                         SEQUENCE LISTING

<110>  Zymergen Inc.
 
<120>  ENGINEERED BIOSYNTHETIC PATHWAYS FOR PRODUCTION OF 2-OXOADIPATE 
       BY FERMENTATION

<130>  ZMGNP009WOUS

<150>  62/773,118
<151>  2018-11-29

<160>  121   

<170>  PatentIn version 3.5

<210>  1
<211>  693
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Leu Arg Ser Thr Thr Phe Thr Arg Ser Phe His Ser Ser Arg Ala 
1               5                   10                  15      


Trp Leu Lys Gly Gln Asn Leu Thr Glu Lys Ile Val Gln Ser Tyr Ala 
            20                  25                  30          


Val Asn Leu Pro Glu Gly Lys Val Val His Ser Gly Asp Tyr Val Ser 
        35                  40                  45              


Ile Lys Pro Ala His Cys Met Ser His Asp Asn Ser Trp Pro Val Ala 
    50                  55                  60                  


Leu Lys Phe Met Gly Leu Gly Ala Thr Lys Ile Lys Asn Pro Ser Gln 
65                  70                  75                  80  


Ile Val Thr Thr Leu Asp His Asp Ile Gln Asn Lys Ser Glu Lys Asn 
                85                  90                  95      


Leu Thr Lys Tyr Lys Asn Ile Glu Asn Phe Ala Lys Lys His His Ile 
            100                 105                 110         


Asp His Tyr Pro Ala Gly Arg Gly Ile Gly His Gln Ile Met Ile Glu 
        115                 120                 125             


Glu Gly Tyr Ala Phe Pro Leu Asn Met Thr Val Ala Ser Asp Ser His 
    130                 135                 140                 


Ser Asn Thr Tyr Gly Gly Leu Gly Ser Leu Gly Thr Pro Ile Val Arg 
145                 150                 155                 160 


Thr Asp Ala Ala Ala Ile Trp Ala Thr Gly Gln Thr Trp Trp Gln Ile 
                165                 170                 175     


Pro Pro Val Ala Gln Val Glu Leu Lys Gly Gln Leu Pro Gln Gly Val 
            180                 185                 190         


Ser Gly Lys Asp Ile Ile Val Ala Leu Cys Gly Leu Phe Asn Asn Asp 
        195                 200                 205             


Gln Val Leu Asn His Ala Ile Glu Phe Thr Gly Asp Ser Leu Asn Ala 
    210                 215                 220                 


Leu Pro Ile Asp His Arg Leu Thr Ile Ala Asn Met Thr Thr Glu Trp 
225                 230                 235                 240 


Gly Ala Leu Ser Gly Leu Phe Pro Val Asp Lys Thr Leu Ile Asp Trp 
                245                 250                 255     


Tyr Lys Asn Arg Leu Gln Lys Leu Gly Thr Asn Asn His Pro Arg Ile 
            260                 265                 270         


Asn Pro Lys Thr Ile Arg Ala Leu Glu Glu Lys Ala Lys Ile Pro Lys 
        275                 280                 285             


Ala Asp Lys Asp Ala His Tyr Ala Lys Lys Leu Ile Ile Asp Leu Ala 
    290                 295                 300                 


Thr Leu Thr His Tyr Val Ser Gly Pro Asn Ser Val Lys Val Ser Asn 
305                 310                 315                 320 


Thr Val Gln Asp Leu Ser Gln Gln Asp Ile Lys Ile Asn Lys Ala Tyr 
                325                 330                 335     


Leu Val Ser Cys Thr Asn Ser Arg Leu Ser Asp Leu Gln Ser Ala Ala 
            340                 345                 350         


Asp Val Val Cys Pro Thr Gly Asp Leu Asn Lys Val Asn Lys Val Ala 
        355                 360                 365             


Pro Gly Val Glu Phe Tyr Val Ala Ala Ala Ser Ser Glu Ile Glu Ala 
    370                 375                 380                 


Asp Ala Arg Lys Ser Gly Ala Trp Glu Lys Leu Leu Lys Ala Gly Cys 
385                 390                 395                 400 


Ile Pro Leu Pro Ser Gly Cys Gly Pro Cys Ile Gly Leu Gly Ala Gly 
                405                 410                 415     


Leu Leu Glu Pro Gly Glu Val Gly Ile Ser Ala Thr Asn Arg Asn Phe 
            420                 425                 430         


Lys Gly Arg Met Gly Ser Lys Asp Ala Leu Ala Tyr Leu Ala Ser Pro 
        435                 440                 445             


Ala Val Val Ala Ala Ser Ala Val Leu Gly Lys Ile Ser Ser Pro Ala 
    450                 455                 460                 


Glu Val Leu Ser Thr Ser Glu Ile Pro Phe Ser Gly Val Lys Thr Glu 
465                 470                 475                 480 


Ile Ile Glu Asn Pro Val Val Glu Glu Glu Val Asn Ala Gln Thr Glu 
                485                 490                 495     


Ala Pro Lys Gln Ser Val Glu Ile Leu Glu Gly Phe Pro Arg Glu Phe 
            500                 505                 510         


Ser Gly Glu Leu Val Leu Cys Asp Ala Asp Asn Ile Asn Thr Asp Gly 
        515                 520                 525             


Ile Tyr Pro Gly Lys Tyr Thr Tyr Gln Asp Asp Val Pro Lys Glu Lys 
    530                 535                 540                 


Met Ala Gln Val Cys Met Glu Asn Tyr Asp Ala Glu Phe Arg Thr Lys 
545                 550                 555                 560 


Val His Pro Gly Asp Ile Val Val Ser Gly Phe Asn Phe Gly Thr Gly 
                565                 570                 575     


Ser Ser Arg Glu Gln Ala Ala Thr Ala Leu Leu Ala Lys Gly Ile Asn 
            580                 585                 590         


Leu Val Val Ser Gly Ser Phe Gly Asn Ile Phe Ser Arg Asn Ser Ile 
        595                 600                 605             


Asn Asn Ala Leu Leu Thr Leu Glu Ile Pro Ala Leu Ile Lys Lys Leu 
    610                 615                 620                 


Arg Glu Lys Tyr Gln Gly Ala Pro Lys Glu Leu Thr Arg Arg Thr Gly 
625                 630                 635                 640 


Trp Phe Leu Lys Trp Asp Val Ala Asp Ala Lys Val Val Val Thr Glu 
                645                 650                 655     


Gly Ser Leu Asp Gly Pro Val Ile Leu Glu Gln Lys Val Gly Glu Leu 
            660                 665                 670         


Gly Lys Asn Leu Gln Glu Ile Ile Val Lys Gly Gly Leu Glu Gly Trp 
        675                 680                 685             


Val Lys Ser Gln Leu 
    690             


<210>  2
<211>  2079
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  2
atgcttcgtt ccaccacgtt cactcgatcg ttccactctt cccgtgcttg gcttaaaggt       60

caaaacttga cagaaaaaat tgtccagtcc tatgcagtta atctgcccga aggaaaggtt      120

gtgcattccg gtgattacgt ttcgatcaaa ccagcacatt gcatgtctca cgacaattca      180

tggcccgtgg cgctcaagtt catgggtctg ggtgctacca aaattaagaa ccctagccag      240

attgtgacta ccctggacca tgatatccaa aataagtcgg aaaaaaactt gacaaagtat      300

aaaaacatcg aaaactttgc aaaaaagcac cacatcgatc attatcccgc gggtcgcggt      360

attggccacc agatcatgat cgaggaagga tacgcattcc cacttaacat gactgtggcc      420

tctgattcac attccaacac atacggcgga ttgggctctt tgggtacgcc catcgtccgc      480

acggacgctg ccgccatttg ggctaccgga cagacgtggt ggcagatccc accagttgcc      540

caagttgagc tcaagggaca gctcccccag ggagtgagcg gtaaagatat catcgtcgcc      600

ctctgcggac ttttcaataa tgatcaagtt ctcaatcacg ccatcgaatt caccggcgat      660

tccctcaacg ctctcccaat tgaccaccgt ctcaccatcg caaacatgac tactgagtgg      720

ggcgcattga gcggtctttt cccagtcgac aagactctga tcgattggta taaaaaccgt      780

cttcagaagc tgggaactaa caaccaccct cgaattaacc ctaagaccat ccgcgccctc      840

gaagaaaagg cgaaaattcc aaaagcagat aaagatgccc actacgcaaa aaaacttatc      900

atcgatcttg ctactctgac ccattacgtg tcaggcccta actccgtcaa agttagcaat      960

acggtacagg atctctctca gcaagacatt aaaatcaaca aagcgtattt ggtctcctgt     1020

actaactcgc gcttgtcaga tctgcagtcc gccgcagatg tcgtgtgccc aaccggagac     1080

cttaacaagg ttaacaaggt ggcaccaggc gtcgaatttt atgtggccgc tgcgagcagc     1140

gagattgagg ctgacgctcg aaagagcgga gcctgggaga agctgcttaa agcaggttgc     1200

atccccctgc cctccggctg cggtccgtgt atcggcctgg gtgcgggctt gctcgaacca     1260

ggcgaagtag gtatttccgc tacaaaccgc aacttcaaag gccgcatggg tagcaaagac     1320

gcactcgcgt acctcgcttc cccagctgtc gttgccgcgt ccgctgtgct cggtaagatt     1380

tcatcacctg cggaagtcct gtcaacgagc gagatcccct tttctggcgt caagaccgag     1440

attatcgaaa accccgtggt ggaggaagaa gtaaacgcac agactgaggc accgaagcag     1500

tcggttgaaa ttttggaagg cttcccccgt gaattctctg gagaacttgt cctttgcgat     1560

gcggacaata ttaacaccga cggcatctat ccaggaaagt atacttatca agatgatgtc     1620

ccgaaggaaa agatggccca agtttgcatg gaaaattacg atgctgaatt tcgcacgaag     1680

gtccatcctg gcgacattgt cgtttccggc ttcaacttcg gaactggtag ctcccgtgag     1740

caagcagcga cggccctcct ggctaaggga atcaacttgg ttgtgtcggg ctctttcggc     1800

aacatcttct ctcgcaacag catcaacaac gcgctcctta ccctcgagat tcctgctctg     1860

attaaaaaat tgcgcgagaa ataccagggc gcaccaaagg aactgacgcg ccgcaccgga     1920

tggtttctga agtgggatgt ggcagacgct aaagtcgttg tcacagaggg ctctctggac     1980

ggcccagtca ttttggagca gaaagtaggc gagctgggca agaatctgca ggaaatcatc     2040

gtgaagggtg gcttggaagg atgggtaaag agccaattg                            2079


<210>  3
<211>  371
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  4
<211>  1113
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  4
atgtttcgat ccgtggcgac ccgcctgtct gcatgccgtg gcttggcaag caacgctgct       60

cgcaaatctt tgacgatcgg tctgatcccg ggtgacggaa ttggcaagga agtaattccc      120

gctggtaagc aggtcctcga aaatttgaac tccaaacacg gtctttcatt taatttcatc      180

gatttgtacg ccggctttca gacatttcaa gagaccggca aagctcttcc agatgaaact      240

gtgaaggtgc tcaaggaaca gtgtcaagga gctttgtttg gagccgtaca gtccccaacc      300

acaaaggtgg agggctactc atcccctatc gtcgctctcc gccgcgaaat gggtctgttc      360

gccaacgtgc gcccggtgaa aagcgtggag ggtgagaaag gaaagccaat cgatatggtt      420

attgtgcgtg aaaataccga ggatttgtac attaagatcg aaaagacgta catcgacaaa      480

gccaccggta cccgagtggc cgatgcaaca aaacgcatct cagagatcgc aactcgccgt      540

attgcaacca tcgctttgga cattgcgctc aaacgcctcc aaacccgcgg tcaggcaact      600

ctgaccgtta ctcacaagag caatgtgctg tcccagtccg acggtctgtt ccgcgagatc      660

tgcaaggagg tgtacgagtc caataaggat aaatacggcc aaattaagta caatgaacag      720

attgtggata gcatggttta tcgccttttc cgcgaacccc aatgtttcga tgtcatcgtg      780

gcccctaacc tgtacggaga catcctttca gacggtgctg cggctctggt gggctcgctt      840

ggcgtcgttc catctgccaa cgtcggccca gaaatcgtca ttggcgaacc atgccacggt      900

tccgcaccag acattgctgg caaaggcatt gctaatccta ttgccaccat tcgttccact      960

gcgctgatgt tggagttcct gggacacaac gaagcggctc aggatattta caaagcagtc     1020

gacgcaaact tgcgtgaagg atcgattaag accccggatt tgggcggaaa agctagcaca     1080

caacaagttg ttgatgacgt gctttcccgc ctt                                  1113


<210>  5
<211>  491
<212>  PRT
<213>  Cryptococcus neoformans

<400>  5

Met Cys Pro Pro Ala Asp Glu Pro Ile Asn Ala Gly Ala Asp Gln Asp 
1               5                   10                  15      


Met Val Ala Ile Glu Thr Asn Thr Pro His Ile Ser Thr Ser Ser Ala 
            20                  25                  30          


Asn Gln Val Asn Gly Thr Thr Gly Thr Ala Glu Ala Gln Pro Pro Ala 
        35                  40                  45              


Val Lys Thr His Lys Gly Leu Tyr Gly Arg Ala Ser Asp Phe Leu Ser 
    50                  55                  60                  


Asn Thr Ser Asn Trp Lys Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu 
65                  70                  75                  80  


Gln Phe Ala Asn Ala Phe Phe Thr Leu Glu Thr Lys Ile Lys Ile Ala 
                85                  90                  95      


Lys Met Leu Asp Glu Phe Gly Val Glu Tyr Ile Glu Leu Thr Ser Pro 
            100                 105                 110         


Ala Ala Ser Pro Glu Ser Arg Ala His Cys Glu Ala Ile Cys Asn Leu 
        115                 120                 125             


Gly Leu Lys Arg Thr Lys Ile Leu Thr His Ile Arg Cys His Met Asp 
    130                 135                 140                 


Asp Ala Arg Leu Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val 
145                 150                 155                 160 


Ile Gly Thr Ser Ser Phe Leu Arg Glu His Ser His Gly Lys Asp Met 
                165                 170                 175     


Thr Trp Ile Thr Lys Thr Ala Ile Glu Val Ile Glu Phe Val Lys Ser 
            180                 185                 190         


Lys Gly Ile Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Glu 
        195                 200                 205             


Leu Val Asp Leu Leu Ser Ile Tyr Arg Thr Val Asp Lys Ile Gly Val 
    210                 215                 220                 


Asn Arg Val Gly Val Ala Asp Thr Val Gly Cys Ala Asp Ala Arg Gln 
225                 230                 235                 240 


Val Tyr Glu Leu Val Arg Thr Leu Arg Gly Val Val Ser Cys Asp Ile 
                245                 250                 255     


Glu Thr His Phe His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala Tyr 
            260                 265                 270         


Ala Ala Leu Glu Ala Gly Ala Thr His Val Asp Thr Ser Ile Leu Gly 
        275                 280                 285             


Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Ile Ala Arg 
    290                 295                 300                 


Met Met Val Ala Asp Pro Glu Tyr Val Lys Ser Lys Tyr Asn Leu Thr 
305                 310                 315                 320 


Met Leu Arg Glu Leu Glu Asn Phe Val Ala Glu Ala Val Glu Val Gln 
                325                 330                 335     


Val Pro Phe Asn Asn Tyr Ile Thr Gly Phe Cys Ala Phe Thr His Lys 
            340                 345                 350         


Ala Gly Ile His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu 
        355                 360                 365             


Ile Leu Asn Pro Ala Asp Phe Gly Met Thr Arg Tyr Val Ser Ile Gly 
    370                 375                 380                 


His Arg Leu Thr Gly Trp Asn Ala Val Lys Ser Arg Val Glu Gln Leu 
385                 390                 395                 400 


Asn Leu Lys Leu Asn Asp Glu Gln Val Lys Asp Ala Thr Ala Lys Ile 
                405                 410                 415     


Lys Glu Leu Ala Asp Val Arg Thr Gln Ser Met Glu Asp Val Asp Met 
            420                 425                 430         


Ile Leu Arg Ile Tyr His Thr Gly Ile Gln Ser Gly Asp Leu Lys Val 
        435                 440                 445             


Gly Gln Ser Ala Val Leu Asp Arg Leu Leu Glu Lys His Met Pro Ser 
    450                 455                 460                 


Arg Asp Asn Ser Pro Ser Gly Arg Ser Ser Asn Ala Asp Gly Thr Pro 
465                 470                 475                 480 


Ala Lys Arg Gln Arg Val Gly Glu Pro Ser Ala 
                485                 490     


<210>  6
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  6
atgtgcccac cagcagacga gccaattaac gcaggagcgg atcaggatat ggtggcgatc       60

gaaacaaata ccccacacat ctctacctcg agcgcaaacc aggtgaacgg caccactgga      120

accgccgagg cccagccacc agccgtgaaa acgcataagg gcctgtacgg ccgcgcgtcc      180

gacttcttgt ctaacacatc gaactggaag attatcgagt ctaccttgcg agagggtgaa      240

cagttcgcca acgctttctt cacattggag acgaagatca agatcgcaaa gatgttggat      300

gagttcggcg ttgagtatat tgaactgacg agcccggcag ccagccctga gtcccgtgcc      360

cactgcgaag ctatttgcaa cctgggattg aagcgcacca aaatcttgac ccacatccgc      420

tgtcatatgg atgacgcacg tcttgctgtt gagactggtg ttgacggagt ggatgtggtg      480

atcggcacct catccttctt gcgcgagcac tctcatggta aggacatgac gtggattacc      540

aagaccgcaa tcgaggtcat cgagttcgtg aagtccaagg gtattgagat tcgcttcagc      600

agcgaagatt ccttccgttc cgagttggta gatctgcttt ccatttaccg caccgtggat      660

aaaatcggtg ttaatcgtgt gggtgtggca gataccgtgg gctgcgccga cgctcgtcag      720

gtgtacgagc tcgtacgcac attgcgcggc gtcgtgagct gcgatattga aacccatttc      780

cacaacgata ccggttgtgc cattgctaat gcgtacgcag cactggaagc gggagccacg      840

cacgtggata cctccatttt gggcattggc gaacgcaacg gtattactcc tcttggcggc      900

ttgatcgcgc gcatgatggt cgccgatcca gaatacgtta aatcaaagta taacctcacc      960

atgctgcgcg aattggaaaa ctttgttgca gaggcagtcg aagttcaagt gcctttcaac     1020

aattacatca ccggcttctg cgcattcacg cacaaagcag gtattcatgc taaagctatt     1080

ttggccaacc cgtctaccta cgagattctg aacccagctg acttcggcat gacccgttac     1140

gtatcaatcg gtcatcgact cacaggttgg aatgcggtca agtctcgcgt ggagcaattg     1200

aacctgaagc tcaacgacga acaagtgaaa gatgcaacag ccaaaattaa agagctggca     1260

gacgtccgta cccagtccat ggaagacgtg gacatgattc ttcgcatcta ccataccggt     1320

atccaatcgg gcgatctcaa agtgggacag agcgcagttc ttgatcgcct tctggaaaaa     1380

cacatgcctt cccgagataa cagcccttcg ggacgctcat ccaacgccga tggaactccc     1440

gcaaagcgcc agcgtgttgg tgagccatct gcg                                  1473


<210>  7
<211>  392
<212>  PRT
<213>  Unknown

<220>
<223>  Arc I group archaeon ADurb1113_Bin01801

<400>  7

Met Lys Ser Phe Val Ser Pro Tyr Asn Phe Val Glu Asn Val Asn Leu 
1               5                   10                  15      


Lys Val Asp Pro Lys Asp Ile Ile Val Tyr Asp Thr Thr Leu Arg Asp 
            20                  25                  30          


Gly Glu Gln Thr Pro Gly Ile Cys Phe Thr Pro Asp Glu Lys Ile Asp 
        35                  40                  45              


Ile Ala Ile Lys Leu Asp Glu Leu Gly Val Asn Gln Ile Glu Ala Gly 
    50                  55                  60                  


Phe Pro Val Val Ser Asp Gly Glu Arg Arg Ala Ile Arg Asn Ile Met 
65                  70                  75                  80  


Lys Gln Ser Leu Asn Ser Glu Ile Leu Ala Leu Thr Arg Thr Leu Lys 
                85                  90                  95      


Ser Asp Ile Asp Val Ala Leu Ser Cys Asp Val Asp Gly Ile Ile Thr 
            100                 105                 110         


Phe Ile Gly Ala Ser Asp Leu His Leu Lys Tyr Lys Leu Lys Met Thr 
        115                 120                 125             


Arg Glu Glu Ala Leu Ser Lys Ala Val Glu Ala Val Glu Tyr Gly Lys 
    130                 135                 140                 


Ser His Gly Ile Phe Val Ala Phe Thr Ala Glu Asp Ser Thr Arg Thr 
145                 150                 155                 160 


Asp Leu Gly Tyr Leu Leu Glu Leu Tyr Lys Ser Thr Thr Glu Ala Gly 
                165                 170                 175     


Ala Asp Arg Ile His Ile Ala Asp Thr Thr Gly Ser Ile Arg Pro Met 
            180                 185                 190         


Gly Met Arg Tyr Leu Val Ser Gln Ile Lys Ala Ser Ile Asp Asn Thr 
        195                 200                 205             


Ile Gly Val His Cys His Asp Asp Phe Gly Leu Ala Val Ala Asn Ser 
    210                 215                 220                 


Leu Ala Ala Phe Glu Ala Gly Ala Arg Ala Ile Ser Thr Ser Met Asn 
225                 230                 235                 240 


Gly Leu Gly Glu Arg Ala Gly Asn Ala Ser Leu Glu Glu Ile Ile Leu 
                245                 250                 255     


Gly Leu Arg Leu Leu Tyr Gly Ile Glu Met Pro Phe Lys Tyr Glu Val 
            260                 265                 270         


Ile Tyr Glu Leu Ser Arg Leu Val Glu Lys Tyr Thr Thr Met Pro Val 
        275                 280                 285             


Pro Lys Asn Lys Ala Val Ile Gly Asp Asn Val Phe Ala His Glu Ser 
    290                 295                 300                 


Gly Ile His Val Leu Ala Val Arg Ala Glu Pro Leu Thr Tyr Glu Pro 
305                 310                 315                 320 


Tyr Ser Pro Glu Phe Val Gly Gln Lys Arg Arg Ile Ile Leu Gly Lys 
                325                 330                 335     


His Cys Gly Met Ser Cys Ile Asp Ala Lys Leu Glu Glu Leu Arg Leu 
            340                 345                 350         


Ser Val Pro Gln Ser Glu Lys Glu Thr Leu Ile Leu Lys Ile Lys Glu 
        355                 360                 365             


Met Ala Glu Arg Gly Ala Lys Val Gly Asp Lys Glu Phe Lys Asn Met 
    370                 375                 380                 


Val Gln Glu Ile Leu Ser Lys Gly 
385                 390         


<210>  8
<211>  1176
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  8
atgaagtcct tcgtctcacc gtataacttt gttgaaaacg tgaacctgaa ggtggaccca       60

aaggatatca ttgtatatga cactactctt cgtgatggcg aacagacccc tggcatctgc      120

tttacaccag atgagaaaat cgacatcgcc attaaattgg atgagctggg tgttaatcag      180

atcgaggccg gttttccagt tgtctcggac ggcgagcgac gtgctatccg caacatcatg      240

aaacaatccc tgaactccga aatcctggcg cttacgcgca cattgaagtc tgatattgat      300

gttgctttgt catgcgatgt agatggcatt atcaccttta tcggagcgtc agacctccat      360

ctgaaataca agttgaaaat gacccgagaa gaagccctgt ccaaggctgt cgaggcagta      420

gaatacggca agtcccacgg aatcttcgtt gcgtttaccg ctgaggactc tactcgcacc      480

gatttgggct atctccttga actttacaaa tccaccaccg aggctggcgc cgatcgcatt      540

cacatcgcgg ataccacagg cagcatccgc cccatgggaa tgcgctacct ggtgtcacag      600

atcaaagcct caatcgataa cacgattggc gttcactgcc atgatgattt cggacttgcg      660

gtggcgaact ccctggccgc ttttgaggcc ggagcgcgcg ccatctccac cagcatgaac      720

ggtttgggcg aacgtgccgg caacgccagc cttgaggaga tcattttggg cttgcgactg      780

ctgtacggca tcgagatgcc attcaaatac gaggtcattt acgagctttc ccgtctcgtg      840

gaaaagtaca ctactatgcc agtcccgaag aacaaagctg tcatcggtga taacgttttc      900

gcccatgaat ctggcattca cgtacttgct gtgcgagcgg aacccctcac ctatgaacca      960

tattcgccag agtttgttgg tcaaaaacgc cgcatcattc tcggcaagca ctgcggcatg     1020

tcatgcattg acgccaagtt ggaagaactt cgactgtccg tcccgcagtc cgagaaggag     1080

accttgattc tcaagattaa agagatggcc gaacgtggtg caaaggtggg cgataaggag     1140

tttaagaaca tggtgcagga aatcttgtcg aaggga                               1176


<210>  9
<211>  371
<212>  PRT
<213>  Saccharomyces arboricola

<400>  9

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Thr Asn Ala Thr Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Arg Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Asn Phe Asp Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Ile Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Thr Lys Asp Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Gln Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Asp Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Thr Ile Thr Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Lys Leu 
    370     


<210>  10
<211>  1113
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  10
atgttccgtt ccgttgccac ccgtctgtcc gcttgccgtg gactcgcaac caacgccacc       60

cgtaaatctc tcacgattgg tctgattccg ggagatggaa tcggcaagga agtcatcccc      120

gccggacgtc aagtgcttga gaacttgaac tctaagcacg gccttaactt tgacttcatc      180

gatctgtacg ccggatttca aacctttcag gaaaccggta aagctctgcc agacgagacc      240

atcaaggttt tgaaggaaca gtgccaggga gcgctgtttg gcgccgttca gtctcctacc      300

accaaagttg agggctattc gtctcctatc gtggcccttc gccgtgagat gggtttgttc      360

gcaaatgttc gtcctgtcaa atctgtagaa ggcaccaagg ataaacccat tgacatggtt      420

atcgtgcgag aaaacactga agatctttat atcaagattg agaagacata catcgacaag      480

gcaaccggca cgcgcgttgc cgatgcgaca aaacgcattt cggaaatcgc cacccgacgc      540

attgccacca tcgccctcga tatcgcactt caacgcctgc aaacacgcgg ccaagctacc      600

ctcaccgtga cccacaagtc caacgtcttg tcacagtcag atggactgtt ccgcgaaatt      660

tgtaaagaag tttatgaatc taacaaagat aaatatggtc aaatcaaata caacgaacag      720

attgtcgata gcatggtcta ccgcctcttc cgcgaacctc agtgtttcga tgttatcgtc      780

gccccgaacc tgtacggaga catcttgtcc gacggtgcag ccgcattggt gggctccctg      840

ggtgtggttc ctagcgcaaa cgtgggcccg gaaattgtaa tcggcgagcc gtgccatggt      900

tctgctcccg atattgcggg taagggcatt gctaacccaa ttgctaccat ccgctccacc      960

gcactcatgc tcgaattcct gggtcacaac gatgcagccc aggatatcta caaggcagtg     1020

gatgcaaatc tccgtgaggg caccatcacc accccagacc tgggtggcaa ggcaagcacc     1080

cagcaagtcg tggatgatgt cttgagcaag ctt                                  1113


<210>  11
<211>  357
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  11

Met Ala Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro 
1               5                   10                  15      


Gly Asp Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu 
            20                  25                  30          


Glu Asn Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu 
        35                  40                  45              


Tyr Ala Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp 
    50                  55                  60                  


Glu Thr Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly 
65                  70                  75                  80  


Ala Val Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile 
                85                  90                  95      


Val Ala Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val 
            100                 105                 110         


Lys Ser Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val 
        115                 120                 125             


Arg Glu Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile 
    130                 135                 140                 


Asp Lys Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser 
145                 150                 155                 160 


Glu Ile Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu 
                165                 170                 175     


Lys Arg Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys 
            180                 185                 190         


Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys 
        195                 200                 205             


Glu Val Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn 
    210                 215                 220                 


Glu Gln Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln 
225                 230                 235                 240 


Cys Phe Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser 
                245                 250                 255     


Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala 
            260                 265                 270         


Asn Val Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala 
        275                 280                 285             


Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg 
    290                 295                 300                 


Ser Thr Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln 
305                 310                 315                 320 


Asp Ile Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys 
                325                 330                 335     


Thr Pro Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp 
            340                 345                 350         


Val Leu Ser Arg Leu 
        355         


<210>  12
<211>  1071
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  12
atggcctcga acgctgcgcg taagtccctg accattggac tcattcctgg tgacggaatc       60

ggtaaggaag tgattccagc aggcaagcag gtcttggaaa atctgaactc gaagcacggt      120

ctgtccttta actttattga cctttacgcg ggattccaga cctttcagga aaccggtaag      180

gccttgccag atgagaccgt taaagtcctg aaagaacaat gccagggcgc actttttggt      240

gcggtgcaat caccgaccac gaaggtggaa ggttactcaa gccctatcgt tgcgcttcgt      300

cgcgagatgg gactgttcgc aaacgttcgc cctgtgaagt ccgttgaggg agaaaaagga      360

aagcccatcg acatggtgat tgtccgagaa aacacagaag atctctacat caagatcgag      420

aagacctaca tcgataaggc aactggtaca cgagtagcag atgcaactaa gcgtatctct      480

gaaattgcga ctcgccgtat cgcaaccatc gcgcttgaca tcgctctgaa gcgcttgcag      540

acccgtggcc aggccaccct gaccgttaca cacaagtcta atgtgctcag ccagtccgat      600

ggtcttttcc gagagatctg taaggaggtg tatgaatcca acaaagacaa atacggccaa      660

atcaagtata atgagcagat cgtggactca atggtttatc gcctgtttcg cgaacctcaa      720

tgtttcgatg tgatcgtggc acctaacctg tatggagaca ttcttagcga cggcgctgcc      780

gccctggtgg gttccctggg cgtggtgcca tctgctaacg tgggccccga gatcgtcatt      840

ggcgaacctt gccacggatc agcaccagat atcgcaggta agggtatcgc aaaccccatc      900

gctacgatcc gatcaaccgc attgatgctc gaatttcttg gtcacaatga ggcagctcag      960

gatatctaca aggctgtgga tgcaaacctt cgtgaaggaa gcatcaaaac cccagacttg     1020

ggtggaaagg catcgacaca acaggtcgtg gacgatgtct tgtcccgcct g              1071


<210>  13
<211>  386
<212>  PRT
<213>  Methanococcus maripaludis

<400>  13

Met Asp Trp Lys Ala Val Ser Pro Tyr Asn Pro Lys Leu Asn Leu Lys 
1               5                   10                  15      


Asp Cys Tyr Leu Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln Thr Pro 
            20                  25                  30          


Gly Val Cys Phe Thr His Asp Gln Lys Leu Glu Ile Ala Lys Lys Leu 
        35                  40                  45              


Asp Glu Leu Lys Ile Lys Gln Ile Glu Ala Gly Phe Pro Ile Val Ser 
    50                  55                  60                  


Glu Asn Glu Arg Lys Ala Ile Lys Ser Ile Thr Gly Glu Gly Leu Asn 
65                  70                  75                  80  


Ala Gln Ile Leu Ala Leu Ser Arg Val Leu Lys Glu Asp Ile Asp Lys 
                85                  90                  95      


Ala Ile Glu Cys Asp Val Asp Gly Ile Ile Thr Phe Ile Ala Ala Ser 
            100                 105                 110         


Pro Met His Leu Lys Tyr Lys Leu His Lys Ser Leu Asp Glu Val Glu 
        115                 120                 125             


Glu Met Gly Met Lys Ala Val Glu Tyr Ala Lys Asp His Gly Leu Phe 
    130                 135                 140                 


Val Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Pro Val Glu Asp Leu 
145                 150                 155                 160 


Ile Arg Ile His Lys Asn Ala Glu Glu His Gly Ala Asn Arg Val His 
                165                 170                 175     


Ile Ala Asp Thr Leu Gly Cys Ala Thr Pro Gln Ala Met Tyr His Ile 
            180                 185                 190         


Cys Ser Glu Leu Ser Ser Asn Leu Lys Lys Ala His Ile Gly Val His 
        195                 200                 205             


Cys His Asn Asp Phe Gly Phe Ala Val Ile Asn Ser Ile Tyr Gly Leu 
    210                 215                 220                 


Ile Gly Gly Ala Lys Ala Val Ser Thr Thr Val Asn Gly Ile Gly Glu 
225                 230                 235                 240 


Arg Ala Gly Asn Ala Ala Ile Glu Glu Ile Val Met Ala Leu Lys Val 
                245                 250                 255     


Leu Tyr Asp His Asp Met Gly Leu Asn Thr Glu Ile Leu Thr Glu Ile 
            260                 265                 270         


Ser Lys Leu Val Glu Asn Tyr Ser Lys Ile Arg Ile Pro Glu Asn Lys 
        275                 280                 285             


Pro Leu Val Gly Glu Met Ala Phe Tyr His Glu Ser Gly Ile His Val 
    290                 295                 300                 


Asp Ala Val Leu Glu Asn Pro Leu Thr Tyr Glu Pro Phe Leu Pro Glu 
305                 310                 315                 320 


Lys Ile Gly Gln Lys Arg Lys Ile Ile Leu Gly Lys His Ser Gly Cys 
                325                 330                 335     


Arg Ala Val Ala His Arg Leu Gln Glu Leu Gly Leu Glu Ala Ser Arg 
            340                 345                 350         


Glu Glu Leu Trp Glu Ile Val Lys Lys Thr Lys Glu Thr Arg Glu Glu 
        355                 360                 365             


Gly Thr Glu Ile Ser Asp Glu Val Phe Lys Asn Ile Val Asp Lys Ile 
    370                 375                 380                 


Ile Lys 
385     


<210>  14
<211>  1158
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  14
atggattgga aagcagtgtc tccatacaac cctaagctga acttgaagga ctgttacctt       60

tacgatacaa ccctccgtga tggcgaacag actcctggag tctgtttcac acacgatcag      120

aaacttgaga ttgcaaagaa actggacgaa ctgaaaatta agcagatcga ggcgggcttc      180

cctattgtct cggaaaatga acgcaaagct attaaatcaa tcaccggcga gggtttgaat      240

gctcagatct tggcattgtc gcgtgtcctg aaggaagata ttgataaggc tatcgaatgt      300

gacgtcgacg gcatcattac gttcatcgcc gcatcaccaa tgcaccttaa atacaaactg      360

cataagtccc tggatgaagt cgaggaaatg ggtatgaagg ctgtggagta cgctaaggat      420

catggcctct ttgtcgcctt tagcgccgaa gacgcgactc gtaccccagt ggaggatctc      480

atccgaatcc acaagaatgc cgaagaacat ggagccaacc gcgtccacat cgcggacacc      540

ttgggttgcg ctacgccgca ggcgatgtat catatttgtt ccgagttgtc atcgaacctt      600

aaaaaggctc acatcggcgt tcactgccac aatgactttg gcttcgctgt catcaactca      660

atctacggct tgatcggcgg cgccaaggca gtttcaacta ctgtcaacgg tatcggtgaa      720

cgcgctggca atgccgcaat tgaagaaatc gtcatggccc tcaaggtgct ctacgatcac      780

gatatgggcc tcaacaccga gatcctgacc gagatcagca aactggtgga gaactactct      840

aagatccgca ttccagagaa taagccactt gtcggcgaaa tggcctttta ccacgaatcc      900

ggcattcatg tcgatgctgt tcttgaaaac ccgctcacat acgagccctt cttgcctgaa      960

aaaatcggtc aaaagcgtaa gatcatcctg ggcaagcact ccggctgtcg cgctgtcgcg     1020

catcgcctcc aggaattggg cttggaagcg tcccgcgaag aactctggga aatcgtgaag     1080

aaaaccaagg aaacacgcga agagggcacg gaaatctcgg atgaggtgtt taagaacatt     1140

gttgacaaaa tcatcaaa                                                   1158


<210>  15
<211>  475
<212>  PRT
<213>  Arthroderma gypseum

<400>  15

Met Ala Thr Asp Thr Gly Ser Arg Pro Cys Cys Ser Ser His Thr Ser 
1               5                   10                  15      


Asp Asp Asn Asn Thr Asn Gly Val Thr Val Ala Ala Asn Gly Asn His 
            20                  25                  30          


Glu Gly Phe Thr Ala Val Gln Thr Arg Gln Asn Pro His Pro His Val 
        35                  40                  45              


Ser Arg Asn Pro Tyr Gly His Asn Ala Gly Val Thr Asp Phe Leu Ser 
    50                  55                  60                  


Asn Val Ser Arg Phe Lys Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu 
65                  70                  75                  80  


Gln Phe Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Glu Ile Ala 
                85                  90                  95      


Lys Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro 
            100                 105                 110         


Cys Ala Ser Glu Gln Ser Arg Lys Asp Cys Glu Ala Ile Cys Lys Leu 
        115                 120                 125             


Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg Cys His Met Asp Asp 
    130                 135                 140                 


Ala Arg Ile Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val Ile 
145                 150                 155                 160 


Gly Thr Ser Ser Tyr Leu Arg Glu His Ser His Gly Lys Asp Met Thr 
                165                 170                 175     


Tyr Ile Lys Asn Thr Ala Ile Glu Val Ile Asn Phe Val Lys Ser Lys 
            180                 185                 190         


Gly Ile Glu Val Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu 
        195                 200                 205             


Val Asp Leu Leu Ser Ile Tyr Ser Ala Val Asp Gln Val Gly Val Asn 
    210                 215                 220                 


Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Ser Pro Arg Gln Val 
225                 230                 235                 240 


Tyr Glu Leu Val Arg Val Leu Arg Gly Val Val Lys Cys Asp Ile Glu 
                245                 250                 255     


Ile His Leu His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala Tyr Cys 
            260                 265                 270         


Ala Leu Glu Gly Gly Ala Thr His Ile Asp Thr Ser Val Leu Gly Ile 
        275                 280                 285             


Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met Ala Arg Met 
    290                 295                 300                 


Ile Ala Ala Asp Arg Asp Tyr Val Leu Ser Lys Tyr Lys Leu Asp Lys 
305                 310                 315                 320 


Ile Lys Asp Ile Glu Asp Leu Val Ala Glu Ala Val Gln Val Asn Ile 
                325                 330                 335     


Pro Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe Thr His Lys Ala 
            340                 345                 350         


Gly Ile His Ala Lys Ala Ile Leu Asn Asn Pro Ser Thr Tyr Glu Ile 
        355                 360                 365             


Ile Asn Pro Ala Asp Phe Gly Met Thr Arg Tyr Val His Phe Ala Ser 
    370                 375                 380                 


Arg Leu Thr Gly Trp Asn Ala Ile Lys Ser Arg Ala Gln Gln Leu Asn 
385                 390                 395                 400 


Leu Asp Met Thr Asp Ala Gln Tyr Lys Glu Cys Thr Ala Lys Ile Lys 
                405                 410                 415     


Ala Leu Ala Asp Ile Arg Pro Ile Ala Val Asp Asp Ala Asp Ser Ile 
            420                 425                 430         


Ile Arg Ala Tyr His Arg Asn Ile Lys Leu Gly Glu Asp Lys Pro Leu 
        435                 440                 445             


Leu Asp Leu Thr Glu Glu Gln Thr Ala Glu Phe Ala Ala Lys Gln Lys 
    450                 455                 460                 


Glu Met Ala Glu Asn Gly Val Glu Val Ser Ala 
465                 470                 475 


<210>  16
<211>  1425
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  16
atggcaaccg acaccggctc tcgcccgtgc tgttcttcgc acacgtcgga tgataataac       60

accaacggtg ttaccgtggc cgctaacggc aatcacgaag gcttcactgc agtgcagact      120

cgccaaaacc cccacccaca cgtttcccgc aacccatacg gtcacaacgc tggtgtaacc      180

gattttctct cgaacgtgtc ccgattcaaa attatcgagt ccacccttcg tgaaggcgaa      240

cagtttgcca acgctttctt cgacaccgag aagaagattg agatcgctaa ggcattggat      300

gatttcggcg tagactatat cgagctcacc tcgccatgcg catcagaaca gtctcgtaag      360

gattgtgaag ctatttgcaa gctgggcttg aaggccaaga tcctcaccca tattcgctgc      420

cacatggacg atgcacgtat cgcggttgag accggtgttg atggtgtcga cgttgtgatc      480

ggcacaagca gctacctgcg cgaacactcc cacggcaagg acatgaccta catcaagaac      540

accgccatcg aagtaatcaa cttcgttaag tcaaaaggca ttgaagtccg attctcctct      600

gaagacagct tccgatcaga tctggtggat ctgcttagca tctattccgc tgtcgaccag      660

gtgggcgtga accgtgtggg catcgcggat acggttggtt gcgcttcccc tcgtcaggtc      720

tacgagctgg tacgcgtgtt gcgtggagtg gtgaagtgcg atattgagat ccaccttcat      780

aacgacaccg gctgcgcgat cgcgaacgca tattgtgccc tcgaaggcgg agccacacac      840

attgacacct ccgtgttggg tattggtgaa cgcaatggca tcactcctct tggcggtttg      900

atggcccgca tgatcgcagc agatcgcgac tacgtccttt ctaaatataa acttgacaag      960

attaaagata tcgaggatct tgtcgcagag gccgtgcagg taaacatccc attcaataac     1020

ccgattaccg gtttctgtgc gttcacacac aaggcaggaa tccacgcgaa ggccattttg     1080

aacaatccct ccacatacga gatcatcaac ccagccgact tcggcatgac ccgttatgtt     1140

cattttgcct cccgcctcac cggatggaac gcaattaaat cacgcgcaca gcagcttaac     1200

ttggacatga ccgacgcgca gtacaaggag tgcaccgcaa aaatcaaagc actggcagat     1260

atccgtccaa tcgcagtcga cgatgcagac agcattatcc gcgcatacca ccgcaacatc     1320

aaactcggcg aggacaaacc cctgcttgat cttaccgaag agcagaccgc cgaattcgca     1380

gcgaagcaaa aagaaatggc ggaaaacgga gtggaagtgt ccgca                     1425


<210>  17
<211>  376
<212>  PRT
<213>  Anaeromyxobacter dehalogenans

<400>  17

Met Thr Lys Ser Thr Trp Lys Leu Ile Asp Ser Thr Leu Arg Glu Gly 
1               5                   10                  15      


Glu Gln Phe Ala His Gly Thr Phe Arg Thr Glu Asp Lys Leu Glu Ile 
            20                  25                  30          


Ala Arg Ala Leu Asp Thr Phe Gly Val Glu Tyr Val Glu Val Thr Ser 
        35                  40                  45              


Pro Ala Ala Ser Pro Gln Ser Gln Arg Asp Ala Val Gln Ile Val Lys 
    50                  55                  60                  


Leu Gly Leu Gly Ala Arg Val Ile Thr His Ser Arg Cys Val Leu Asp 
65                  70                  75                  80  


Asp Val Arg Ala Ala Ile Asp Thr Gly Val Arg Gly Ile Gly Leu Leu 
                85                  90                  95      


Phe Ala Thr Ser Arg Ile Leu Arg Glu Ser Ser His Gly Lys Ser Ile 
            100                 105                 110         


Gln Gln Ile Ile Asp Ala Met Gly Pro Pro Ile Glu Leu Ala Leu Lys 
        115                 120                 125             


Ala Gly Leu Glu Thr Arg Phe Ser Ala Glu Asp Ala Phe Arg Ser Glu 
    130                 135                 140                 


Val Thr Asp Leu Val Ala Val Tyr Gln Ala Ala Glu Arg Leu Gly Val 
145                 150                 155                 160 


His Arg Val Gly Ile Ala Asp Thr Val Gly Ile Ala Thr Pro Arg Gln 
                165                 170                 175     


Val Phe Ala Leu Val Arg Glu Ile Arg Arg Ala Val Arg Cys Asp Ile 
            180                 185                 190         


Gly Phe His Gly His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala Tyr 
        195                 200                 205             


Glu Ala Leu Ala Ala Gly Ala Thr His Val Asp Val Ala Val Leu Gly 
    210                 215                 220                 


Ile Gly Glu Arg Val Gly Ile Thr Pro Leu Gly Gly Ile Ile Ala Arg 
225                 230                 235                 240 


Met Phe Ser Ile Glu Pro Gln Ser Val Ala Glu Arg Tyr Arg Leu Gly 
                245                 250                 255     


Gln Leu Arg Glu Leu Glu Arg Leu Val Ala Arg Val Thr Gly Ile Glu 
            260                 265                 270         


Val Pro Phe Asn Asn Tyr Val Thr Gly Glu Thr Ala Tyr Ser His Lys 
        275                 280                 285             


Ala Gly Met His Leu Lys Ala Met Met Ala Asn Pro Gly Ser Tyr Glu 
    290                 295                 300                 


Ile Ile Pro Pro Glu Ala Phe Gly Leu Thr Arg Arg Leu Ile Leu Gly 
305                 310                 315                 320 


Ser Arg Leu Thr Gly Arg His Ala Ile Ala Tyr Arg Ala Arg Glu Met 
                325                 330                 335     


Gly Ile Thr Phe Gly Glu Ser Glu Leu Lys Ala Leu Thr Lys Arg Ile 
            340                 345                 350         


Lys Glu Leu Ala Asp Ala Gly Glu Leu Ser Glu Glu Gln Ile Asp Arg 
        355                 360                 365             


Val Leu Arg Asp Trp Val Thr Ala 
    370                 375     


<210>  18
<211>  1128
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  18
atgaccaaat ccacctggaa actcatcgat tccacactcc gtgaaggaga acagtttgca       60

catggaacct tccgtaccga agacaaactg gagattgctc gcgcactcga tactttcgga      120

gtggaatacg tagaggtgac ctcaccggct gcgtcgccgc agagccagcg cgatgcagtc      180

cagattgtca agctcggctt gggcgcacgc gtcatcactc actcgcgctg cgttctggac      240

gacgtccgtg ccgcgattga caccggcgtt cgaggcatcg gcttgctgtt cgctacctca      300

cgcattttgc gtgaatctag ccatggtaag agcatccaac agattattga cgcgatgggc      360

ccaccaatcg aactggccct caaggcgggc ctggaaactc gcttctccgc agaggacgct      420

tttcgttctg aagtgacgga tctggtggcc gtttaccagg cagctgaacg tctgggcgtg      480

caccgcgttg gcatcgcaga caccgttggc atcgctacgc ctcgccaggt gttcgcgctg      540

gtgcgcgaga tccgtcgcgc tgttcgctgt gacatcggct tccacggcca caatgatact      600

ggctgtgcca tcgcaaacgc ctacgaggca ctggcagcgg gcgcgacaca tgtggatgtc      660

gctgttctcg gtatcggaga gcgcgtcggc atcaccccgt tgggcggtat cattgcgcgc      720

atgttttcca tcgaacctca atccgtcgca gagcgttacc gtctgggaca gctccgtgag      780

ctcgagcgtc tcgtcgcccg agtcacaggt atcgaagtgc ccttcaacaa ctacgtcacc      840

ggcgaaacgg cttactctca taaggcagga atgcatctca aagctatgat ggctaacccg      900

ggttcgtatg aaattatccc tcctgaagca ttcggcctta cccgtcgatt gatcttgggc      960

agccgcctta ccggccgcca cgctattgcc taccgtgccc gcgagatggg catcaccttc     1020

ggcgagtcgg aactgaaggc attgaccaag cgtattaaag aactggccga cgccggcgaa     1080

ctgtctgagg agcagatcga tcgcgtgctc cgcgattggg tgacggcg                  1128


<210>  19
<211>  418
<212>  PRT
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  19

Met Ser Val Ser Glu Ala Asn Gly Thr Glu Thr Ile Lys Pro Pro Met 
1               5                   10                  15      


Asn Gly Asn Pro Tyr Gly Pro Asn Pro Ser Asp Phe Leu Ser Arg Val 
            20                  25                  30          


Asn Asn Phe Ser Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe 
        35                  40                  45              


Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Gln Ile Ala Lys Ala 
    50                  55                  60                  


Leu Asp Asn Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro Val Ala 
65                  70                  75                  80  


Ser Glu Gln Ser Arg Gln Asp Cys Glu Ala Ile Cys Lys Leu Gly Leu 
                85                  90                  95      


Lys Cys Lys Ile Leu Thr His Ile Arg Cys His Met Asp Asp Ala Arg 
            100                 105                 110         


Val Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val Ile Gly Thr 
        115                 120                 125             


Ser Gln Tyr Leu Arg Lys Tyr Ser His Gly Lys Asp Met Thr Tyr Ile 
    130                 135                 140                 


Ile Asp Ser Ala Thr Glu Val Ile Asn Phe Val Lys Ser Lys Gly Ile 
145                 150                 155                 160 


Glu Val Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp 
                165                 170                 175     


Leu Leu Ser Leu Tyr Lys Ala Val Asp Lys Ile Gly Val Asn Arg Val 
            180                 185                 190         


Gly Ile Ala Asp Thr Val Gly Cys Ala Thr Pro Arg Gln Val Tyr Asp 
        195                 200                 205             


Leu Ile Arg Thr Leu Arg Gly Val Val Ser Cys Asp Ile Gln Cys His 
    210                 215                 220                 


Phe His Asn Asp Thr Gly Met Ala Ile Ala Asn Ala Tyr Cys Ala Leu 
225                 230                 235                 240 


Glu Ala Gly Ala Thr His Ile Asp Thr Ser Ile Leu Gly Ile Gly Glu 
                245                 250                 255     


Arg Asn Gly Ile Thr Pro Leu Gly Ala Leu Leu Ala Arg Met Tyr Val 
            260                 265                 270         


Thr Asp Arg Glu Tyr Ile Thr His Lys Tyr Lys Leu Asn Gln Leu Arg 
        275                 280                 285             


Glu Leu Glu Asn Leu Val Ala Asp Ala Val Glu Val Gln Ile Pro Phe 
    290                 295                 300                 


Asn Asn Tyr Ile Thr Gly Met Cys Ala Phe Thr His Lys Ala Gly Ile 
305                 310                 315                 320 


His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu Ile Leu Lys 
                325                 330                 335     


Pro Glu Asp Phe Gly Met Ser Arg Tyr Val His Val Gly Ser Arg Leu 
            340                 345                 350         


Thr Gly Trp Asn Ala Ile Lys Ser Arg Ala Glu Gln Leu Asn Leu His 
        355                 360                 365             


Leu Thr Asp Ala Gln Ala Lys Glu Leu Thr Val Arg Ile Lys Lys Leu 
    370                 375                 380                 


Ala Asp Val Arg Thr Leu Ala Met Asp Asp Val Asp Arg Val Leu Arg 
385                 390                 395                 400 


Glu Tyr His Ala Asp Leu Ser Asp Ala Asp Arg Ile Thr Lys Glu Ala 
                405                 410                 415     


Ser Ala 
        


<210>  20
<211>  1254
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  20
atgtccgttt ccgaagccaa tggcactgag actatcaagc ctcctatgaa cggaaacccc       60

tacggcccta acccatccga ctttctctcc cgcgtgaata acttctccat catcgaatcc      120

accctccgag aaggagagca attcgcaaac gctttctttg acaccgagaa gaaaatccaa      180

atcgccaagg cactggataa ctttggagtg gattacatcg agctgacctc acccgttgct      240

tctgaacagt cccgccaaga ctgcgaggct atctgcaagc tcggtctcaa atgtaagatt      300

ctgacccaca ttcgctgcca catggacgat gcccgtgtgg ccgtcgaaac tggcgtggat      360

ggcgttgacg tcgtcatcgg cacatcccag tacctccgca agtactcaca cggcaaggat      420

atgacctaca tcatcgattc cgcgacagaa gtgattaact ttgtcaagtc gaagggtatc      480

gaagtgcgct tctcctcaga agactccttc cgctcagatc tggtggatct tctctcgctg      540

tacaaggcgg ttgacaagat cggtgtcaat cgtgtcggaa ttgcagatac cgtaggctgc      600

gcaactcccc gtcaggttta cgatctgatc cgtactctcc gtggcgtggt ttcatgcgat      660

atccaatgcc atttccacaa cgacacggga atggctattg ccaacgcata ctgtgctttg      720

gaagcaggtg ctacacacat cgataccagc atcctgggca tcggagaacg caacggaatt      780

acgcccctgg gtgctctctt ggcgcgtatg tacgtgactg accgcgaata catcacccac      840

aagtataaat tgaatcaact gcgcgaactg gaaaaccttg ttgcggacgc tgtggaagtc      900

caaatcccgt ttaataacta tattaccggt atgtgcgcat tcacccacaa ggctggcatc      960

cacgcgaagg caattctcgc aaacccatct acttacgaga ttttgaaacc ggaagacttc     1020

ggtatgtcac gatatgttca cgtgggatcc cgcctgacgg gctggaacgc tatcaaatct     1080

cgtgccgaac agctcaatct gcacttgacc gatgcacagg caaaggagct gaccgtgcgc     1140

attaagaaat tggcggatgt ccgtaccctg gcgatggacg atgttgaccg cgttctccgc     1200

gaatatcacg ctgatctgag cgacgccgat cgaattacca aagaggcatc tgct           1254


<210>  21
<211>  463
<212>  PRT
<213>  Aspergillus niger

<400>  21

Met Cys Pro Gly Ala Asp His Glu Pro Asn Gly Gln Ala Asn Ala Ala 
1               5                   10                  15      


Asn Gly Arg Asn Gly Glu His Pro Gly Phe Thr Ala Val Glu Thr Arg 
            20                  25                  30          


Gln Asn Pro His Pro Ser Val Ser Arg Asn Pro Tyr Gly His Asn Val 
        35                  40                  45              


Gly Val Thr Asp Phe Leu Ser Asn Val Ser Arg Phe Gln Ile Ile Glu 
    50                  55                  60                  


Ser Thr Leu Arg Glu Gly Glu Gln Phe Ala Asn Ala Phe Phe Asp Thr 
65                  70                  75                  80  


Glu Lys Lys Ile Glu Ile Ala Lys Ala Leu Asp Glu Phe Gly Val Asp 
                85                  90                  95      


Tyr Ile Glu Leu Thr Ser Pro Cys Ala Ser Glu Gln Ser Arg Lys Asp 
            100                 105                 110         


Cys Glu Ala Ile Cys Lys Leu Gly Leu Lys Ala Lys Ile Leu Thr His 
        115                 120                 125             


Ile Arg Cys His Met Asp Asp Ala Arg Ile Ala Val Glu Thr Gly Val 
    130                 135                 140                 


Asp Gly Val Asp Val Val Ile Gly Thr Ser Ser Tyr Leu Arg Glu His 
145                 150                 155                 160 


Ser His Gly Lys Asp Met Thr Tyr Ile Lys Asn Thr Ala Ile Glu Val 
                165                 170                 175     


Ile Glu Phe Val Lys Ser Lys Gly Ile Glu Ile Arg Phe Ser Ser Glu 
            180                 185                 190         


Asp Ser Phe Arg Ser Asp Leu Val Asp Leu Leu Ser Ile Tyr Ser Ala 
        195                 200                 205             


Val Asp Lys Val Gly Val Asn Arg Val Gly Ile Ala Asp Thr Val Gly 
    210                 215                 220                 


Cys Ala Ser Pro Arg Gln Val Tyr Glu Leu Val Arg Val Leu Arg Gly 
225                 230                 235                 240 


Val Val Ser Cys Asp Ile Glu Thr His Phe His Asn Asp Thr Gly Cys 
                245                 250                 255     


Ala Ile Ala Asn Ala Tyr Cys Ala Leu Glu Ala Gly Ala Thr His Ile 
            260                 265                 270         


Asp Thr Ser Val Leu Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu 
        275                 280                 285             


Gly Gly Leu Met Ala Arg Met Met Val Ala Asp Pro Glu Tyr Val Lys 
    290                 295                 300                 


Gly Lys Tyr Arg Leu Glu Lys Leu Lys Asp Ile Glu Asp Leu Val Ala 
305                 310                 315                 320 


Glu Ala Val Glu Val Asn Ile Pro Phe Asn Asn Tyr Ile Thr Gly Phe 
                325                 330                 335     


Cys Ala Phe Thr His Lys Ala Gly Ile His Ala Lys Ala Ile Leu Asn 
            340                 345                 350         


Asn Pro Ser Thr Tyr Glu Ile Ile Asn Pro Ala Asp Phe Gly Met Ser 
        355                 360                 365             


Arg Tyr Val His Phe Ala Ser Arg Leu Thr Gly Trp Asn Ala Ile Lys 
    370                 375                 380                 


Ser Arg Ala Gln Gln Leu Lys Ile Glu Met Thr Asp Asp Gln Tyr Lys 
385                 390                 395                 400 


Glu Cys Thr Ala Lys Ile Lys Ala Leu Ala Asp Ile Arg Pro Ile Ala 
                405                 410                 415     


Val Asp Asp Ala Asp Ser Ile Ile Arg Ala Tyr Tyr Arg Asn Leu Lys 
            420                 425                 430         


Leu Gly Glu Asn Lys Pro Leu Leu Asp Leu Thr Ala Asp Glu Gln Ala 
        435                 440                 445             


Gln Phe Ala Ala Lys Glu Lys Glu Leu Ala Ala Gln Ala Ser Ala 
    450                 455                 460             


<210>  22
<211>  1389
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  22
atgtgcccgg gcgccgacca tgagcctaac ggccaggcaa acgctgcaaa cggacgcaat       60

ggcgagcacc ccggatttac cgctgttgag acgcgtcaaa acccacatcc ttctgttagc      120

cgtaacccgt acggtcacaa cgtaggtgtc acagatttct tgtccaacgt aagccgcttt      180

cagattattg aatctaccct tcgcgagggc gagcagttcg ccaacgcctt ctttgacacc      240

gaaaaaaaaa ttgagatcgc caaagcactt gatgagttcg gcgtggatta catcgagctc      300

acttctcctt gcgcatccga acagtctcgc aaagactgcg aggcaatttg caagttgggt      360

ctcaaagcga aaatccttac gcacatccga tgccacatgg acgacgcacg aatcgcagtt      420

gaaaccggtg ttgatggcgt ggacgtagtt atcggtacct ccagctacct ccgcgaacac      480

tcacacggca aggatatgac ctacatcaaa aacaccgcga ttgaagtaat cgagtttgtc      540

aaatccaagg gaatcgagat ccgcttctca tctgaggatt ccttccgcag cgatctcgtt      600

gatctgcttt ccatttattc tgctgttgac aaggtaggtg tcaatcgcgt cggtatcgcg      660

gatacagtgg gttgtgcctc ccctcgacaa gtgtacgaac tcgtgcgtgt gttgcgcggt      720

gtcgtgtcct gtgatattga gacccacttt cacaacgata ccggttgcgc aatcgcgaat      780

gcttactgcg ctctggaagc cggagcgacc catattgata cctccgtgtt gggcattgga      840

gaacgcaacg gtattacacc cctcggtggt ctgatggcac gtatgatggt cgccgacccc      900

gaatacgtga aaggcaagta ccgcctggag aagctcaaag atatcgagga cctcgtggcc      960

gaagcagtgg aggttaatat tccctttaac aattatatca ctggtttttg cgccttcact     1020

cacaaagccg gtatccacgc taaggccatc cttaacaacc cgagcacgta cgaaattatt     1080

aatccagctg acttcggcat gtcacgttac gttcacttcg cttcgcgcct tacgggatgg     1140

aacgctatta agtcccgtgc ccagcagctt aagattgaga tgacggacga ccaatataag     1200

gaatgcaccg ctaagatcaa agctctggcg gatattcgtc caatcgctgt ggacgacgcg     1260

gacagcatta tccgcgccta ctaccgaaac ctgaaactcg gcgaaaacaa gccactgctt     1320

gatctgacgg cggacgagca ggctcaattc gcggccaaag agaaggaact cgcggctcaa     1380

gcatcagcg                                                             1389


<210>  23
<211>  382
<212>  PRT
<213>  Marinithermus hydrothermalis

<400>  23

Met Thr Asn Pro Arg Ser Leu Gly Ser Trp Ala Ile Ile Asp Ser Thr 
1               5                   10                  15      


Leu Arg Glu Gly Glu Gln Phe Glu Arg Ala His Phe Ser Thr Gly Asp 
            20                  25                  30          


Lys Val Glu Ile Ala Arg Ala Leu Asp Ala Phe Gly Ile Glu Tyr Ile 
        35                  40                  45              


Glu Val Thr Thr Pro Val Ala Ser Pro Gln Ser Ala Arg Asp Ala Lys 
    50                  55                  60                  


Val Leu Ala Asn Leu Asn Leu Lys Ala Lys Val Ile Thr His Ile Gln 
65                  70                  75                  80  


Cys Arg Lys Glu Ala Ala Trp Ala Ala Leu Glu Thr Gly Val Gln Gly 
                85                  90                  95      


Ile Asp Leu Leu Phe Gly Thr Ser Lys Tyr Leu Arg Ala Ala His Gly 
            100                 105                 110         


Arg Asp Ile Pro Arg Ile Ile Glu Glu Ala Leu Glu Val Ile Glu Leu 
        115                 120                 125             


Ile Arg Glu Gln Ala Pro Glu Val Glu Val Arg Phe Ser Ala Glu Asp 
    130                 135                 140                 


Thr Phe Arg Ser Asp Glu His Asp Leu Leu Thr Val Tyr Arg Ser Val 
145                 150                 155                 160 


Ala Pro Tyr Val Asn Arg Val Gly Leu Ala Asp Thr Val Gly Val Ala 
                165                 170                 175     


Thr Pro Arg Gln Val Tyr Ala Leu Val Arg Glu Val Arg Arg Ala Val 
            180                 185                 190         


Gly Pro Glu Val Asp Ile Glu Phe His Gly His Asn Asp Thr Gly Cys 
        195                 200                 205             


Ala Val Ala Asn Ala Tyr Glu Ala Leu Glu Ala Gly Ala Thr His Val 
    210                 215                 220                 


Asp Thr Ser Ile Leu Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu 
225                 230                 235                 240 


Gly Gly Phe Leu Ala Arg Met Tyr Thr Leu Gln Pro Glu Tyr Val Ala 
                245                 250                 255     


Gly Lys Tyr Arg Leu Glu Met Leu Pro Glu Leu Asp Arg Met Ile Ala 
            260                 265                 270         


Arg Met Thr Gly Ile Gln Ile Pro Phe Asn Asn Tyr Ile Thr Gly Glu 
        275                 280                 285             


Ser Ala Phe Ser His Lys Ala Gly Met His Leu Lys Ala Ile Tyr Leu 
    290                 295                 300                 


Asn Pro Gln Ala Tyr Glu Ala Tyr Pro Pro Glu Ala Phe Gly Leu Ser 
305                 310                 315                 320 


Arg Lys Leu Ile Ile Gly Ser Arg Leu Thr Gly Arg Ala Ala Ile Lys 
                325                 330                 335     


Lys Arg Ala Glu Glu Leu Gly Leu Ser Phe Gly Glu Glu Glu Leu Gln 
            340                 345                 350         


Arg Ile Thr His Arg Ile Lys Ala Leu Ala Asp Gln Gly Thr Leu Thr 
        355                 360                 365             


Leu Glu Glu Leu Asp Arg Ile Leu Arg Glu Trp Val Leu Ala 
    370                 375                 380         


<210>  24
<211>  1146
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  24
atgaccaatc ctcgtagcct gggctcatgg gcaatcattg actcgacctt gcgcgaaggt       60

gaacagttcg agcgcgcaca cttcagcacc ggagataagg tggagattgc ccgtgcgctt      120

gacgcatttg gtatcgaata cattgaggta actactccgg tagcatctcc acagtccgcg      180

cgtgatgcaa aggtgctcgc aaatctcaac cttaaagcca aggttatcac acacatccaa      240

tgccgcaagg aagcagcttg ggccgccctc gaaaccggag tgcaaggtat cgacctcctg      300

ttcggtacct ctaagtacct gcgcgcggcc cacggacgtg atattccacg cattatcgag      360

gaagccttgg aagtcatcga gttgatccgc gagcaggccc ccgaagtgga agtgcgattt      420

tcagcggagg ataccttccg ctccgatgag cacgaccttc tgacagttta ccgtagcgtt      480

gctccttacg tgaaccgcgt gggcctggcg gacacagtag gcgtagccac tcctcgtcaa      540

gtctatgcat tggtgcgtga ggtccgacga gccgtcggcc ctgaagtcga cattgaattt      600

cacggccaca atgacaccgg ctgtgccgtg gcgaacgcat acgaggcctt ggaagccggc      660

gccacgcacg tggatactag catcctgggc atcggagaac gtaacggaat tactcctctt      720

ggcggctttt tggcccgcat gtacaccctc cagcctgagt atgttgcggg aaaataccgc      780

cttgaaatgt tgcctgagtt ggatcgcatg atcgcccgta tgaccggcat ccagattccc      840

ttcaataact acatcactgg cgagagcgca ttctcacaca aagcaggaat gcatctgaag      900

gctatctacc tgaacccaca ggcgtacgag gcgtaccctc cggaagcctt cggcttgtcc      960

cgcaaattga ttattggatc ccgtttgact ggtcgtgcag caattaagaa gcgcgccgag     1020

gaactgggat tgtcttttgg cgaagaggag ttgcaacgaa tcacccatcg tatcaaggct     1080

ctcgctgatc agggtacctt gacactggag gaacttgatc gtattctgcg tgaatgggta     1140

cttgct                                                                1146


<210>  25
<211>  418
<212>  PRT
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  25

Met Ser Val Ser Glu Ala Asn Gly Thr Glu Thr Ile Lys Pro Pro Met 
1               5                   10                  15      


Asn Gly Asn Pro Tyr Gly Pro Asn Pro Ser Asp Phe Leu Ser Arg Val 
            20                  25                  30          


Asn Asn Phe Ser Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe 
        35                  40                  45              


Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Gln Ile Ala Lys Ala 
    50                  55                  60                  


Leu Asp Asn Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro Val Ala 
65                  70                  75                  80  


Ser Glu Gln Ser Arg Gln Asp Cys Glu Ala Ile Cys Lys Leu Gly Leu 
                85                  90                  95      


Lys Cys Lys Ile Leu Thr His Ile Arg Cys His Met Asp Asp Ala Arg 
            100                 105                 110         


Val Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val Ile Gly Thr 
        115                 120                 125             


Ser Gln Tyr Leu Arg Lys Tyr Ser His Gly Lys Asp Met Thr Tyr Ile 
    130                 135                 140                 


Ile Asp Ser Ala Thr Glu Val Ile Asn Phe Val Lys Ser Lys Gly Ile 
145                 150                 155                 160 


Glu Val Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp 
                165                 170                 175     


Leu Leu Ser Leu Tyr Lys Ala Val Asp Lys Ile Gly Val Asn Arg Val 
            180                 185                 190         


Gly Ile Ala Asp Thr Val Gly Cys Ala Thr Pro Arg Gln Val Tyr Asp 
        195                 200                 205             


Leu Ile Arg Thr Leu Arg Gly Val Val Ser Cys Asp Ile Glu Cys His 
    210                 215                 220                 


Phe His Asn Asp Thr Gly Met Ala Ile Ala Asn Ala Tyr Cys Ala Leu 
225                 230                 235                 240 


Glu Ala Gly Ala Thr His Ile Asp Thr Ser Ile Leu Gly Ile Gly Glu 
                245                 250                 255     


Arg Asn Gly Ile Thr Pro Leu Gly Ala Leu Leu Ala Arg Met Tyr Val 
            260                 265                 270         


Thr Asp Arg Glu Tyr Ile Thr His Lys Tyr Lys Leu Asn Gln Leu Lys 
        275                 280                 285             


Glu Leu Glu Asn Leu Val Ala Asp Ala Val Glu Val Gln Ile Pro Phe 
    290                 295                 300                 


Asn Asn Tyr Ile Thr Gly Met Cys Ala Phe Thr His Lys Ala Gly Ile 
305                 310                 315                 320 


His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu Ile Leu Lys 
                325                 330                 335     


Pro Glu Asp Phe Gly Met Ser Arg Tyr Val His Val Gly Ser Arg Leu 
            340                 345                 350         


Thr Gly Trp Asn Ala Ile Lys Ser Arg Ala Glu Gln Leu Asn Leu His 
        355                 360                 365             


Leu Thr Asp Ala Gln Ala Lys Glu Leu Thr Val Arg Ile Lys Lys Leu 
    370                 375                 380                 


Ala Asp Val Arg Thr Leu Ala Met Asp Asp Val Asp Arg Val Leu Arg 
385                 390                 395                 400 


Glu Tyr His Ala Asp Leu Ser Asp Ala Asp Arg Ile Thr Lys Glu Ala 
                405                 410                 415     


Ser Ala 
        


<210>  26
<211>  1254
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  26
atgtcagtat ctgaagctaa tggcaccgaa acaatcaagc ctccgatgaa cggcaacccc       60

tatggcccta acccgtccga ttttttgtcc cgcgtcaata atttttcaat tatcgaaagc      120

acccttcgtg aaggcgaaca gtttgctaac gcattcttcg ataccgagaa gaagatccag      180

atcgcaaagg cactcgataa ctttggcgtc gattacatcg agctcactag cccagtggca      240

agcgagcagt cacgccaaga ttgtgaagcg atttgcaagc tcggcctgaa gtgcaagatc      300

ttgacccaca tccgttgcca tatggacgac gcacgcgtcg ccgtagagac tggcgttgac      360

ggtgttgacg tagtgattgg cacatcacaa tatctccgca agtattccca tggaaaagat      420

atgacatata ttattgattc cgctacagag gttattaact ttgtcaaatc caagggaatc      480

gaagtgcgct tttcgtccga agattcgttc cgttccgact tggtggatct cctgtccctc      540

tacaaggcgg tcgacaagat cggtgttaac cgcgtcggca ttgccgacac ggttggttgt      600

gcaacacccc gacaagtgta cgatcttatc cgcaccctgc gcggcgtggt ctcatgtgac      660

atcgaatgtc atttccacaa cgatacagga atggcgatcg caaacgcata ttgcgcactc      720

gaagccggag ctacgcatat cgacactagc atcctcggta ttggtgaacg caacggcatc      780

accccattgg gagcgctttt ggcccgtatg tacgtgactg atcgcgaata catcacccac      840

aaatacaaac tgaaccaact gaaggagctg gaaaaccttg tcgctgacgc tgttgaagta      900

cagattccgt tcaacaatta tatcacaggc atgtgtgcat tcacccacaa ggctggaatc      960

cacgctaaag ccatcctcgc gaacccatct acgtatgaaa tcctcaagcc tgaagacttc     1020

ggaatgtctc gctacgtcca tgttggctct cgcctcactg gatggaacgc aattaaatct     1080

cgcgcagaac agttgaattt gcacctgaca gacgcccagg ccaaggaact cactgtgcgc     1140

attaagaagc ttgctgatgt gcgtacattg gcgatggacg acgtagatcg cgtccttcga     1200

gagtaccacg cagacctgag cgatgctgac cgaattacaa aagaggcgtc cgct           1254


<210>  27
<211>  371
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  27

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  28
<211>  1113
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  28
atgttccgta gcgttgcgac gcgcctgtca gcgtgtcgcg gcctggcgtc taacgctgcc       60

cgcaaatcac tgaccatcgg tttgattccc ggagacggaa tcggcaagga agttattccc      120

gccggaaagc aagtccttga aaaccttaac tctaagcacg gcctctcatt taattttatt      180

gatttgtatg cgggattcca gactttccag gagaccggta aggcattgcc cgacgaaacc      240

gtgaaagtcc tgaaggaaca gtgccaagga gcattgttcg gtgcggtgca gtccccaacc      300

acaaaggtgg aaggttactc ctcacccatc gtcgcgttgc gccgagaaat gggcctgttc      360

gcgaatgtcc gcccagtcaa gtcagtggaa ggcgagaagg gtaaaccaat tgacatggtt      420

atcgtgcgtg aaaacaccga ggacctctac atcaaaattg aaaagactta catcgataag      480

gcaactggaa ctcgcgtagc ggatgcgacg aaacgtatca gcgaaatcgc tacccgtcgc      540

attgccacta ttgccctgga cattgcgttg aagcgccttc aaacgcgcgg ccaagctact      600

ctcaccgtca cgcataaatc caacgtgctg tcccagagcg acggtctgtt ccgtgagatt      660

tgcaaggaag tgtatgaatc taacaaagat aaatatggac aaatcaaata taacgagcag      720

attgtggact caatggtcta tcgcttgttc cgcgagcctc aatgcttcga cgtcattgtt      780

gctcccaatc tgtacggaga tatcctttcc gatggtgccg ccgcgcttgt aggctcactg      840

ggcgtggttc cgtcggcaaa cgtaggtcca gaaatcgtga tcggagagcc atgtcatggt      900

tctgcaccag atattgctgg aaagggcatc gccaacccta tcgccaccat ccgttccacc      960

gccttgatgc tcgagtttct gggacataat gaagctgctc aggacattta caaagcggta     1020

gacgcaaacc tgcgtgaggg ttcaattaag actcccgacc tgggaggtaa agcaagcaca     1080

cagcaagtgg tcgatgatgt cctttctcgc ctt                                  1113


<210>  29
<211>  475
<212>  PRT
<213>  Trichophyton equinum

<400>  29

Met Ala Thr Asp Thr Gly Ser Arg Pro Cys Cys Ser Ser His Thr Gly 
1               5                   10                  15      


Asp Asp Asn Asn Thr Asn Gly Val Thr Ile Ala Pro Asn Gly Asn His 
            20                  25                  30          


Glu Gly Phe Thr Ala Val Gln Thr Arg Gln Asn Pro His Pro His Val 
        35                  40                  45              


Ser Arg Asn Pro Tyr Gly His Asn Ala Gly Val Thr Asp Phe Leu Ser 
    50                  55                  60                  


Asn Val Ser Arg Phe Lys Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu 
65                  70                  75                  80  


Gln Phe Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Glu Ile Ala 
                85                  90                  95      


Lys Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro 
            100                 105                 110         


Cys Ala Ser Glu Gln Ser Arg Lys Asp Cys Glu Ala Ile Cys Lys Leu 
        115                 120                 125             


Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg Cys His Met Asp Asp 
    130                 135                 140                 


Ala Arg Ile Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val Ile 
145                 150                 155                 160 


Gly Thr Ser Ser Tyr Leu Arg Glu His Ser His Gly Lys Asp Met Thr 
                165                 170                 175     


Tyr Ile Lys Asn Thr Ala Ile Glu Val Ile Asn Phe Val Lys Ser Lys 
            180                 185                 190         


Gly Ile Glu Val Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu 
        195                 200                 205             


Val Asp Leu Leu Ser Ile Tyr Ser Ala Val Asp Gln Val Gly Val Asn 
    210                 215                 220                 


Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Ser Pro Arg Gln Val 
225                 230                 235                 240 


Tyr Glu Leu Val Arg Val Leu Arg Gly Val Val Lys Cys Asp Ile Glu 
                245                 250                 255     


Ile His Leu His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala Tyr Cys 
            260                 265                 270         


Ala Leu Glu Gly Gly Ala Thr His Ile Asp Thr Ser Val Leu Gly Ile 
        275                 280                 285             


Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met Ala Arg Met 
    290                 295                 300                 


Ile Ala Ala Asp Arg Asp Tyr Val Leu Ser Lys Tyr Lys Leu Glu Lys 
305                 310                 315                 320 


Ile Lys Asp Ile Glu Asp Leu Val Ala Glu Ala Val Gln Val Asn Ile 
                325                 330                 335     


Pro Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe Thr His Lys Ala 
            340                 345                 350         


Gly Ile His Ala Lys Ala Ile Leu Asn Asn Pro Ser Thr Tyr Glu Ile 
        355                 360                 365             


Ile Asn Pro Ala Asp Phe Gly Met Thr Arg Tyr Val His Phe Ala Ser 
    370                 375                 380                 


Arg Leu Thr Gly Trp Asn Ala Ile Lys Ser Arg Ala Gln Gln Leu Asn 
385                 390                 395                 400 


Leu Asp Met Thr Asp Ala Gln Tyr Lys Glu Cys Thr Ala Lys Ile Lys 
                405                 410                 415     


Ala Leu Ala Asp Ile Arg Pro Ile Ala Val Asp Asp Ala Asp Ser Ile 
            420                 425                 430         


Ile Arg Ala Tyr His Arg Asn Ile Lys Leu Gly Glu Asn Lys Pro Leu 
        435                 440                 445             


Leu Glu Leu Thr Glu Glu Gln Thr Ala Glu Phe Ala Ala Lys Glu Lys 
    450                 455                 460                 


Glu Leu Ala Glu Asn Gly Val Glu Ala Ser Ala 
465                 470                 475 


<210>  30
<211>  1425
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  30
atggctaccg acaccggttc tcgaccttgc tgcagcagcc atactggcga tgacaacaac       60

acaaatggcg ttaccatcgc gcccaacggt aaccacgaag gttttactgc tgtgcagaca      120

cgccagaatc cacacccaca tgtttctcgc aacccatacg gtcataacgc cggtgtgaca      180

gactttctta gcaatgtatc tcgcttcaag atcatcgagt ccacgctccg tgaaggtgag      240

caattcgcaa acgccttctt cgacaccgag aaaaaaatcg aaatcgccaa agcactggac      300

gattttggag tggactacat cgaacttact tccccatgtg cgtctgagca gtcacgtaag      360

gattgcgaag ctatctgtaa gttgggcctg aaggcaaaga tccttaccca catccgctgc      420

cacatggatg atgcccgtat cgcggtggaa accggagttg acggcgttga tgtggtgatt      480

ggcacttcct cctacctccg agaacactcg cacggtaagg atatgactta catcaaaaac      540

accgcgatcg aggtgattaa cttcgttaaa tccaagggca tcgaggttcg cttttcatcc      600

gaggactcct ttcgatccga tctggtggat ctgttgtcga tctactccgc tgtcgaccag      660

gttggagtta accgtgtggg tattgcagac accgttggtt gtgcttcgcc acgccaggtc      720

tacgagctcg tgcgcgtact gcgcggtgtc gtcaaatgtg atatcgaaat ccacctccac      780

aacgacaccg gctgcgccat cgcgaacgcc tactgtgcac tcgagggtgg tgcaacacac      840

atcgacacca gcgtacttgg catcggcgaa cgcaacggca tcacccccct cggaggcctg      900

atggcccgca tgatcgcagc ggatcgtgac tacgttcttt ctaaatataa gctggagaaa      960

attaaagata tcgaagatct cgtagcagag gccgtacagg tcaatatccc gttcaacaac     1020

cctattaccg gcttttgtgc tttcacgcat aaggctggca tccacgcgaa agctatcctc     1080

aacaacccat cgacctacga gatcatcaat cccgcggatt ttggcatgac ccgttacgtg     1140

cattttgcct cccgcctgac tggatggaat gcaattaaat cacgtgcaca gcagctcaat     1200

ttggatatga ccgatgcgca gtacaaggaa tgcacagcta agatcaaggc actcgctgat     1260

attcgcccta tcgcagttga cgacgcggac tctatcatcc gagcatacca ccgaaatatc     1320

aagttgggag aaaataagcc cctgctggag cttaccgaag aacagacagc ggaattcgcg     1380

gcaaaggaga aggagctcgc agagaacggt gtcgaagcat ccgcg                     1425


<210>  31
<211>  469
<212>  PRT
<213>  Penicillium brasilianum

<400>  31

Met Cys Pro Gly Ala Asp Ser Glu Pro Asn Gly Gln Val Asn Gly Ala 
1               5                   10                  15      


Asn Gly Ala Asn Gly Ala Asp His Glu Gly Phe Thr Gly Ile Glu Thr 
            20                  25                  30          


Arg Gln Asn Pro His Pro Ser Ala Ser Arg Asn Pro Tyr Gly His Asn 
        35                  40                  45              


Val Gly Val Thr Asp Phe Leu Ser Asn Val Ser Arg Phe Lys Ile Ile 
    50                  55                  60                  


Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe Ala Asn Ala Phe Phe Asp 
65                  70                  75                  80  


Thr Glu Lys Lys Ile Glu Ile Ala Lys Ala Leu Asp Asp Phe Gly Val 
                85                  90                  95      


Asp Tyr Ile Glu Leu Thr Ser Pro Cys Ala Ser Glu Gln Ser Arg Ala 
            100                 105                 110         


Asp Cys Glu Ala Ile Cys Lys Leu Gly Leu Lys Ala Lys Ile Leu Thr 
        115                 120                 125             


His Ile Arg Cys His Met Asp Asp Ala Arg Val Ala Val Glu Thr Gly 
    130                 135                 140                 


Val Asp Gly Val Asp Val Val Ile Gly Thr Ser Ser Tyr Leu Arg Glu 
145                 150                 155                 160 


His Ser His Gly Lys Asp Met Thr Tyr Ile Lys Asn Thr Ala Ile Glu 
                165                 170                 175     


Val Ile Glu Phe Val Lys Ser Lys Gly Ile Glu Ile Arg Phe Ser Ser 
            180                 185                 190         


Glu Asp Ser Phe Arg Ser Asp Leu Val Asp Leu Leu Ser Ile Tyr Ser 
        195                 200                 205             


Ala Val Asp Lys Val Gly Val Gln Arg Val Gly Ile Ala Asp Thr Val 
    210                 215                 220                 


Gly Cys Ala Ser Pro Arg Gln Val Tyr Glu Leu Val Arg Val Leu Arg 
225                 230                 235                 240 


Gly Val Val Gly Cys Asp Ile Glu Thr His Phe His Asn Asp Thr Gly 
                245                 250                 255     


Cys Ala Ile Ala Asn Ala Tyr Cys Ala Leu Glu Ala Gly Ala Thr His 
            260                 265                 270         


Ile Asp Thr Ser Val Leu Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro 
        275                 280                 285             


Leu Gly Gly Leu Met Ala Arg Met Met Val Ala Asp Pro Glu Tyr Val 
    290                 295                 300                 


Lys Gly Lys Tyr Lys Leu Glu Lys Leu Lys Asp Ile Glu Asp Leu Val 
305                 310                 315                 320 


Ala Glu Ala Val Gln Val Asn Ile Pro Phe Asn Asn Tyr Ile Thr Gly 
                325                 330                 335     


Phe Cys Ala Phe Thr His Lys Ala Gly Ile His Ala Lys Ala Ile Leu 
            340                 345                 350         


Asn Asn Pro Ser Thr Tyr Glu Ile Ile Asn Pro Ala Asp Phe Gly Met 
        355                 360                 365             


Thr Arg Tyr Val His Phe Ala Ser Arg Leu Thr Gly Trp Asn Ala Ile 
    370                 375                 380                 


Lys Ser Arg Cys Gln Gln Leu Lys Ile Asp Leu Thr Asp Ala Gln Ala 
385                 390                 395                 400 


Lys Glu Cys Thr Ala Lys Ile Lys Ala Leu Ala Asp Ile Arg Pro Ile 
                405                 410                 415     


Ala Val Asp Asp Ala Asp Ser Ile Ile Arg Ala Tyr Ala Arg Asn Leu 
            420                 425                 430         


Lys Leu Gly Glu Asp Lys Pro Leu Met Asp Leu Thr Ala Glu Glu Gln 
        435                 440                 445             


Ala Gln Phe Ala Ala Lys Glu Lys Glu Ile Ala Leu Glu Ala Glu Lys 
    450                 455                 460                 


Asn Gly Ile Ala Val 
465                 


<210>  32
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  32
atgtgcccgg gcgcagattc agagccaaat ggacaggtga acggcgccaa cggtgccaac       60

ggcgcagatc atgaaggatt taccggcatc gagacccgac aaaacccaca tccaagcgct      120

tcacgcaacc cctacggcca taacgtggga gtcaccgact ttttgtctaa cgtgtctcgc      180

ttcaagatta tcgaatccac actccgcgag ggtgaacagt tcgccaacgc attcttcgat      240

actgaaaaaa agatcgaaat tgccaaagca ctggacgact tcggagttga ctacattgaa      300

ctgacatccc cttgtgcgag cgaacagtcc cgcgctgatt gcgaagcgat ctgcaagttg      360

ggcctgaagg caaagatctt gactcatatt cgctgccaca tggacgacgc acgagtcgcg      420

gtcgagaccg gagtggatgg cgtcgacgtg gtcatcggta cttcgtccta cttgcgcgag      480

catagccacg gaaaggacat gacctatatc aagaacacgg caatcgaagt aatcgagttc      540

gtgaagtcca aaggtatcga gatccgcttc tcctcggaag actctttccg ctccgatctg      600

gtagacctcc tgtccatcta ctctgccgtg gacaaagttg gcgtacaacg tgtgggcatc      660

gcggacactg tgggctgcgc ttcccctcgc caggtgtacg agcttgttcg cgttctgcgc      720

ggcgtagtcg gctgcgatat tgagacccat ttccataacg ataccggatg cgcaatcgcg      780

aatgcgtact gtgctcttga agcgggtgct acccacatcg acacgagcgt tctgggtatc      840

ggtgagcgta acggcatcac cccgctgggt ggtctcatgg cgcgtatgat ggtcgcggac      900

ccggaatacg tcaaaggcaa gtacaaattg gagaaactca aggacatcga ggaccttgtg      960

gcggaagcgg tacaagtgaa cattcctttt aacaattaca tcacgggttt ctgcgctttt     1020

actcacaagg ctggtattca cgcaaaggca atcttgaaca acccttctac ctacgaaatc     1080

atcaatccgg ctgattttgg catgacccgc tacgtacact ttgcgtctcg cctgacaggt     1140

tggaatgcga tcaagtcacg ctgccaacag ttgaagattg atcttacgga tgcgcaggca     1200

aaggaatgta cagcgaagat taaggcgctt gcagacatcc gcccaattgc ggtggacgac     1260

gccgactcta tcatccgcgc ctacgcacgc aacctcaagt tgggcgagga taaaccactg     1320

atggatctta cagccgaaga acaggcacaa tttgcagcca aagagaagga gattgctttg     1380

gaggcagaga aaaatggaat cgcagtg                                         1407


<210>  33
<211>  684
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  33

Met Phe His Ser Ser Arg Ala Trp Leu Lys Gly Gln Asn Leu Thr Glu 
1               5                   10                  15      


Lys Ile Val Gln Ser Tyr Ala Val Asn Leu Pro Glu Gly Lys Val Val 
            20                  25                  30          


His Ser Gly Asp Tyr Val Ser Ile Lys Pro Ala His Cys Met Ser His 
        35                  40                  45              


Asp Asn Ser Trp Pro Val Ala Leu Lys Phe Met Gly Leu Gly Ala Thr 
    50                  55                  60                  


Lys Ile Lys Asn Pro Ser Gln Ile Val Thr Thr Leu Asp His Asp Ile 
65                  70                  75                  80  


Gln Asn Lys Ser Glu Lys Asn Leu Thr Lys Tyr Lys Asn Ile Glu Asn 
                85                  90                  95      


Phe Ala Lys Lys His His Ile Asp His Tyr Pro Ala Gly Arg Gly Ile 
            100                 105                 110         


Gly His Gln Ile Met Ile Glu Glu Gly Tyr Ala Phe Pro Leu Asn Met 
        115                 120                 125             


Thr Val Ala Ser Asp Ser His Ser Asn Thr Tyr Gly Gly Leu Gly Ser 
    130                 135                 140                 


Leu Gly Thr Pro Ile Val Arg Thr Asp Ala Ala Ala Ile Trp Ala Thr 
145                 150                 155                 160 


Gly Gln Thr Trp Trp Gln Ile Pro Pro Val Ala Gln Val Glu Leu Lys 
                165                 170                 175     


Gly Gln Leu Pro Gln Gly Val Ser Gly Lys Asp Ile Ile Val Ala Leu 
            180                 185                 190         


Cys Gly Leu Phe Asn Asn Asp Gln Val Leu Asn His Ala Ile Glu Phe 
        195                 200                 205             


Thr Gly Asp Ser Leu Asn Ala Leu Pro Ile Asp His Arg Leu Thr Ile 
    210                 215                 220                 


Ala Asn Met Thr Thr Glu Trp Gly Ala Leu Ser Gly Leu Phe Pro Val 
225                 230                 235                 240 


Asp Lys Thr Leu Ile Asp Trp Tyr Lys Asn Arg Leu Gln Lys Leu Gly 
                245                 250                 255     


Thr Asn Asn His Pro Arg Ile Asn Pro Lys Thr Ile Arg Ala Leu Glu 
            260                 265                 270         


Glu Lys Ala Lys Ile Pro Lys Ala Asp Lys Asp Ala His Tyr Ala Lys 
        275                 280                 285             


Lys Leu Ile Ile Asp Leu Ala Thr Leu Thr His Tyr Val Ser Gly Pro 
    290                 295                 300                 


Asn Ser Val Lys Val Ser Asn Thr Val Gln Asp Leu Ser Gln Gln Asp 
305                 310                 315                 320 


Ile Lys Ile Asn Lys Ala Tyr Leu Val Ser Cys Thr Asn Ser Arg Leu 
                325                 330                 335     


Ser Asp Leu Gln Ser Ala Ala Asp Val Val Cys Pro Thr Gly Asp Leu 
            340                 345                 350         


Asn Lys Val Asn Lys Val Ala Pro Gly Val Glu Phe Tyr Val Ala Ala 
        355                 360                 365             


Ala Ser Ser Glu Ile Glu Ala Asp Ala Arg Lys Ser Gly Ala Trp Glu 
    370                 375                 380                 


Lys Leu Leu Lys Ala Gly Cys Ile Pro Leu Pro Ser Gly Cys Gly Pro 
385                 390                 395                 400 


Cys Ile Gly Leu Gly Ala Gly Leu Leu Glu Pro Gly Glu Val Gly Ile 
                405                 410                 415     


Ser Ala Thr Asn Arg Asn Phe Lys Gly Arg Met Gly Ser Lys Asp Ala 
            420                 425                 430         


Leu Ala Tyr Leu Ala Ser Pro Ala Val Val Ala Ala Ser Ala Val Leu 
        435                 440                 445             


Gly Lys Ile Ser Ser Pro Ala Glu Val Leu Ser Thr Ser Glu Ile Pro 
    450                 455                 460                 


Phe Ser Gly Val Lys Thr Glu Ile Ile Glu Asn Pro Val Val Glu Glu 
465                 470                 475                 480 


Glu Val Asn Ala Gln Thr Glu Ala Pro Lys Gln Ser Val Glu Ile Leu 
                485                 490                 495     


Glu Gly Phe Pro Arg Glu Phe Ser Gly Glu Leu Val Leu Cys Asp Ala 
            500                 505                 510         


Asp Asn Ile Asn Thr Asp Gly Ile Tyr Pro Gly Lys Tyr Thr Tyr Gln 
        515                 520                 525             


Asp Asp Val Pro Lys Glu Lys Met Ala Gln Val Cys Met Glu Asn Tyr 
    530                 535                 540                 


Asp Ala Glu Phe Arg Thr Lys Val His Pro Gly Asp Ile Val Val Ser 
545                 550                 555                 560 


Gly Phe Asn Phe Gly Thr Gly Ser Ser Arg Glu Gln Ala Ala Thr Ala 
                565                 570                 575     


Leu Leu Ala Lys Gly Ile Asn Leu Val Val Ser Gly Ser Phe Gly Asn 
            580                 585                 590         


Ile Phe Ser Arg Asn Ser Ile Asn Asn Ala Leu Leu Thr Leu Glu Ile 
        595                 600                 605             


Pro Ala Leu Ile Lys Lys Leu Arg Glu Lys Tyr Gln Gly Ala Pro Lys 
    610                 615                 620                 


Glu Leu Thr Arg Arg Thr Gly Trp Phe Leu Lys Trp Asp Val Ala Asp 
625                 630                 635                 640 


Ala Lys Val Val Val Thr Glu Gly Ser Leu Asp Gly Pro Val Ile Leu 
                645                 650                 655     


Glu Gln Lys Val Gly Glu Leu Gly Lys Asn Leu Gln Glu Ile Ile Val 
            660                 665                 670         


Lys Gly Gly Leu Glu Gly Trp Val Lys Ser Gln Leu 
        675                 680                 


<210>  34
<211>  2052
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  34
atgttccact cttcacgcgc gtggctgaaa ggtcaaaacc tgaccgaaaa gatcgtacag       60

tcctacgccg tcaatttgcc ggaaggaaag gtggttcact ctggcgatta cgtttcaatc      120

aaaccagcac actgtatgtc tcacgacaat tcctggccgg tagcgcttaa atttatgggt      180

cttggtgcga ccaagattaa aaacccaagc caaatcgtca ccaccctgga ccatgatatt      240

cagaacaagt ctgagaaaaa tctgaccaag tacaagaaca tcgagaactt tgccaagaag      300

catcacattg atcactaccc cgcgggtcgt ggtatcggcc atcagattat gatcgaagag      360

ggctacgctt ttcccctcaa catgacagtt gcttctgaca gccactcaaa tacgtacggc      420

ggtctcggct cactcggcac tccgattgtg cgcacagacg cagcagctat ttgggctacg      480

ggccagacat ggtggcagat cccaccagtt gcgcaggtgg agctgaaggg ccaacttcct      540

cagggtgtct ccggtaaaga cattatcgtg gcactctgcg gactgttcaa caacgatcaa      600

gtgcttaacc acgcgatcga gtttaccggt gattctctga atgcacttcc gatcgatcac      660

cgcttgacca tcgcgaacat gacgaccgaa tggggtgctc ttagcggcct tttcccggtc      720

gacaagaccc tgatcgattg gtacaaaaat cgcctgcaga aactcggcac aaacaaccac      780

ccccgtatca acccaaagac gatccgcgct cttgaagaaa aggcaaagat ccctaaggcc      840

gataaagatg cccactacgc aaagaaactc attatcgatc tcgcgacact cacgcactac      900

gtatccggcc caaatagcgt taaagtcagc aatactgtcc aggatttgtc ccagcaggat      960

atcaagatca ataaggccta cctggtatca tgtacaaata gccgcctctc ggatctgcaa     1020

tcagcggcag atgttgtgtg cccaacagga gacttgaata aagtcaataa ggtggccccc     1080

ggcgtcgaat tctacgttgc ggcagcatcg tccgaaattg aggctgatgc ccgcaaatca     1140

ggtgcctggg aaaaattgct gaaggcaggc tgtatccccc tgccttctgg ttgtggacct     1200

tgtatcggtc tgggtgcggg cttgcttgag cctggcgaag tgggtatctc cgcgacaaac     1260

cgcaacttca agggacgcat gggctccaag gatgccctgg cataccttgc atctcctgca     1320

gtcgtggctg ccagcgccgt tctgggcaag atttcttcac cagccgaggt cctctcaacc     1380

tctgagatcc ctttctccgg tgttaaaacg gaaatcatcg agaacccggt tgtcgaagag     1440

gaggttaacg cccagaccga agcacctaag caatccgtag aaatcctgga aggctttcca     1500

cgtgagtttt ctggagaatt ggtcctgtgt gatgcagata acatcaacac cgatggcatc     1560

taccccggca agtacacata ccaggatgac gtcccaaaag agaagatggc tcaggtctgc     1620

atggaaaatt acgatgctga attccgcacc aaagttcacc cgggcgacat cgtagtaagc     1680

ggcttcaatt ttggcacggg cagctcccgc gaacaggccg caacagcctt gctggccaag     1740

ggaattaacc tcgttgtatc gggatccttc ggtaatatct tttctcgaaa cagcatcaac     1800

aatgctctgt tgaccctcga gatccccgcg ttgatcaaaa agctgcgcga aaagtatcag     1860

ggagcaccaa aggagctgac ccgtcgtacc ggctggttcc tcaagtggga tgtcgccgat     1920

gccaaagttg tcgtaaccga gggtagcctc gatggcccgg tgattcttga gcaaaaggtt     1980

ggagagctgg gcaaaaacct ccaggaaatc atcgtcaaag gaggactcga aggctgggtt     2040

aagtctcagc tt                                                         2052


<210>  35
<211>  428
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  35

Met Thr Ala Ala Lys Pro Asn Pro Tyr Ala Ala Lys Pro Gly Asp Tyr 
1               5                   10                  15      


Leu Ser Asn Val Asn Asn Phe Gln Leu Ile Asp Ser Thr Leu Arg Glu 
            20                  25                  30          


Gly Glu Gln Phe Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Glu 
        35                  40                  45              


Ile Ala Arg Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr 
    50                  55                  60                  


Ser Pro Val Ala Ser Glu Gln Ser Arg Lys Asp Cys Glu Ala Ile Cys 
65                  70                  75                  80  


Lys Leu Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg Cys His Met 
                85                  90                  95      


Asp Asp Ala Lys Val Ala Val Glu Thr Gly Val Asp Gly Val Asp Val 
            100                 105                 110         


Val Ile Gly Thr Ser Lys Phe Leu Arg Gln Tyr Ser His Gly Lys Asp 
        115                 120                 125             


Met Asn Tyr Ile Ala Lys Ser Ala Val Glu Val Ile Glu Phe Val Lys 
    130                 135                 140                 


Ser Lys Gly Ile Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser 
145                 150                 155                 160 


Asp Leu Val Asp Leu Leu Asn Ile Tyr Lys Thr Val Asp Lys Ile Gly 
                165                 170                 175     


Val Asn Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Asn Pro Arg 
            180                 185                 190         


Gln Val Tyr Glu Leu Ile Arg Thr Leu Lys Ser Val Val Ser Cys Asp 
        195                 200                 205             


Ile Glu Cys His Phe His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala 
    210                 215                 220                 


Tyr Thr Ala Leu Glu Gly Gly Ala Arg Leu Ile Asp Val Ser Val Leu 
225                 230                 235                 240 


Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met Ala 
                245                 250                 255     


Arg Met Ile Val Ala Ala Pro Asp Tyr Val Lys Ser Lys Tyr Lys Leu 
            260                 265                 270         


His Lys Ile Arg Asp Ile Glu Asn Leu Val Ala Asp Ala Val Glu Val 
        275                 280                 285             


Asn Ile Pro Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe Thr His 
    290                 295                 300                 


Lys Ala Gly Ile His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr 
305                 310                 315                 320 


Glu Ile Leu Asp Pro His Asp Phe Gly Met Lys Arg Tyr Ile His Phe 
                325                 330                 335     


Ala Asn Arg Leu Thr Gly Trp Asn Ala Ile Lys Ala Arg Val Asp Gln 
            340                 345                 350         


Leu Asn Leu Asn Leu Thr Asp Asp Gln Ile Lys Glu Val Thr Ala Lys 
        355                 360                 365             


Ile Lys Lys Leu Gly Asp Val Arg Ser Leu Asn Ile Asp Asp Val Asp 
    370                 375                 380                 


Ser Ile Ile Lys Asn Phe His Ala Glu Val Ser Thr Pro Gln Val Leu 
385                 390                 395                 400 


Ser Ala Lys Lys Asn Lys Lys Asn Asp Ser Asp Val Pro Glu Leu Ala 
                405                 410                 415     


Thr Ile Pro Ala Ala Lys Arg Thr Lys Pro Ser Ala 
            420                 425             


<210>  36
<211>  1284
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  36
atgaccgccg cgaaacccaa cccatacgca gcgaagccag gagactacct ttccaacgtt       60

aacaactttc agctcattga ttccaccctg cgcgaaggag aacagttcgc gaatgcgttt      120

ttcgacaccg agaagaagat cgaaatcgct cgtgccttgg atgacttcgg cgtggattac      180

attgaactga cttccccggt ggcctcggag cagagccgca aggactgcga ggcgatctgc      240

aaactgggcc tgaaagccaa gatccttacc catattcgct gccatatgga tgatgctaag      300

gttgcggtag agaccggagt ggacggagtt gacgtcgtga tcggaacgtc gaagtttttg      360

cgccagtact ctcacggcaa ggatatgaat tatatcgcaa agagcgctgt ggaggtaatt      420

gaatttgtga agtcaaaggg cattgaaatt cgcttttcgt ccgaagattc cttccgcagc      480

gaccttgtag accttctgaa tatctataag accgtggaca aaatcggcgt gaatcgagtt      540

ggtatcgccg atacagtggg ttgtgctaat ccccgccaag tctatgaact catccgaacc      600

cttaagagcg tcgtaagctg cgatatcgag tgtcactttc acaacgatac tggctgcgca      660

atcgctaacg catataccgc tctcgaaggc ggcgctcgtc tgattgacgt atcggtcttg      720

ggtatcggcg aacgaaacgg tatcacaccg ctgggcggcc ttatggcacg catgattgtt      780

gcagcaccag actacgttaa gtccaagtac aaacttcaca agatccgaga cattgagaac      840

ctggtcgccg atgccgtcga agtgaatatc ccattcaata atcccattac cggcttctgt      900

gcgttcaccc ataaggcggg catccacgcc aaagccattt tggccaaccc gagcacgtac      960

gagatccttg atccacacga ctttggtatg aagcgttaca tccacttcgc gaatcgtctc     1020

accggctgga acgcaatcaa ggcccgcgta gatcagctca acctcaacct taccgatgat     1080

caaatcaaag aagtcaccgc caaaatcaag aagctcggtg acgttcgctc gcttaacatc     1140

gatgacgttg attcaattat caagaacttc catgcggaag tgtcaactcc ccaagtactc     1200

tccgctaaga agaataagaa gaatgactca gacgtgccag aacttgcgac cattcctgcc     1260

gccaaacgta ctaaaccatc cgcg                                            1284


<210>  37
<211>  487
<212>  PRT
<213>  Stemphylium lycopersici

<400>  37

Met Cys Pro Pro Thr Glu Glu Thr Pro Ala Thr Asn Gly His Ser Asn 
1               5                   10                  15      


Gly Thr Asn Gly Ala Pro Ile Asn Lys Glu Gly Phe Thr Gly Val Gln 
            20                  25                  30          


Thr Lys Gln Asn Pro His Pro Thr His Lys Ser Pro Tyr Gln Pro Val 
        35                  40                  45              


Gly Asp Phe Leu Ser Asn Val Gly Arg Phe Lys Ile Ile Glu Ser Thr 
    50                  55                  60                  


Leu Arg Glu Gly Glu Gln Phe Ala Asn Ala Tyr Phe Asp Leu Glu Ala 
65                  70                  75                  80  


Lys Ile Lys Ile Ala Arg Ala Leu Asp Asn Phe Gly Val Asp Tyr Ile 
                85                  90                  95      


Glu Val Thr Ser Pro Ala Ala Ser Glu Gln Ser Arg Arg Asp Cys Glu 
            100                 105                 110         


Ala Leu Cys Lys Leu Gly Leu Lys Ala Lys Ile Leu Thr His Val Arg 
        115                 120                 125             


Cys His Met Asp Asp Ala Arg Ile Ala Val Glu Thr Gly Val Asp Gly 
    130                 135                 140                 


Leu Asp Val Val Ile Gly Thr Ser Ala Tyr Leu Arg Glu His Ser His 
145                 150                 155                 160 


Gly Lys Asp Met Thr Tyr Ile Lys Asn Thr Ala Leu Glu Val Ile Glu 
                165                 170                 175     


Phe Val Lys Ser Lys Gly Lys Glu Ile Arg Phe Ser Ser Glu Asp Ser 
            180                 185                 190         


Phe Arg Ser Asp Leu Val Asp Leu Leu Ser Ile Tyr Ser Ala Val Asp 
        195                 200                 205             


Lys Val Gly Val Asp Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala 
    210                 215                 220                 


Ser Pro Arg Gln Val Tyr Asp Leu Val Arg Thr Leu Arg Gly Val Val 
225                 230                 235                 240 


Ser Cys Asp Ile Glu Thr His Phe His Asn Asp Ser Gly Cys Ala Ile 
                245                 250                 255     


Ala Asn Ala Phe Cys Ala Leu Glu Ala Gly Ala Thr His Ile Asp Thr 
            260                 265                 270         


Ser Val Leu Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly 
        275                 280                 285             


Leu Met Ala Arg Met Ile Val Ala Asp Arg Glu Tyr Val Thr Ser Lys 
    290                 295                 300                 


Tyr Asn Ile Lys Ala Leu Lys Glu Val Glu Asp Leu Val Ala Asp Leu 
305                 310                 315                 320 


Val Glu Val Asn Ile Pro Phe Asn Asn Tyr Ile Thr Gly Phe Cys Ala 
                325                 330                 335     


Phe Thr His Lys Ala Gly Ile His Ala Lys Ala Ile Leu Asn Asn Pro 
            340                 345                 350         


Ser Thr Tyr Glu Ile Ile Asn Pro Gln Asp Phe Gly Met Ser Arg Tyr 
        355                 360                 365             


Val His Phe Ala Ser Arg Leu Thr Gly Trp Asn Ala Ile Lys Ser Arg 
    370                 375                 380                 


Ala Glu Gln Leu Gly Leu Lys Met Thr Asp Ala Gln Tyr Lys Glu Cys 
385                 390                 395                 400 


Thr Ala Lys Ile Lys Ala Ile Ala Asp Ile Arg Lys Ile Ala Leu Asp 
                405                 410                 415     


Asp Thr Asp Ser Ile Ile Arg Thr Tyr His Asn Asn Leu His Ala Thr 
            420                 425                 430         


Glu Glu Val Pro Leu Leu Pro Gly Met Thr Glu Glu Glu Lys Ala Lys 
        435                 440                 445             


Phe Ala Gln Ala Glu Ala Glu Leu Asn Gly Met His Glu Lys Arg Glu 
    450                 455                 460                 


Leu Asp Ala Thr Ala Asp Ala Gln Ala Glu Val Pro Val Ala Lys Lys 
465                 470                 475                 480 


Asn Lys Thr Ala Thr Val Ala 
                485         


<210>  38
<211>  1461
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  38
atgtgcccac ccacggagga gaccccggca accaacggtc actcaaacgg tacaaacggt       60

gccccaatta acaaagaagg atttaccggc gtgcaaacga agcaaaatcc ccacccgacg      120

cataagtccc cctatcaacc cgtcggagat tttctgagca acgttggtcg tttcaagatc      180

attgagtcaa cccttcgcga aggtgagcag tttgcaaacg catactttga tctggaggcg      240

aagattaaaa ttgctcgtgc actcgataac tttggcgttg actatatcga ggtaacctct      300

ccagccgcat cggagcaatc ccgccgcgat tgcgaggcgc tctgcaaact gggtcttaag      360

gcaaaaatcc tcacccacgt ccgttgccat atggacgatg cgcgtatcgc tgtcgagacg      420

ggcgtggatg gactggacgt tgtgatcggt acttcagcct acctgcgcga acattctcac      480

ggaaaggata tgacgtacat caagaacacc gctctcgagg tgattgagtt cgtaaaaagc      540

aaaggaaagg agattcgctt ttcctcggaa gattccttcc gcagcgatct ggttgacctt      600

ctctccatct actctgcagt tgataaagtg ggtgtcgatc gagtgggtat tgcggatacc      660

gtaggctgtg cctccccccg tcaggtctac gacctggtcc gaaccctgcg cggagttgtg      720

tcctgcgaca tcgaaactca tttccacaac gactcgggct gcgcaatcgc gaatgccttc      780

tgcgcactcg aagccggcgc cacccatatt gatacttctg tcctgggtat cggtgaacgc      840

aatggtatta ctccactggg aggactcatg gcacgcatga tcgttgccga ccgcgaatat      900

gttacatcca agtacaacat caaggccctg aaagaggttg aggacctcgt cgcagacctg      960

gtcgaggtca acatcccctt caacaactac attaccggtt tctgtgcatt tactcataag     1020

gccggcatcc atgcaaaagc catcctgaac aacccgtcca cgtacgagat cattaaccca     1080

caggattttg gtatgtcccg ctacgttcac ttcgcctcac gactcacagg ttggaacgcg     1140

atcaagtccc gcgcagaaca actcggattg aagatgactg atgcccagta caaagagtgc     1200

accgcaaaaa tcaaagccat tgcagatatc cgtaaaatcg cactggacga caccgactcg     1260

attatccgta cctaccacaa caacctgcac gccacagaag aggtgccatt gcttcctggc     1320

atgactgagg aggaaaaggc caagtttgcc caggctgaag ccgagcttaa cggcatgcat     1380

gaaaagcgcg aacttgatgc cactgcagac gcacaggccg aagttccggt cgcgaagaag     1440

aacaaaaccg cgacagtggc t                                               1461


<210>  39
<211>  359
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  39

Met Gly Leu Ala Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu 
1               5                   10                  15      


Ile Pro Gly Asp Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln 
            20                  25                  30          


Val Leu Glu Asn Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile 
        35                  40                  45              


Asp Leu Tyr Ala Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu 
    50                  55                  60                  


Pro Asp Glu Thr Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu 
65                  70                  75                  80  


Phe Gly Ala Val Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser 
                85                  90                  95      


Pro Ile Val Ala Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg 
            100                 105                 110         


Pro Val Lys Ser Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val 
        115                 120                 125             


Ile Val Arg Glu Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr 
    130                 135                 140                 


Tyr Ile Asp Lys Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg 
145                 150                 155                 160 


Ile Ser Glu Ile Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile 
                165                 170                 175     


Ala Leu Lys Arg Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr 
            180                 185                 190         


His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile 
        195                 200                 205             


Cys Lys Glu Val Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys 
    210                 215                 220                 


Tyr Asn Glu Gln Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu 
225                 230                 235                 240 


Pro Gln Cys Phe Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile 
                245                 250                 255     


Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro 
            260                 265                 270         


Ser Ala Asn Val Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly 
        275                 280                 285             


Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr 
    290                 295                 300                 


Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala 
305                 310                 315                 320 


Ala Gln Asp Ile Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser 
                325                 330                 335     


Ile Lys Thr Pro Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val 
            340                 345                 350         


Asp Asp Val Leu Ser Arg Leu 
        355                 


<210>  40
<211>  1077
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  40
atgggtctcg ccagcaacgc ggcccgcaaa tccctgacca tcggcctgat cccaggtgat       60

ggcattggca aagaagttat ccccgccggc aagcaagtgt tggagaacct taattccaaa      120

cacggcttgt cttttaattt cattgacttg tacgcgggct ttcagacctt ccaggaaacc      180

ggtaaagctc tgcccgatga gaccgtcaaa gtgctgaaag aacaatgtca aggcgccctt      240

tttggagccg tccaatcccc gaccactaag gttgagggtt acagcagccc aatcgttgcc      300

ttgcgtcgtg aaatgggact gttcgcgaac gtccgccctg tcaagtccgt ggagggcgaa      360

aagggaaagc ctattgacat ggttatcgtg cgtgaaaaca ctgaagatct ctacatcaaa      420

attgagaaga catacattga taaggccacc ggcacacgcg tagcggatgc gaccaagcgt      480

atctctgaaa tcgcaacgcg ccgcatcgcc accatcgcac tcgatattgc gctgaaacgt      540

ctgcaaactc gaggacaggc caccctgacc gtcacgcaca agtctaacgt tctgtcccag      600

agcgatggac tgtttcgcga gatttgtaag gaagtttacg aatccaataa ggataagtac      660

ggacagatca aatataatga acaaattgtg gactccatgg tgtaccgctt gttccgcgaa      720

ccacagtgtt tcgacgttat cgttgctccg aatctgtacg gagatatcct ctctgacggt      780

gcagcggcgt tggttggatc gctgggcgtg gtacctagcg caaacgttgg tccagaaatt      840

gtgatcggcg agccatgtca cggctcggct ccagatatcg caggaaaggg catcgcaaat      900

cccatcgcca ccatccgctc cactgctctg atgctggagt tcttgggtca caatgaagcg      960

gcgcaagaca tctacaaggc cgtggatgca aaccttcgtg aaggctccat caagactcca     1020

gatcttggag gaaaagcgtc gacacaacag gtcgtcgatg atgtactttc acgcctg        1077


<210>  41
<211>  1254
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  41
atgtccgtgt ccgaagcgaa cggaaccgaa acgattaaac ccccgatgaa tggcaacccc       60

tatggtccaa acccctccga ctttttgtct cgtgttaata acttctccat catcgaatct      120

accttgcgtg agggcgaaca attcgcaaat gcttttttcg acaccgaaaa gaagattcag      180

atcgctaagg ccctggataa cttcggtgtc gattacatcg agttgacatc tccagtggct      240

tcagaacagt cccgtcaaga ttgcgaggct atctgtaagt tgggtctgaa atgtaaaatt      300

ttgacccaca tccgatgtca catggacgac gctcgcgtgg cagtggaaac tggtgtcgac      360

ggtgttaacg tggtgattgg cacctcccag tacctgcgca agtacagcca cggtaaggac      420

atgacctaca tcattgactc cgctaccgaa gttatcaact ttgtgaaatc aaagggcatt      480

gaagtgcgct tctcatcaga ggattcgttc cgttctgatt tggtggatct tcttagcctc      540

tacaaagctg tggataagat cggtgttaac cgcgttggca tcgcagatac ggtgggttgc      600

gccactcctc gccaagtata cgaccttatc cgcacacttc gtggcgttgt gtcctgcgat      660

attgaatgcc atttccacaa cgacactggt atggccattg caaatgcata ctgcgcgttg      720

gaggccggtg ctactcacat tgacacatcc attctgggta ttggcgaacg aaatggaatt      780

accccactgg gtgccctcct ggctcgtatg tacgtaacgg accgagaata tattacccac      840

aaatacaagc tgaaccagct gcgcgaattg gaaaatcttg ttgcggatgc tgttgaagtt      900

cagattccat tcaataacta cattacgggc atgtgcgctt ttacccacaa ggcaggaatc      960

cacgcgaagg caatccttgc taacccaagc acgtacgaga tccttaaacc cgaagatttc     1020

ggcatgtccc gatacgtaca tgttggatcc cgtctgaccg gttggaacgc tatcaaatca     1080

cgcgctgaac agctcaacct ccatctgaca gatgctcagg caaaggaact cactgtacgc     1140

atcaagaagc tcgcggacgt ccgaaccctg gccatggatg atgtcgaccg cgtccttcgt     1200

gaatatcatg cggacctcag cgatgcagac cgcattacta aagaagcatc cgcg           1254


<210>  42
<211>  380
<212>  PRT
<213>  Paenibacillus riograndensis

<400>  42

Met Lys Ser Leu Lys Leu Cys Asp Thr Thr Leu Arg Asp Gly Glu Gln 
1               5                   10                  15      


Ala Ala Gly Val Ser Phe Thr Arg Thr Glu Lys Leu Glu Ile Ala Lys 
            20                  25                  30          


Leu Leu Ser Glu Cys Gly Val Glu Gln Ala Glu Val Gly Ile Pro Ala 
        35                  40                  45              


Met Gly Thr Arg Glu Gln Glu Asp Ile Ala Ala Ile Ala Glu Leu Asn 
    50                  55                  60                  


Leu Pro Met Lys Leu Met Thr Trp Asn Arg Ser Leu Pro Gly Asp Ile 
65                  70                  75                  80  


Asp Lys Ala Arg Ala Thr Gly Val Asn Trp Ser His Val Ser Ile Pro 
                85                  90                  95      


Val Ser Glu Ile Gln Leu Gln Gly Lys Leu Gly Leu Ser Thr Asp Glu 
            100                 105                 110         


Gly Leu Asn Lys Leu Leu Gly Ala Ala Glu Tyr Ala Leu Ser Leu Gly 
        115                 120                 125             


Met Thr Val Ser Val Gly Met Glu Asp Ser Ser Arg Ala Asp Met Gly 
    130                 135                 140                 


Phe Leu Ile Arg Leu Val Asn Ser Leu His Arg Glu Gly Ile Cys Arg 
145                 150                 155                 160 


Phe Arg Tyr Ala Asp Thr Val Ser Ala His His Pro Gly Gln Ile Ala 
                165                 170                 175     


Glu Arg Val Ser Thr Leu Leu Gly Glu Val Pro Gly Asp Val Glu Leu 
            180                 185                 190         


Glu Val His Cys His Asn Asp Phe Gly Leu Ala Cys Ala Asn Thr Leu 
        195                 200                 205             


Ser Gly Ile Ala Ala Gly Ala Ala Trp Ala Ser Thr Thr Val Ala Gly 
    210                 215                 220                 


Ile Gly Glu Arg Thr Gly Asn Ala Ala Met Glu Glu Val Val Met Ala 
225                 230                 235                 240 


Trp His His Leu Tyr Gly Gly Asp Ser Ser Val Arg Phe Asp Leu Leu 
                245                 250                 255     


Lys Gly Leu Ala Asp Lys Val Ile Ala Ala Ser Gly Arg Ser Val Gly 
            260                 265                 270         


Asp Ala Lys Pro Ile Val Gly Gln Leu Ala Phe Thr His Glu Ser Gly 
        275                 280                 285             


Ile His Val Asp Gly Leu Met Lys Glu Arg Ala Thr Tyr Gln Thr Phe 
    290                 295                 300                 


Asp Pro Ser Glu Val Gly Arg Ser His Arg Phe Val Leu Gly Lys His 
305                 310                 315                 320 


Ser Gly Thr Gly Gly Val Ala His Val Leu Glu Gln Leu Gly Leu Ala 
                325                 330                 335     


Ile Thr Pro Asp Thr Ala Gly Arg Leu Leu Val Arg Val Arg Glu Tyr 
            340                 345                 350         


Ala Glu Ser His Lys Gly Thr Val Pro Glu Tyr Met Leu Val Gln Trp 
        355                 360                 365             


Leu Met Glu Glu Gln Gln Arg Ala Gln Asn Val Val 
    370                 375                 380 


<210>  43
<211>  1140
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  43
atgaagtccc tgaaactttg cgataccacc ctccgcgatg gagaacaggc agcgggtgtt       60

tcgtttacac gcactgagaa actcgaaatc gctaaactgc tctctgagtg tggagtagaa      120

caggcggagg ttggtatccc tgccatgggt acgcgcgagc aagaggatat tgctgcaatc      180

gccgaactca acttgccaat gaagttgatg acctggaatc gttcgctccc tggcgacatt      240

gacaaggcac gcgcaaccgg tgtcaattgg tcccatgtct cgatccccgt ctccgagatt      300

cagttgcagg gtaagctcgg cttgtccaca gatgaaggcc ttaacaagtt gctcggcgcg      360

gcggaatacg ccctgtcttt gggcatgacc gtatcggtcg gtatggagga ttcctcgcgc      420

gctgatatgg gcttcctcat ccgcctcgtc aattcactgc atcgtgaggg tatctgccgc      480

ttccgatacg ccgatactgt atctgcgcac catccaggac agatcgcgga acgcgtgtcg      540

acccttttgg gagaagttcc gggcgacgtt gaacttgaag tgcactgcca taacgacttc      600

ggtctggcct gtgcgaatac cctgtcggga atcgccgcag gcgctgcctg ggcatccaca      660

accgtggcgg gcattggtga gcgcaccggt aacgcggcaa tggaagaagt ggtgatggct      720

tggcaccatc tgtacggtgg cgattcctcg gtgcgcttcg acttgctgaa gggcctggca      780

gacaaggtta tcgctgcttc tggtcgttcc gtgggtgatg caaaacccat tgtcggtcag      840

ctggcattca cacacgaatc cggtattcat gtcgatggcc tcatgaagga gcgcgcaacc      900

taccaaacgt ttgatccttc agaggtaggc cgttctcacc gcttcgtcct cggtaagcat      960

tccggaaccg gcggagtcgc gcacgtactc gagcaactcg gactcgctat caccccagac     1020

accgccggcc gcttgctggt tcgcgttcga gagtacgcag aaagccacaa aggtaccgtt     1080

ccggagtata tgttggtcca gtggctcatg gaagaacagc agcgtgcgca gaacgtcgtt     1140


<210>  44
<211>  673
<212>  PRT
<213>  Neosartorya fumigata

<400>  44

Met Arg Tyr Thr Glu Ala Ser Ser Ser Thr Thr Gln Thr Ser Pro Ser 
1               5                   10                  15      


Ser Ser Ser Trp Pro Ala Pro Asp Ala Ala Pro Arg Val Pro Gln Thr 
            20                  25                  30          


Leu Thr Glu Lys Ile Val Gln Ala Tyr Ser Leu Gly Leu Ala Glu Gly 
        35                  40                  45              


Gln Tyr Val Lys Ala Gly Asp Tyr Val Met Leu Ser Pro His Arg Cys 
    50                  55                  60                  


Met Thr His Asp Asn Ser Trp Pro Thr Ala Leu Lys Phe Met Ala Ile 
65                  70                  75                  80  


Gly Ala Ser Lys Val His Asn Pro Asp Gln Ile Val Met Thr Leu Asp 
                85                  90                  95      


His Asp Val Gln Asn Lys Ser Glu Lys Asn Leu Lys Lys Tyr Glu Ser 
            100                 105                 110         


Ile Glu Lys Phe Ala Lys Gln His Gly Ile Asp Phe Tyr Pro Ala Gly 
        115                 120                 125             


His Gly Val Gly His Gln Ile Met Ile Glu Glu Gly Tyr Ala Phe Pro 
    130                 135                 140                 


Gly Thr Val Thr Val Ala Ser Asp Ser His Ser Asn Met Tyr Gly Gly 
145                 150                 155                 160 


Val Gly Cys Leu Gly Thr Pro Met Val Arg Thr Asp Ala Ala Thr Ile 
                165                 170                 175     


Trp Ala Thr Gly Arg Thr Trp Trp Lys Val Pro Pro Ile Ala Lys Val 
            180                 185                 190         


Gln Phe Thr Gly Thr Leu Pro Glu Gly Val Thr Gly Lys Asp Val Ile 
        195                 200                 205             


Val Ala Leu Ser Gly Leu Phe Asn Lys Asp Glu Val Leu Asn Tyr Ala 
    210                 215                 220                 


Ile Glu Phe Thr Gly Ser Glu Glu Thr Met Lys Ser Leu Ser Val Asp 
225                 230                 235                 240 


Thr Arg Leu Thr Ile Ala Asn Met Thr Thr Glu Trp Gly Ala Leu Thr 
                245                 250                 255     


Gly Leu Phe Pro Ile Asp Ser Thr Leu Glu Gln Trp Leu Arg His Lys 
            260                 265                 270         


Ala Ala Thr Ala Ser Arg Thr Glu Thr Ala Arg Arg Phe Ala Glu Glu 
        275                 280                 285             


Arg Ile Asn Glu Leu Phe Ala Asn Pro Thr Val Ala Asp Arg Gly Ala 
    290                 295                 300                 


Arg Tyr Ala Lys Tyr Leu Tyr Leu Asp Leu Ser Thr Leu Ser Pro Tyr 
305                 310                 315                 320 


Val Ser Gly Pro Asn Ser Val Lys Val Ala Thr Pro Leu Asp Glu Leu 
                325                 330                 335     


Glu Lys His Lys Leu Lys Ile Asp Lys Ala Tyr Leu Val Ser Cys Thr 
            340                 345                 350         


Asn Ser Arg Ala Ser Asp Ile Ala Ala Ala Ala Lys Val Phe Lys Asp 
        355                 360                 365             


Ala Val Ala Arg Thr Gly Gly Pro Val Arg Val Ala Asp Gly Val Glu 
    370                 375                 380                 


Phe Tyr Val Ala Ala Ala Ser Lys Ala Glu Gln Lys Ile Ala Glu Glu 
385                 390                 395                 400 


Ala Gly Asp Trp Gln Ala Leu Met Asp Ala Gly Ala Ile Pro Leu Pro 
                405                 410                 415     


Ala Gly Cys Ala Val Cys Ile Gly Leu Gly Ala Gly Leu Leu Lys Glu 
            420                 425                 430         


Gly Glu Val Gly Ile Ser Ala Ser Asn Arg Asn Phe Lys Gly Arg Met 
        435                 440                 445             


Gly Ser Pro Asp Ala Lys Ala Tyr Leu Ala Ser Pro Glu Val Val Ala 
    450                 455                 460                 


Ala Ser Ala Leu Asn Gly Val Ile Ser Gly Pro Gly Ile Tyr Lys Arg 
465                 470                 475                 480 


Pro Glu Asp Trp Thr Gly Val Ser Ile Gly Glu Gly Glu Val Val Glu 
                485                 490                 495     


Ser Gly Ser Arg Ile Asp Thr Thr Leu Glu Ala Met Glu Lys Phe Ile 
            500                 505                 510         


Gly Gln Leu Asp Ser Met Ile Asp Ser Ser Ser Lys Ala Val Met Pro 
        515                 520                 525             


Glu Glu Ser Thr Gly Ser Gly Ala Thr Glu Val Asp Ile Val Pro Gly 
    530                 535                 540                 


Phe Pro Glu Lys Ile Glu Gly Glu Ile Leu Phe Leu Asp Ala Asp Asn 
545                 550                 555                 560 


Ile Ser Thr Asp Gly Ile Tyr Pro Gly Lys Tyr Thr Tyr Gln Asp Asp 
                565                 570                 575     


Val Thr Lys Asp Lys Met Ala Gln Val Cys Met Glu Asn Tyr Asp Pro 
            580                 585                 590         


Ala Phe Ser Gly Ile Ala Arg Ala Gly Asp Ile Phe Val Ser Gly Phe 
        595                 600                 605             


Asn Phe Gly Cys Gly Ser Ser Arg Glu Gln Ala Ala Thr Ser Ile Leu 
    610                 615                 620                 


Ala Lys Gln Leu Pro Leu Val Val Ala Gly Ser Ile Gly Asn Thr Phe 
625                 630                 635                 640 


Ser Arg Asn Ala Val Asn Asn Ala Leu Pro Leu Leu Glu Met Pro Arg 
                645                 650                 655     


Leu Ile Glu Arg Leu Arg Glu Ala Phe Gly Ser Glu Lys Gln Pro Thr 
            660                 665                 670         


Arg 
    


<210>  45
<211>  2019
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  45
atgcgctata ccgaagcttc cagctcgaca acacaaacct cccctagctc ttcctcgtgg       60

cccgccccgg acgctgcgcc acgcgtgcct cagacgctca ctgaaaaaat tgtgcaagcg      120

tattcactcg gcctggcgga aggtcagtac gtcaaggcgg gagattacgt gatgctctct      180

ccccaccgct gcatgaccca cgacaattcg tggcccaccg cattgaaatt tatggcgatc      240

ggcgcatcga aagttcataa ccctgatcaa atcgtgatga ccttggacca cgacgtccag      300

aataaatccg aaaagaacct gaaaaaatac gaatcgatcg agaagtttgc caagcagcac      360

ggtatcgatt tctacccggc cggccacgga gtgggccatc aaattatgat tgaggaagga      420

tacgctttcc caggaaccgt gaccgtcgca tctgattcac acagcaacat gtacggtggc      480

gtgggctgcc ttggaactcc aatggtacga actgatgcag caaccatctg ggcaaccggc      540

cgcacgtggt ggaaggtgcc acctatcgca aaagtgcagt ttacaggtac tcttccggaa      600

ggcgtcacag gcaaagatgt gattgttgca ctgtcgggat tgtttaacaa agacgaagtg      660

ttgaattacg caatcgagtt cacgggaagc gaagaaacaa tgaaatctct ctcggtcgat      720

acacgcctga ccatcgctaa tatgaccacg gagtggggtg cgttgaccgg tctgttccct      780

atcgattcca cgctggagca gtggcttcga cacaaggcag caaccgcgtc ccgaaccgaa      840

actgcccgcc gcttcgcgga ggaacgcatt aacgagctct ttgccaaccc aactgtggct      900

gatcgaggcg cacgctacgc gaaatacctt tatctggatt tgtctaccct gtccccttac      960

gtttctggtc caaacagcgt caaggttgcc acaccactgg atgaactgga aaagcacaag     1020

ttgaagatcg ataaggccta cttggtctct tgcaccaact cccgagcaag cgatatcgct     1080

gcagcagcta aggtttttaa ggatgcggtt gcacgtactg gcggccctgt ccgtgttgca     1140

gatggcgttg agttttatgt cgctgcggca tccaaagcag aacaaaagat cgcggaagaa     1200

gctggagatt ggcaagctct tatggacgcc ggagcaattc ctcttccggc aggttgcgcc     1260

gtatgcattg gcctcggcgc gggcctcctc aaggaaggag aggtcggcat ttcggcctcc     1320

aaccgtaact ttaagggccg catgggttcc ccagacgcaa aggcatacct tgcatctcca     1380

gaagtggttg ctgcgagcgc gctgaatggt gttatttcgg gacctggtat ttataaacgc     1440

cctgaggatt ggaccggtgt ctccatcggt gaaggtgaag ttgtggaatc cggctcgcgc     1500

attgacacaa ctctggaagc catggagaag tttatcggac aacttgattc catgatcgac     1560

tcctcctcta aggctgtaat gccagaagaa agcactggtt ccggtgcaac ggaggtggac     1620

atcgtcccgg gttttccgga aaagattgaa ggtgaaatct tgttcctgga tgcggacaac     1680

attagcactg acggcattta cccgggtaag tacacttacc aagatgacgt gaccaaggat     1740

aaaatggctc aagtgtgtat ggagaactac gacccagcgt tctcgggaat cgcgcgcgca     1800

ggcgacatct tcgtgtcagg cttcaatttc ggatgcggtt cttcccgcga acaggcagca     1860

acctccattc tggcaaaaca attgcctctg gtggttgcag gctcgatcgg caacaccttt     1920

tcccgaaatg ctgtcaataa tgccctgccc ttgctggaaa tgccacgtct tatcgaacgc     1980

ctccgtgaag cctttggctc tgagaaacag ccaacccgc                            2019


<210>  46
<211>  376
<212>  PRT
<213>  Chloroflexi bacterium

<400>  46

Met Pro Val Glu Arg Phe Ala Ile Ile Asp Ser Thr Leu Arg Glu Gly 
1               5                   10                  15      


Glu Gln Phe Ser Ser Ala His Phe Thr Thr Asp Gln Lys Val Val Val 
            20                  25                  30          


Ala Lys Ala Leu Asp Ala Phe Gly Val Glu Tyr Ile Glu Val Thr Ser 
        35                  40                  45              


Pro Val Ala Ser Pro Gln Ser Phe Asp Asp Cys Lys Thr Ile Ala Ala 
    50                  55                  60                  


Leu Pro Leu Lys Ala Lys Val Leu Thr His Val Arg Cys His Met Asp 
65                  70                  75                  80  


Asp Ala Arg Val Ala Val Glu Thr Cys Val Asp Gly Ile Asp Ile Leu 
                85                  90                  95      


Phe Gly Thr Ser Ser Phe Leu Arg Glu Phe Ser His Gly Lys Ser Val 
            100                 105                 110         


Asp Glu Ile Ile Ala Gln Ala Gly Glu Val Ile Thr Phe Ile Lys Asp 
        115                 120                 125             


His Gly Lys Glu Val Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Thr 
    130                 135                 140                 


Glu Gly Asp Leu Leu Arg Val Tyr Gln Ala Val Asp Ser Met Gly Val 
145                 150                 155                 160 


Asp Arg Val Gly Ile Ala Asp Thr Val Gly Ile Ala Thr Pro Arg Gln 
                165                 170                 175     


Cys Tyr Ala Leu Ala His Glu Leu Arg Arg Asn Val Ser Cys Asp Ile 
            180                 185                 190         


Glu Phe His Gly His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ser Tyr 
        195                 200                 205             


Ser Val Leu Glu Gly Gly Ala Thr His Ile Asp Thr Ser Ile Leu Gly 
    210                 215                 220                 


Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Phe Ile Ala Arg 
225                 230                 235                 240 


Met Tyr Ala Asp Asp Pro Ala Ala Ile Lys Arg Lys Tyr Asp Leu Pro 
                245                 250                 255     


Arg Leu Arg Glu Leu Asp Glu Leu Val Ala Ser Met Val Gly Ile Asp 
            260                 265                 270         


Val Pro Phe Asp Glu Tyr Val Thr Gly Lys Phe Ala Phe His His Lys 
        275                 280                 285             


Ala Gly Met His Thr Lys Ala Ile Tyr Leu Asn Pro Asn Ser Tyr Glu 
    290                 295                 300                 


Ile Leu Asp Pro Ala Asp Phe Gly Leu Glu Arg Thr Ile Asn Ile Ala 
305                 310                 315                 320 


His Arg Leu Thr Gly Tyr Asn Ala Val Gly Arg Arg Ala Gln Glu Leu 
                325                 330                 335     


Gly Leu Gln Phe Gly Lys Asp Asp Leu Arg Glu Val Thr Lys Arg Ile 
            340                 345                 350         


Lys Ala Met Ala Asp Ala Gly Pro Leu Ser Met Asp Gln Leu Asp Gln 
        355                 360                 365             


Ile Leu Arg Gly Tyr Val Val Ala 
    370                 375     


<210>  47
<211>  1128
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  47
atgccggtgg agcgttttgc aatcatcgat tcgaccttgc gcgagggtga gcaattttcc       60

tccgctcact tcacgaccga tcagaaagtg gtggtggcta aggctctcga cgcttttggt      120

gttgagtaca ttgaagtcac ttctcctgtc gcctccccac agtcattcga tgactgtaag      180

actattgcgg cactcccctt gaaagcaaaa gtgttgactc acgttcgttg tcatatggat      240

gatgctcgcg tggcggtgga gacgtgcgtt gacggcattg atatcctctt tggcactagc      300

tcttttctgc gagaattttc tcacggcaag tccgtggatg agatcattgc ccaggcggga      360

gaagttatta cattcatcaa ggatcacgga aaggaagttc gtttttcgtc cgaagactcc      420

ttccgctcaa cagaaggaga cctgctgcgc gtgtatcagg ccgttgacag catgggtgtc      480

gatcgcgtgg gtattgctga cacggtggga attgctacac cccgtcaatg ttacgctctc      540

gcccatgagc ttcgccgaaa cgtgtcgtgt gacatcgaat tccatggtca taacgatacc      600

ggctgcgcca tcgcaaattc gtactcggtc ctggagggcg gcgctactca catcgacacg      660

agcattctgg gtatcggcga gcgcaacggc attacaccac tgggaggatt catcgctcgt      720

atgtacgcgg acgacccagc ggctatcaaa cgcaaatatg atcttcctcg ccttcgagag      780

ttggatgaac tggttgcttc catggtcggt attgacgtgc ctttcgacga atacgtcacc      840

ggtaagtttg cgttccacca caaggcaggt atgcacacta aggcgattta cctcaatcca      900

aactcctacg aaatccttga cccagcggat tttggtctcg agcgtaccat taacatcgcc      960

caccgcctca cgggctacaa cgcggtggga cgacgcgccc aggaactggg tctccaattc     1020

ggtaaggacg acctccgaga agtgaccaaa cgaatcaagg ccatggcaga tgctggacca     1080

ctgtcaatgg atcaattgga ccaaatcttg cgcggctacg tggtggca                  1128


<210>  48
<211>  442
<212>  PRT
<213>  Ashbya gossypii

<400>  48

Met Ser Gln Gly Asn Glu Phe His Gln Val Thr Glu Ala Thr Thr Ala 
1               5                   10                  15      


Leu Asn Asn Phe Gln Gln Asn Pro Tyr Gly Pro Asn Pro Ala Asp Tyr 
            20                  25                  30          


Leu Ser Asn Val Gly Ser Phe Gln Leu Ile Asp Ser Thr Leu Arg Glu 
        35                  40                  45              


Gly Glu Gln Phe Ala Asn Ala Phe Phe Ser Thr Glu Lys Lys Ile Glu 
    50                  55                  60                  


Ile Ala Arg Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr 
65                  70                  75                  80  


Ser Pro Val Ala Ser Glu Gln Ser Leu Arg Asp Cys Gln Ala Ile Cys 
                85                  90                  95      


Lys Leu Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg Cys His Met 
            100                 105                 110         


Asp Asp Ala Lys Val Ala Val Gly Thr Gly Val Asp Gly Val Asp Val 
        115                 120                 125             


Val Ile Gly Thr Ser Lys Phe Leu Arg Gln Tyr Ser His Gly Lys Asp 
    130                 135                 140                 


Met Asn Tyr Ile Ala Lys Ser Ala Ile Glu Val Ile Glu Tyr Val Lys 
145                 150                 155                 160 


Ser Lys Gly Ile Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser 
                165                 170                 175     


Asp Leu Val Asp Leu Leu Asn Ile Tyr Lys Thr Val Asp Lys Ile Gly 
            180                 185                 190         


Val Asn Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Asn Pro Arg 
        195                 200                 205             


Gln Val Tyr Glu Leu Val Arg Thr Leu Lys Ser Val Val Ser Cys Asp 
    210                 215                 220                 


Val Glu Cys His Phe His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala 
225                 230                 235                 240 


Tyr Thr Ala Leu Glu Gly Gly Ala Lys Leu Val Asp Val Ser Val Leu 
                245                 250                 255     


Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met Ala 
            260                 265                 270         


Arg Met Ile Val Ala Ala Pro Asp Tyr Val Lys Ser Lys Tyr Lys Leu 
        275                 280                 285             


His Lys Ile Arg Asp Ile Glu Asn Leu Val Ala Glu Ala Val Glu Val 
    290                 295                 300                 


Asn Val Pro Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe Thr His 
305                 310                 315                 320 


Lys Ala Gly Ile His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr 
                325                 330                 335     


Glu Ile Leu Asn Pro Asn Asp Phe Gly Met Thr Arg Tyr Ile His Phe 
            340                 345                 350         


Ala Asn Arg Leu Thr Gly Trp Asn Ala Ile Lys Ser Arg Val Asp Gln 
        355                 360                 365             


Leu Asn Leu His Leu Thr Asp Asp Gln Val Lys Glu Val Thr Ala Lys 
    370                 375                 380                 


Ile Lys Gln Leu Gly Asp Val Arg Pro Leu Asn Ile Asp Asp Val Asp 
385                 390                 395                 400 


Ser Ile Ile Lys Ala Phe His Ala Gln Ile Ala Thr Pro Arg Val Thr 
                405                 410                 415     


Ala Arg Pro Ala Asn Arg Glu Glu Glu Ile Asn Gly Phe Asp Leu Glu 
            420                 425                 430         


Ala Pro Pro Gln Lys Lys Thr Lys Ile Leu 
        435                 440         


<210>  49
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  49
atgtcccaag gtaacgaatt tcaccaagtt accgaggcaa cgaccgcact caacaatttt       60

cagcagaatc cctacggccc gaatccggct gactacttgt cgaatgtcgg ctcttttcaa      120

cttatcgact cgaccctccg cgagggcgag cagttcgcca acgcgttctt ttccactgag      180

aagaaaatcg aaattgcccg tgctttggac gacttcggtg tcgattatat tgagctcacc      240

tccccggtgg cgtccgaaca gagccttcgc gactgtcagg ccatctgcaa gcttggcctc      300

aaggcaaaga ttctcacgca catccgttgc cacatggatg acgcaaaggt ggctgtgggc      360

accggagtcg atggagtgga tgtggtcatc ggaacctcta agttccttcg tcaatactcg      420

cacggtaagg acatgaacta tatcgctaag tccgcgattg aagttatcga gtacgtcaag      480

agcaaaggta ttgagatccg tttctcctcc gaggattcat tccgctcaga tctcgtggac      540

cttctgaaca tttataagac cgttgacaag attggtgtca atcgtgttgg aattgctgac      600

accgtcggat gcgcaaatcc acgccaggtt tacgagctcg tccgcaccct caaatccgtg      660

gtgtcatgcg acgtggaatg tcattttcac aacgataccg gctgcgccat cgcaaacgca      720

tacaccgctc tcgaaggagg cgccaaactc gtggacgtaa gcgtgctggg catcggtgag      780

cgtaatggta ttactccact cggtggcctg atggcccgta tgatcgtagc ggcaccagac      840

tacgtaaaat cgaagtacaa gcttcataag atccgcgaca ttgagaactt ggtggctgag      900

gcagtggagg tcaacgtgcc atttaataac ccaattaccg gtttctgcgc tttcacacat      960

aaagcaggaa ttcacgctaa ggcaatcctc gctaacccct ccacctatga aatcctgaac     1020

cctaacgatt ttggtatgac acgctacatc cacttcgcca accgtcttac cggctggaat     1080

gcaatcaagt ctcgcgtaga ccagcttaac ttgcacctca cggatgatca ggttaaagag     1140

gtgactgcca agattaaaca acttggcgat gttcgcccac tcaacatcga tgatgttgat     1200

agcatcatca aggcctttca cgcacagatc gcgacccctc gcgtgaccgc tcgaccagct     1260

aaccgtgaag aagaaattaa cggcttcgac cttgaagcgc ctccgcagaa gaagacgaag     1320

atcctc                                                                1326


<210>  50
<211>  381
<212>  PRT
<213>  Pseudomonas stutzeri

<400>  50

Met Ser Ile Val Ile Asp Asp Thr Thr Leu Arg Asp Gly Glu Gln Ser 
1               5                   10                  15      


Ala Gly Val Ala Phe Ser Ala Glu Glu Lys Leu Ala Ile Ala Arg Ala 
            20                  25                  30          


Leu Ala Gln Leu Gly Val Pro Glu Leu Glu Ile Gly Ile Pro Ser Met 
        35                  40                  45              


Gly Glu Glu Glu Cys Glu Val Met Arg Ala Ile Ala Gly Leu Ala Leu 
    50                  55                  60                  


Pro Val Arg Leu Leu Ala Trp Cys Arg Leu Cys Asp Ala Asp Leu Leu 
65                  70                  75                  80  


Ala Ala Gly Gly Thr Gly Val Gly Met Val Asp Leu Ser Leu Pro Val 
                85                  90                  95      


Ser Asp Leu Met Leu Gln His Lys Leu Gly Arg Asp Arg Asp Trp Ala 
            100                 105                 110         


Leu Arg Glu Ala Ala Arg Leu Val Gly Ala Ala Arg Asp Ala Gly Leu 
        115                 120                 125             


Glu Val Cys Leu Gly Cys Glu Asp Ala Ser Arg Ala Asp Pro Glu Phe 
    130                 135                 140                 


Ile Val Arg Val Ala Glu Val Ala Gln Ala Ala Gly Ala Arg Arg Leu 
145                 150                 155                 160 


Arg Phe Ala Asp Thr Val Gly Val Met Glu Pro Phe Ala Met His Ala 
                165                 170                 175     


Arg Phe Arg Phe Leu Ala Glu Arg Leu Asp Leu Glu Leu Glu Val His 
            180                 185                 190         


Ala His Asp Asp Phe Gly Leu Ala Thr Ala Asn Thr Leu Ala Ala Val 
        195                 200                 205             


Arg Gly Gly Ala Thr His Ile Asn Thr Thr Val Asn Gly Leu Gly Glu 
    210                 215                 220                 


Arg Ala Gly Asn Ala Ala Leu Glu Glu Cys Ala Leu Ala Leu Lys His 
225                 230                 235                 240 


Leu His Gly Ile Asp Cys Gly Ile Asp Val Arg Gly Ile Pro Ser Ile 
                245                 250                 255     


Ser Ala Leu Val Glu Gln Ala Ser Gly Arg Gln Val Ala Trp Gln Lys 
            260                 265                 270         


Ser Val Val Gly Ala Gly Val Phe Thr His Glu Ala Gly Ile His Val 
        275                 280                 285             


Asp Gly Leu Leu Lys His Arg Arg Asn Tyr Glu Gly Leu Asn Pro Asp 
    290                 295                 300                 


Glu Leu Gly Arg Ser His Ser Leu Val Leu Gly Lys His Ser Gly Ala 
305                 310                 315                 320 


His Met Val Glu Leu Ser Tyr Arg Glu Leu Gly Ile Glu Leu Gln Gln 
                325                 330                 335     


Trp Gln Ser Arg Ala Leu Leu Gly Cys Ile Arg Arg Phe Ser Thr Gln 
            340                 345                 350         


Thr Lys Arg Ser Pro Gln Ser Ala Asp Leu Gln Gly Phe Tyr Gln Gln 
        355                 360                 365             


Leu Cys Glu Gln Gly Leu Ala Leu Ala Gly Gly Ala Ala 
    370                 375                 380     


<210>  51
<211>  1143
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  51
atgtcaattg tcattgatga taccaccctc cgtgatggtg agcagtccgc gggcgtcgct       60

ttctctgcgg aggaaaagtt ggccatcgct cgcgctctgg cccaactggg tgtaccagaa      120

ttggaaattg gtatcccatc tatgggcgaa gaggaatgcg aagtgatgcg agctatcgca      180

ggactggcac tcccagtgcg ccttctggcc tggtgtcgtc tctgcgacgc agacttgctc      240

gctgcaggcg gcactggcgt gggcatggtg gatttgtcgt tgccggtgtc cgatcttatg      300

ctccaacaca aattgggtcg agatcgtgac tgggctctgc gtgaggccgc acgactcgtc      360

ggagctgcgc gtgacgcagg tctggaggtc tgcctgggtt gcgaagatgc cagccgtgca      420

gatcccgagt tcatcgtccg agtcgcagaa gtggcacaag ccgccggagc ccgtcgtctg      480

cgcttcgcag atactgtggg agtgatggaa ccctttgcca tgcatgcacg cttccgattc      540

ctggcagagc gactcgacct tgagctggaa gttcacgccc acgatgactt cggcctggcg      600

accgccaaca ccctcgcagc agttcgcggc ggagcgacac acattaacac cacggttaac      660

ggactgggag aacgcgcggg taatgctgct ctcgaagaat gtgcactcgc cctcaagcac      720

cttcacggca ttgactgcgg tatcgacgtg cgtggcatcc catccatctc cgcacttgtc      780

gaacaggcgt ccggacgcca ggtcgcctgg cagaaatctg tggtgggcgc aggtgtattc      840

acccacgagg caggaattca tgtcgacggc ctcctgaaac accgccgaaa ttatgagggt      900

ctcaatcctg atgagcttgg ccgtagccat tcactcgttt tgggcaagca ctcgggcgct      960

catatggtgg aactgtcata tcgcgaactg ggcatcgaac tccaacaatg gcaaagccgc     1020

gcactgttgg gctgcatccg acgcttttct acccaaacga agcgctcccc acagtccgca     1080

gacttgcagg gcttttacca gcaactctgt gaacagggac tcgccctcgc gggcggcgct     1140

gcc                                                                   1143


<210>  52
<211>  376
<212>  PRT
<213>  Unknown

<220>
<223>  Thermus sp. CCB_US3_UF1

<400>  52

Met Arg Glu Trp Arg Ile Ile Asp Ser Thr Leu Arg Glu Gly Glu Gln 
1               5                   10                  15      


Phe Glu Arg Ala Asn Phe Thr Thr Gln Asp Lys Val Leu Ile Ala Gln 
            20                  25                  30          


Ala Leu Asp Glu Phe Gly Ile Glu Tyr Ile Glu Val Thr Thr Pro Met 
        35                  40                  45              


Ala Ser Pro Gln Ser Arg Lys Asp Ala Glu Thr Leu Ala Ser Leu Gly 
    50                  55                  60                  


Leu Lys Ala Lys Val Val Thr His Ile Gln Thr Arg Leu Asp Ala Ala 
65                  70                  75                  80  


Glu Val Ala Val Glu Thr Gly Val Gln Gly Ile Asp Leu Leu Phe Gly 
                85                  90                  95      


Thr Ser Lys Tyr Leu Arg Ala Ala His Gly Arg Asp Ile Pro Arg Ile 
            100                 105                 110         


Ile Glu Glu Ala Arg Glu Val Ile Gln Tyr Ile Arg Glu Lys Ala Pro 
        115                 120                 125             


His Val Glu Val Arg Phe Ser Ala Glu Asp Thr Phe Arg Ser Asp Glu 
    130                 135                 140                 


His Asp Leu Leu Glu Ile Tyr Gly Ala Ile Ala Pro Tyr Val Asp Arg 
145                 150                 155                 160 


Val Gly Leu Ala Asp Thr Val Gly Ile Ala Thr Pro Arg Gln Val Tyr 
                165                 170                 175     


Ala Leu Val Arg Glu Val Arg Arg Val Val Gly Pro Glu Val Asp Ile 
            180                 185                 190         


Glu Phe His Gly His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala Phe 
        195                 200                 205             


Glu Ala Ile Glu Ala Gly Ala Thr His Val Asp Thr Thr Val Leu Gly 
    210                 215                 220                 


Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Phe Leu Ala Arg 
225                 230                 235                 240 


Met Tyr Thr Leu Gln Pro Glu Tyr Val Arg Gly Lys Tyr Lys Leu Glu 
                245                 250                 255     


Met Leu Pro Glu Leu Asp Arg Met Val Ala Arg Met Val Gly Val Glu 
            260                 265                 270         


Ile Pro Phe Asn Asn Tyr Ile Thr Gly Glu Thr Ala Phe Ser His Lys 
        275                 280                 285             


Ala Gly Met His Leu Lys Ala Ile Tyr Ile Asn Pro Glu Ser Tyr Glu 
    290                 295                 300                 


Pro Tyr Pro Pro Glu Val Phe Gly Val Arg Arg Lys Leu Ile Ile Ala 
305                 310                 315                 320 


Ser Lys Leu Thr Gly Arg His Ala Ile Arg Ala Arg Ala Glu Glu Leu 
                325                 330                 335     


Gly Leu His Tyr Gly Glu Glu Glu Leu Ala Arg Ile Thr Gln His Ile 
            340                 345                 350         


Lys Ala Leu Ala Asp Arg Gly Gln Leu Thr Leu Glu Glu Leu Asp Arg 
        355                 360                 365             


Ile Leu Arg Glu Trp Ile Thr Ala 
    370                 375     


<210>  53
<211>  1128
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  53
atgcgcgaat ggcgcatcat cgattccaca ctgcgcgagg gagaacagtt tgaacgcgct       60

aatttcacta cacaagataa agtcttgatc gcccaggctc tcgatgaatt cggcatcgaa      120

tatatcgagg ttaccacgcc gatggcctct cctcaatccc gtaaagatgc agagactttg      180

gcgtcattgg gcctcaaagc taaagttgtg actcatattc agacccgtct tgacgcagcg      240

gaagtcgcgg ttgaaacagg cgtgcagggc atcgatctcc ttttcggtac atccaagtac      300

ttgcgtgccg cccatggtcg cgacatcccc cgcatcatcg aagaagcccg cgaagtgatc      360

cagtacattc gcgaaaaggc cccgcacgtg gaagtgcgtt tctccgcgga agacacattt      420

cgctcagatg aacacgacct gttggagatt tacggcgcca tcgcaccgta cgtggatcgc      480

gtaggtttgg ccgacactgt gggcattgct acaccgcgac aggtctatgc gcttgtgcga      540

gaagtgcgcc gcgttgttgg acccgaagtg gacatcgagt ttcacggaca taatgacact      600

ggctgtgcta tcgccaatgc attcgaagcg attgaggcag gcgcaacgca cgtcgacacc      660

accgtgctcg gcatcggcga gcgtaacgga atcaccccgc tcggtggctt cctggcccgt      720

atgtacacct tgcaacccga gtacgttcgc ggaaaataca agctcgagat gctccctgaa      780

ttggatcgca tggtcgctcg catggtgggc gtcgaaattc ccttcaacaa ctatattacc      840

ggcgaaaccg cgttttctca caaagctggc atgcacctta aagctatcta cattaaccct      900

gagtcatatg aaccataccc tcctgaagtc ttcggcgtgc gccgcaagct cattatcgct      960

tccaagctta cgggtcgcca cgctattcgc gcacgtgctg aagaactcgg ccttcattac     1020

ggcgaggaag agctggctcg catcactcag cacattaaag ccctcgccga tcgcggacag     1080

cttacgctgg aagaattgga ccgtatcctc cgagaatgga tcaccgct                  1128


<210>  54
<211>  390
<212>  PRT
<213>  Methanobrevibacter smithii

<400>  54

Met Gln Tyr Tyr Ile Ser His Tyr Asn Lys Glu Pro Glu Leu Asn Phe 
1               5                   10                  15      


Pro Asp Glu Ile Thr Val Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln 
            20                  25                  30          


Thr Pro Gly Val Cys Phe Ser Pro Glu Glu Lys Leu Glu Ile Ala Lys 
        35                  40                  45              


Lys Leu Asp Glu Val Lys Ile Lys Gln Ile Glu Ala Gly Phe Pro Ile 
    50                  55                  60                  


Val Ser Lys Lys Glu Gln Glu Ser Val Lys Ala Ile Thr Ser Glu Gly 
65                  70                  75                  80  


Leu Asn Ala Gln Ile Ile Ser Leu Ser Arg Thr Lys Lys Glu Asp Ile 
                85                  90                  95      


Asp Ala Ala Leu Asp Cys Asp Val Asp Gly Val Ile Thr Phe Met Gly 
            100                 105                 110         


Thr Ser Asp Ile His Leu Glu His Lys Met His Ile Gly Arg Gln Glu 
        115                 120                 125             


Ala Leu Asn Thr Cys Met Asn Ala Ile Glu Tyr Ala Lys Asp His Gly 
    130                 135                 140                 


Leu Phe Val Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Asp Leu Asp 
145                 150                 155                 160 


Phe Leu Lys Arg Ile Tyr Asn Lys Ala Glu Ser Tyr Gly Ala Asp Arg 
                165                 170                 175     


Val His Ile Ala Asp Thr Thr Gly Ala Ile Thr Pro Gln Gly Ile Thr 
            180                 185                 190         


Tyr Leu Val Lys Glu Leu Lys Lys Asp Val Asn Ile Asp Ile Ala Leu 
        195                 200                 205             


His Cys His Asn Asp Phe Gly Leu Ala Val Ile Asn Ser Ile Ser Gly 
    210                 215                 220                 


Val Leu Ala Gly Ala Asn Gly Ile Ser Thr Thr Val Asn Gly Ile Gly 
225                 230                 235                 240 


Glu Arg Ala Gly Asn Ala Ser Leu Glu Glu Val Ile Met Ser Leu Lys 
                245                 250                 255     


Leu Leu Tyr Gly Lys Asp Leu Gly Phe Lys Thr Lys His Ile Lys Glu 
            260                 265                 270         


Leu Ser Glu Leu Val Ser Lys Ala Ser Gly Leu Pro Val Pro Tyr Asn 
        275                 280                 285             


Lys Pro Val Val Gly Asn Asn Val Phe Arg His Glu Ser Gly Ile His 
    290                 295                 300                 


Val Asp Ala Val Ile Glu Glu Pro Leu Cys Tyr Glu Pro Tyr Ile Pro 
305                 310                 315                 320 


Glu Leu Val Gly Gln Lys Arg Gln Leu Val Leu Gly Lys His Ser Gly 
                325                 330                 335     


Cys Arg Ala Val Arg Ala Lys Leu Asn Glu Cys Asp Leu Asp Val Ser 
            340                 345                 350         


Asp Asp Thr Leu Ile Glu Ile Val Lys Lys Val Lys Lys Ser Arg Glu 
        355                 360                 365             


Glu Gly Thr Tyr Ile Asn Asp Asp Val Phe Lys Glu Ile Val Lys Ser 
    370                 375                 380                 


Cys Asn Tyr Lys Lys Glu 
385                 390 


<210>  55
<211>  1170
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  55
atgcagtact acatttccca ttacaataaa gagccagagt tgaactttcc tgatgaaatc       60

accgtgtatg acacaactct gcgcgacggc gagcaaacgc ctggcgtctg cttctcgccg      120

gaagaaaaac tggaaatcgc gaaaaagctc gatgaggtga aaatcaagca gatcgaggca      180

ggcttcccaa ttgtgtctaa aaaggaacaa gaatcagtta aagctattac ctccgaggga      240

ctcaacgctc aaattatttc cttgtcacgc accaaaaagg aagatatcga tgccgcgctt      300

gattgcgatg tagacggcgt aattacattc atgggtacta gcgacattca tttggaacac      360

aagatgcata ttggccgtca ggaggccctg aacacctgca tgaatgcaat cgaatacgcc      420

aaggaccatg gtctctttgt ggctttttcc gcagaggatg cgacacgcac ggatctggat      480

ttcctgaagc gtatttacaa caaggctgag tcgtatggtg cagatcgcgt acacatcgcg      540

gacaccactg gcgcgatcac gccacaagga atcacctatc ttgttaaaga acttaagaaa      600

gacgtgaata ttgatattgc acttcattgt cataacgatt ttggtcttgc tgttatcaac      660

tcgatcagcg gcgtactggc cggtgctaat ggcatcagca ccacggtcaa cggaattggc      720

gaacgcgccg gtaacgcctc gctggaggaa gttatcatga gcctcaagct tttgtacgga      780

aaagacttgg gattcaagac aaagcacatt aaggaactct cggaattggt ctcaaaagct      840

tctggcctcc cggtgcctta taataaaccc gtggtgggta ataacgtttt ccgtcatgaa      900

tccggtatcc acgtcgacgc ggtgattgaa gagccactgt gctatgaacc gtacatcccc      960

gaacttgtcg gacagaaacg ccagttggtt ctcggaaaac acagcggctg ccgtgctgtt     1020

cgcgccaagc tcaacgagtg cgatctcgat gtatccgatg ataccctcat cgaaattgtg     1080

aagaaggtta agaaatcacg agaagaaggt acttacatca atgacgacgt tttcaaagaa     1140

attgtgaaat cctgtaacta caagaaagaa                                      1170


<210>  56
<211>  777
<212>  PRT
<213>  Neosartorya fumigata

<400>  56

Met Phe Lys Arg Thr Gly Ser Leu Leu Leu Arg Cys Arg Ala Ser Arg 
1               5                   10                  15      


Val Pro Val Ile Gly Arg Pro Leu Ile Ser Leu Ser Thr Ser Ser Thr 
            20                  25                  30          


Ser Leu Ser Leu Ser Arg Pro Arg Ser Phe Ala Thr Thr Ser Leu Arg 
        35                  40                  45              


Arg Tyr Thr Glu Ala Ser Ser Ser Thr Thr Gln Thr Ser Pro Ser Ser 
    50                  55                  60                  


Ser Ser Trp Pro Ala Pro Asp Ala Ala Pro Arg Val Pro Gln Thr Leu 
65                  70                  75                  80  


Thr Glu Lys Ile Val Gln Ala Tyr Ser Leu Gly Leu Ala Glu Gly Gln 
                85                  90                  95      


Tyr Val Lys Ala Gly Asp Tyr Val Met Leu Ser Pro His Arg Cys Met 
            100                 105                 110         


Thr His Asp Asn Ser Trp Pro Thr Ala Leu Lys Phe Met Ala Ile Gly 
        115                 120                 125             


Ala Ser Lys Val His Asn Pro Asp Gln Ile Val Met Thr Leu Asp His 
    130                 135                 140                 


Asp Val Gln Asn Lys Ser Glu Lys Asn Leu Lys Lys Tyr Glu Ser Ile 
145                 150                 155                 160 


Glu Lys Phe Ala Lys Gln His Gly Ile Asp Phe Tyr Pro Ala Gly His 
                165                 170                 175     


Gly Val Gly His Gln Ile Met Ile Glu Glu Gly Tyr Ala Phe Pro Gly 
            180                 185                 190         


Thr Val Thr Val Ala Ser Asp Ser His Ser Asn Met Tyr Gly Gly Val 
        195                 200                 205             


Gly Cys Leu Gly Thr Pro Met Val Arg Thr Asp Ala Ala Thr Ile Trp 
    210                 215                 220                 


Ala Thr Gly Arg Thr Trp Trp Lys Val Pro Pro Ile Ala Lys Val Gln 
225                 230                 235                 240 


Phe Thr Gly Thr Leu Pro Glu Gly Val Thr Gly Lys Asp Val Ile Val 
                245                 250                 255     


Ala Leu Ser Gly Leu Phe Asn Lys Asp Glu Val Leu Asn Tyr Ala Ile 
            260                 265                 270         


Glu Phe Thr Gly Ser Glu Glu Thr Met Lys Ser Leu Ser Val Asp Thr 
        275                 280                 285             


Arg Leu Thr Ile Ala Asn Met Thr Thr Glu Trp Gly Ala Leu Thr Gly 
    290                 295                 300                 


Leu Phe Pro Ile Asp Ser Thr Leu Glu Gln Trp Leu Arg His Lys Ala 
305                 310                 315                 320 


Ala Thr Ala Ser Arg Thr Glu Thr Ala Arg Arg Phe Ala Glu Glu Arg 
                325                 330                 335     


Ile Asn Glu Leu Phe Ala Asn Pro Thr Val Ala Asp Arg Gly Ala Arg 
            340                 345                 350         


Tyr Ala Lys Tyr Leu Tyr Leu Asp Leu Ser Thr Leu Ser Pro Tyr Val 
        355                 360                 365             


Ser Gly Pro Asn Ser Val Lys Val Ala Thr Pro Leu Asp Glu Leu Glu 
    370                 375                 380                 


Lys His Lys Leu Lys Ile Asp Lys Ala Tyr Leu Val Ser Cys Thr Asn 
385                 390                 395                 400 


Ser Arg Ala Ser Asp Ile Ala Ala Ala Ala Lys Val Phe Lys Asp Ala 
                405                 410                 415     


Val Ala Arg Thr Gly Gly Pro Val Arg Val Ala Asp Gly Val Glu Phe 
            420                 425                 430         


Tyr Val Ala Ala Ala Ser Lys Ala Glu Gln Lys Ile Ala Glu Glu Ala 
        435                 440                 445             


Gly Asp Trp Gln Ala Leu Met Asp Ala Gly Ala Ile Pro Leu Pro Ala 
    450                 455                 460                 


Gly Cys Ala Val Cys Ile Gly Leu Gly Ala Gly Leu Leu Lys Glu Gly 
465                 470                 475                 480 


Glu Val Gly Ile Ser Ala Ser Asn Arg Asn Phe Lys Gly Arg Met Gly 
                485                 490                 495     


Ser Pro Asp Ala Lys Ala Tyr Leu Ala Ser Pro Glu Val Val Ala Ala 
            500                 505                 510         


Ser Ala Leu Asn Gly Val Ile Ser Gly Pro Gly Ile Tyr Lys Arg Pro 
        515                 520                 525             


Glu Asp Trp Thr Gly Val Ser Ile Gly Glu Gly Glu Val Val Glu Ser 
    530                 535                 540                 


Gly Ser Arg Ile Asp Thr Thr Leu Glu Ala Met Glu Lys Phe Ile Gly 
545                 550                 555                 560 


Gln Leu Asp Ser Met Ile Asp Ser Ser Ser Lys Ala Val Met Pro Glu 
                565                 570                 575     


Glu Ser Thr Gly Ser Gly Ala Thr Glu Val Asp Ile Val Pro Gly Phe 
            580                 585                 590         


Pro Glu Lys Ile Glu Gly Glu Ile Leu Phe Leu Asp Ala Asp Asn Ile 
        595                 600                 605             


Ser Thr Asp Gly Ile Tyr Pro Gly Lys Tyr Thr Tyr Gln Asp Asp Val 
    610                 615                 620                 


Thr Lys Asp Lys Met Ala Gln Val Cys Met Glu Asn Tyr Asp Pro Ala 
625                 630                 635                 640 


Phe Ser Gly Ile Ala Arg Ala Gly Asp Ile Phe Val Ser Gly Phe Asn 
                645                 650                 655     


Phe Gly Cys Gly Ser Ser Arg Glu Gln Ala Ala Thr Ser Ile Leu Ala 
            660                 665                 670         


Lys Gln Leu Pro Leu Val Val Ala Gly Ser Ile Gly Asn Thr Phe Ser 
        675                 680                 685             


Arg Asn Ala Val Asn Asn Ala Leu Pro Leu Leu Glu Met Pro Arg Leu 
    690                 695                 700                 


Ile Glu Arg Leu Arg Glu Ala Phe Gly Ser Glu Lys Gln Pro Thr Arg 
705                 710                 715                 720 


Arg Thr Gly Trp Thr Phe Thr Trp Asn Val Arg Thr Ser Gln Val Thr 
                725                 730                 735     


Val Gln Glu Gly Pro Gly Gly Glu Thr Trp Ser Gln Ser Val Pro Ala 
            740                 745                 750         


Phe Pro Pro Asn Leu Gln Asp Ile Ile Ala Gln Gly Gly Leu Glu Lys 
        755                 760                 765             


Trp Val Lys Lys Glu Ile Ser Lys Ala 
    770                 775         


<210>  57
<211>  2331
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  57
atgttcaagc gcaccggttc acttcttttg cgatgccgtg cgtcccgcgt gcctgtgatc       60

ggacgtcccc tcattagcct cagcacctcc tccacgtccc tctctctgtc gcgcccccga      120

tccttcgcaa ctacttcgct tcgccgctat accgaagcat cctcatctac tacacagacc      180

tcccccagct cgtcatcgtg gccggctcca gatgcagccc cacgcgtgcc acaaactctc      240

acagaaaaga tcgtgcaagc gtatagcctc ggtctggcag aaggtcagta cgtcaaggcg      300

ggcgattacg tcatgctgtc cccgcaccgt tgtatgacac atgacaactc ctggccaacg      360

gcactgaagt tcatggcaat cggtgcttct aaggttcaca atcccgacca gatcgtgatg      420

accttggacc atgatgtcca gaataagagc gagaagaacc tgaagaaata tgaatctatc      480

gaaaaatttg ctaaacaaca cggaattgat ttttaccctg ccggccatgg cgtcggtcac      540

cagatcatga tcgaggaggg ctacgcgttc ccaggcaccg tgacagtcgc atcagactcc      600

cactctaaca tgtatggagg cgtgggttgt ttgggcaccc cgatggttcg caccgacgcg      660

gccaccattt gggctacagg tcgcacttgg tggaaagttc cccctatcgc aaaggtgcaa      720

ttcactggta cccttcccga aggagtgacg ggtaaagacg ttattgtggc attgtcaggt      780

ctcttcaata aggatgaggt gctgaattac gctattgagt tcaccggctc tgaagagacc      840

atgaagagcc tgtccgttga cacccgcttg actatcgcca acatgacgac agaatggggt      900

gcgttgactg gactcttccc tatcgattcg accctggagc agtggctgcg tcacaaagct      960

gccactgcgt ctcgtaccga aactgcgcgc cgcttcgccg aggaacgcat taatgagctg     1020

ttcgcaaacc ctaccgtcgc agaccgtggc gcacgttatg caaagtacct ttacctcgac     1080

ctgtccactc tgtccccata cgtgtccgga ccgaactccg ttaaggtcgc aacgcccctg     1140

gacgagctgg aaaagcacaa gctcaagatc gataaagcct atctggtctc ctgtactaac     1200

tctcgtgcat cggatattgc ggctgctgca aaagtgttca aggatgcggt tgcccgaacg     1260

ggcggacccg tccgagttgc tgatggcgtg gaattctatg tcgccgcagc ctccaaagcg     1320

gaacagaaga tcgctgagga ggctggcgac tggcaggctc tgatggatgc tggcgcgatc     1380

ccgttgcctg caggctgtgc cgtgtgcatc ggtcttggcg caggtctcct caaggagggc     1440

gaggtgggca tttccgcatc gaaccgcaat tttaagggtc gcatgggctc tccagatgca     1500

aaggcatatt tggctagccc cgaagtcgtc gccgcaagcg ccttgaacgg cgtcatcagc     1560

ggccccggca tctacaaacg cccagaggac tggaccggtg tctcgatcgg tgagggcgag     1620

gtcgttgaat ccggttcccg tattgatacg accctcgaag ctatggaaaa atttatcggc     1680

caattggact ccatgatcga tagcagctcc aaggcagtca tgccagagga aagcactgga     1740

tccggtgcaa cggaggtaga tatcgtcccc ggattcccag aaaagatcga gggcgaaatt     1800

ctctttttgg acgctgataa cattagcact gatggcatct acccaggtaa gtacacctac     1860

caggacgacg tgacaaagga taaaatggct caagtctgca tggaaaacta cgatcccgca     1920

ttctccggca ttgcacgtgc tggtgatatt ttcgtgtctg gcttcaattt tggctgcggt     1980

tcctcccgtg aacaagcagc gacttccatc cttgctaagc agctccccct cgtggtggcg     2040

ggttccattg gcaacacctt tagccgcaac gcggtgaata acgctcttcc ccttctggag     2100

atgccgcgcc tcatcgaacg cctccgagag gctttcggtt ctgaaaaaca gccgacccgc     2160

cgcaccggtt ggacatttac atggaacgtt cgcacctccc aggtcaccgt gcaggaaggc     2220

cccggaggcg agacctggtc ccaatccgtg ccagctttcc cccctaactt gcaggacatt     2280

attgcacagg gtggtttgga gaagtgggtc aaaaaagaga tcagcaaagc t              2331


<210>  58
<211>  378
<212>  PRT
<213>  Unknown

<220>
<223>  Burkholderia sp. KJ006

<400>  58

Met Ser Ile Pro Ile Ile Asn Asp Thr Thr Leu Arg Asp Gly Glu Gln 
1               5                   10                  15      


Thr Ala Gly Val Ala Phe Thr Val Glu Glu Lys Cys Ala Ile Ala Thr 
            20                  25                  30          


Ala Leu Ser Asn Ala Gly Val Pro Glu Leu Glu Ile Gly Ile Pro Ser 
        35                  40                  45              


Met Gly Ala Asp Glu Ile Ala Asp Ile Arg Ser Ile Val Asp Leu Asn 
    50                  55                  60                  


Leu Asp Ala Ser Val Met Val Trp Gly Arg Leu Thr Pro Gly Asp Leu 
65                  70                  75                  80  


Ala Ala Ala Leu Arg Ser Arg Pro Asp Ile Ile His Leu Ser Val Pro 
                85                  90                  95      


Val Ser Asp Ile His Leu Gln Tyr Lys Leu Arg Gln Pro Arg Ala Trp 
            100                 105                 110         


Val Phe Ala Gln Ile Lys Arg Val Ile Gly Glu Ala Val Arg Ser Asp 
        115                 120                 125             


Leu Lys Ile Ser Leu Gly Ala Glu Asp Ala Ser Arg Ala Asp Pro Ala 
    130                 135                 140                 


Phe Leu Ala Asp Val Ala Arg Leu Ala Gln Gln Cys Gly Ala Gln Arg 
145                 150                 155                 160 


Ile Arg Phe Ala Asp Thr Leu Gly Val Leu Asp Pro Phe Ser Thr Tyr 
                165                 170                 175     


Glu Ala Val Ala Arg Leu Arg Asp Ala Val Asp Ile Glu Ile Glu Met 
            180                 185                 190         


His Ala His Asn Asp Leu Gly Leu Ala Thr Ala Asn Thr Leu Ala Ala 
        195                 200                 205             


Leu Arg Ala Gly Ala Thr His Ala Asn Thr Thr Val Asn Gly Leu Gly 
    210                 215                 220                 


Glu Arg Ala Gly Asn Ala Ala Leu Glu Glu Val Val Met Cys Ser Arg 
225                 230                 235                 240 


His Leu Leu Gly Arg Asp Thr Gly Val Asp Thr Thr Ala Leu Val Gly 
                245                 250                 255     


Ile Ser Arg Leu Val Glu His Ala Ser Gly Arg Gln Val Ala Leu Asn 
            260                 265                 270         


Lys Ser Ile Val Gly Gly Gly Val Phe Thr His Glu Ser Gly Ile His 
        275                 280                 285             


Thr Asp Gly Leu Ala Lys Asn Pro Thr Thr Tyr Glu Ser Phe Asp Pro 
    290                 295                 300                 


Ala Glu Leu Gly Arg Ala Arg Ser Leu Val Leu Gly Lys His Ser Gly 
305                 310                 315                 320 


Ser His Gly Val Arg His Ala Tyr Glu Ala Leu Gly Leu Pro Val Ala 
                325                 330                 335     


Asp Gln Leu Val Pro Leu Leu Leu Ala Arg Ile Arg Gln His Ala Thr 
            340                 345                 350         


Gln Thr Lys Gln Ala Pro Asn Ala Ala Asp Leu Tyr Arg Phe Leu Val 
        355                 360                 365             


Glu Thr Arg Glu Leu Val Glu Glu Trp Ser 
    370                 375             


<210>  59
<211>  1134
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  59
atgtccattc ctatcattaa cgatacgacc ctccgcgacg gcgaacagac cgcgggagtc       60

gcattcactg tagaagagaa gtgtgctatt gcgaccgcac tttccaacgc cggtgttccc      120

gaacttgaga ttggcattcc atccatggga gcagacgaaa ttgctgacat ccgaagcatc      180

gtggacctca acctggacgc gtcagttatg gtatggggcc gattgacccc tggtgacctc      240

gcagcggctc tccgctcccg cccagacatt atccacttgt ccgtgccggt gtccgatatc      300

catctgcagt ataagttgcg acaaccgcgc gcctgggtgt tcgcccaaat taaacgcgtt      360

atcggtgagg ccgtccgttc cgacctcaaa atctccctgg gtgcagaaga cgctagccgt      420

gctgaccctg ccttcctggc cgacgtggct cgtttggcgc aacagtgcgg tgcacaacgc      480

atccgcttcg ctgatacgct cggcgtgctc gacccctttt caacgtacga agcagtcgca      540

cgcctccgtg acgctgtaga catcgagatc gaaatgcacg cacacaacga tctgggcttg      600

gcgaccgcga acaccttggc tgcgttgcgc gctggcgcaa cccacgcaaa taccacggtc      660

aatggcctcg gtgaacgtgc gggaaacgca gccttggagg aagtcgttat gtgttcacgc      720

catcttcttg gtcgagatac aggagtcgat accacggcac tggtgggtat ttcccgtctg      780

gtcgaacacg catctggccg ccaggttgca ctgaacaagt caatcgtcgg tggaggtgtc      840

ttcacacatg aatccggcat ccataccgac ggtttggcta aaaatccaac cacgtacgag      900

tcattcgacc cagcagaact gggccgtgca cgctcccttg tcctcggcaa gcacagcggc      960

tcccacggtg ttcgacatgc atatgaggca cttggtctgc cagttgcgga tcagctggtg     1020

ccccttctcc ttgcccgcat ccgtcaacat gcgactcaga ccaagcaagc tccaaacgcg     1080

gcggacttgt atcgcttctt ggtggaaacc cgcgaacttg tggaagagtg gtca           1134


<210>  60
<211>  385
<212>  PRT
<213>  Azotobacter vinelandii

<400>  60

Met Ala Ser Val Ile Ile Asp Asp Thr Thr Leu Arg Asp Gly Glu Gln 
1               5                   10                  15      


Ser Ala Gly Val Ala Phe Asn Ala Asp Glu Lys Ile Ala Ile Ala Arg 
            20                  25                  30          


Ala Leu Ala Glu Leu Gly Val Pro Glu Leu Glu Ile Gly Ile Pro Ser 
        35                  40                  45              


Met Gly Glu Glu Glu Arg Glu Val Met His Ala Ile Ala Gly Leu Gly 
    50                  55                  60                  


Leu Ser Ser Arg Leu Leu Ala Trp Cys Arg Leu Cys Asp Val Asp Leu 
65                  70                  75                  80  


Ala Ala Ala Arg Ser Thr Gly Val Thr Met Val Asp Leu Ser Leu Pro 
                85                  90                  95      


Val Ser Asp Leu Met Leu His His Lys Leu Asn Arg Asp Arg Asp Trp 
            100                 105                 110         


Ala Leu Arg Glu Val Ala Arg Leu Val Gly Glu Ala Arg Met Ala Gly 
        115                 120                 125             


Leu Glu Val Cys Leu Gly Cys Glu Asp Ala Ser Arg Ala Asp Leu Glu 
    130                 135                 140                 


Phe Val Val Gln Val Gly Glu Val Ala Gln Ala Ala Gly Ala Arg Arg 
145                 150                 155                 160 


Leu Arg Phe Ala Asp Thr Val Gly Val Met Glu Pro Phe Gly Met Leu 
                165                 170                 175     


Asp Arg Phe Arg Phe Leu Ser Arg Arg Leu Asp Met Glu Leu Glu Val 
            180                 185                 190         


His Ala His Asp Asp Phe Gly Leu Ala Thr Ala Asn Thr Leu Ala Ala 
        195                 200                 205             


Val Met Gly Gly Ala Thr His Ile Asn Thr Thr Val Asn Gly Leu Gly 
    210                 215                 220                 


Glu Arg Ala Gly Asn Ala Ala Leu Glu Glu Cys Val Leu Ala Leu Lys 
225                 230                 235                 240 


Asn Leu His Gly Ile Asp Thr Gly Ile Asp Thr Arg Gly Ile Pro Ala 
                245                 250                 255     


Ile Ser Ala Leu Val Glu Arg Ala Ser Gly Arg Gln Val Ala Trp Gln 
            260                 265                 270         


Lys Ser Val Val Gly Ala Gly Val Phe Thr His Glu Ala Gly Ile His 
        275                 280                 285             


Val Asp Gly Leu Leu Lys His Arg Arg Asn Tyr Glu Gly Leu Asn Pro 
    290                 295                 300                 


Asp Glu Leu Gly Arg Ser His Ser Leu Val Leu Gly Lys His Ser Gly 
305                 310                 315                 320 


Ala His Met Val Arg Asn Thr Tyr Arg Asp Leu Gly Ile Glu Leu Ala 
                325                 330                 335     


Asp Trp Gln Ser Gln Ala Leu Leu Gly Arg Ile Arg Ala Phe Ser Thr 
            340                 345                 350         


Arg Thr Lys Arg Arg Ser Pro Gln Pro Ala Glu Leu Gln Asp Phe Tyr 
        355                 360                 365             


Arg Gln Leu Cys Glu Gln Gly Asn Pro Glu Leu Ala Ala Gly Gly Met 
    370                 375                 380                 


Ala 
385 


<210>  61
<211>  1155
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  61
atggcaagcg taattattga cgacacgact ctccgtgatg gtgaacagtc tgcgggcgtt       60

gctttcaatg ccgatgagaa gattgccatt gctcgtgcct tggccgaatt gggagtccct      120

gaattggaaa tcggaattcc atctatgggc gaggaagagc gagaagtgat gcacgccatc      180

gcgggactgg gtttgtcatc ccgtctcctc gcctggtgcc gcctctgcga cgttgacctg      240

gcagctgcgc gctctaccgg cgtgactatg gtggacttgt cacttcctgt ttctgacctg      300

atgttgcacc ataaactcaa tcgcgaccgc gactgggcgt tgcgtgaagt ggcccgtctt      360

gtcggagaag cgcgtatggc aggactcgaa gtgtgtttgg gttgcgagga cgcgtcccgt      420

gcggatttgg agtttgtggt ccaggtgggc gaagtggccc aggccgccgg tgcccgacgc      480

ttgcgtttcg cagacacggt cggtgtgatg gagcctttcg gtatgttgga tcgcttccga      540

tttctttccc gtcgcttgga catggaactg gaggtccacg cacacgacga cttcggcctc      600

gccaccgcaa ataccctcgc agcagttatg ggaggtgcta cccacatcaa caccaccgtg      660

aatggtcttg gcgagcgcgc gggaaacgct gcgttggaag agtgcgttct ggccttgaag      720

aacctgcacg gtattgatac aggcatcgac acccgtggca tcccggcgat ttccgcgctg      780

gtcgaacgtg cgtcgggccg tcaggttgcc tggcagaagt ccgtggtagg cgccggtgtg      840

ttcactcatg aagcaggtat tcacgtggat ggcctgttga agcaccgtcg taactacgaa      900

ggccttaacc ctgatgaact gggccgatcc cactccctcg tgctgggcaa acacagcgga      960

gcacatatgg tccgtaacac ctatcgcgac ctgggcattg agctggctga ttggcagtcc     1020

caagcgcttc tgggtcgtat ccgtgcgttc tccacacgta ccaagcgccg cagcccacaa     1080

cccgctgaac tgcaggattt ctaccgccag ttgtgtgagc aaggcaaccc tgagctggca     1140

gcgggtggca tggct                                                      1155


<210>  62
<211>  374
<212>  PRT
<213>  Methylomonas denitrificans

<400>  62

Met Lys Ser Asn Ser Arg Thr Ile Val Ile Asp Asp Thr Thr Leu Arg 
1               5                   10                  15      


Asp Gly Glu Gln Ser Ala Gly Val Val Phe Ser Leu Glu Glu Lys Leu 
            20                  25                  30          


Ala Ile Ala Gly Gln Leu Ser Ala Leu Gly Val Pro Glu Leu Glu Ile 
        35                  40                  45              


Gly Ile Pro Ala Met Gly Ala Gln Glu Arg Asp Glu Ile Lys Ala Ile 
    50                  55                  60                  


Ala Ala Leu Lys Leu Pro Ser Asn Leu Leu Val Trp Ser Arg Met Arg 
65                  70                  75                  80  


Glu Glu Asp Leu Gln His Cys Leu Gly Leu Gly Val Gly Thr Val Asp 
                85                  90                  95      


Leu Ser Ile Ser Ala Ser Asp Gln His Ile Gln His Lys Leu Lys Gln 
            100                 105                 110         


Ser Arg Ala Trp Val Leu Ala Thr Ile Glu Arg Cys Val Lys Thr Ala 
        115                 120                 125             


Val Asp Ala Gly Met Gln Val Cys Val Gly Ala Glu Asp Ala Ser Arg 
    130                 135                 140                 


Ala Asp Gly Asp Phe Leu Ala Leu Met Ala Glu Ala Ala Gln Ala Ala 
145                 150                 155                 160 


Gly Ala Cys Arg Ile Arg Phe Ala Asp Thr Val Gly Ile Met Glu Pro 
                165                 170                 175     


Phe Gly Val Phe Glu Ala Ile Arg Lys Leu Arg Ala Val Thr Asp Met 
            180                 185                 190         


Asp Ile Glu Met His Ala His Asp Asp Leu Gly Leu Ala Thr Ala Asn 
        195                 200                 205             


Thr Leu Ala Ala Ala Tyr Ala Gly Ala Thr His Val Asn Thr Thr Val 
    210                 215                 220                 


Asn Gly Leu Gly Glu Arg Ala Gly Asn Ala Ala Leu Glu Glu Val Val 
225                 230                 235                 240 


Val Gly Leu Lys Gln Leu Tyr Gly Phe Glu Thr Gly Val Asp Leu Arg 
                245                 250                 255     


Asn Phe Pro Ala Leu Ser Arg Gln Val Ala Thr Ala Ser Gly Asp Thr 
            260                 265                 270         


Ile Gly Ser Arg Lys Ser Leu Ile Gly Arg Asp Val Phe Ser His Glu 
        275                 280                 285             


Ala Gly Ile His Val Asp Gly Leu Leu Lys Asp Pro Asn Asn Tyr Gln 
    290                 295                 300                 


Gly Val Asp Pro Ala Leu Val Gly Arg Ser His Gln Leu Val Leu Gly 
305                 310                 315                 320 


Lys His Ser Gly Ser Gln Gly Val Met His Ala Tyr Lys Gln Leu Gly 
                325                 330                 335     


Ile Gln Ile Asn Arg Trp Gln Ala Gly Arg Leu Leu Pro Leu Ile Arg 
            340                 345                 350         


Glu Phe Val Ser Leu His Lys Arg Ala Pro Gln Ser Thr Asp Leu Asn 
        355                 360                 365             


Gln Phe Leu His Ser Leu 
    370                 


<210>  63
<211>  1122
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  63
atgaagagca actcccgcac cattgtgatc gacgatacca cgttgcgtga tggcgagcag       60

tcagccggcg tggtcttctc tctggaagaa aagctcgcta tcgctggcca actgagcgcg      120

ttgggtgtcc ctgaactcga aatcggtatt cccgccatgg gagcgcagga gcgcgatgaa      180

atcaaggcca tcgcagcgct gaagcttcct tcaaacctgc tggtgtggtc acgcatgcgc      240

gaagaggacc ttcagcattg tctcggtttg ggcgttggta ctgtggatct gtccatctcc      300

gcatcagacc agcacatcca gcacaagctt aaacaaagcc gcgcatgggt gcttgcaaca      360

attgagcgct gcgttaagac ggccgtggac gcaggtatgc aggtgtgcgt aggcgctgaa      420

gacgccagcc gcgcggatgg cgacttcctc gcccttatgg cagaagcggc acaagcggcc      480

ggagcgtgcc gtattcgctt cgccgataca gtcggcatca tggaaccttt tggtgtcttc      540

gaagccattc gtaagctgcg tgccgtgact gatatggaca tcgaaatgca cgcacatgat      600

gatcttggct tggctacagc taatacgctc gccgcagcgt acgccggtgc gacccacgtg      660

aacacgacag tgaatggact gggtgagcgc gctggtaacg ctgctcttga ggaagttgtg      720

gtcggcctta aacagctgta cggcttcgag accggcgtcg acctgcgtaa ctttcctgct      780

ctgtcccgtc aagttgcaac ggcttcgggt gataccatcg gttctcgaaa atccctcatt      840

ggtcgtgacg tgttctccca tgaggcagga atccatgttg acggtctcct gaaagatccg      900

aacaactacc aaggtgtgga cccagccctg gttggtcgca gccaccagct tgtgctgggc      960

aagcactccg gctcccaggg cgttatgcat gcgtacaagc agcttggcat tcaaatcaac     1020

cgttggcaag caggccgcct cctccctctg attcgagaat ttgtttctct ccacaagcgt     1080

gcaccccaga gcactgatct gaaccagttt ctccactccc tg                        1122


<210>  64
<211>  418
<212>  PRT
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  64

Met Ser Val Ser Glu Ala Asn Gly Thr Glu Thr Ile Lys Pro Pro Met 
1               5                   10                  15      


Asn Gly Asn Pro Tyr Gly Pro Asn Pro Ser Asp Phe Leu Ser Arg Val 
            20                  25                  30          


Asn Asn Phe Ser Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe 
        35                  40                  45              


Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Gln Ile Ala Lys Ala 
    50                  55                  60                  


Leu Asp Asn Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro Val Ala 
65                  70                  75                  80  


Ser Glu Gln Ser Arg Gln Asp Cys Glu Ala Ile Cys Lys Leu Gly Leu 
                85                  90                  95      


Lys Cys Lys Ile Leu Thr His Ile Arg Cys His Met Asp Asp Ala Arg 
            100                 105                 110         


Val Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val Ile Gly Thr 
        115                 120                 125             


Ser Gln Tyr Leu Arg Lys Tyr Ser His Gly Lys Asp Met Thr Tyr Ile 
    130                 135                 140                 


Ile Asp Ser Ala Thr Glu Val Ile Asn Phe Val Lys Ser Lys Gly Ile 
145                 150                 155                 160 


Glu Val Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp 
                165                 170                 175     


Leu Leu Ser Leu Tyr Lys Ala Val Asp Lys Ile Gly Val Asn Arg Val 
            180                 185                 190         


Gly Ile Ala Asp Thr Val Gly Cys Ala Thr Pro Arg Gln Val Tyr Asp 
        195                 200                 205             


Leu Ile Arg Thr Leu Arg Gly Val Val Ser Cys Asp Ile Glu Cys His 
    210                 215                 220                 


Phe His Asn Asp Thr Gly Met Ala Ile Ala Asn Ala Tyr Cys Ala Leu 
225                 230                 235                 240 


Glu Ala Gly Ala Thr His Ile Asp Thr Ser Ile Leu Gly Ile Gly Glu 
                245                 250                 255     


Arg Asn Gly Ile Thr Pro Leu Gly Ala Leu Leu Ala Arg Met Tyr Val 
            260                 265                 270         


Thr Asp Lys Glu Tyr Ile Thr His Lys Tyr Lys Leu Asn Gln Leu Arg 
        275                 280                 285             


Glu Leu Glu Asn Leu Val Ala Asp Ala Val Glu Val Gln Ile Pro Phe 
    290                 295                 300                 


Asn Asn Tyr Ile Thr Gly Met Cys Ala Phe Thr His Lys Ala Gly Ile 
305                 310                 315                 320 


His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu Ile Leu Lys 
                325                 330                 335     


Pro Glu Asp Phe Gly Met Ser Arg Tyr Val His Val Gly Ser Arg Leu 
            340                 345                 350         


Thr Gly Trp Asn Ala Ile Lys Ser Arg Ala Glu Gln Leu Asn Leu His 
        355                 360                 365             


Leu Thr Asp Ala Gln Ala Lys Glu Leu Thr Val Arg Ile Lys Lys Leu 
    370                 375                 380                 


Ala Asp Val Arg Thr Leu Ala Met Asp Asp Val Asp Arg Val Leu Arg 
385                 390                 395                 400 


Glu Tyr His Ala Asp Leu Ser Asp Ala Asp Arg Ile Thr Lys Glu Ala 
                405                 410                 415     


Ser Ala 
        


<210>  65
<211>  1254
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  65
atgtccgtca gcgaggccaa cggaacggag acgatcaaac cgccaatgaa cggaaatccg       60

tatggcccta acccctcaga tttcctctca cgcgtcaata acttctcaat tatcgaatct      120

actttgcgcg aaggcgaaca atttgccaac gctttcttcg ataccgagaa gaagatccaa      180

attgccaagg cgcttgataa cttcggcgtg gattacatcg aacttaccag cccggtagcc      240

tctgaacagt cccgccagga ctgtgaagca atctgtaagc tcggcctcaa gtgcaaaatc      300

cttacccata ttcgctgcca catggatgac gcacgcgtcg cagtggagac aggtgtggac      360

ggcgtcgatg tggtaatcgg cacttcccag tatctgcgca agtactctca tggtaaagat      420

atgacctata ttattgattc tgcaaccgaa gtgatcaact tcgtcaaatc caaaggtatt      480

gaggtccgtt tttcttccga ggactcattc cgctcggatc tcgtcgatct gctgtccctg      540

tacaaggcag ttgataagat cggcgtgaac cgcgtgggca ttgccgatac cgtgggatgc      600

gcgacccctc gacaagtgta tgatttgatc cgaacccttc gcggcgtggt atcctgcgac      660

atcgagtgcc acttccacaa cgatactgga atggcgattg cgaatgccta ctgcgccctg      720

gaagcaggag caactcatat tgatacttcc attttgggca tcggcgaacg caacggtatt      780

acgccacttg gagccctcct cgcacgaatg tacgtaaccg acaaggagta tattacccac      840

aagtacaaac tcaatcagct gcgtgaactg gagaacttgg tggcggatgc cgtggaggtt      900

cagatcccat tcaataacta cattacgggc atgtgcgcct tcacacacaa ggcaggtatc      960

cacgccaagg caatcctggc aaacccgtct acctacgaga tcctgaagcc cgaagatttc     1020

ggaatgtccc gatacgtgca cgttggctca cgcctcaccg gctggaatgc tattaaatcc     1080

cgcgccgaac agcttaacct ccacttgacg gacgctcaag cgaaggaact taccgtacgc     1140

attaaaaagc tcgccgacgt ccgtaccctg gctatggacg atgttgatcg cgttttgcgt     1200

gagtatcacg cggatctgtc tgatgctgat cgtattacga aggaggcctc cgcc           1254


<210>  66
<211>  425
<212>  PRT
<213>  Neurospora crassa

<400>  66

Met Cys Gly Thr Asp Ala Pro Asn Gly Thr Asn Gly Ala Ser Asn Gly 
1               5                   10                  15      


Val Asn Pro Ala Asn Phe Arg Ser Asn Pro Tyr Gln Pro Val Gly Asp 
            20                  25                  30          


Phe Leu Ser Asn Val Gly Ser Phe Lys Ile Ile Glu Ser Thr Leu Arg 
        35                  40                  45              


Glu Gly Glu Gln Phe Ala Asn Ala Tyr Phe Asp Thr Glu Thr Lys Ile 
    50                  55                  60                  


Lys Ile Ala Lys Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu 
65                  70                  75                  80  


Thr Ser Pro Ala Ala Ser Glu Gln Ser Arg Arg Asp Cys Glu Ala Ile 
                85                  90                  95      


Cys Lys Leu Gly Leu Lys Ala Lys Ile Leu Thr His Val Arg Cys Asp 
            100                 105                 110         


Met Arg Asp Ala Gln Leu Ala Val Glu Thr Gly Val Asp Gly Leu Asp 
        115                 120                 125             


Val Val Ile Gly Thr Ser Ser Phe Leu Arg Glu His Ser His Gly Lys 
    130                 135                 140                 


Asp Met Ala Tyr Ile Glu Lys Thr Ala Val Glu Val Ile Glu Tyr Val 
145                 150                 155                 160 


Lys Ser Lys Gly Leu Glu Val Arg Phe Ser Ser Glu Asp Ser Phe Arg 
                165                 170                 175     


Ser Asp Leu Val Asp Leu Leu Ser Leu Tyr Arg Ala Val Asp Lys Val 
            180                 185                 190         


Gly Val His Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Ser Pro 
        195                 200                 205             


Arg Gln Val Tyr Asp Leu Val Arg Thr Leu Arg Gly Val Val Ser Cys 
    210                 215                 220                 


Asp Ile Glu Thr His Phe His Asp Asp Thr Gly Cys Ala Ile Ala Asn 
225                 230                 235                 240 


Ala Tyr Cys Ala Leu Glu Ala Gly Ala Thr His Ile Asp Thr Ser Val 
                245                 250                 255     


Leu Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met 
            260                 265                 270         


Ala Arg Met Ile Val Thr Ser Pro Asp Tyr Val Lys Ser Lys Tyr Lys 
        275                 280                 285             


Leu His Lys Leu Lys Glu Leu Glu Asp Leu Val Ala Glu Ala Val Glu 
    290                 295                 300                 


Ile Asn Thr Pro Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe Thr 
305                 310                 315                 320 


His Lys Ala Gly Ile His Ala Lys Ala Ile Leu Asn Asn Pro Ser Thr 
                325                 330                 335     


Tyr Glu Ile Leu Asn Pro Ala Asp Phe Gly Leu Thr Arg Tyr Val His 
            340                 345                 350         


Phe Ala Ser Arg Leu Thr Gly Trp Asn Ala Val Lys Thr Arg Val Gly 
        355                 360                 365             


Gln Leu Gly Leu Glu Met Thr Asp Asp Gln Val Lys Glu Cys Thr Ala 
    370                 375                 380                 


Lys Ile Lys Ala Leu Ala Asp Val Arg Pro Ile Ala Ile Asp Asp Ala 
385                 390                 395                 400 


Asp Ser Ile Ile Arg Thr Phe His Leu Gly Leu His Glu Gln Asn Lys 
                405                 410                 415     


Val Gln Pro Pro Ala Val Val Glu Asn 
            420                 425 


<210>  67
<211>  1275
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  67
atgtgtggaa ccgatgctcc caacggtact aacggagcct ccaatggcgt caaccccgca       60

aatttccgct ccaacccgta tcagcctgtt ggtgattttc tgtcgaatgt gggtagcttt      120

aagatcatcg aatccaccct tcgcgagggc gaacagtttg cgaacgctta cttcgatacc      180

gagacgaaga tcaagattgc aaaggccttg gacgatttcg gcgttgacta cattgagctt      240

acttctcctg ccgcgtcaga acaatcacgc cgcgattgtg aggctatctg caagcttggc      300

ttgaaagcga aaatcttgac ccatgttcgc tgcgacatgc gcgatgctca actggcagtg      360

gaaacaggcg tggatggtct ggacgtcgtc atcggcacct cgtcgttcct gcgcgaacac      420

tcccacggaa aggacatggc gtacattgag aaaacagcag tggaagtgat cgagtatgtg      480

aaatcgaaag gactggaagt gcgattctcc tccgaagact cattccgttc tgacctcgtc      540

gaccttctct ccctgtaccg cgcggtcgat aaagtgggag ttcaccgcgt cggtatcgcg      600

gacacggttg gctgtgcctc gccacgccag gtatacgatc ttgttcgtac tcttcgcggc      660

gtcgtctcgt gcgacatcga gacacacttt catgatgaca caggctgtgc aatcgctaac      720

gcatattgtg ctctggaggc aggtgctacc cacatcgata cgagcgtgct tggcattggc      780

gaacgcaacg gtattacgcc cctcggtgga cttatggcgc gcatgattgt gacttcccct      840

gactatgtga agtccaaata caagcttcac aagctgaaag agctggaaga tttggttgcc      900

gaggcggtgg agattaacac cccttttaat aacccgatta ccggtttttg cgcgttcacc      960

cataaagccg gaatccacgc aaaagcaatc ctgaacaatc cgtctacgta cgaaatcctt     1020

aacccggccg actttggttt gacccgctat gtacacttcg cctcgcgcct caccggttgg     1080

aacgcagtta agacccgcgt cggtcagttg ggtctcgaaa tgactgacga tcaggtaaag     1140

gagtgcactg caaagattaa ggcactcgcc gacgttcgcc caattgcgat cgatgacgca     1200

gactctatca ttcgcacatt ccacctcggt ttgcacgaac agaacaaagt tcagcctccg     1260

gcggttgttg agaac                                                      1275


<210>  68
<211>  397
<212>  PRT
<213>  Clostridioides difficile

<400>  68

Met Cys Val Ile Ser Lys Asp Arg Ala Lys Glu Ile Lys Ile Val Asp 
1               5                   10                  15      


Thr Thr Leu Arg Asp Gly Glu Gln Thr Ala Gly Val Val Phe Ala Asn 
            20                  25                  30          


Arg Glu Lys Ile Met Ile Ala Glu Met Leu Ser Asp Leu Gly Val Asp 
        35                  40                  45              


Gln Ile Glu Val Gly Ile Pro Thr Met Gly Gly Asp Glu Lys Asn Val 
    50                  55                  60                  


Ile Lys His Ile Cys Ser Arg Asn Leu Lys Ser Asp Ile Met Ala Trp 
65                  70                  75                  80  


Asn Arg Ala Val Ile Lys Asp Val Glu Glu Ser Ile Ser Cys Gly Val 
                85                  90                  95      


Asp Ala Val Ala Ile Ser Ile Ser Val Ser Asp Ile His Ile Glu Asn 
            100                 105                 110         


Lys Leu Arg Thr Ser Arg Gly Trp Val Leu Glu Asn Met Ala Lys Thr 
        115                 120                 125             


Val Glu Phe Ala Lys Lys Asn Gly Leu Tyr Val Ser Val Asn Gly Glu 
    130                 135                 140                 


Asp Ala Ser Arg Ala Asp Ile Asp Phe Leu Thr Glu Phe Ile Asn Val 
145                 150                 155                 160 


Gly Lys Gln Ala Gly Ala Asp Arg Phe Arg Tyr Cys Asp Thr Val Gly 
                165                 170                 175     


Val Met Asn Pro Phe Ser Ile Lys Asn Ala Ile Glu Thr Leu Tyr Glu 
            180                 185                 190         


Arg Thr Asn Phe Asp Ile Glu Met His Thr His Asn Asp Phe Gly Met 
        195                 200                 205             


Ala Thr Ala Asn Ala Leu Ala Gly Ile Ala Ala Gly Ala Asn Tyr Val 
    210                 215                 220                 


Gly Val Thr Val Asn Gly Leu Gly Glu Arg Ala Gly Asn Ala Ala Leu 
225                 230                 235                 240 


Glu Glu Val Leu Met Ala Leu Lys Cys Val Tyr Lys Cys Asp Leu Asn 
                245                 250                 255     


Asn Ile Asp Thr Arg Lys Phe Arg Gly Ile Cys Glu Tyr Val Ala Gln 
            260                 265                 270         


Ala Ser Gly Arg Ile Leu Pro Thr Trp Lys Pro Val Val Gly Asp Asn 
        275                 280                 285             


Met Phe Ile His Glu Ser Gly Ile His Ala Asp Gly Ala Leu Lys Asp 
    290                 295                 300                 


Pro His Asn Tyr Glu Pro Phe Asp Pro Ser Glu Val Asn Leu Glu Arg 
305                 310                 315                 320 


Lys Ile Val Ile Gly Lys His Ser Gly Arg Ala Ala Val Val Asn Lys 
                325                 330                 335     


Leu Ser Glu Tyr Glu Met Tyr Ile Ser Pro Glu Asn Ala Thr Lys Leu 
            340                 345                 350         


Leu Asn Ala Ile Arg Ala Thr Ser Ile Arg Leu Lys Arg Ser Leu Met 
        355                 360                 365             


Asp Lys Glu Ile Leu Gln Leu Tyr Cys Asp Ile Leu Ala His Glu Lys 
    370                 375                 380                 


Gly Thr Thr Glu Glu Glu Ala Val Arg Gly Ser Tyr Ile 
385                 390                 395         


<210>  69
<211>  1191
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  69
atgtgtgtta tcagcaagga tcgtgctaag gagatcaaga tcgtggacac aacactgcgc       60

gacggcgagc agaccgccgg cgtcgtcttc gccaaccgag aaaaaattat gatcgcagaa      120

atgttgtctg acctgggagt tgaccaaatc gaagtgggaa tccccaccat gggcggcgac      180

gagaagaacg tgattaagca catttgctct cgcaatctga agtcggacat catggcatgg      240

aaccgcgcag tcatcaaaga tgtagaggag tccatcagct gcggcgttga cgctgtggca      300

atctccatct ccgtctctga tatccatatc gagaacaaac ttcgcacctc gcgtggttgg      360

gttctggaaa acatggctaa gaccgtggag ttcgctaaga aaaacggtct gtacgtttcc      420

gtgaacggag aagatgcaag ccgcgcagat atcgattttc tgaccgaatt tatcaacgta      480

ggtaagcagg ccggagccga ccgcttccgc tactgcgata ccgtcggcgt gatgaacccc      540

ttttccatta agaacgcaat cgagacgctc tacgagcgca caaacttcga cattgagatg      600

catacccaca atgacttcgg catggccacc gcaaatgcgc tggcgggaat cgccgccggc      660

gcaaattacg ttggcgtgac agtcaacggc ctgggcgaac gtgccggcaa cgcagccctc      720

gaagaagtac tgatggcgct taagtgtgtt tacaaatgcg atctcaataa cattgatacg      780

cgcaagttcc gtggtatctg cgaatacgta gctcaagcat ccggccgcat cctgcccacc      840

tggaaacctg ttgtcggaga caacatgttc atccacgaaa gcggcattca tgccgatgga      900

gcgctgaagg atcctcacaa ttatgaaccg ttcgacccgt ccgaggtcaa ccttgagcga      960

aaaatcgtca tcggcaagca ctcaggacgt gccgccgtcg tcaataagct ttccgagtac     1020

gagatgtaca tctcccctga gaacgcaacc aagctgctca acgctatccg tgcaaccagc     1080

atccgactga agcgttcgct tatggacaag gaaatcctgc agctctactg tgacatcttg     1140

gctcacgaaa agggtaccac cgaggaagaa gcggtacgcg gctcctacat t              1191


<210>  70
<211>  527
<212>  PRT
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  70

Met Ala Ala Asp Gln Leu Val Lys Thr Glu Val Thr Lys Lys Ser Phe 
1               5                   10                  15      


Thr Ala Pro Val Gln Lys Ala Ser Thr Pro Val Leu Thr Asn Lys Thr 
            20                  25                  30          


Val Ile Ser Gly Ser Lys Val Lys Ser Leu Ser Ser Ala Gln Ser Ser 
        35                  40                  45              


Ser Ser Gly Pro Ser Ser Ser Ser Glu Glu Asp Asp Ser Arg Asp Ile 
    50                  55                  60                  


Glu Ser Leu Asp Lys Lys Ile Arg Pro Leu Glu Glu Leu Glu Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Gly Asn Thr Lys Gln Leu Lys Asn Lys Glu Val Ala Ala 
                85                  90                  95      


Leu Val Ile His Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Lys Leu 
            100                 105                 110         


Gly Asp Thr Thr Arg Ala Val Ala Val Arg Arg Lys Ala Leu Ser Ile 
        115                 120                 125             


Leu Ala Glu Ala Pro Val Leu Ala Ser Asp Arg Leu Pro Tyr Lys Asn 
    130                 135                 140                 


Tyr Asp Tyr Asp Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly 
145                 150                 155                 160 


Tyr Met Pro Leu Pro Val Gly Val Ile Gly Pro Leu Val Ile Asp Gly 
                165                 170                 175     


Thr Ser Tyr His Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala 
            180                 185                 190         


Ser Ala Met Arg Gly Cys Lys Ala Ile Asn Ala Gly Gly Gly Ala Thr 
        195                 200                 205             


Thr Val Leu Thr Lys Asp Gly Met Thr Arg Gly Pro Val Val Arg Phe 
    210                 215                 220                 


Pro Thr Leu Lys Arg Ser Gly Ala Cys Lys Ile Trp Leu Asp Ser Glu 
225                 230                 235                 240 


Glu Gly Gln Asn Ala Ile Lys Lys Ala Phe Asn Ser Thr Ser Arg Phe 
                245                 250                 255     


Ala Arg Leu Gln His Ile Gln Thr Cys Leu Ala Gly Asp Leu Leu Phe 
            260                 265                 270         


Met Arg Phe Arg Thr Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile 
        275                 280                 285             


Ser Lys Gly Val Glu Tyr Ser Leu Lys Gln Met Val Glu Glu Tyr Gly 
    290                 295                 300                 


Trp Glu Asp Met Glu Val Val Ser Val Ser Gly Asn Tyr Cys Thr Asp 
305                 310                 315                 320 


Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val 
                325                 330                 335     


Val Ala Glu Ala Thr Ile Pro Gly Asp Val Val Arg Lys Val Leu Lys 
            340                 345                 350         


Ser Asp Val Ser Ala Leu Val Glu Leu Asn Ile Ala Lys Asn Leu Val 
        355                 360                 365             


Gly Ser Ala Met Ala Gly Ser Val Gly Gly Phe Asn Ala His Ala Ala 
    370                 375                 380                 


Asn Leu Val Thr Ala Val Phe Leu Ala Leu Gly Gln Asp Pro Ala Gln 
385                 390                 395                 400 


Asn Val Glu Ser Ser Asn Cys Ile Thr Leu Met Lys Glu Val Asp Gly 
                405                 410                 415     


Asp Leu Arg Ile Ser Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile 
            420                 425                 430         


Gly Gly Gly Thr Val Leu Glu Pro Gln Gly Ala Met Leu Asp Leu Leu 
        435                 440                 445             


Gly Val Arg Gly Pro His Ala Thr Ala Pro Gly Thr Asn Ala Arg Gln 
    450                 455                 460                 


Leu Ala Arg Ile Val Ala Cys Ala Val Leu Ala Gly Glu Leu Ser Leu 
465                 470                 475                 480 


Cys Ala Ala Leu Ala Ala Gly His Leu Val Gln Ser His Met Thr His 
                485                 490                 495     


Asn Arg Lys Pro Ala Glu Pro Thr Lys Pro Asn Asn Leu Asp Ala Thr 
            500                 505                 510         


Asp Ile Asn Arg Leu Lys Asp Gly Ser Val Thr Cys Ile Lys Ser 
        515                 520                 525         


<210>  71
<211>  1581
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  71
atggcggctg atcagctcgt taaaacggaa gtaacaaaga aatccttcac cgctcccgta       60

cagaaagctt ctactcctgt cttgaccaac aagaccgtta tctccggctc taaagtgaaa      120

tcgctctctt ccgcccagag cagctcatcc ggtccgtcgt cttcctccga agaggacgac      180

tcacgtgata ttgaatcact ggataaaaag attcgaccgc tcgaagagct tgaggcgctt      240

ttgagctccg gcaataccaa acagttgaag aacaaggagg ttgccgccct tgtgattcac      300

ggcaaacttc cgctctatgc cttggagaag aagttgggag acaccacgcg cgcagtggcc      360

gtgcgccgca aggcactgtc tattctcgcg gaggcacccg tcctggcttc cgaccgcttg      420

ccctacaaga actacgatta cgaccgtgtc ttcggcgcat gttgcgagaa tgtaatcgga      480

tatatgcccc ttcccgttgg cgtgatcggc ccacttgtca tcgatggcac atcataccat      540

attccaatgg cgaccaccga gggttgcctc gtggcgtcgg ccatgcgcgg ttgtaaggcc      600

atcaacgccg gaggtggagc aactaccgta cttactaagg acggcatgac tcgtggcccc      660

gtggtgcgtt tcccgactct taaacgctcc ggtgcgtgca agatctggtt ggattccgag      720

gagggacaga acgcaatcaa aaaagctttc aacagcactt ctcgcttcgc tcgacttcag      780

cacattcaga cctgtctcgc tggtgacttg ttgttcatgc gttttcgcac caccactgga      840

gacgcgatgg gcatgaatat gattagcaaa ggagtggaat actccctcaa acaaatggtg      900

gaagaatatg gctgggaaga catggaagtg gtttccgtgt ctggtaatta ttgtaccgac      960

aagaagccgg cagccatcaa ctggattgag ggccgtggca agtccgtggt ggcggaggcg     1020

acaattccgg gtgatgtcgt gcgcaaagtt ctcaagtctg acgtgtcagc gttggtagaa     1080

ctgaacatcg caaaaaacct tgtaggatcg gcaatggctg gttcagtggg cggttttaat     1140

gcgcacgcag ccaacctcgt caccgctgtg ttccttgccc tgggtcagga tccagcacag     1200

aatgtggaaa gctcgaactg catcaccctg atgaaagaag tggatggcga cttgcgtatc     1260

tccgtctcga tgccatcaat cgaagtgggt accatcggtg gcggaaccgt gttggaacca     1320

cagggagcaa tgcttgatct cctcggcgtt cgaggtccgc acgccacggc gcccggcacc     1380

aacgcacgtc agctggcacg catcgtggct tgcgcggttc tcgcgggtga attgagcctc     1440

tgcgcagccc tggcagcggg tcacctggtg caatctcaca tgacacataa ccgtaaacca     1500

gccgagccca ccaagccgaa taacctcgac gccactgata ttaaccgctt gaaggatggt     1560

tccgtcacct gcatcaaatc t                                               1581


<210>  72
<211>  2052
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  72
atgtttcact cctcccgagc ttggctcaag ggacaaaacc tgacagagaa aatcgtccag       60

tcttacgcag tcaatctccc tgaaggcaag gtcgtccact cgggtgacta cgtgtcgatc      120

aagcccgccc attgtatgtc ccacgataac tcctggccag tggccctcaa gttcatggga      180

ctgggtgcaa ccaagatcaa gaacccctcc cagattgtga ctaccctcga tcatgacatc      240

cagaacaagt ccgagaagaa cctcacaaag tacaagaata ttgaaaactt cgctaagaaa      300

caccacatcg atcactaccc agccggccga ggaattggcc accagattat gatcgaggag      360

ggctatgcct ttcccctgaa catgaccgtg gccagcgact cccactccaa cacctacggc      420

ggactgggta gcctgggtac acccatcgtg cgaacggacg ccgccgctat ttgggctacc      480

ggccaaacgt ggtggcagat tccacccgtc gcccaggtgg agctgaaggg acagctgccc      540

cagggagtgt cgggtaaaga catcattgtt gcactctgcg gcctctttaa caacgaccag      600

gtcctcaatc acgccattga attcacggga gactccctga atgccctgcc catcgaccat      660

agactcacca tcgccaacat gacaaccgag tggggtgccc tgtctggact tttccccgtt      720

gacaagacac ttatcgactg gtacaagaac cgactccaga agctcggaac taataaccat      780

ccccgaatca accccaagac cattcgtgct cttgaggaga aagccaagat ccccaaggcc      840

gacaaggacg cccactacgc caagaagctt attatcgacc ttgccactct tacccactat      900

gtctccggtc ctaactcggt gaaagtttcg aacaccgttc aggatctgtc ccaacaagat      960

attaaaatta acaaggctta cctcgtgtct tgcaccaatt cccgactctc tgacctccag     1020

tctgctgcag acgtcgtctg ccctaccggt gacctcaaca aagttaacaa ggtcgctccc     1080

ggagtcgagt tttacgtggc agccgcttcc tccgagattg aagcagatgc tagaaagagc     1140

ggagcttggg agaagctcct gaaggctggc tgcattcccc ttccctccgg ctgcggtcct     1200

tgcatcggcc tgggtgccgg cctcctcgag cccggtgagg ttggtatctc tgctacgaat     1260

agaaacttca agggaagaat gggctctaag gacgccctcg cttacctcgc ctcgcccgcc     1320

gtggttgctg cttctgccgt cctgggcaag atctccagcc ctgccgaggt gctgtccact     1380

tccgagatcc ctttttcggg cgtcaagact gagatcatcg agaaccccgt cgtggaggag     1440

gaggtcaacg cacagactga ggcccccaaa cagtccgtgg agatccttga gggcttcccc     1500

cgagagtttt ccggcgagct cgttctctgc gacgctgaca atatcaacac tgacggcatc     1560

taccctggca agtacaccta ccaagacgac gtccccaagg agaagatggc ccaggtctgt     1620

atggaaaact acgacgcaga gttccggact aaagtccacc ccggcgacat cgtggttagc     1680

ggattcaact tcggtaccgg ctcctctcga gagcaggccg ccacagccct cctggctaaa     1740

ggcatcaacc tggtcgtgtc cggatccttc ggcaacatct ttagccgaaa ctccattaac     1800

aacgctctcc ttacactcga gattcctgcc ctcattaaga agctgcgtga aaagtaccag     1860

ggcgctccta aggagcttac gcgacgaacc ggatggtttc tcaagtggga tgtcgctgat     1920

gctaaggtcg tggtcacgga aggatcgctg gacggtcccg tgatcctcga gcagaaggtt     1980

ggtgaactgg gcaagaacct ccaggagatc atcgtgaagg gaggacttga aggttgggtg     2040

aagtcccagc tg                                                         2052


<210>  73
<211>  679
<212>  PRT
<213>  Ogataea parapolymorpha

<400>  73

Met Ser Arg His Phe Ser Thr Ser Leu Ala Arg Cys Arg Gly Gln Asn 
1               5                   10                  15      


Leu Thr Glu Lys Ile Val Gln Lys Tyr Ala Val Gly Leu Ala Pro Asp 
            20                  25                  30          


Lys Leu Val Tyr Ser Gly Asp Tyr Val Ser Ile Arg Pro Ala His Val 
        35                  40                  45              


Met Ser His Asp Asn Ser Trp Pro Val Ala Leu Lys Phe Lys Gly Leu 
    50                  55                  60                  


Gly Ala Lys Lys Val Lys Asp Asn Arg Gln Ile Val Asn Thr Leu Asp 
65                  70                  75                  80  


His Asp Val Gln Asn Lys Thr Glu Lys Asn Leu Ala Lys Tyr His Asn 
                85                  90                  95      


Ile Glu Gln Phe Ala Lys Glu Gln Gly Ile Asp Phe Tyr Pro Ala Gly 
            100                 105                 110         


Arg Gly Ile Gly His Gln Ile Met Ile Glu Glu Gly Tyr Ala Phe Pro 
        115                 120                 125             


Ser Asn Leu Thr Val Ala Ser Asp Ser His Ser Asn Thr Tyr Gly Gly 
    130                 135                 140                 


Ile Gly Ser Leu Gly Thr Pro Ile Val Arg Thr Asp Ala Ala Ser Ile 
145                 150                 155                 160 


Trp Ala Thr Gly Gln Thr Trp Trp Gln Ile Pro Pro Val Ala Lys Val 
                165                 170                 175     


Glu Leu Lys Gly Ser Leu Pro Lys Gly Val Thr Gly Lys Asp Val Ile 
            180                 185                 190         


Val Ser Leu Cys Gly Leu Phe Asn Asn Asp Glu Val Leu Asn His Ala 
        195                 200                 205             


Ile Glu Phe Val Gly Asp Glu Ile His Lys Leu Pro Ile Asp Tyr Arg 
    210                 215                 220                 


Leu Thr Ile Ala Asn Met Thr Thr Glu Trp Gly Ala Leu Ser Gly Leu 
225                 230                 235                 240 


Phe Pro Ile Asp Glu Thr Leu Ile Asn Phe Tyr Thr Asn Arg Leu Leu 
                245                 250                 255     


Arg Leu Gly Pro Asn His Pro Arg Ile Asn His Glu Thr Val Glu Lys 
            260                 265                 270         


Leu Arg Gln Asn Lys Leu Ala Ala Asp Pro Asp Ala Tyr Tyr Ala Lys 
        275                 280                 285             


Thr Leu Thr Ile Asp Leu Ser Thr Leu Ser Pro Tyr Ile Ser Gly Pro 
    290                 295                 300                 


Asn Ser Val Lys Val Ser Asn Ser Leu Ser Asp Leu Ser Ala Lys Asn 
305                 310                 315                 320 


Met Lys Val Asp Lys Ala Tyr Leu Val Ser Cys Thr Asn Ser Arg Leu 
                325                 330                 335     


Ser Asp Ile Lys Ala Ala Ala Asp Ile Val Arg Gly His Lys Ile Ala 
            340                 345                 350         


Pro Gly Val Lys Phe Tyr Ile Ala Ala Ala Ser Ser Glu Val Gln Ala 
        355                 360                 365             


Asp Ala Glu Ala Ala Gly Ala Trp Gln Thr Leu Leu Asp Ala Gly Cys 
    370                 375                 380                 


Ile Pro Leu Pro Ala Gly Cys Gly Pro Cys Ile Gly Leu Gly Thr Gly 
385                 390                 395                 400 


Leu Leu Glu Glu Gly Glu Val Gly Ile Ser Ala Thr Asn Arg Asn Phe 
                405                 410                 415     


Lys Gly Arg Met Gly Ser Lys Asp Ala Leu Ala Phe Leu Ala Ser Pro 
            420                 425                 430         


Glu Val Val Ala Ala Ser Ala Val Val Gly Lys Ile Ala Ala Pro Glu 
        435                 440                 445             


Glu Val Asp Gly Lys Pro Cys Pro Pro Thr Arg Glu Val Lys Lys Thr 
    450                 455                 460                 


Ile Val Val Asn Glu Lys Pro Pro Ser Thr Asp Asp Thr Ala Lys Ser 
465                 470                 475                 480 


Ser Gly Ser Val Leu Pro Gly Phe Pro Glu Glu Ile Thr Gly Glu Leu 
                485                 490                 495     


Val Leu Cys Asp Ala Asp Asn Ile Asn Thr Asp Gly Ile Tyr Pro Gly 
            500                 505                 510         


Lys Tyr Thr Tyr Gln Asp Asp Val Pro Arg Glu Lys Met Ala Glu Val 
        515                 520                 525             


Cys Met Glu Asn Tyr Asp Ser Glu Phe Gly Lys Lys Thr Lys Ala Gly 
    530                 535                 540                 


Asp Ile Ile Ile Ser Gly Phe Asn Phe Gly Thr Gly Ser Ser Arg Glu 
545                 550                 555                 560 


Gln Ala Ala Thr Cys Ile Leu Ala Arg Asp Ile Lys Leu Val Val Ala 
                565                 570                 575     


Gly Ser Phe Gly Asn Ile Phe Ser Arg Asn Ser Ile Asn Asn Ala Leu 
            580                 585                 590         


Leu Thr Leu Glu Ile Pro Asp Leu Ile Asn Met Leu Arg Asp Arg Tyr 
        595                 600                 605             


Arg Asp Ser Glu Pro Glu Leu Thr Arg Arg Thr Gly Trp Phe Leu Lys 
    610                 615                 620                 


Trp Asn Val Pro Lys Ser Leu Val Thr Val Thr Asp Ser Ser Gly Ala 
625                 630                 635                 640 


Val Val Leu Glu Gln Lys Val Gly Glu Leu Gly Thr Asn Leu Gln Glu 
                645                 650                 655     


Ile Ile Ile Gln Gly Gly Leu Glu Gly Trp Val Arg Ser Glu Leu Gln 
            660                 665                 670         


Lys Glu Ala Gln Gln Gln Gln 
        675                 


<210>  74
<211>  2037
<212>  DNA
<213>  Ogataea parapolymorpha

<400>  74
atgagccgcc attttagcac ttcactggcg cgctgtcgtg gccagaacct caccgaaaag       60

attgtgcaga aatacgcggt tggcctggca ccggataagc tcgtatactc aggcgactac      120

gtatctatcc gcccagctca cgtaatgtcg catgataata gctggcccgt ggctcttaaa      180

tttaagggtc tgggtgcgaa aaaggtgaag gacaaccgtc aaatcgtcaa tacccttgac      240

cacgacgttc agaacaagac tgagaagaac ctggcaaaat accacaacat tgaacaattc      300

gcgaaggagc agggcattga cttttacccc gcaggacggg gaatcggcca tcagattatg      360

atcgaggaag gctacgcttt tccaagcaat ctcactgttg cttccgattc gcactccaat      420

acctatggag gcattggctc tcttggcacc ccgattgtcc gtacggatgc tgcctctatt      480

tgggcgaccg gccagacgtg gtggcaaatc ccacctgtgg ctaaggtcga gttgaaggga      540

tctttgccaa agggcgtaac gggcaaggac gtaatcgtgt ccctctgcgg tctctttaac      600

aatgatgagg tattgaacca cgcaatcgag ttcgtcggcg atgagatcca taaactgccg      660

attgattacc ggctcacgat cgcaaacatg acgactgaat ggggcgcctt gtctggtttg      720

ttccccattg acgagactct gattaatttt tatacgaacc gcctccttcg cttgggtcca      780

aatcacccac ggattaatca cgaaaccgta gaaaagctcc gccagaataa gcttgctgca      840

gaccccgacg catattacgc aaaaactctt actattgacc tctccaccct ttctccatat      900

atttccggtc cgaactctgt caaagtgagc aacagcctca gcgacctgtc ggcaaaaaat      960

atgaaagttg acaaggccta tctggtgtcc tgcaccaatt cgcgcctttc tgacattaaa     1020

gcggcagccg atatcgtgcg tggccataag atcgccccgg gtgtaaagtt ctatatcgcg     1080

gccgcatcgt ccgaagtgca agccgatgcg gaggcggctg gagcctggca aactctcctg     1140

gacgctggtt gcattccgct tcccgcggga tgcggtcctt gtatcggact cggaacgggc     1200

ctcttggagg agggcgaagt cggtattagc gccacgaatc gcaacttcaa aggtcgcatg     1260

ggatccaaag acgccctcgc ttttttggcg tccccagagg tcgtagcagc tagcgcggtc     1320

gtcggcaaga tcgcagcacc cgaagaggta gatggaaagc catgccctcc aacccgcgaa     1380

gtaaagaaaa cgattgtcgt caacgagaaa cccccatcaa cggatgacac ggctaaaagc     1440

tctggctctg tgttgccagg attccccgaa gagatcactg gagagttggt cctgtgtgac     1500

gcggacaata ttaataccga cggtatttat cctggaaaat atacgtatca ggacgatgtc     1560

ccccgcgaaa agatggccga ggtgtgcatg gaaaattatg actcagagtt tggtaagaaa     1620

accaaggctg gcgatatcat catttccggc tttaatttcg gtacgggttc tagccgtgaa     1680

caggcggcta cttgtatttt ggcgcgggat attaaacttg tggtggccgg atcctttgga     1740

aacatttttt cccggaactc aatcaataac gctctgctga cgctcgaaat tccagacctt     1800

atcaatatgc tgcgcgatcg ctaccgtgat tcggaaccgg agctgactcg ccgcactggc     1860

tggtttttga aatggaatgt ccccaaatca ctggttactg tcacggattc gtcgggcgcg     1920

gtggttttgg agcagaaggt tggtgagttg ggcactaatc tccaagaaat tatcatccag     1980

ggtggtctcg agggctgggt tcgctcagag cttcagaagg aggcacagca acaacaa        2037


<210>  75
<211>  2052
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  75
atgtttcact cttcccgtgc gtggctcaaa ggacagaatc tgaccgaaaa gattgtgcag       60

tcatatgctg tcaatctccc tgaaggcaag gtggtccact cgggcgatta cgtgtcgatt      120

aagccggctc actgcatgtc tcatgataat tcttggcccg tagcactcaa atttatggga      180

ctgggcgcca ccaagatcaa aaatccgtct cagattgtga ccaccctgga ccatgatatc      240

caaaacaaat ccgaaaaaaa tctgactaag tacaagaaca ttgaaaactt cgctaaaaaa      300

caccacatcg atcactaccc tgcgggccgc ggtatcggcc accaaattat gatcgaggaa      360

ggttatgcct ttcctctcaa catgaccgtg gcatcagact cccactcaaa cacgtatggt      420

ggtctgggct cgctcggcac tccgattgtc cgcactgatg cagctgccat ctgggctacg      480

ggtcagacct ggtggcagat cccccctgtg gcccaggttg aactgaaggg ccagcttccc      540

cagggtgtgt ccggcaagga catcatcgta gccctttgcg gtctctttaa caacgaccag      600

gttttgaacc acgcgattga gttcaccggc gattcgctga acgcgcttcc tattgatcat      660

cgccttacca tcgcgaacat gaccacagaa tggggtgccc tctccggcct ctttcctgtc      720

gataaaacct tgatcgattg gtacaaaaat cgtctccaga agttgggaac caataaccat      780

ccgcgtatca acccgaaaac cattcgagca ttggaagaga aggccaaaat ccccaaggct      840

gacaaggatg ctcattacgc taagaagttg atcatcgacc tcgccaccct tacccactac      900

gtgtcgggac ctaattctgt taaggtgtcc aacactgtgc aggacctgag ccagcaagat      960

attaaaatca acaaagctta tttggtttct tgcacaaatt cgcgcctgtc cgatttgcag     1020

tccgcggccg acgttgtctg tccaaccggt gacttgaaca aggttaacaa ggttgcacca     1080

ggcgttgaat tctacgtcgc ggcagcatcc agcgaaatcg aagccgatgc gcgcaaatcc     1140

ggtgcttggg aaaagctgct gaaggcaggc tgcatccccc tgccgtctgg atgcggccct     1200

tgcatcggct tgggcgcagg cttgttggaa ccgggcgagg tgggcatctc cgcgactaat     1260

cgcaacttta agggacgcat gggttcgaag gacgcgcttg catacttggc gtctcctgca     1320

gtcgtagcgg catccgctgt tctcggaaag atcagctcgc ccgctgaggt cttgagcacc     1380

tctgaaattc ctttctccgg cgtgaaaacc gaaatcatcg aaaaccctgt tgtggaagag     1440

gaagtgaacg cgcagaccga agcgcctaaa caatccgttg aaatcctcga gggttttcca     1500

cgcgaattct ctggcgaact tgtgctgtgc gacgctgata acatcaacac cgatggtatc     1560

tacccgggta aatatacgta ccaagacgac gtcccaaaag aaaaaatggc tcaggtttgc     1620

atggagaatt atgacgccga gtttcgcacc aaggtccacc ctggagatat tgttgtcagc     1680

ggtttcaatt tcggtaccgg ttcaagccgc gagcaggccg caacagcact tctggccaag     1740

ggtattaact tggttgtatc tggcagcttc ggtaatattt tctcacgaaa ctcaatcaat     1800

aacgcactgc ttaccctcga gatcccagcg cttattaaga agcttcgtga gaaataccaa     1860

ggagctccca aggaattgac gcgccgcaca ggttggtttc ttaaatggga tgtagcagat     1920

gcgaaggtgg tggttaccga gggtagcctg gacggcccag tgatccttga acaaaaggtg     1980

ggcgaacttg gcaagaacct tcaggaaatt attgttaaag gcggcctcga aggctgggtt     2040

aagtctcaac tg                                                         2052


<210>  76
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  76
atgtcaatca agaatctaaa taacggcaaa gaggtcttta tcgtagacac cacattgaga       60

gatggtgagc aaaccgccgg tgttgttttt gctaatgagg agaaaatcgc aattgccagt      120

atgttatctg aactgggtgt tgatcagtta gaagtgggaa tcccaaccat gggtggtgat      180

gagaaagaag ctattaaaca gattgtgaag aggaaccaga aatcttcaat catggcctgg      240

aatagagctg tcattaagga tattgaagaa tcaatagatt gcggggtcga cgctgtggcc      300

attagcataa gtgtgtcaga tatacatatc cagcataaat tgaaaacgtc tagagggtgg      360

gttttggaaa atatggtaaa atcagtcgaa tttgctaaga aaaacggatt gtacgtatca      420

gtaaatggtg aggatgctag tagagccgat agagagtttc ttatccaatt tatcgaagta      480

gctaaacaag cgggagcaga ccgtttccgt tactgcgata ccgttggtat tatggagcca      540

ttcaaaatta atgaggatat tagataccta catgcgaaga ccaattttga tatcgaaatg      600

catacacaca acgattttgg tatggcgaca gccaacgcaa ttgcgggaat tatgggtggc      660

gcttctcacg tgggcgtgac agtaaacgga ctgggtgaac gtgctggtaa cgctgcctta      720

gaagaggtac ttatggcgct gatgttcgtt tacaattacg gtggcaatat ctctacaaca      780

atgttcagag aagtatctga atatgtcagt agagcatcag gccgtatttt gccagcatgg      840

aaagctatag tcggagataa catgttcgct cacgaatcag gcatacatgc cgatggtgcc      900

atcaaaaatc ctaaaaatta tgaggctttc gatccaggta tcgttggatt agaaagacaa      960

attgtaatcg gcaaacactc cggtaaagcg ggcatcatca acaaatttaa ggaatacgga     1020

atcgacctgg acaacaattc tgctaaagat attttggaga tggtgcgttc tacttcagta     1080

agactaaaaa gatcactgtt cgataaagag cttgtccaga tctataagga atacttaaga     1140

ttgagggaag aaaaagtcaa c                                               1161


<210>  77
<211>  1284
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  77
atgacggctg ctaagcccaa tccatacgca gcaaagcccg gcgattacct gagcaacgtg       60

aacaacttcc agctcatcga ttcaaccctc cgtgaaggcg aacaattcgc aaacgccttt      120

tttgataccg agaagaagat cgaaatcgca cgagcactgg atgatttcgg tgtcgattac      180

attgagctga cctctccggt cgcgtctgaa cagtctcgaa aagattgtga agccatctgt      240

aagctcggtc tcaaagctaa aatcctgacc cacattcgct gccacatgga tgatgctaaa      300

gtagcagtgg agactggagt ggacggcgtt gatgttgtca ttggcacctc gaaatttttg      360

cgtcagtact cccacggtaa ggatatgaac tacatcgcaa agtctgcggt cgaggtaatt      420

gaattcgtta aatccaaggg tatcgaaatt cgcttctcaa gcgaagattc tttccgtagc      480

gatctggtgg atctgctgaa tatctacaag accgtggata aaatcggcgt gaaccgcgtt      540

ggcatcgccg acaccgtagg ttgtgctaat ccccgccagg tctacgaact gattcgcacg      600

cttaaatccg tagtctcgtg tgatatcgaa tgtcactttc acaatgacac cggctgtgcc      660

atcgcgaacg cctacaccgc actggagggt ggcgctcgct tgattgacgt ctcggttctg      720

ggcatcggtg agcgcaatgg tattacccca ctcggtggtc tcatggcccg tatgatcgtc      780

gctgctcctg actacgttaa gtctaagtac aaattgcaca agattcgcga tatcgagaat      840

cttgtcgcag acgcggtgga agtgaacatc ccctttaaca acccgatcac cggattttgt      900

gctttcaccc ataaggctgg tatccatgcg aaagcaatct tggcgaaccc tagcacctac      960

gagatcttgg atcctcacga tttcggaatg aagcgctaca ttcattttgc taaccgtctg     1020

accggctgga acgctatcaa ggcacgtgtt gaccagctga acctgaactt gactgacgat     1080

cagatcaaag aggtcacagc gaagatcaaa aaactgggtg acgtgcgctc tcttaacatt     1140

gatgacgtgg attccattat taagaacttc cacgccgagg tctccacccc tcaggttctc     1200

tctgcgaaga agaataagaa gaacgactcc gatgtgccag aattggccac catcccagcg     1260

gccaagcgta caaagccgtc cgct                                            1284


<210>  78
<211>  1113
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  78
atgtttcgct cggttgcaac acggttgtca gcttgtagag gtctcgcatc aaacgccgca       60

cgaaagtctt taacgatcgg tttaattcca ggtgacggaa taggcaaaga agttattcca      120

gccggcaagc aggtactgga aaatttaaac agcaaacatg gtttgtcttt taattttatc      180

gatctctatg cggggtttca gacgtttcaa gagacaggta aagcccttcc tgatgagacg      240

gtcaaagttc ttaaagaaca atgccaaggt gccttgtttg gtgcagtaca atcgcctacg      300

acaaaggttg agggctattc aagcccaatt gtagctttac gacgcgaaat gggattattt      360

gctaacgttc ggccggtcaa atctgttgaa ggtgagaaag gcaaacctat agacatggtg      420

attgtccgcg aaaataccga agatttatac atcaaaattg agaaaactta tattgataaa      480

gcgacaggaa cacgagtagc tgacgccaca aaacggatca gcgaaatcgc tacacggcgc      540

attgcaacca tcgctctgga cattgcgctg aagcgattac aaacacgtgg acaggctacg      600

ttgacagtaa cccataagag caatgttctg tcacaatcgg atggcctgtt cagagaaatc      660

tgcaaagaag tgtatgaaag taacaaagat aagtatgggc aaatcaaata caacgaacaa      720

attgttgatt caatggtgta tagactcttt agagagccac agtgctttga tgttatcgtg      780

gccccgaatt tatatgggga tattttatcc gacggagcgg cagccttagt tggctccctg      840

ggtgttgtcc cgtcagctaa cgtcggcccg gaaatcgtaa ttggcgaacc gtgccatggc      900

agtgctccgg atattgccgg taaaggaatt gccaatccta tcgcgacgat tcggtccaca      960

gcgttaatgt tagaattcct gggtcacaat gaagcagcgc aagatattta taaagcggtg     1020

gacgcaaatc tgcgggaggg aagcattaaa acgcctgatc tgggcggtaa agccagcact     1080

cagcaggtgg ttgacgacgt actttcaaga tta                                  1113


<210>  79
<211>  1113
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  79
atgtttcgtt ctgttgccac tcggctgtcc gcctgccgag gactcgcctc taacgctgcc       60

agaaagtctc tgaccatcgg actcattccc ggtgatggaa ttggaaagga agtgatccct      120

gctggaaagc aggtcctgga gaaccttaac tccaaacacg gcctgtcctt caacttcatc      180

gatctctacg ccggctttca gaccttccag gagaccggaa aggcacttcc agacgagaca      240

gttaaagtcc tgaaggagca atgccagggc gctctcttcg gtgctgttca gtctcccact      300

acgaaggtgg agggatacag ctcccctatt gtggcccttc ggcgagagat gggactgttc      360

gcaaacgtgc ggcccgtcaa atccgtcgaa ggtgaaaagg gcaagcccat cgacatggtg      420

atcgtccggg agaacactga ggacctttac atcaagatcg agaagactta catcgataag      480

gccactggca cccgagtcgc tgacgctact aagcgaatct cggaaattgc cacccgacga      540

atcgccacga tcgcacttga catcgccctc aagcgactcc agacccgggg tcaagccacg      600

ctgacagtga cccacaaatc taacgtgctc tcccagtcgg acggactctt ccgagagatt      660

tgcaaggagg tgtatgaatc gaacaaggat aaatacggcc agatcaagta taacgaacag      720

atcgttgact ccatggtcta ccgactgttc cgagagcctc agtgctttga cgtcatcgtt      780

gcccctaacc tctacggcga catcctctcg gacggagccg ctgctctggt cggctctctg      840

ggtgtcgtgc cttctgccaa cgtgggtccc gagattgtca ttggagagcc atgccacggt      900

tctgcccctg atattgcagg aaagggaatc gctaacccca tcgccactat tcgaagcaca      960

gctctcatgc ttgagttcct cggccacaac gaggccgccc aggacattta caaggccgtc     1020

gacgccaacc tccgagaggg aagcatcaag accccagacc tgggtggcaa ggcctccacc     1080

cagcaagtgg tggacgacgt cctttcgcgg ctg                                  1113


<210>  80
<211>  1284
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  80
atgactgccg ctaagcctaa cccttacgcc gccaagcccg gcgactacct gtctaacgtg       60

aacaattttc agcttatcga tagcaccctc cgagagggag aacagttcgc caacgccttc      120

tttgataccg agaagaagat tgaaatcgcc cgagccctgg acgattttgg cgtcgactac      180

atcgaactga catctcccgt tgcttcggag cagtcgcgga aggattgcga ggctatttgc      240

aagctgggtc ttaaggctaa gatcctcacc cacattcgat gtcatatgga cgacgctaag      300

gtggccgtcg agactggtgt ggacggtgtc gacgttgtca tcggcacatc caaatttctt      360

cgacaatatt cccacggcaa agacatgaac tacatcgcca agtctgcagt tgaggtcatt      420

gaatttgtga agagcaaggg tattgaaatt cggttctctt ccgaggactc tttccgttct      480

gatcttgttg acctgctcaa catctacaag actgtggata aaatcggcgt gaacagagtt      540

ggaattgcag acactgttgg ttgtgccaac cctcggcagg tctacgagct catccgtacg      600

ctcaagtctg tcgtgagctg tgacattgag tgtcactttc acaatgatac tggatgcgca      660

atcgccaatg catacactgc tctcgaaggc ggagctcggc tgattgacgt tagcgtgctg      720

ggtattggag agcgtaacgg cattacaccc ctcggcggcc tcatggctcg tatgatcgtc      780

gccgcccctg attacgtcaa gtctaagtac aagctgcaca agattcgaga cattgagaac      840

cttgttgctg acgccgtcga agtgaatatc cctttcaata accctatcac cggtttctgc      900

gcctttaccc acaaggctgg catccacgcc aaggctattc tggctaaccc ctctacctac      960

gagattctcg acccccatga ctttggaatg aaacgataca tccactttgc taaccgactg     1020

accggctgga atgcaattaa ggcccgtgtg gaccagctca acctcaacct tacggacgat     1080

cagatcaaag aggttaccgc caagattaag aagcttggag acgtgcggtc cctcaacatc     1140

gacgacgtgg attcgattat caagaacttc catgctgaag tctctacccc tcaagtcctg     1200

tccgctaaga agaacaagaa gaacgactct gatgtccctg aactcgccac tattcctgct     1260

gctaaaagaa ctaagccttc cgca                                            1284


<210>  81
<211>  1113
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  81
atgtttagaa gcgttgctac taggctatct gcctgtaggg gactagcttc aaacgctgca       60

agaaaaagct tgactattgg tttgatacca ggtgatggta taggaaagga agtaatcccg      120

gctggaaagc aagttttgga aaacttaaat tctaaacacg gtttgtcatt taatttcata      180

gacttgtatg ctggcttcca aactttccaa gaaacaggaa aggccttgcc agacgaaaca      240

gtcaaagtct taaaggagca atgccagggt gctctttttg gcgcagtaca gtctcctacc      300

accaaagtag agggttattc ttctccaata gttgccttga gaagggaaat gggccttttt      360

gcaaacgtta ggcctgtaaa atccgtcgag ggtgaaaaag gtaagccaat tgatatggtt      420

attgttagag aaaacaccga ggatttgtat attaagatag aaaagaccta tatagacaaa      480

gccaccggaa ccagagttgc agatgcaact aaaagaattt ccgagattgc gacgagaagg      540

atagctacca ttgccctaga tattgcccta aagagattgc aaactagggg gcaagctacg      600

ttaacagtca cacacaaaag caatgtgctg tcccaatctg atggtttgtt ccgtgaaata      660

tgcaaggaag tatacgaaag caataaagat aagtatggtc agataaagta taacgaacaa      720

atcgtcgatt caatggtata taggctgttt agagaacctc agtgctttga tgtaattgtt      780

gcccctaact tgtatggtga catcctatcc gatggcgctg cggctctagt aggttccttg      840

ggtgtggtcc catcagctaa cgttggacca gaaattgtca ttggtgagcc atgccatggc      900

agtgcgccgg atatcgcggg taagggtatc gcgaacccca tcgccaccat tagaagtaca      960

gcattaatgc ttgaattcct aggccacaat gaggcagcac aggatatcta taaggcagtc     1020

gacgccaatc ttcgtgaagg ttctattaaa acaccagatt tgggtggcaa ggcgtctaca     1080

caacaggtcg ttgacgacgt tttatcaaga ctt                                  1113


<210>  82
<211>  2079
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  82
atgcttcgat ccacaacttt cacccgttct tttcactctt cccgagcttg gctcaagggt       60

cagaacctga ctgagaagat tgtccagagc tacgccgtga acctgcctga gggcaaagtg      120

gtccactccg gtgactacgt ttccatcaag cccgcacact gtatgtctca cgataactcc      180

tggcctgttg ctcttaagtt catgggtctc ggagctacta agattaaaaa cccttcgcag      240

attgtcacca cactcgatca cgacatccag aacaagtctg aaaagaacct taccaagtac      300

aagaatatcg aaaatttcgc caaaaagcac cacattgatc actaccccgc tggtcgaggt      360

attggtcatc agattatgat cgaggaggga tacgccttcc cccttaacat gaccgttgct      420

agcgactccc actctaatac ttatggcgga ctgggatcgc tgggtactcc catcgtgcga      480

accgatgccg ctgctatttg ggctacgggc caaacttggt ggcagatccc tccagtggca      540

caggtggagc tcaagggcca gctcccccaa ggcgtgagcg gaaaggacat tatcgtcgcc      600

ctgtgcggcc tgttcaacaa cgaccaggtg ctgaaccacg ctattgagtt cactggcgac      660

tccctgaacg cactccccat tgatcatcga cttaccatcg ctaacatgac taccgagtgg      720

ggtgcactgt ccggcctctt ccccgttgac aagaccctga ttgattggta taagaaccga      780

ctccagaagc tgggtaccaa caaccacccc cgtattaacc ccaagaccat ccgagccctg      840

gaggagaagg ccaagattcc caaggctgac aaggacgctc actacgccaa gaagctcatc      900

attgaccttg ctaccctgac gcactacgtc tccggtccaa actccgtcaa ggtctcgaat      960

actgtccaag atcttagcca acaggacatt aagatcaaca aggcttatct ggtgtcgtgt     1020

accaactccc gactctctga tctgcagtct gcagctgatg tggtctgccc cacgggtgac     1080

cttaataagg tcaacaaggt ggcaccaggt gtggagttct acgtcgccgc agcttcctcc     1140

gagattgagg ctgacgccag aaaaagcggt gcttgggaga aacttctgaa ggccggttgc     1200

atccctcttc cctctggctg cggcccttgc atcggtctcg gcgctggtct cctggagccc     1260

ggtgaggtcg gaatttccgc aacaaaccga aacttcaagg gacgaatggg cagcaaggac     1320

gccctggctt acctggccag ccccgctgtt gtggccgcct ccgccgtcct gggtaagatc     1380

agctcccccg ctgaggtgct cagcacttcc gaaatcccat tttccggtgt taagaccgag     1440

atcattgaaa accccgtggt cgaggaggaa gttaacgcac aaaccgaagc tcctaaacag     1500

tctgtcgaga tcctggaagg ttttccccga gaattttcgg gcgagctcgt cctctgcgac     1560

gctgataaca tcaacaccga tggcatttac cccggtaagt acacctacca agacgacgtc     1620

ccaaaggaga agatggcaca ggtttgtatg gagaactacg atgccgagtt ccgaacgaag     1680

gtccatcctg gagatatcgt ggtttccggt tttaatttcg gaactggctc gtctcgagag     1740

caggccgcca cagcactgct cgccaagggc attaaccttg tcgtctcggg ctcgttcgga     1800

aacatttttt cccggaactc catcaacaac gccctgctga ctcttgagat ccctgccctg     1860

atcaagaagc tgagagagaa gtatcagggc gctcctaagg aacttacacg acgtaccgga     1920

tggtttctta agtgggacgt ggctgacgcc aaggtcgtgg tgaccgaggg atcccttgac     1980

ggaccagtca tcctggaaca gaaggtcggc gagctgggca agaacctcca ggagatcatc     2040

gtcaagggag gtctggaggg ttgggtgaag tctcagctg                            2079


<210>  83
<211>  680
<212>  PRT
<213>  Neosartorya fumigata

<400>  83

Met Phe Ala Thr Thr Ser Leu Arg Arg Tyr Thr Glu Ala Ser Ser Ser 
1               5                   10                  15      


Thr Thr Gln Thr Ser Pro Ser Ser Ser Ser Trp Pro Ala Pro Asp Ala 
            20                  25                  30          


Ala Pro Arg Val Pro Gln Thr Leu Thr Glu Lys Ile Val Gln Ala Tyr 
        35                  40                  45              


Ser Leu Gly Leu Ala Glu Gly Gln Tyr Val Lys Ala Gly Asp Tyr Val 
    50                  55                  60                  


Met Leu Ser Pro His Arg Cys Met Thr His Asp Asn Ser Trp Pro Thr 
65                  70                  75                  80  


Ala Leu Lys Phe Met Ala Ile Gly Ala Ser Lys Val His Asn Pro Asp 
                85                  90                  95      


Gln Ile Val Met Thr Leu Asp His Asp Val Gln Asn Lys Ser Glu Lys 
            100                 105                 110         


Asn Leu Lys Lys Tyr Glu Ser Ile Glu Lys Phe Ala Lys Gln His Gly 
        115                 120                 125             


Ile Asp Phe Tyr Pro Ala Gly His Gly Val Gly His Gln Ile Met Ile 
    130                 135                 140                 


Glu Glu Gly Tyr Ala Phe Pro Gly Thr Val Thr Val Ala Ser Asp Ser 
145                 150                 155                 160 


His Ser Asn Met Tyr Gly Gly Val Gly Cys Leu Gly Thr Pro Met Val 
                165                 170                 175     


Arg Thr Asp Ala Ala Thr Ile Trp Ala Thr Gly Arg Thr Trp Trp Lys 
            180                 185                 190         


Val Pro Pro Ile Ala Lys Val Gln Phe Thr Gly Thr Leu Pro Glu Gly 
        195                 200                 205             


Val Thr Gly Lys Asp Val Ile Val Ala Leu Ser Gly Leu Phe Asn Lys 
    210                 215                 220                 


Asp Glu Val Leu Asn Tyr Ala Ile Glu Phe Thr Gly Ser Glu Glu Thr 
225                 230                 235                 240 


Met Lys Ser Leu Ser Val Asp Thr Arg Leu Thr Ile Ala Asn Met Thr 
                245                 250                 255     


Thr Glu Trp Gly Ala Leu Thr Gly Leu Phe Pro Ile Asp Ser Thr Leu 
            260                 265                 270         


Glu Gln Trp Leu Arg His Lys Ala Ala Thr Ala Ser Arg Thr Glu Thr 
        275                 280                 285             


Ala Arg Arg Phe Ala Glu Glu Arg Ile Asn Glu Leu Phe Ala Asn Pro 
    290                 295                 300                 


Thr Val Ala Asp Arg Gly Ala Arg Tyr Ala Lys Tyr Leu Tyr Leu Asp 
305                 310                 315                 320 


Leu Ser Thr Leu Ser Pro Tyr Val Ser Gly Pro Asn Ser Val Lys Val 
                325                 330                 335     


Ala Thr Pro Leu Asp Glu Leu Glu Lys His Lys Leu Lys Ile Asp Lys 
            340                 345                 350         


Ala Tyr Leu Val Ser Cys Thr Asn Ser Arg Ala Ser Asp Ile Ala Ala 
        355                 360                 365             


Ala Ala Lys Val Phe Lys Asp Ala Val Ala Arg Thr Gly Gly Pro Val 
    370                 375                 380                 


Arg Val Ala Asp Gly Val Glu Phe Tyr Val Ala Ala Ala Ser Lys Ala 
385                 390                 395                 400 


Glu Gln Lys Ile Ala Glu Glu Ala Gly Asp Trp Gln Ala Leu Met Asp 
                405                 410                 415     


Ala Gly Ala Ile Pro Leu Pro Ala Gly Cys Ala Val Cys Ile Gly Leu 
            420                 425                 430         


Gly Ala Gly Leu Leu Lys Glu Gly Glu Val Gly Ile Ser Ala Ser Asn 
        435                 440                 445             


Arg Asn Phe Lys Gly Arg Met Gly Ser Pro Asp Ala Lys Ala Tyr Leu 
    450                 455                 460                 


Ala Ser Pro Glu Val Val Ala Ala Ser Ala Leu Asn Gly Val Ile Ser 
465                 470                 475                 480 


Gly Pro Gly Ile Tyr Lys Arg Pro Glu Asp Trp Thr Gly Val Ser Ile 
                485                 490                 495     


Gly Glu Gly Glu Val Val Glu Ser Gly Ser Arg Ile Asp Thr Thr Leu 
            500                 505                 510         


Glu Ala Met Glu Lys Phe Ile Gly Gln Leu Asp Ser Met Ile Asp Ser 
        515                 520                 525             


Ser Ser Lys Ala Val Met Pro Glu Glu Ser Thr Gly Ser Gly Ala Thr 
    530                 535                 540                 


Glu Val Asp Ile Val Pro Gly Phe Pro Glu Lys Ile Glu Gly Glu Ile 
545                 550                 555                 560 


Leu Phe Leu Asp Ala Asp Asn Ile Ser Thr Asp Gly Ile Tyr Pro Gly 
                565                 570                 575     


Lys Tyr Thr Tyr Gln Asp Asp Val Thr Lys Asp Lys Met Ala Gln Val 
            580                 585                 590         


Cys Met Glu Asn Tyr Asp Pro Ala Phe Ser Gly Ile Ala Arg Ala Gly 
        595                 600                 605             


Asp Ile Phe Val Ser Gly Phe Asn Phe Gly Cys Gly Ser Ser Arg Glu 
    610                 615                 620                 


Gln Ala Ala Thr Ser Ile Leu Ala Lys Gln Leu Pro Leu Val Val Ala 
625                 630                 635                 640 


Gly Ser Ile Gly Asn Thr Phe Ser Arg Asn Ala Val Asn Asn Ala Leu 
                645                 650                 655     


Pro Leu Leu Glu Met Pro Arg Leu Ile Glu Arg Leu Arg Glu Ala Phe 
            660                 665                 670         


Gly Ser Glu Lys Gln Pro Thr Arg 
        675                 680 


<210>  84
<211>  2040
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  84
atgttcgcaa ctacatcttt gcgtagatac accgaagcat cttcttcaac aacgcagacg       60

agcccttctt catcatcatg gccagcacca gatgcggccc caagagtacc tcaaacgtta      120

actgagaaga tcgttcaagc ttattcactg ggtcttgctg aaggtcaata tgttaaagcg      180

ggtgattatg taatgttgtc acctcatagg tgtatgactc atgacaattc ctggccaacc      240

gctttgaaat ttatggcgat cggcgcaagt aaagtgcata atcccgatca aattgttatg      300

acactggatc acgacgttca aaacaaaagc gaaaaaaatc ttaaaaaata cgaatccatt      360

gagaagttcg ctaaacagca tggtattgac ttctatcccg ccggccatgg tgttggtcat      420

caaattatga ttgaagaagg ttacgctttc cctggtaccg tgaccgtggc atctgattca      480

catagcaata tgtatggcgg cgtagggtgc ttggggaccc ctatggtccg tacagacgca      540

gctacgatct gggcaactgg tagaacttgg tggaaggttc cacccattgc aaaggtacag      600

ttcactggca cattaccgga gggtgttact ggaaaagatg ttattgtagc attaagtggt      660

ctattcaata aagacgaagt gttgaattat gcgatcgaat ttactggttc cgaagagacc      720

atgaaatctc tgtctgttga caccagatta accatagcaa atatgacgac ggaatggggc      780

gcattaacag gcttattccc aatcgattct actcttgagc agtggctgag acacaaagca      840

gctacagcct caaggacaga gacggctagg aggtttgcgg aagaaagaat taacgagtta      900

tttgcaaacc ctaccgttgc tgatagagga gccaggtatg ctaaatacct ttatcttgac      960

ttaagtacat tatcacctta cgtgtctggt ccaaactctg ttaaggttgc caccccttta     1020

gatgaactgg agaaacacaa gttaaaaatc gataaagcct atcttgtatc ttgtacgaat     1080

tcaagagcat ctgatatagc ggccgctgcg aaggtattta aagacgctgt tgcaaggact     1140

ggtggacccg taagggttgc tgatggtgtt gagttctatg tagccgccgc ttcaaaagct     1200

gagcaaaaaa ttgcagaaga agcaggggat tggcaagcat tgatggatgc aggtgcaatt     1260

cccttgccgg ctggctgcgc ggtgtgtata ggtttgggtg cgggccttct gaaagagggt     1320

gaagttggta tatcagcttc aaacagaaat ttcaagggca gaatggggtc tccggacgca     1380

aaagcatatt tggctagccc ggaagttgtt gccgcgtcag ccctgaacgg agtgataagc     1440

ggtcctggaa tttataagag acccgaagat tggacgggtg ttagtatcgg ggaaggtgaa     1500

gtagtcgaat ctggttccag aattgatacc actcttgagg caatggagaa attcattggt     1560

caactggatt ccatgattga tagtagctct aaggctgtta tgccggaaga aagcacaggg     1620

tctggcgcaa ctgaggtgga tatcgtacct ggtttccctg aaaaaatcga gggtgagatt     1680

ctttttttag atgctgataa tatcagtacg gacggcattt accccggtaa atatacatac     1740

caggacgacg tcaccaagga caagatggca caagtttgca tggaaaatta cgatccggct     1800

tttagcggca tcgcaagagc tggagacatt tttgttagtg gattcaactt tggatgtgga     1860

tctagtagag agcaggcagc cacatcaatc ttggctaaac agctgccctt ggttgttgct     1920

ggtagtatcg gtaatacatt ctctcgtaac gctgtcaata acgcgttgcc gcttttggag     1980

atgcctagat tgatcgaaag gttgagagag gcatttggtt ccgaaaagca acctaccagg     2040


<210>  85
<211>  2331
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  85
atgtttaagc gcacaggttc gcttctcctc cgttgtcgcg catcccgcgt gccagtcatt       60

ggtcgccctt tgattagctt gtccaccagc agcacgtccc tcagcttgtc tcgaccgcgc      120

tccttcgcaa caacctccct gcgacgctac actgaggcta gctcgtcaac cacgcaaacc      180

agcccatcct ccagctcgtg gccagcacca gacgccgccc cccgcgttcc acaaacactt      240

actgagaaaa tcgttcaggc ttactccctg ggattggccg aaggacaata tgtgaaggcc      300

ggagactatg ttatgttgag cccgcaccgt tgcatgacgc atgataattc ttggcctacc      360

gcactgaagt ttatggctat cggagcgtcg aaagttcaca atcccgatca gattgttatg      420

acactcgatc acgatgttca aaacaaaagc gaaaagaact tgaagaagta cgaatcgatc      480

gagaagttcg ccaagcagca cggcatcgac ttctaccctg cgggccacgg cgttggtcac      540

caaatcatga tcgaagaagg ctacgccttc ccaggtaccg taacagtcgc atctgactct      600

cacagcaata tgtacggcgg tgtgggatgt ctgggtacac caatggtgcg taccgatgca      660

gctacaatct gggcgaccgg ccgtacctgg tggaaggtac cccccattgc gaaagttcag      720

ttcacgggaa cgctgcctga aggcgtaacg ggaaaagatg ttattgtggc actgtcgggt      780

cttttcaaca aggacgaagt cctgaactat gctatcgaat ttacaggttc cgaagagacg      840

atgaagtcgc tgtccgttga tacccgtctc accatcgcga atatgactac tgaatggggc      900

gcgctgaccg gtctcttccc gattgattct acactggaac aatggctgcg ccacaaggct      960

gccactgctt cgcgaaccga aactgcccgc cgtttcgcgg aagagcgaat caacgaactc     1020

tttgcgaatc ccacggtggc tgaccgcggc gcacgctatg ctaagtatct ctacctggac     1080

ctttctaccc ttagcccgta cgtgtctgga cctaactccg ttaaagtggc gacccctctg     1140

gacgaattgg aaaagcataa acttaagatc gataaggcat atcttgtgtc atgcaccaac     1200

tctcgcgcat cagatatcgc cgctgcggct aaagttttca aagatgcagt ggcacgcact     1260

ggcggccctg tgcgagtggc cgacggcgtt gaattttacg tcgccgccgc atctaaagct     1320

gagcaaaaga tcgcggaaga agcaggtgac tggcaagctc ttatggacgc gggcgcaatc     1380

cccttgcctg ccggctgtgc agtttgtatc ggcctcggtg ccggcctgct caaggaggga     1440

gaagtcggca tcagcgcaag caatcgaaac tttaaaggcc gcatgggttc tcctgacgca     1500

aaggcctatc tcgcttcccc agaagttgtt gcggccagcg cactcaacgg agtaatctcc     1560

ggtccaggaa tctacaagcg accagaggac tggactggcg tatccattgg agaaggtgaa     1620

gtcgtggaat ccggctcacg cattgacacc acccttgaag caatggagaa gttcattggc     1680

caactggatt caatgattga ttcctcctct aaggctgtca tgccggagga atccactgga     1740

tccggtgcta ccgaggtcga catcgttcca ggtttccctg agaagatcga aggtgagatc     1800

cttttcctgg acgcggataa catcagcacc gatggaattt atccaggaaa atatacttac     1860

caggacgacg tgactaaaga taagatggcc caagtgtgca tggaaaacta tgatccggca     1920

ttctccggca tcgcccgcgc tggagatatc tttgtctcag gctttaattt cggctgcgga     1980

tcctcgcgtg agcaggccgc cacctccatt cttgccaagc agctcccgct ggtggtcgct     2040

ggatccatcg gaaacacgtt ctctcgcaac gctgttaaca acgcccttcc cttgctcgaa     2100

atgccacgct tgatcgagcg ccttcgtgaa gctttcggtt ctgagaagca gcctactcgc     2160

cgtacaggtt ggacatttac ctggaacgtg cgcacttccc aggttaccgt ccaggagggc     2220

cccggcggcg aaacctggag ccagtccgtt ccagcatttc cacccaattt gcaggacatc     2280

atcgctcagg gcggactgga gaagtgggtg aaaaaggaaa tttccaaggc g              2331


<210>  86
<211>  1254
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  86
atgtctgtct cagaggccaa tggaactgaa accatcaaac caccgatgaa cggtaaccca       60

tacggaccaa acccaagtga tttccttagc agagtcaaca acttttctat tattgagtct      120

acattaagag aaggtgaaca atttgcaaac gccttcttcg atacagaaaa gaagatccaa      180

atcgcgaagg ctttggataa ttttggcgtg gattacattg aattgactag tcctgtcgca      240

tctgagcaga gcaggcaaga ttgcgaagcc atatgtaagt taggtttaaa gtgcaaaatt      300

ttaacacata tacgttgtca catggacgat gctagagtag cagttgagac tggcgttgat      360

ggagtaaatg tggttatcgg tacatctcaa tatctaagaa agtactctca tggcaaggac      420

atgacgtaca taattgattc agctactgaa gtaataaatt tcgttaagtc caaaggcatt      480

gaagttcgtt tcagctctga agatagcttc agatccgatt tggttgatct gctatccctg      540

tacaaggcag ttgataagat tggggtgaat agagttggga tcgctgatac agtaggctgc      600

gctactccaa gacaggttta cgacttaatc cgtacattga gaggtgtggt tagttgcgac      660

attgaatgtc attttcataa tgatactggt atggctatcg caaatgcata ttgcgcattg      720

gaagccggtg ccactcacat tgatacttca attttaggta ttggagagag aaacggaatc      780

actcccctgg gtgctttatt ggcaagaatg tatgttacag atagagaata catcacccac      840

aagtacaagt tgaatcaact tagggagtta gaaaacttag ttgctgacgc tgtagaagtt      900

cagatcccat ttaataatta tatcacaggt atgtgtgctt tcacgcataa agcgggaatt      960

catgctaaag ccattttggc taacccttca acgtacgaaa ttttaaagcc cgaagatttt     1020

ggcatgtcca ggtacgtcca cgttggttct agattgacag gctggaatgc cataaagtca     1080

cgtgctgaac agttaaattt gcacttaact gatgcacaag cgaaagaatt aacggttaga     1140

atcaagaaac ttgccgatgt aaggacattg gccatggatg atgttgatag agtcttaaga     1200

gaatatcacg ccgatttgtc cgacgctgac agaatcacga aggaggcctc agca           1254


<210>  87
<211>  2040
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  87
atgtttgcaa caacctcatt acggcggtac acggaggcgt caagttctac gacacagacg       60

agtccatctt catcgtcttg gccagctccg gatgctgcac cacgggttcc gcaaactctt      120

acggagaaga ttgttcaagc gtattcatta ggactcgccg aaggacagta tgttaaagct      180

ggagattatg ttatgcttag tcctcaccgg tgtatgaccc atgacaattc ttggcctacg      240

gctttaaagt ttatggctat tggcgcatct aaggtgcata atcctgatca gattgtcatg      300

acattggacc atgatgtaca gaacaagagc gagaagaacc tcaagaaata tgaatccatt      360

gaaaaatttg ctaagcaaca tgggatcgac ttttatcctg cgggccatgg cgtcggacat      420

cagatcatga tagaagaggg atatgccttt ccgggcacgg tcactgtcgc ctcagattca      480

cattcgaata tgtatggtgg tgtaggatgt ttgggaaccc ctatggtcag aactgacgcg      540

gcgacaattt gggctacagg acgtacttgg tggaaagtcc cgcctatcgc aaaagtccaa      600

tttactggta ctttgccgga aggcgttacg ggcaaggatg taattgtcgc tctgagcggc      660

cttttcaaca aagatgaagt gttgaactat gccatagaat ttacagggtc tgaagaaacg      720

atgaagagtc tctcagtaga tactcgtctt acaattgcca atatgacaac ggagtggggt      780

gctctgacgg gcctgttccc tatcgacagc accctggaac aatggcttcg gcataaagcg      840

gccacggcgt cccgcacaga aaccgcgaga cgcttcgcag aagaacggat caatgaactg      900

tttgctaacc cgacggtagc agatcgcggc gcgagatatg cgaaatattt atacctggat      960

ctttccacgc tttctccgta tgtttcagga ccgaattctg tgaaggtagc tacaccgtta     1020

gatgagcttg aaaagcataa gttaaaaatc gataaagcgt accttgtttc gtgcacaaat     1080

agcagagcga gcgatatcgc tgcggctgcg aaggtattta aggacgctgt tgccagaaca     1140

ggcggaccag ttagagttgc cgatggcgta gagttttatg tggcggcagc gagcaaagca     1200

gaacagaaga ttgccgaaga agctggagat tggcaagcgt taatggatgc gggagccatc     1260

cctttaccgg caggttgcgc agtatgtatt gggcttgggg ctggactgct taaagaagga     1320

gaagtcggaa tcagcgcttc taaccgcaac ttcaaaggac gcatggggtc acctgatgcg     1380

aaagcttatc ttgcatcacc ggaggtggtt gccgcaagtg ctttaaacgg agtaattagt     1440

ggcccgggaa tttacaaacg gccggaagac tggacgggag tttcgatcgg ggaaggtgaa     1500

gtagtagaaa gcgggtctcg cattgatacc actctggaag cgatggaaaa gtttatcggg     1560

cagcttgact cgatgattga tagctcatct aaagccgtga tgcctgagga atcaactggg     1620

tcaggagcca cggaagtgga tatcgtcccg ggattcccgg aaaaaataga aggcgaaatc     1680

ttgtttcttg atgctgataa catttctaca gatggtatct atccgggaaa atatacgtac     1740

caggacgatg tcacgaaaga taaaatggcg caggtttgca tggagaatta tgacccggcc     1800

tttagcggaa tagcgcgagc gggcgatatc tttgtctctg gttttaactt tggttgtggc     1860

tcctcacggg aacaggcagc aacgtctatt ttggcaaaac aactcccgct tgttgtcgcg     1920

ggctctattg gaaacacatt ttctcggaac gcggtgaata acgctctgcc tctgctggaa     1980

atgccgagat taatcgagcg tttgcgcgaa gccttcggct cggaaaagca gccaacccgc     2040


<210>  88
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  88

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu Arg Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val Arg Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  89
<211>  1002
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  89
atggcatatc gcatttgcct tatagaagga gatggtattg ggcacgaagt cattccagcg       60

gctagacgtg tcctcgaggc caccggtctg ccgcttgagt ttgtagaagc ggaagccgga      120

tgggagacct tcgaacgccg tggcacaagc gtccctgagg aaacggtgga aaagatcctt      180

agctgccacg ccacgctgtt tggggctgcc acttcaccga cccgtaaggt gccgggtttt      240

ttcggagcca ttcggtattt gcggcgaaga ctggatctct acgctaatgt aagaccggct      300

aaatcgcgcc ctgtgccggg tagccgccca ggcgtggatc tggtaattgt cagagagaac      360

actgaaggct tgtacgttga gcaagagcgc cgttacctgg atgtggcgat tgcggatgcg      420

gtaatttcta agaaagctag cgaaagaatt ggaagagcgg ccttgagaat cgctgaagga      480

cggcctagaa aaacactgca cattgcacat aaagcaaatg tgttgccgct gacacaggga      540

ctgttcttgg ataccgttaa agaagttgca aaagactttc cgctggtaaa tgtgcaggac      600

attatagtgg ataattgtgc catgcagctg gttatgcgcc cagaacgttt tgatgtcatc      660

gttacaacaa accttcttgg cgatatcttg tcggatctgg cagccggatt agtaggggga      720

ttggggctgg ccccttccgg caacattggg gataccacag cagtctttga accggttcat      780

ggttcagccc cagatattgc tggcaagggg atcgcgaacc cgacagccgc aattctgtct      840

gcagcgatga tgcttgatta tttgggagaa aaggaagcag caaagcgcgt cgaaaaagcg      900

gttgatttag tcttagaacg tgggccacgt actccggacc tggggggaga cgcgaccacc      960

gaggccttta cggaagccgt cgttgaagct ctgaaatccc tg                        1002


<210>  90
<211>  418
<212>  PRT
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  90

Met Ser Val Ser Glu Ala Asn Gly Thr Glu Thr Ile Lys Pro Pro Met 
1               5                   10                  15      


Asn Gly Asn Pro Tyr Gly Pro Asn Pro Ser Asp Phe Leu Ser Arg Val 
            20                  25                  30          


Asn Asn Phe Ser Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe 
        35                  40                  45              


Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Gln Ile Ala Lys Ala 
    50                  55                  60                  


Leu Asp Asn Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro Val Ala 
65                  70                  75                  80  


Ser Glu Gln Ser Arg Gln Asp Cys Glu Ala Ile Cys Lys Leu Gly Leu 
                85                  90                  95      


Lys Cys Lys Ile Leu Thr His Ile Arg Cys His Met Asp Asp Ala Arg 
            100                 105                 110         


Val Ala Val Glu Thr Gly Val Asp Gly Val Asn Val Val Ile Gly Thr 
        115                 120                 125             


Ser Gln Tyr Leu Arg Lys Tyr Ser His Gly Lys Asp Met Thr Tyr Ile 
    130                 135                 140                 


Ile Asp Ser Ala Thr Glu Val Ile Asn Phe Val Lys Ser Lys Gly Ile 
145                 150                 155                 160 


Glu Val Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp 
                165                 170                 175     


Leu Leu Ser Leu Tyr Lys Ala Val Asp Lys Ile Gly Val Asn Arg Val 
            180                 185                 190         


Gly Ile Ala Asp Thr Val Gly Cys Ala Thr Pro Arg Gln Val Tyr Asp 
        195                 200                 205             


Leu Ile Arg Thr Leu Arg Gly Val Val Ser Cys Asp Ile Glu Cys His 
    210                 215                 220                 


Phe His Asn Asp Thr Gly Met Ala Ile Ala Asn Ala Tyr Cys Ala Leu 
225                 230                 235                 240 


Glu Ala Gly Ala Thr His Ile Asp Thr Ser Ile Leu Gly Ile Gly Glu 
                245                 250                 255     


Arg Asn Gly Ile Thr Pro Leu Gly Ala Leu Leu Ala Arg Met Tyr Val 
            260                 265                 270         


Thr Asp Arg Glu Tyr Ile Thr His Lys Tyr Lys Leu Asn Gln Leu Arg 
        275                 280                 285             


Glu Leu Glu Asn Leu Val Ala Asp Ala Val Glu Val Gln Ile Pro Phe 
    290                 295                 300                 


Asn Asn Tyr Ile Thr Gly Met Cys Ala Phe Thr His Lys Ala Gly Ile 
305                 310                 315                 320 


His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu Ile Leu Lys 
                325                 330                 335     


Pro Glu Asp Phe Gly Met Ser Arg Tyr Val His Val Gly Ser Arg Leu 
            340                 345                 350         


Thr Gly Trp Asn Ala Ile Lys Ser Arg Ala Glu Gln Leu Asn Leu His 
        355                 360                 365             


Leu Thr Asp Ala Gln Ala Lys Glu Leu Thr Val Arg Ile Lys Lys Leu 
    370                 375                 380                 


Ala Asp Val Arg Thr Leu Ala Met Asp Asp Val Asp Arg Val Leu Arg 
385                 390                 395                 400 


Glu Tyr His Ala Asp Leu Ser Asp Ala Asp Arg Ile Thr Lys Glu Ala 
                405                 410                 415     


Ser Ala 
        


<210>  91
<211>  1254
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  91
atgtctgtat cagaggcaaa cggcaccgag actattaaac caccaatgaa cggaaatcca       60

tatgggccga acccttcaga ctttctttca cgcgtcaaca atttttccat catcgaatcg      120

acgctgcgcg aaggtgaaca atttgcaaat gctttcttcg atacagaaaa gaaaatccaa      180

attgcgaagg cgcttgacaa ttttggagtc gattatattg agttaaccag ccctgtcgcg      240

tctgagcaat cacggcaaga ttgcgaagca atttgtaagt tagggctcaa atgtaaaatc      300

cttactcaca tacggtgcca tatggatgat gcccgggttg cagttgaaac tggcgtagat      360

ggtgtcaacg ttgtgattgg cacatctcaa tacctccgga aatacagtca cggaaaggac      420

atgacatata tcattgacag tgcaactgaa gtaattaact tcgtgaaatc aaaaggtatt      480

gaagtgcgct ttagttcaga agattcgttc agatcagacc tggttgacct cctttcattg      540

tataaagccg ttgataaaat tggcgtaaac cgcgtaggaa tcgctgatac ggtggggtgt      600

gctacaccgc ggcaggttta cgaccttatt agaacgctca gaggggttgt ttcatgcgat      660

attgaatgcc attttcataa cgacacgggg atggcgatcg cgaatgctta ctgcgcactt      720

gaagccggcg ccacacacat cgacactagt attttaggca ttggcgaacg taacggcatc      780

acaccacttg gcgcgctttt ggcacgtatg tatgtgactg accgagaata tattacccat      840

aaatataaac tgaatcagct gcgcgaactg gagaatcttg tcgccgacgc cgtggaagtg      900

cagatcccat tcaataacta tataactgga atgtgcgctt tcacccacaa agccggcatt      960

cacgctaaag caattcttgc taaccctagt acatatgaaa tcctgaaacc ggaagatttc     1020

ggaatgtctc gatatgttca tgtgggatct agacttacgg gctggaatgc tattaaatcc     1080

cgggccgagc agctgaatct ccatcttacg gatgcacagg caaaggagtt aacggttcgt     1140

attaaaaaat tagctgacgt aagaacgttg gcaatggatg atgtcgatcg ggttctccgc     1200

gaatatcatg ctgatttaag cgacgcggac cgcattacaa aagaagcatc cgcc           1254


<210>  92
<211>  1128
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  92
atgagagagt ggaagatcat cgattccact ctgagagaag gagagcaatt tgaaaaagct       60

aatttttcca cccaagataa ggtggaaatt gcaaaagcac ttgatgaatt tggaatcgag      120

tacatcgaag ttactacacc tgttgcttca cctcaatcca gaaaagatgc agaagtcctt      180

gcgagcttag gcttgaaagc gaaggtagta actcatatac aatgtagatt agatgccgcc      240

aaagtagctg tcgaaactgg agttcaaggg atagatctac tatttggtac ctccaaatac      300

cttagagctg cacatggtag agatattccc agaataatag aagaagcaaa ggaagtcata      360

gcatatatca gggaagcggc tcctcacgtt gaagtccgtt tcagtgccga agacacattt      420

agatctgaag agcaagattt attggcagtt tatgaggccg ttgctcccta cgttgacaga      480

gtcggcttag ctgatactgt tggtgttgct acaccaagac aagtttatgc gcttgtgcgt      540

gaagtcagaa gggttgtcgg acctcgtgtc gatatagaat tccatggtca taacgatact      600

ggctgcgcca tcgctaacgc ttatgaagcc atcgaagctg gggccaccca cgttgatact      660

accatattag gtataggtga aagaaacggt ataacacctc tgggaggttt tttagccagg      720

atgtatacgt tgcaaccgga atatgtcaga agaaaatata aattggaaat gttgcctgaa      780

ttggacagaa tggtggccag aatggtggga gtcgaaatcc ctttcaacaa ctatataacg      840

ggagaaactg ccttctcaca taaagcaggc atgcacttaa aggctattta tattaatcca      900

gaggcatacg agccataccc tccagaggtt tttggagtta agagaaaatt aattatcgcc      960

tcaaggctaa caggaagaca tgcaattaaa gcaagagctg aagaactggg attgcactat     1020

ggggaagaag aattacacag ggttacgcaa catattaagg ctcttgcaga tcgtgggcaa     1080

ttaacgctgg aagaattgga caggatttta agagaatgga ttaccgca                  1128


<210>  93
<211>  2040
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  93
atgttcgcca ctacttccct gcgacgttac acggaagcct cttcttccac cacccagact       60

tccccctcgt cttcttcctg gcctgctccc gacgccgccc cccgagtccc tcagactctg      120

actgagaaga tcgtccaagc ttattctctc ggactcgcag agggtcagta cgtcaaggcc      180

ggagactacg ttatgctctc cccccaccgg tgcatgacgc acgacaattc ctggcctacc      240

gctctgaagt ttatggccat cggagcctct aaggtccata accccgacca gattgtgatg      300

acactggatc acgatgttca gaacaagtcg gagaagaacc tgaagaaata cgagtccatc      360

gagaagttcg ccaagcaaca tggaattgac ttctaccccg caggtcacgg cgtcggacac      420

caaattatga ttgaggaggg ttacgctttc cccggaaccg tcacagtggc ctccgattcg      480

cactcgaata tgtatggcgg agtgggctgt ctcggcaccc ctatggtccg aacagatgct      540

gctacaattt gggccaccgg cagaacgtgg tggaaggtgc cacccattgc aaaggttcag      600

ttcactggaa cccttcctga gggcgtgacc ggaaaggatg tcatcgttgc tctcagcggt      660

ctgttcaaca aggacgaggt ccttaactat gcaattgagt tcaccggatc cgaggaaact      720

atgaagtctc tttccgttga tacgcgactc actatcgcca acatgactac cgaatgggga      780

gccctgactg gtctcttccc aatcgattcc acgctcgagc agtggctgcg acacaaggcc      840

gctaccgcct cccggaccga gacagccaga cggtttgcag aagagcgaat taacgagctg      900

tttgctaacc ccacggttgc tgaccgaggc gccagatacg ctaagtatct gtatctggac      960

ctgtctactc tctctcctta tgtctctggt cccaactccg tgaaggttgc aacacccctg     1020

gatgaactgg agaagcacaa gctgaagatc gataaggcct acctcgtgtc ttgcacaaac     1080

tcgcgagctt cggatatcgc cgctgccgcc aaggtgttta aggacgccgt tgcccgtacc     1140

ggcggccctg tccgagtcgc cgacggtgtc gaattctacg tggcagccgc ctccaaggcc     1200

gaacagaaga ttgccgagga agctggcgac tggcaagccc tcatggatgc tggagctatc     1260

cctctgcctg caggttgcgc tgtctgcatc ggcctcggag ccggactcct gaaggaaggt     1320

gaagtcggaa tctcggccag caaccgaaac ttcaagggcc gtatgggctc gccagacgcc     1380

aaggcctatc tggcctcccc cgaggtggtc gccgcttctg ccctcaacgg tgtcatctct     1440

ggaccaggaa tctacaagcg acccgaggat tggactggcg tctctattgg agagggtgag     1500

gttgtcgaga gcggttcgcg aatcgacact accctcgaag ccatggagaa gtttatcggc     1560

cagctggatt ccatgatcga ctcgtcctcc aaggctgtca tgcccgagga gtcgactggt     1620

tccggagcta cagaagttga cattgtcccc ggcttcccag agaagattga aggcgagatc     1680

ctcttcctcg acgctgacaa catttccact gacggcatct acccaggcaa gtacacctac     1740

caggatgacg tgaccaagga caaaatggct caggtgtgca tggagaacta cgaccccgct     1800

ttctcgggta ttgcccgagc cggtgacatt ttcgtgtctg gatttaactt tggttgtggc     1860

tcctctagag agcaggccgc taccagcatc ctcgccaagc agctgcccct tgtggttgct     1920

ggttccatcg gcaacacctt ctcgcgaaat gctgtgaaca acgccctccc ccttctcgaa     1980

atgcctcggc tcattgagcg actgagagaa gctttcggct ctgagaagca acccactcgt     2040


<210>  94
<211>  2331
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  94
atgttcaagc gaactggctc cctgctcctg cggtgtcgag catcccgggt ccctgtgatt       60

ggacgacccc ttatttcgct ctctacttcg tcgacatctc tgagcctgtc gcgacctcga      120

tcgttcgcaa ccacatctct ccgacggtac accgaggctt cgtcttctac cacccagacc      180

tctccctcct cctcgtcttg gcccgcaccc gatgccgccc cccgagtccc ccagaccctg      240

accgagaaaa ttgttcaggc ctactccctt ggcctcgccg agggtcagta tgtgaaggcc      300

ggcgactacg tcatgctgtc tccccatcga tgtatgacac acgacaactc ttggcctacc      360

gccctgaagt tcatggccat cggcgcctct aaggttcaca accccgatca aattgtcatg      420

accctcgatc acgacgttca gaacaagtcc gaaaagaacc tgaagaagta cgaatcgatc      480

gagaaattcg ccaagcagca tggtatcgac ttctaccctg ctggccatgg agttggtcac      540

caaatcatga ttgaagaggg ctacgccttt ccaggtactg tcaccgtggc ctcggactcc      600

cactccaaca tgtacggcgg tgttggctgc ctgggaaccc ccatggtgcg aactgatgct      660

gctactattt gggctaccgg cagaacgtgg tggaaggttc cccccatcgc caaggttcag      720

ttcaccggca ctctccctga gggtgttacc ggaaaggatg tcattgtcgc cctttcggga      780

ctcttcaaca aggacgaggt tcttaactac gctattgagt ttactggtag cgaagagacc      840

atgaagagcc tcagcgtgga taccagactg accattgcta atatgacgac cgagtggggc      900

gctcttaccg gcctcttccc cattgactcg accctcgagc aatggctgag acataaggcc      960

gctaccgctt ccagaactga aacagcccga cgtttcgccg aggagcggat taatgagctt     1020

tttgccaacc ctacagttgc cgaccgaggt gctcggtacg ctaaatacct ttacctcgac     1080

ctctccacgc tttcccctta cgtctccggc cccaacagcg tcaaggttgc cactcccctc     1140

gacgagctcg agaagcataa actgaaaatc gacaaggctt acctcgtcag ctgtactaac     1200

tctcgagctt cggacatcgc cgccgctgcc aaggtcttta aggacgctgt cgcccggacc     1260

ggcggccccg tgcgtgtcgc cgacggtgtt gaattctacg tcgccgctgc ctctaaggct     1320

gagcagaaga tcgccgagga ggctggtgat tggcaagcac tgatggatgc aggcgctatt     1380

cccctgcctg ccggatgcgc cgtttgtatc ggacttggtg ctggcctgct caaggagggt     1440

gaagttggca tttcggcctc taatcgaaac tttaagggtc ggatgggttc ccccgacgct     1500

aaggcttacc tggcttctcc cgaggtggtg gccgcatctg ctctgaacgg agttatctcc     1560

ggacctggta tctacaagcg acccgaggac tggaccggag tttccatcgg tgaaggtgag     1620

gtcgtcgagt ccggcagccg tatcgacacc accctggagg ctatggaaaa gttcattgga     1680

cagctcgatt ctatgatcga ttcgtcgtcg aaggctgtga tgccagagga gtccaccgga     1740

agcggtgcta ccgaggtcga tatcgtccct ggcttccctg agaagatcga aggtgagatt     1800

ctctttctgg acgccgacaa catttctact gatggaattt accctggcaa gtacacctac     1860

caagacgacg ttaccaagga caagatggct caggtgtgca tggagaacta cgacccagct     1920

ttctctggaa tcgcccgtgc cggcgacatc tttgtctccg gcttcaactt tggttgcggt     1980

tccagccgag agcaggccgc tacttccatt ctggcaaagc aactgccact cgtggttgct     2040

ggctctattg gaaacacctt ttctcgtaat gccgtgaaca acgctctccc tctgcttgag     2100

atgcctcgac tgattgaacg tctccgagag gcctttggat ccgagaagca acctacccgg     2160

cgaaccggat ggaccttcac atggaacgtg agaacctccc aggttaccgt ccaggagggt     2220

cccggaggtg agacctggtc tcagagcgtg cccgccttcc ccccaaacct ccaggatatt     2280

atcgcccaag gtggactcga gaagtgggtg aaaaaagaga tctccaaggc t              2331


<210>  95
<211>  2040
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  95
atgttcgcaa ccacgtcatt gcgacgttac acagaggcta gctcaagcac cacccagaca       60

tcgccatcct catcctcctg gcctgcccca gacgccgcac cacgtgtgcc ccagactctg      120

actgagaaaa tcgtgcaagc atactctctc ggccttgccg agggtcaata cgttaaggcc      180

ggtgactatg tcatgctgtc cccacatcgc tgtatgaccc atgacaactc ctggccaaca      240

gccctgaagt tcatggctat cggtgcatct aaggtacaca acccagacca aatcgttatg      300

acactcgacc atgacgtgca gaacaagagc gaaaaaaacc tcaaaaagta cgaatccatc      360

gagaagtttg cgaagcagca tggcattgac ttctacccgg ctggccacgg cgtaggccat      420

caaatcatga tcgaagaagg ttacgccttt cctggaaccg tcaccgttgc atcagattcc      480

cattccaata tgtatggtgg tgtgggctgc ctcggcaccc ctatggtgcg cactgacgca      540

gccacaatct gggccacggg ccgcacctgg tggaaggtgc ctcctatcgc caaggtgcag      600

tttactggta ctctgcctga gggcgttacc ggtaaagatg tgatcgttgc gttgtcgggc      660

ctgtttaaca aagacgaagt gctcaactac gcgatcgagt ttaccggcag cgaggaaacc      720

atgaaaagcc tgtctgttga cacccgtctg accatcgcga acatgaccac ggaatggggt      780

gctctgaccg gtctgttccc cattgattcc accctcgagc aatggctccg ccacaaggcg      840

gcgactgcgt ctcgaactga gacagcacgc cgcttcgctg aggagcgcat caacgaactc      900

ttcgccaatc caacagttgc agaccgtggc gcacgttacg ccaaatactt gtatctggat      960

ttgtccaccc tgtcccctta tgtcagcggt ccgaacagcg taaaggtcgc aacacctctc     1020

gatgaactgg agaaacacaa attgaaaatc gacaaggcat acctcgtctc ctgcaccaac     1080

agccgtgcga gcgacattgc agcggccgct aaggtattca aggatgccgt cgcccgtact     1140

ggtggtcctg tgcgcgtggc agacggagtc gaattctacg tggccgcagc ctcaaaggct     1200

gaacagaaga tcgctgaaga ggcgggagac tggcaagccc tgatggacgc aggtgcaatc     1260

ccccttcccg caggttgcgc cgtgtgtatt ggcctcggag ctggtctcct gaaagaggga     1320

gaagtgggta tttccgcctc aaaccgcaat ttcaagggcc gcatgggttc gccagatgca     1380

aaagcctact tggcctctcc tgaagtggtc gctgcctctg cgcttaacgg tgtgatctcc     1440

ggcccgggca tttataagcg cccagaggac tggaccggcg tctcgatcgg cgaaggcgag     1500

gttgtggaat cgggcagccg tattgacacc acacttgagg caatggagaa gtttattggc     1560

caacttgatt ctatgatcga ttcaagctct aaggctgtca tgccagaaga aagcacagga     1620

tcaggtgcaa ctgaagtcga cattgttcca ggattccctg aaaagattga aggagagatt     1680

ctgtttcttg acgccgataa cattagcacc gacggcattt atcctggcaa gtatacctat     1740

caagatgatg ttacgaagga caagatggcc caagtttgca tggagaacta tgatcctgca     1800

ttctcaggta tcgcccgcgc tggcgacatt ttcgtaagcg gcttcaactt cggttgcggc     1860

tcttctcgtg aacaagctgc aacctccatt cttgctaaac agcttccatt ggtggtcgcg     1920

ggctctattg gcaacacctt ctcccgcaat gctgtgaaca acgcactccc gctccttgaa     1980

atgccacgtc tgatcgagcg cttgcgagag gcattcggct ctgagaagca accaacacgt     2040


<210>  96
<211>  387
<212>  PRT
<213>  Unknown

<220>
<223>  Clostridium sp. C8

<400>  96

Met Ser Ile Lys Asn Leu Asn Asn Gly Lys Glu Val Phe Ile Val Asp 
1               5                   10                  15      


Thr Thr Leu Arg Asp Gly Glu Gln Thr Ala Gly Val Val Phe Ala Asn 
            20                  25                  30          


Glu Glu Lys Ile Ala Ile Ala Ser Met Leu Ser Glu Leu Gly Val Asp 
        35                  40                  45              


Gln Leu Glu Val Gly Ile Pro Thr Met Gly Gly Asp Glu Lys Glu Ala 
    50                  55                  60                  


Ile Lys Gln Ile Val Lys Arg Asn Gln Lys Ser Ser Ile Met Ala Trp 
65                  70                  75                  80  


Asn Arg Ala Val Ile Lys Asp Ile Glu Glu Ser Ile Asp Cys Gly Val 
                85                  90                  95      


Asp Ala Val Ala Ile Ser Ile Ser Val Ser Asp Ile His Ile Gln His 
            100                 105                 110         


Lys Leu Lys Thr Ser Arg Gly Trp Val Leu Glu Asn Met Val Lys Ser 
        115                 120                 125             


Val Glu Phe Ala Lys Lys Asn Gly Leu Tyr Val Ser Val Asn Gly Glu 
    130                 135                 140                 


Asp Ala Ser Arg Ala Asp Arg Glu Phe Leu Ile Gln Phe Ile Glu Val 
145                 150                 155                 160 


Ala Lys Gln Ala Gly Ala Asp Arg Phe Arg Tyr Cys Asp Thr Val Gly 
                165                 170                 175     


Ile Met Glu Pro Phe Lys Ile Asn Glu Asp Ile Arg Tyr Leu His Ala 
            180                 185                 190         


Lys Thr Asn Phe Asp Ile Glu Met His Thr His Asn Asp Phe Gly Met 
        195                 200                 205             


Ala Thr Ala Asn Ala Ile Ala Gly Ile Met Gly Gly Ala Ser His Val 
    210                 215                 220                 


Gly Val Thr Val Asn Gly Leu Gly Glu Arg Ala Gly Asn Ala Ala Leu 
225                 230                 235                 240 


Glu Glu Val Leu Met Ala Leu Met Phe Val Tyr Asn Tyr Gly Gly Asn 
                245                 250                 255     


Ile Ser Thr Thr Met Phe Arg Glu Val Ser Glu Tyr Val Ser Arg Ala 
            260                 265                 270         


Ser Gly Arg Ile Leu Pro Ala Trp Lys Ala Ile Val Gly Asp Asn Met 
        275                 280                 285             


Phe Ala His Glu Ser Gly Ile His Ala Asp Gly Ala Ile Lys Asn Pro 
    290                 295                 300                 


Lys Asn Tyr Glu Ala Phe Asp Pro Gly Ile Val Gly Leu Glu Arg Gln 
305                 310                 315                 320 


Ile Val Ile Gly Lys His Ser Gly Lys Ala Gly Ile Ile Asn Lys Phe 
                325                 330                 335     


Lys Glu Tyr Gly Ile Asp Leu Asp Asn Asn Ser Ala Lys Asp Ile Leu 
            340                 345                 350         


Glu Met Val Arg Ser Thr Ser Val Arg Leu Lys Arg Ser Leu Phe Asp 
        355                 360                 365             


Lys Glu Leu Val Gln Ile Tyr Lys Glu Tyr Leu Arg Leu Arg Glu Glu 
    370                 375                 380                 


Lys Val Asn 
385         


<210>  97
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  97
atgagcatca aaaatttgaa taacggaaag gaggtgttta tagtagatac cactttaaga       60

gatggtgaac agacagcggg tgtggtgttc gcgaatgagg aaaaaatcgc gatcgcgagt      120

atgctttccg agctcggagt ggatcaactg gaggtgggca ttccgacaat gggcggagat      180

gagaaggagg ccatcaaaca aatcgtaaaa cgtaatcaga aatcaagcat tatggcctgg      240

aaccgcgctg ttattaagga tatcgaagaa tctatcgact gcggagtgga cgcagtcgcg      300

atctcaattt cagtaagtga tattcacatt cagcataagc tcaaaacaag ccgggggtgg      360

gttctggaaa atatggtcaa gtcagttgaa tttgccaaaa agaatggcct gtatgtgtct      420

gtcaatggcg aggacgcctc tcgtgcggat agagaatttt taatccagtt cattgaggtg      480

gcgaaacagg caggtgctga tagatttaga tactgtgaca cagtcgggat tatggagcct      540

ttcaagataa acgaagatat tcggtatttg catgctaaaa ccaatttcga catcgaaatg      600

cacacgcaca acgattttgg aatggctact gctaacgcta tagctggaat catgggcggt      660

gcgagccatg tcggcgttac ggtgaacggg ctgggagagc gtgctggtaa tgctgcttta      720

gaggaggtcc tgatggcttt gatgtttgtc tataattacg gcggaaacat ttcgacaacc      780

atgtttagag aagtttcaga atatgtgagc cgagctagcg gacgtatttt gcctgcctgg      840

aaggcaattg tgggtgataa catgtttgca catgaatctg gaatccacgc cgatggggca      900

ataaagaatc cgaaaaatta tgaagccttt gatcctggta tcgtaggttt ggagcgccag      960

atcgtgatag gaaagcacag tggtaaagcg ggaattatta ataaatttaa agaatatggt     1020

atcgatctgg ataacaactc ggcgaaggac attttagaaa tggttcgcag cacgtcagtg     1080

cgtttaaagc ggtccctgtt cgacaaagaa ttagtacaaa tatacaaaga ataccttcgt     1140

ttgcgcgagg aaaaagtcaa t                                               1161


<210>  98
<211>  1002
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  98
atggcttacc ggatctgtct cattgagggc gacggcattg gccacgaggt gatccctgcc       60

gcccgtcgag tcctcgaggc aaccggtctt cccctcgagt ttgtcgaggc agaggctggc      120

tgggagacct ttgagagaag aggtactagc gtgcctgagg agaccgttga gaagattctt      180

tcctgtcacg ctaccctgtt tggcgcagct acttctccca cgagaaaagt tcctggattc      240

ttcggtgcca ttcgatacct gcgtagacgt ctggacctgt acgccaacgt tagacccgca      300

aagtctcgac ccgttcccgg ctctcgtcca ggcgttgacc tggtcattgt tcgagagaac      360

accgagggcc tgtacgtcga acaagaacga cgataccttg acgtcgctat cgctgacgcc      420

gtgatttcta aaaaggcttc tgagcgtatc ggtcgagcag ctctgcgaat cgccgagggt      480

cgaccccgaa agactctgca cattgcacat aaggcaaatg tgcttccact cacacagggc      540

ctcttcctgg acacagtcaa ggaagtcgcc aaggacttcc ccctcgtgaa cgttcaggac      600

attatcgtcg ataactgcgc catgcagctg gttatgcgac cagagcgatt tgacgtcatt      660

gttaccacga accttctggg cgacattctc tccgacctcg ccgccggact ggtgggcgga      720

ctcggtctgg cacccagcgg taacattggc gacaccaccg ccgtgtttga gcctgttcac      780

ggttctgccc ctgatattgc cggtaagggc atcgccaacc ccaccgccgc tatcctgtcc      840

gccgccatga tgctcgacta cctcggtgaa aaggaggctg ctaagcgtgt tgagaaggct      900

gtcgatcttg tcctggaacg tggaccccga acaccagacc tgggcggcga tgctacgaca      960

gaagccttca cggaagccgt ggtggaggcc ctcaagtcgc tc                        1002


<210>  99
<211>  2052
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  99
atgtttcatt cctcaagagc gtggctaaaa ggacaaaatc tgacagaaaa gatagtgcaa       60

tcttacgccg ttaacttacc agaaggcaaa gttgtacatt ctggcgatta cgtctctatt      120

aaacctgctc actgtatgtc tcatgataat tcctggccag tggctttaaa atttatgggg      180

cttggcgcga ccaaaattaa aaacccctca caaattgtta ctacgctgga tcacgacatt      240

cagaataaat ctgagaaaaa cttgaccaaa tacaagaaca tcgagaactt tgccaaaaag      300

caccatatag atcactatcc agctggtaga ggtataggac atcaaatcat gattgaagaa      360

ggctacgctt tcccactgaa catgacagtt gcttcagatt cacatagtaa tacttatggg      420

ggacttggtt cattgggaac ccccattgtt agaacagacg ctgctgctat ctgggcaact      480

ggtcaaacat ggtggcaaat tcctccagtg gcacaggtcg aacttaaggg ccaattacct      540

caaggtgtta gtggaaaaga cattattgtt gctttgtgcg gtttattcaa taacgatcaa      600

gtattaaatc atgcgattga attcactggg gactctctga atgctttgcc tatagatcat      660

aggttaacta ttgccaatat gacaactgaa tggggggctc ttagcggttt gttcccagtg      720

gataagaccc ttatagactg gtacaagaat cgtttgcaaa aattaggtac aaacaatcat      780

cctagaatta atcctaaaac cataagagcg ctagaagaga aggctaaaat accgaaagcg      840

gataaagacg cccattacgc caaaaaattg attattgact tagcaacctt gacccattat      900

gtgtcaggtc caaattctgt aaaggtgtca aatactgttc aagacctgtc tcaacaagac      960

atcaagatta acaaagccta tttggtgtct tgtacgaata gcagattaag tgacttgcaa     1020

tcagcagcag atgttgtatg ccctactgga gatttaaata aagttaacaa ggtcgctcca     1080

ggcgttgaat tttacgtggc ggctgcttca tccgaaattg aagccgatgc taggaagagt     1140

ggtgcttggg agaaactact aaaagctggt tgtatcccat taccgagtgg ttgtggtcct     1200

tgtataggtt taggagccgg actgttggaa ccgggagaag tgggtatctc tgcgactaac     1260

agaaacttca agggaaggat gggatctaaa gatgccttgg cctatctggc atctcctgct     1320

gtagttgcgg catcagccgt gttaggaaaa atatctagcc cagctgaggt tctttcaact     1380

tcagagatac ctttctccgg tgtcaagaca gaaattattg agaatcctgt cgtcgaagaa     1440

gaagtcaacg ctcaaacaga agcaccaaag caatctgttg agattcttga aggttttccg     1500

agagaattca gtggagaatt ggtgctatgc gatgcagaca acattaacac tgatggtatc     1560

tacccaggga aatacactta tcaagacgac gttcctaagg aaaagatggc tcaagtttgc     1620

atggaaaact atgacgcaga atttaggact aaagtacatc ccggtgacat tgttgtgagc     1680

ggttttaatt tcggtaccgg ttcatctaga gagcaagcag ccacagcttt gttggctaag     1740

ggcatcaatt tggtggtgtc tggtagcttt gggaacattt tctctcgtaa ttctattaac     1800

aatgctttgc ttacacttga gattccggcc ttaattaaaa agttaagaga gaaataccag     1860

ggcgcgccta aagaattgac aagacgtacg ggctggttcc tgaaatggga cgttgcggat     1920

gcaaaagtgg ttgttacaga aggttctttg gacggcccgg tgatcctgga gcaaaaggtt     1980

ggagaactag gaaaaaatct gcaagaaatt attgtcaagg gtggcttaga aggttgggtg     2040

aagagtcaac ta                                                         2052


<210>  100
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  100
atgtccatta agaacctgaa taatggcaag gaagtgttca ttgttgatac caccctccga       60

gacggcgagc agactgccgg cgtggttttc gccaacgagg aaaagattgc aattgcaagc      120

atgcttagcg agcttggcgt cgatcagctt gaagtgggca ttcctaccat gggaggcgac      180

gagaaggagg ccattaagca gatcgttaag cgtaatcaga agtcctcgat catggcctgg      240

aaccgagcag ttatcaaaga catcgaagaa tccatcgact gcggcgtgga cgccgttgcc      300

attagcatct cggtgtccga tattcacatt cagcacaaac ttaagacttc tcgaggctgg      360

gttttggaaa atatggtaaa gtccgtcgag ttcgctaaga agaatggttt gtatgttagc      420

gtaaacggcg aagatgcgtc gcgagcagac cgcgaatttc tgatccagtt tatcgaagtg      480

gcaaaacagg cgggcgccga tcgcttccgc tactgtgaca ccgttggaat catggaacca      540

tttaagatca atgaggatat ccgctacctc catgctaaga ccaacttcga tatcgagatg      600

cacacgcata acgattttgg tatggctact gctaacgcaa ttgcaggtat catgggcgga      660

gcctctcacg tgggtgtcac ggtcaacggt ctcggcgaac gcgctggcaa cgctgcgttg      720

gaggaagtct tgatggctct catgtttgtc tataactacg gtggcaacat ctccactacg      780

atgttccgag aagtctccga gtatgtgtcc cgcgcaagcg gccgtatcct gcccgcgtgg      840

aaggcgatcg ttggcgataa tatgtttgct catgagtccg gcatccacgc cgacggagcg      900

atcaagaatc ctaaaaacta cgaagccttt gatccaggca tcgtcggctt ggagcgccag      960

atcgttattg gtaaacacag cggcaaggcg ggcatcatca acaagtttaa ggaatacggc     1020

attgatttgg ataataactc tgccaaagat attcttgaaa tggtgcgctc tacctcggtc     1080

cgcctgaaac gtagcctttt tgataaggaa cttgttcaaa tctacaaaga ataccttcgt     1140

ctccgagaag agaaggtgaa c                                               1161


<210>  101
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  101
atgtccatca agaacctcaa caacggcaaa gaggtgttca ttgtggacac tacactgcga       60

gacggcgagc agaccgctgg cgtcgtgttc gcaaacgagg agaagatcgc cattgcttcg      120

atgctctcgg aactgggcgt cgatcaactg gaggtgggta tccctaccat gggcggagac      180

gaaaaggagg ccattaaaca aattgtcaag cggaaccaga agtctagcat catggcatgg      240

aaccgagctg ttatcaaaga catcgaggag agcattgatt gtggtgtcga tgccgtcgcc      300

atctcgatct ctgtttctga catccacatt cagcacaaac tgaagacctc tcgaggttgg      360

gtcctggaga acatggtcaa gtcggtggaa ttcgccaaga agaatggtct gtacgtgtcc      420

gtcaacggcg aggacgcctc ccgagctgac cgtgagttcc ttatccagtt tattgaagtt      480

gccaagcaag ctggagctga tcgattccga tattgtgaca ccgtgggaat tatggagccc      540

tttaagatta acgaggacat ccgatacctg catgcaaaga cgaatttcga catcgagatg      600

cacacccaca acgacttcgg tatggctact gctaacgcca ttgctggcat tatgggaggt      660

gcctcgcacg tcggtgttac cgtgaacggt cttggcgagc gagccggcaa cgctgccctg      720

gaggaggtcc tgatggccct catgtttgtt tacaactacg gcggcaacat ctccaccact      780

atgttccgag aagtttccga gtatgtttct cgagcatcgg gacgaattct cccagcctgg      840

aaggccatcg ttggtgataa tatgttcgcc cacgaatctg gaatccacgc cgacggagct      900

attaagaacc ccaagaacta cgaggctttt gaccccggca ttgtgggact ggagcgacaa      960

atcgttatcg gtaagcattc cggaaaggcc ggcatcatca acaagtttaa ggagtacggt     1020

attgacctcg acaacaactc cgccaaagac attcttgaaa tggtccgaag cacctccgtc     1080

cgactgaaga gatccctgtt cgataaagag cttgtccaga tttacaaaga gtacctccga     1140

ctcagagagg agaaggttaa c                                               1161


<210>  102
<211>  1002
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  102
atggcgtacc gtatttgttt gatcgagggc gatggcatcg gccacgaagt catcccagct       60

gcgcgccgcg tgctggaggc taccggactt cctctggaat tcgttgaagc agaagcgggc      120

tgggaaacct tcgagcgccg cggcacctcc gtgcccgaag aaactgtgga aaagatcctt      180

tcgtgtcatg caacgctgtt cggcgctgca acctcaccaa cccgcaaggt gcctggattc      240

ttcggcgcca tccgctacct gcgccgccgc ctcgatttgt acgctaacgt gcgccccgct      300

aaatcccgtc ctgtccctgg ctcgcgccct ggtgtagact tggtcatcgt ccgtgaaaac      360

actgaaggcc tgtacgtcga gcaagagcga cgctatctcg acgtggcaat cgcggatgcc      420

gttatctcca agaaggcatc agagcgtatt ggccgagccg cgctccgcat cgcggaaggc      480

cgaccgcgca agaccctcca catcgctcac aaagccaacg tcttgccgct cacgcagggt      540

ttgtttctgg acacggtgaa ggaggtggca aaggacttcc cattggttaa cgttcaagat      600

atcattgttg acaattgcgc aatgcagctg gtcatgcgac ccgagcgatt tgatgtgatt      660

gtcacgacga atttgctggg tgatatcctc tccgatttgg cggctggcct ggtgggcggt      720

ctcggcctgg caccaagcgg caacatcggt gatactaccg ccgtgttcga gccggtccac      780

ggctcagcgc ctgatattgc aggaaaaggt atcgccaacc cgacggcagc gatcctttcc      840

gcagcaatga tgctggatta ccttggcgaa aaggaagcgg cgaaacgcgt tgaaaaggcg      900

gtggacctcg tgctcgagcg cggaccacga accccggatt tgggtggcga cgcaaccacg      960

gaagctttta ccgaagctgt cgttgaagct ctgaagtctc tc                        1002


<210>  103
<211>  2331
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  103
atgttcaaga gaaccgggag tctcctgctg cgttgtcgcg cgtcgcgagt tccggtgatt       60

ggtcgtcctt tgatttctct gtcgaccagc tcaacgtctc ttagccttag cagacctcgc      120

agtttcgcca ccacgagctt gcgaagatac actgaagcgt catcaagcac cactcagaca      180

tcgccaagta gctcttcttg gcctgctccg gatgcagcac cacgtgtgcc acaaaccttg      240

acagagaaaa tcgttcaagc ctacagcctg ggacttgcag aggggcagta tgtgaaagcg      300

ggagactatg ttatgctttc tcctcatcgc tgcatgactc acgataactc gtggcctaca      360

gcgttaaaat ttatggcaat tggagcatcg aaagtgcata acccggacca aatagtgatg      420

accttggatc acgacgtcca aaacaaatct gaaaaaaatc tcaaaaagta tgaatcgatc      480

gaaaaattcg ccaaacaaca tggcatcgat ttctaccctg cgggccacgg agttgggcac      540

cagattatga tcgaagaagg atatgccttt ccgggtacag taaccgtagc ctctgacagc      600

cacagtaaca tgtatggggg cgtcggttgc ctgggaacgc ctatggttcg cacggacgca      660

gccacaattt gggcgacagg gcgaacgtgg tggaaagtac cacctatcgc gaaagtacag      720

ttcacgggca cgctgcctga aggagtgaca ggtaaagatg ttattgttgc gcttagtggt      780

ctctttaata aggatgaagt cttgaattat gcgatagagt ttacagggtc cgaggaaaca      840

atgaaaagcc tgagtgttga tacccgattg acgattgcta acatgactac tgaatggggt      900

gcacttacag gtttgtttcc tatagatagc actttagaac aatggctgcg acataaagcg      960

gcaacagcgt cacgcacgga aaccgcgaga cgattcgctg aagaacgtat caatgaactc     1020

tttgccaatc caacagttgc ggatcggggc gcccgctatg caaaatatct ttatctcgac     1080

ctctccaccc tgagcccata tgtttcagga ccgaatagcg tgaaggtcgc gactccgtta     1140

gatgaattag aaaaacataa attaaaaatt gacaaggctt accttgttag ctgtacaaac     1200

agccgtgcat cggatatagc tgccgcggcg aaagttttta aggatgcggt cgctcggacc     1260

ggcggtccgg taagagttgc tgacggggtg gaattctacg tcgcagccgc tagcaaagcg     1320

gaacaaaaaa tcgcggagga agcaggggat tggcaagcgt tgatggatgc gggtgccatc     1380

ccgctcccag caggctgcgc tgtttgtatt ggtttagggg ctggactctt aaaagaaggg     1440

gaggttggca ttagcgcaag caatcgcaat tttaagggcc gaatgggtag tccggatgcg     1500

aaagcgtatt tggcatcacc ggaggtggtc gccgctagtg ccctcaatgg ggtcatttcc     1560

gggccgggga tctacaaaag accagaagat tggacaggag tcagtatcgg cgaaggcgaa     1620

gtagtcgaat caggtagccg tattgataca acacttgaag cgatggaaaa gtttattgga     1680

caactcgata gcatgatcga tagctcaagc aaagctgtta tgccggaaga atcaacgggg     1740

tcaggagcaa cagaagtgga cattgtcccg ggctttccgg agaaaatcga aggggagatt     1800

ttatttttag atgccgataa tatttcaacg gatggcattt acccaggcaa atatacgtat     1860

caggatgacg tcacaaagga taaaatggcg caggtatgta tggaaaacta tgatcctgca     1920

ttttctggca tcgcgcgggc gggcgacatt ttcgtcagcg gctttaattt cggatgtgga     1980

tcatcgagag agcaagcggc gacatcgatt cttgctaaac agctgccgct tgtggtcgcg     2040

gggagtattg gaaacacatt tagccgtaat gctgtgaaca atgccttgcc actgttagaa     2100

atgccgagac tgatcgaacg tctgcgagaa gcttttggga gcgaaaagca accgacccgt     2160

agaaccggtt ggaccttcac gtggaatgtc agaacatccc aagtcacagt gcaagaagga     2220

ccgggcggcg agacatggtc gcaatctgtt ccagcatttc ctccgaacct ccaagatata     2280

attgcgcagg gtggtctcga aaagtgggtt aagaaagaaa taagtaaggc a              2331


<210>  104
<211>  1254
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  104
atgtccgtat ccgaggccaa tggcaccgag acgatcaagc cgccgatgaa cggcaacccg       60

tacggcccaa acccttccga tttcctgtcc cgtgtgaata acttttccat catcgaatca      120

actttgcgag aaggtgaaca gtttgccaac gcattcttcg ataccgagaa aaagattcaa      180

atcgcgaaag ctctcgacaa tttcggtgtg gattacattg agctcacttc cccagtggct      240

agcgagcaat ctcgacagga ttgcgaagcg atctgcaagt tgggtctcaa atgcaaaatc      300

ctgacccaca tccgctgtca catggacgat gcccgcgtgg cagtggaaac tggtgtggac      360

ggcgtaaacg ttgttatcgg cacttctcag tatctccgaa aatactccca cggaaaagat      420

atgacataca ttatcgattc cgcaaccgaa gtaatcaact ttgtgaaatc gaaaggcatt      480

gaggtgcgtt ttagctccga agattctttt cgctccgatc ttgtggatct gctttctttg      540

tacaaagcag tggataagat tggagtcaac cgagttggca tcgcagatac cgtcggctgc      600

gctacgcctc gtcaggtgta tgaccttatt cgcaccctgc gaggtgtcgt ctcctgtgat      660

atcgaatgcc atttccataa cgataccggc atggcgatcg ccaatgcata ctgcgccctg      720

gaagccggtg caacccacat cgatacctcg atcctcggca ttggtgagcg aaacggtatt      780

acaccactcg gagcgctgct cgcacgaatg tacgtgacag atcgcgaata cattacccat      840

aaatacaaac tgaaccaact tcgcgagttg gagaacttgg tcgcagacgc tgttgaggtg      900

cagatcccct ttaacaacta catcacaggc atgtgcgcat tcacccacaa agcaggcatc      960

cacgcaaagg cgattctcgc caatccttct acatatgaaa ttctgaagcc cgaggatttc     1020

ggcatgtccc gctatgtcca cgttggttcc cgcctgaccg gttggaacgc gatcaaatcc     1080

cgagcagaac agctcaactt gcacttgacc gacgcccagg caaaggaact taccgtccgt     1140

atcaaaaaac tggccgatgt acgcacattg gcaatggatg atgtcgaccg tgtgctgcgc     1200

gagtatcacg cggatttgtc cgatgcagat cgcatcacca aggaagcctc tgcc           1254


<210>  105
<211>  1254
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  105
atgtcggtgt ctgaggccaa cggtaccgag acgattaagc ctcccatgaa cggtaacccc       60

tacggtccca atccttctga cttcctctct cgagttaata acttctccat catcgagtcg      120

accctccggg aaggtgagca gttcgccaac gcattctttg acactgaaaa gaagatccaa      180

attgccaagg ctcttgacaa ctttggcgtg gattatatcg agctcacctc ccctgttgcc      240

tccgagcagt cccgacagga ttgcgaggct atttgcaaac ttggccttaa gtgcaagatc      300

ctcacccaca tcagatgcca catggacgat gctagagtcg ctgtcgagac cggagttgat      360

ggcgtcaacg ttgttattgg aacgtctcaa tatctccgaa agtactctca tggcaaggac      420

atgacctaca ttattgattc cgctacggag gttattaact ttgtcaagtc caaaggaatc      480

gaggtccgat tctcgtccga ggactccttc cgaagcgatc tcgtggacct cctttccctg      540

tacaaggccg ttgataagat cggagtcaac agagtcggca ttgccgacac cgtcggttgc      600

gccaccccac gacaggtgta tgatctcatc cgtaccctgc gtggcgtggt ctcctgtgat      660

atcgaatgcc actttcacaa cgacactggt atggccatcg ctaacgccta ctgcgccctc      720

gaggccggag caacccacat cgacacgtcc attctcggaa tcggcgaacg gaacggtatt      780

acaccactgg gagctctcct cgctcggatg tacgtcaccg accgggagta catcacacat      840

aagtacaagc tgaaccagct tcgagagctt gagaacctgg ttgctgacgc tgtcgaggtc      900

cagatcccct ttaataacta catcaccggc atgtgcgctt ttacccacaa agcaggtatt      960

catgccaaag caatcctggc taaccccagc acatacgaga ttctgaagcc cgaagacttc     1020

ggaatgtccc gttacgtcca cgtgggttcc cgactcacgg gctggaatgc tattaagtcc     1080

agagctgaac aactgaacct gcatcttacc gacgcccagg caaaggaact gaccgtccga     1140

atcaagaagc tggctgatgt gcgaactctg gccatggatg acgttgacag agttctgcga     1200

gaatatcacg ccgacctgtc tgatgctgat cgaattacta aggaagcctc cgcc           1254


<210>  106
<211>  2079
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  106
atgttgaggt caactacatt cactaggtct ttccactctt ccagagcctg gctgaaaggt       60

cagaatttga ccgaaaaaat agttcagagc tatgcggtta atttacccga aggtaaggtt      120

gtccattcag gagattatgt ttccattaaa cccgcccatt gcatgtctca tgataattct      180

tggccagttg ctcttaaatt tatgggtttg ggtgcaacga aaataaagaa cccctcacaa      240

atcgttacta ctctagatca tgacattcaa aataagtccg aaaaaaatct tactaagtac      300

aaaaatatag aaaactttgc aaaaaaacat catatcgatc attaccctgc gggtagaggt      360

ataggtcatc agatcatgat tgaagaagga tatgcgttcc ctttgaacat gactgttgcg      420

agcgactctc atagcaacac ttatggtggc ttgggatctt taggaacgcc aatcgtcaga      480

accgatgcgg ccgctatatg ggcaacaggg caaacatggt ggcagatccc ccctgtggcg      540

caagtggagc ttaagggtca attgccccaa ggtgtctccg gtaaagatat aatcgttgcc      600

ttatgcggtt tattcaataa tgatcaagtt ctgaaccatg ctattgaatt tactggagat      660

tctcttaatg cattgccaat agatcatagg ctaaccattg caaatatgac aacagaatgg      720

ggtgctctga gtggtttgtt tcctgtcgac aaaactttaa ttgattggta caaaaataga      780

ttgcaaaaat tgggaaccaa caaccatcca agaatcaatc caaaaactat cagggcccta      840

gaagaaaagg cgaagatccc taaagcagac aaggatgccc attatgctaa aaagcttata      900

atagaccttg caactttaac acattacgtg agtggtccaa acagcgtcaa ggtctctaat      960

acagtacaag atttgtccca gcaagatata aagataaaca aagcatatct tgtttcttgc     1020

acaaactctc gtttgtctga tttacaaagc gctgctgatg tagtctgccc tacaggtgac     1080

ttaaacaagg tgaataaagt ggctcccggt gtagaattct atgtggctgc tgcttcatca     1140

gaaatagagg cagatgcacg taaatctggt gcctgggaga aacttctaaa ggccggttgt     1200

atccctttac ctagtggctg cggaccatgt attgggcttg gagctggttt attggaaccg     1260

ggggaggtgg gaatctctgc cacaaataga aattttaaag gcagaatggg atcaaaggat     1320

gctctagctt atttggcctc ccccgcggta gttgcagcat ctgctgtttt gggaaaaatt     1380

agctcaccag ctgaggtctt gtctacttcc gagatccctt tttctggtgt gaaaacagag     1440

attatagaga accctgttgt agaagaggaa gtaaacgccc agactgaagc tcctaagcaa     1500

tctgttgaga ttttagaagg ttttcccaga gagttcagcg gggaattagt attgtgcgat     1560

gctgataata tcaatacaga cggcatctac cctggtaaat atacatatca agatgatgtc     1620

cccaaagaga aaatggccca agtatgcatg gagaactatg acgccgaatt taggaccaag     1680

gttcatcctg gtgacattgt cgtgtctggc tttaactttg gaaccggtag tagcagagaa     1740

caagccgcaa ctgcgttgtt ggcgaagggt atcaatttgg ttgtttcagg gagtttcggt     1800

aatatcttta gcaggaattc tatcaataat gctctgctta cacttgaaat accagcttta     1860

ataaaaaaac ttagagagaa gtatcagggt gcaccaaaag aacttaccag aagaaccggt     1920

tggttcttga agtgggacgt ggctgacgct aaagttgtag ttactgaagg ttctcttgat     1980

ggaccagtga tattggaaca aaaggtaggt gaattaggta aaaatctaca ggaaatcata     2040

gttaaaggcg gcttagaagg ttgggtgaaa tcacaatta                            2079


<210>  107
<211>  371
<212>  PRT
<213>  Ogataea parapolymorpha

<400>  107

Met Ala Ser Arg Thr Leu Ser Lys Gln Phe Ala Arg Thr Tyr Ala Thr 
1               5                   10                  15      


Lys Ala Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile Gly Arg Glu 
            20                  25                  30          


Val Ile Pro Ala Gly Lys Gln Val Leu Glu Ala Leu Pro Ser Asp Leu 
        35                  40                  45              


Gly Leu Lys Phe Glu Phe Thr Glu Leu Lys Ala Gly Phe Glu Leu Phe 
    50                  55                  60                  


Lys Gln Thr Gly Thr Ala Leu Pro Asp Glu Thr Val Glu Val Leu Gln 
65                  70                  75                  80  


Lys Ser Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser Pro Thr Thr 
                85                  90                  95      


Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala Leu Arg Lys Lys Leu 
            100                 105                 110         


Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu Gly Ile Gly 
        115                 120                 125             


Arg Pro Val Asp Met Val Ile Val Arg Glu Asn Thr Glu Asp Leu Tyr 
    130                 135                 140                 


Ile Lys Glu Glu Lys Leu Tyr Glu Lys Asp Gly Gln Lys Val Ala Glu 
145                 150                 155                 160 


Ala Ile Lys Arg Ile Thr Glu Arg Ala Thr Thr Lys Ile Gly Ala Ile 
                165                 170                 175     


Ala Leu Glu Ile Ala Leu Gln Arg Gln Ala Ile Arg Glu Leu Gly Gly 
            180                 185                 190         


Ala Ser Leu His Ser Gln Pro Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Val Ser Asp Gly Leu Phe Arg Glu Thr Val Arg Lys Leu 
    210                 215                 220                 


Tyr Asp Ser Asn Pro Ala Lys Tyr Ser Gly Val Gln Tyr Lys Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Met Phe Arg Glu Pro Glu Ile Phe 
                245                 250                 255     


Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Met Gly His Pro Glu Ala Ala Ser Lys Ile 
                325                 330                 335     


Tyr Ala Ala Val Asp Ala Asn Leu Lys Glu Asp Val Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ser Ser Thr Gln Glu Val Val Ala Asp Val Ile 
        355                 360                 365             


Arg Arg Leu 
    370     


<210>  108
<211>  1113
<212>  DNA
<213>  Ogataea parapolymorpha

<400>  108
atggcatcgc gcaccctctc caagcaattt gcacgcacct acgcaaccaa agctcttaag       60

atcggcctta tccctggcga cggcattggc cgcgaggtga ttcctgctgg taagcaggtg      120

ctcgaagctc tcccctcaga tctgggactc aagttcgaat tcacggagct taaggccgga      180

ttcgagctgt ttaaacaaac cggtaccgcc ctccctgatg aaactgtgga ggtcctccag      240

aaatcctgtg atggagcgct gttcggagcg gtctcctcgc ccaccactaa agttgagggc      300

tacagctctc caattgttgc actgcgtaag aagcttggcc tctacgctaa cgtacgtcca      360

gtgaaatccg ttgaaggcat cggtcgcccg gtggacatgg tcatcgtgcg ggagaacacc      420

gaagaccttt acattaagga agaaaaattg tatgaaaagg acggccagaa ggttgcagag      480

gcaatcaaac gaatcaccga acgcgccacc acaaaaatcg gtgccatcgc attggagatt      540

gcgcttcagc gacaagctat ccgcgagctc gggggtgcct ccctccacag ccagccaact      600

ctgaccgtga cccacaaatc aaatgtgttg tccgtgagcg atggtctttt ccgggagacg      660

gttcgtaagc tctacgattc taatccagct aagtatagcg gcgttcaata taaggaacaa      720

atcgtggatt ctatggtcta ccgcatgttc cgcgaacccg agattttcga tgtggttgtc      780

gcaccgaacc tctatggtga tatcctctca gacggagcag ctgcccttgt tggctccctg      840

ggtgtggtcc cctcggctaa cgttggagat aacttcgcaa tcggcgaacc gtgccacggt      900

agcgctccag acatcgaggg caagggaatc gcaaacccca tcgcgacgat ccggagcacc      960

gcacttatgc tcgaatttat gggccaccca gaggcggcgt caaagattta cgcggctgtt     1020

gatgccaacc tgaaagagga cgtaattaag accccagacc tgggtggaaa gtcctccacc     1080

caagaagttg tggcggacgt gattcggcga ctc                                  1113


<210>  109
<211>  1284
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  109
atgacagcag ccaagccgaa cccctatgca gccaagccag gagactactt atccaatgtt       60

aacaacttcc agttgatcga tagtacttta agggaaggtg aacaatttgc aaatgctttc      120

tttgacaccg aaaagaaaat tgaaattgca cgtgctctag atgactttgg cgttgattac      180

attgagttga catctccagt tgcctctgaa caatcaagaa aagactgcga agctatatgc      240

aagcttggcc tgaaagctaa aatattgacc cacattaggt gccacatgga cgacgctaaa      300

gttgcagtag agacgggcgt ggatggtgta gacgtagtga ttggaaccag taagttcttg      360

agacagtact cccacgggaa ggacatgaat tatattgcga agtctgctgt cgaagtcatt      420

gaatttgtca aatccaaggg gatagaaatt agattttcct ccgaagactc ctttagaagc      480

gatttagtag acttactgaa tatatacaag accgttgata agataggtgt caatcgtgtt      540

ggtattgctg atacggttgg ttgcgcgaat cccagacaag tctatgaatt gattcgtacc      600

ctgaaatccg tagtgtcctg tgatatagaa tgtcatttcc ataacgatac aggttgcgca      660

attgcaaacg catatacagc tcttgagggc ggtgctagat tgattgacgt atccgtcctt      720

ggaattggtg aaagaaacgg cattactcca ttgggcggat tgatggctcg tatgatagtc      780

gctgcccctg attatgtgaa gtccaagtac aagttacata aaattaggga tatcgaaaat      840

ttagtcgctg atgccgtgga agttaacatt ccattcaata atccgataac aggcttttgt      900

gcattcacgc ataaagcggg catacatgcc aaagctatat tagctaaccc tagcacctac      960

gaaattttag atccccatga ttttggtatg aaacgttaca tacatttcgc aaacagactt     1020

accggttgga acgcaataaa ggcaagagtt gaccagctta acctaaatct gactgacgac     1080

caaataaaag aagtgacagc taagattaaa aagctgggcg atgtaaggag tttgaacatt     1140

gatgacgtag atagtataat caagaacttt catgctgaag taagtactcc ccaagtattg     1200

tccgcaaaga aaaataagaa gaacgatagc gatgtgcctg aattggctac cataccagcc     1260

gctaaaagaa ccaaaccttc tgca                                            1284


<210>  110
<211>  1284
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  110
atgactgctg caaaaccgaa cccgtacgca gccaaaccgg gagattactt aagcaatgtt       60

aacaattttc agctcatcga tagtacttta cgcgaagggg agcaatttgc aaatgcgttt      120

ttcgatacgg aaaaaaaaat cgagatagcc cgtgcgttag atgattttgg cgtagactac      180

attgaactta cgtccccggt cgctagcgaa caaagccgga aagactgtga agccatttgc      240

aagcttgggc ttaaagcgaa aattcttacc catataagat gtcatatgga cgacgccaaa      300

gtcgcggttg agaccggtgt cgatggcgtc gatgttgtca tcggcacttc taagttttta      360

cgacaatatt cgcacggaaa agacatgaat tacatcgcaa agagtgcggt agaggtgata      420

gaatttgtaa aatcaaaagg gattgagatc cgtttctcaa gtgaggattc atttcgatcg      480

gatttggtgg atctgctgaa catatacaaa acggtcgata aaatcggcgt gaatagagtg      540

ggaatagccg atactgttgg ctgcgcaaat ccacgccaag tctacgaact tattcgcacg      600

ctcaaatcag tagtgtcatg cgacatagaa tgccattttc acaatgacac tggttgcgcg      660

attgcaaacg cttatacggc tttggaagga ggggctcgct taattgatgt gtcagtcctg      720

gggattggcg agcgcaatgg tattacgcca ttaggcgggc ttatggcacg catgatcgtt      780

gcggcgccgg actacgttaa atcgaaatat aaactgcata aaatccggga tatcgagaat      840

ttagtagccg atgctgtcga agtcaacatt ccatttaaca accctattac aggattttgc      900

gcatttacgc ataaggccgg catccacgcc aaagcaatct tggccaatcc ttcaacatat      960

gaaatattgg accctcacga ctttggtatg aagcgctata ttcattttgc gaatcgcctt     1020

acaggatgga atgctatcaa ggcgcgagtt gaccagctta accttaacct taccgacgat     1080

caaattaaag aagtaaccgc taagattaaa aaactgggag acgttcgatc cctgaatatc     1140

gacgacgtcg actccatcat caagaacttc cacgcagaag tgtctacgcc gcaggtcctc     1200

tcagctaaaa aaaataaaaa aaacgactct gatgttcctg aattagcaac aattccggca     1260

gctaagcgta caaagccgtc tgct                                            1284


<210>  111
<211>  2079
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  111
atgttaagaa gtacgacttt cacaagatcc tttcatagct cccgggcgtg gcttaaagga       60

cagaatctta ccgaaaaaat cgtccaatcg tacgccgtca atcttccgga gggtaaagtt      120

gtacattcag gagactacgt ttcaataaag ccggcacatt gtatgtctca tgacaattcc      180

tggcctgttg ctctgaagtt tatgggcctg ggggccacaa agattaagaa tccatcgcag      240

atcgtcacaa cattggatca tgacattcag aacaaatctg agaagaacct cacaaaatat      300

aaaaatatcg aaaactttgc aaaaaaacat catattgacc actatcctgc tgggagaggt      360

attggtcacc aaattatgat tgaggaggga tacgcgttcc cattaaatat gacggttgcg      420

tcagattctc atagcaatac ttacggtggc ctggggagtt tgggcacgcc gattgtgcgt      480

actgatgctg cggcaatttg ggcaacaggg caaacatggt ggcaaattcc accggttgcg      540

caggtcgagt tgaaaggcca gcttccgcaa ggagtgagcg gcaaagatat tatcgtcgca      600

ttgtgtggtc tctttaataa tgaccaggtc cttaatcacg ctatcgagtt tacaggagac      660

tcgctgaatg cactgcctat agatcatcgt ttaacaatcg caaatatgac aacagagtgg      720

ggagccctgt ctggcctgtt tccggtagat aaaactctta tcgattggta taaaaatcgt      780

ctgcagaagt taggtaccaa taaccatccg cgcattaatc ctaaaacaat tcgagcatta      840

gaagagaaag ccaaaattcc gaaggcagac aaggatgcgc attatgcgaa aaaactgatt      900

attgatttgg ccacattaac acattatgta tcggggccga actctgtaaa agtttccaat      960

acggtccaag atttatcaca acaagacatc aaaatcaaca aggcatatct ggttagctgc     1020

accaatagcc gattatccga tctgcaaagc gcggccgatg ttgtatgtcc aacaggtgat     1080

ctcaataagg taaataaagt cgctccggga gtagaattct acgtggccgc cgcttccagt     1140

gagatcgaag cggacgccag aaaatcagga gcttgggaaa aactcttaaa agccggctgt     1200

attcctctgc cgtctggctg cgggccatgc atcggattag gggcgggcct cctcgaaccg     1260

ggcgaggtcg gcatctcagc tacaaatcgc aattttaaag gccgtatggg aagcaaagac     1320

gccttagctt atttggcttc tccagctgtt gtcgcagcat cagcagtcct gggaaagatt     1380

tcttctcctg cagaagtatt atccacatca gaaattccgt tttctggggt aaaaaccgaa     1440

attatagaaa atccggtggt cgaggaagag gttaatgcgc agaccgaggc tcctaaacag     1500

tctgtggaaa tccttgaagg atttccgaga gaatttagtg gggaattagt gctgtgtgat     1560

gctgataaca ttaataccga tggcatctac ccgggcaagt atacttacca ggacgacgtg     1620

cctaaagaga aaatggcaca agtttgcatg gagaactacg atgctgaatt cagaacgaag     1680

gtgcatccgg gcgatatcgt tgtctctgga tttaatttcg gtacgggctc gtccagagag     1740

caggccgcaa cggcacttct tgccaaaggc attaatctgg ttgtcagcgg ttcttttggc     1800

aatattttct cacgtaactc aatcaacaat gctctcctta ctcttgaaat cccggcactt     1860

attaaaaaac tccgtgagaa atatcaaggc gctccaaagg aacttacaag acgtacaggt     1920

tggttcctta aatgggatgt tgccgatgcg aaagtggttg tcacggaagg atcccttgac     1980

gggccggtca ttctggaaca aaaggtcggt gagctcggaa aaaatcttca ggagattatt     2040

gttaaaggcg gcttagaagg ctgggttaaa tcacaattg                            2079


<210>  112
<211>  1128
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  112
atgcgtgagt ggaagatcat cgactcgacc ctgcgagaag gagagcagtt cgagaaggcc       60

aacttctcta cccaggacaa ggttgagatt gctaaggccc tggacgagtt cggaattgag      120

tacattgagg tcactacacc tgtcgcctcg ccccagagcc gtaaggacgc tgaggtgctg      180

gcctctctcg gcctcaaggc taaggtggtt acccacatcc agtgtagact tgatgctgca      240

aaggtcgccg tcgagactgg cgtgcaggga atcgacctcc tcttcggtac gagcaaatac      300

cttcgagccg cccatggacg agacatccct cgaatcattg aggaggccaa ggaagtgatt      360

gcctacatta gagaagctgc accccatgtg gaggtccgtt tttccgctga ggatactttc      420

cgatctgagg agcaggatct tcttgctgtc tacgaggccg tggcccccta tgtcgacaga      480

gtgggcctgg ctgacaccgt gggtgtggct acgccacgtc aggtctacgc cctggtccga      540

gaggtgcgaa gagttgtcgg cccccgggtg gacatcgagt ttcatggaca taacgacacg      600

ggctgtgcta ttgctaacgc ttatgaagca attgaagctg gcgccaccca cgtggatacc      660

actatcctcg gaattggaga acgtaacggc atcacacccc tgggtggttt ccttgcacga      720

atgtataccc tccaacccga gtacgtgcga cgtaagtaca agctcgaaat gctccccgag      780

ctggacagaa tggttgctcg aatggtcgga gtggaaattc ccttcaacaa ctacatcacc      840

ggcgagaccg cctttagcca caaggctggc atgcacctga aagctatcta tatcaatccc      900

gaggcatatg agccttaccc ccccgaggtt ttcggcgtga agcgaaaact gatcatcgca      960

tcgcggctga caggtagaca tgccatcaaa gcacgtgccg aggaactggg tctccattac     1020

ggagaggagg agctccatcg agtcacccag cacatcaagg ccctggccga cagaggtcag     1080

ctcaccctgg aggagctgga ccgaatcctg cgagagtgga ttaccgct                  1128


<210>  113
<211>  2052
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  113
atgttccatt cgtcacgcgc atggttaaaa ggtcaaaatc tgaccgaaaa aattgtgcag       60

agctatgcag taaacttacc tgaagggaaa gttgtccata gcggcgatta cgtatcaatt      120

aaaccagcac attgcatgag ccatgacaat tcttggccgg tggccttaaa gtttatgggg      180

ctgggggcaa ccaaaattaa aaaccctagc cagattgtta ccacgcttga tcacgacatc      240

cagaacaaaa gcgaaaaaaa cctgaccaaa tataagaaca ttgagaattt tgcgaaaaaa      300

catcacattg atcactatcc agcgggtcgc ggaatcggcc accaaattat gattgaggaa      360

ggttatgctt ttcctcttaa tatgaccgtt gctagtgact cacattcaaa tacatatggc      420

gggctggggt cactgggcac accgatagtt cgtaccgatg cagccgcgat ttgggctaca      480

gggcaaacat ggtggcaaat ccctccagta gcccaagttg agcttaaggg gcaattacct      540

cagggagtct caggcaaaga cattatcgta gctttatgcg gtctgttcaa taatgatcaa      600

gtacttaacc atgccattga attcaccggc gacagcctca acgcacttcc tattgaccat      660

cggctgacaa tcgccaacat gacgacggag tggggagcat tgtcaggact gtttccggtt      720

gacaagactc ttatcgactg gtacaaaaat cgccttcaaa aattaggaac taataaccat      780

ccacggatca atccgaaaac tatcagagcg ttggaagaaa aagcgaaaat tccgaaagct      840

gataaagatg cccattacgc taagaaattg atcattgatc tggctacttt gacccattat      900

gtgtcaggac ctaactcagt aaaagtctca aatacagttc aggatttatc tcagcaagac      960

atcaagatca ataaggcata cctggttagc tgcactaatt cacggttgtc tgatcttcaa     1020

tctgcagcgg acgtagtttg ccctacggga gatctgaata aagtaaacaa agtagctccg     1080

ggcgtggaat tttatgtagc ggctgcgagc agcgagattg aagctgacgc acgcaagtcg     1140

ggtgcctggg agaaactttt gaaagccgga tgtataccgt tgccgtccgg gtgtggacct     1200

tgtatcggat taggcgcagg gctgctcgaa cctggcgaag tagggatctc agctacgaac     1260

agaaatttta aaggacgtat gggaagcaaa gacgcgctgg cctatttagc cagtcctgcg     1320

gtcgtcgcag caagcgcagt tctcgggaaa atctctagtc cagcagaagt attgagcaca     1380

agcgaaattc ctttttctgg agtaaagacg gaaattatcg aaaacccagt tgttgaagaa     1440

gaggttaatg cccagacaga agcgccgaag caatccgtag agattctcga aggttttcct     1500

cgcgaatttt ctggagaact tgtactgtgt gacgcggaca atattaacac agatgggata     1560

tatccgggaa aatatactta tcaagacgat gtacctaagg aaaagatggc acaggtatgt     1620

atggagaatt atgacgccga atttcgaact aaagtacacc ctggcgatat cgtcgtgtca     1680

ggctttaact ttggaaccgg cagctctcgg gagcaggctg cgacagcgct gctggccaaa     1740

ggaatcaacc ttgtcgtctc tggctctttc ggaaatatat tcagccggaa ctccattaat     1800

aacgcgcttt tgaccctgga aattcctgca ttgatcaaaa agttgcggga aaaatatcaa     1860

ggagccccta aagaacttac ccgacggacg ggatggttcc ttaaatggga cgtcgcggac     1920

gcgaaagtgg tagttacgga gggttcactc gatgggcctg tgatccttga gcagaaagtt     1980

ggtgaattag gcaagaatct tcaggaaata attgtgaaag gtggcctgga gggctgggta     2040

aagagtcagc tg                                                         2052


<210>  114
<211>  2331
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  114
atgttcaaaa gaaccggctc attgttgtta agatgtagag catcaagagt acctgttata       60

ggtagacctt tgatttcatt gagcacatcc tctacgagtc tttctttgag tcgtcccaga      120

agtttcgcca ccaccagctt gagaaggtat actgaagcaa gctcctctac gactcaaaca      180

tctccatcat ctagttcttg gccagcaccc gacgctgcac ccagggtacc acagactctt      240

acagaaaaaa ttgtgcaggc ttactcactt ggtttggccg aaggtcaata cgttaaggca      300

ggagattacg ttatgttgtc cccacataga tgtatgaccc atgataactc ttggccaaca      360

gcattgaagt tcatggccat tggagcatct aaggttcata accccgacca gatagtcatg      420

accttagatc atgatgtcca aaataaatct gaaaaaaatc taaagaaata cgaaagcata      480

gaaaaattcg ccaagcagca tggtatagac ttttatcctg ctggacatgg cgttggccac      540

caaatcatga tcgaagaggg ctacgcattt cccgggaccg ttacagtggc gtctgattct      600

cactcaaata tgtatggagg ggtggggtgc ttgggcaccc ccatggtaag gactgatgcc      660

gccaccatct gggccaccgg aagaacatgg tggaaagtgc ctccaatcgc aaaagtccaa      720

ttcacgggca cacttccaga aggtgttacc ggaaaggatg tgattgtagc attatctggc      780

cttttcaata aagacgaagt tttgaactac gctatcgagt ttacaggttc agaagaaact      840

atgaagtctt tgtcagtaga cactcgtctt acaattgcga atatgacgac agaatggggt      900

gctttgacgg gcttgttccc tattgattct acattagagc agtggctgag acataaagct      960

gcaactgcgt ctagaaccga aacagccaga agattcgccg aagaaagaat aaacgaatta     1020

ttcgccaacc caacggttgc tgatcgtggt gctagatacg ccaaatactt gtatttagat     1080

ttgtctactt tgtctcctta tgttagtggt ccaaactcag tcaaagtcgc taccccattg     1140

gatgagctag aaaagcataa gttaaagatc gacaaagcat accttgttag ctgtacaaac     1200

tcaagggctt ctgatatcgc ggcagctgcc aaggtcttca aggatgccgt tgcaaggaca     1260

gggggtcctg tcagagtcgc agatggggtg gaattttacg tggcagctgc ttccaaggcc     1320

gagcagaaaa ttgcagagga agctggggat tggcaagctt tgatggacgc tggggcaatt     1380

ccattaccgg caggctgtgc tgtttgcatt ggtctgggcg ctggtttatt aaaggaaggt     1440

gaagtgggta tatcagcctc caacagaaat tttaaaggcc gtatgggttc tccagatgcg     1500

aaggcttatc tagcctctcc ggaggtggtt gctgccagtg cattgaacgg ggttatctca     1560

ggtccgggca tctacaagag accagaggac tggacaggag tatcaatcgg agaaggcgaa     1620

gttgttgaat ctggatctag aatagacact actttagagg caatggaaaa gtttattgga     1680

caattagata gcatgattga ctcctccagc aaagctgtta tgccagaaga atcaacaggt     1740

tctggcgcta cagaagttga tattgttcct ggtttccccg aaaaaatcga aggcgaaata     1800

ttgtttttgg acgcggataa tatctcaacc gatggaattt atccaggaaa gtacacctac     1860

caagacgacg ttacaaaaga caaaatggct caagtttgca tggaaaacta cgatccagct     1920

ttctccggta tagcaagggc tggagacatt tttgtttcag gtttcaactt tggttgtggc     1980

tcaagcagag aacaggctgc tacatctatt ttggctaagc agttgccttt agttgtagca     2040

ggaagtattg ggaatacttt ttccagaaac gcagttaaca atgcgttgcc gttgttagaa     2100

atgccaagat taattgaaag actgagagaa gcattcggtt cagaaaaaca gcctacaaga     2160

agaacaggat ggacttttac ttggaacgtt aggacttctc aagtgacggt acaggaaggg     2220

cctggcggtg agacctggtc tcaatcagtt ccggctttcc ctccaaattt acaggatatt     2280

attgctcagg gaggtttaga aaaatgggtt aaaaaagaga tatctaaggc a              2331


<210>  115
<211>  1128
<212>  DNA
<213>  Thermus thermophilus

<400>  115
atgcgggaat ggaagattat tgactcgacg cttcgcgaag gtgaacagtt tgagaaagcg       60

aatttcagca ctcaagataa ggttgaaatc gccaaggctt tggatgagtt tggcattgag      120

tatatcgagg taacgacccc cgtggcaagc ccccaatctc ggaaggatgc agaggtgctc      180

gcctctctcg gactcaaggc gaaagtcgtg actcatattc aatgccgtct cgacgccgct      240

aaggtggctg ttgaaacggg agttcaaggc attgatctgc ttttcggtac ctctaaatac      300

ctccgcgcgg cgcacggacg ggatattccg cggattatcg aggaagctaa agaggtcatt      360

gcgtacattc gcgaagctgc gccacatgta gaagtgcgct tctccgcgga agacacgttc      420

cggtctgagg aacaggattt gctcgctgtt tatgaagcgg tggcccccta cgttgatcgt      480

gtgggacttg cggatacggt tggagttgct acgcctcgcc aagtatatgc ccttgtacgc      540

gaagttcggc gcgtggtggg tccacgggtg gatattgaat tccacggcca taatgatact      600

ggttgcgcca tcgccaacgc ttatgaagcg atcgaggccg gcgcaactca cgttgacacg      660

actattctgg gtattggcga acggaacgga attactccgc ttggaggttt tctcgctcgg      720

atgtacacgc ttcaaccgga atatgtacgc cggaagtaca agctggaaat gctgcctgag      780

ctggatcgta tggtggcgcg catggtcgga gttgagatcc cattcaataa ttacattacc      840

ggagaaaccg ctttttcgca caaagctgga atgcatctga aagccattta catcaatccc      900

gaggcatacg aaccgtaccc cccagaagtc ttcggtgtca agcggaaact cattattgca      960

agccgtctta cgggccggca cgctattaaa gcgcgtgcgg aggagcttgg attgcattac     1020

ggagaagagg aactccaccg tgtaacgcaa cacatcaaag ctctcgcaga ccgtggccaa     1080

ttgactctcg aagaattgga ccgtattctg cgggaatgga tcaccgca                  1128


<210>  116
<211>  376
<212>  PRT
<213>  Thermus thermophilus

<400>  116

Met Arg Glu Trp Lys Ile Ile Asp Ser Thr Leu Arg Glu Gly Glu Gln 
1               5                   10                  15      


Phe Glu Lys Ala Asn Phe Ser Thr Gln Asp Lys Val Glu Ile Ala Lys 
            20                  25                  30          


Ala Leu Asp Glu Phe Gly Ile Glu Tyr Ile Glu Val Thr Thr Pro Val 
        35                  40                  45              


Ala Ser Pro Gln Ser Arg Lys Asp Ala Glu Val Leu Ala Ser Leu Gly 
    50                  55                  60                  


Leu Lys Ala Lys Val Val Thr His Ile Gln Cys Arg Leu Asp Ala Ala 
65                  70                  75                  80  


Lys Val Ala Val Glu Thr Gly Val Gln Gly Ile Asp Leu Leu Phe Gly 
                85                  90                  95      


Thr Ser Lys Tyr Leu Arg Ala Ala His Gly Arg Asp Ile Pro Arg Ile 
            100                 105                 110         


Ile Glu Glu Ala Lys Glu Val Ile Ala Tyr Ile Arg Glu Ala Ala Pro 
        115                 120                 125             


His Val Glu Val Arg Phe Ser Ala Glu Asp Thr Phe Arg Ser Glu Glu 
    130                 135                 140                 


Gln Asp Leu Leu Ala Val Tyr Glu Ala Val Ala Pro Tyr Val Asp Arg 
145                 150                 155                 160 


Val Gly Leu Ala Asp Thr Val Gly Val Ala Thr Pro Arg Gln Val Tyr 
                165                 170                 175     


Ala Leu Val Arg Glu Val Arg Arg Val Val Gly Pro Arg Val Asp Ile 
            180                 185                 190         


Glu Phe His Gly His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala Tyr 
        195                 200                 205             


Glu Ala Ile Glu Ala Gly Ala Thr His Val Asp Thr Thr Ile Leu Gly 
    210                 215                 220                 


Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Phe Leu Ala Arg 
225                 230                 235                 240 


Met Tyr Thr Leu Gln Pro Glu Tyr Val Arg Arg Lys Tyr Lys Leu Glu 
                245                 250                 255     


Met Leu Pro Glu Leu Asp Arg Met Val Ala Arg Met Val Gly Val Glu 
            260                 265                 270         


Ile Pro Phe Asn Asn Tyr Ile Thr Gly Glu Thr Ala Phe Ser His Lys 
        275                 280                 285             


Ala Gly Met His Leu Lys Ala Ile Tyr Ile Asn Pro Glu Ala Tyr Glu 
    290                 295                 300                 


Pro Tyr Pro Pro Glu Val Phe Gly Val Lys Arg Lys Leu Ile Ile Ala 
305                 310                 315                 320 


Ser Arg Leu Thr Gly Arg His Ala Ile Lys Ala Arg Ala Glu Glu Leu 
                325                 330                 335     


Gly Leu His Tyr Gly Glu Glu Glu Leu His Arg Val Thr Gln His Ile 
            340                 345                 350         


Lys Ala Leu Ala Asp Arg Gly Gln Leu Thr Leu Glu Glu Leu Asp Arg 
        355                 360                 365             


Ile Leu Arg Glu Trp Ile Thr Ala 
    370                 375     


<210>  117
<211>  1128
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  117
atgcgcgaat ggaagattat cgacagtacg ctccgtgagg gtgaacaatt tgaaaaggcg       60

aacttttcaa cgcaggacaa agtggagata gcaaaagctt tggacgaatt tggcatagaa      120

tatatcgaag tcacaacacc ggtagcgtct ccgcagagcc gcaaggatgc agaagtatta      180

gctagcctcg gattaaaagc taaggttgtt acacatattc aatgccggct ggacgcggcg      240

aaggttgcgg tggaaaccgg tgttcaaggc attgatctgc tttttggcac aagtaagtac      300

cttagagctg ctcatggccg tgatatccca cgtatcatcg aagaagccaa agaagtcatc      360

gcatatatta gagaggcggc tccgcatgtt gaagttcgtt tttctgctga ggatacattc      420

cgttccgaag aacaggatct tctggctgtc tatgaagcgg ttgcgcctta cgtggaccgt      480

gtgggtctgg cggatactgt tggtgttgca acaccgcgcc aggtatatgc gctggtccgt      540

gaagttagac gcgtcgtagg cccgcgtgtt gacatcgaat ttcatggcca caatgatacc      600

ggctgcgcaa tcgcaaacgc ttatgaagca atagaagcgg gcgcgacgca tgtggatacc      660

acaattctcg ggattggtga acgcaacggc ataacaccac ttggcggatt tctcgcccgg      720

atgtatactt tgcaaccgga atacgttaga agaaaatata aactggagat gctcccggag      780

ttagatcgta tggttgctcg tatggttggc gtcgaaattc cgtttaacaa ctatattaca      840

ggagagacag cgttttctca taaagcgggt atgcacctga aagccatcta tatcaatccg      900

gaagcatacg aaccgtatcc gccggaggtg ttcggggtga agagaaaatt gatcattgcg      960

tctagactta cgggccgcca tgccattaaa gcacgcgctg aggagctggg gttacattac     1020

ggcgaagaag aacttcatag agtcacgcag catatcaaag ccttggcaga tagaggacag     1080

ttgacgctgg aagaattaga tcggatttta agagaatgga ttacggct                  1128


<210>  118
<211>  1128
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  118
atgcgtgaat ggaaaattat tgactctacg ctgcgtgagg gtgagcaatt tgaaaaagca       60

aatttctcca cccaggataa ggtggaaatc gccaaggcgc tggatgaatt tggtatcgag      120

tacatcgaag tgactactcc cgtggcatcc ccacagtctc gaaaggacgc cgaagtgttg      180

gcttccctcg gccttaaggc caaggtcgtt acccacatcc agtgccgtct cgatgccgcc      240

aaggtggcgg ttgagactgg cgttcaggga atcgacttgt tgttcggaac cagcaaatac      300

ttgcgagctg ctcatggccg cgatattcca cgcattattg aagaggcaaa agaagtgatt      360

gcatacatcc gagaagctgc tccccatgta gaagtccgct tctcggctga agacaccttc      420

cgttcagaag agcaagacct tttggctgta tacgaggctg ttgctccgta cgtggatcgc      480

gtcggtttgg cagacaccgt gggcgtggcc accccacgcc aggtatatgc cttggttcgt      540

gaggttcgtc gcgtagtagg cccacgtgta gacatcgaat tccatggtca caacgataca      600

ggttgtgcca tcgctaacgc atacgaggcc atcgaagcag gcgctaccca cgtcgacacc      660

acaatcttgg gcatcggcga acgtaatggt atcaccccat tgggtggctt cctggctcgc      720

atgtacactc ttcaacctga atacgtgcgc cgcaagtaca agttggaaat gttgcctgaa      780

ctggatcgta tggttgcccg catggtggga gtcgaaatcc ccttcaacaa ttacatcact      840

ggcgaaacgg ctttctccca caaggctgga atgcacctga aagcaatcta catcaatcca      900

gaggcgtatg agccataccc accggaagtg tttggcgtta agcgaaaact tattattgcc      960

agccgactca ccggccgtca cgcaatcaag gctcgcgccg aagagctcgg tctccattac     1020

ggcgaagagg agcttcatcg cgttacccag cacatcaaag cactcgctga ccgcggccag     1080

ctgacccttg aagaactgga tcgcattctg cgcgaatgga tcacggcg                  1128


<210>  119
<211>  1002
<212>  DNA
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  119
atggcctacc gtatctgctt gattgaaggt gatggtattg gtcatgaggt aattcctgct       60

gccagaagag ttttggaggc aactggtcta cctttggaat tcgtcgaagc tgaggctggt      120

tgggaaacat ttgaaaggag aggtacttca gtacccgaag aaacagttga gaaaatctta      180

agctgtcatg ctaccttatt tggtgcagct acatccccca caagaaaggt acccggcttt      240

ttcggcgcga tcagatattt gaggaggaga ctagacttat atgcgaacgt aagacctgcg      300

aagtcaagac ctgtccctgg ttcaagacct ggcgttgatc ttgtaattgt aagggagaac      360

actgaaggtt tgtacgtcga gcaagaaagg agatacctag acgtagcaat tgccgatgct      420

gttataagca aaaaggctag tgagcgtatt ggaagagccg cgctaagaat tgcagaagga      480

agacccagaa aaacgttgca tatcgcacat aaagcgaacg tgttaccgtt aactcaaggc      540

ctatttttgg atacagttaa agaagtcgct aaagatttcc cccttgttaa tgttcaagac      600

attatagttg acaattgcgc tatgcagttg gtaatgaggc ctgaaagatt tgatgtaatc      660

gttactacta acctgctggg cgacatattg agtgacctag cagctggctt agttggtgga      720

ttaggtctgg ctccatcagg aaatataggt gatactactg ctgtttttga acccgtgcat      780

ggttcagcac ctgacatagc tggaaagggt atcgcgaacc caactgcggc tattctgtct      840

gctgccatga tgttggacta tctaggtgaa aaagaagctg ccaagagagt tgaaaaggcc      900

gtagatttgg tgttagaaag aggtccgaga actcctgatc taggtggaga tgctacgaca      960

gaagccttca cagaggcagt cgtagaagct ttgaaatcac ta                        1002


<210>  120
<211>  435
<212>  PRT
<213>  Komagataella pastoris

<400>  120

Met Ser Glu Thr Asn Gly Gln Thr Asn Gly Ser Ser Asn Gly Ala Gln 
1               5                   10                  15      


Pro Gln Gln Arg Asn Pro Tyr Gly Pro His Pro Ser Asp Phe Leu Ser 
            20                  25                  30          


Asn Val Ser Ser Phe Gln Leu Ile Glu Ser Thr Leu Arg Glu Gly Glu 
        35                  40                  45              


Gln Phe Ala Asn Ala Phe Phe Thr Thr Glu Lys Lys Ile Glu Ile Ala 
    50                  55                  60                  


Lys Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro 
65                  70                  75                  80  


Val Ala Ser Glu Gln Ser Arg Ser Asp Cys Glu Ala Ile Cys Lys Leu 
                85                  90                  95      


Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg Cys His Met Asp Asp 
            100                 105                 110         


Ala Arg Val Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val Ile 
        115                 120                 125             


Gly Thr Ser Gln Phe Leu Arg Gln Phe Ser His Gly Lys Asp Met Ser 
    130                 135                 140                 


Tyr Ile Thr Asn Gln Ala Ile Glu Val Ile Glu Phe Val Lys Ser Lys 
145                 150                 155                 160 


Gly Ile Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Ile 
                165                 170                 175     


Val Asp Leu Leu Asn Ile Tyr Arg Thr Val Asp Lys Ile Gly Val Asn 
            180                 185                 190         


Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Asn Pro Arg Gln Val 
        195                 200                 205             


Tyr Glu Leu Val Lys Thr Leu Lys Ser Val Val His Cys Asp Ile Glu 
    210                 215                 220                 


Cys His Phe His Asp Asp Thr Gly Cys Ala Ile Ala Asn Ala Tyr Thr 
225                 230                 235                 240 


Ala Leu Glu Ala Gly Ala Lys Leu Ile Asp Val Ser Val Leu Gly Ile 
                245                 250                 255     


Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met Ala Arg Met 
            260                 265                 270         


Ile Ala Ala Asp Arg Asp Tyr Val Leu Ser Lys Tyr Lys Leu His Lys 
        275                 280                 285             


Leu Arg Asp Leu Glu Thr Leu Val Ala Glu Ala Val Gln Val Asn Ile 
    290                 295                 300                 


Pro Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe Thr His Lys Ala 
305                 310                 315                 320 


Gly Ile His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu Ile 
                325                 330                 335     


Leu Gln Pro Ser Asp Phe Gly Leu Thr Arg Tyr Ile His Phe Ala Asn 
            340                 345                 350         


Arg Leu Thr Gly Trp Asn Ala Ile Lys Ser Arg Val Asp Gln Leu Asn 
        355                 360                 365             


Leu His Leu Thr Asp Ala Gln Cys Lys Glu Val Thr Ala Lys Ile Lys 
    370                 375                 380                 


Lys Met Gly Asp Ile Arg Pro Leu Asn Ile Asp Asp Val Asp Ser Ile 
385                 390                 395                 400 


Ile Lys Asp Phe His Ala Asp Ile Thr Thr Pro Ala Phe Pro Pro Val 
                405                 410                 415     


Ala Thr Asn Asn Asp Glu Asp Val Glu Pro Ala Thr Lys Lys Gln Arg 
            420                 425                 430         


Leu Asp Gln 
        435 


<210>  121
<211>  1305
<212>  PRT
<213>  Artificial

<220>
<223>  mutated or codon-optimized sequence

<400>  121

Ala Thr Gly Thr Cys Gly Gly Ala Ala Ala Cys Gly Ala Ala Thr Gly 
1               5                   10                  15      


Gly Thr Cys Ala Gly Ala Cys Gly Ala Ala Thr Gly Gly Ala Ala Gly 
            20                  25                  30          


Cys Thr Cys Ala Ala Ala Thr Gly Gly Ala Gly Cys Cys Cys Ala Gly 
        35                  40                  45              


Cys Cys Gly Cys Ala Ala Cys Ala Gly Cys Gly Cys Ala Ala Thr Cys 
    50                  55                  60                  


Cys Gly Thr Ala Cys Gly Gly Thr Cys Cys Ala Cys Ala Cys Cys Cys 
65                  70                  75                  80  


Cys Ala Gly Cys Gly Ala Thr Thr Thr Cys Cys Thr Cys Ala Gly Cys 
                85                  90                  95      


Ala Ala Thr Gly Thr Thr Thr Cys Cys Ala Gly Cys Thr Thr Thr Cys 
            100                 105                 110         


Ala Gly Cys Thr Gly Ala Thr Thr Gly Ala Gly Ala Gly Cys Ala Cys 
        115                 120                 125             


Thr Cys Thr Gly Cys Gly Thr Gly Ala Gly Gly Gly Ala Gly Ala Gly 
    130                 135                 140                 


Cys Ala Ala Thr Thr Thr Gly Cys Gly Ala Ala Thr Gly Cys Gly Thr 
145                 150                 155                 160 


Thr Cys Thr Thr Thr Ala Cys Cys Ala Cys Thr Gly Ala Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Thr Thr Gly Ala Ala Ala Thr Thr Gly Cys Gly 
            180                 185                 190         


Ala Ala Gly Gly Cys Gly Thr Thr Gly Gly Ala Thr Gly Ala Cys Thr 
        195                 200                 205             


Thr Thr Gly Gly Ala Gly Thr Thr Gly Ala Thr Thr Ala Thr Ala Thr 
    210                 215                 220                 


Cys Gly Ala Ala Cys Thr Gly Ala Cys Cys Thr Cys Ala Cys Cys Thr 
225                 230                 235                 240 


Gly Thr Cys Gly Cys Ala Thr Cys Cys Gly Ala Ala Cys Ala Gly Thr 
                245                 250                 255     


Cys Ala Cys Gly Thr Thr Cys Ala Gly Ala Cys Thr Gly Thr Gly Ala 
            260                 265                 270         


Gly Gly Cys Cys Ala Thr Cys Thr Gly Thr Ala Ala Ala Cys Thr Gly 
        275                 280                 285             


Gly Gly Ala Cys Thr Thr Ala Ala Ala Gly Cys Cys Ala Ala Ala Ala 
    290                 295                 300                 


Thr Thr Cys Thr Thr Ala Cys Thr Cys Ala Thr Ala Thr Cys Cys Gly 
305                 310                 315                 320 


Thr Thr Gly Cys Cys Ala Thr Ala Thr Gly Gly Ala Cys Gly Ala Cys 
                325                 330                 335     


Gly Cys Thr Cys Gly Thr Gly Thr Gly Gly Cys Cys Gly Thr Cys Gly 
            340                 345                 350         


Ala Ala Ala Cys Thr Gly Gly Ala Gly Thr Cys Gly Ala Thr Gly Gly 
        355                 360                 365             


Cys Gly Thr Gly Gly Ala Cys Gly Thr Gly Gly Thr Cys Ala Thr Thr 
    370                 375                 380                 


Gly Gly Ala Ala Cys Cys Thr Cys Thr Cys Ala Ala Thr Thr Cys Cys 
385                 390                 395                 400 


Thr Gly Cys Gly Thr Cys Ala Gly Thr Thr Thr Ala Gly Cys Cys Ala 
                405                 410                 415     


Thr Gly Gly Cys Ala Ala Gly Gly Ala Thr Ala Thr Gly Ala Gly Cys 
            420                 425                 430         


Thr Ala Thr Ala Thr Cys Ala Cys Thr Ala Ala Thr Cys Ala Gly Gly 
        435                 440                 445             


Cys Thr Ala Thr Thr Gly Ala Gly Gly Thr Gly Ala Thr Cys Gly Ala 
    450                 455                 460                 


Ala Thr Thr Thr Gly Thr Ala Ala Ala Ala Thr Cys Ala Ala Ala Ala 
465                 470                 475                 480 


Gly Gly Ala Ala Thr Thr Gly Ala Ala Ala Thr Thr Cys Gly Cys Thr 
                485                 490                 495     


Thr Cys Thr Cys Thr Thr Cys Cys Gly Ala Ala Gly Ala Cys Thr Cys 
            500                 505                 510         


Gly Thr Thr Cys Cys Gly Thr Thr Cys Thr Gly Ala Cys Ala Thr Thr 
        515                 520                 525             


Gly Thr Cys Gly Ala Thr Cys Thr Gly Cys Thr Thr Ala Ala Thr Ala 
    530                 535                 540                 


Thr Thr Thr Ala Cys Cys Gly Thr Ala Cys Thr Gly Thr Thr Gly Ala 
545                 550                 555                 560 


Thr Ala Ala Gly Ala Thr Thr Gly Gly Thr Gly Thr Cys Ala Ala Thr 
                565                 570                 575     


Cys Gly Gly Gly Thr Ala Gly Gly Cys Ala Thr Cys Gly Cys Ala Gly 
            580                 585                 590         


Ala Thr Ala Cys Thr Gly Thr Thr Gly Gly Cys Thr Gly Cys Gly Cys 
        595                 600                 605             


Thr Ala Ala Thr Cys Cys Thr Cys Gly Gly Cys Ala Gly Gly Thr Ala 
    610                 615                 620                 


Thr Ala Thr Gly Ala Gly Cys Thr Thr Gly Thr Thr Ala Ala Gly Ala 
625                 630                 635                 640 


Cys Cys Cys Thr Gly Ala Ala Gly Ala Gly Cys Gly Thr Ala Gly Thr 
                645                 650                 655     


Cys Cys Ala Thr Thr Gly Thr Gly Ala Thr Ala Thr Thr Gly Ala Gly 
            660                 665                 670         


Thr Gly Cys Cys Ala Cys Thr Thr Cys Cys Ala Thr Gly Ala Thr Gly 
        675                 680                 685             


Ala Thr Ala Cys Thr Gly Gly Cys Thr Gly Cys Gly Cys Cys Ala Thr 
    690                 695                 700                 


Cys Gly Cys Cys Ala Ala Cys Gly Cys Cys Thr Ala Cys Ala Cys Gly 
705                 710                 715                 720 


Gly Cys Cys Cys Thr Cys Gly Ala Ala Gly Cys Ala Gly Gly Ala Gly 
                725                 730                 735     


Cys Gly Ala Ala Ala Thr Thr Gly Ala Thr Thr Gly Ala Cys Gly Thr 
            740                 745                 750         


Ala Thr Cys Thr Gly Thr Thr Thr Thr Gly Gly Gly Thr Ala Thr Thr 
        755                 760                 765             


Gly Gly Thr Gly Ala Gly Cys Gly Cys Ala Ala Cys Gly Gly Thr Ala 
    770                 775                 780                 


Thr Cys Ala Cys Gly Cys Cys Thr Cys Thr Gly Gly Gly Cys Gly Gly 
785                 790                 795                 800 


Thr Thr Thr Gly Ala Thr Gly Gly Cys Cys Cys Gly Gly Ala Thr Gly 
                805                 810                 815     


Ala Thr Thr Gly Cys Cys Gly Cys Ala Gly Ala Cys Cys Gly Gly Gly 
            820                 825                 830         


Ala Thr Thr Ala Thr Gly Thr Cys Cys Thr Thr Ala Gly Cys Ala Ala 
        835                 840                 845             


Gly Thr Ala Cys Ala Ala Gly Cys Thr Cys Cys Ala Thr Ala Ala Gly 
    850                 855                 860                 


Cys Thr Gly Cys Gly Thr Gly Ala Cys Cys Thr Thr Gly Ala Ala Ala 
865                 870                 875                 880 


Cys Gly Cys Thr Cys Gly Thr Cys Gly Cys Gly Gly Ala Ala Gly Cys 
                885                 890                 895     


Ala Gly Thr Thr Cys Ala Gly Gly Thr Thr Ala Ala Cys Ala Thr Cys 
            900                 905                 910         


Cys Cys Cys Thr Thr Thr Ala Ala Cys Ala Ala Cys Cys Cys Cys Ala 
        915                 920                 925             


Thr Cys Ala Cys Cys Gly Gly Cys Thr Thr Thr Thr Gly Thr Gly Cys 
    930                 935                 940                 


Gly Thr Thr Cys Ala Cys Gly Cys Ala Thr Ala Ala Ala Gly Cys Cys 
945                 950                 955                 960 


Gly Gly Thr Ala Thr Cys Cys Ala Thr Gly Cys Gly Ala Ala Ala Gly 
                965                 970                 975     


Cys Thr Ala Thr Cys Cys Thr Gly Gly Cys Ala Ala Ala Thr Cys Cys 
            980                 985                 990         


Gly Thr Cys Ala Ala Cys Thr Thr  Ala Cys Gly Ala Gly  Ala Thr Thr 
        995                 1000                 1005             


Cys Thr  Gly Cys Ala Gly Cys  Cys Ala Ala Gly Cys  Gly Ala Cys 
    1010                 1015                 1020             


Thr Thr  Cys Gly Gly Thr Cys  Thr Gly Ala Cys Thr  Cys Gly Gly 
    1025                 1030                 1035             


Thr Ala  Thr Ala Thr Thr Cys  Ala Thr Thr Thr Cys  Gly Cys Thr 
    1040                 1045                 1050             


Ala Ala  Cys Cys Gly Cys Cys  Thr Cys Ala Cys Gly  Gly Gly Cys 
    1055                 1060                 1065             


Thr Gly  Gly Ala Ala Cys Gly  Cys Thr Ala Thr Thr  Ala Ala Ala 
    1070                 1075                 1080             


Thr Cys  Thr Cys Gly Gly Gly  Thr Gly Gly Ala Thr  Cys Ala Gly 
    1085                 1090                 1095             


Cys Thr  Thr Ala Ala Cys Thr  Thr Gly Cys Ala Cys  Thr Thr Gly 
    1100                 1105                 1110             


Ala Cys  Gly Gly Ala Thr Gly  Cys Thr Cys Ala Ala  Thr Gly Cys 
    1115                 1120                 1125             


Ala Ala  Ala Gly Ala Gly Gly  Thr Cys Ala Cys Gly  Gly Cys Cys 
    1130                 1135                 1140             


Ala Ala  Ala Ala Thr Cys Ala  Ala Ala Ala Ala Gly  Ala Thr Gly 
    1145                 1150                 1155             


Gly Gly  Ala Gly Ala Thr Ala  Thr Cys Cys Gly Gly  Cys Cys Cys 
    1160                 1165                 1170             


Cys Thr  Thr Ala Ala Thr Ala  Thr Thr Gly Ala Thr  Gly Ala Cys 
    1175                 1180                 1185             


Gly Thr  Thr Gly Ala Thr Thr  Cys Ala Ala Thr Cys  Ala Thr Cys 
    1190                 1195                 1200             


Ala Ala  Gly Gly Ala Cys Thr  Thr Thr Cys Ala Cys  Gly Cys Cys 
    1205                 1210                 1215             


Gly Ala  Cys Ala Thr Thr Ala  Cys Thr Ala Cys Gly  Cys Cys Ala 
    1220                 1225                 1230             


Gly Cys  Ala Thr Thr Cys Cys  Cys Thr Cys Cys Cys  Gly Thr Ala 
    1235                 1240                 1245             


Gly Cys  Gly Ala Cys Gly Ala  Ala Thr Ala Ala Thr  Gly Ala Cys 
    1250                 1255                 1260             


Gly Ala  Gly Gly Ala Thr Gly  Thr Ala Gly Ala Ala  Cys Cys Ala 
    1265                 1270                 1275             


Gly Cys  Gly Ala Cys Gly Ala  Ala Gly Ala Ala Gly  Cys Ala Ala 
    1280                 1285                 1290             


Cys Gly  Thr Thr Thr Gly Gly  Ala Thr Cys Ala Ala  
    1295                 1300                 1305 


