                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  Matrix Extracellular Phosphoglycoprotein (MEPE) Variants And Uses
       Thereof 

<130>  189238.02402 (3170)

<150>  62/862,842
<151>  2019-06-18

<150>  62/806,939
<151>  2019-02-18

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  25420
<212>  DNA
<213>  homo sapien

<400>  1
tttacataaa catatgcagt gctcccctgg cctgccggca gctatccaca ccagaaagag       60

gaaaaggtag actggtaaga ctcaggcttt caagttattt caaaaccaat agcaaagtaa      120

gacctgaggt acatatagtt tgaatttagt cttttgaatg ccttttaaga gagttttgaa      180

atcagattaa gacaagcaag tgggcaaaac atgtatgtgt gctgtttttg gtcattgttg      240

ctgctttgtg gaaatgaaaa gaaaatcctg aatgatactt gttatttatc ctaatgtggc      300

cacctagcct cgtgatgaca gtaccatctg gctcctagtg aaagggaccc tgaggccccg      360

taagcctgca agggtgctcc atacaaatag aagcaggggc aaccagattt catagtcccg      420

taaggatggc ccaagaagag aagttaaaga cccctgagca ccataaagct gcaggggagc      480

cctcattcac acagacagca gctgggcacc ataatcccag cgtgcacacc tcatatatgc      540

agcacaagac cacttacgaa agcaaccaca aatggccaac acagccctta cctgatgcct      600

aaccaactag cccacacagt gcctgccaaa ccaacaccca gcactgtctt tctccaatgt      660

aggacaaaga ctgtgagtct tggctttaaa aaaaaatgtc tcacccgact ttcccgccaa      720

gtcttacctc ccaaagtcta tcctctcttg gttgaaatgg atttccttct tggcagtaga      780

acttccactc aacactcagt gcttagtctc agagtctttt gattggcgta ttatttcata      840

tttttaagct agtgggaagc ccaatcacct gactcatcat gctttccagg ataacccatc      900

tagttttgag taacttggat aattggggtg ggttttgtaa tctccacttc tacccaagtg      960

cagactccca ggactttccc actcacaacc cgtcaagcaa ttaagtggtc cccgggcagc     1020

agtgtggttg gtaactgggt tacgaagctc ctgaatgcag ctgctaggtt cacacaccac     1080

acttccacag attcagccag tagggggacc atgaagtcaa atacagtcag acattttatt     1140

acatacacaa aaaacataag catcacctgt atggtgtcag ctccctgcat ctctaattcc     1200

atagaatgac actgaacaga gaggccagat gacagatggc acaggtggta ggtcgttctg     1260

ctactgagga gtcagctcta ccccttagcc aaataggtat actcacaaag aagtctgcag     1320

ttgaacccta agggagcaag gtcaaaagtc ctgtgctcaa ctgaaactaa agagacgaat     1380

gagaaatggc cttgtggtca tcttccacaa ggtagggagg tgggtgggaa ctgcccatgg     1440

catctcttca ccagcttgct tatcctttcc tgctgcagga ggaattgcag ggtactttgc     1500

caagactcag gttgtactgc agtcaattct ggtcccatat gtaatccata aagacatggt     1560

tggtatggag ttgtgcaagg ttgtcaggaa gttgcagcag agcagctccc ctgaatacct     1620

cttccagatc tcaaagtttg ggaagcattg agtgtcctgg acgtttcaga aggaggctgg     1680

ccacatagga gtgtggactg gctaaaaaaa gcttttgacg catcaaagag ggtgactctt     1740

acaagataat tcatggtaga catgcaggac ctcgccaggc agtggtgtgc tcaatggctg     1800

ctcacccact gtgtgggtgg atggtctgta ggtatcagcg tggccacagt gtaactgctt     1860

ctcaaagatg actctgccct tttcccagga tcaccctgta ttttgtcctc tcatttcaag     1920

tccttcttac ctccttcaac acgatgactc aatcaatatc ctctgcagct ggtagcagac     1980

aggatagcag aggggaccca tctttaatct gtgaggctca ctaaatatcc ctctcctttt     2040

cagtttatta ttgtgacata aattctatgc cctgcatcct tcatagttgg ccatgttgat     2100

tttctaccac gctttcttta accaaaaagg taaaacaaac aatacttttg caaaactaaa     2160

gctttagctt tcaaaatgat tgtttctgat gcgggcttca agagtctatt tcagcagtaa     2220

gaaaacaaat gttgactttc ttttcatttg gatcctttct gtcaaaaact ccaatccttc     2280

tccaggcaaa gtggatctct ttgaatgatg aggagaacaa atagtggaag tgtgagaaag     2340

gcagaaaagc atacacactt ttttcctttt cttttgaaaa ggaaaatcta aagtaaagaa     2400

acatgaatct cgggttaaaa aaaagaatca acatcaattg aaagtaaacc atgaagcaat     2460

gacttggaca ttttgtttat ccatgtacag tgtagcaaat attttctgcc ctagctcttt     2520

aaaatactta gtgggttaga aactcattaa cttgatttgt tggttgaaga ataaaggttc     2580

tcatgcaaat tacattctgt tacatcctgg tctttctcag gaggcttctc ccttgtatct     2640

catggttccc agggtccagg aagataagac caccattaat atgtacagaa ttcatcttat     2700

ctctttttaa aatataaatt ctgccctcac tattttaata aggggtcagc aagctttcac     2760

taaaaagcaa aagtcagcaa acttcttttt taaaagacca gatagaaagt attcttggct     2820

ttgcagaatt tgtgctgtcg attttacaga actaacctac agctagaacc aagatcaagc     2880

ttcccctcag ctggctaagt ggtgagacat acctgatcat tcttgttaca gaattctgaa     2940

agacagtata gtgaaaaagt tacctttaaa tattatttat caaagataat acttcttgct     3000

gtgcctaggt cctggaactg tcagaaacat caaatagctg cagagggtgg attgctttgc     3060

aggctatatg gtttctgtca caattactca actctgacac tgtagtgaaa gcagccatag     3120

acaattcgta aacaaatgaa catgactgtg ttccaataaa actttatctg ccaaaacagg     3180

tgatgagtca gatttggccc acaggccata gttcactgat ccccttttag atgattgtat     3240

aaactatgat cattttgaaa atgttgttgt cattaatcac ttaagagata aattgtatct     3300

ttttctcttt tctttgtgtt ttttttgttt gtttgttttc aatttgaagc tttgtccttt     3360

gcttcaaact ttgtttaaaa actcaggaac atttctgatg tttgatagag caacctgagg     3420

attttctcct ttctgcagct acatatttat gtattagttt tattttttga gacagggtct     3480

tgctctgtca cccaggctgg agtgcagtgg tgcaatcaca gctcactgca ggctcgacct     3540

cccaggctca ggtgatcctc ctgcctcagc ggccccaaga gctgggacta caggtgtgca     3600

ccaccacacc agggtaattt ttgtattttc tagtagacaa ggttttgcca tgctgctgag     3660

gctagtctcc atctctggct caagcaatcc accctctgca gctatttgat gagatgtttc     3720

tgacagttcc aggacctagg cacagcaaga agtattatct ttgataaata atatttaaag     3780

gtaacttttt cactatactg tctttcaaaa ttctgtaaca agaatgatca ggtatgtctc     3840

acctcttagc cagctgaggg gaagcttgat cttggttcta gctgtaggtt agttctgtaa     3900

aatcaacagc acaaccatta ctcctgctac ataaaatggg ccatgatcaa atccagtaca     3960

ccaaacattc tgagaataac tgtcagtgaa tgcccaatac ctgaattaca cccggggtat     4020

gtcttaggca cactgtattc tccaaaaatg actgaaacgt tatctcccat tcctcaagct     4080

attctgcaat gtgaggctgc cacttctcca tcaaggtgtg aggcctattt ctgcacccgc     4140

ttcaatctga cagttttgac gaacaagtgg agagtaactg tgcaacagtc ccaggcttag     4200

gccataaaac tagcctgtca atctctgctt tcaatttgca tggaaacttt tattcttaga     4260

ccaacaaatc cagttaatta atttttaacc gactatcttt ttttcttcaa cttttaaggt     4320

ctgtacatgc gcaggatgtg cgggtttgtt aacgcaggta aatgtgtgtc atggtgattt     4380

actgcacagt acctcctatc gcctaggtat caagcccagc atgcattagc tattattcct     4440

gataccccac ctccaacagg ccccagtgtg tgtttttccc ctccctgtgt ccatgtgttc     4500

tcattattca actcccactt ataagtgaga acgtgcagta tttggttttc tgttcctgca     4560

ttggtttgct ggggataatg gcttctggct ccatcgatgt ccctgcagag gacatgatct     4620

cattcttttt tatggctgca tagtattcca tggtgtacac atgccacatt ttctttatcc     4680

agtatatcat tgatgggcat ttatatcatt ttctttatcc agtatatcat tgatgcacat     4740

tcatgtcttt gctattgtga atagtgctgc aataaacata catgtgcatg tttctttata     4800

atagaatgct ttatattctt tatattcttt tttttttttt gagacagagt cttacgctgt     4860

catcaggcag gggtgcagtg ccatgatttc cactcactac aacctctgcc tcccgggttc     4920

aagggattct cctgccttag cctcccaagt agctaggact gcaggtgcac accaccacaa     4980

cagttttttt ttttgttttt gttttttgtt tttgtttttt tttgctagag atggggtttc     5040

aacatgttgg ccaggatggt ctcgatctct tgacctcgtg atctgctaca ttcctttgga     5100

tatataccca gtaatgggat tgctgggtca agtggtattt ctgcctctag gtctttgagg     5160

aattgccaca ctgtcttcca caatggttaa ctaatttata ctcccaccaa cagtgtaaaa     5220

gcattccttt ttatctgcag cctcaccaac atctgttgtt tttttgactt tttaataata     5280

gtaattgtga cgtgtgagat ggtatctcat tgtggttttg atttgcattt ctgtaatgat     5340

cagtggggat gttgagcttt ttttcacgta tttgctggcc acatgtatgt cttcttttct     5400

aaagtgtcta attatgttct ttccccactt tttaatgggg ctgttggttt ttgttttttt     5460

cttgtaaatt tgtttaagtt tcttatagac tctggatatt agacctttgt cagatggata     5520

gattgcaaac attttttccc attctgtggg ttgtctattc actcggatga tagattcttt     5580

tgctgtgcag aagctcttta gtttaattag atcccatttc tgactgagca ttttaaatcc     5640

tgagctacca tataggaagt ccagcctatt ctgcaggaca gagtgatcat gtggagaagc     5700

actgtggcat atcggatgtg cagctcagtc aagttttggg atgactcttg caccccatct     5760

ctgactgtgc catttgagaa atcacaagtg agaatcatgc agctgagcca agtcaacaca     5820

cagaaccttg agagaaaaca gtgaatttgt atttcaaact acgaaaagtt ttaaggtggt     5880

atgtttatag caacagataa ctggaacagg aactgacaag catagagaaa atctgggttg     5940

gtgagaatta aggaattcat gaaaaaagag ataaaataaa atgataacac aatgcagata     6000

aacatggaat taaaaataag ctaagacgat atacacccta atttggtaag aaaatattaa     6060

tacatgttcg atacaatgaa tagctagctg gtaaaagtcc tcaagttctg tatcctgaga     6120

agaagattct tggtcttgaa aaacaaaaca gcaacctctg aaaaagacta ttatgagggt     6180

aagagatatt ttcctcttga ggtcacacaa caaagttttg cagccacttc cagcaatgtc     6240

accatgtcct gaaggaaagg gctagcatca ttataattat attttaacta catcctctga     6300

gttacatttt aaggtggagt aagacatctc tctaatataa aaataaaagc aaattatatt     6360

gacatgtctt ctctttgctt gtaatagagg aatgggtaaa caaaaagccc agaggaatga     6420

acacagctaa cttcatgctc tgctgtgacc ctccatgatt ctgcatctgg ctgaaatttt     6480

tatggcttct gttgaaattc ccaaatgctg acagaaaaaa taataactaa aaataaaatt     6540

aatttgaggg taaaggagaa agttggttgt aagtgatgct ttagaaaagg tgaccttttt     6600

gagcttagga tgattattga tactcatgaa tgaacacgtt taaaatgaaa acattccttc     6660

tgctaaaaac agggcaagac tcccagcaca ctcattctgg actcttattt tggatatcag     6720

tgggaagtaa atacttctat gaaatgccta aagccttgac caatctaagc atctgtatgg     6780

taaagaagag attactcaac atggacccct ctgttctatt cacaacactt caaagacttc     6840

cccactgatc caggagggga aatactgtat atttgtaatg tatgtaaatt agaagataga     6900

gagttatttt ggcaagttag aacatacaga aaagtatatt gtatatgtaa aacagaaact     6960

tattttagtt agaacatatg gaaaagtgta ttgtgtgagt ctgtctaaaa tgatgacaga     7020

gaaatgtgtt accttaatag agtcaagaat aaattgggga ccatgatagc aggggaaaaa     7080

ggacttccta gaatactaag tttaaaaaaa aatgtatacc aaagcaatta atcccagagc     7140

acaagtacag aaaagatggg tcctagaaat agatgagaaa ataaaacaaa caaacaaaaa     7200

agccttattc ctgggtgaga gtctaatagc tggaactgat agtataggtt cctagttagc     7260

tagcatttta tatgattgtt cacactcaag tgatcgataa gaaatgaaaa acccacgaca     7320

ggatgaagca tgttccatgg agtacttcct tccagattct ctttgaggag caactctgtg     7380

tgtcagtctg acccagcaaa gtcaggctag gtgcatcatt ggtggaggtg tccatttttg     7440

aaccaggaac gaggaaccag aaaaaagttc aagtgtccat ttctttccct tctcagttgt     7500

ttcccatttt tctttgtttt gttttgtttt ccagttaaat agagatggtg tgaagataca     7560

tatttttttt acagactcct ggttttaact tcagttattg gttccttaga aatgccatgg     7620

caaaactctc tattatacaa taacctttag gaaacttata ttgagttttt gaagttcaat     7680

ttcaacacag agggcaagtt ttaagagggt agaagtaaaa atctctactg catggaactt     7740

aggcaaagga tcattctcct aatttttttt ccccagaatt tcttctctgc aaccttctag     7800

ccagaatagg ctctcatttt tttttgcttt tgtcaattgt aggttctaaa tttaaaactc     7860

aagttgaatt tttttatgta gctttgaatt cattttagct ttgagagcag tatatttagc     7920

tactgccagt tcaccccttg gtaggactag tagctaagcc agtttttttc tcttaaaact     7980

ctataaattt tcttatccta gaacacaggt ttttctagat cataattaat tttccatcac     8040

tcaaatgaaa gggaaatctt tttcatgcac actgaaattt atttgaaact aagaaaaatg     8100

catttgagga atatctgaaa ttatttataa aattatagca ataaaaaaat gaacatttcc     8160

taaggcacat atcaagtgtt tgctctataa ctggatcatt caaaatataa agttaatgtt     8220

atgaaacagt gtaacagctt aaaacactgc attatataca cattattata gaaattcctg     8280

aattatttat tgcttcaata gcatatccaa agttgaaaat gagcattttt tgtggatttc     8340

acttgtcttc catttagaaa gctctatatt tccattcagt ctcagagttg gctgaacact     8400

ctttgttgcc ttctttcctt ccttgacttc cattcccttg ttagctcctt tctatatcac     8460

ccaaatcctt tttttttttt tttttggact ttgctgaaat tctggtcatg gatactgtgc     8520

tccttatttt cagttggaga aactgaggca cagaaaagtt caaattagtt gtttaatcaa     8580

cttgccacag taaacaggtg gtagagtcag gatttgaact caagtctgtt tgcctccaaa     8640

gctactagag ttctagagtt caatatttcc actgtcaatg acaatattca aatattctaa     8700

aatctatgct tgaatggttg taagtcaaca gtggccccac ccaatagctc aaacctagtc     8760

ctggaagatg ttcttaaaag cagttctgta aaagcagaac tactgtttga tccagtaatc     8820

ccattactgg gtatataccc ggaggaatat aacacattct tccataaaga cacatgcaca     8880

cggctgttca ttgcagccct gttcacaatg ggaaagacat ggaatcaact taaatgccta     8940

tcagtgacag actggataaa gaaaatgtgg tatgtataca ccatggaata ttatgcagct     9000

ataaaaatga aagagatcat gtcctttgtg ggaacatggc tggagctgga ggccattatc     9060

ttcagcaaac taacgcagga acagaaaacc aaataccaca tgttctcact tataagtggg     9120

agctaaatga taagaactta tgaacacaaa gaaggaaaca acagacattg gggtctactt     9180

gagggtgaag ggtgggaaga aggagaggaa cagaaaagat aactattggg tactgagctt     9240

aatacctggg tgatgtagta atatgtacaa caaaccccag ggacatgtgt ttatctatgt     9300

aatgaacctt cacatgtacc tccaaaccta aataaaaatt tttttaacaa gaagacatga     9360

ggtgagggag aggaggaaaa gcagctctgg atactcaaaa gaggaacagc agaatttaga     9420

tatgataaaa aaaaaaaaag agagagttag cttgacctag aaaaggcacc attttctcag     9480

gtagaactta tgaaatactg ttttgtttgt gttttatgtt ttggtttttg tctatttgga     9540

gggttgagat aaattgacag tttacactta aatcttatta tatatcattt gtatatataa     9600

tatacaactg ttaaaggtgt gtttcactgt aggtagttct tatcacaaag tataggttaa     9660

ataactctta cataatttct tattgatgct ttaatatata gtcataatgt caatgacctt     9720

tacaggtatt ataatatttt tatattaagt ggaacctctc aaactattac aattattttg     9780

gtagccagtt tgggcaaaac aagagagcag gcaatcgcac tggaaaggct tattctagta     9840

taggtttgtt acttgtttca ttaagaaatt gagtgtctta aattgtccat cttataaaat     9900

ttgtctaaat ccaaactcac aatattttcc tcaaaaccat tttcttctgc attttttcca     9960

atatgaagaa aaaatcaact ttactcttcc agttgctcag gtcaaaacct tggtgtcatc    10020

ctgattcttg attgttttct cacaggccac atctggtacc tcagcaaatc ctattaccat    10080

ttttccccaa acttcttcag aatatgacca cgtctcatca tcccttctgc cgcactcagg    10140

ttcaagcctc catcatctct ggctgggatt attacaagag cttcctagcc attctctctg    10200

cctttttcct acttcagtca ctcctcaatc atgcctgtgc ttaaaacctc caaggacttt    10260

tcttctcact catagcaatg tcaaaagcat tgcaatgacc tacaggtcct ataccatctg    10320

ccatctaata cccttctgac ctcatttgtt gctattcccc ttgctcaggc ctccaaccaa    10380

agtggcctct tctctgttcc tggaacaagt cacaaggctt ttatttctgg ggcactattt    10440

ttcttatttc ttcttcctgg aatggtcttc ccatagacag tcatatggct gcaggcttat    10500

ctgagtctgt tcatgctgct actacagaat accacagact gggtaattta taaaaaacag    10560

aaatttattt cacacagttc tggaggctgg gaattccgca atgaagaggc cagcatgttc    10620

attgcctgac gagggctgtc tatctcttct tccaatttgg caccttgcta ctgcatctcc    10680

agaggggaca aatgctgtgt cttcacactg cagacaagca gaagggcaaa aagggactag    10740

ctagtttctt cttgcccttt tataaggtca ttaatcccat tcatactggg gtctgccttc    10800

atgacttaat caccttctaa agagcccatc tctcaatact gtcaccttgg gtttaagttc    10860

taacatggga attttggagg gacacgtaca ttgaaaccat aacaaggtct ttactcaaaa    10920

gttgccttct cattgaggcc ttcccaggac ttcctatcta aaatttcaac ccagtgtccc    10980

cacccccaat gcttgttact ccccaacaat actttttctc cttagactta gtatatgtca    11040

ctatctaatc tatttaactc atttatcttg tttattatct gtctccctta ttggattcta    11100

agctccagga agacagggat ttttttctgt cttgttttgt tcactgcagt ttcgccaatg    11160

cctgtcacac agtaggcacc taaaacattt ttgttaaatg ttgctgaatt tcacttagat    11220

aaaattgaca tcataaactt tctacataaa aggatagcaa aaatgttttc catttctaaa    11280

cttgttaggt attcagtcag tcctaattag cagttctgaa atcaattttg attatctgac    11340

aacatgatgt ccaaactgag gtatttatat tttctgttta tcccactttc tggaacattt    11400

gatagtagct ttctaccaca aacacatttt tagattaaaa ttacttcacc ccctatggtt    11460

atctgtgggc gcttgtaaca aattgtttgc tagcgctgag tgagccagtg ctgattggcc    11520

attgggaact ctaacaaact ttaaatttca gcaaaatgcc cagagacttc taatcctgca    11580

acaagaagcc aggtattctg aaggtgaaag ataccaggta atttggcttt catgttcttg    11640

acagcaaata gctttatatc atagttgttt acgtttttaa gatgcttgcc acccaagtat    11700

ggttttatta cttttgaaaa tcttctctac tgagcaaaac tgtgtaatat ttggtgcttt    11760

gttttataaa ataggaaatg cgttaccatg ctctagaaat catcaactaa aattgatgat    11820

ttgatagcaa ctttctcttt ttttttgtta ttagcattat caagatccac agtaactcag    11880

acttcagttt tcttctatcc cttcacttaa caaactgcaa tcaggaaaat ctgatcttat    11940

tcatactttg aaacctcatc tgtgttgata tttctactga tgagcattaa ctcatttcat    12000

aagttactta cgttgtcctg atctataaaa tgcttggaag ggtaaactat agttagaatt    12060

tagatccttc taattgcatt aatttagaaa aacatagcct aggattttag aatatattta    12120

atagttacaa tcatttctcc aaataccagc ttttccttga ggtgtttaaa gattgcaaga    12180

atatttagat tattttttcc cataaaaaca agtttttctt caagaaatct cagagtggca    12240

taaatttatt gttttcacaa tataataata agatcaatag tccaaagaca tgttgacttt    12300

tttccaatct aatggctact taagtgagct cactagttcc tgttggtata tttaccaaaa    12360

tataaacaaa tacctttatt tgtaactaaa tgttagtatt ttgaacatca ttttgttgag    12420

cccaatataa aatatgattt gcctttaagt caactgtaca tggatttttc tgtaataaga    12480

taaaagaata gaaagttatt taaggtggca gagagtcttg atgaagaaaa ctgggtctag    12540

agccacattg cctggatact aatcccagtt ctgcccctta atatttgtga attctaaagc    12600

aagttatttg atctttttgt gtctatttcc taatctatac aacaggcata gtaacgccgc    12660

ctaacttgta gggttgttgt gaggctcaaa taattgaatg catgcaaaat tcttagaccc    12720

agtgcttggc tcattttagt attcaataaa tgttagccat taatgtcagt gttgcaaaaa    12780

ttagttcact ctccagccca tggatggcta ctaattcaga cacattgcta atgaacatga    12840

gacacagatt agggcaccag cccggaggca gataagcttt cctcacagtg caatctgcta    12900

ccctgacaaa cttagagtgt gttatgagct gctacatcaa cttaatgtca ttttgaatta    12960

cacaaataat taaacaatct ctttctaaag acaagaggaa gaagagctga tgatagagca    13020

aataaatgtg tctataaaat atatttctat caactgactt tactgtttta atgatattga    13080

ataattttca ttttcacatt ggaataacta gacatatgaa agttcttaaa atgtccacac    13140

tcgggtataa gcaagttata catagtctat acacacacat acacaaaagg atatgaactg    13200

ccaaggggaa gggtgtttat atattcctat gtgttttatc tcttcttatg gctgcagttt    13260

ataactggca atgctttgtg gtaagatatt gttgtctttt tacagagatt ctcaaagatg    13320

cgagttttct gtgtgggact actccttttc agtgtgacct gggcagcacc agtaagtatt    13380

tacaaattca attatatttc agataatctc ttgctctctt catttgtttt tctttcaagc    13440

aacgtctatt taaattagta gcatctacct aattcagtta ttttaaaaag aaccaagcaa    13500

acagaaagca tctagcactt aacactctta acaaaggagg ttctcaataa acatgtgctg    13560

aattatgaga tctgacaaca ttgtctttta aggaacacca aaaacagatt ttttgagaaa    13620

accaagaggc agccgcagca tttcaaatca gctgatacta atgagtgata ctcaaagact    13680

caaattataa catggtaaaa taatctttga ctattttcct gtaaacttaa agaatttgac    13740

atgaatgttt taaagctaac cagctagatt tagtaaatag ataaaaatgc aaagagacaa    13800

gaactcttct gtatttcttg caacacccca atactgtggg atcctacttg tgattttctc    13860

ttcatcagcg aggctagagg tgggacgtag tacctccaag cttaacccaa atcaagctcc    13920

tacttccttg tgtgtctttt cttccctctg actcacccag ttgaatattc aggatgtgac    13980

caaattatct tgtgaaaatg ctgagtgtta gttattttct gcaatgcaga cacagtgcta    14040

attagataat gtctgagcag catcctaact tatcagaata acctttttgg ttggagaacc    14100

atggaaacaa atagtcatcc cattgccaat catacttata tataggtcct gagtgagtgg    14160

gtgactgcta gggtaaccag gctgatgagg atgaccaggg aagcagaggg cctcatggag    14220

ggcagtggaa gttggggaaa tgtgttccct tctccgcaca cactctgtgc aacaagggtg    14280

tgcagtacag tactgtggag gctgtactgc tcacaacaca catttgcgag accccatgca    14340

cagacctcac tcaatcaagg cctagaggct caggtgcctc tcccacctct cacggtggaa    14400

aaatgagtct tgctgaccta gctcaagttg gccagctgaa gattttattt tgagcaacat    14460

gttccaagaa gcagctggag tggggctttc tcatcatttt ccagtaaatg tgctatgtca    14520

acattgattc agtgaccact gatcagaaga ggatgccagc tttcctgccc agaggcagac    14580

aatgccatct ccattacagg gccacattca agcctaagac atctgcttgg gggtatagag    14640

gggacaaggg agggatgcgt atttcaaatg aaagcagctc agcaaggatg cagaggcaac    14700

atttgtaact gtgaatcatt aaatatgatg ttttcttcca ggtatataga tgccatttta    14760

gtaattacct gaatttttaa atgatagatt ggtggcttaa gaaattagta tatactcagc    14820

cacttgcata cgtcttagaa ttataagcca aattctaaat gatttttaaa aggaagaaaa    14880

tgaatgttta ttaggctatg caattcggtt aatattcatc aagatgcagt tagactagaa    14940

agactttgtt ataagtcaca ataaatcaaa actgtaccga ggtactctat attgtcaagt    15000

atgtttctaa tccatatgtg tgtgtgtgtg tgtgttctgt aagaagatcc ctgacacccc    15060

atactatcat ttctttcttt tgcttaatat ctgcccatct catttttatg ctttcttctt    15120

cctatagtcc aatttccaga actgtttgcc ctggttttat atttttgaag agtgatataa    15180

ttgtccaaat ttatattcac atgatcatat aagaatcaac ataagaaatg caataaagga    15240

taaaactata aaagatgcct tgacgataat taatataaag tttaggaaca tttcctctta    15300

ttactaaatg ctttttcata tttaatcatt caaaaattta ttattttaac cctgggactt    15360

tgaggcagaa gatttaaatt aaaatatctt ctctacttct actgcaacta ccaactatga    15420

gtgtaggcac ttctgtttct tctactgctc atcttataaa ggttactttg ggactcatat    15480

gagattataa gtacaaaagc agtttacaaa ctataaagag tcctataaat agaaggtgtt    15540

attgataaac tattgttatt ttctagaatg gaattgaata ttaggcagct atgccttgga    15600

gtccagccat ggaggtgctt tctaaacttc tgagttttat attttgaaga tgattttatc    15660

tgccagagtc cagtccagaa aacaaaatcc actacaggga gctcagtaga gcgactttct    15720

aagggaagct agctataaag tataaggaag aacagaaaag ccaaccaggg gtggtgagac    15780

cacccaagga tcgaagctat taccaggctt agggctggaa ggaaaaaaaa aggtgctgct    15840

cctaggcccc tggctggggg aactaggacc acaaaggaga tgtacccaac tctagagatg    15900

cagccccaaa cacggagagt agagaaggac ataccctggc ttctctctcc ttccccccct    15960

ccagactcat gccaggcctc cttcacccaa acccagtctg aacacagagg gcaaatgagc    16020

ttgggaaatg aaggaatcag ttcagattga gctggagata caaaggagct gagagcaagc    16080

aggggcattc ccaatatctt agtgcaagca acaacctgtc tgtattaaac aaaatataga    16140

agcttaaggc ttcttcagga agaacacttt ccaggtaaat aggacagctg gcctaggcgg    16200

ccctctttct gtttatctct ttattcaatc tttcccttaa ggggttctct cttttatatg    16260

attgatccac catgatgcct gcttccactg tagcacaccc attcaaacac ggcccagtcc    16320

gcccattggt tcccagtgcc acatctgaga taggctagga gtttctgaaa gaaagaggta    16380

aatgaaaaat actgagaatt aaagaactta catctattcc tttaataaaa cagttgctct    16440

cagattttag ggtccctgtt ctgtgtgctt tcctgtggta tgcaaacttc agcccaaagg    16500

actgggacaa actgccgagg tctgttcttt cttcatttct gccctttctg cgcttcaata    16560

gctacccctc accctacgct accctcaaga aattttgaca ctttatgtca aaccaagaaa    16620

cagaatttat cctaatctgc tggccacctc catttttcct tctcagaatg taacatctgg    16680

cagcaataag tttttgtcct taattgcgat cctaccattc acatgaacgg ctatggtttg    16740

actctccctg ggccatcagc agcatcatat cttaattcaa tattacagtt actcaactta    16800

tataattaat gcacacacac aatttaaatc gtcaaactct gattttagtt cacttatatt    16860

taacaactcc cagtttgcca gtgaaaactt ctttttcagt ggattctgat ggcagccaag    16920

ctccttcgtc tggggtgcca tccctcccta ctcccccacc acacccactt agcggttgtc    16980

tgagcttgaa tccagttctg tagtggagac ggcactgtct ccctctgggg gcagaaagct    17040

ggcactgtct ttcgtaatat tgaaacaaat attatattaa tgcgatgagt gtgtcaatct    17100

tcttttggtt agaatgattt tccacagtga ataatacaac tcagtgagag aaaaataaat    17160

gaaacatttg tttgaagaag ttaatgaaat agaatgttct agtgggtgaa gttttgtttc    17220

ttgtttcctt tcagacattt caaccacaga ctgagaaaac taagcaaagc tgtgtggaag    17280

agcagagggt aaacagaatt catcttttca aataactcta tttcagctct ataaagaaaa    17340

agtcagtaag agaaaagtgt aactgtcaaa atagtcttgg gcactttgaa tggaagtgaa    17400

aaaatataca acataatgtt ggcactttct agtcaatcag gtattgtaac tcacacacca    17460

tgtgtgacag aaaagaggaa aacattgtga atagagattt atttctcccc agtatgattt    17520

cttccttcaa atgaaacaat gctttgccag gcaaccttca tggggctaag tgagtaagaa    17580

tttgggaaca ttgctactag caaacaatat tttcccacac atgtacctga caaacacttt    17640

gctctcagaa tgataaataa gggagtaaag gggaaggtgg ctatcagatc tgaatgggga    17700

attctatgtc cgtggagtca gctttccata tgcatccagt taaatgaatc ctccccgctt    17760

tgcatgccac caaattgcag cttgcttctg cctatcacag aaaattatgt tctaagaact    17820

aacaatcttc tgtacttcat ctcagctgaa aattacaaag gccaacgttg ccagcttaag    17880

agcctgaatg ttcatgctgt gagttttgcc aattagacat cagacatgaa tattgtaaat    17940

cctgtctttc tcctggtcct ctcaccccct cccacctgaa aatatttcca catgctccat    18000

ttccatagac gtttggtaat aaaatcgatc caccctagga cagaaagcag ttgacaggcc    18060

cttagggaaa acagatttag agttatgtag aaaagagaag gaacaagttg ctgtcttcgg    18120

gagccggctg acacacaccc tcctgtggtt ataagaagta ctaccatttg tcagaggtag    18180

aattcaactt cacccaactt ttaaagtttc ttatattatt acaaagagcc caaaaacttc    18240

tttgtaagag ataaaacgtg cctcaatata atgttgtgtt tttgtagata acatacaagg    18300

gtcactatga gaaacatggg cattatgttt ttaagtgtgt ttacatgtca cctgagaaga    18360

aaaatcaaac tgatgtaaag gtaagctgaa tctctgaatg accattctca gcatgactaa    18420

actctggact agccctagag gaaaatgtag gggaggcaaa gtttactttt gcttgctctg    18480

gggtttctgt cttatggctg gcacttttgt cccttccctc cctccccagg ctcctcaagc    18540

ctctctacta caaaactctg ggtcccagaa tcttcctgat ccccatccca tgcctcggcc    18600

cacatctcgc tctgcttcag gacctgtggc tgcaggtgtg atactcatgg acctcaggtg    18660

cccatggact gctgtgttac tgcttctgag taacatttgg tgttttataa gaaagttttc    18720

ttgacatatt ctaccatatg ctctgatggt ggggatctca gcaggggacg gctaagagga    18780

aaaaccattt tggcctaatg agtgacacat tttactgtct cttaaattca ttctatggat    18840

aactccatct gtgttgggtt gctcagaagt aaaagaatga ggcccttgtc actacaatga    18900

caataattct tttcactcag tcccttcttg tagattcatc ggccaaaggg ctggaaatag    18960

cttgaaatgc catcagcaaa agggctattt actttttcca aatctggttt tatttcccat    19020

ggaagtaata gtttcccttc agaatgttat tttcttctgc catcgatatc ctttagatga    19080

catctctaag actacaccta actataaata agttaaaaca tatccatttg ccaaatatat    19140

gtggagttct taactggtgt gtaagatact atgtgagata aaatgatgga gaaaacaaat    19200

tctttctctc caggatctta gagttagaaa agaaacaaaa ggcacttaca aaaattattg    19260

taaaacaaga cagaatgtgg gaggtgctat gtgagtagta ccgagaagaa aaaaaagatc    19320

atgctttaag ggcttggagt agaaagaaat tagttcctgg cctctggtgt tcataatgga    19380

aataattgtg tggggccatg gaggatgagt aggatttgag caaacagaag tgaatgggtg    19440

aggccgttct ccatgaaaaa actcatagga accaaagcat ggagacagaa aagcagagca    19500

cagaaaagca gccagccaac tggtacataa accatcgaac agtcagaaat catttaacac    19560

aagcaaatgt aagaaaagtt tttttctatt ttttgatatt ttcttcaatg caaagatagc    19620

catcatatac cacaggataa aagttgtttc atgttttcat ttataaaatt attctactca    19680

gtcttctaat aaaatgcaca caattcatta gtgtacatgt tactttttta aaagcagaga    19740

agcaccgaaa ataaaacata acttcccact tcagacaagg gagagaaaaa attaggaaga    19800

gattattata atctactgag tttagattta gtgtttaact caaaaggtta tcttagtaat    19860

gagtaaacaa acaacaatga acttgattgc aaaggaaaac ataaatgtcc aagtaaaact    19920

ttccaggact caattactca agtcaaatat ttaaaatact ttttatttag tgatatacta    19980

caaagtttat ttctattttt ttcttatggc aaaatcgtat ttcagaatat acccaccaat    20040

attaaaaaat taatgaacaa taatgccata acttttacaa ataagtaatt tcaaattata    20100

ttttacaaat attatacatt ggcacttttg cagaccatat attagctagc ttcttaaaag    20160

tagagggcac ttctaaaagc catttttatt ttagattcaa atgtgagctg attcaacatt    20220

tccgcctact tccaacagtt aataagatac atatataaaa gcagacagtc ctccaagcag    20280

aacagtactt ctgtttggga gtgaaaaaaa agagagagtc caatcaaaat ctatttcaga    20340

taacatccca tcgacggcta caagcttaca gaacacacag cccgaggatg acacttgggc    20400

aattcaagag caggggggtc cagagtttgt ccatcttcat ctgcctctac aaccaatatt    20460

agagaagtcc agagactggg aaaaccgttg tgtatccagt aattacatga ctatcattaa    20520

tattatctag gaaagaaact atcattcatt aaagggctat gcccagttct gtatgcttta    20580

catgcattat ttaataaaaa tcatttaatt ctccccaaaa tactgaaagg tagatatcat    20640

ttttatttta cagctaaaaa agctaaggct cagagaagta aaataatgct cccaagatca    20700

cacagcccat aaacggcagt gagacaactg attctaatgc atgtgttctt tccatagcac    20760

agctactctc gtgagtactg gactgaggga ttaagaaaaa ctatttggca attcctgcct    20820

actgtttcac tcaacatatt ccctatgatc ctggcttccc tgcgtttggt ttttctattt    20880

tctttgctac cttccctaca cacttgacca aatactatga gcttctggct gcatgctctt    20940

tttctctcca tcagggagct ctcgtgtatt ctgacatctt taatgaacac atctaagatg    21000

tccacatgct tgacaagagc caacaaattg aagtggttgt caaaaagcac aaaattaagt    21060

tgtattagta aaaatagggc tgtggtcaag gcaaggaagt ggatggatgc cccgtgcttg    21120

gggtcgatca ggccacatca gagtcaaggt ctgatttgga accccacaaa caaaagggaa    21180

ttcataatca ggtgatgggt ctgaacatag tcacctaaca caagagaact gtagtgtcaa    21240

cctggagaag agaaagcagc cagcgagttc gaaggaacac taaacttttt caaatgttgg    21300

gagggtttca taggaaagag gaaataacct tattaggtgt tgcatcagga aaaatggata    21360

ctagtttcag gttaaaaatt attgaaaata ttacaactat gtataagtga aacaatagga    21420

tctgaaaagt aataaacaat tagcatgtaa gatgttcaag gaaagaagag ttgaccatgg    21480

gctatgaaaa ctgggaagga cttgtactgg gacacactaa gagcctgtga tacccaattc    21540

tctatctcta actgtatatt gctttctgag ctcaggttct atattccctt aacatcaata    21600

tgtctaacat taaagccctt gtctttttca ccctatcttc atttttacat gttaacattc    21660

cagtccattt tagttattaa ggctttttgc ttgggcacca gaagaagggg tttttttctt    21720

tgtaatgttt ttctttggcg taatcctaat ccaagtgatt acatctcatt actggatact    21780

gcaaaagcct cctacatgtt ctttcttacc actgttcctc ctaaatcctt aatttttatt    21840

ttgttaatct cctgtgaact ttcactagct cttcatactc tacaaaataa aaccaaattc    21900

ttcaccctgg cattccatct tctacaagtc tccggcactc tgtttgtctg tgcagaccta    21960

attggatatg atgtctctgc ctcacagacc ttcccccacc ctccataccc ctcaggatca    22020

ctgcctttgc caataaatat caccagatat tgcttagaac atgcagcacc caccctaatt    22080

tcttccatgt tccaatctct caataaatat ctcctatgtt gatttcatat tactcatcaa    22140

ttcaaaggcc tatgtaggga tgttgtatat tccagctcat cctacaattt gggggtgaaa    22200

agaaaaaatg acatttagtc tgtctataat tgttctgttg ctcaagagct cctcatggag    22260

gggcaaggga atgtgcagaa attaaattca atctgtttaa acttaaggtt atctaatagc    22320

taaaatagtt atttaaataa atcagtctct tttagttaaa aatgctcaga tcctcactcc    22380

ccctccttct ccctctaata tggcatccag gtgtggctta caccgtccac tacataccat    22440

gcaccaaatg gacaaacatg gcttacacca tagtgaagag gaagacttgg aatcttcaga    22500

catgcatggg ataatgttgc ctaaccactt gaatgcttct tgccctgctt cattctaaaa    22560

tgaagttgtc ggctaccata gcttaggatt cacttagtat agtcttgact agggccatag    22620

tgactcagcc tctcttagct cccatgggca atttagactt ctccctgttt gagtatgact    22680

cacatttgtc cctagtatgt actccatcta cactgctcct tttagagcca cttcacttcc    22740

tctatggcaa cactctctgg aaacctccag accagatgct cagacacttc tatatttagt    22800

ctatgctaca gagaaatagc gagtggcata cggtatagtc aatctcagct ctttcttcct    22860

gaccacattg ttctgccaag cttactgaaa gttggctgca cccaagagtg ataaaaccca    22920

ggatatgaag cagcatattt acagatcctg ccccttcccc caccaaaata aaagaatgaa    22980

ttcaaatata gatataaata ctttactctc ctcctctgct ttctcttttt catcccatta    23040

ttctcccagg gacttttaaa tgtcagaaga ttcttctatt tgcagatttt ctgtttaaaa    23100

agaagcaaga aagaaaggaa agaaaaagaa aatactcctt taggcagatg aatacctctg    23160

atgatcagaa tgaagggaga aaagagaaag agagagagag agagagagaa ctaattttaa    23220

tatatgaaat ccattttact tgcaatgact cactattccc actatgtagg tttattcata    23280

ttatgtctca attgtgtcct gtttccaaac aattgaatat gccgcttatt cttaaaatat    23340

tctcacaatt tcccttctgc atatttgaat agtacccatt tttcaagcct agttcattct    23400

tctttctcca tgaaacctga tttgaccatt ctagaatgac ctctaccagt aaacctctat    23460

tgagttaata gatccttttt attaaatatc tggtggatgg tttttatatt gcctaagaat    23520

tattatattt taaaaatttt acataaaata atcacttcat attgaaaatt gtattttagc    23580

aggaagaaaa aaacaaagac aatattggtt ttcaccattt gggcaagaga ataaatcaag    23640

agctatcatc taaagaaaat attgtccagg aaagaaagaa agatttgtcc ctttctgaag    23700

ccagtgagaa taagggaagt agtaaatctc aaaattattt cacaaataga cagagactga    23760

ataaagaata tagtatcagt aacaaagaga atactcacaa tggcctgagg atgtcaattt    23820

atcctaagtc aactgggaat aaagggtttg aggatggaga tgatgctatc agcaaactac    23880

atgaccaaga agaatatggc gcagctctca tcagaaataa catgcaacat ataatggggc    23940

cagtgactgc gattaaactc ctgggggaag aaaacaaaga gaacacacct aggaatgttc    24000

taaacataat cccagcaagt atgaattatg ctaaagcaca ctcgaaggat aaaaagaagc    24060

ctcaaagaga ttcccaagcc cagaaaagtc cagtaaaaag caaaagcacc catcgtattc    24120

aacacaacat tgactaccta aaacatctct caaaagtcaa aaaaatcccc agtgattttg    24180

aaggcagcgg ttatacagat cttcaagaga gaggggacaa tgatatatct cctttcagtg    24240

gggacggcca accttttaag gacattcctg gtaaaggaga agctactggt cctgacctag    24300

aaggcaaaga tattcaaaca gggtttgcag gcccaagtga agctgagagt actcatcttg    24360

acacaaaaaa gccaggttat aatgagatcc cagagagaga agaaaatggt ggaaatacca    24420

ttggaactag ggatgaaact gcgaaagagg cagatgctgt tgatgtcagc cttgtagagg    24480

gcagcaacga tatcatgggt agtaccaatt ttaaggagct ccctggaaga gaaggaaaca    24540

gagtggatgc tggcagccaa aatgctcacc aagggaaggt tgagtttcat taccctcctg    24600

caccctcaaa agagaaaaga aaagaaggca gtagtgatgc agctgaaagt accaactata    24660

atgaaattcc taaaaatggc aaaggcagta ccagaaaggg tgtagatcat tctaatagga    24720

accaagcaac cttaaatgaa aaacaaaggt ttcctagtaa gggcaaaagt cagggcctgc    24780

ccattccttc tcgtggtctt gataatgaaa tcaaaaacga aatggattcc tttaatggcc    24840

ccagtcatga gaatataata acacatggca gaaaatatca ttatgtaccc cacagacaaa    24900

ataattctac acggaataag ggtatgccac aagggaaagg ctcctggggt agacaacccc    24960

attccaacag gaggtttagt tcccgtagaa gggatgacag tagtgagtca tctgacagtg    25020

gcagttcaag tgagagcgat ggtgactagt ccaccaggag ttcccagcgg ggtgacagtc    25080

tgaagacctc gtcacctgtg agttgatgta gaggagagcc acctgacagc tgaccaggtg    25140

aagagaggat agagtgaaga actgagtgag ccaagaatcc tggtctcctt gggggaattt    25200

ttgctatctt aatagtcaca gtataaaatt ctattaaagg ctataatgtt tttaagcaaa    25260

aaaaaatcat tacagatcta tgaaataggt aacatttgag taggtgtcat ttaaaaatag    25320

ttggtgaatg tcacaaatgc cttctatgtt gtttgctctg tagacatgaa aataaacaat    25380

atctctcgat gataatttgt attaagtaat ctataagaaa                          25420


<210>  2
<211>  2035
<212>  DNA
<213>  homo sapien

<400>  2
uuuacauaaa cauaugcagu gcuccccugg ccugccggca gcuauccaca ccagaaagag       60

gaaaagguag acugagauuc ucaaagaugc gaguuuucug ugugggacua cuccuuuuca      120

gugugaccug ggcagcacca acauuucaac cacagacuga gaaaacuaag caaagcugug      180

uggaagagca gaggcaggaa gaaaaaaaca aagacaauau ugguuuucac cauuugggca      240

agagaauaaa ucaagagcua ucaucuaaag aaaauauugu ccaggaaaga aagaaagauu      300

ugucccuuuc ugaagccagu gagaauaagg gaaguaguaa aucucaaaau uauuucacaa      360

auagacagag acugaauaaa gaauauagua ucaguaacaa agagaauacu cacaauggcc      420

ugaggauguc aauuuauccu aagucaacug ggaauaaagg guuugaggau ggagaugaug      480

cuaucagcaa acuacaugac caagaagaau auggcgcagc ucucaucaga aauaacaugc      540

aacauauaau ggggccagug acugcgauua aacuccuggg ggaagaaaac aaagagaaca      600

caccuaggaa uguucuaaac auaaucccag caaguaugaa uuaugcuaaa gcacacucga      660

aggauaaaaa gaagccucaa agagauuccc aagcccagaa aaguccagua aaaagcaaaa      720

gcacccaucg uauucaacac aacauugacu accuaaaaca ucucucaaaa gucaaaaaaa      780

uccccaguga uuuugaaggc agcgguuaua cagaucuuca agagagaggg gacaaugaua      840

uaucuccuuu caguggggac ggccaaccuu uuaaggacau uccugguaaa ggagaagcua      900

cugguccuga ccuagaaggc aaagauauuc aaacaggguu ugcaggccca agugaagcug      960

agaguacuca ucuugacaca aaaaagccag guuauaauga gaucccagag agagaagaaa     1020

augguggaaa uaccauugga acuagggaug aaacugcgaa agaggcagau gcuguugaug     1080

ucagccuugu agagggcagc aacgauauca uggguaguac caauuuuaag gagcucccug     1140

gaagagaagg aaacagagug gaugcuggca gccaaaaugc ucaccaaggg aagguugagu     1200

uucauuaccc uccugcaccc ucaaaagaga aaagaaaaga aggcaguagu gaugcagcug     1260

aaaguaccaa cuauaaugaa auuccuaaaa auggcaaagg caguaccaga aaggguguag     1320

aucauucuaa uaggaaccaa gcaaccuuaa augaaaaaca aagguuuccu aguaagggca     1380

aaagucaggg ccugcccauu ccuucucgug gucuugauaa ugaaaucaaa aacgaaaugg     1440

auuccuuuaa uggccccagu caugagaaua uaauaacaca uggcagaaaa uaucauuaug     1500

uaccccacag acaaaauaau ucuacacgga auaaggguau gccacaaggg aaaggcuccu     1560

gggguagaca accccauucc aacaggaggu uuaguucccg uagaagggau gacaguagug     1620

agucaucuga caguggcagu ucaagugaga gcgaugguga cuaguccacc aggaguuccc     1680

agcgggguga cagucugaag accucgucac cugugaguug auguagagga gagccaccug     1740

acagcugacc aggugaagag aggauagagu gaagaacuga gugagccaag aauccugguc     1800

uccuuggggg aauuuuugcu aucuuaauag ucacaguaua aaauucuauu aaaggcuaua     1860

auguuuuuaa gcaaaaaaaa aucauuacag aucuaugaaa uagguaacau uugaguaggu     1920

gucauuuaaa aauaguuggu gaaugucaca aaugccuucu auguuguuug cucuguagac     1980

augaaaauaa acaauaucuc ucgaugauaa uuuguauuaa guaaucuaua agaaa          2035


<210>  3
<211>  2035
<212>  DNA
<213>  homo sapien

<400>  3
tttacataaa catatgcagt gctcccctgg cctgccggca gctatccaca ccagaaagag       60

gaaaaggtag actgagattc tcaaagatgc gagttttctg tgtgggacta ctccttttca      120

gtgtgacctg ggcagcacca acatttcaac cacagactga gaaaactaag caaagctgtg      180

tggaagagca gaggcaggaa gaaaaaaaca aagacaatat tggttttcac catttgggca      240

agagaataaa tcaagagcta tcatctaaag aaaatattgt ccaggaaaga aagaaagatt      300

tgtccctttc tgaagccagt gagaataagg gaagtagtaa atctcaaaat tatttcacaa      360

atagacagag actgaataaa gaatatagta tcagtaacaa agagaatact cacaatggcc      420

tgaggatgtc aatttatcct aagtcaactg ggaataaagg gtttgaggat ggagatgatg      480

ctatcagcaa actacatgac caagaagaat atggcgcagc tctcatcaga aataacatgc      540

aacatataat ggggccagtg actgcgatta aactcctggg ggaagaaaac aaagagaaca      600

cacctaggaa tgttctaaac ataatcccag caagtatgaa ttatgctaaa gcacactcga      660

aggataaaaa gaagcctcaa agagattccc aagcccagaa aagtccagta aaaagcaaaa      720

gcacccatcg tattcaacac aacattgact acctaaaaca tctctcaaaa gtcaaaaaaa      780

tccccagtga ttttgaaggc agcggttata cagatcttca agagagaggg gacaatgata      840

tatctccttt cagtggggac ggccaacctt ttaaggacat tcctggtaaa ggagaagcta      900

ctggtcctga cctagaaggc aaagatattc aaacagggtt tgcaggccca agtgaagctg      960

agagtactca tcttgacaca aaaaagccag gttataatga gatcccagag agagaagaaa     1020

atggtggaaa taccattgga actagggatg aaactgcgaa agaggcagat gctgttgatg     1080

tcagccttgt agagggcagc aacgatatca tgggtagtac caattttaag gagctccctg     1140

gaagagaagg aaacagagtg gatgctggca gccaaaatgc tcaccaaggg aaggttgagt     1200

ttcattaccc tcctgcaccc tcaaaagaga aaagaaaaga aggcagtagt gatgcagctg     1260

aaagtaccaa ctataatgaa attcctaaaa atggcaaagg cagtaccaga aagggtgtag     1320

atcattctaa taggaaccaa gcaaccttaa atgaaaaaca aaggtttcct agtaagggca     1380

aaagtcaggg cctgcccatt ccttctcgtg gtcttgataa tgaaatcaaa aacgaaatgg     1440

attcctttaa tggccccagt catgagaata taataacaca tggcagaaaa tatcattatg     1500

taccccacag acaaaataat tctacacgga ataagggtat gccacaaggg aaaggctcct     1560

ggggtagaca accccattcc aacaggaggt ttagttcccg tagaagggat gacagtagtg     1620

agtcatctga cagtggcagt tcaagtgaga gcgatggtga ctagtccacc aggagttccc     1680

agcggggtga cagtctgaag acctcgtcac ctgtgagttg atgtagagga gagccacctg     1740

acagctgacc aggtgaagag aggatagagt gaagaactga gtgagccaag aatcctggtc     1800

tccttggggg aatttttgct atcttaatag tcacagtata aaattctatt aaaggctata     1860

atgtttttaa gcaaaaaaaa atcattacag atctatgaaa taggtaacat ttgagtaggt     1920

gtcatttaaa aatagttggt gaatgtcaca aatgccttct atgttgtttg ctctgtagac     1980

atgaaaataa acaatatctc tcgatgataa tttgtattaa gtaatctata agaaa          2035


<210>  4
<211>  525
<212>  PRT
<213>  homo sapien

<400>  4

Met Arg Val Phe Cys Val Gly Leu Leu Leu Phe Ser Val Thr Trp Ala 
1               5                   10                  15      


Ala Pro Thr Phe Gln Pro Gln Thr Glu Lys Thr Lys Gln Ser Cys Val 
            20                  25                  30          


Glu Glu Gln Arg Gln Glu Glu Lys Asn Lys Asp Asn Ile Gly Phe His 
        35                  40                  45              


His Leu Gly Lys Arg Ile Asn Gln Glu Leu Ser Ser Lys Glu Asn Ile 
    50                  55                  60                  


Val Gln Glu Arg Lys Lys Asp Leu Ser Leu Ser Glu Ala Ser Glu Asn 
65                  70                  75                  80  


Lys Gly Ser Ser Lys Ser Gln Asn Tyr Phe Thr Asn Arg Gln Arg Leu 
                85                  90                  95      


Asn Lys Glu Tyr Ser Ile Ser Asn Lys Glu Asn Thr His Asn Gly Leu 
            100                 105                 110         


Arg Met Ser Ile Tyr Pro Lys Ser Thr Gly Asn Lys Gly Phe Glu Asp 
        115                 120                 125             


Gly Asp Asp Ala Ile Ser Lys Leu His Asp Gln Glu Glu Tyr Gly Ala 
    130                 135                 140                 


Ala Leu Ile Arg Asn Asn Met Gln His Ile Met Gly Pro Val Thr Ala 
145                 150                 155                 160 


Ile Lys Leu Leu Gly Glu Glu Asn Lys Glu Asn Thr Pro Arg Asn Val 
                165                 170                 175     


Leu Asn Ile Ile Pro Ala Ser Met Asn Tyr Ala Lys Ala His Ser Lys 
            180                 185                 190         


Asp Lys Lys Lys Pro Gln Arg Asp Ser Gln Ala Gln Lys Ser Pro Val 
        195                 200                 205             


Lys Ser Lys Ser Thr His Arg Ile Gln His Asn Ile Asp Tyr Leu Lys 
    210                 215                 220                 


His Leu Ser Lys Val Lys Lys Ile Pro Ser Asp Phe Glu Gly Ser Gly 
225                 230                 235                 240 


Tyr Thr Asp Leu Gln Glu Arg Gly Asp Asn Asp Ile Ser Pro Phe Ser 
                245                 250                 255     


Gly Asp Gly Gln Pro Phe Lys Asp Ile Pro Gly Lys Gly Glu Ala Thr 
            260                 265                 270         


Gly Pro Asp Leu Glu Gly Lys Asp Ile Gln Thr Gly Phe Ala Gly Pro 
        275                 280                 285             


Ser Glu Ala Glu Ser Thr His Leu Asp Thr Lys Lys Pro Gly Tyr Asn 
    290                 295                 300                 


Glu Ile Pro Glu Arg Glu Glu Asn Gly Gly Asn Thr Ile Gly Thr Arg 
305                 310                 315                 320 


Asp Glu Thr Ala Lys Glu Ala Asp Ala Val Asp Val Ser Leu Val Glu 
                325                 330                 335     


Gly Ser Asn Asp Ile Met Gly Ser Thr Asn Phe Lys Glu Leu Pro Gly 
            340                 345                 350         


Arg Glu Gly Asn Arg Val Asp Ala Gly Ser Gln Asn Ala His Gln Gly 
        355                 360                 365             


Lys Val Glu Phe His Tyr Pro Pro Ala Pro Ser Lys Glu Lys Arg Lys 
    370                 375                 380                 


Glu Gly Ser Ser Asp Ala Ala Glu Ser Thr Asn Tyr Asn Glu Ile Pro 
385                 390                 395                 400 


Lys Asn Gly Lys Gly Ser Thr Arg Lys Gly Val Asp His Ser Asn Arg 
                405                 410                 415     


Asn Gln Ala Thr Leu Asn Glu Lys Gln Arg Phe Pro Ser Lys Gly Lys 
            420                 425                 430         


Ser Gln Gly Leu Pro Ile Pro Ser Arg Gly Leu Asp Asn Glu Ile Lys 
        435                 440                 445             


Asn Glu Met Asp Ser Phe Asn Gly Pro Ser His Glu Asn Ile Ile Thr 
    450                 455                 460                 


His Gly Arg Lys Tyr His Tyr Val Pro His Arg Gln Asn Asn Ser Thr 
465                 470                 475                 480 


Arg Asn Lys Gly Met Pro Gln Gly Lys Gly Ser Trp Gly Arg Gln Pro 
                485                 490                 495     


His Ser Asn Arg Arg Phe Ser Ser Arg Arg Arg Asp Asp Ser Ser Glu 
            500                 505                 510         


Ser Ser Asp Ser Gly Ser Ser Ser Glu Ser Asp Gly Asp 
        515                 520                 525 


