Thr Gly Asn Thr Met Ser Leu Tyr Gly Asn Ala Ser Val 
    530                 535                 540                 


Asn Pro Gly Pro Gly His Gly Ile Thr Leu Thr Arg Gln Gln Asn Ile 
545                 550                 555                 560 


Ser Gly Ser Gln Asn Gly Arg Leu Ile Tyr Pro Ala Ile Val Leu Asp 
                565                 570                 575     


Arg Phe Phe Leu Asn Val Met Ser Ile Tyr Ser Asp Asp Gly Gly Ser 
            580                 585                 590         


Asn Trp Gln Thr Gly Ser Thr Leu Pro Ile Pro Phe Arg Trp Lys Ser 
        595                 600                 605             


Ser Ser Ile Leu Glu Thr Leu Glu Pro Ser Glu Ala Asp Met Val Glu 
    610                 615                 620                 


Leu Gln Asn Gly Asp Leu Leu Leu Thr Ala Arg Leu Asp Phe Asn Gln 
625                 630                 635                 640 


Ile Val Asn Gly Val Asn Tyr Ser Pro Arg Gln Gln Phe Leu Ser Lys 
                645                 650                 655     


Asp Gly Gly Ile Thr Trp Ser Leu Leu Glu Ala Asn Asn Ala Asn Val 
            660                 665                 670         


Phe Ser Asn Ile Ser Thr Gly Thr Val Asp Ala Ser Ile Thr Arg Phe 
        675                 680                 685             


Glu Gln Ser Asp Gly Ser His Phe Leu Leu Phe Thr Asn Pro Gln Gly 
    690                 695                 700                 


Asn Pro Ala Gly Thr Asn Gly Arg Gln Asn Leu Gly Leu Trp Phe Ser 
705                 710                 715                 720 


Phe Asp Glu Gly Val Thr Trp Lys Gly Pro Ile Gln Leu Val Asn Gly 
                725                 730                 735     


Ala Ser Ala Tyr Ser Asp Ile Tyr Gln Leu Asp Ser Glu Asn Ala Ile 
            740                 745                 750         


Val Ile Val Glu Thr Asp Asn Ser Asn Met Arg Ile Leu Arg Met Pro 
        755                 760                 765             


Ile Thr Leu Leu Lys Gln Lys Leu Thr Leu Ser Gln Asn 
    770                 775                 780     


<210> 6
<211> 324
<212> PRT
<213> Homo sapiens

<400> 6
Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser 
1               5                   10                  15      


Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu 
            20                  25                  30          


Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp 
        35                  40                  45              


Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu 
    50                  55                  60                  


Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His 
65                  70                  75                  80  


Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His 
                85                  90                  95      


Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg Gly 
            100                 105                 110         


Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg 
        115                 120                 125             


Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser Lys 
    130                 135                 140                 


Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val Asn 
145                 150                 155                 160 


His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr Val 
                165                 170                 175     


Thr Ser Ala Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr 
            180                 185                 190         


Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met Arg 
        195                 200                 205             


Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala 
    210                 215                 220                 


Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala 
225                 230                 235                 240 


Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp Leu 
                245                 250                 255     


His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln Pro 
            260                 265                 270         


Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu Val 
        275                 280                 285             


Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala Val 
    290                 295                 300                 


His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser Val 
305                 310                 315                 320 


Asn Pro Gly Lys 
                


<210> 7
<211> 331
<212> PRT
<213> Mus sp.

<400> 7
Val Arg Pro Val Asn Ile Thr Glu Pro Thr Leu Glu Leu Leu His Ser 
1               5                   10                  15      


Ser Cys Asp Pro Asn Ala Phe His Ser Thr Ile Gln Leu Tyr Cys Phe 
            20                  25                  30          


Ile Tyr Gly His Ile Leu Asn Asp Val Ser Val Ser Trp Leu Met Asp 
        35                  40                  45              


Asp Arg Glu Ile Thr Asp Thr Leu Ala Gln Thr Val Leu Ile Lys Glu 
    50                  55                  60                  


Glu Gly Lys Leu Ala Ser Thr Cys Ser Lys Leu Asn Ile Thr Glu Gln 
65                  70                  75                  80  


Gln Trp Met Ser Glu Ser Thr Phe Thr Cys Lys Val Thr Ser Gln Gly 
                85                  90                  95      


Val Asp Tyr Leu Ala His Thr Arg Arg Cys Pro Asp His Glu Pro Arg 
            100                 105                 110         


Gly Val Ile Thr Tyr Leu Ile Pro Pro Ser Pro Leu Asp Leu Tyr Gln 
        115                 120                 125             


Asn Gly Ala Pro Lys Leu Thr Cys Leu Val Val Asp Leu Glu Ser Glu 
    130                 135                 140                 


Lys Asn Val Asn Val Thr Trp Asn Gln Glu Lys Lys Thr Ser Val Ser 
145                 150                 155                 160 


Ala Ser Gln Trp Tyr Thr Lys His His Asn Asn Ala Thr Thr Ser Ile 
                165                 170                 175     


Thr Ser Ile Leu Pro Val Val Ala Lys Asp Trp Ile Glu Gly Tyr Gly 
            180                 185                 190         


Tyr Gln Cys Ile Val Asp His Pro Asp Phe Pro Lys Pro Ile Val Arg 
        195                 200                 205             


Ser Ile Thr Lys Thr Pro Gly Gln Arg Ser Ala Pro Glu Val Tyr Val 
    210                 215                 220                 


Phe Pro Pro Pro Glu Glu Glu Ser Glu Asp Lys Arg Thr Leu Thr Cys 
225                 230                 235                 240 


Leu Ile Gln Asn Phe Phe Pro Glu Asp Ile Ser Val Gln Trp Leu Gly 
                245                 250                 255     


Asp Gly Lys Leu Ile Ser Asn Ser Gln His Ser Thr Thr Thr Pro Leu 
            260                 265                 270         


Lys Ser Asn Gly Ser Asn Gln Gly Phe Phe Ile Phe Ser Arg Leu Glu 
        275                 280                 285             


Val Ala Lys Thr Leu Trp Thr Gln Arg Lys Gln Phe Thr Cys Gln Val 
    290                 295                 300                 


Ile His Glu Ala Leu Gln Lys Pro Arg Lys Leu Glu Lys Thr Ile Ser 
305                 310                 315                 320 


Thr Ser Leu Gly Asn Thr Ser Leu Arg Pro Ser 
                325                 330     


<210> 8
<211> 327
<212> PRT
<213> Canis lupus familiaris

<400> 8
Cys Ala Leu Asn Phe Ile Pro Pro Thr Val Lys Leu Phe His Ser Ser 
1               5                   10                  15      


Cys Asn Pro Val Gly Asp Thr His Thr Thr Ile Gln Leu Leu Cys Leu 
            20                  25                  30          


Ile Ser Gly Tyr Val Pro Gly Asp Met Glu Val Ile Trp Leu Val Asp 
        35                  40                  45              


Gly Gln Lys Ala Thr Asn Ile Phe Pro Tyr Thr Ala Pro Gly Thr Lys 
    50                  55                  60                  


Glu Gly Asn Val Thr Ser Thr His Ser Glu Leu Asn Ile Thr Gln Gly 
65                  70                  75                  80  


Glu Trp Val Ser Gln Lys Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                85                  90                  95      


Phe Thr Phe Lys Asp Glu Ala Arg Lys Cys Ser Glu Ser Asp Pro Arg 
            100                 105                 110         


Gly Val Thr Ser Tyr Leu Ser Pro Pro Ser Pro Leu Asp Leu Tyr Val 
        115                 120                 125             


His Lys Ala Pro Lys Ile Thr Cys Leu Val Val Asp Leu Ala Thr Met 
    130                 135                 140                 


Glu Gly Met Asn Leu Thr Trp Tyr Arg Glu Ser Lys Glu Pro Val Asn 
145                 150                 155                 160 


Pro Gly Pro Leu Asn Lys Lys Asp His Phe Asn Gly Thr Ile Thr Val 
                165                 170                 175     


Thr Ser Thr Leu Pro Val Asn Thr Asn Asp Trp Ile Glu Gly Glu Thr 
            180                 185                 190         


Tyr Tyr Cys Arg Val Thr His Pro His Leu Pro Lys Asp Ile Val Arg 
        195                 200                 205             


Ser Ile Ala Lys Ala Pro Gly Lys Arg Ala Pro Pro Asp Val Tyr Leu 
    210                 215                 220                 


Phe Leu Pro Pro Glu Glu Glu Gln Gly Thr Lys Asp Arg Val Thr Leu 
225                 230                 235                 240 


Thr Cys Leu Ile Gln Asn Phe Phe Pro Ala Asp Ile Ser Val Gln Trp 
                245                 250                 255     


Leu Arg Asn Asp Ser Pro Ile Gln Thr Asp Gln Tyr Thr Thr Thr Gly 
            260                 265                 270         


Pro His Lys Val Ser Gly Ser Arg Pro Ala Phe Phe Ile Phe Ser Arg 
        275                 280                 285             


Leu Glu Val Ser Arg Val Asp Trp Glu Gln Lys Asn Lys Phe Thr Cys 
    290                 295                 300                 


Gln Val Val His Glu Ala Leu Ser Gly Ser Arg Ile Leu Gln Lys Trp 
305                 310                 315                 320 


Val Ser Lys Thr Pro Gly Lys 
                325         


<210> 9
<211> 327
<212> PRT
<213> Felis catus

<400> 9
Cys Thr Met Asn Phe Ile Pro Pro Thr Val Lys Leu Phe His Ser Ser 
1               5                   10                  15      


Cys Asn Pro Leu Gly Asp Thr Gly Ser Thr Ile Gln Leu Leu Cys Leu 
            20                  25                  30          


Ile Ser Gly Tyr Val Pro Gly Asp Met Glu Val Thr Trp Leu Val Asp 
        35                  40                  45              


Gly Gln Lys Ala Thr Asn Ile Phe Pro Tyr Thr Ala Pro Gly Lys Gln 
    50                  55                  60                  


Glu Gly Lys Val Thr Ser Thr His Ser Glu Leu Asn Ile Thr Gln Gly 
65                  70                  75                  80  


Glu Trp Val Ser Gln Lys Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                85                  90                  95      


Phe Thr Phe Glu Asp His Ala Arg Lys Cys Thr Glu Ser Asp Pro Arg 
            100                 105                 110         


Gly Val Ser Thr Tyr Leu Ser Pro Pro Ser Pro Leu Asp Leu Tyr Val 
        115                 120                 125             


His Lys Ser Pro Lys Ile Thr Cys Leu Val Val Asp Leu Ala Asn Thr 
    130                 135                 140                 


Asp Gly Met Ile Leu Thr Trp Ser Arg Glu Asn Gly Glu Ser Val His 
145                 150                 155                 160 


Pro Asp Pro Met Val Lys Lys Thr Gln Tyr Asn Gly Thr Ile Thr Val 
                165                 170                 175     


Thr Ser Thr Leu Pro Val Asp Ala Thr Asp Trp Val Glu Gly Glu Thr 
            180                 185                 190         


Tyr Gln Cys Lys Val Thr His Pro Asp Leu Pro Lys Asp Ile Val Arg 
        195                 200                 205             


Ser Ile Ala Lys Ala Pro Gly Arg Arg Phe Pro Pro Glu Val Tyr Val 
    210                 215                 220                 


Phe Leu Pro Pro Glu Gly Glu Pro Lys Thr Lys Asp Lys Val Thr Leu 
225                 230                 235                 240 


Thr Cys Leu Ile Gln Asn Phe Phe Pro Pro Asp Ile Ser Val Gln Trp 
                245                 250                 255     


Leu His Asn Asp Ser Pro Val Arg Thr Glu Gln Gln Ala Thr Thr Trp 
            260                 265                 270         


Pro His Lys Ala Thr Gly Pro Ser Pro Ala Phe Phe Val Phe Ser Arg 
        275                 280                 285             


Leu Glu Val Ser Arg Ala Asp Trp Glu Gln Arg Asp Val Phe Thr Cys 
    290                 295                 300                 


Gln Val Val His Glu Ala Leu Pro Gly Phe Arg Thr Leu Lys Lys Ser 
305                 310                 315                 320 


Val Ser Lys Asn Pro Gly Lys 
                325         


<210> 10
<211> 231
<212> PRT
<213> Homo sapiens

<400> 10
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 11
<211> 215
<212> PRT
<213> Homo sapiens

<400> 11
Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
1               5                   10                  15      


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            20                  25                  30          


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        35                  40                  45              


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    50                  55                  60                  


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
65                  70                  75                  80  


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                85                  90                  95      


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
            100                 105                 110         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        115                 120                 125             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    130                 135                 140                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
145                 150                 155                 160 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                165                 170                 175     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            180                 185                 190         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        195                 200                 205             


Leu Ser Leu Ser Pro Gly Lys 
    210                 215 


<210> 12
<211> 278
<212> PRT
<213> Homo sapiens

<400> 12
Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            20                  25                  30          


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
        35                  40                  45              


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu 
    50                  55                  60                  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        115                 120                 125             


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
145                 150                 155                 160 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr 
    210                 215                 220                 


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Pro Gly Lys 
        275             


<210> 13
<211> 210
<212> PRT
<213> Homo sapiens

<400> 13
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu 
    210 


<210> 14
<211> 227
<212> PRT
<213> Mus sp.

<400> 14
Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
1               5                   10                  15      


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            20                  25                  30          


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        35                  40                  45              


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    50                  55                  60                  


His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr Phe 
65                  70                  75                  80  


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        115                 120                 125             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    130                 135                 140                 


Leu Thr Cys Met Ile Thr Asn Phe Phe Pro Glu Asp Ile Thr Val Glu 
145                 150                 155                 160 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                165                 170                 175     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            180                 185                 190         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        195                 200                 205             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 15
<211> 233
<212> PRT
<213> Mus sp.

<400> 15
Met Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             


<210> 16
<211> 239
<212> PRT
<213> Mus sp.

<400> 16
Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys 
1               5                   10                  15      


Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu Thr 
        35                  40                  45              


Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    50                  55                  60                  


Val Arg Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
65                  70                  75                  80  


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser 
                85                  90                  95      


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            100                 105                 110         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile 
        115                 120                 125             


Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu Pro 
    130                 135                 140                 


Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys Leu 
145                 150                 155                 160 


Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser Asn 
                165                 170                 175     


Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asp Ile Lys Thr Ser Lys 
        195                 200                 205             


Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly Leu 
    210                 215                 220                 


Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly Lys 
225                 230                 235                 


<210> 17
<211> 233
<212> PRT
<213> Mus sp.

<400> 17
Glu Pro Arg Ile Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Cys Pro 
1               5                   10                  15      


Pro Gly Asn Ile Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Ala Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val His Val Ser Trp Phe 
    50                  55                  60                  


Val Asp Asn Lys Glu Val His Thr Ala Trp Thr Gln Pro Arg Glu Ala 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Arg Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Arg 
        115                 120                 125             


Ala Gln Thr Pro Gln Val Tyr Thr Ile Pro Pro Pro Arg Glu Gln Met 
    130                 135                 140                 


Ser Lys Lys Lys Val Ser Leu Thr Cys Leu Val Thr Asn Phe Phe Ser 
145                 150                 155                 160 


Glu Ala Ile Ser Val Glu Trp Glu Arg Asn Gly Glu Leu Glu Gln Asp 
                165                 170                 175     


Tyr Lys Asn Thr Pro Pro Ile Leu Asp Ser Asp Gly Thr Tyr Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Thr Asp Ser Trp Leu Gln Gly Glu Ile 
        195                 200                 205             


Phe Thr Cys Ser Val Val His Glu Ala Leu His Asn His His Thr Gln 
    210                 215                 220                 


Lys Asn Leu Ser Arg Ser Pro Gly Lys 
225                 230             


<210> 18
<211> 224
<212> PRT
<213> Canis lupus familiaris

<400> 18
Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile 
1               5                   10                  15      


Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu 
            20                  25                  30          


Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln 
        35                  40                  45              


Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln 
    50                  55                  60                  


Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 
65                  70                  75                  80  


Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg 
                85                  90                  95      


Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
            100                 105                 110         


Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser 
        115                 120                 125             


Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile 
    130                 135                 140                 


Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
145                 150                 155                 160 


Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp 
                165                 170                 175     


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr 
        195                 200                 205             


Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220                 


<210> 19
<211> 223
<212> PRT
<213> Felis catus

<400> 19
Pro Lys Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile 
1               5                   10                  15      


Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu 
            20                  25                  30          


Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln 
        35                  40                  45              


Ile Thr Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser 
    50                  55                  60                  


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
65                  70                  75                  80  


Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys 
                85                  90                  95      


Val Asn Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
            100                 105                 110         


Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala 
        115                 120                 125             


Gln Glu Glu Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu Ile Lys 
    130                 135                 140                 


Ser Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln 
145                 150                 155                 160 


Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser 
                165                 170                 175     


Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His 
            180                 185                 190         


Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu 
        195                 200                 205             


His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
    210                 215                 220             


<210> 20
<211> 732
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Ala Gln Trp Lys Leu Glu Asn Asp Phe 
            20                  25                  30          


Gly Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu Leu Trp Val Ser 
        35                  40                  45              


Gly Arg Gln Ile Gly Ser Val Asp Thr Phe Arg Ile Pro Leu Ile Thr 
    50                  55                  60                  


Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala Arg Lys Met 
65                  70                  75                  80  


Ser Ser Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu Arg Arg Ser Met 
                85                  90                  95      


Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile Val Asn Asp Gly 
            100                 105                 110         


Asp Val Pro Asp Gly Leu Asn Leu Gly Ala Val Val Ser Asp Val Glu 
        115                 120                 125             


Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala His Lys Ala Gly 
    130                 135                 140                 


Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys Asp Asp Gly Val 
145                 150                 155                 160 


Ser Trp Ser Thr Pro Arg Asn Leu Ser Leu Asp Ile Gly Thr Glu Val 
                165                 170                 175     


Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln Arg Glu Pro Arg 
            180                 185                 190         


Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu Glu Arg Asp Gly 
        195                 200                 205             


Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser Trp Arg Tyr Gly 
    210                 215                 220                 


Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys Gln Glu Asn Asp 
225                 230                 235                 240 


Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp Gly Ser Val 
                245                 250                 255     


Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys His Cys Arg Ile 
            260                 265                 270         


Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg Pro Arg Asp Val 
        275                 280                 285             


Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala Ala Gly Ala Val 
    290                 295                 300                 


Val Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro Ala His Pro Glu 
305                 310                 315                 320 


Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn Gly Thr Ser 
                325                 330                 335     


Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro Ser Gly Tyr Ser 
            340                 345                 350         


Ser Leu Ala Thr Leu Glu Gly Ser Met Asp Gly Glu Glu Gln Ala Pro 
        355                 360                 365             


Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn His Tyr Thr Glu Ser 
    370                 375                 380                 


Ile Ser Val Ala Lys Ile Ser Val Tyr Gly Thr Leu Gly Gly Gly Gly 
385                 390                 395                 400 


Gly Gly Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln 
                405                 410                 415     


Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu 
            420                 425                 430         


Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu 
        435                 440                 445             


Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr 
    450                 455                 460                 


Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln 
465                 470                 475                 480 


Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln 
                485                 490                 495     


Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro 
            500                 505                 510         


Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe 
        515                 520                 525             


Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro 
    530                 535                 540                 


Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro 
545                 550                 555                 560 


Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu 
                565                 570                 575     


Thr Val Thr Ser Ala Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly 
            580                 585                 590         


Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu 
        595                 600                 605             


Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val 
    610                 615                 620                 


Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr 
625                 630                 635                 640 


Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln 
                645                 650                 655     


Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr 
            660                 665                 670         


Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu 
        675                 680                 685             


Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg 
    690                 695                 700                 


Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val 
705                 710                 715                 720 


Ser Val Asn Pro Gly Lys His His His His His His 
                725                 730         


<210> 21
<211> 724
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile 
            20                  25                  30          


Leu Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln 
        35                  40                  45              


Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr 
    50                  55                  60                  


Trp Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser 
65                  70                  75                  80  


Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu 
                85                  90                  95      


Ser Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr 
            100                 105                 110         


Tyr Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser 
        115                 120                 125             


Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp 
    130                 135                 140                 


Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu 
145                 150                 155                 160 


Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly 
                165                 170                 175     


Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly 
            180                 185                 190         


Thr Leu Thr Val Thr Ser Ala Leu Pro Val Gly Thr Arg Asp Trp Ile 
        195                 200                 205             


Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg 
    210                 215                 220                 


Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro 
225                 230                 235                 240 


Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys 
                245                 250                 255     


Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser 
            260                 265                 270         


Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser 
        275                 280                 285             


Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser 
    290                 295                 300                 


Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile 
305                 310                 315                 320 


Cys Arg Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg 
                325                 330                 335     


Ala Val Ser Val Asn Pro Gly Lys Met Ala Ser Leu Pro Val Leu Gln 
            340                 345                 350         


Lys Glu Ser Val Phe Gln Ser Gly Ala His Ala Tyr Arg Ile Pro Ala 
        355                 360                 365             


Leu Leu Tyr Leu Pro Gly Gln Gln Ser Leu Leu Ala Phe Ala Glu Gln 
    370                 375                 380                 


Arg Ala Ser Lys Lys Asp Glu His Ala Glu Leu Ile Val Leu Arg Arg 
385                 390                 395                 400 


Gly Asp Tyr Asp Ala Pro Thr His Gln Val Gln Trp Gln Ala Gln Glu 
                405                 410                 415     


Val Val Ala Gln Ala Arg Leu Asp Gly His Arg Ser Met Asn Pro Cys 
            420                 425                 430         


Pro Leu Tyr Asp Ala Gln Thr Gly Thr Leu Phe Leu Phe Phe Ile Ala 
        435                 440                 445             


Ile Pro Gly Gln Val Thr Glu Gln Gln Gln Leu Gln Thr Arg Ala Asn 
    450                 455                 460                 


Val Thr Arg Leu Cys Gln Val Thr Ser Thr Asp His Gly Arg Thr Trp 
465                 470                 475                 480 


Ser Ser Pro Arg Asp Leu Thr Asp Ala Ala Ile Gly Pro Ala Tyr Arg 
                485                 490                 495     


Glu Trp Ser Thr Phe Ala Val Gly Pro Gly His Cys Leu Gln Leu His 
            500                 505                 510         


Asp Arg Ala Arg Ser Leu Val Val Pro Ala Tyr Ala Tyr Arg Lys Leu 
        515                 520                 525             


His Pro Ile Gln Arg Pro Ile Pro Ser Ala Phe Cys Phe Leu Ser His 
    530                 535                 540                 


Asp His Gly Arg Thr Trp Ala Arg Gly His Phe Val Ala Gln Asp Thr 
545                 550                 555                 560 


Leu Glu Cys Gln Val Ala Glu Val Glu Thr Gly Glu Gln Arg Val Val 
                565                 570                 575     


Thr Leu Asn Ala Arg Ser His Leu Arg Ala Arg Val Gln Ala Gln Ser 
            580                 585                 590         


Thr Asn Asp Gly Leu Asp Phe Gln Glu Ser Gln Leu Val Lys Lys Leu 
        595                 600                 605             


Val Glu Pro Pro Pro Gln Gly Cys Gln Gly Ser Val Ile Ser Phe Pro 
    610                 615                 620                 


Ser Pro Arg Ser Gly Pro Gly Ser Pro Ala Gln Trp Leu Leu Tyr Thr 
625                 630                 635                 640 


His Pro Thr His Ser Trp Gln Arg Ala Asp Leu Gly Ala Tyr Leu Asn 
                645                 650                 655     


Pro Arg Pro Pro Ala Pro Glu Ala Trp Ser Glu Pro Val Leu Leu Ala 
            660                 665                 670         


Lys Gly Ser Cys Ala Tyr Ser Asp Leu Gln Ser Met Gly Thr Gly Pro 
        675                 680                 685             


Asp Gly Ser Pro Leu Phe Gly Cys Leu Tyr Glu Ala Asn Asp Tyr Glu 
    690                 695                 700                 


Glu Ile Val Phe Leu Met Phe Thr Leu Lys Gln Ala Phe Pro Ala Glu 
705                 710                 715                 720 


Tyr Leu Pro Gln 
                


<210> 22
<211> 731
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Ala Ser Leu Pro Val Leu Gln Lys Glu Ser Val Phe Gln Ser Gly Ala 
            20                  25                  30          


His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln Ser 
        35                  40                  45              


Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His Ala 
    50                  55                  60                  


Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His Gln 
65                  70                  75                  80  


Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp Gly 
                85                  90                  95      


His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly Thr 
            100                 105                 110         


Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln Gln 
        115                 120                 125             


Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr Ser 
    130                 135                 140                 


Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp Ala 
145                 150                 155                 160 


Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly Pro 
                165                 170                 175     


Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val Pro 
            180                 185                 190         


Ala Tyr Ala Tyr Arg Lys Leu His Pro Ile Gln Arg Pro Ile Pro Ser 
        195                 200                 205             


Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg Gly 
    210                 215                 220                 


His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Glu 
225                 230                 235                 240 


Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu Arg 
                245                 250                 255     


Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln Glu 
            260                 265                 270         


Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys Gln 
        275                 280                 285             


Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser Pro 
    290                 295                 300                 


Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg Ala 
305                 310                 315                 320 


Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala Trp 
                325                 330                 335     


Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp Leu 
            340                 345                 350         


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys Leu 
        355                 360                 365             


Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr Leu 
    370                 375                 380                 


Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly Gly 
385                 390                 395                 400 


Gly Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
                405                 410                 415     


Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
            420                 425                 430         


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
        435                 440                 445             


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
    450                 455                 460                 


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
465                 470                 475                 480 


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                485                 490                 495     


His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg 
            500                 505                 510         


Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile 
        515                 520                 525             


Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser 
    530                 535                 540                 


Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val 
545                 550                 555                 560 


Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr 
                565                 570                 575     


Val Thr Ser Ala Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu 
            580                 585                 590         


Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met 
        595                 600                 605             


Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr 
    610                 615                 620                 


Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu 
625                 630                 635                 640 


Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp 
                645                 650                 655     


Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln 
            660                 665                 670         


Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu 
        675                 680                 685             


Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala 
    690                 695                 700                 


Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser 
705                 710                 715                 720 


Val Asn Pro Gly Lys His His His His His His 
                725                 730     


<210> 23
<211> 813
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
            20                  25                  30          


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Glu 
        35                  40                  45              


Val Met Glu Glu Val Thr Thr Cys Ser Phe Asn Ser Pro Leu Phe Arg 
    50                  55                  60                  


Gln Glu Asp Asp Arg Gly Ile Thr Tyr Arg Ile Pro Ala Leu Leu Tyr 
65                  70                  75                  80  


Ile Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr 
                85                  90                  95      


Arg Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg 
            100                 105                 110         


Ile Gly Gln Leu Val Gln Trp Gly Pro Leu Lys Pro Leu Met Glu Ala 
        115                 120                 125             


Thr Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Gln 
    130                 135                 140                 


Lys Ser Gly Cys Val Phe Leu Phe Phe Ile Cys Val Arg Gly His Val 
145                 150                 155                 160 


Thr Glu Arg Gln Gln Ile Val Ser Gly Arg Asn Ala Ala Arg Leu Cys 
                165                 170                 175     


Phe Ile Tyr Ser Gln Asp Ala Gly Cys Ser Trp Ser Glu Val Arg Asp 
            180                 185                 190         


Leu Thr Glu Glu Val Ile Gly Ser Glu Leu Lys His Trp Ala Thr Phe 
        195                 200                 205             


Ala Val Gly Pro Gly His Gly Ile Gln Leu Gln Ser Gly Arg Leu Val 
    210                 215                 220                 


Ile Pro Ala Tyr Thr Tyr Tyr Ile Pro Ser Trp Phe Phe Cys Phe Gln 
225                 230                 235                 240 


Leu Pro Cys Lys Thr Arg Pro His Ser Leu Met Ile Tyr Ser Asp Asp 
                245                 250                 255     


Leu Gly Val Thr Trp His His Gly Arg Leu Ile Arg Pro Met Val Thr 
            260                 265                 270         


Val Glu Cys Glu Val Ala Glu Val Thr Gly Arg Ala Gly His Pro Val 
        275                 280                 285             


Leu Tyr Cys Ser Ala Arg Thr Pro Asn Arg Cys Arg Ala Glu Ala Leu 
    290                 295                 300                 


Ser Thr Asp His Gly Glu Gly Phe Gln Arg Leu Ala Leu Ser Arg Gln 
305                 310                 315                 320 


Leu Cys Glu Pro Pro His Gly Cys Gln Gly Ser Val Val Ser Phe Arg 
                325                 330                 335     


Pro Leu Glu Ile Pro His Arg Cys Gln Asp Ser Ser Ser Lys Asp Ala 
            340                 345                 350         


Pro Thr Ile Gln Gln Ser Ser Pro Gly Ser Ser Leu Arg Leu Glu Glu 
        355                 360                 365             


Glu Ala Gly Thr Pro Ser Glu Ser Trp Leu Leu Tyr Ser His Pro Thr 
    370                 375                 380                 


Ser Arg Lys Gln Arg Val Asp Leu Gly Ile Tyr Leu Asn Gln Thr Pro 
385                 390                 395                 400 


Leu Glu Ala Ala Cys Trp Ser Arg Pro Trp Ile Leu His Cys Gly Pro 
                405                 410                 415     


Cys Gly Tyr Ser Asp Leu Ala Ala Leu Glu Glu Glu Gly Leu Phe Gly 
            420                 425                 430         


Cys Leu Phe Glu Cys Gly Thr Lys Gln Glu Cys Glu Gln Ile Ala Phe 
        435                 440                 445             


Arg Leu Phe Thr His Arg Glu Ile Leu Ser His Leu Gln Gly Asp Cys 
    450                 455                 460                 


Thr Ser Pro Gly Arg Asn Pro Ser Gln Phe Lys Ser Asn Gly Gly Gly 
465                 470                 475                 480 


Gly Gly Gly Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu 
                485                 490                 495     


Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu 
            500                 505                 510         


Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp 
        515                 520                 525             


Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr 
    530                 535                 540                 


Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser 
545                 550                 555                 560 


Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr 
                565                 570                 575     


Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn 
            580                 585                 590         


Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu 
        595                 600                 605             


Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala 
    610                 615                 620                 


Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys 
625                 630                 635                 640 


Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr 
                645                 650                 655     


Leu Thr Val Thr Ser Ala Leu Pro Val Gly Thr Arg Asp Trp Ile Glu 
            660                 665                 670         


Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala 
        675                 680                 685             


Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu 
    690                 695                 700                 


Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg 
705                 710                 715                 720 


Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val 
                725                 730                 735     


Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr 
            740                 745                 750         


Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg 
        755                 760                 765             


Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys 
    770                 775                 780                 


Arg Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala 
785                 790                 795                 800 


Val Ser Val Asn Pro Gly Lys His His His His His His 
                805                 810             


<210> 24
<211> 836
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Gly Val Pro Arg Thr Pro Ser Arg Thr Val Leu Phe Glu Arg Glu 
            20                  25                  30          


Arg Thr Gly Leu Thr Tyr Arg Val Pro Ser Leu Leu Pro Val Pro Pro 
        35                  40                  45              


Gly Pro Thr Leu Leu Ala Phe Val Glu Gln Arg Leu Ser Pro Asp Asp 
    50                  55                  60                  


Ser His Ala His Arg Leu Val Leu Arg Arg Gly Thr Leu Ala Gly Gly 
65                  70                  75                  80  


Ser Val Arg Trp Gly Ala Leu His Val Leu Gly Thr Ala Ala Leu Ala 
                85                  90                  95      


Glu His Arg Ser Met Asn Pro Cys Pro Val His Asp Ala Gly Thr Gly 
            100                 105                 110         


Thr Val Phe Leu Phe Phe Ile Ala Val Leu Gly His Thr Pro Glu Ala 
        115                 120                 125             


Val Gln Ile Ala Thr Gly Arg Asn Ala Ala Arg Leu Cys Cys Val Ala 
    130                 135                 140                 


Ser Arg Asp Ala Gly Leu Ser Trp Gly Ser Ala Arg Asp Leu Thr Glu 
145                 150                 155                 160 


Glu Ala Ile Gly Gly Ala Val Gln Asp Trp Ala Thr Phe Ala Val Gly 
                165                 170                 175     


Pro Gly His Gly Val Gln Leu Pro Ser Gly Arg Leu Leu Val Pro Ala 
            180                 185                 190         


Tyr Thr Tyr Arg Val Asp Arg Arg Glu Cys Phe Gly Lys Ile Cys Arg 
        195                 200                 205             


Thr Ser Pro His Ser Phe Ala Phe Tyr Ser Asp Asp His Gly Arg Thr 
    210                 215                 220                 


Trp Arg Cys Gly Gly Leu Val Pro Asn Leu Arg Ser Gly Glu Cys Gln 
225                 230                 235                 240 


Leu Ala Ala Val Asp Gly Gly Gln Ala Gly Ser Phe Leu Tyr Cys Asn 
                245                 250                 255     


Ala Arg Ser Pro Leu Gly Ser Arg Val Gln Ala Leu Ser Thr Asp Glu 
            260                 265                 270         


Gly Thr Ser Phe Leu Pro Ala Glu Arg Val Ala Ser Leu Pro Glu Thr 
        275                 280                 285             


Ala Trp Gly Cys Gln Gly Ser Ile Val Gly Phe Pro Ala Pro Ala Pro 
    290                 295                 300                 


Asn Arg Pro Arg Asp Asp Ser Trp Ser Val Gly Pro Gly Ser Pro Leu 
305                 310                 315                 320 


Gln Pro Pro Leu Leu Gly Pro Gly Val His Glu Pro Pro Glu Glu Ala 
                325                 330                 335     


Ala Val Asp Pro Arg Gly Gly Gln Val Pro Gly Gly Pro Phe Ser Arg 
            340                 345                 350         


Leu Gln Pro Arg Gly Asp Gly Pro Arg Gln Pro Gly Pro Arg Pro Gly 
        355                 360                 365             


Val Ser Gly Asp Val Gly Ser Trp Thr Leu Ala Leu Pro Met Pro Phe 
    370                 375                 380                 


Ala Ala Pro Pro Gln Ser Pro Thr Trp Leu Leu Tyr Ser His Pro Val 
385                 390                 395                 400 


Gly Arg Arg Ala Arg Leu His Met Gly Ile Arg Leu Ser Gln Ser Pro 
                405                 410                 415     


Leu Asp Pro Arg Ser Trp Thr Glu Pro Trp Val Ile Tyr Glu Gly Pro 
            420                 425                 430         


Ser Gly Tyr Ser Asp Leu Ala Ser Ile Gly Pro Ala Pro Glu Gly Gly 
        435                 440                 445             


Leu Val Phe Ala Cys Leu Tyr Glu Ser Gly Ala Arg Thr Ser Tyr Asp 
    450                 455                 460                 


Glu Ile Ser Phe Cys Thr Phe Ser Leu Arg Glu Val Leu Glu Asn Val 
465                 470                 475                 480 


Pro Ala Ser Pro Lys Pro Pro Asn Leu Gly Asp Lys Pro Arg Gly Cys 
                485                 490                 495     


Cys Trp Pro Ser Gly Gly Gly Gly Gly Gly Cys Ser Arg Asp Phe Thr 
            500                 505                 510         


Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly Gly Gly His 
        515                 520                 525             


Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro 
    530                 535                 540                 


Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val Met Asp Val 
545                 550                 555                 560 


Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr 
                565                 570                 575     


Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser Asp Arg Thr 
            580                 585                 590         


Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu Asp Ser Thr 
        595                 600                 605             


Lys Lys Cys Ala Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser 
    610                 615                 620                 


Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr 
625                 630                 635                 640 


Cys Leu Val Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr 
                645                 650                 655     


Trp Ser Arg Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu 
            660                 665                 670         


Glu Lys Gln Arg Asn Gly Thr Leu Thr Val Thr Ser Ala Leu Pro Val 
        675                 680                 685             


Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr 
    690                 695                 700                 


His Pro His Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
705                 710                 715                 720 


Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
                725                 730                 735     


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
            740                 745                 750         


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
        755                 760                 765             


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
    770                 775                 780                 


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
785                 790                 795                 800 


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
                805                 810                 815     


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys His His 
            820                 825                 830         


His His His His 
        835     


<210> 25
<211> 1125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile 
            20                  25                  30          


Leu Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln 
        35                  40                  45              


Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr 
    50                  55                  60                  


Trp Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser 
65                  70                  75                  80  


Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu 
                85                  90                  95      


Ser Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr 
            100                 105                 110         


Tyr Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser 
        115                 120                 125             


Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp 
    130                 135                 140                 


Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu 
145                 150                 155                 160 


Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly 
                165                 170                 175     


Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly 
            180                 185                 190         


Thr Leu Thr Val Thr Ser Ala Leu Pro Val Gly Thr Arg Asp Trp Ile 
        195                 200                 205             


Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg 
    210                 215                 220                 


Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro 
225                 230                 235                 240 


Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys 
                245                 250                 255     


Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser 
            260                 265                 270         


Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser 
        275                 280                 285             


Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser 
    290                 295                 300                 


Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile 
305                 310                 315                 320 


Cys Arg Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg 
                325                 330                 335     


Ala Val Ser Val Asn Pro Gly Lys Met Arg Phe Lys Asn Val Lys Lys 
            340                 345                 350         


Thr Ala Leu Met Leu Ala Met Phe Gly Met Ala Thr Ser Ser Asn Ala 
        355                 360                 365             


Ala Leu Phe Asp Tyr Asn Ala Thr Gly Asp Thr Glu Phe Asp Ser Pro 
    370                 375                 380                 


Ala Lys Gln Gly Trp Met Gln Asp Asn Thr Asn Asn Gly Ser Gly Val 
385                 390                 395                 400 


Leu Thr Asn Ala Asp Gly Met Pro Ala Trp Leu Val Gln Gly Ile Gly 
                405                 410                 415     


Gly Arg Ala Gln Trp Thr Tyr Ser Leu Ser Thr Asn Gln His Ala Gln 
            420                 425                 430         


Ala Ser Ser Phe Gly Trp Arg Met Thr Thr Glu Met Lys Val Leu Ser 
        435                 440                 445             


Gly Gly Met Ile Thr Asn Tyr Tyr Ala Asn Gly Thr Gln Arg Val Leu 
    450                 455                 460                 


Pro Ile Ile Ser Leu Asp Ser Ser Gly Asn Leu Val Val Glu Phe Glu 
465                 470                 475                 480 


Gly Gln Thr Gly Arg Thr Val Leu Ala Thr Gly Thr Ala Ala Thr Glu 
                485                 490                 495     


Tyr His Lys Phe Glu Leu Val Phe Leu Pro Gly Ser Asn Pro Ser Ala 
            500                 505                 510         


Ser Phe Tyr Phe Asp Gly Lys Leu Ile Arg Asp Asn Ile Gln Pro Thr 
        515                 520                 525             


Ala Ser Lys Gln Asn Met Ile Val Trp Gly Asn Gly Ser Ser Asn Thr 
    530                 535                 540                 


Asp Gly Val Ala Ala Tyr Arg Asp Ile Lys Phe Glu Ile Gln Gly Asp 
545                 550                 555                 560 


Val Ile Phe Arg Gly Pro Asp Arg Ile Pro Ser Ile Val Ala Ser Ser 
                565                 570                 575     


Val Thr Pro Gly Val Val Thr Ala Phe Ala Glu Lys Arg Val Gly Gly 
            580                 585                 590         


Gly Asp Pro Gly Ala Leu Ser Asn Thr Asn Asp Ile Ile Thr Arg Thr 
        595                 600                 605             


Ser Arg Asp Gly Gly Ile Thr Trp Asp Thr Glu Leu Asn Leu Thr Glu 
    610                 615                 620                 


Gln Ile Asn Val Ser Asp Glu Phe Asp Phe Ser Asp Pro Arg Pro Ile 
625                 630                 635                 640 


Tyr Asp Pro Ser Ser Asn Thr Val Leu Val Ser Tyr Ala Arg Trp Pro 
                645                 650                 655     


Thr Asp Ala Ala Gln Asn Gly Asp Arg Ile Lys Pro Trp Met Pro Asn 
            660                 665                 670         


Gly Ile Phe Tyr Ser Val Tyr Asp Val Ala Ser Gly Asn Trp Gln Ala 
        675                 680                 685             


Pro Ile Asp Val Thr Asp Gln Val Lys Glu Arg Ser Phe Gln Ile Ala 
    690                 695                 700                 


Gly Trp Gly Gly Ser Glu Leu Tyr Arg Arg Asn Thr Ser Leu Asn Ser 
705                 710                 715                 720 


Gln Gln Asp Trp Gln Ser Asn Ala Lys Ile Arg Ile Val Asp Gly Ala 
                725                 730                 735     


Ala Asn Gln Ile Gln Val Ala Asp Gly Ser Arg Lys Tyr Val Val Thr 
            740                 745                 750         


Leu Ser Ile Asp Glu Ser Gly Gly Leu Val Ala Asn Leu Asn Gly Val 
        755                 760                 765             


Ser Ala Pro Ile Ile Leu Gln Ser Glu His Ala Lys Val His Ser Phe 
    770                 775                 780                 


His Asp Tyr Glu Leu Gln Tyr Ser Ala Leu Asn His Thr Thr Thr Leu 
785                 790                 795                 800 


Phe Val Asp Gly Gln Gln Ile Thr Thr Trp Ala Gly Glu Val Ser Gln 
                805                 810                 815     


Glu Asn Asn Ile Gln Phe Gly Asn Ala Asp Ala Gln Ile Asp Gly Arg 
            820                 825                 830         


Leu His Val Gln Lys Ile Val Leu Thr Gln Gln Gly His Asn Leu Val 
        835                 840                 845             


Glu Phe Asp Ala Phe Tyr Leu Ala Gln Gln Thr Pro Glu Val Glu Lys 
    850                 855                 860                 


Asp Leu Glu Lys Leu Gly Trp Thr Lys Ile Lys Thr Gly Asn Thr Met 
865                 870                 875                 880 


Ser Leu Tyr Gly Asn Ala Ser Val Asn Pro Gly Pro Gly His Gly Ile 
                885                 890                 895     


Thr Leu Thr Arg Gln Gln Asn Ile Ser Gly Ser Gln Asn Gly Arg Leu 
            900                 905                 910         


Ile Tyr Pro Ala Ile Val Leu Asp Arg Phe Phe Leu Asn Val Met Ser 
        915                 920                 925             


Ile Tyr Ser Asp Asp Gly Gly Ser Asn Trp Gln Thr Gly Ser Thr Leu 
    930                 935                 940                 


Pro Ile Pro Phe Arg Trp Lys Ser Ser Ser Ile Leu Glu Thr Leu Glu 
945                 950                 955                 960 


Pro Ser Glu Ala Asp Met Val Glu Leu Gln Asn Gly Asp Leu Leu Leu 
                965                 970                 975     


Thr Ala Arg Leu Asp Phe Asn Gln Ile Val Asn Gly Val Asn Tyr Ser 
            980                 985                 990         


Pro Arg Gln Gln Phe Leu Ser Lys  Asp Gly Gly Ile Thr  Trp Ser Leu 
        995                 1000                 1005             


Leu Glu  Ala Asn Asn Ala Asn  Val Phe Ser Asn Ile  Ser Thr Gly 
    1010                 1015                 1020             


Thr Val  Asp Ala Ser Ile Thr  Arg Phe Glu Gln Ser  Asp Gly Ser 
    1025                 1030                 1035             


His Phe  Leu Leu Phe Thr Asn  Pro Gln Gly Asn Pro  Ala Gly Thr 
    1040                 1045                 1050             


Asn Gly  Arg Gln Asn Leu Gly  Leu Trp Phe Ser Phe  Asp Glu Gly 
    1055                 1060                 1065             


Val Thr  Trp Lys Gly Pro Ile  Gln Leu Val Asn Gly  Ala Ser Ala 
    1070                 1075                 1080             


Tyr Ser  Asp Ile Tyr Gln Leu  Asp Ser Glu Asn Ala  Ile Val Ile 
    1085                 1090                 1095             


Val Glu  Thr Asp Asn Ser Asn  Met Arg Ile Leu Arg  Met Pro Ile 
    1100                 1105                 1110             


Thr Leu  Leu Lys Gln Lys Leu  Thr Leu Ser Gln Asn  
    1115                 1120                 1125 


<210> 26
<211> 739
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Ala Gln Trp Lys Leu Glu Asn Asp Phe 
            20                  25                  30          


Gly Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu Leu Trp Val Ser 
        35                  40                  45              


Gly Arg Gln Ile Gly Ser Val Asp Thr Phe Arg Ile Pro Leu Ile Thr 
    50                  55                  60                  


Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala Arg Lys Met 
65                  70                  75                  80  


Ser Ser Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu Arg Arg Ser Met 
                85                  90                  95      


Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile Val Asn Asp Gly 
            100                 105                 110         


Asp Val Pro Asp Gly Leu Asn Leu Gly Ala Val Val Ser Asp Val Glu 
        115                 120                 125             


Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala His Lys Ala Gly 
    130                 135                 140                 


Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys Asp Asp Gly Val 
145                 150                 155                 160 


Ser Trp Ser Thr Pro Arg Asn Leu Ser Leu Asp Ile Gly Thr Glu Val 
                165                 170                 175     


Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln Arg Glu Pro Arg 
            180                 185                 190         


Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu Glu Arg Asp Gly 
        195                 200                 205             


Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser Trp Arg Tyr Gly 
    210                 215                 220                 


Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys Gln Glu Asn Asp 
225                 230                 235                 240 


Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp Gly Ser Val 
                245                 250                 255     


Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys His Cys Arg Ile 
            260                 265                 270         


Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg Pro Arg Asp Val 
        275                 280                 285             


Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala Ala Gly Ala Val 
    290                 295                 300                 


Val Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro Ala His Pro Glu 
305                 310                 315                 320 


Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn Gly Thr Ser 
                325                 330                 335     


Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro Ser Gly Tyr Ser 
            340                 345                 350         


Ser Leu Ala Thr Leu Glu Gly Ser Met Asp Gly Glu Glu Gln Ala Pro 
        355                 360                 365             


Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn His Tyr Thr Glu Ser 
    370                 375                 380                 


Ile Ser Val Ala Lys Ile Ser Val Tyr Gly Thr Leu Gly Gly Gly Gly 
385                 390                 395                 400 


Gly Gly Val Arg Pro Val Asn Ile Thr Glu Pro Thr Leu Glu Leu Leu 
                405                 410                 415     


His Ser Ser Cys Asp Pro Asn Ala Phe His Ser Thr Ile Gln Leu Tyr 
            420                 425                 430         


Cys Phe Ile Tyr Gly His Ile Leu Asn Asp Val Ser Val Ser Trp Leu 
        435                 440                 445             


Met Asp Asp Arg Glu Ile Thr Asp Thr Leu Ala Gln Thr Val Leu Ile 
    450                 455                 460                 


Lys Glu Glu Gly Lys Leu Ala Ser Thr Cys Ser Lys Leu Asn Ile Thr 
465                 470                 475                 480 


Glu Gln Gln Trp Met Ser Glu Ser Thr Phe Thr Cys Lys Val Thr Ser 
                485                 490                 495     


Gln Gly Val Asp Tyr Leu Ala His Thr Arg Arg Cys Pro Asp His Glu 
            500                 505                 510         


Pro Arg Gly Val Ile Thr Tyr Leu Ile Pro Pro Ser Pro Leu Asp Leu 
        515                 520                 525             


Tyr Gln Asn Gly Ala Pro Lys Leu Thr Cys Leu Val Val Asp Leu Glu 
    530                 535                 540                 


Ser Glu Lys Asn Val Asn Val Thr Trp Asn Gln Glu Lys Lys Thr Ser 
545                 550                 555                 560 


Val Ser Ala Ser Gln Trp Tyr Thr Lys His His Asn Asn Ala Thr Thr 
                565                 570                 575     


Ser Ile Thr Ser Ile Leu Pro Val Val Ala Lys Asp Trp Ile Glu Gly 
            580                 585                 590         


Tyr Gly Tyr Gln Cys Ile Val Asp His Pro Asp Phe Pro Lys Pro Ile 
        595                 600                 605             


Val Arg Ser Ile Thr Lys Thr Pro Gly Gln Arg Ser Ala Pro Glu Val 
    610                 615                 620                 


Tyr Val Phe Pro Pro Pro Glu Glu Glu Ser Glu Asp Lys Arg Thr Leu 
625                 630                 635                 640 


Thr Cys Leu Ile Gln Asn Phe Phe Pro Glu Asp Ile Ser Val Gln Trp 
                645                 650                 655     


Leu Gly Asp Gly Lys Leu Ile Ser Asn Ser Gln His Ser Thr Thr Thr 
            660                 665                 670         


Pro Leu Lys Ser Asn Gly Ser Asn Gln Gly Phe Phe Ile Phe Ser Arg 
        675                 680                 685             


Leu Glu Val Ala Lys Thr Leu Trp Thr Gln Arg Lys Gln Phe Thr Cys 
    690                 695                 700                 


Gln Val Ile His Glu Ala Leu Gln Lys Pro Arg Lys Leu Glu Lys Thr 
705                 710                 715                 720 


Ile Ser Thr Ser Leu Gly Asn Thr Ser Leu Arg Pro Ser His His His 
                725                 730                 735     


His His His 
            


<210> 27
<211> 740
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Asp Met Ala Ser Leu Pro Val Leu Gln Lys Glu Ser Val Phe Gln Ser 
            20                  25                  30          


Gly Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln 
        35                  40                  45              


Gln Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu 
    50                  55                  60                  


His Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr 
65                  70                  75                  80  


His Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu 
                85                  90                  95      


Asp Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr 
            100                 105                 110         


Gly Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu 
        115                 120                 125             


Gln Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val 
    130                 135                 140                 


Thr Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr 
145                 150                 155                 160 


Asp Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val 
                165                 170                 175     


Gly Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val 
            180                 185                 190         


Val Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Ile Gln Arg Pro Ile 
        195                 200                 205             


Pro Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala 
    210                 215                 220                 


Arg Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu 
225                 230                 235                 240 


Val Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His 
                245                 250                 255     


Leu Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe 
            260                 265                 270         


Gln Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly 
        275                 280                 285             


Cys Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly 
    290                 295                 300                 


Ser Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln 
305                 310                 315                 320 


Arg Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu 
                325                 330                 335     


Ala Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser 
            340                 345                 350         


Asp Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly 
        355                 360                 365             


Cys Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe 
    370                 375                 380                 


Thr Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly 
385                 390                 395                 400 


Gly Gly Gly Val Arg Pro Val Asn Ile Thr Glu Pro Thr Leu Glu Leu 
                405                 410                 415     


Leu His Ser Ser Cys Asp Pro Asn Ala Phe His Ser Thr Ile Gln Leu 
            420                 425                 430         


Tyr Cys Phe Ile Tyr Gly His Ile Leu Asn Asp Val Ser Val Ser Trp 
        435                 440                 445             


Leu Met Asp Asp Arg Glu Ile Thr Asp Thr Leu Ala Gln Thr Val Leu 
    450                 455                 460                 


Ile Lys Glu Glu Gly Lys Leu Ala Ser Thr Cys Ser Lys Leu Asn Ile 
465                 470                 475                 480 


Thr Glu Gln Gln Trp Met Ser Glu Ser Thr Phe Thr Cys Lys Val Thr 
                485                 490                 495     


Ser Gln Gly Val Asp Tyr Leu Ala His Thr Arg Arg Cys Pro Asp His 
            500                 505                 510         


Glu Pro Arg Gly Val Ile Thr Tyr Leu Ile Pro Pro Ser Pro Leu Asp 
        515                 520                 525             


Leu Tyr Gln Asn Gly Ala Pro Lys Leu Thr Cys Leu Val Val Asp Leu 
    530                 535                 540                 


Glu Ser Glu Lys Asn Val Asn Val Thr Trp Asn Gln Glu Lys Lys Thr 
545                 550                 555                 560 


Ser Val Ser Ala Ser Gln Trp Tyr Thr Lys His His Asn Asn Ala Thr 
                565                 570                 575     


Thr Ser Ile Thr Ser Ile Leu Pro Val Val Ala Lys Asp Trp Ile Glu 
            580                 585                 590         


Gly Tyr Gly Tyr Gln Cys Ile Val Asp His Pro Asp Phe Pro Lys Pro 
        595                 600                 605             


Ile Val Arg Ser Ile Thr Lys Thr Pro Gly Gln Arg Ser Ala Pro Glu 
    610                 615                 620                 


Val Tyr Val Phe Pro Pro Pro Glu Glu Glu Ser Glu Asp Lys Arg Thr 
625                 630                 635                 640 


Leu Thr Cys Leu Ile Gln Asn Phe Phe Pro Glu Asp Ile Ser Val Gln 
                645                 650                 655     


Trp Leu Gly Asp Gly Lys Leu Ile Ser Asn Ser Gln His Ser Thr Thr 
            660                 665                 670         


Thr Pro Leu Lys Ser Asn Gly Ser Asn Gln Gly Phe Phe Ile Phe Ser 
        675                 680                 685             


Arg Leu Glu Val Ala Lys Thr Leu Trp Thr Gln Arg Lys Gln Phe Thr 
    690                 695                 700                 


Cys Gln Val Ile His Glu Ala Leu Gln Lys Pro Arg Lys Leu Glu Lys 
705                 710                 715                 720 


Thr Ile Ser Thr Ser Leu Gly Asn Thr Ser Leu Arg Pro Ser His His 
                725                 730                 735     


His His His His 
            740 


<210> 28
<211> 820
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
            20                  25                  30          


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Glu 
        35                  40                  45              


Val Met Glu Glu Val Thr Thr Cys Ser Phe Asn Ser Pro Leu Phe Arg 
    50                  55                  60                  


Gln Glu Asp Asp Arg Gly Ile Thr Tyr Arg Ile Pro Ala Leu Leu Tyr 
65                  70                  75                  80  


Ile Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr 
                85                  90                  95      


Arg Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg 
            100                 105                 110         


Ile Gly Gln Leu Val Gln Trp Gly Pro Leu Lys Pro Leu Met Glu Ala 
        115                 120                 125             


Thr Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Gln 
    130                 135                 140                 


Lys Ser Gly Cys Val Phe Leu Phe Phe Ile Cys Val Arg Gly His Val 
145                 150                 155                 160 


Thr Glu Arg Gln Gln Ile Val Ser Gly Arg Asn Ala Ala Arg Leu Cys 
                165                 170                 175     


Phe Ile Tyr Ser Gln Asp Ala Gly Cys Ser Trp Ser Glu Val Arg Asp 
            180                 185                 190         


Leu Thr Glu Glu Val Ile Gly Ser Glu Leu Lys His Trp Ala Thr Phe 
        195                 200                 205             


Ala Val Gly Pro Gly His Gly Ile Gln Leu Gln Ser Gly Arg Leu Val 
    210                 215                 220                 


Ile Pro Ala Tyr Thr Tyr Tyr Ile Pro Ser Trp Phe Phe Cys Phe Gln 
225                 230                 235                 240 


Leu Pro Cys Lys Thr Arg Pro His Ser Leu Met Ile Tyr Ser Asp Asp 
                245                 250                 255     


Leu Gly Val Thr Trp His His Gly Arg Leu Ile Arg Pro Met Val Thr 
            260                 265                 270         


Val Glu Cys Glu Val Ala Glu Val Thr Gly Arg Ala Gly His Pro Val 
        275                 280                 285             


Leu Tyr Cys Ser Ala Arg Thr Pro Asn Arg Cys Arg Ala Glu Ala Leu 
    290                 295                 300                 


Ser Thr Asp His Gly Glu Gly Phe Gln Arg Leu Ala Leu Ser Arg Gln 
305                 310                 315                 320 


Leu Cys Glu Pro Pro His Gly Cys Gln Gly Ser Val Val Ser Phe Arg 
                325                 330                 335     


Pro Leu Glu Ile Pro His Arg Cys Gln Asp Ser Ser Ser Lys Asp Ala 
            340                 345                 350         


Pro Thr Ile Gln Gln Ser Ser Pro Gly Ser Ser Leu Arg Leu Glu Glu 
        355                 360                 365             


Glu Ala Gly Thr Pro Ser Glu Ser Trp Leu Leu Tyr Ser His Pro Thr 
    370                 375                 380                 


Ser Arg Lys Gln Arg Val Asp Leu Gly Ile Tyr Leu Asn Gln Thr Pro 
385                 390                 395                 400 


Leu Glu Ala Ala Cys Trp Ser Arg Pro Trp Ile Leu His Cys Gly Pro 
                405                 410                 415     


Cys Gly Tyr Ser Asp Leu Ala Ala Leu Glu Glu Glu Gly Leu Phe Gly 
            420                 425                 430         


Cys Leu Phe Glu Cys Gly Thr Lys Gln Glu Cys Glu Gln Ile Ala Phe 
        435                 440                 445             


Arg Leu Phe Thr His Arg Glu Ile Leu Ser His Leu Gln Gly Asp Cys 
    450                 455                 460                 


Thr Ser Pro Gly Arg Asn Pro Ser Gln Phe Lys Ser Asn Gly Gly Gly 
465                 470                 475                 480 


Gly Gly Gly Val Arg Pro Val Asn Ile Thr Glu Pro Thr Leu Glu Leu 
                485                 490                 495     


Leu His Ser Ser Cys Asp Pro Asn Ala Phe His Ser Thr Ile Gln Leu 
            500                 505                 510         


Tyr Cys Phe Ile Tyr Gly His Ile Leu Asn Asp Val Ser Val Ser Trp 
        515                 520                 525             


Leu Met Asp Asp Arg Glu Ile Thr Asp Thr Leu Ala Gln Thr Val Leu 
    530                 535                 540                 


Ile Lys Glu Glu Gly Lys Leu Ala Ser Thr Cys Ser Lys Leu Asn Ile 
545                 550                 555                 560 


Thr Glu Gln Gln Trp Met Ser Glu Ser Thr Phe Thr Cys Lys Val Thr 
                565                 570                 575     


Ser Gln Gly Val Asp Tyr Leu Ala His Thr Arg Arg Cys Pro Asp His 
            580                 585                 590         


Glu Pro Arg Gly Val Ile Thr Tyr Leu Ile Pro Pro Ser Pro Leu Asp 
        595                 600                 605             


Leu Tyr Gln Asn Gly Ala Pro Lys Leu Thr Cys Leu Val Val Asp Leu 
    610                 615                 620                 


Glu Ser Glu Lys Asn Val Asn Val Thr Trp Asn Gln Glu Lys Lys Thr 
625                 630                 635                 640 


Ser Val Ser Ala Ser Gln Trp Tyr Thr Lys His His Asn Asn Ala Thr 
                645                 650                 655     


Thr Ser Ile Thr Ser Ile Leu Pro Val Val Ala Lys Asp Trp Ile Glu 
            660                 665                 670         


Gly Tyr Gly Tyr Gln Cys Ile Val Asp His Pro Asp Phe Pro Lys Pro 
        675                 680                 685             


Ile Val Arg Ser Ile Thr Lys Thr Pro Gly Gln Arg Ser Ala Pro Glu 
    690                 695                 700                 


Val Tyr Val Phe Pro Pro Pro Glu Glu Glu Ser Glu Asp Lys Arg Thr 
705                 710                 715                 720 


Leu Thr Cys Leu Ile Gln Asn Phe Phe Pro Glu Asp Ile Ser Val Gln 
                725                 730                 735     


Trp Leu Gly Asp Gly Lys Leu Ile Ser Asn Ser Gln His Ser Thr Thr 
            740                 745                 750         


Thr Pro Leu Lys Ser Asn Gly Ser Asn Gln Gly Phe Phe Ile Phe Ser 
        755                 760                 765             


Arg Leu Glu Val Ala Lys Thr Leu Trp Thr Gln Arg Lys Gln Phe Thr 
    770                 775                 780                 


Cys Gln Val Ile His Glu Ala Leu Gln Lys Pro Arg Lys Leu Glu Lys 
785                 790                 795                 800 


Thr Ile Ser Thr Ser Leu Gly Asn Thr Ser Leu Arg Pro Ser His His 
                805                 810                 815     


His His His His 
            820 


<210> 29
<211> 843
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Gly Val Pro Arg Thr Pro Ser Arg Thr Val Leu Phe Glu Arg Glu 
            20                  25                  30          


Arg Thr Gly Leu Thr Tyr Arg Val Pro Ser Leu Leu Pro Val Pro Pro 
        35                  40                  45              


Gly Pro Thr Leu Leu Ala Phe Val Glu Gln Arg Leu Ser Pro Asp Asp 
    50                  55                  60                  


Ser His Ala His Arg Leu Val Leu Arg Arg Gly Thr Leu Ala Gly Gly 
65                  70                  75                  80  


Ser Val Arg Trp Gly Ala Leu His Val Leu Gly Thr Ala Ala Leu Ala 
                85                  90                  95      


Glu His Arg Ser Met Asn Pro Cys Pro Val His Asp Ala Gly Thr Gly 
            100                 105                 110         


Thr Val Phe Leu Phe Phe Ile Ala Val Leu Gly His Thr Pro Glu Ala 
        115                 120                 125             


Val Gln Ile Ala Thr Gly Arg Asn Ala Ala Arg Leu Cys Cys Val Ala 
    130                 135                 140                 


Ser Arg Asp Ala Gly Leu Ser Trp Gly Ser Ala Arg Asp Leu Thr Glu 
145                 150                 155                 160 


Glu Ala Ile Gly Gly Ala Val Gln Asp Trp Ala Thr Phe Ala Val Gly 
                165                 170                 175     


Pro Gly His Gly Val Gln Leu Pro Ser Gly Arg Leu Leu Val Pro Ala 
            180                 185                 190         


Tyr Thr Tyr Arg Val Asp Arg Arg Glu Cys Phe Gly Lys Ile Cys Arg 
        195                 200                 205             


Thr Ser Pro His Ser Phe Ala Phe Tyr Ser Asp Asp His Gly Arg Thr 
    210                 215                 220                 


Trp Arg Cys Gly Gly Leu Val Pro Asn Leu Arg Ser Gly Glu Cys Gln 
225                 230                 235                 240 


Leu Ala Ala Val Asp Gly Gly Gln Ala Gly Ser Phe Leu Tyr Cys Asn 
                245                 250                 255     


Ala Arg Ser Pro Leu Gly Ser Arg Val Gln Ala Leu Ser Thr Asp Glu 
            260                 265                 270         


Gly Thr Ser Phe Leu Pro Ala Glu Arg Val Ala Ser Leu Pro Glu Thr 
        275                 280                 285             


Ala Trp Gly Cys Gln Gly Ser Ile Val Gly Phe Pro Ala Pro Ala Pro 
    290                 295                 300                 


Asn Arg Pro Arg Asp Asp Ser Trp Ser Val Gly Pro Gly Ser Pro Leu 
305                 310                 315                 320 


Gln Pro Pro Leu Leu Gly Pro Gly Val His Glu Pro Pro Glu Glu Ala 
                325                 330                 335     


Ala Val Asp Pro Arg Gly Gly Gln Val Pro Gly Gly Pro Phe Ser Arg 
            340                 345                 350         


Leu Gln Pro Arg Gly Asp Gly Pro Arg Gln Pro Gly Pro Arg Pro Gly 
        355                 360                 365             


Val Ser Gly Asp Val Gly Ser Trp Thr Leu Ala Leu Pro Met Pro Phe 
    370                 375                 380                 


Ala Ala Pro Pro Gln Ser Pro Thr Trp Leu Leu Tyr Ser His Pro Val 
385                 390                 395                 400 


Gly Arg Arg Ala Arg Leu His Met Gly Ile Arg Leu Ser Gln Ser Pro 
                405                 410                 415     


Leu Asp Pro Arg Ser Trp Thr Glu Pro Trp Val Ile Tyr Glu Gly Pro 
            420                 425                 430         


Ser Gly Tyr Ser Asp Leu Ala Ser Ile Gly Pro Ala Pro Glu Gly Gly 
        435                 440                 445             


Leu Val Phe Ala Cys Leu Tyr Glu Ser Gly Ala Arg Thr Ser Tyr Asp 
    450                 455                 460                 


Glu Ile Ser Phe Cys Thr Phe Ser Leu Arg Glu Val Leu Glu Asn Val 
465                 470                 475                 480 


Pro Ala Ser Pro Lys Pro Pro Asn Leu Gly Asp Lys Pro Arg Gly Cys 
                485                 490                 495     


Cys Trp Pro Ser Gly Gly Gly Gly Gly Gly Val Arg Pro Val Asn Ile 
            500                 505                 510         


Thr Glu Pro Thr Leu Glu Leu Leu His Ser Ser Cys Asp Pro Asn Ala 
        515                 520                 525             


Phe His Ser Thr Ile Gln Leu Tyr Cys Phe Ile Tyr Gly His Ile Leu 
    530                 535                 540                 


Asn Asp Val Ser Val Ser Trp Leu Met Asp Asp Arg Glu Ile Thr Asp 
545                 550                 555                 560 


Thr Leu Ala Gln Thr Val Leu Ile Lys Glu Glu Gly Lys Leu Ala Ser 
                565                 570                 575     


Thr Cys Ser Lys Leu Asn Ile Thr Glu Gln Gln Trp Met Ser Glu Ser 
            580                 585                 590         


Thr Phe Thr Cys Lys Val Thr Ser Gln Gly Val Asp Tyr Leu Ala His 
        595                 600                 605             


Thr Arg Arg Cys Pro Asp His Glu Pro Arg Gly Val Ile Thr Tyr Leu 
    610                 615                 620                 


Ile Pro Pro Ser Pro Leu Asp Leu Tyr Gln Asn Gly Ala Pro Lys Leu 
625                 630                 635                 640 


Thr Cys Leu Val Val Asp Leu Glu Ser Glu Lys Asn Val Asn Val Thr 
                645                 650                 655     


Trp Asn Gln Glu Lys Lys Thr Ser Val Ser Ala Ser Gln Trp Tyr Thr 
            660                 665                 670         


Lys His His Asn Asn Ala Thr Thr Ser Ile Thr Ser Ile Leu Pro Val 
        675                 680                 685             


Val Ala Lys Asp Trp Ile Glu Gly Tyr Gly Tyr Gln Cys Ile Val Asp 
    690                 695                 700                 


His Pro Asp Phe Pro Lys Pro Ile Val Arg Ser Ile Thr Lys Thr Pro 
705                 710                 715                 720 


Gly Gln Arg Ser Ala Pro Glu Val Tyr Val Phe Pro Pro Pro Glu Glu 
                725                 730                 735     


Glu Ser Glu Asp Lys Arg Thr Leu Thr Cys Leu Ile Gln Asn Phe Phe 
            740                 745                 750         


Pro Glu Asp Ile Ser Val Gln Trp Leu Gly Asp Gly Lys Leu Ile Ser 
        755                 760                 765             


Asn Ser Gln His Ser Thr Thr Thr Pro Leu Lys Ser Asn Gly Ser Asn 
    770                 775                 780                 


Gln Gly Phe Phe Ile Phe Ser Arg Leu Glu Val Ala Lys Thr Leu Trp 
785                 790                 795                 800 


Thr Gln Arg Lys Gln Phe Thr Cys Gln Val Ile His Glu Ala Leu Gln 
                805                 810                 815     


Lys Pro Arg Lys Leu Glu Lys Thr Ile Ser Thr Ser Leu Gly Asn Thr 
            820                 825                 830         


Ser Leu Arg Pro Ser His His His His His His 
        835                 840             


<210> 30
<211> 725
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Cys Ala Leu Asn Phe Ile Pro Pro Thr Val Lys Leu 
            20                  25                  30          


Phe His Ser Ser Cys Asn Pro Val Gly Asp Thr His Thr Thr Ile Gln 
        35                  40                  45              


Leu Leu Cys Leu Ile Ser Gly Tyr Val Pro Gly Asp Met Glu Val Ile 
    50                  55                  60                  


Trp Leu Val Asp Gly Gln Lys Ala Thr Asn Ile Phe Pro Tyr Thr Ala 
65                  70                  75                  80  


Pro Gly Thr Lys Glu Gly Asn Val Thr Ser Thr His Ser Glu Leu Asn 
                85                  90                  95      


Ile Thr Gln Gly Glu Trp Val Ser Gln Lys Thr Tyr Thr Cys Gln Val 
            100                 105                 110         


Thr Tyr Gln Gly Phe Thr Phe Lys Asp Glu Ala Arg Lys Cys Ser Glu 
        115                 120                 125             


Ser Asp Pro Arg Gly Val Thr Ser Tyr Leu Ser Pro Pro Ser Pro Leu 
    130                 135                 140                 


Asp Leu Tyr Val His Lys Ala Pro Lys Ile Thr Cys Leu Val Val Asp 
145                 150                 155                 160 


Leu Ala Thr Met Glu Gly Met Asn Leu Thr Trp Tyr Arg Glu Ser Lys 
                165                 170                 175     


Glu Pro Val Asn Pro Gly Pro Leu Asn Lys Lys Asp His Phe Asn Gly 
            180                 185                 190         


Thr Ile Thr Val Thr Ser Thr Leu Pro Val Asn Thr Asn Asp Trp Ile 
        195                 200                 205             


Glu Gly Glu Thr Tyr Tyr Cys Arg Val Thr His Pro His Leu Pro Lys 
    210                 215                 220                 


Asp Ile Val Arg Ser Ile Ala Lys Ala Pro Gly Lys Arg Ala Pro Pro 
225                 230                 235                 240 


Asp Val Tyr Leu Phe Leu Pro Pro Glu Glu Glu Gln Gly Thr Lys Asp 
                245                 250                 255     


Arg Val Thr Leu Thr Cys Leu Ile Gln Asn Phe Phe Pro Ala Asp Ile 
            260                 265                 270         


Ser Val Gln Trp Leu Arg Asn Asp Ser Pro Ile Gln Thr Asp Gln Tyr 
        275                 280                 285             


Thr Thr Thr Gly Pro His Lys Val Ser Gly Ser Arg Pro Ala Phe Phe 
    290                 295                 300                 


Ile Phe Ser Arg Leu Glu Val Ser Arg Val Asp Trp Glu Gln Lys Asn 
305                 310                 315                 320 


Lys Phe Thr Cys Gln Val Val His Glu Ala Leu Ser Gly Ser Arg Ile 
                325                 330                 335     


Leu Gln Lys Trp Val Ser Lys Thr Pro Gly Lys Met Ala Ser Cys Pro 
            340                 345                 350         


Val Leu Gln Lys Glu Lys Val Phe Gln Ser Gly Ala His Ala Tyr Arg 
        355                 360                 365             


Ile Pro Ala Leu Leu Tyr Leu Pro Gln Gln Lys Thr Leu Leu Ala Phe 
    370                 375                 380                 


Ala Glu Lys Arg Thr Ser Lys Lys Asp Glu His Ala Glu Leu Ile Val 
385                 390                 395                 400 


Leu Arg Arg Gly Ser Tyr Asp Ala Ser Thr His His Val Gln Trp His 
                405                 410                 415     


Ala Gln Glu Val Val Ala Gln Ala Gln Leu Glu Gly His Arg Ser Met 
            420                 425                 430         


Asn Pro Ser Pro Leu Tyr Asp Glu Lys Thr Gly Thr Leu Phe Leu Phe 
        435                 440                 445             


Phe Ile Ala Ile Pro Gly Gln Val Ser Glu His His Gln Leu His Thr 
    450                 455                 460                 


Arg Val Asn Val Thr Arg Leu Cys Gln Val Thr Ser Thr Asp His Gly 
465                 470                 475                 480 


Arg Ser Trp Ser Pro Ala Arg Asp Leu Thr Gly Pro Ala Ile Gly Ala 
                485                 490                 495     


Ala His Lys Glu Trp Ala Thr Phe Ala Val Gly Pro Gly His Cys Leu 
            500                 505                 510         


Gln Leu His Asn Lys Ala Gln Ser Leu Val Val Pro Ala Tyr Ala Tyr 
        515                 520                 525             


Arg Asn Leu His Ser Leu Pro Arg Pro Ser Pro Phe Ala Phe Cys Phe 
    530                 535                 540                 


Val Ser His Asp His Gly His Thr Trp Glu Arg Gly Asn Phe Val Ala 
545                 550                 555                 560 


Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Gly Gly Ala Glu Arg 
                565                 570                 575     


Arg Val Val Tyr Leu Asn Ala Arg Ser Pro Arg Arg Ala Arg Val Gln 
            580                 585                 590         


Ala Glu Ser Thr Asn Glu Gly Leu Asp Phe Thr Glu Ala Gln Val Val 
        595                 600                 605             


Lys Glu Leu Val Glu Pro Pro His Gly Cys Gln Gly Ser Val Ile Ser 
    610                 615                 620                 


Phe Pro Asn Pro His Ala Gly Ser Gly Ala Cys Asp Arg Trp Leu Leu 
625                 630                 635                 640 


Tyr Thr His Pro Thr Asp Pro Gln Arg Arg Ala His Leu Gly Ala Tyr 
                645                 650                 655     


Leu His Arg Arg Arg Pro Gly Arg Glu Ala Trp Ser Glu Pro Val Pro 
            660                 665                 670         


Leu Ala Ala Gly Gly Cys Ala Tyr Ser Asp Leu Gln Ala Met Gly Ala 
        675                 680                 685             


Gly Pro Asp Gly Ser Pro Gln Phe Gly Cys Leu Tyr Glu Ser Gly His 
    690                 695                 700                 


Tyr Glu Glu Val Val Phe Leu Met Phe Thr Leu Lys Gln Ala Phe Pro 
705                 710                 715                 720 


Ala Glu Phe Val Ser 
                725 


<210> 31
<211> 726
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Cys Thr Met Asn Phe Ile Pro Pro Thr Val Lys Leu 
            20                  25                  30          


Phe His Ser Ser Cys Asn Pro Leu Gly Asp Thr Gly Ser Thr Ile Gln 
        35                  40                  45              


Leu Leu Cys Leu Ile Ser Gly Tyr Val Pro Gly Asp Met Glu Val Thr 
    50                  55                  60                  


Trp Leu Val Asp Gly Gln Lys Ala Thr Asn Ile Phe Pro Tyr Thr Ala 
65                  70                  75                  80  


Pro Gly Lys Gln Glu Gly Lys Val Thr Ser Thr His Ser Glu Leu Asn 
                85                  90                  95      


Ile Thr Gln Gly Glu Trp Val Ser Gln Lys Thr Tyr Thr Cys Gln Val 
            100                 105                 110         


Thr Tyr Gln Gly Phe Thr Phe Glu Asp His Ala Arg Lys Cys Thr Glu 
        115                 120                 125             


Ser Asp Pro Arg Gly Val Ser Thr Tyr Leu Ser Pro Pro Ser Pro Leu 
    130                 135                 140                 


Asp Leu Tyr Val His Lys Ser Pro Lys Ile Thr Cys Leu Val Val Asp 
145                 150                 155                 160 


Leu Ala Asn Thr Asp Gly Met Ile Leu Thr Trp Ser Arg Glu Asn Gly 
                165                 170                 175     


Glu Ser Val His Pro Asp Pro Met Val Lys Lys Thr Gln Tyr Asn Gly 
            180                 185                 190         


Thr Ile Thr Val Thr Ser Thr Leu Pro Val Asp Ala Thr Asp Trp Val 
        195                 200                 205             


Glu Gly Glu Thr Tyr Gln Cys Lys Val Thr His Pro Asp Leu Pro Lys 
    210                 215                 220                 


Asp Ile Val Arg Ser Ile Ala Lys Ala Pro Gly Arg Arg Phe Pro Pro 
225                 230                 235                 240 


Glu Val Tyr Val Phe Leu Pro Pro Glu Gly Glu Pro Lys Thr Lys Asp 
                245                 250                 255     


Lys Val Thr Leu Thr Cys Leu Ile Gln Asn Phe Phe Pro Pro Asp Ile 
            260                 265                 270         


Ser Val Gln Trp Leu His Asn Asp Ser Pro Val Arg Thr Glu Gln Gln 
        275                 280                 285             


Ala Thr Thr Trp Pro His Lys Ala Thr Gly Pro Ser Pro Ala Phe Phe 
    290                 295                 300                 


Val Phe Ser Arg Leu Glu Val Ser Arg Ala Asp Trp Glu Gln Arg Asp 
305                 310                 315                 320 


Val Phe Thr Cys Gln Val Val His Glu Ala Leu Pro Gly Phe Arg Thr 
                325                 330                 335     


Leu Lys Lys Ser Val Ser Lys Asn Pro Gly Lys Met Glu Ser Cys Pro 
            340                 345                 350         


Ile Leu Gln Lys Glu Arg Val Phe Gln Ser Gly Ala His Ala Tyr Arg 
        355                 360                 365             


Ile Pro Ala Leu Leu Tyr Leu Pro Glu Gln Lys Thr Val Leu Ala Phe 
    370                 375                 380                 


Ala Glu Gln Arg Ile Ser Lys Lys Asp Glu His Ala Glu Leu Ile Val 
385                 390                 395                 400 


Leu Arg Arg Gly Ser Tyr Asp Ala Ser Thr His Gln Val Gln Trp His 
                405                 410                 415     


Ala Gln Glu Val Val Ala Gln Ala Gln Leu Glu Gly His Arg Ser Met 
            420                 425                 430         


Asn Pro Ser Pro Leu Tyr Asp Glu Lys Thr Gly Thr Leu Phe Leu Phe 
        435                 440                 445             


Phe Ile Ala Ile Pro Gly Gln Val Ser Glu His His Gln Leu His Thr 
    450                 455                 460                 


Arg Val Asn Val Thr Arg Leu Cys Gln Val Thr Ser Pro Asp His Gly 
465                 470                 475                 480 


Arg Ser Trp Ser Pro Ala Arg Asp Leu Thr Asp Pro Ala Ile Gly Thr 
                485                 490                 495     


Ala His Lys Glu Trp Ala Thr Phe Ala Val Gly Pro Gly His Cys Leu 
            500                 505                 510         


Gln Leu Gly Asn Lys Thr Arg Ser Leu Leu Val Pro Ala Tyr Ala Tyr 
        515                 520                 525             


Arg Asn Leu His Pro His Arg Arg Pro Ser Pro Phe Ala Phe Cys Phe 
    530                 535                 540                 


Val Ser His Asp His Gly His Thr Trp Gln Arg Gly Asn Phe Val Ala 
545                 550                 555                 560 


Gln Asp Thr Val Glu Cys Gln Val Ala Glu Val Gly Gly Ala Glu Gln 
                565                 570                 575     


Arg Val Val Tyr Leu Asn Ala Arg Ser Pro Leu Arg Ala Arg Val Gln 
            580                 585                 590         


Ala Glu Ser Thr Asn Glu Gly Leu Asp Phe Lys Glu Ala Gln Leu Val 
        595                 600                 605             


Glu Glu Leu Val Glu Pro Pro His Gly Cys Gln Gly Ser Ile Val Ser 
    610                 615                 620                 


Phe Pro Gly Pro Gly Ala Gly Ala Asp Ala Ser Asp Arg Trp Leu Leu 
625                 630                 635                 640 


Tyr Thr His Pro Thr Asp Pro Arg Gln Arg Ala His Leu Gly Ala Tyr 
                645                 650                 655     


Leu Ser Lys Pro Arg Pro Gly Pro Ala Ala Trp Ser Glu Pro Ala Leu 
            660                 665                 670         


Leu Ala Thr Gly Ser Cys Ala Tyr Ser Asp Leu Gln Ser Met Gly Thr 
        675                 680                 685             


Gly Pro Asp Gly Ser Pro Gln Phe Gly Cys Leu Tyr Glu Ser Asp Asp 
    690                 695                 700                 


Tyr Glu Ala Val Met Phe Leu Thr Phe Thr Leu Lys Gln Ala Phe Pro 
705                 710                 715                 720 


Ala Glu Phe Leu Ser Leu 
                725     


<210> 32
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210> 33
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210> 34
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Val Arg Ser 
            20                  25                  30          


Leu Val Pro Ser Ser Asp Pro 
        35                  


<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Gly Gly Gly Gly Ser 
1               5   


<210> 36
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Gly Gly Gly Ser 
1               


<210> 37
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Gly Gly Gly Gly Gly Gly 
1               5       


<210> 38
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Gly Ser Gly Gly Ser 
1               5   


<210> 39
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Gly Gly Ser Gly 
1               


<210> 40
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Gly Gly Ser Gly Gly 
1               5   


<210> 41
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Gly Ser Gly Ser Gly 
1               5   


<210> 42
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gly Ser Gly Gly Gly 
1               5   


<210> 43
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gly Gly Gly Ser Gly 
1               5   


<210> 44
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gly Ser Ser Ser Gly 
1               5   


<210> 45
<211> 415
<212> PRT
<213> Canis lupus familiaris

<400> 45
Met Ala Gly Arg Pro Gly Ala Ala Leu Pro Gly Arg Pro Gly Gly Pro 
1               5                   10                  15      


Arg Val Pro Gly Cys Trp Gly Gly Trp Arg Val Arg Ala Arg Ala Ala 
            20                  25                  30          


Thr Phe Leu Leu Leu Trp Pro Leu Ala Gly Leu Gly Ala Gly Ile Lys 
        35                  40                  45              


Asn Asp Phe Ser Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu Leu 
    50                  55                  60                  


Trp Val Ser Gly Arg Gln Ile Gly Asn Val His Thr Phe Arg Ile Pro 
65                  70                  75                  80  


Leu Ile Thr Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala 
                85                  90                  95      


Arg Lys Met Ser Thr Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu Arg 
            100                 105                 110         


Arg Ser Thr Asp Glu Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile Val 
        115                 120                 125             


Asn Asp Gly Glu Thr Pro Asp Gly Leu Asn Leu Gly Ala Val Val Ser 
    130                 135                 140                 


Asp Met Glu Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala His 
145                 150                 155                 160 


Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys Asp 
                165                 170                 175     


Asp Gly Val Ser Trp Ser Pro Pro Arg Asn Leu Ser Leu Asp Ile Gly 
            180                 185                 190         


Thr Glu Met Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Arg His 
        195                 200                 205             


Asp Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu Glu 
    210                 215                 220                 


Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser Trp 
225                 230                 235                 240 


Arg Tyr Gly Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys Arg 
                245                 250                 255     


Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp 
            260                 265                 270         


Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys His 
        275                 280                 285             


Cys Arg Ile Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Ile Arg Pro 
    290                 295                 300                 


Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala Ala 
305                 310                 315                 320 


Gly Ala Val Ala Thr Gly Ser Gly Leu Val Phe Phe Ser Asn Pro Ala 
                325                 330                 335     


His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn 
            340                 345                 350         


Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro Ser 
        355                 360                 365             


Gly Tyr Ser Ser Leu Ala Ala Leu Glu Gly Ser Val Gly Gly Lys Asp 
    370                 375                 380                 


Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn Gln Tyr 
385                 390                 395                 400 


Thr Glu Ser Ile Ser Leu Ala Lys Val Ser Val Tyr Gly Thr Leu 
                405                 410                 415 


<210> 46
<211> 378
<212> PRT
<213> Canis lupus familiaris

<400> 46
Met Ala Ser Cys Pro Val Leu Gln Lys Glu Lys Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gln Gln Lys 
            20                  25                  30          


Thr Leu Leu Ala Phe Ala Glu Lys Arg Thr Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Ser Tyr Asp Ala Ser Thr His 
    50                  55                  60                  


His Val Gln Trp His Ala Gln Glu Val Val Ala Gln Ala Gln Leu Glu 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Ser Pro Leu Tyr Asp Glu Lys Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Ser Glu His 
            100                 105                 110         


His Gln Leu His Thr Arg Val Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Ser Trp Ser Pro Ala Arg Asp Leu Thr Gly 
    130                 135                 140                 


Pro Ala Ile Gly Ala Ala His Lys Glu Trp Ala Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asn Lys Ala Gln Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Asn Leu His Ser Leu Pro Arg Pro Ser Pro 
            180                 185                 190         


Phe Ala Phe Cys Phe Val Ser His Asp His Gly His Thr Trp Glu Arg 
        195                 200                 205             


Gly Asn Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Gly Gly Ala Glu Arg Arg Val Val Tyr Leu Asn Ala Arg Ser Pro Arg 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Glu Ser Thr Asn Glu Gly Leu Asp Phe Thr 
                245                 250                 255     


Glu Ala Gln Val Val Lys Glu Leu Val Glu Pro Pro His Gly Cys Gln 
            260                 265                 270         


Gly Ser Val Ile Ser Phe Pro Asn Pro His Ala Gly Ser Gly Ala Cys 
        275                 280                 285             


Asp Arg Trp Leu Leu Tyr Thr His Pro Thr Asp Pro Gln Arg Arg Ala 
    290                 295                 300                 


His Leu Gly Ala Tyr Leu His Arg Arg Arg Pro Gly Arg Glu Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Val Pro Leu Ala Ala Gly Gly Cys Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ala Met Gly Ala Gly Pro Asp Gly Ser Pro Gln Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ser Gly His Tyr Glu Glu Val Val Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Phe Val Ser 
    370                 375             


<210> 47
<211> 438
<212> PRT
<213> Canis lupus familiaris

<400> 47
Met Glu Glu Pro Glu Ser Arg Gly Glu Val Met Glu Glu Val Thr Ser 
1               5                   10                  15      


Cys Ser Phe Asn Ser Pro Leu Phe Gln Gln Glu Asp Lys Arg Gly Ile 
            20                  25                  30          


Thr Tyr Arg Ile Pro Ala Leu Leu Tyr Ile Pro Pro Thr His Thr Phe 
        35                  40                  45              


Leu Ala Phe Ala Glu Lys Arg Ser Thr Ser Arg Asp Glu Asp Ala Leu 
    50                  55                  60                  


His Leu Val Leu Arg Arg Gly Leu Arg Thr Gly His Ser Val Gln Trp 
65                  70                  75                  80  


Glu Pro Leu Lys Pro Leu Met Glu Ala Met Leu Pro Gly His Arg Thr 
                85                  90                  95      


Met Asn Pro Cys Pro Val Trp Glu Gln Lys Ser Gly Cys Val Tyr Leu 
            100                 105                 110         


Phe Phe Ile Cys Val Arg Gly His Val Thr Glu Arg Gln Gln Val Met 
        115                 120                 125             


Ser Gly Arg Asn Ala Ala Arg Leu Cys Phe Ile Cys Ser Gln Asp Ala 
    130                 135                 140                 


Gly Cys Ser Trp Ser Glu Val Arg Asp Leu Thr Glu Glu Val Ile Gly 
145                 150                 155                 160 


Ala Glu Val Lys Arg Trp Ala Thr Phe Ala Val Gly Pro Gly His Gly 
                165                 170                 175     


Ile Gln Leu Gln Ser Gly Arg Leu Ile Ile Pro Ala Tyr Ala Tyr Tyr 
            180                 185                 190         


Ile Pro Tyr Trp Phe Phe Cys Phe Arg Leu Pro Cys Lys Ala Lys Pro 
        195                 200                 205             


His Ser Leu Met Ile Tyr Ser Asp Asp Leu Gly Ala Thr Trp His His 
    210                 215                 220                 


Gly Arg Leu Ile Lys Pro Thr Ala Thr Val Glu Cys Glu Val Ala Glu 
225                 230                 235                 240 


Val Thr Gly Arg Ala Gly Asp Pro Val Leu Tyr Cys Ser Ala Arg Thr 
                245                 250                 255     


Pro Asn Arg Cys Arg Ala Glu Ala Phe Ser Ile Asn Asn Gly Glu Cys 
            260                 265                 270         


Phe Gln Arg Pro Ala Leu Ser Asn Gln Leu Cys Glu Pro Pro His Gly 
        275                 280                 285             


Cys Gln Gly Ser Val Val Ser Phe Arg Pro Leu Glu Ile Leu His Gly 
    290                 295                 300                 


Tyr Gln Asp Leu Asn Gly Lys Asp Ser Pro Thr Ile Gln Gln Ser Pro 
305                 310                 315                 320 


Leu Leu Asp Ser Ser Leu Trp Pro Glu Gln Glu Gly Gly Ile Leu Ser 
                325                 330                 335     


Lys Ser Trp Leu Leu Tyr Ser His Pro Thr Ser Lys Lys Arg Arg Val 
            340                 345                 350         


Asn Leu Gly Ile Tyr Leu Asn Gln Thr Pro Leu Asp Ala Ala Cys Trp 
        355                 360                 365             


Ser Arg Pro Trp Ile Leu His Cys Gly Pro Cys Gly Tyr Ser Asp Leu 
    370                 375                 380                 


Ala Ala Leu Glu Lys Glu Gly Leu Phe Gly Cys Leu Phe Glu Cys Gly 
385                 390                 395                 400 


Thr Lys Arg Glu Cys Glu Gln Ile Ala Phe Arg Leu Phe Thr Asp Arg 
                405                 410                 415     


Glu Ile Leu Ser His Met His Glu Asp Ser Thr Gly Pro Gly Lys Asn 
            420                 425                 430         


Ser Glu Pro Thr Glu Ser 
        435             


<210> 48
<211> 417
<212> PRT
<213> Felis catus

<400> 48
Met Met Ala Asp Arg Ala Gly Gln Val Leu Leu Gly Arg Pro Gly Asp 
1               5                   10                  15      


Pro Arg Met Pro Gly Phe Trp Gly Gly Cys Arg Val Gln Val Leu Ala 
            20                  25                  30          


Thr Ile Ile Phe Leu Leu Leu Leu Ser Leu Ala Glu Ser Gly Ala Arg 
        35                  40                  45              


Ala Lys Asn Asp Phe Ser Leu Val Gln Pro Leu Val Thr Met Glu Gln 
    50                  55                  60                  


Leu Leu Trp Val Ser Gly Arg Gln Ile Gly Ser Val His Thr Phe Arg 
65                  70                  75                  80  


Ile Pro Leu Ile Thr Thr Thr Pro Gln Gly Thr Leu Leu Ala Phe Ala 
                85                  90                  95      


Glu Ala Arg Lys Met Ser Thr Ser Asp Glu Gly Ala Lys Phe Ile Ala 
            100                 105                 110         


Leu Arg Arg Ser Leu Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe 
        115                 120                 125             


Ile Val Asp Asp Gly Asp Thr Pro Asp Gly Leu Asn Leu Gly Ala Val 
    130                 135                 140                 


Val Asn Asp Met Glu Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys 
145                 150                 155                 160 


Ala His Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser 
                165                 170                 175     


Lys Asp Asp Gly Val Ser Trp Ser Pro Pro Arg Asn Leu Ser Leu Asp 
            180                 185                 190         


Ile Gly Thr Glu Met Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys 
        195                 200                 205             


Gln Arg Glu Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr 
    210                 215                 220                 


Leu Glu Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala 
225                 230                 235                 240 


Thr Trp Arg Tyr Gly Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro 
                245                 250                 255     


Lys Arg Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu 
            260                 265                 270         


Pro Asp Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His 
        275                 280                 285             


Cys His Cys Arg Ile Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Ile 
    290                 295                 300                 


Arg Pro Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val 
305                 310                 315                 320 


Ala Ala Gly Ala Val Ala Thr Ser Ser Gly Ile Val Phe Phe Ser Asn 
                325                 330                 335     


Pro Ala His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe 
            340                 345                 350         


Ser Asn Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly 
        355                 360                 365             


Pro Ser Gly Tyr Ser Ser Leu Ala Ala Leu Glu Gly Asn Val Gly Gly 
    370                 375                 380                 


Lys Asp Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn 
385                 390                 395                 400 


Gln Tyr Thr Glu Ser Ile Ser Leu Ala Lys Val Ser Val Tyr Gly Thr 
                405                 410                 415     


Leu 
    


<210> 49
<211> 379
<212> PRT
<213> Felis catus

<400> 49
Met Glu Ser Cys Pro Ile Leu Gln Lys Glu Arg Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Glu Gln Lys 
            20                  25                  30          


Thr Val Leu Ala Phe Ala Glu Gln Arg Ile Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Ser Tyr Asp Ala Ser Thr His 
    50                  55                  60                  


Gln Val Gln Trp His Ala Gln Glu Val Val Ala Gln Ala Gln Leu Glu 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Ser Pro Leu Tyr Asp Glu Lys Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Ser Glu His 
            100                 105                 110         


His Gln Leu His Thr Arg Val Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Pro Asp His Gly Arg Ser Trp Ser Pro Ala Arg Asp Leu Thr Asp 
    130                 135                 140                 


Pro Ala Ile Gly Thr Ala His Lys Glu Trp Ala Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu Gly Asn Lys Thr Arg Ser Leu Leu Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Asn Leu His Pro His Arg Arg Pro Ser Pro 
            180                 185                 190         


Phe Ala Phe Cys Phe Val Ser His Asp His Gly His Thr Trp Gln Arg 
        195                 200                 205             


Gly Asn Phe Val Ala Gln Asp Thr Val Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Gly Gly Ala Glu Gln Arg Val Val Tyr Leu Asn Ala Arg Ser Pro Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Glu Ser Thr Asn Glu Gly Leu Asp Phe Lys 
                245                 250                 255     


Glu Ala Gln Leu Val Glu Glu Leu Val Glu Pro Pro His Gly Cys Gln 
            260                 265                 270         


Gly Ser Ile Val Ser Phe Pro Gly Pro Gly Ala Gly Ala Asp Ala Ser 
        275                 280                 285             


Asp Arg Trp Leu Leu Tyr Thr His Pro Thr Asp Pro Arg Gln Arg Ala 
    290                 295                 300                 


His Leu Gly Ala Tyr Leu Ser Lys Pro Arg Pro Gly Pro Ala Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Ala Leu Leu Ala Thr Gly Ser Cys Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Gln Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ser Asp Asp Tyr Glu Ala Val Met Phe Leu Thr Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Phe Leu Ser Leu 
    370                 375                 


<210> 50
<211> 438
<212> PRT
<213> Felis catus

<400> 50
Met Glu Glu Leu Gly Ser Arg Glu Glu Val Met Glu Glu Val Thr Ser 
1               5                   10                  15      


Cys Ser Phe Ser Ser Pro Leu Phe Gln Gln Glu Asp Lys Arg Gly Ile 
            20                  25                  30          


Thr Tyr Arg Ile Pro Ala Leu Leu Tyr Ile Pro Pro Thr His Thr Phe 
        35                  40                  45              


Leu Ala Phe Ala Glu Lys Arg Ser Thr Ser Arg Asp Glu Asp Ala Leu 
    50                  55                  60                  


His Leu Val Leu Arg Arg Gly Leu Arg Thr Gly His Ser Val Gln Trp 
65                  70                  75                  80  


Gly Pro Leu Lys Pro Leu Met Glu Ala Thr Leu Pro Gly His Arg Thr 
                85                  90                  95      


Met Asn Pro Cys Pro Val Trp Glu Gln Lys Ser Gly Cys Val Tyr Leu 
            100                 105                 110         


Phe Phe Ile Cys Val Arg Gly His Val Thr Glu Arg Gln Gln Ile Met 
        115                 120                 125             


Ser Gly Arg Asn Ala Ala Arg Leu Cys Phe Ile Cys Ser Arg Asp Thr 
    130                 135                 140                 


Gly Cys Ser Trp Ser Glu Val Arg Asp Leu Thr Glu Glu Val Ile Gly 
145                 150                 155                 160 


Ala Glu Val Lys Arg Trp Ala Thr Phe Ala Val Gly Pro Gly His Gly 
                165                 170                 175     


Ile Gln Leu Gln Ser Gly Arg Leu Val Ile Pro Ala Tyr Ala Tyr Tyr 
            180                 185                 190         


Ile Pro Tyr Trp Phe Phe Cys Phe Arg Leu Pro Cys Lys Ala Lys Pro 
        195                 200                 205             


His Ser Leu Met Ile Tyr Ser Asp Asp Leu Gly Ala Thr Trp His His 
    210                 215                 220                 


Gly Arg Leu Ile Gln Pro Met Ala Thr Val Glu Cys Glu Val Ala Glu 
225                 230                 235                 240 


Val Thr Gly Arg Gly Gly Asn Pro Val Leu Tyr Cys Ser Ala Arg Thr 
                245                 250                 255     


Pro Asn Arg Cys Arg Ala Glu Ala Phe Ser Asp Asp Arg Gly Glu Cys 
            260                 265                 270         


Phe Gln Arg Leu Ala Leu Ser Arg Glu Leu Cys Glu Pro Pro His Gly 
        275                 280                 285             


Cys Gln Gly Ser Val Val Ser Phe Arg Pro Pro Glu Ile Leu Arg Gly 
    290                 295                 300                 


Cys Gln Asp Pro Asn Gly Lys Asp Ala Ser Thr Ile Gln Gln Ser Pro 
305                 310                 315                 320 


Leu Leu Asp Arg Ser Leu Arg Leu Glu Gln Glu Ala Gly Thr Leu Ser 
                325                 330                 335     


Glu Ser Trp Leu Leu Tyr Ser His Pro Thr Cys Lys Lys Arg Arg Val 
            340                 345                 350         


Asn Leu Gly Ile Tyr Leu Asn Gln Thr Pro Leu Asp Ala Ala Cys Trp 
        355                 360                 365             


Ser His Pro Trp Ile Leu His Cys Gly Pro Cys Gly Tyr Ser Asp Leu 
    370                 375                 380                 


Ala Ala Leu Glu Lys Glu Gly Leu Phe Gly Cys Leu Phe Glu Cys Gly 
385                 390                 395                 400 


Thr Lys Arg Glu Cys Glu Gln Ile Ala Phe Arg Leu Phe Thr Asp Arg 
                405                 410                 415     


Glu Ile Leu Ser His Val His Gly Asp Phe Thr Ser Pro Asp Lys Asn 
            420                 425                 430         


Pro Glu Pro Ile Glu Ser 
        435             


<210> 51
<211> 346
<212> PRT
<213> Felis catus


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 51
Thr Trp Xaa Ala Ala Arg Asp Leu Thr Glu Glu Ala Val Gly Gly Ala 
1               5                   10                  15      


Glu Gln Asp Trp Ala Thr Phe Ala Val Gly Pro Gly His Gly Ile Gln 
            20                  25                  30          


Leu Arg Ser Gly Arg Leu Leu Val Pro Ala Tyr Thr Tyr His Val Asp 
        35                  40                  45              


Arg Arg Glu Cys Phe Gly Lys Ile Cys Arg Thr Ser Pro His Ala Phe 
    50                  55                  60                  


Thr Phe Tyr Ser Asp Asp His Gly Arg Thr Trp Arg His Gly Gly Leu 
65                  70                  75                  80  


Val Pro Asn Leu Arg Ser Gly Glu Cys Gln Leu Ala Ala Val Asp Arg 
                85                  90                  95      


Gly Gln Ala Gly His Ile Leu Tyr Cys Asn Ala Arg Ser Pro Leu Gly 
            100                 105                 110         


Ser Arg Val Gln Ala Leu Ser Ala Asp Glu Gly Thr Ser Phe Leu Pro 
        115                 120                 125             


Gly Glu Leu Val Pro Ala Leu Ala Glu Thr Ala Arg Gly Cys Gln Gly 
    130                 135                 140                 


Ser Val Leu Gly Phe Pro Ala Pro Leu Phe Ser Arg Pro Arg Asn Gly 
145                 150                 155                 160 


Arg Trp Pro Val Gly Ala Gly Ser His Ser Tyr Ser Pro His Leu Cys 
                165                 170                 175     


Leu Gly Val Gln Glu Pro Ser Glu Glu Gly Thr Gly Asp Thr Gln Gly 
            180                 185                 190         


Ala Gln Gly Pro Ser Gly Met Glu Gly Cys Arg Asp Ser Pro Glu Glu 
        195                 200                 205             


Pro Gly Leu Gly Pro Gly Leu Ser Gly Ile Met Ala Ala Trp Thr Ser 
    210                 215                 220                 


Lys Val Pro Gly Pro Pro Ala Thr Leu Ser Gln Ser Pro Thr Trp Leu 
225                 230                 235                 240 


Leu Tyr Ser His Pro Val Gly Arg Arg Ala Arg Leu His Met Gly Ile 
                245                 250                 255     


Tyr Leu Ser Arg Ser Pro Leu Asp Pro His Ser Trp Thr Glu Pro Trp 
            260                 265                 270         


Val Ile Tyr Glu Gly Pro Ser Gly Tyr Ser Asp Leu Ala Ser Val Gly 
        275                 280                 285             


Pro Thr Val Lys Gly Ala Leu Thr Phe Ala Cys Leu Phe Glu Ser Gly 
    290                 295                 300                 


Ala Arg Val Ser Tyr Glu Glu Ile Ser Phe Cys Met Phe Ser Leu Gly 
305                 310                 315                 320 


Glu Val Leu Gln Asn Leu Pro Pro Gly Pro Lys Pro Pro Gly Leu Gly 
                325                 330                 335     


Asp Lys Pro Leu Glu Arg Cys Arg Pro Ser 
            340                 345     


<210> 52
<211> 425
<212> PRT
<213> Bos taurus

<400> 52
Ser Ile Gln Ala Pro Ser Ile Tyr Pro Leu Arg Leu Cys Cys Thr Glu 
1               5                   10                  15      


Glu Ala Arg Val Arg Leu Gly Cys Leu Val Lys Asp Tyr Leu Pro Gly 
            20                  25                  30          


Ser Val Thr Val Thr Trp Asp Thr Val Pro Leu Asp Gly Ser Thr Leu 
        35                  40                  45              


Thr Phe Pro Ser Ile Gln Met Ala Ser Ser Ser Leu Tyr Ile Thr Thr 
    50                  55                  60                  


Ser Gln Leu Thr Ile Ser Gly Glu Gln Ser Lys Glu Phe Thr Cys Arg 
65                  70                  75                  80  


Val Leu His Pro Glu Thr Asn Ser Asn Leu Asn Lys Thr Ile Ser Thr 
                85                  90                  95      


Glu Cys Ala Lys Asn Phe Ser Asp Pro Ser Val Lys Leu Phe Tyr Ser 
            100                 105                 110         


Ser Cys Asn Pro Asn Gly Asp Thr Gln Thr Thr Ile His Leu Leu Cys 
        115                 120                 125             


Arg Ile Ser Gly Tyr Thr Pro Gly Lys Ile Lys Val Thr Trp Leu Val 
    130                 135                 140                 


Asp Gly Leu Gln Ser Glu Glu Leu Tyr Ala Arg Ser Gly Pro Glu Ile 
145                 150                 155                 160 


Gln Glu Gly Asn Leu Thr Ser Thr Tyr Ser Glu Val Asn Ile Thr Gln 
                165                 170                 175     


Gly Gln Trp Val Ser Glu Lys Thr Tyr Thr Cys Arg Val Asn Tyr Tyr 
            180                 185                 190         


Gly Tyr Asn Phe Glu Ser His Ala His Arg Cys Thr Ala Glu Ser Glu 
        195                 200                 205             


Pro Arg Gly Val Ser Ala Tyr Leu Ser Pro Pro Thr Pro Leu Glu Leu 
    210                 215                 220                 


Tyr Val Asn Lys Ser Pro Lys Ile Thr Cys Leu Val Val Asp Leu Ala 
225                 230                 235                 240 


Asn Glu Lys Asn Leu Ser Leu Thr Trp Ser Arg Ala Asn Gly Lys Pro 
                245                 250                 255     


Val His Ala Gly Pro Pro Glu Ile Lys Arg Gln Phe Asn Gly Thr Val 
            260                 265                 270         


Thr Val Thr Ser Thr Leu Pro Val Asp Val Thr Asp Trp Val Glu Gly 
        275                 280                 285             


Glu Thr Tyr Tyr Cys Lys Val Ser His Ser Asp Leu Pro Thr Asp Ile 
    290                 295                 300                 


Gln Arg Ser Ile Ser Lys Asp Val Gly Lys Arg Leu Ala Pro Lys Ala 
305                 310                 315                 320 


Tyr Val Phe Leu Pro Asp Gly Lys Glu Leu Glu Asn Glu Glu Glu Leu 
                325                 330                 335     


Thr Leu Thr Cys Met Ile Gln Lys Phe Phe Pro Arg Asp Ile Phe Val 
            340                 345                 350         


Arg Trp Leu His Asn Lys Glu Leu Met Arg Ala Asp Gln His Thr Thr 
        355                 360                 365             


Thr Gln Pro His Arg Ala Asp Asn Asn Thr Pro Ala Phe Phe Ala Tyr 
    370                 375                 380                 


Ser Arg Leu Ala Val Pro Arg Ala Asn Trp Lys Arg Gly Asp Glu Phe 
385                 390                 395                 400 


Thr Cys Gln Val Ile His Glu Ala Leu Pro Arg Thr Arg Thr Leu Glu 
                405                 410                 415     


Lys Ser Val Phe Ile Asn Ser Gly Lys 
            420                 425 


<210> 53
<211> 428
<212> PRT
<213> Bos taurus

<400> 53
Met Glu Glu Val Thr Ser Cys Ser Phe Ser Ser Pro Leu Phe Gln Gln 
1               5                   10                  15      


Glu Asp Lys Arg Gly Val Thr Tyr Arg Ile Pro Ala Leu Ile Tyr Val 
            20                  25                  30          


Pro Pro Ala His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Ser Ser 
        35                  40                  45              


Lys Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg Thr 
    50                  55                  60                  


Gly Gln Ser Val Gln Trp Glu Pro Leu Lys Ser Leu Met Lys Ala Thr 
65                  70                  75                  80  


Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Arg Lys 
                85                  90                  95      


Ser Gly Tyr Val Tyr Leu Phe Phe Ile Cys Val Gln Gly His Val Thr 
            100                 105                 110         


Glu Arg Gln Gln Ile Met Ser Gly Arg Asn Pro Ala Arg Leu Cys Phe 
        115                 120                 125             


Ile Cys Ser Gln Asp Ala Gly Tyr Ser Trp Ser Asp Val Arg Asp Leu 
    130                 135                 140                 


Thr Glu Glu Val Ile Gly Pro Glu Val Thr His Trp Ala Thr Phe Ala 
145                 150                 155                 160 


Val Gly Pro Gly His Gly Ile Gln Leu Gln Ser Gly Arg Leu Ile Ile 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Tyr Ile Pro Phe Trp Phe Phe Cys Phe Arg Leu 
            180                 185                 190         


Pro Tyr Arg Ala Arg Pro His Ser Leu Met Ile Tyr Ser Asp Asp Leu 
        195                 200                 205             


Gly Ala Thr Trp His His Gly Arg Leu Ile Lys Pro Met Val Thr Val 
    210                 215                 220                 


Glu Cys Glu Val Ala Glu Val Ile Gly Lys Ala Gly His Pro Val Leu 
225                 230                 235                 240 


Tyr Cys Ser Ala Arg Thr Pro Asn Arg His Arg Ala Glu Ala Leu Ser 
                245                 250                 255     


Ile Asp His Gly Glu Cys Phe Gln Lys Pro Val Leu Ser His Gln Leu 
            260                 265                 270         


Cys Glu Pro Pro His Gly Cys Gln Gly Ser Val Val Ser Phe Cys Pro 
        275                 280                 285             


Leu Glu Ile Pro Gly Gly Cys Gln Asp Leu Ala Gly Glu Asp Ala Pro 
    290                 295                 300                 


Ala Ile Gln Gln Ser Pro Leu Leu Cys Ser Ser Val Arg Pro Glu Pro 
305                 310                 315                 320 


Glu Ala Gly Thr Leu Ser Glu Ser Trp Leu Leu Tyr Ser His Pro Thr 
                325                 330                 335     


Asn Lys Lys Arg Arg Val Asp Leu Gly Ile Tyr Leu Asn Gln Ser Pro 
            340                 345                 350         


Leu Glu Ala Ala Cys Trp Ser Arg Pro Trp Ile Leu His Cys Gly Pro 
        355                 360                 365             


Cys Gly Tyr Ser Asp Leu Ala Ala Leu Glu Asn Glu Gly Leu Phe Gly 
    370                 375                 380                 


Cys Leu Phe Glu Cys Gly Thr Lys Gln Glu Cys Glu Gln Ile Ala Phe 
385                 390                 395                 400 


Arg Leu Phe Thr Asp Arg Glu Ile Leu Ser His Val Gln Gly Asp Cys 
                405                 410                 415     


Ser Thr Pro Gly Met Asn Ser Glu Pro Ser Lys Lys 
            420                 425             


<210> 54
<211> 415
<212> PRT
<213> Bos taurus

<400> 54
Met Thr Glu Glu Gly Pro Gly Ile Val Ser Leu Gly Lys Leu Arg Arg 
1               5                   10                  15      


Pro Arg Met Leu Arg Leu Trp Gly Ile Cys Arg Val Gln Ile Phe Ser 
            20                  25                  30          


Ala Ile Phe Met Leu Met Ser Pro Ala Gly Val Gly Ala Gly Ala Lys 
        35                  40                  45              


Asp Asp Phe Ser Leu Val His Pro Leu Val Thr Met Glu Gln Leu Leu 
    50                  55                  60                  


Trp Val Ser Gly Lys Gln Ile Gly Ser Val Asp Thr Phe Arg Ile Pro 
65                  70                  75                  80  


Leu Ile Thr Thr Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala 
                85                  90                  95      


Arg Lys Met Ser Thr Ser Asp Lys Gly Ala Lys Phe Ile Ala Leu Arg 
            100                 105                 110         


Arg Ser Met Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile Val 
        115                 120                 125             


Asp Asp Gly Glu Thr Pro Asp Gly Leu Asn Leu Gly Ala Val Val Ser 
    130                 135                 140                 


Asp Thr Thr Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala His 
145                 150                 155                 160 


Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys Asp 
                165                 170                 175     


Asp Gly Val Ser Trp Ser Ser Pro Arg Asn Leu Ser Leu Asp Ile Gly 
            180                 185                 190         


Thr Glu Met Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln Arg 
        195                 200                 205             


Glu Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu Glu 
    210                 215                 220                 


Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Val Ser Trp 
225                 230                 235                 240 


Arg Tyr Gly Gly Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys Arg 
                245                 250                 255     


Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp 
            260                 265                 270         


Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys His 
        275                 280                 285             


Cys Arg Ile Ile Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg Pro 
    290                 295                 300                 


Arg Asp Val Thr Phe Asp Thr Glu Leu Val Asp Pro Val Val Ala Ala 
305                 310                 315                 320 


Gly Ala Val Ala Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro Ala 
                325                 330                 335     


His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn 
            340                 345                 350         


Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro Ser 
        355                 360                 365             


Gly Tyr Ser Ser Leu Thr Thr Leu Glu Gly Asn Val Asp Gly Lys Asp 
    370                 375                 380                 


Glu Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn Gln Tyr 
385                 390                 395                 400 


Met Glu Ser Ile Ser Leu Val Lys Val Ser Val Tyr Gly Thr Leu 
                405                 410                 415 


<210> 55
<211> 424
<212> PRT
<213> Equus caballus

<400> 55
Val Ser Lys Gln Ala Pro Leu Ile Leu Pro Leu Ala Ala Cys Cys Lys 
1               5                   10                  15      


Asp Thr Lys Thr Thr Asn Ile Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asp Ala Gly Ser Leu Asn Arg 
        35                  40                  45              


Ser Thr Met Thr Phe Pro Ala Val Phe Asp Gln Thr Ser Gly Leu Tyr 
    50                  55                  60                  


Thr Thr Ile Ser Arg Val Val Ala Ser Gly Lys Trp Ala Lys Gln Lys 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Ser Gln Glu Thr Phe Asn Lys Thr Phe 
                85                  90                  95      


Asn Ala Cys Ile Val Thr Phe Thr Pro Pro Thr Val Lys Leu Phe His 
            100                 105                 110         


Ser Ser Cys Asp Pro Gly Gly Asp Ser His Thr Thr Ile Gln Leu Leu 
        115                 120                 125             


Cys Leu Ile Ser Asp Tyr Thr Pro Gly Asp Ile Asp Ile Val Trp Leu 
    130                 135                 140                 


Ile Asp Gly Gln Lys Val Asp Glu Gln Phe Pro Gln His Gly Leu Val 
145                 150                 155                 160 


Lys Gln Glu Gly Lys Leu Ala Ser Thr His Ser Glu Leu Asn Ile Thr 
                165                 170                 175     


Gln Gly Gln Trp Ala Ser Glu Asn Thr Tyr Thr Cys Gln Val Thr Tyr 
            180                 185                 190         


Lys Asp Met Ile Phe Lys Asp Gln Ala Arg Lys Cys Thr Glu Ser Asp 
        195                 200                 205             


Pro Arg Gly Val Ser Val Tyr Leu Ser Pro Pro Ser Pro Leu Asp Leu 
    210                 215                 220                 


Tyr Val Ser Lys Ser Pro Lys Ile Thr Cys Leu Val Val Asp Leu Ala 
225                 230                 235                 240 


Asn Val Gln Gly Leu Ser Leu Asn Trp Ser Arg Glu Ser Gly Glu Pro 
                245                 250                 255     


Leu Gln Lys His Thr Leu Ala Thr Ser Glu Gln Phe Asn Lys Thr Phe 
            260                 265                 270         


Ser Val Thr Ser Thr Leu Pro Val Asp Thr Thr Asp Trp Ile Glu Gly 
        275                 280                 285             


Glu Thr Tyr Lys Cys Thr Val Ser His Pro Asp Leu Pro Arg Glu Val 
    290                 295                 300                 


Val Arg Ser Ile Ala Lys Ala Pro Gly Lys Arg Leu Ser Pro Glu Val 
305                 310                 315                 320 


Tyr Val Phe Leu Pro Pro Glu Glu Asp Gln Ser Ser Lys Asp Lys Val 
                325                 330                 335     


Thr Leu Thr Cys Leu Ile Gln Asn Phe Phe Pro Ala Asp Ile Ser Val 
            340                 345                 350         


Gln Trp Leu Arg Asn Asn Val Leu Ile Gln Thr Asp Gln Gln Ala Thr 
        355                 360                 365             


Thr Arg Pro Gln Lys Ala Asn Gly Pro Asn Pro Ala Phe Phe Val Phe 
    370                 375                 380                 


Ser Arg Leu Glu Val Ser Arg Ala Glu Trp Glu Gln Lys Asn Lys Phe 
385                 390                 395                 400 


Ala Cys Lys Val Val His Glu Ala Leu Ser Gln Arg Thr Leu Gln Lys 
                405                 410                 415     


Glu Val Ser Lys Asp Pro Gly Lys 
            420                 


<210> 56
<211> 416
<212> PRT
<213> Equus caballus

<400> 56
Met Met Ala Glu Arg Ser Gly Thr Val Leu Arg Asp Arg Pro Gly Gly 
1               5                   10                  15      


Pro Arg Thr Leu Gly Phe Trp Gly Gly Cys Arg Val Gln Val Leu Ala 
            20                  25                  30          


Ala Ile Phe Leu Leu Leu Leu Ser Leu Ala Arg Phe Gly Thr Arg Ala 
        35                  40                  45              


Gly Asn Asp Phe Asp Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu 
    50                  55                  60                  


Leu Trp Val Ser Gly Lys Gln Ile Gly Ser Val Asp Thr Phe Arg Ile 
65                  70                  75                  80  


Pro Leu Ile Thr Val Thr Pro Gln Gly Thr Leu Leu Ala Phe Ala Glu 
                85                  90                  95      


Ala Arg Lys Met Ser Ser Ser Asp Leu Gly Ala Lys Phe Ile Ala Leu 
            100                 105                 110         


Arg Arg Ser Met Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile 
        115                 120                 125             


Val Asp Asp Gly Glu Thr Pro Asp Gly Leu Asn Leu Gly Ala Val Val 
    130                 135                 140                 


Ser Asp Arg Glu Thr Gly Ile Val Phe Leu Phe Tyr Ser Leu Cys Ala 
145                 150                 155                 160 


His Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys 
                165                 170                 175     


Asp Asp Gly Val Ser Trp Ser Ser Pro Arg Asn Leu Ser Leu Asp Ile 
            180                 185                 190         


Gly Thr Glu Val Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln 
        195                 200                 205             


Arg Gln Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu 
    210                 215                 220                 


Glu Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser 
225                 230                 235                 240 


Trp Arg Tyr Gly Asn Gly Ile Arg Gly Ile Pro Tyr Gly Gln Pro Lys 
                245                 250                 255     


Gln Lys Tyr Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro 
            260                 265                 270         


Asp Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys 
        275                 280                 285             


His Cys Arg Ile Ile Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg 
    290                 295                 300                 


Pro Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala 
305                 310                 315                 320 


Ala Gly Ala Val Ala Thr Asn Ser Gly Ile Val Phe Phe Ser Asn Pro 
                325                 330                 335     


Ala His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser 
            340                 345                 350         


Asn Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro 
        355                 360                 365             


Ser Gly Tyr Ser Ser Met Ala Ala Leu Glu Gly Ser Leu Gly Gly Glu 
    370                 375                 380                 


Asp Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Leu Ser Gln 
385                 390                 395                 400 


Tyr Thr Glu Ser Ile Ser Leu Ala Lys Val Ser Val Tyr Gly Thr Leu 
                405                 410                 415     


<210> 57
<211> 379
<212> PRT
<213> Equus caballus

<400> 57
Met Ala Ser Cys Pro Ile Leu Gln Lys Glu Lys Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gln Gln Lys 
            20                  25                  30          


Thr Leu Leu Ala Phe Ala Glu Lys Arg Arg Asp Lys Arg Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Ala Leu Arg Lys Gly Ser Tyr Asp Val Ala Thr His 
    50                  55                  60                  


Arg Val Leu Trp His Ala Glu Glu Val Val Thr Gln Ala Gln Leu Glu 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Ser Pro Leu Tyr Asp Lys Lys Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ser Ile Pro Gly Gln Val Ser Glu Arg 
            100                 105                 110         


His Gln Leu His Thr Arg Val Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Ser Trp Ser Pro Ala Arg Asp Val Thr Asp 
    130                 135                 140                 


Ser Ile Ile Gly Ser Ala Tyr Lys Glu Trp Ala Thr Phe Ala Leu Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asn Glu Ser Gln Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Asn Leu His Pro Arg His Arg Pro Ala Pro 
            180                 185                 190         


Phe Ala Val Cys Phe Ile Ser His Asp His Gly His Thr Trp Gln Arg 
        195                 200                 205             


Gly Asn Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Gly Ser Thr Lys Gln Arg Val Val Tyr Leu Asn Ala Arg Ser Pro Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Glu Ser Asn Asn Asp Gly Leu Asp Phe Lys 
                245                 250                 255     


Glu Ile Gln Leu Val Thr Lys Leu Ala Glu Pro Pro Gln Gly Cys Gln 
            260                 265                 270         


Gly Ser Ile Val Ser Phe Pro Asn Pro Thr Val Gln Ser Asp Phe Ser 
        275                 280                 285             


Asp Lys Trp Leu Leu Tyr Thr His Pro Thr Asp Ser Arg Gln Arg Ser 
    290                 295                 300                 


Asn Leu Gly Val Tyr Leu Asn Lys Trp Pro Leu Ala Pro Thr Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Thr Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Ala Gly Pro Asp Gly Ser Pro Gln Phe Ala Cys Leu 
            340                 345                 350         


Tyr Glu Ser Asn Asn Tyr Glu Glu Ile Ile Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Phe Leu Pro Gln 
    370                 375                 


<210> 58
<211> 428
<212> PRT
<213> Equus caballus

<400> 58
Met Glu Glu Val Thr Ser Cys Ser Phe Asn Ser Pro Leu Phe Gln Gln 
1               5                   10                  15      


Glu Asp Lys Arg Gly Val Thr Tyr Arg Ile Pro Ala Leu Leu Tyr Val 
            20                  25                  30          


Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr Cys 
        35                  40                  45              


Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Val Arg Thr 
    50                  55                  60                  


Glu His Ser Val Gln Trp Gly Pro Leu Lys Pro Leu Met Glu Ala Thr 
65                  70                  75                  80  


Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Gln Lys 
                85                  90                  95      


Ser Gly Cys Val Tyr Leu Phe Phe Ile Cys Val Arg Asp His Val Thr 
            100                 105                 110         


Glu Arg Gln Gln Ile Val Ser Gly Arg Asn Ala Ala Arg Leu Cys Phe 
        115                 120                 125             


Ile Cys Ser Gln Asp Ala Gly Cys Ser Trp Ser Glu Leu Arg Asp Leu 
    130                 135                 140                 


Thr Glu Glu Val Ile Gly Pro Glu Met Lys Arg Trp Ala Thr Phe Ala 
145                 150                 155                 160 


Val Gly Pro Gly His Gly Ile Gln Leu Gln Ser Gly Arg Leu Val Ile 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Tyr Ile Pro Tyr Leu Phe Phe Cys Phe Arg Leu 
            180                 185                 190         


Pro Cys Lys Ala Arg Pro His Ser Leu Met Ile Tyr Ser Asp Asp Leu 
        195                 200                 205             


Gly Ala Thr Trp His His Gly Arg Leu Ile Lys Pro Met Val Thr Val 
    210                 215                 220                 


Glu Cys Glu Val Ala Glu Val Thr Glu Arg Thr Gly Tyr Pro Val Leu 
225                 230                 235                 240 


Tyr Cys Ser Ala Arg Thr Pro Asn Arg Cys Arg Ala Glu Ala Leu Ser 
                245                 250                 255     


Thr Asp His Gly Glu Cys Phe Gln Arg Pro Ala Leu Ser Gln Gln Leu 
            260                 265                 270         


Cys Glu Pro Pro His Gly Cys Gln Gly Ser Val Val Ser Phe Gln Pro 
        275                 280                 285             


Leu Glu Ile Pro His Gly Tyr Gln Asp Pro Ser Gly Gln Asp Ala Pro 
    290                 295                 300                 


Thr Ile Gln Gln Asn Pro Leu Leu Asp Ser Ser Leu Arg Leu Glu Gln 
305                 310                 315                 320 


Glu Ala Gly Thr Leu Ser Gln Ser Trp Leu Leu Tyr Ser His Pro Thr 
                325                 330                 335     


Ser Lys Lys Arg Arg Val Asn Leu Gly Ile Tyr Leu Asn Gln Thr Pro 
            340                 345                 350         


Leu Glu Ala Thr Cys Trp Ser Arg Pro Trp Ile Leu His Cys Gly Pro 
        355                 360                 365             


Cys Gly Tyr Ser Asp Leu Ala Ala Leu Glu Lys Glu Gly Leu Phe Ala 
    370                 375                 380                 


Cys Leu Phe Glu Cys Gly Ile Lys Arg Glu Cys Glu Gln Ile Ala Phe 
385                 390                 395                 400 


Arg Leu Phe Thr Val Gln Glu Ile Val Ser His Val Gln Gly Asp Cys 
                405                 410                 415     


Thr Ser Pro Gly Arg Ile Ser Glu Pro Ile Gln Asn 
            420                 425             


<210> 59
<211> 2199
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 59
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ggatccccag cacagtggaa gcttgagaac gacttcggtc tggtgcagcc gctggtgacc      120

atggagcaac tgctgtgggt gagcgggaga cagatcggct cagtggacac cttccgcatc      180

ccgctcatca cagccactcc gcggggcact cttctcgcct ttgctgaggc gaggaaaatg      240

tcctcatccg atgagggggc caagttcatc gccctgcgga ggtccatgga ccagggcagc      300

acatggtctc ctacagcgtt cattgtcaat gatggggatg tccccgatgg gctgaacctt      360

ggggcagtag tgagcgatgt tgagacagga gtagtatttc ttttctactc cctttgtgct      420

cacaaggccg gctgccaggt ggcctctacc atgttggtat ggagcaagga tgatggtgtt      480

tcctggagca caccccggaa tctctccctg gatattggca ctgaagtgtt tgcccctgga      540

ccgggctctg gtattcagaa acagcgggag ccacggaagg gccgcctcat cgtgtgtggc      600

catgggacgc tggagcggga cggagtcttc tgtctcctca gcgatgatca tggtgcctcc      660

tggcgctacg gaagtggggt cagcggcatc ccctacggtc agcccaagca ggaaaatgat      720

ttcaatcctg atgaatgcca gccctatgag ctcccagatg gctcagtcgt catcaatgcc      780

cgaaaccaga acaactacca ctgccactgc cgaattgtcc tccgcagcta tgatgcctgt      840

gatacactaa ggccccgtga tgtgaccttc gaccctgagc tcgtggaccc tgtggtagct      900

gcaggagctg tagtcaccag ctccggcatt gtcttcttct ccaacccagc acatccagag      960

ttccgagtga acctgaccct gcgatggagc ttcagcaatg gtacctcatg gcggaaagag     1020

acagtccagc tatggccagg ccccagtggc tattcatccc tggcaaccct ggagggcagc     1080

atggatggag aggagcaggc cccccagctc tacgtcctgt atgagaaagg ccggaaccac     1140

tacacagaga gcatctccgt ggccaaaatc agtgtctatg ggacactcgg aggaggagga     1200

ggaggatgct ccagggactt caccccgccc accgtgaaga tcttacagtc gtcctgcgac     1260

ggcggcgggc acttcccccc gaccatccag ctcctgtgcc tcgtctctgg gtacacccca     1320

gggactatca acatcacctg gctggaggac gggcaggtca tggacgtgga cttgtccacc     1380

gcctctacca cgcaggaggg tgagctggcc tccacacaaa gcgagctcac cctcagccag     1440

aagcactggc tgtcagaccg cacctacacc tgccaggtca cctatcaagg tcacaccttt     1500

gaggacagca ccaagaagtg tgcagattcc aacccgagag gggtgagcgc ctacctaagc     1560

cggcccagcc cgttcgacct gttcatccgc aagtcgccca cgatcacctg tctggtggtg     1620

gacctggcac ccagcaaggg gaccgtgaac ctgacctggt cccgggccag tgggaagcct     1680

gtgaaccact ccaccagaaa ggaggagaag cagcgcaatg gcacgttaac cgtcacgtcc     1740

gccctgccgg tgggcacccg agactggatc gagggggaga cctaccagtg cagggtgacc     1800

cacccccacc tgcccagggc cctcatgcgg tccacgacca agaccagcgg cccgcgtgct     1860

gccccggaag tctatgcgtt tgcgacgccg gagtggccgg ggagccggga caagcgcacc     1920

ctcgcctgcc tgatccagaa cttcatgcct gaggacatct cggtgcagtg gctgcacaac     1980

gaggtgcagc tcccggacgc ccggcacagc acgacgcagc cccgcaagac caagggctcc     2040

ggcttcttcg tcttcagccg cctggaggtg accagggccg aatgggagca gaaagatgag     2100

ttcatctgcc gtgcagtcca tgaggcagcg agcccctcac agaccgtcca gcgagcggtg     2160

tctgtaaatc ccggtaaaca ccatcaccat caccattga                            2199


<210> 60
<211> 2196
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 60
atgcctctgc tgctgctgct gccactgctg tgggctggcg ctctggctgc ttctctgcca       60

gtgctgcaga aggagtccgt gtttcagagc ggagctcacg cttacaggat ccccgccctg      120

ctgtatctgc ctggacagca gtccctgctg gccttcgctg agcagagggc cagcaagaag      180

gacgagcacg ctgagctgat cgtgctgagg aggggcgact acgatgctcc tacccatcag      240

gtgcagtggc aggctcagga ggtggtggct caggctaggc tggacggaca ccggagcatg      300

aacccatgcc ctctgtatga tgcccagacc ggcacactgt ttctgttctt tatcgctatc      360

ccaggccagg tgaccgagca gcagcagctg cagacaagag ccaatgtgac ccgcctgtgc      420

caggtgacct ctacagacca tggaagaacc tggtccagcc caagggacct gacagatgct      480

gctatcggcc ctgcctacag agagtggagc acctttgctg tgggaccagg acactgcctg      540

cagctgcatg atagagcccg ctctctggtg gtgccagcct acgcttatag aaagctgcac      600

ccaatccaga ggccaatccc atccgccttc tgctttctgt ctcacgacca tggaaggacc      660

tgggctaggg gacatttcgt ggctcaggat acactggagt gtcaggtggc tgaggtggag      720

accggagagc agagggtggt gacactgaac gctcggtctc acctgagggc tagggtgcag      780

gctcagtcca ccaatgacgg cctggatttt caggagagcc agctggtgaa gaagctggtg      840

gagccacctc cacagggatg tcagggatcc gtgatcagct tcccttctcc acgctccgga      900

ccaggatctc cagctcagtg gctgctgtac acacacccaa cccattcctg gcagagagcc      960

gacctgggag cttatctgaa cccccgcccc cctgctcctg aggcttggtc cgagcccgtg     1020

ctgctggcta agggatcttg cgcttactcc gacctgcaga gcatgggaac cggaccagat     1080

ggaagcccac tgtttggctg tctgtacgag gctaatgatt atgaggagat cgtgttcctg     1140

atgtttacac tgaagcaggc cttcccagct gagtatctgc cacagggagg aggaggagga     1200

ggatgctcta gggactttac accacccacc gtgaagatcc tgcagtcttc ctgcgatggc     1260

ggcggccact tccctccaac catccagctg ctgtgcctgg tgtccggcta cacacccggc     1320

accatcaaca tcacctggct ggaggacggc caggtcatgg acgtggatct gagcacagcc     1380

tctaccacac aggagggcga gctggcttcc acacagagcg agctgaccct gtcccagaag     1440

cactggctga gcgatcggac ctacacatgc caggtgacat atcagggcca taccttcgag     1500

gacagcacaa agaagtgtgc cgattctaac cctaggggcg tgtccgctta tctgtctcgg     1560

ccctcccctt tcgacctgtt tatcagaaag agcccaacca tcacatgtct ggtggtggat     1620

ctggccccct ctaagggcac agtgaatctg acctggagcc gcgcttctgg caagcccgtg     1680

aaccattcca ccaggaagga ggagaagcag cggaatggca ccctgacagt gaccagcgcc     1740

ctgcctgtgg gcacaaggga ctggatcgag ggcgagacct accagtgccg ggtgacacac     1800

cctcatctgc caagagctct gatgcgctct accacaaaga cctccggccc tagagccgct     1860

ccagaggtgt atgcctttgc tacccccgag tggcctggct ccagagataa gcgcacactg     1920

gcctgtctga tccagaactt catgcctgag gacatctctg tgcagtggct gcacaatgag     1980

gtgcagctgc ctgatgctag acattccacc acacagccac gcaagaccaa gggcagcggc     2040

ttcttcgtgt tctccaggct ggaggtgaca agggctgagt gggagcagaa ggacgagttt     2100

atctgcagag ctgtgcacga ggccgctagc ccttctcaga ccgtgcagcg cgccgtgagc     2160

gtgaatccag gcaagcacca tcaccatcac cattga                               2196


<210> 61
<211> 2442
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 61
atgcctctgc tgctgctgct gccactgctg tgggctggcg ctctggctat gagacctgcg       60

gacctgcccc cgcgccccat ggaagaatcc ccggcgtcca gctctgcccc gacagagacg      120

gaggagccgg ggtccagtgc agaggtcatg gaagaagtga caacatgctc cttcaacagc      180

cctctgttcc ggcaggaaga tgacagaggg attacctacc ggatcccagc cctgctctac      240

atacccccca cccacacctt cctggccttt gcagagaagc gttctacgag gagagatgag      300

gatgctctcc acctggtgct gaggcgaggg ttgaggattg ggcagttggt acagtggggg      360

cccctgaagc cactgatgga agccacacta ccggggcatc ggaccatgaa cccctgtcct      420

gtatgggagc agaagagtgg ttgtgtgttc ctgttcttca tctgtgtgcg gggccatgtc      480

acagagcgtc aacagattgt gtcaggcagg aatgctgccc gcctttgctt catctacagt      540

caggatgctg gatgttcatg gagtgaggtg agggacttga ctgaggaggt cattggctca      600

gagctgaagc actgggccac atttgctgtg ggcccaggtc atggcatcca gctgcagtca      660

gggagactgg tcatccctgc gtatacctac tacatccctt cctggttctt ttgcttccag      720

ctaccatgta aaaccaggcc tcattctctg atgatctaca gtgatgacct aggggtcaca      780

tggcaccatg gtagactcat taggcccatg gttacagtag aatgtgaagt ggcagaggtg      840

actgggaggg ctggccaccc tgtgctatat tgcagtgccc ggacaccaaa caggtgccgg      900

gcagaggcgc tcagcactga ccatggtgaa ggctttcaga gactggccct gagtcgacag      960

ctctgtgagc ccccacatgg ttgccaaggg agtgtggtaa gtttccggcc cctggagatc     1020

ccacataggt gccaggactc tagcagcaaa gatgcaccca ccattcagca gagctctcca     1080

ggcagttcac tgaggctgga ggaggaagct ggaacaccgt cagaatcatg gctcttgtac     1140

tcacacccaa ccagtaggaa acagagggtt gacctaggta tctatctcaa ccagaccccc     1200

ttggaggctg cctgctggtc ccgcccctgg atcttgcact gtgggccctg tggctactct     1260

gatctggctg ctctggagga ggagggcttg tttgggtgtt tgtttgaatg tgggaccaag     1320

caagagtgtg agcagattgc cttccgcctg tttacacacc gggagatcct gagtcacctg     1380

cagggggact gcaccagccc tggtaggaac ccaagccaat tcaaaagcaa tggaggagga     1440

ggaggaggat gctctaggga ctttacacca cccaccgtga agatcctgca gtcttcctgc     1500

gatggcggcg gccacttccc tccaaccatc cagctgctgt gcctggtgtc cggctacaca     1560

cccggcacca tcaacatcac ctggctggag gacggccagg tcatggacgt ggatctgagc     1620

acagcctcta ccacacagga gggcgagctg gcttccacac agagcgagct gaccctgtcc     1680

cagaagcact ggctgagcga tcggacctac acatgccagg tgacatatca gggccatacc     1740

ttcgaggaca gcacaaagaa gtgtgccgat tctaacccta ggggcgtgtc cgcttatctg     1800

tctcggccct cccctttcga cctgtttatc agaaagagcc caaccatcac atgtctggtg     1860

gtggatctgg ccccctctaa gggcacagtg aatctgacct ggagccgcgc ttctggcaag     1920

cccgtgaacc attccaccag gaaggaggag aagcagcgga atggcaccct gacagtgacc     1980

agcgccctgc ctgtgggcac aagggactgg atcgagggcg agacctacca gtgccgggtg     2040

acacaccctc atctgccaag agctctgatg cgctctacca caaagacctc cggccctaga     2100

gccgctccag aggtgtatgc ctttgctacc cccgagtggc ctggctccag agataagcgc     2160

acactggcct gtctgatcca gaacttcatg cctgaggaca tctctgtgca gtggctgcac     2220

aatgaggtgc agctgcctga tgctagacat tccaccacac agccacgcaa gaccaagggc     2280

agcggcttct tcgtgttctc caggctggag gtgacaaggg ctgagtggga gcagaaggac     2340

gagtttatct gcagagctgt gcacgaggcc gctagccctt ctcagaccgt gcagcgcgcc     2400

gtgagcgtga atccaggcaa gcaccatcac catcaccatt ga                        2442


<210> 62
<211> 2511
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 62
atgcctctgc tgctgctgct gccactgctg tgggctggcg ctctggctat gggggtccct       60

cgtacccctt cacggacagt gctcttcgag cgggagagga cgggcctgac ctaccgcgtg      120

ccctcgctgc tccccgtgcc ccccgggccc accctgctgg cctttgtgga gcagcggctc      180

agccctgacg actcccacgc ccaccgcctg gtgctgagga ggggcacgct ggccgggggc      240

tccgtgcggt ggggtgccct gcacgtgctg gggacagcag ccctggcgga gcaccggtcc      300

atgaacccct gccctgtgca cgatgctggc acgggcaccg tcttcctctt cttcatcgcg      360

gtgctgggcc acacgcctga ggccgtgcag atcgccacgg gaaggaacgc cgcgcgcctc      420

tgctgtgtgg ccagccgtga cgccggcctc tcgtggggca gcgcccggga cctcaccgag      480

gaggccatcg gtggtgccgt gcaggactgg gccacattcg ctgtgggtcc cggccacggt      540

gtgcagctgc cctcaggccg cctgctggta cccgcctaca cctaccgcgt ggaccgccga      600

gagtgttttg gcaagatctg ccggaccagc cctcactcct tcgccttcta cagcgatgac      660

cacggccgca cctggcgctg tggaggcctc gtgcccaacc tgcgctcagg cgagtgccag      720

ctggcagcgg tggacggtgg gcaggccggc agcttcctct actgcaatgc ccggagccca      780

ctgggcagcc gtgtgcaggc gctcagcact gacgagggca cctccttcct gcccgcagag      840

cgcgtggctt ccctgcccga gactgcctgg ggctgccagg gcagcatcgt gggcttccca      900

gcccccgccc ccaacaggcc acgggatgac agttggtcag tgggccccgg gagtcccctc      960

cagcctccac tcctcggtcc tggagtccac gaacccccag aggaggctgc tgtagacccc     1020

cgtggaggcc aggtgcctgg tgggcccttc agccgtctgc agcctcgggg ggatggcccc     1080

aggcagcctg gccccaggcc tggggtcagt ggggatgtgg ggtcctggac cctggcactc     1140

cccatgccct ttgctgcccc gccccagagc cccacgtggc tgctgtactc ccacccagtg     1200

gggcgcaggg ctcggctaca catgggtatc cgcctgagcc agtccccgct ggacccgcgc     1260

agctggacag agccctgggt gatctacgag ggccccagcg gctactccga cctggcgtcc     1320

atcgggccgg cccctgaggg gggcctggtt tttgcctgcc tgtacgagag cggggccagg     1380

acctcctatg atgagatttc cttttgtaca ttctccctgc gtgaggtcct ggagaacgtg     1440

cccgccagcc ccaaaccgcc caaccttggg gacaagcctc gggggtgctg ctggccctcc     1500

ggaggaggag gaggaggatg ctctagggac tttacaccac ccaccgtgaa gatcctgcag     1560

tcttcctgcg atggcggcgg ccacttccct ccaaccatcc agctgctgtg cctggtgtcc     1620

ggctacacac ccggcaccat caacatcacc tggctggagg acggccaggt catggacgtg     1680

gatctgagca cagcctctac cacacaggag ggcgagctgg cttccacaca gagcgagctg     1740

accctgtccc agaagcactg gctgagcgat cggacctaca catgccaggt gacatatcag     1800

ggccatacct tcgaggacag cacaaagaag tgtgccgatt ctaaccctag gggcgtgtcc     1860

gcttatctgt ctcggccctc ccctttcgac ctgtttatca gaaagagccc aaccatcaca     1920

tgtctggtgg tggatctggc cccctctaag ggcacagtga atctgacctg gagccgcgct     1980

tctggcaagc ccgtgaacca ttccaccagg aaggaggaga agcagcggaa tggcaccctg     2040

acagtgacca gcgccctgcc tgtgggcaca agggactgga tcgagggcga gacctaccag     2100

tgccgggtga cacaccctca tctgccaaga gctctgatgc gctctaccac aaagacctcc     2160

ggccctagag ccgctccaga ggtgtatgcc tttgctaccc ccgagtggcc tggctccaga     2220

gataagcgca cactggcctg tctgatccag aacttcatgc ctgaggacat ctctgtgcag     2280

tggctgcaca atgaggtgca gctgcctgat gctagacatt ccaccacaca gccacgcaag     2340

accaagggca gcggcttctt cgtgttctcc aggctggagg tgacaagggc tgagtgggag     2400

cagaaggacg agtttatctg cagagctgtg cacgaggccg ctagcccttc tcagaccgtg     2460

cagcgcgccg tgagcgtgaa tccaggcaag caccatcacc atcaccattg a              2511


<210> 63
<211> 2220
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 63
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ggatccccag cacagtggaa gcttgagaac gacttcggtc tggtgcagcc gctggtgacc      120

atggagcaac tgctgtgggt gagcgggaga cagatcggct cagtggacac cttccgcatc      180

ccgctcatca cagccactcc gcggggcact cttctcgcct ttgctgaggc gaggaaaatg      240

tcctcatccg atgagggggc caagttcatc gccctgcgga ggtccatgga ccagggcagc      300

acatggtctc ctacagcgtt cattgtcaat gatggggatg tccccgatgg gctgaacctt      360

ggggcagtag tgagcgatgt tgagacagga gtagtatttc ttttctactc cctttgtgct      420

cacaaggccg gctgccaggt ggcctctacc atgttggtat ggagcaagga tgatggtgtt      480

tcctggagca caccccggaa tctctccctg gatattggca ctgaagtgtt tgcccctgga      540

ccgggctctg gtattcagaa acagcgggag ccacggaagg gccgcctcat cgtgtgtggc      600

catgggacgc tggagcggga cggagtcttc tgtctcctca gcgatgatca tggtgcctcc      660

tggcgctacg gaagtggggt cagcggcatc ccctacggtc agcccaagca ggaaaatgat      720

ttcaatcctg atgaatgcca gccctatgag ctcccagatg gctcagtcgt catcaatgcc      780

cgaaaccaga acaactacca ctgccactgc cgaattgtcc tccgcagcta tgatgcctgt      840

gatacactaa ggccccgtga tgtgaccttc gaccctgagc tcgtggaccc tgtggtagct      900

gcaggagctg tagtcaccag ctccggcatt gtcttcttct ccaacccagc acatccagag      960

ttccgagtga acctgaccct gcgatggagc ttcagcaatg gtacctcatg gcggaaagag     1020

acagtccagc tatggccagg ccccagtggc tattcatccc tggcaaccct ggagggcagc     1080

atggatggag aggagcaggc cccccagctc tacgtcctgt atgagaaagg ccggaaccac     1140

tacacagaga gcatctccgt ggccaaaatc agtgtctatg ggacactcgg aggaggagga     1200

ggaggcgtga gaccagtgaa catcacagag cccaccctgg agctgctgca ctcttcctgc     1260

gatcccaatg ccttccatag cacaatccag ctgtactgtt ttatctatgg ccacatcctg     1320

aacgacgtga gcgtgtcttg gctgatggac gatcgcgaga tcacagatac cctggctcag     1380

accgtgctga tcaaggagga gggcaagctg gccagcacat gctctaagct gaatatcacc     1440

gagcagcagt ggatgtccga gtccaccttc acctgcaagg tgacatctca gggcgtggac     1500

tacctggctc acaccagacg ctgtcctgat catgagccaa ggggcgtgat cacatacctg     1560

atcccaccct ctccactgga cctgtatcag aacggcgccc ccaagctgac ctgtctggtg     1620

gtggatctgg agtccgagaa gaacgtgaat gtgacatgga atcaggagaa gaagacctcc     1680

gtgtccgcca gccagtggta cacaaagcac cataacaatg ccaccacatc catcaccagc     1740

atcctgccag tggtggctaa ggactggatc gagggctacg gctatcagtg catcgtggac     1800

catcccgatt tccctaagcc aatcgtgagg agcatcacaa agacccctgg acagcggtct     1860

gccccagagg tgtacgtgtt ccctccaccc gaggaggagt ctgaggataa gcggacactg     1920

acctgtctga tccagaactt ctttcctgag gacatcagcg tgcagtggct gggcgatggc     1980

aagctgatct ctaattccca gcactctacc acaaccccac tgaagtctaa cggctccaat     2040

cagggcttct ttatcttctc caggctggag gtggctaaga cactgtggac ccagcggaag     2100

cagtttacat gccaggtcat ccatgaggcc ctgcagaagc ccagaaagct ggagaagaca     2160

atcagcacct ctctgggcaa cacctccctg cgccctagcc accatcacca tcaccattga     2220


<210> 64
<211> 2223
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 64
atgcctctgc tgctgctgct gccactgctg tgggctggcg ctctggctga catggctagc       60

ctgcctgtgc tgcagaagga gagcgtgttc cagtctggag ctcacgctta caggatcccc      120

gccctgctgt atctgcctgg ccagcagtcc ctgctggctt ttgccgagca gcgggctagc      180

aagaaggatg agcacgctga gctgatcgtg ctgaggaggg gcgactacga tgctccaacc      240

catcaggtgc agtggcaggc tcaggaggtg gtggctcagg ctagactgga cggacaccgc      300

tccatgaacc cttgcccact gtatgatgct cagacaggca ccctgttcct gttctttatc      360

gctatcccag gacaggtgac cgagcagcag cagctgcaga caagggccaa tgtgacccgg      420

ctgtgccagg tgacaagcac cgaccatggc agaacatggt ccagccctag ggacctgacc      480

gatgctgcta tcggcccagc ttacagagag tggtccacct tcgccgtggg accaggacac      540

tgcctgcagc tgcatgatag ggctcggagc ctggtggtgc cagcttacgc ctataggaag      600

ctgcacccta tccagcggcc catcccttct gccttctgct ttctgtccca cgaccatggc      660

aggacatggg ctcggggcca ttttgtggcc caggataccc tggagtgtca ggtggctgag      720

gtggagacag gcgagcagag agtggtgacc ctgaacgccc gctctcacct gagagctcgc      780

gtgcaggccc agtccaccaa tgacggcctg gatttccagg agagccagct ggtgaagaag      840

ctggtggagc cacctccaca gggatgtcag ggatccgtga tcagctttcc atctccacgc      900

tccggaccag gatctcctgc tcagtggctg ctgtacacac accccaccca ttcctggcag      960

agagctgacc tgggagctta tctgaacccc cgcccccctg ctcctgaggc ttggagcgag     1020

cctgtgctgc tggctaaggg ctcctgcgcc tacagcgacc tgcagtctat gggcacaggc     1080

ccagatggct ctcccctgtt cggctgtctg tacgaggcta atgactatga ggagatcgtg     1140

ttcctgatgt ttaccctgaa gcaggctttt ccagccgagt atctgccaca gggaggagga     1200

ggaggaggcg tgagaccagt gaacatcaca gagcccaccc tggagctgct gcactcttcc     1260

tgcgatccca atgccttcca tagcacaatc cagctgtact gttttatcta tggccacatc     1320

ctgaacgacg tgagcgtgtc ttggctgatg gacgatcgcg agatcacaga taccctggct     1380

cagaccgtgc tgatcaagga ggagggcaag ctggccagca catgctctaa gctgaatatc     1440

accgagcagc agtggatgtc cgagtccacc ttcacctgca aggtgacatc tcagggcgtg     1500

gactacctgg ctcacaccag acgctgtcct gatcatgagc caaggggcgt gatcacatac     1560

ctgatcccac cctctccact ggacctgtat cagaacggcg cccccaagct gacctgtctg     1620

gtggtggatc tggagtccga gaagaacgtg aatgtgacat ggaatcagga gaagaagacc     1680

tccgtgtccg ccagccagtg gtacacaaag caccataaca atgccaccac atccatcacc     1740

agcatcctgc cagtggtggc taaggactgg atcgagggct acggctatca gtgcatcgtg     1800

gaccatcccg atttccctaa gccaatcgtg aggagcatca caaagacccc tggacagcgg     1860

tctgccccag aggtgtacgt gttccctcca cccgaggagg agtctgagga taagcggaca     1920

ctgacctgtc tgatccagaa cttctttcct gaggacatca gcgtgcagtg gctgggcgat     1980

ggcaagctga tctctaattc ccagcactct accacaaccc cactgaagtc taacggctcc     2040

aatcagggct tctttatctt ctccaggctg gaggtggcta agacactgtg gacccagcgg     2100

aagcagttta catgccaggt catccatgag gccctgcaga agcccagaaa gctggagaag     2160

acaatcagca cctctctggg caacacctcc ctgcgcccta gccaccatca ccatcaccat     2220

tga                                                                   2223


<210> 65
<211> 2463
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 65
atgcctctgc tgctgctgct gccactgctg tgggctggcg ctctggctat gagacctgcg       60

gacctgcccc cgcgccccat ggaagaatcc ccggcgtcca gctctgcccc gacagagacg      120

gaggagccgg ggtccagtgc agaggtcatg gaagaagtga caacatgctc cttcaacagc      180

cctctgttcc ggcaggaaga tgacagaggg attacctacc ggatcccagc cctgctctac      240

atacccccca cccacacctt cctggccttt gcagagaagc gttctacgag gagagatgag      300

gatgctctcc acctggtgct gaggcgaggg ttgaggattg ggcagttggt acagtggggg      360

cccctgaagc cactgatgga agccacacta ccggggcatc ggaccatgaa cccctgtcct      420

gtatgggagc agaagagtgg ttgtgtgttc ctgttcttca tctgtgtgcg gggccatgtc      480

acagagcgtc aacagattgt gtcaggcagg aatgctgccc gcctttgctt catctacagt      540

caggatgctg gatgttcatg gagtgaggtg agggacttga ctgaggaggt cattggctca      600

gagctgaagc actgggccac atttgctgtg ggcccaggtc atggcatcca gctgcagtca      660

gggagactgg tcatccctgc gtatacctac tacatccctt cctggttctt ttgcttccag      720

ctaccatgta aaaccaggcc tcattctctg atgatctaca gtgatgacct aggggtcaca      780

tggcaccatg gtagactcat taggcccatg gttacagtag aatgtgaagt ggcagaggtg      840

actgggaggg ctggccaccc tgtgctatat tgcagtgccc ggacaccaaa caggtgccgg      900

gcagaggcgc tcagcactga ccatggtgaa ggctttcaga gactggccct gagtcgacag      960

ctctgtgagc ccccacatgg ttgccaaggg agtgtggtaa gtttccggcc cctggagatc     1020

ccacataggt gccaggactc tagcagcaaa gatgcaccca ccattcagca gagctctcca     1080

ggcagttcac tgaggctgga ggaggaagct ggaacaccgt cagaatcatg gctcttgtac     1140

tcacacccaa ccagtaggaa acagagggtt gacctaggta tctatctcaa ccagaccccc     1200

ttggaggctg cctgctggtc ccgcccctgg atcttgcact gtgggccctg tggctactct     1260

gatctggctg ctctggagga ggagggcttg tttgggtgtt tgtttgaatg tgggaccaag     1320

caagagtgtg agcagattgc cttccgcctg tttacacacc gggagatcct gagtcacctg     1380

cagggggact gcaccagccc tggtaggaac ccaagccaat tcaaaagcaa tggaggagga     1440

ggaggaggag tgagaccagt gaacatcaca gagcccaccc tggagctgct gcactcttcc     1500

tgcgatccca atgccttcca tagcacaatc cagctgtact gttttatcta tggccacatc     1560

ctgaacgacg tgagcgtgtc ttggctgatg gacgatcgcg agatcacaga taccctggct     1620

cagaccgtgc tgatcaagga ggagggcaag ctggccagca catgctctaa gctgaatatc     1680

accgagcagc agtggatgtc cgagtccacc ttcacctgca aggtgacatc tcagggcgtg     1740

gactacctgg ctcacaccag acgctgtcct gatcatgagc caaggggcgt gatcacatac     1800

ctgatcccac cctctccact ggacctgtat cagaacggcg cccccaagct gacctgtctg     1860

gtggtggatc tggagtccga gaagaacgtg aatgtgacat ggaatcagga gaagaagacc     1920

tccgtgtccg ccagccagtg gtacacaaag caccataaca atgccaccac atccatcacc     1980

agcatcctgc cagtggtggc taaggactgg atcgagggct acggctatca gtgcatcgtg     2040

gaccatcccg atttccctaa gccaatcgtg aggagcatca caaagacccc tggacagcgg     2100

tctgccccag aggtgtacgt gttccctcca cccgaggagg agtctgagga taagcggaca     2160

ctgacctgtc tgatccagaa cttctttcct gaggacatca gcgtgcagtg gctgggcgat     2220

ggcaagctga tctctaattc ccagcactct accacaaccc cactgaagtc taacggctcc     2280

aatcagggct tctttatctt ctccaggctg gaggtggcta agacactgtg gacccagcgg     2340

aagcagttta catgccaggt catccatgag gccctgcaga agcccagaaa gctggagaag     2400

acaatcagca cctctctggg caacacctcc ctgcgcccta gccaccatca ccatcaccat     2460

tga                                                                   2463


<210> 66
<211> 2532
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 66
atgcctctgc tgctgctgct gccactgctg tgggctggcg ctctggctat gggggtccct       60

cgtacccctt cacggacagt gctcttcgag cgggagagga cgggcctgac ctaccgcgtg      120

ccctcgctgc tccccgtgcc ccccgggccc accctgctgg cctttgtgga gcagcggctc      180

agccctgacg actcccacgc ccaccgcctg gtgctgagga ggggcacgct ggccgggggc      240

tccgtgcggt ggggtgccct gcacgtgctg gggacagcag ccctggcgga gcaccggtcc      300

atgaacccct gccctgtgca cgatgctggc acgggcaccg tcttcctctt cttcatcgcg      360

gtgctgggcc acacgcctga ggccgtgcag atcgccacgg gaaggaacgc cgcgcgcctc      420

tgctgtgtgg ccagccgtga cgccggcctc tcgtggggca gcgcccggga cctcaccgag      480

gaggccatcg gtggtgccgt gcaggactgg gccacattcg ctgtgggtcc cggccacggt      540

gtgcagctgc cctcaggccg cctgctggta cccgcctaca cctaccgcgt ggaccgccga      600

gagtgttttg gcaagatctg ccggaccagc cctcactcct tcgccttcta cagcgatgac      660

cacggccgca cctggcgctg tggaggcctc gtgcccaacc tgcgctcagg cgagtgccag      720

ctggcagcgg tggacggtgg gcaggccggc agcttcctct actgcaatgc ccggagccca      780

ctgggcagcc gtgtgcaggc gctcagcact gacgagggca cctccttcct gcccgcagag      840

cgcgtggctt ccctgcccga gactgcctgg ggctgccagg gcagcatcgt gggcttccca      900

gcccccgccc ccaacaggcc acgggatgac agttggtcag tgggccccgg gagtcccctc      960

cagcctccac tcctcggtcc tggagtccac gaacccccag aggaggctgc tgtagacccc     1020

cgtggaggcc aggtgcctgg tgggcccttc agccgtctgc agcctcgggg ggatggcccc     1080

aggcagcctg gccccaggcc tggggtcagt ggggatgtgg ggtcctggac cctggcactc     1140

cccatgccct ttgctgcccc gccccagagc cccacgtggc tgctgtactc ccacccagtg     1200

gggcgcaggg ctcggctaca catgggtatc cgcctgagcc agtccccgct ggacccgcgc     1260

agctggacag agccctgggt gatctacgag ggccccagcg gctactccga cctggcgtcc     1320

atcgggccgg cccctgaggg gggcctggtt tttgcctgcc tgtacgagag cggggccagg     1380

acctcctatg atgagatttc cttttgtaca ttctccctgc gtgaggtcct ggagaacgtg     1440

cccgccagcc ccaaaccgcc caaccttggg gacaagcctc gggggtgctg ctggccctcc     1500

ggaggaggag gaggaggagt gagaccagtg aacatcacag agcccaccct ggagctgctg     1560

cactcttcct gcgatcccaa tgccttccat agcacaatcc agctgtactg ttttatctat     1620

ggccacatcc tgaacgacgt gagcgtgtct tggctgatgg acgatcgcga gatcacagat     1680

accctggctc agaccgtgct gatcaaggag gagggcaagc tggccagcac atgctctaag     1740

ctgaatatca ccgagcagca gtggatgtcc gagtccacct tcacctgcaa ggtgacatct     1800

cagggcgtgg actacctggc tcacaccaga cgctgtcctg atcatgagcc aaggggcgtg     1860

atcacatacc tgatcccacc ctctccactg gacctgtatc agaacggcgc ccccaagctg     1920

acctgtctgg tggtggatct ggagtccgag aagaacgtga atgtgacatg gaatcaggag     1980

aagaagacct ccgtgtccgc cagccagtgg tacacaaagc accataacaa tgccaccaca     2040

tccatcacca gcatcctgcc agtggtggct aaggactgga tcgagggcta cggctatcag     2100

tgcatcgtgg accatcccga tttccctaag ccaatcgtga ggagcatcac aaagacccct     2160

ggacagcggt ctgccccaga ggtgtacgtg ttccctccac ccgaggagga gtctgaggat     2220

aagcggacac tgacctgtct gatccagaac ttctttcctg aggacatcag cgtgcagtgg     2280

ctgggcgatg gcaagctgat ctctaattcc cagcactcta ccacaacccc actgaagtct     2340

aacggctcca atcagggctt ctttatcttc tccaggctgg aggtggctaa gacactgtgg     2400

acccagcgga agcagtttac atgccaggtc atccatgagg ccctgcagaa gcccagaaag     2460

ctggagaaga caatcagcac ctctctgggc aacacctccc tgcgccctag ccaccatcac     2520

catcaccatt ga                                                         2532


<210> 67
<211> 5
<212> PRT
<213> Homo sapiens

<400> 67
Thr Pro Gly Thr Ile 
1               5   


<210> 68
<211> 6
<212> PRT
<213> Homo sapiens

<400> 68
Thr Pro Gly Thr Ile Asn 
1               5       


<210> 69
<211> 7
<212> PRT
<213> Homo sapiens

<400> 69
Thr Pro Gly Thr Ile Asn Ile 
1               5           


<210> 70
<211> 8
<212> PRT
<213> Homo sapiens

<400> 70
Thr Pro Gly Thr Ile Asn Ile Thr 
1               5               


<210> 71
<211> 9
<212> PRT
<213> Homo sapiens

<400> 71
Thr Pro Gly Thr Ile Asn Ile Thr Trp 
1               5                   


<210> 72
<211> 9
<212> PRT
<213> Homo sapiens

<400> 72
Gly Thr Val Asn Leu Thr Trp Ser Arg 
1               5                   


<210> 73
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 73
His His His His His His 
1               5       



