                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       RAITER, ANNAT
 
<120>  TREATMENT OF DISEASES WITH MULTIMERIC PEPTIDES

<130>  81658

<150>  US 62/808,307
<151>  2019-02-21

<150>  US 62/808,319
<151>  2019-02-21

<150>  US 62/904,708
<151>  2019-09-24

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Placental Immunoregulatory Ferritin (PLIF) derived polypeptide 
       sequence

<400>  1

His His Leu Leu Arg Pro Arg Arg Arg Lys Arg Pro His Ser Ile Pro 
1               5                   10                  15      


Thr Pro Ile Leu Ile Phe Arg Ser Pro 
            20                  25  


<210>  2
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A monomer of the multimeric peptide

<400>  2

His Ser Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
1               5                   10              


<210>  3
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A monomer of the multimeric peptide

<400>  3

His Leu Leu Arg Pro Arg Arg Arg Lys Arg Pro His Ser Ile 
1               5                   10                  


<210>  4
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A monomer of the multimeric peptide

<400>  4

Arg Pro Arg Arg Arg Lys Arg Pro His Ser Ile Pro 
1               5                   10          


<210>  5
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A monomer of the multimeric peptide

<400>  5

Ser Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
1               5                   10          


<210>  6
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A monomer of the multimeric peptide

<400>  6

Pro His Ser Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
1               5                   10                  


<210>  7
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A monomer of the multimeric peptide

<400>  7

His His Leu Leu Arg Pro Arg Arg Arg Lys Arg 
1               5                   10      


<210>  8
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  8

Cys Gly His Ser Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
1               5                   10                  15  


<210>  9
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  9

Cys Gly His Leu Leu Arg Pro Arg Arg Arg Lys Arg Pro His Ser Ile 
1               5                   10                  15      


<210>  10
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  10

Cys Gly Arg Pro Arg Arg Arg Lys Arg Pro His Ser Ile Pro 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  11

Cys Gly Ser Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
1               5                   10                  


<210>  12
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  12

Cys Gly Pro His Ser Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
1               5                   10                  15      


<210>  13
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  13

Cys Gly His His Leu Leu Arg Pro Arg Arg Arg Lys Arg 
1               5                   10              


<210>  14
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Placental Immunoregulatory Ferritin (PLIF) derived polypeptide 
       sequence

<400>  14

Arg Pro His Ser Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
1               5                   10                  15  


<210>  15
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  15

His His Leu Leu Arg Pro 
1               5       


<210>  16
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  16

His Leu Leu Arg Pro Arg 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  17

Leu Leu Arg Pro Arg Arg 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  18

Leu Arg Pro Arg Arg Lys 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  19

Arg Pro Arg Arg Lys Arg 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  20

Pro Arg Arg Lys Arg Pro 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  21

Arg Arg Lys Arg Pro His 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  22

Arg Lys Arg Pro His Ser 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  23

Lys Arg Pro His Ser Ile 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  24

Arg Pro His Ser Ile Pro 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  25

Pro His Ser Ile Pro Thr 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  26

His Ser Ile Pro Thr Pro 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  27

Ser Ile Pro Thr Pro Ile 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  28

Ile Pro Thr Pro Ile Leu 
1               5       


<210>  29
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  29

Pro Thr Pro Ile Leu Ile 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  30

Thr Pro Ile Leu Ile Phe 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  31

Pro Ile Leu Ile Phe Arg 
1               5       


<210>  32
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  32

Ile Leu Ile Phe Arg Ser 
1               5       


<210>  33
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  33

Leu Ile Phe Arg Ser Pro 
1               5       


<210>  34
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  34

His His Leu Leu Arg Pro Arg 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  35

His Leu Leu Arg Pro Arg Arg 
1               5           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  36

Leu Leu Arg Pro Arg Arg Lys 
1               5           


<210>  37
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  37

Leu Arg Pro Arg Arg Lys Arg 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  38

Arg Pro Arg Arg Lys Arg Pro 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  39

Pro Arg Arg Lys Arg Pro His 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  40

Arg Arg Lys Arg Pro His Ser 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  41

Arg Lys Arg Pro His Ser Ile 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  42

Lys Arg Pro His Ser Ile Pro 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  43

Arg Pro His Ser Ile Pro Thr 
1               5           


<210>  44
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  44

Pro His Ser Ile Pro Thr Pro 
1               5           


<210>  45
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  45

His Ser Ile Pro Thr Pro Ile 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  46

Ser Ile Pro Thr Pro Ile Leu 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  47

Ile Pro Thr Pro Ile Leu Ile 
1               5           


<210>  48
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  48

Pro Thr Pro Ile Leu Ile Phe 
1               5           


<210>  49
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  49

Thr Pro Ile Leu Ile Phe Arg 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  50

Pro Ile Leu Ile Phe Arg Ser 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  51

Ile Leu Ile Phe Arg Ser Pro 
1               5           


<210>  52
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  52

His His Leu Leu Arg Pro Arg Arg 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  53

His Leu Leu Arg Pro Arg Arg Lys 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  54

Leu Leu Arg Pro Arg Arg Lys Arg 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  55

Leu Arg Pro Arg Arg Lys Arg Pro 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  56

Arg Pro Arg Arg Lys Arg Pro His 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  57

Pro Arg Arg Lys Arg Pro His Ser 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  58

Arg Arg Lys Arg Pro His Ser Ile 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  59

Arg Lys Arg Pro His Ser Ile Pro 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  60

Lys Arg Pro His Ser Ile Pro Thr 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  61

Arg Pro His Ser Ile Pro Thr Pro 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  62

Pro His Ser Ile Pro Thr Pro Ile 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  63

His Ser Ile Pro Thr Pro Ile Leu 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  64

Ser Ile Pro Thr Pro Ile Leu Ile 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  65

Ile Pro Thr Pro Ile Leu Ile Phe 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  66

Pro Thr Pro Ile Leu Ile Phe Arg 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  67

Thr Pro Ile Leu Ile Phe Arg Ser 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  68

Pro Ile Leu Ile Phe Arg Ser Pro 
1               5               


<210>  69
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  69

His His Leu Leu Arg Pro Arg Arg Lys 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  70

His Leu Leu Arg Pro Arg Arg Lys Arg 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  71

Leu Leu Arg Pro Arg Arg Lys Arg Pro 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  72

Leu Arg Pro Arg Arg Lys Arg Pro His 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  73

Arg Pro Arg Arg Lys Arg Pro His Ser 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  74

Pro Arg Arg Lys Arg Pro His Ser Ile 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  75

Arg Arg Lys Arg Pro His Ser Ile Pro 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  76

Arg Lys Arg Pro His Ser Ile Pro Thr 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  77

Lys Arg Pro His Ser Ile Pro Thr Pro 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  78

Arg Pro His Ser Ile Pro Thr Pro Ile 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  79

Pro His Ser Ile Pro Thr Pro Ile Leu 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  80

His Ser Ile Pro Thr Pro Ile Leu Ile 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  81

Ser Ile Pro Thr Pro Ile Leu Ile Phe 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  82

Ile Pro Thr Pro Ile Leu Ile Phe Arg 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  83

Pro Thr Pro Ile Leu Ile Phe Arg Ser 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  84

Thr Pro Ile Leu Ile Phe Arg Ser Pro 
1               5                   


<210>  85
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  85

His His Leu Leu Arg Pro Arg Arg Lys Arg 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  86

His Leu Leu Arg Pro Arg Arg Lys Arg Pro 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  87

Leu Leu Arg Pro Arg Arg Lys Arg Pro His 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  88

Leu Arg Pro Arg Arg Lys Arg Pro His Ser 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  89

Arg Pro Arg Arg Lys Arg Pro His Ser Ile 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  90

Pro Arg Arg Lys Arg Pro His Ser Ile Pro 
1               5                   10  


<210>  91
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  91

Arg Arg Lys Arg Pro His Ser Ile Pro Thr 
1               5                   10  


<210>  92
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  92

Arg Lys Arg Pro His Ser Ile Pro Thr Pro 
1               5                   10  


<210>  93
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  93

Lys Arg Pro His Ser Ile Pro Thr Pro Ile 
1               5                   10  


<210>  94
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  94

Arg Pro His Ser Ile Pro Thr Pro Ile Leu 
1               5                   10  


<210>  95
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  95

Pro His Ser Ile Pro Thr Pro Ile Leu Ile 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  96

His Ser Ile Pro Thr Pro Ile Leu Ile Phe 
1               5                   10  


<210>  97
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  97

Ser Ile Pro Thr Pro Ile Leu Ile Phe Arg 
1               5                   10  


<210>  98
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  98

Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser 
1               5                   10  


<210>  99
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary monomer of the multimeric peptide

<400>  99

Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
1               5                   10  


<210>  100
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Placental Immunoregulatory Ferritin (PLIF), C', derived peptide 
       C48

<400>  100

Phe Pro Ser Pro Ile Ser Pro Ser Pro Ser Cys Trp His His Tyr Thr 
1               5                   10                  15      


Thr Asn Arg Pro Gln Pro Gln His His Leu Leu Arg Pro Arg Arg Arg 
            20                  25                  30          


Lys Arg Pro His Ser Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
        35                  40                  45              


<210>  101
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  multimeric synthetic peptide

<400>  101

Cys Gly His His Leu Leu Arg Pro Arg Arg Arg Lys Arg Pro His Ser 
1               5                   10                  15      


Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
            20                  25          


<210>  102
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimeric synthetic peptide


<220>
<221>  DISULFID
<222>  (1)..(1)
<223>  polypeptide dimerizes through disulfide bond on cys number one

<400>  102

Cys Gly His His Leu Leu Arg Pro Arg Arg Arg Lys Arg Pro His Ser 
1               5                   10                  15      


Ile Pro Thr Pro Ile Leu Ile Phe Arg Ser Pro 
            20                  25          


<210>  103
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  104
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  105
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Glu Leu Trp Arg Gln Cys Thr His Trp Leu Ile Gln Cys Arg Val 
1               5                   10                  15      


Leu Pro Pro Ser His Arg Val Thr Trp Asp Gly Ala Gln Val Cys Glu 
            20                  25                  30          


Leu Ala Gln Ala Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu Asn 
        35                  40                  45              


Asn Leu Leu Pro His Ala Ile Asn Leu Arg Glu Val Asn Leu Arg Pro 
    50                  55                  60                  


Gln Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Ser 
65                  70                  75                  80  


Thr Cys Cys Glu Lys Phe Gly Leu Lys Arg Ser Glu Leu Phe Glu Ala 
                85                  90                  95      


Phe Asp Leu Phe Asp Val Gln Asp Phe Gly Lys Val Ile Tyr Thr Leu 
            100                 105                 110         


Ser Ala Leu Ser Trp Thr Pro Ile Ala Gln Asn Arg Gly Ile Met Pro 
        115                 120                 125             


Phe Pro Thr Glu Glu Glu Ser Val Gly Asp Glu Asp Ile Tyr Ser Gly 
    130                 135                 140                 


Leu Ser Asp Gln Ile Asp Asp Thr Val Glu Glu Asp Glu Asp Leu Tyr 
145                 150                 155                 160 


Asp Cys Val Glu Asn Glu Glu Ala Glu Gly Asp Glu Ile Tyr Glu Asp 
                165                 170                 175     


Leu Met Arg Ser Glu Pro Val Ser Met Pro Pro Lys Met Thr Glu Tyr 
            180                 185                 190         


Asp Lys Arg Cys Cys Cys Leu Arg Glu Ile Gln Gln Thr Glu Glu Lys 
        195                 200                 205             


Tyr Thr Asp Thr Leu Gly Ser Ile Gln Gln His Phe Leu Lys Pro Leu 
    210                 215                 220                 


Gln Arg Phe Leu Lys Pro Gln Asp Ile Glu Ile Ile Phe Ile Asn Ile 
225                 230                 235                 240 


Glu Asp Leu Leu Arg Val His Thr His Phe Leu Lys Glu Met Lys Glu 
                245                 250                 255     


Ala Leu Gly Thr Pro Gly Ala Ala Asn Leu Tyr Gln Val Phe Ile Lys 
            260                 265                 270         


Tyr Lys Glu Arg Phe Leu Val Tyr Gly Arg Tyr Cys Ser Gln Val Glu 
        275                 280                 285             


Ser Ala Ser Lys His Leu Asp Arg Val Ala Ala Ala Arg Glu Asp Val 
    290                 295                 300                 


Gln Met Lys Leu Glu Glu Cys Ser Gln Arg Ala Asn Asn Gly Arg Phe 
305                 310                 315                 320 


Thr Leu Arg Asp Leu Leu Met Val Pro Met Gln Arg Val Leu Lys Tyr 
                325                 330                 335     


His Leu Leu Leu Gln Glu Leu Val Lys His Thr Gln Glu Ala Met Glu 
            340                 345                 350         


Lys Glu Asn Leu Arg Leu Ala Leu Asp Ala Met Arg Asp Leu Ala Gln 
        355                 360                 365             


Cys Val Asn Glu Val Lys Arg Asp Asn Glu Thr Leu Arg Gln Ile Thr 
    370                 375                 380                 


Asn Phe Gln Leu Ser Ile Glu Asn Leu Asp Gln Ser Leu Ala His Tyr 
385                 390                 395                 400 


Gly Arg Pro Lys Ile Asp Gly Glu Leu Lys Ile Thr Ser Val Glu Arg 
                405                 410                 415     


Arg Ser Lys Met Asp Arg Tyr Ala Phe Leu Leu Asp Lys Ala Leu Leu 
            420                 425                 430         


Ile Cys Lys Arg Arg Gly Asp Ser Tyr Asp Leu Lys Asp Phe Val Asn 
        435                 440                 445             


Leu His Ser Phe Gln Val Arg Asp Asp Ser Ser Gly Asp Arg Asp Asn 
    450                 455                 460                 


Lys Lys Trp Ser His Met Phe Leu Leu Ile Glu Asp Gln Gly Ala Gln 
465                 470                 475                 480 


Gly Tyr Glu Leu Phe Phe Lys Thr Arg Glu Leu Lys Lys Lys Trp Met 
                485                 490                 495     


Glu Gln Phe Glu Met Ala Ile Ser Asn Ile Tyr Pro Glu Asn Ala Thr 
            500                 505                 510         


Ala Asn Gly His Asp Phe Gln Met Phe Ser Phe Glu Glu Thr Thr Ser 
        515                 520                 525             


Cys Lys Ala Cys Gln Met Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr 
    530                 535                 540                 


Arg Cys His Arg Cys Arg Ala Ser Ala His Lys Glu Cys Leu Gly Arg 
545                 550                 555                 560 


Val Pro Pro Cys Gly Arg His Gly Gln Asp Phe Pro Gly Thr Met Lys 
                565                 570                 575     


Lys Asp Lys Leu His Arg Arg Ala Gln Asp Lys Lys Arg Asn Glu Leu 
            580                 585                 590         


Gly Leu Pro Lys Met Glu Val Phe Gln Glu Tyr Tyr Gly Leu Pro Pro 
        595                 600                 605             


Pro Pro Gly Ala Ile Gly Pro Phe Leu Arg Leu Asn Pro Gly Asp Ile 
    610                 615                 620                 


Val Glu Leu Thr Lys Ala Glu Ala Glu Gln Asn Trp Trp Glu Gly Arg 
625                 630                 635                 640 


Asn Thr Ser Thr Asn Glu Ile Gly Trp Phe Pro Cys Asn Arg Val Lys 
                645                 650                 655     


Pro Tyr Val His Gly Pro Pro Gln Asp Leu Ser Val His Leu Trp Tyr 
            660                 665                 670         


Ala Gly Pro Met Glu Arg Ala Gly Ala Glu Ser Ile Leu Ala Asn Arg 
        675                 680                 685             


Ser Asp Gly Thr Phe Leu Val Arg Gln Arg Val Lys Asp Ala Ala Glu 
    690                 695                 700                 


Phe Ala Ile Ser Ile Lys Tyr Asn Val Glu Val Lys His Ile Lys Ile 
705                 710                 715                 720 


Met Thr Ala Glu Gly Leu Tyr Arg Ile Thr Glu Lys Lys Ala Phe Arg 
                725                 730                 735     


Gly Leu Thr Glu Leu Val Glu Phe Tyr Gln Gln Asn Ser Leu Lys Asp 
            740                 745                 750         


Cys Phe Lys Ser Leu Asp Thr Thr Leu Gln Phe Pro Phe Lys Glu Pro 
        755                 760                 765             


Glu Lys Arg Thr Ile Ser Arg Pro Ala Val Gly Ser Thr Lys Tyr Phe 
    770                 775                 780                 


Gly Thr Ala Lys Ala Arg Tyr Asp Phe Cys Ala Arg Asp Arg Ser Glu 
785                 790                 795                 800 


Leu Ser Leu Lys Glu Gly Asp Ile Ile Lys Ile Leu Asn Lys Lys Gly 
                805                 810                 815     


Gln Gln Gly Trp Trp Arg Gly Glu Ile Tyr Gly Arg Val Gly Trp Phe 
            820                 825                 830         


Pro Ala Asn Tyr Val Glu Glu Asp Tyr Ser Glu Tyr Cys 
        835                 840                 845 


<210>  106
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 


Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 


Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 
                165                 170                 175     


Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         


Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
        195                 200                 205             


Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
    210                 215                 220                 


Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
225                 230                 235                 240 


Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     


Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
            260                 265                 270         


Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
        275                 280                 285             


Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
    290                 295                 300                 


Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
305                 310                 315                 320 


Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
                325                 330                 335     


Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
            340                 345                 350         


Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
        355                 360                 365             


Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
    370                 375                 380                 


Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
385                 390                 395                 400 


Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
                405                 410                 415     


Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
            420                 425                 430         


Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
        435                 440                 445             


Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
    450                 455                 460                 


Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
465                 470                 475                 480 


Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
                485                 490                 495     


Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
            500                 505                 510         


Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
        515                 520                 525             


Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
    530                 535                 540                 


Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
545                 550                 555                 560 


Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
                565                 570                 575     


Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
            580                 585                 590         


Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
        595                 600                 605             


Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
    610                 615                 620                 


Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
625                 630                 635                 640 


Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
                645                 650                 655     


Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
            660                 665                 670         


Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
        675                 680                 685             


Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
    690                 695                 700                 


Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
705                 710                 715                 720 


Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
                725                 730                 735     


Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
            740                 745                 750         


Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
        755                 760                 765             


Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
    770                 775                 780                 


Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
785                 790                 795                 800 


Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
                805                 810                 815     


Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
            820                 825                 830         


Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
        835                 840                 845             


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
    850                 855                 860                 


Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
865                 870                 875                 880 


Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
                885                 890                 895     


Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
            900                 905                 910         


Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
        915                 920                 925             


Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
    930                 935                 940                 


Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
945                 950                 955                 960 


His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
                965                 970                 975     


Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
            980                 985                 990         


Met Ser Lys Glu Ser Glu His Asp  Ser Asp Glu Ser Ser  Asp Asp Asp 
        995                 1000                 1005             


Ser Asp  Ser Glu Glu Pro Ser  Lys Tyr Ile Asn Ala  Ser Phe Ile 
    1010                 1015                 1020             


Met Ser  Tyr Trp Lys Pro Glu  Val Met Ile Ala Ala  Gln Gly Pro 
    1025                 1030                 1035             


Leu Lys  Glu Thr Ile Gly Asp  Phe Trp Gln Met Ile  Phe Gln Arg 
    1040                 1045                 1050             


Lys Val  Lys Val Ile Val Met  Leu Thr Glu Leu Lys  His Gly Asp 
    1055                 1060                 1065             


Gln Glu  Ile Cys Ala Gln Tyr  Trp Gly Glu Gly Lys  Gln Thr Tyr 
    1070                 1075                 1080             


Gly Asp  Ile Glu Val Asp Leu  Lys Asp Thr Asp Lys  Ser Ser Thr 
    1085                 1090                 1095             


Tyr Thr  Leu Arg Val Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp 
    1100                 1105                 1110             


Ser Arg  Thr Val Tyr Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu 
    1115                 1120                 1125             


Gln Leu  Pro Ala Glu Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val 
    1130                 1135                 1140             


Val Lys  Gln Lys Leu Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys 
    1145                 1150                 1155             


His His  Lys Ser Thr Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser 
    1160                 1165                 1170             


Gln Gln  Thr Gly Ile Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser 
    1175                 1180                 1185             


Ala Glu  Thr Glu Glu Val Val  Asp Ile Phe Gln Val  Val Lys Ala 
    1190                 1195                 1200             


Leu Arg  Lys Ala Arg Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr 
    1205                 1210                 1215             


Gln Phe  Leu Tyr Asp Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn 
    1220                 1225                 1230             


Gly Gln  Val Lys Lys Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe 
    1235                 1240                 1245             


Asp Asn  Glu Val Asp Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn 
    1250                 1255                 1260             


Pro Leu  Gly Ala Pro Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala 
    1265                 1270                 1275             


Glu Gly  Ser Glu Pro Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser 
    1280                 1285                 1290             


Val Asn  Gly Pro Ala Ser Pro  Ala Leu Asn Gln Gly  Ser 
    1295                 1300                 1305     


