                         SEQUENCE LISTING

<110>  Oncolytics Biotech Inc.
 
<120>  T Cell Repertoire Dynamics And Oncolytic Viral Therapy

<130>  095178-1178546 (099WO1)

<150>  62/809,190
<151>  2019-02-22

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  1416
<212>  DNA
<213>  reovirus

<400>  1
gctattggtc ggatggatcc tcgcctacgt gaagaagtag tacggctgat aatcgcatta       60

acgagtgata atggagcatc actgtcaaaa gggcttgaat caagggtctc ggcgctcgag      120

aagacgtctc aaatacactc tgatactatc ctccggatca cccagggact cgatgatgca      180

aacaaacgaa tcatcgctct tgagcaaagt cgggatgact tggttgcatc agtcagtgat      240

gctcaacttg caatctccag attggaaagc tctatcggag ccctccaaac agttgtcaat      300

ggacttgatt cgagtgttac ccagttgggt gctcgagtgg gacaacttga gacaggactt      360

gcagagctac gcgttgatca cgacaatctc gttgcgagag tggatactgc agaacgtaac      420

attggatcat tgaccactga gctatcaact ctgacgttac gagtaacatc catacaagcg      480

gatttcgaat ctaggatatc cacgttagag cgcacggcgg tcactagcgc gggagctccc      540

ctctcaatcc gtaataaccg tatgaccatg ggattaaatg atggactcac gttgtcaggg      600

aataatctcg ccatccgatt gccaggaaat acgggtctga atattcaaaa tggtggactt      660

cagtttcgat ttaatactga tcaattccag atagttaata ataacttgac tctcaagacg      720

actgtgtttg attctatcaa ctcaaggata ggcgcaactg agcaaagtta cgtggcgtcg      780

gcagtgactc ccttgagatt aaacagtagc acgaaggtgc tggatatgct aatagacagt      840

tcaacacttg aaattaattc tagtggacag ctaactgtta gatcgacatc cccgaatttg      900

aggtatccga tagctgatgt tagcggcggt atcggaatga gtccaaatta taggtttagg      960

cagagcatgt ggataggaat tgtctcctat tctggtagtg ggctgaattg gagggtacag     1020

gtgaactccg acatttttat tgtagatgat tacatacata tatgtcttcc agcttttgac     1080

ggtttctcta tagctgacgg tggagatcta tcgttgaact ttgttaccgg attgttacca     1140

ccgttactta caggagacac tgagcccgct tttcataatg acgtggtcac atatggagca     1200

cagactgtag ctatagggtt gtcgtcgggt ggtgcgcctc agtatatgag taagaatctg     1260

tgggtggagc agtggcagga tggagtactt cggttacgtg ttgagggggg tggctcaatt     1320

acgcactcaa acagtaagtg gcctgccatg accgtttcgt acccgcgtag tttcacgtga     1380

ggatcagacc accccgcggc actggggcat ttcatc                               1416


<210>  2
<211>  1331
<212>  DNA
<213>  reovirus

<400>  2
gctattcgct ggtcagttat ggctcgcgct gcgttcctat tcaagactgt tgggtttggt       60

ggtctgcaaa atgtgccaat taacgacgaa ctatcttcac atctactccg agctggtaat      120

tcaccatggc agttaacaca gtttttagac tggataagcc ttgggagggg tttagctaca      180

tcggctctcg ttccgacggc tgggtcaaga tactatcaaa tgagttgcct tctaagtggc      240

actctccaga ttccgttccg tcctaaccac cgatggggag acattaggtt cttacgctta      300

gtgtggtcag ctcctactct cgatggatta gtcgtagctc caccacaagt tttggctcag      360

cccgctttgc aagcacaggc agatcgagtg tacgactgcg atgattatcc atttctagcg      420

cgtgatccaa gattcaaaca tcgggtgtat cagcaattga gtgctgtaac tctacttaac      480

ttgacaggtt ttggcccgat ttcctacgtt cgagtggatg aagatatgtg gagtggagat      540

gtgaaccagc ttctcatgaa ctatttcggg cacacgtttg cagagattgc atacacattg      600

tgtcaagcct cggctaatag gccttgggaa tatgacggta catatgctag gatgactcag      660

attgtgttat ccttgttctg gctatcgtat gtcggtgtaa ttcatcagca gaatacgtat      720

cggacattct attttcagtg taatcggcga ggtgacgccg ctgaggtgtg gattctttct      780

tgttcgttga accattccgc acaaattaga ccgggtaatc gtagcttatt cgttatgcca      840

actagcccag attggaacat ggacgtcaat ttgatcctga gttcaacgtt gacggggtgt      900

ttgtgttcgg gttcacagct gccactgatt gacaataatt cagtacctgc agtgtcgcgt      960

aacatccatg gctggactgg tagagctggt aaccaattgc atgggttcca ggtgagacga     1020

atggtgactg aattttgtga caggttgaga cgcgatggtg tcatgaccca agctcagcag     1080

aatcaagttg aagcgttggc agatcagact caacagttta agagggacaa gctcgaaacg     1140

tgggcgagag aagacgatca atataatcag gctcatccca actccacaat gttccgtacg     1200

aaaccattta cgaatgcgca atggggacga ggtaatacgg gggcgactag tgccgcgatt     1260

gcagccctta tctgatcgtc ttggagtgag ggggtccccc cacacacctc acgactgacc     1320

acacattcat c                                                          1331


<210>  3
<211>  1198
<212>  DNA
<213>  reovirus

<400>  3
gctaaagtca cgcctgtcgt cgtcactatg gcttcctcac tcagagctgc gatctccaag       60

atcaagaggg atgacgtcgg tcagcaagtt tgtcctaatt atgtcatgct gcggtcctct      120

gtcacaacaa aggtggtacg aaatgtggtt gagtatcaaa ttcgtacggg cggattcttt      180

tcgtgcttag ctatgctaag gccactccag tacgctaagc gtgagcgttt gcttggtcag      240

aggaatctgg aacgtatatc gactagggat atccttcaga ctcgtgattt acactcacta      300

tgtatgccaa ctcctgatgc gccaatgtct aatcatcaag catccaccat gagagagctg      360

atttgcagtt acttcaaggt cgatcatgcg gatgggttga aatatatacc catggatgag      420

agatactctc cgtcatcact tgccagattg tttaccatgg gcatggctgg gctgcacatt      480

accactgagc catcttataa gcgtgttccg attatgcact tagctgcgga cttggactgt      540

atgacgctgg ctctacctta catgattacg cttgatggtg atactgtggt tcctgtcgct      600

ccaacactgt cagcggaaca gcttctggac gacggactca aaggattagc atgcatggat      660

atctcctatg gatgtgaggt ggacgcgaat agccggccgg ctggtgatca gagtatggac      720

tcttcacgct gcatcaacga gttgtattgc gaggagacag cagaagccat ctgtgtgctt      780

aagacatgcc ttgtgttaaa ttgcatgcag tttaaacttg agatggatga cctagcacat      840

aacgctgctg agctggacaa gatacagatg atgataccct tcagtgagcg tgtttttagg      900

atggcctcgt cctttgcgac tattgatgcc cagtgtttta ggttttgcgt gatgatgaag      960

gataaaaatc tgaaaataga tatgcgtgaa acgacgagac tgtggactcg ttcagcatca     1020

gatgattctg tggccacgtc atctttaagt atttccctgg accggggtcg atgggtggcg     1080

gctgacgcca gtgatgctag actgctggtt tttccgattc gcgtgtaatg ggtgagtgag     1140

ctgatgtggt cgccaagaca tgtgccggtg tcttggtggt gggtgacgcc taatcatc       1198


<210>  4
<211>  1196
<212>  DNA
<213>  reovirus

<400>  4
gctatttttg cctcttccca gacgttgtcg caatggaggt gtgcttgccc aacggtcatc       60

aggtcgtgga cttaattaac aacgcttttg aaggtcgtgt atcaatctac agcgcgcaag      120

agggatggga caaaacaatc tcagcacagc cagatatgat ggtatgtggt ggcgccgtcg      180

tttgcatgca ttgtctaggt gttgttggat ctctacaacg caagctgaag catttgcctc      240

accatagatg taatcaacag atccgtcatc aggattacgt cgatgtacag ttcgcagacc      300

gtgttactgc tcactggaag cggggtatgc tgtccttcgt tgcgcagatg cacgagatga      360

tgaatgacgt gtcgccagat gacctggatc gtgtgcgtac tgagggaggt tcactagtgg      420

agctgaaccg gcttcaggtt gacccaaatt caatgtttag atcaatacac tcaagttgga      480

cagatccttt gcaggtggtg gacgaccttg acactaagct ggatcagtac tggacagcct      540

taaacctgat gatcgactca tccgacttga tacccaactt tatgatgaga gacccatcac      600

acgcgttcaa tggtgtgaaa ctgaagggag atgctcgtca aacccaattc tccaggactt      660

ttgattcgag atcgagtttg gaatggggtg tgatggttta tgattactct gagctggatc      720

atgatccatc gaagggccgt gcttacagaa aggaattggt gacgccagct cgagatttcg      780

gtcactttgg attatcccat tattctaggg cgactacccc aatccttgga aagatgccgg      840

ccgtattctc aggaatgttg actgggaact gtaaaatgta tccattcatt aaaggaacgg      900

ctaagctgaa gacagtgcgc aagctagtgg aggcagtcaa tcatgcttgg ggtgtcgaga      960

agattagata tgctcttggg ccaggtggca tgacgggatg gtacaatagg actatgcaac     1020

aggcccccat tgtgctaact cctgctgctc tcacaatgtt cccagatacc atcaagtttg     1080

gggatttgaa ttatccagtg atgattggcg atccgatgat tcttggctaa acacccccat     1140

cttcacagcg ccgggcttga ccaacctggt gtgacgtggg acaggcttca ttcatc         1196


<210>  5
<211>  2304
<212>  DNA
<213>  reovirus

<400>  5
gctattcgcg gtcatggctt acatcgcagt tcctgcggtg gtggattcac gttcgagtga       60

ggctattgga ctgctagaat cgtttggagt agacgctggg gctgacgcga atgacgtttc      120

atatcaagat catgactatg tgttggatca gttacagtac atgttagatg gatatgaggc      180

tggtgacgtt atcgatgcac tcgtccacaa gaattggtta catcactctg tctattgctt      240

gttgccaccc aaaagtcaac tattagagta ttggaaaagt aatccttcag cgataccgga      300

caacgttgat cgtcggcttc gtaaacgact aatgctaaag aaagatctca ggaaagatga      360

tgaatacaat cagctagcgc gtgctttcaa gatatcggat gtctacgcac ctctcatctc      420

atccacgacg tcaccgatga caatgataca gaacttgaat cgaggcgaga tcgtgtacac      480

cacgacggac agggtaatag gggctagaat cttgttatat gctcctagaa agtactatgc      540

gtcaactctg tcatttacta tgactaagtg catcattccg tttggtaaag aggtgggtcg      600

tgttcctcac tctcgattta atgttggcac atttccgtca attgctaccc cgaaatgttt      660

tgtcatgagt ggggttgata ttgagtccat cccaaatgaa tttatcaagt tgttttacca      720

gcgcgtcaag agtgttcacg ctaacatact aaatgacata tctcctcaga tcgtctctga      780

catgataaac agaaagcgtc tgcgcgttca tactccatca gatcgtcgag ccgcgcagtt      840

gatgcatttg ccttaccatg ttaaacgagg agcgtctcac gtcgacgttt acaaggtgga      900

tgttgtagac atgttgttcg aggtagtgga tgtggccgat gggttgcgca acgtatctag      960

gaaactaact atgcataccg ttcctgtatg tattcttgaa atgttgggta ttgagattgc     1020

ggactattgc attcgtcaag aggatggaat gctcacagat tggttcctac ttttaaccat     1080

gctatctgat ggcttgactg atagaaggac gcattgtcaa tacttgatta atccgtcaag     1140

tgtgcctcct gatgtgatac ttaacatctc aattactgga tttataaata gacatacaat     1200

cgatgtcatg cctgacatat atgacttcgt taaacccatt ggcgctgtgc tgcctaaggg     1260

atcatttaaa tcaacaatta tgagagttct tgattcaata tcaatattag gaatccaaat     1320

catgccgcgc gcgcatgtag ttgactcaga tgaggtgggc gagcaaatgg agcctacgtt     1380

tgagcaggcg gttatggaga tatacaaagg gattgctggc gttgactcgc tggatgatct     1440

catcaagtgg gtgttgaact cggatctcat tccgcatgat gacaggcttg gtcaattatt     1500

tcaagcgttt ttgcctctcg caaaggactt attagctcca atggccagaa agttttatga     1560

taactcaatg agtgagggta gattgctaac attctctcat gccgacagtg agttgctgaa     1620

cgcaaattat tttggtcatt tattgcgact aaaaatacca tatattacag aggttaatct     1680

gatgattcgc aagaatcgtg agggtggaga gctatttcag cttgtgttat cttatctata     1740

taaaatgtat gctactagcg cgcagcctaa atggtttgga tcattattgc gattgttaat     1800

atgtccctgg ttacatatgg agaaattaat aggagaagca gacccggcat ctacgtcggc     1860

tgaaattggg tggcatatcc ctcgtgaaca gctgatgcaa gatggatggt gtggatgtga     1920

agacggattc attccctatg ttagcatacg tgcgccaaga ctggttatag aggagttgat     1980

ggagaagaac tggggccaat atcatgccca agttattgtc actgatcagc ttgtcgtagg     2040

cgaaccgcgg agggtatctg ctaaggctgt gatcaagggt aaccacttac cagttaagtt     2100

agtttcacga tttgcatgtt tcacattgac ggcgaagtat gagatgaggc tttcgtgcgg     2160

ccatagcact ggacgtggag ctgcatacag tgcgagacta gctttccgat ctgacttggc     2220

gtgatccgtg acatgcgtag tgtgacacct gctcctaggt caatgggggt agggggcggg     2280

ctaagactac gtacgcgctt catc                                            2304


<210>  6
<211>  2204
<212>  DNA
<213>  reovirus

<400>  6
ggctaatctg ctgaccgtta ctctgcaaag atggggaacg cttcctctat cgttcagacg       60

atcaacgtca ctggagatgg caatgtattt aaaccatcag ctgaaacttc atctaccgct      120

gtaccatcgt taagcttatc acctggaatg ctgaatcccg gaggggtacc atggattgct      180

gttggagatg agacatctgt gacttcacca ggcgcattac gtcgaatgac gtcaaaggac      240

atcccggaca cggcaataat caacacagac aattcatcag gcgccgtgcc aagcgaatca      300

gccttggtgc cctacatcga tgagccgctg gtagtggtta cagagcatgc tattaccaac      360

ttcaccaaag ctgagatggc acttgaattc aatcgtgagt tccttgacaa gatgcgtgtg      420

ctgtcagtgt caccaaaata ttcggatctt ctgacctatg ttgactgcta cgtcggtgtg      480

tctgctcgtc aggctttaaa caattttcag aaacaagtgc ctgtgattac acctactagg      540

cagacgatgt atgtcgactc gatacaagcg gccttgaaag ctttagaaaa gtgggagatt      600

gatctgagag tggctcaaac gttgctgcct acgaacgttc cgattggaga agtctcttgt      660

ccaatgcagt cggtagtgaa actgctggat gatcagctgc cagatgacag cctgatacgg      720

aggtatccca aggaagccgc cgtcgctttg gctaaacgaa acgggggaat acaatggatg      780

gacgtatcag aaggcaccgt gatgaacgag gctgtcaacg ctgttgcagc tagtgcactg      840

gcaccttcag catcagcccc acccttagaa gagaagtcaa agttaaccga acaagcgatg      900

gatctcgtga ccgcggctga gcctgagata attgcctcac tcgcgccagt tcccgcaccc      960

gtgtttgcca taccacctaa accagcagat tataatgtgc gtactctgag gatcgacgag     1020

gccacttggc tgcgaatgat tccaaaatca atgaacacac cttttcaaat ccaggtgact     1080

gataacacag gaactaattg gcatctcaat ttgagggggg ggactcgtgt agtgaatctg     1140

gaccaaatcg ctccgatgcg gtttgtatta gatctagggg gaaagagtta taaagagacg     1200

agctgggatc caaacggcaa gaaggtcgga ttcatcgttt ttcaatcgaa gataccattc     1260

gaactttgga ctgctgcttc acagatcggt caagccacgg tggttaacta tgtccaacta     1320

tacgctgaag acagctcatt taccgcgcag tctatcattg ctactacctc tttggcttat     1380

aactatgagc ctgagcagtt gaataagact gaccctgaga tgaattatta tcttttggcg     1440

acctttatag actcagccgc tataacgcca acgaatatga cacagcctga tgtttgggat     1500

gccttgctga cgatgtcccc actatcagct ggcgaggtga cagtgaaggg tgcggtagtg     1560

agtgaagtag tccctgcaga cttgataggt agctacactc cagaatccct aaacgcctca     1620

cttccgaatg atgctgctag atgcatgatc gatagagctt cgaagatagc cgaagcaatc     1680

aagattgatg atgatgctgg accagatgaa tattccccaa actctgtacc aattcaaggt     1740

cagcttgcta tctcgcaact cgaaactgga tatggtgtgc gaatattcaa ccctaaaggg     1800

atcctttcta aaattgcatc tagggcaatg caggctttca ttggtgaccc gagcacaatc     1860

atcacgcagg cggcgccagt gttatcagac aagaataatt ggattgcatt ggcacaggga     1920

gtgaaaacta gtctgcgtac taaaagtcta tcagcgggag tgaagactgc agtgagtaag     1980

ctgagctcat ctgagtctat ccagaattgg actcaaggat tcttggataa agtgtcagcg     2040

cattttccag caccaaagcc cgattgtccg actagcggag atagtggtga atcgtctaat     2100

cgccgagtga agcgcgactc atacgcagga gtggtcaaac gtgggtacac acgttaggcc     2160

gctcgccctg gtgacgcggg gttaagggat gcaggcaaat catc                      2204


<210>  7
<211>  2241
<212>  DNA
<213>  revovirus

<400>  7
gctaaagtga ccgtggtcat ggcttcattc aagggattct ccgccaacac tgttccagtt       60

tctaaggcca agcgtgacat atcatctctt gccgctactc ctggacttcg ttcacaatcc      120

ttcactccgt ctgtggatat gtctcaatcg cgtgaattcc tcacaaaggc aattgagcaa      180

gggtccatgt ctatacctta tcagcatgtg aatgtaccga aagttgatcg taaagttgtt      240

agcctggtag tgcgaccttt ctcttcaggt gctttctcta tctctggagt gatttcgcca      300

gcccatgcct atctactaga gtgtctaccc cagcttgagc aggcgatggc ttttgttgct      360

tcacctgagt ctttccaggc ttccgacgtc gcgaagcgct ttgccataaa gccaggtatg      420

agcctccagg atgccatcac tgcctttatt aactttgtgt ccgcgatgct gaaaatgacg      480

gtgactcgtc aaaactttga cgttattgtg gctgagatcg agaggcttgc ttcaaccagc      540

gtgtccgtca ggactgaaga agcgaaggtt gctgatgagg agctaatgct attcgggtta      600

gatcatagag ggccacagca gctggatgtt tctgacgcta aagggataat gaaggctgct      660

gatattcaga caactcatga tgtccatttg gcaccaggcg ttggtaatat tgatcctgaa      720

atctataacg aggggcggtt catgttcatg cagcacaagc cacttgcggc ggatcaatcg      780

tatttcacct tggagactgc ggattatttc aagatttatc caacatacga tgaacatgat      840

ggcaggatgg ctgaccaaaa gcagtcggga ttgatactgt gtactaagga cgaggtattg      900

gctgagcaaa ctatatttaa actggacgcc cctgatgaca agactgttca tctgttggat      960

cgcgatgacg accacgttgt tgccagattt actaaggtat ttatagagga cgtggctccc     1020

gggcatcatg ctgctcaaag atcgggacaa cgctctgtgc ttgatgacct atatgcgaat     1080

acgcaagtga tttccattac ttctgctgct ttaaagtggg tggtcaagca cggcgtatct     1140

gatggaatcg tgaacaggaa gaatgtcaaa gtgtgtgttg gttttgaccc cctgtacacc     1200

ttgtctacac ataacggggt gtccttatgt gccctgctga tggacgaaaa actctctgtg     1260

ctgaacagtg cgtgtcgtat gacgttacgc tcactcatga agaccggacg cgacgttgat     1320

gcacacagag cttttcagcg agtcctctct caaggataca catcgctaat gtgctactat     1380

catccttcac ggaagttggc atatggtgag gtgctctttc tagaacgatc caatgacgtg     1440

acagatggga tcaagcttca gttggacgca tctagacagt gtcatgaatg tcctgtgttg     1500

cagcagaaag tggttgagtt agagaaacag attattatgc agaagtcaat ccagtcagac     1560

cctaccccag tggcgctgca accattgttg tctcagttgc gtgagttgtc tagtgaagtt     1620

actaggctac agatggagtt gagtcgagct cagtccctga atgctcagtt ggaggcggat     1680

gtcaagtcag ctcaatcatg tagcttggat atgtatctga gacaccacac ttgcattaat     1740

ggtcatgcta aagaagatga attgcttgac gctgtgcgtg tcgcgccgga tgtgaggaga     1800

gaaatcatgg aaaagaggag tgaagtgaga caaggttggt gcgaacgtat ttctaaggaa     1860

gcagctgcca aatgtcaaac tgttattgat gacctgactt tgatgaatgg aaagcaagca     1920

caagagataa cagaattacg tgattcggct gaaaaatatg agaaacagat tgcagagctg     1980

gtgagtacca tcacccaaaa ccagataacg tatcagcaag agctacaagc cttggtagcg     2040

aaaaatgtgg aattggacgc gttgaatcag cgtcaggcta agtctttgcg tattactccc     2100

tctcttctat cagccactcc tatcgattca gttgatgatg ttgctgactt aattgatttc     2160

tctgttccaa ctgatgagtt gtaaataatc cgtgatgcag tgttgcccta atcccttaag     2220

ccttcccgac ccccattcat c                                               2241


<210>  8
<211>  3854
<212>  DNA
<213>  reovirus

<400>  8
gctacacgtt ccacgacaat gtcatccatg atactgactc agtttggacc gttcattgag       60

agcatttcag gtatcactga tcaatcgaat gacgtgtttg aagatgcagc aaaagcattc      120

tctatgttta ctcgcagcga tgtctacaag gcgctggatg aaataccttt ctctgatgat      180

gcgatgcttc caatccctcc aactatatat acgaaaccat ctcacgattc atattattac      240

attgatgctc taaaccgtgt gcgtcgcaaa acatatcagg gccctgatga cgtgtacgta      300

cctaattgtt ctattgttga attgctggag ccacatgaga ctctgacatc ttatgggcgg      360

ttgtccgagg ccatcgagaa tcgtgccaag gatggggaca gccaagccag aatcgccaca      420

acgtatggta gaatcgctga atctcaagct cgacagatta aggctccatt ggagaagttt      480

gtgttggcac tattagtggc cgaagcaggg gggtctttat atgatccagt tttgcagaag      540

tatgatgaga ttccagatct atcgcataat tgccctttat ggtgttttag agagatctgt      600

cgtcacatat ctggtccatt accagatcgg gcaccttatc tttacttatc tgcaggggtt      660

ttctggttaa tgtcaccacg aatgacgtct gcaatccctc cgctactatc cgatcttgtt      720

aatttagcta ttttgcaaca aactgcgggt ttagatccat cattagtgaa attgggagta      780

cagatatgcc ttcatgcagc agctagctca agttatgcat ggtttatctt aaagactaag      840

tctatttttc ctcaaaacac gttgcacagt atgtatgaat ctctagaagg gggatactgt      900

cctaatcttg aatggttaga gcctagatca gactataagt tcatgtacat gggagtcatg      960

ccattgtccg ctaagtatgc taggtcggcg ccgtccaatg ataagaaagc gcgggaactt     1020

ggcgagaaat atggactgag ctcagtcgtc ggtgagcttc gtaaacggac aaagacgtat     1080

gttaaacatg actttgcttc agtgaggtac attcgtgacg ctatggcatg tactagcggt     1140

attttcttgg taagaacacc caccgaaacg gtattgcaag aatatacgca gagtccggag     1200

attaaggttc ccattcccca gaaagactgg acaggcccaa taggtgaaat cagaattcta     1260

aaagatacaa caagttccat cgcgcgttac ttatatagaa catggtactt ggcagcggcg     1320

agaatggcgg ctcaaccacg tacgtgggat ccattgtttc aagcgattat gagatctcaa     1380

tacgtgacag ctaggggtgg atctggcgca gcactccgcg aatctttgta tgcaatcaat     1440

gtgtcgttac ctgatttcaa gggcttacca gtgaaggcag caactaagat attccaggcg     1500

gcacaattag cgaacttgcc gttctcccac acatcagtgg ctatactagc tgacacttca     1560

atgggattgc gaaatcaggt gcagaggcgg ccacgatcca ttatgccatt aaatgtgccc     1620

cagcagcagg tttcggcgcc ccatacattg acagcggatt acattaacta ccacatgaat     1680

ctatcaacca cgtctggtag tgcggtcatt gagaaggtga ttcctttagg tgtatacgct     1740

tcgagccctc ctaaccagtc gatcaacatt gacatatctg cgtgtgacgc tagtattact     1800

tgggatttct ttctgtcagt gattatggcg gctatacacg aaggtgtcgc tagtagctcc     1860

attggaaaac catttatggg ggttcctgca tccattgtaa atgatgagtc tgtcgttgga     1920

gtgagagctg ctaggccgat atcgggaatg cagaacatga ttcagcatct atcgaaacta     1980

tataaacgtg gattttcata tagagtaaac gattcttttt ctccaggtaa cgattttact     2040

catatgacta ccactttccc gtcaggttca acagccacct ctactgagca tactgctaat     2100

aatagtacga tgatggaaac tttcctgaca gtatggggac ccgaacatac tgacgaccct     2160

gacgtcttac gtttaatgaa gtctttaact attcaaagga attacgtatg tcaaggtgat     2220

gatggattaa tgattatcga tgggactact gctggtaagg tgaacagtga aactattcag     2280

aagatgctag aattaatctc aaaatatggt gaggaattcg gatggaaata tgacatagcg     2340

tacgatggga ctgccgaata cttaaagcta tacttcatat ttggctgtcg aattccaaat     2400

cttagtcgcc atccaatcgt ggggaaagaa cgggcgaatt cttcagcaga ggagccatgg     2460

ccagcaattc tagatcagat tatgggtgtc ttctttaatg gtgttcatga tgggttacag     2520

tggcagcggt ggatacgtta ttcatgggct ctatgctgtg ctttctcacg tcaaagaaca     2580

atgattggtg agagcgtggg ttaccttcaa tatcctatgt ggtcttttgt ctactgggga     2640

ttaccactgg ttaaagcgtt tgggtcagac ccatggatat tttcttggta catgcctact     2700

ggagatctgg gaatgtatag ttggattagc ttgatacgcc ctctgatgac aagatggatg     2760

gtggctaatg gttacgtaac tgacagatgc tcacccgtat tcgggaacgc agattatcgc     2820

aggtgtttca atgaacttaa actatatcaa ggttattata tggcacaatt gcccaggaat     2880

cctaagaagt ctggacgagc ggcccctcgg gaggtaagag aacaattcac tcaggcatta     2940

tccgactatc tactgcaaaa tccagagctg aagtcacgtg tgctacgtgg tcgtagtgag     3000

tgggagaaat atggagcggg gataattcac aatcctccgt cattattcga tgtgccccat     3060

aaatggtatc agggtgcgca agaggcagca atcgctacga gagaagagct ggcagaaatg     3120

gatgagacat taatgcgcgc tcgaaggcac agatattcga gcttttcaaa gttattagag     3180

gcgtatctgc tcgtgaaatg gcgaatgtgc gaggcccgcg aaccgtcggt ggatttgcga     3240

ttaccattat gtgcgggtat tgacccatta aactcagatc cttttctcaa gatggtaagc     3300

gttggaccaa tgctccagag tacgagaaag tactttgctc agacactatt catggcaaag     3360

acggtgtcgg gtcttgacgt taacgcgatt gatagcgcgt tattacgact gcgaacatta     3420

ggtgctgata agaaagcatt aacggcgcag ttattaatgg tggggcttca ggagtcagaa     3480

gcggacgcat tggccgggaa gataatgcta caggatgtga atactgtgca attagccaga     3540

gtggttaact tagctgtgcc agatacttgg atgtcgttag actttgactc tatgttcaaa     3600

caccacgtca agctgcttcc caaagatgga cgtcatctaa atactgatat tcctcctcga     3660

atgggatggt tacgggccat tttacgattc ttaggtgccg gaatggtaat gactgcgact     3720

ggagttgctg tcgacatcta tctggaggat atacatggcg gtggtcggtc acttggacag     3780

agattcatga cttggatgcg acaggaagga cggtcagcgt gagtctacca tgggtcgtgg     3840

tgcgtcaact catc                                                       3854


<210>  9
<211>  3916
<212>  DNA
<213>  reovirus

<400>  9
gctaaatggc gcgatggcga acgtttgggg ggtgagactt gcagactcgt tatcttcacc       60

cactattgag acacgaacgc gtcagtatac cttacacgat ctttgctcag acctagatgc      120

taatccgggg agggaaccgt ggaaacctct gcgtaatcag cgtactaata atattgtggc      180

tgtgcaatta ttcagaccat tgcagggttt agttttagat acccagcttt atggatttcc      240

aggagcattt gatgactggg agcgattcat gagagagaag ctgcgtgtgc taaagtatga      300

agtattgcgc atctatccaa tcagcaacta tagcaatgaa catgtcaacg tcttcgtggc      360

caatgctttg gtgggcgctt tcctgtcgaa tcaagctttc tatgacctgc taccgttgtt      420

gataattaat gacactatga ttggtgatct acttggcacg ggggcatcgc tatcacagtt      480

ctttcaatct catggagatg tgctggaagt cgcagctggt cgtaagtatc tgcagatgga      540

aaactactcc aacgatgacg atgatcctcc attatttgcg aaagacctgt cagattatgc      600

taaagcattc tacagtgaca catatgaagt gttggacagg ttcttttgga cgcatgactc      660

ttcagcgggg gtcttagtgc attatgataa gccaacgaat ggtcatcact atctgctggg      720

tactttgact cagatggtca gtgcacctcc ttatattatt aacgctactg acgcaatgtt      780

gcttgaatcc tgtctagaac agttctcagc taatgtgcgt gcgagacctg cgcaacccgt      840

tacacgctta gaccaatgct atcatttaag atggggagca caatatgtag gagaagattc      900

actgacatat cggttggggg tgttatcctt gctggctacc aatggatatc aattagctag      960

accgattcca agacagttga cgaatcgatg gttgtcgagc tttgtgagtc aaattatgtc     1020

tgacggcgtc aacgagactc cactgtggcc ccaagaaagg tatgtgcaga tcgcttatga     1080

ttcaccatcc gttgttgatg gggctacgca atatggctat gtcaggaaga atcaactcag     1140

actcggcatg agaatatcgg cgctgcaatc gctgagtgat acgccctcgc cggtacagtg     1200

gcttccacaa tacaccatcg accaggcagc gatggacgaa ggcgatctga tggttagtcg     1260

gcttacgcaa ctcccgttac gtcctgatta tggtaatatc tgggtcggcg atgcgctatc     1320

ctattatgtg gactacaatc ggagtcatcg agtcgtgctt tcatcggaac ttcctcagct     1380

tccggacaca tattttgatg gcgatgaaca gtatgggcgc agcctgttct cactagctcg     1440

taagattggt gaccgctcgt tagtgaaaga tacggctgtc ttgaagcacg cttaccaagc     1500

catcgatcca aatactggta aggagtatct gagatctcgg caatctgtcg catattttgg     1560

tgcatcagcg ggtcattctg gtgccgacca gccgttagtc atagagccct ggattcaagg     1620

gaaaatcagt ggtgtgccgc caccctcctc agtgcgacag ttcggctatg atgttgcccg     1680

tggcgcgatc gtcgatctgg cgagaccatt tccttctgga gattatcaat ttgtctattc     1740

ggatgttgac caggtggtcg atggccatga cgatctgagt atatcatctg gactggtgga     1800

gagccttttg tcttcatgca tgcacgccac agcacccggg ggctcatttg ttgttaagat     1860

aaattttccg actagacccg tatggcacta catcgaacag aagatcttgc ccaatattac     1920

gtcatacatg ttgatcaagc ctttcgtcac caacaacgtc gaattgttct tcgtcgcttt     1980

cggtgtgcat caacactcat cacttacttg gacatctgga gtgtacttct tcttggtgga     2040

ccatttttat cgttatgaga ctttatctac gatctcacga caattgccgt cttttgggta     2100

tgttgatgat gggtcttccg tgactggtat cgagacaatt agtattgaga accctggctt     2160

ctcgaatatg acccaggccg ctcgcattgg tatctcagga ttgtgtgcta atgtaggtaa     2220

cgcgcgtaag tccattgcca tttacgaatc tcatggggcc agagtattaa ctatcacatc     2280

aaggagatct ccggcatcag ctagaagaaa gtctaggttg cgatatttgc cattaataga     2340

ccctaggtcg ttagaggtac aggcgcgcac tattctgcca gctgatccag tgttatttga     2400

aaacgtgagc ggagcgtcac cccatgtttg tctgacaatg atgtacaact tcgaagtgtc     2460

gtcagcggta tatgatggag acgttgtgct agatcttggg acgggaccag aggctaaaat     2520

ccttgaactg atacccgcaa cctctccagt cacatgcgtg gacatacggc ctacagcgca     2580

gcctagtgga tgttggaacg ttcgtaccac gttccttgag ttagattatt tgagcgatgg     2640

atggatcact ggggtgcgtg gggacatagt tacttgtatg ttatctttgg gggccgctgc     2700

cgctggaaaa tcaatgactt ttgacgctgc gtttcagcaa ttaatcaaag tattatccaa     2760

gagtacggct aatgttgtgc tggtgcaggt taactgccct acagacgtgg tgaggagcat     2820

taagggctac ctagagatag attcgactaa caagaggtat aggttcccca aatttggtcg     2880

agacgagccg tactctgaca tggatgcgct ggagaaaata tgtcgtaccg cctggccaaa     2940

ctgctcaatt acctgggttc cattgtcata cgacttgcgg tggactagac tggcattatt     3000

agagtccacg acattgagta gcgcgtcgat tagaattgct gagctgatgt ataaatacat     3060

gcctattatg aggattgata ttcatggact acccatggaa aagcgaggta acttcatagt     3120

ggggcagaac tgctcattag taatccctgg ttttaatgcg caggatgtct ttaactgtta     3180

tttcaattcc gccctcgctt tctcgactga agatgtcaat gctgcgatga ttccccaagt     3240

gtctgcgcag tttgatgcga ctaagggtga gtggacgttg gatatggtct tctccgacgc     3300

aggaatctat accatgcagg ctctagtggg atctaatgct aatccagtct ctttgggttc     3360

ctttgtagtt gattctccag atgtagatat aactgacgct tggccagctc agttagactt     3420

tacgatcgcg ggaactgatg tcgatataac agttaatcct tattaccgtc tgatgacctt     3480

tgtaaggatc gatggacagt ggcagattgc caatccagac aaatttcaat tcttttcgtc     3540

ggcgtctggg acgttagtga tgaacgtcaa attagatatc gcagataaat atctactata     3600

ctatatacga gatgtccagt ctcgagatgt tggcttttac attcagcatc cacttcaact     3660

tttgaatacg atcacattgc caaccaacga ggaccttttt ctgagcgcac ctgacatgcg     3720

agagtgggca gttaaggaaa gcggtaacac gatatgtata ctcaatagtc aagggtttgt     3780

gctacctcaa gattgggatg tgttaacaga taccataagt tggtccccat cgatacccac     3840

atacattgtg ccaccgggtg attatacctt gactcctctg taactcactg tccctcgtga     3900

gcgcgcctaa ttcatc                                                     3916


<210>  10
<211>  3901
<212>  DNA
<213>  reovirus

<400>  10
gctaatcgtc aggatgaagc ggattccaag gaagacaaag ggcaaatcca gcggaaaggg       60

caatgactca acagagagag cggacgatgg ctcgagccaa ttaagagaca agcaaaacaa      120

taaggctggc cccgccacta cggagcctgg cacatccaac cgagagcaat acaaagctcg      180

accaggtatt gcatctgtgc agagggccac tgaaagtgca gaaatgccca tgaagaataa      240

tgacgaaggg acgccagata agaaaggaaa tactaagggc gacctagtta atgagcatag      300

tgaggctaaa gacgaggcgg atgaagcgac gaagaagcag gcaaaggata cagacaaaag      360

taaagcgcaa gtcacatatt cagacactgg tatcaataat gctaatgaac tgtcaagatc      420

tgggaatgtg gataatgagg gtggaagtaa tcagaagccg atgtctacca gaatagctga      480

ggcaacgtct gctatagtgt cgaaacatcc tgcgcgtgtt gggctgccac ctaccgctag      540

cagtggtcat gggtatcagt gccatgtctg ttctgcagtc ctgtttagtc ctttagacct      600

agatgcccac gtcgcctcac atggtttgca tggtaacatg acattaacat cgagtgatat      660

ccagcgacat ataactgagt tcatcagctc atggcaaaat catcctattg ttcaagtttc      720

ggctgatgtc gaaaataaga aaactgctca attgcttcac gctgacactc ctcgactcgt      780

cacttgggat gctggtttgt gtacttcatt caaaatcgtc ccgattgtgc cagctcaggt      840

gccgcaggat gtactggcct atacgttttt cacctcttca tacgctatcc aatcaccgtt      900

tccagaggcg gcagtgtcta ggattgtggt gcatacgaga tgggcatcta atgttgactt      960

tgaccgagac tcgtctgtca tcatggcgcc acctacagaa aacaatatcc atttgtttaa     1020

acagttacta aatactgaaa ccctgtctgt aaggggggct aatccgctaa tgttcagggc     1080

gaatgtgttg catatgttgc tagagttcgt attagataac ttgtatctga acagacatac     1140

gggattctct caagaccaca cgccatttac tgagggtgct aatttgcgtt cacttcctgg     1200

ccccgatgct gagaaatggt actcgattat gtatccaacg cgcatgggaa cgccgaatgt     1260

atccaaaata tgtaatttcg tcgcctcttg tgtgcgaaat cgggttggac ggtttgatcg     1320

agcacagatg atgaacggag ctatgtcaga gtgggtggat gtcttcgaga cttcagacgc     1380

gctaaccgtc tccattcgag gtcgatggat ggctagacta gctcgcatga acataaatcc     1440

aacagagatc gaatgggcat tgactgaatg tgcacaagga tatgtgactg tcacaagtcc     1500

ttacgctcct agcgtaaata gattgatgcc ctatcgtatc tccaacgctg agcggcaaat     1560

atcacagata atcaggatca tgaacattgg caataacgcg acggtgatac aacctgttct     1620

gcaagatatt tcggtactcc ttcaacgcat atcaccactc caaatagatc caactattat     1680

ttccaacact atgtcaacag tctcggagtc tactactcag accctcagcc ccgcgtcctc     1740

aattttgggt aaactacgac caagcaactc agatttttct agttttagag tcgcgttggc     1800

tggatggctt tataatgggg ttgtgacgac ggtgattgat gatagttcat atccaaaaga     1860

cggcggcagc gtgacctcac ttgaaaatct gtgggatttc ttcatccttg cgcttgctct     1920

accactgaca actgacccct gtgcacctgt gaaagcattc atgaccctag ccaacatgat     1980

ggttggtttc gagacaatcc ctatggataa tcagatctat actcaatcga gacgcgcgag     2040

tgctttctca acgcctcaca cgtggccacg atgctttatg aacatccagt taatttctcc     2100

aatcgacgct cccatcttgc gacagtgggc tgaaattatt catagatact ggcctaaccc     2160

ttcacagatt cgttatggtg caccgaacgt tttcggctcg gcaaatttgt tcactccacc     2220

tgaggtgctg ttattgccaa tcgatcatca accagctaat gtaacaacgc caacgctgga     2280

cttcaccaat gagttaacta attggcgcgc tcgtgtctgt gagcttatga agaatctcgt     2340

tgataaccaa agatatcaac ctggatggac acaaagtcta gtctcgtcaa tgcgcggaac     2400

gctagacaaa ttgaagttga ttaaatcgat gacaccaatg tatctgcaac agctggctcc     2460

ggtagagtta gcagtgatag ctcccatgtt gccttttcca cctttccagg tgccatacgt     2520

ccgtctcgat cgtgacagag ttccaacaat ggttggagta acacgacatt cacgagatac     2580

tattactcag ccggcgctat cgctgtcgac aaccaatact actgttggcg tgccactagc     2640

tctagacgcg agggctatca ccgttgcgct gttgtcaggg aaatatccgc cggatttggt     2700

gacaaatgta tggtacgctg atgccattta cccaatgtat gcagacacgg aggtgttctc     2760

taatcttcag agagacatga ttacctgcga ggccgtgcag acattagtga ctctggtggc     2820

gcaaatatca gagacccagt atcctgtaga taggtatctt gattggatcc catcactgag     2880

agcatcggcg gcgacggcgg cgacatttgc tgagtgggtt aatacttcaa tgaagacggc     2940

gtttgatttg tctgatatgc tgttagagcc tctcctaagc ggtgatccga ggatgactca     3000

actagcgatt cagtatcagc agtacaatgg cagaacgttt aatatcatac ctgaaatgcc     3060

aggttcagta attgctgact gcgttcaatt aacagcagaa gtctttaatc acgaatataa     3120

cctgtttggg attgcgcggg gtgatatcat cattggccgt gttcagtcga cacatttgtg     3180

gtcaccgctg gctcctccac ctgacctggt gtttgatcgt gatacccctg gtgttcacat     3240

cttcggacga gattgccgta tatcgtttgg aatgaatggc gccgcgccaa tgattagaga     3300

tgagactgga ctgatggtgc cttttgaagg aaattggatt ttcccactgg cgctttggca     3360

aatgaataca cgatatttta atcaacagtt cgacgcgtgg attaagacag gagagttgcg     3420

aatccgcatt gagatgggcg cgtatccata tatgttgcat tactatgatc cacgtcagta     3480

cgctaatgca tggaatttaa catccgcctg gcttgaagaa attacgccga cgagcatccc     3540

atccgtgcct ttcatggtgc ccatttcaag tgatcatgac atttcctctg ccccagctgt     3600

ccaatatatc atttcaactg aatataatga tcggtctctg ttctgcacta actcatcatc     3660

tccccaaacc atcgctggac cagacaaaca cattccagtt gagagatata acattctgac     3720

caaccccgac gctccaccca cgcagataca actgcctgaa gtcgttgact tgtacaacgt     3780

cgtcacacgc tatgcgtatg agactccgcc tattaccgct gttgttatgg gtgttccttg     3840

atcctcatcc tcccaacagg tgctagagca ttgcgctcaa tgctagttgg gccgattcat     3900

c                                                                     3901


<210>  11
<211>  455
<212>  PRT
<213>  reovirus

<400>  11

Met Asp Pro Arg Leu Arg Glu Glu Val Val Arg Leu Ile Ile Ala Leu 
1               5                   10                  15      


Thr Ser Asp Asn Gly Ala Ser Leu Ser Lys Gly Leu Glu Ser Arg Val 
            20                  25                  30          


Ser Ala Leu Glu Lys Thr Ser Gln Ile His Ser Asp Thr Ile Leu Arg 
        35                  40                  45              


Ile Thr Gln Gly Leu Asp Asp Ala Asn Lys Arg Ile Ile Ala Leu Glu 
    50                  55                  60                  


Gln Ser Arg Asp Asp Leu Val Ala Ser Val Ser Asp Ala Gln Leu Ala 
65                  70                  75                  80  


Ile Ser Arg Leu Glu Ser Ser Ile Gly Ala Leu Gln Thr Val Val Asn 
                85                  90                  95      


Gly Leu Asp Ser Ser Val Thr Gln Leu Gly Ala Arg Val Gly Gln Leu 
            100                 105                 110         


Glu Thr Gly Leu Ala Glu Leu Arg Val Asp His Asp Asn Leu Val Ala 
        115                 120                 125             


Arg Val Asp Thr Ala Glu Arg Asn Ile Gly Ser Leu Thr Thr Glu Leu 
    130                 135                 140                 


Ser Thr Leu Thr Leu Arg Val Thr Ser Ile Gln Ala Asp Phe Glu Ser 
145                 150                 155                 160 


Arg Ile Ser Thr Leu Glu Arg Thr Ala Val Thr Ser Ala Gly Ala Pro 
                165                 170                 175     


Leu Ser Ile Arg Asn Asn Arg Met Thr Met Gly Leu Asn Asp Gly Leu 
            180                 185                 190         


Thr Leu Ser Gly Asn Asn Leu Ala Ile Arg Leu Pro Gly Asn Thr Gly 
        195                 200                 205             


Leu Asn Ile Gln Asn Gly Gly Leu Gln Phe Arg Phe Asn Thr Asp Gln 
    210                 215                 220                 


Phe Gln Ile Val Asn Asn Asn Leu Thr Leu Lys Thr Thr Val Phe Asp 
225                 230                 235                 240 


Ser Ile Asn Ser Arg Ile Gly Ala Thr Glu Gln Ser Tyr Val Ala Ser 
                245                 250                 255     


Ala Val Thr Pro Leu Arg Leu Asn Ser Ser Thr Lys Val Leu Asp Met 
            260                 265                 270         


Leu Ile Asp Ser Ser Thr Leu Glu Ile Asn Ser Ser Gly Gln Leu Thr 
        275                 280                 285             


Val Arg Ser Thr Ser Pro Asn Leu Arg Tyr Pro Ile Ala Asp Val Ser 
    290                 295                 300                 


Gly Gly Ile Gly Met Ser Pro Asn Tyr Arg Phe Arg Gln Ser Met Trp 
305                 310                 315                 320 


Ile Gly Ile Val Ser Tyr Ser Gly Ser Gly Leu Asn Trp Arg Val Gln 
                325                 330                 335     


Val Asn Ser Asp Ile Phe Ile Val Asp Asp Tyr Ile His Ile Cys Leu 
            340                 345                 350         


Pro Ala Phe Asp Gly Phe Ser Ile Ala Asp Gly Gly Asp Leu Ser Leu 
        355                 360                 365             


Asn Phe Val Thr Gly Leu Leu Pro Pro Leu Leu Thr Gly Asp Thr Glu 
    370                 375                 380                 


Pro Ala Phe His Asn Asp Val Val Thr Tyr Gly Ala Gln Thr Val Ala 
385                 390                 395                 400 


Ile Gly Leu Ser Ser Gly Gly Ala Pro Gln Tyr Met Ser Lys Asn Leu 
                405                 410                 415     


Trp Val Glu Gln Trp Gln Asp Gly Val Leu Arg Leu Arg Val Glu Gly 
            420                 425                 430         


Gly Gly Ser Ile Thr His Ser Asn Ser Lys Trp Pro Ala Met Thr Val 
        435                 440                 445             


Ser Tyr Pro Arg Ser Phe Thr 
    450                 455 


<210>  12
<211>  418
<212>  PRT
<213>  reovirus

<400>  12

Met Ala Arg Ala Ala Phe Leu Phe Lys Thr Val Gly Phe Gly Gly Leu 
1               5                   10                  15      


Gln Asn Val Pro Ile Asn Asp Glu Leu Ser Ser His Leu Leu Arg Ala 
            20                  25                  30          


Gly Asn Ser Pro Trp Gln Leu Thr Gln Phe Leu Asp Trp Ile Ser Leu 
        35                  40                  45              


Gly Arg Gly Leu Ala Thr Ser Ala Leu Val Pro Thr Ala Gly Ser Arg 
    50                  55                  60                  


Tyr Tyr Gln Met Ser Cys Leu Leu Ser Gly Thr Leu Gln Ile Pro Phe 
65                  70                  75                  80  


Arg Pro Asn His Arg Trp Gly Asp Ile Arg Phe Leu Arg Leu Val Trp 
                85                  90                  95      


Ser Ala Pro Thr Leu Asp Gly Leu Val Val Ala Pro Pro Gln Val Leu 
            100                 105                 110         


Ala Gln Pro Ala Leu Gln Ala Gln Ala Asp Arg Val Tyr Asp Cys Asp 
        115                 120                 125             


Asp Tyr Pro Phe Leu Ala Arg Asp Pro Arg Phe Lys His Arg Val Tyr 
    130                 135                 140                 


Gln Gln Leu Ser Ala Val Thr Leu Leu Asn Leu Thr Gly Phe Gly Pro 
145                 150                 155                 160 


Ile Ser Tyr Val Arg Val Asp Glu Asp Met Trp Ser Gly Asp Val Asn 
                165                 170                 175     


Gln Leu Leu Met Asn Tyr Phe Gly His Thr Phe Ala Glu Ile Ala Tyr 
            180                 185                 190         


Thr Leu Cys Gln Ala Ser Ala Asn Arg Pro Trp Glu Tyr Asp Gly Thr 
        195                 200                 205             


Tyr Ala Arg Met Thr Gln Ile Val Leu Ser Leu Phe Trp Leu Ser Tyr 
    210                 215                 220                 


Val Gly Val Ile His Gln Gln Asn Thr Tyr Arg Thr Phe Tyr Phe Gln 
225                 230                 235                 240 


Cys Asn Arg Arg Gly Asp Ala Ala Glu Val Trp Ile Leu Ser Cys Ser 
                245                 250                 255     


Leu Asn His Ser Ala Gln Ile Arg Pro Gly Asn Arg Ser Leu Phe Val 
            260                 265                 270         


Met Pro Thr Ser Pro Asp Trp Asn Met Asp Val Asn Leu Ile Leu Ser 
        275                 280                 285             


Ser Thr Leu Thr Gly Cys Leu Cys Ser Gly Ser Gln Leu Pro Leu Ile 
    290                 295                 300                 


Asp Asn Asn Ser Val Pro Ala Val Ser Arg Asn Ile His Gly Trp Thr 
305                 310                 315                 320 


Gly Arg Ala Gly Asn Gln Leu His Gly Phe Gln Val Arg Arg Met Val 
                325                 330                 335     


Thr Glu Phe Cys Asp Arg Leu Arg Arg Asp Gly Val Met Thr Gln Ala 
            340                 345                 350         


Gln Gln Asn Gln Val Glu Ala Leu Ala Asp Gln Thr Gln Gln Phe Lys 
        355                 360                 365             


Arg Asp Lys Leu Glu Thr Trp Ala Arg Glu Asp Asp Gln Tyr Asn Gln 
    370                 375                 380                 


Ala His Pro Asn Ser Thr Met Phe Arg Thr Lys Pro Phe Thr Asn Ala 
385                 390                 395                 400 


Gln Trp Gly Arg Gly Asn Thr Gly Ala Thr Ser Ala Ala Ile Ala Ala 
                405                 410                 415     


Leu Ile 
        


<210>  13
<211>  254
<212>  PRT
<213>  reovirus

<400>  13

Met Ala Ser Ser Leu Arg Ala Ala Ile Ser Lys Ile Lys Arg Asp Asp 
1               5                   10                  15      


Val Gly Gln Gln Val Cys Pro Asn Tyr Val Met Leu Arg Ser Ser Val 
            20                  25                  30          


Thr Thr Lys Val Val Arg Asn Val Val Glu Tyr Gln Ile Arg Thr Gly 
        35                  40                  45              


Gly Phe Phe Ser Cys Leu Ala Met Leu Arg Pro Leu Gln Tyr Ala Lys 
    50                  55                  60                  


Arg Glu Arg Leu Leu Gly Gln Arg Asn Leu Glu Arg Ile Ser Thr Arg 
65                  70                  75                  80  


Asp Ile Leu Gln Thr Arg Asp Leu His Ser Leu Cys Met Pro Thr Pro 
                85                  90                  95      


Asp Ala Pro Met Ser Asn His Gln Ala Ser Thr Met Arg Glu Leu Ile 
            100                 105                 110         


Cys Ser Tyr Phe Lys Val Asp His Ala Asp Gly Leu Lys Tyr Ile Pro 
        115                 120                 125             


Met Asp Glu Arg Tyr Ser Pro Ser Ser Leu Ala Arg Leu Phe Thr Met 
    130                 135                 140                 


Gly Met Ala Gly Leu His Ile Thr Thr Glu Pro Ser Tyr Lys Arg Val 
145                 150                 155                 160 


Pro Ile Met His Leu Ala Ala Asp Leu Asp Cys Met Thr Leu Ala Leu 
                165                 170                 175     


Pro Tyr Met Ile Thr Leu Asp Gly Asp Thr Val Val Pro Val Ala Pro 
            180                 185                 190         


Thr Leu Ser Ala Glu Gln Leu Leu Asp Asp Gly Leu Lys Gly Leu Ala 
        195                 200                 205             


Cys Met Asp Met Asp Val Arg Trp Thr Arg Ile Ala Gly Arg Leu Val 
    210                 215                 220                 


Ile Arg Val Trp Thr Leu His Ala Ala Ser Thr Ser Cys Ile Ala Arg 
225                 230                 235                 240 


Arg Gln Gln Lys Pro Ser Val Cys Leu Arg His Ala Leu Cys 
                245                 250                 


<210>  14
<211>  366
<212>  PRT
<213>  reovirus

<400>  14

Met Ala Ser Ser Leu Arg Ala Ala Ile Ser Lys Ile Lys Arg Asp Asp 
1               5                   10                  15      


Val Gly Gln Gln Val Cys Pro Asn Tyr Val Met Leu Arg Ser Ser Val 
            20                  25                  30          


Thr Thr Lys Val Val Arg Asn Val Val Glu Tyr Gln Ile Arg Thr Gly 
        35                  40                  45              


Gly Phe Phe Ser Cys Leu Ala Met Leu Arg Pro Leu Gln Tyr Ala Lys 
    50                  55                  60                  


Arg Glu Arg Leu Leu Gly Gln Arg Asn Leu Glu Arg Ile Ser Thr Arg 
65                  70                  75                  80  


Asp Ile Leu Gln Thr Arg Asp Leu His Ser Leu Cys Met Pro Thr Pro 
                85                  90                  95      


Asp Ala Pro Met Ser Asn His Gln Ala Ser Thr Met Arg Glu Leu Ile 
            100                 105                 110         


Cys Ser Tyr Phe Lys Val Asp His Ala Asp Gly Leu Lys Tyr Ile Pro 
        115                 120                 125             


Met Asp Glu Arg Tyr Ser Pro Ser Ser Leu Ala Arg Leu Phe Thr Met 
    130                 135                 140                 


Gly Met Ala Gly Leu His Ile Thr Thr Glu Pro Ser Tyr Lys Arg Val 
145                 150                 155                 160 


Pro Ile Met His Leu Ala Ala Asp Leu Asp Cys Met Thr Leu Ala Leu 
                165                 170                 175     


Pro Tyr Met Ile Thr Leu Asp Gly Asp Thr Val Val Pro Val Ala Pro 
            180                 185                 190         


Thr Leu Ser Ala Glu Gln Leu Leu Asp Asp Gly Leu Lys Gly Leu Ala 
        195                 200                 205             


Cys Met Asp Ile Ser Tyr Gly Cys Glu Val Asp Ala Asn Ser Arg Pro 
    210                 215                 220                 


Ala Gly Asp Gln Ser Met Asp Ser Ser Arg Cys Ile Asn Glu Leu Tyr 
225                 230                 235                 240 


Cys Glu Glu Thr Ala Glu Ala Ile Cys Val Leu Lys Thr Cys Leu Val 
                245                 250                 255     


Leu Asn Cys Met Gln Phe Lys Leu Glu Met Asp Asp Leu Ala His Asn 
            260                 265                 270         


Ala Ala Glu Leu Asp Lys Ile Gln Met Met Ile Pro Phe Ser Glu Arg 
        275                 280                 285             


Val Phe Arg Met Ala Ser Ser Phe Ala Thr Ile Asp Ala Gln Cys Phe 
    290                 295                 300                 


Arg Phe Cys Val Met Met Lys Asp Lys Asn Leu Lys Ile Asp Met Arg 
305                 310                 315                 320 


Glu Thr Thr Arg Leu Trp Thr Arg Ser Ala Ser Asp Asp Ser Val Ala 
                325                 330                 335     


Thr Ser Ser Leu Ser Ile Ser Leu Asp Arg Gly Arg Trp Val Ala Ala 
            340                 345                 350         


Asp Ala Ser Asp Ala Arg Leu Leu Val Phe Pro Ile Arg Val 
        355                 360                 365     


<210>  15
<211>  365
<212>  PRT
<213>  reovirus

<400>  15

Met Glu Val Cys Leu Pro Asn Gly His Gln Val Val Asp Leu Ile Asn 
1               5                   10                  15      


Asn Ala Phe Glu Gly Arg Val Ser Ile Tyr Ser Ala Gln Glu Gly Trp 
            20                  25                  30          


Asp Lys Thr Ile Ser Ala Gln Pro Asp Met Met Val Cys Gly Gly Ala 
        35                  40                  45              


Val Val Cys Met His Cys Leu Gly Val Val Gly Ser Leu Gln Arg Lys 
    50                  55                  60                  


Leu Lys His Leu Pro His His Arg Cys Asn Gln Gln Ile Arg His Gln 
65                  70                  75                  80  


Asp Tyr Val Asp Val Gln Phe Ala Asp Arg Val Thr Ala His Trp Lys 
                85                  90                  95      


Arg Gly Met Leu Ser Phe Val Ala Gln Met His Glu Met Met Asn Asp 
            100                 105                 110         


Val Ser Pro Asp Asp Leu Asp Arg Val Arg Thr Glu Gly Gly Ser Leu 
        115                 120                 125             


Val Glu Leu Asn Arg Leu Gln Val Asp Pro Asn Ser Met Phe Arg Ser 
    130                 135                 140                 


Ile His Ser Ser Trp Thr Asp Pro Leu Gln Val Val Asp Asp Leu Asp 
145                 150                 155                 160 


Thr Lys Leu Asp Gln Tyr Trp Thr Ala Leu Asn Leu Met Ile Asp Ser 
                165                 170                 175     


Ser Asp Leu Ile Pro Asn Phe Met Met Arg Asp Pro Ser His Ala Phe 
            180                 185                 190         


Asn Gly Val Lys Leu Lys Gly Asp Ala Arg Gln Thr Gln Phe Ser Arg 
        195                 200                 205             


Thr Phe Asp Ser Arg Ser Ser Leu Glu Trp Gly Val Met Val Tyr Asp 
    210                 215                 220                 


Tyr Ser Glu Leu Asp His Asp Pro Ser Lys Gly Arg Ala Tyr Arg Lys 
225                 230                 235                 240 


Glu Leu Val Thr Pro Ala Arg Asp Phe Gly His Phe Gly Leu Ser His 
                245                 250                 255     


Tyr Ser Arg Ala Thr Thr Pro Ile Leu Gly Lys Met Pro Ala Val Phe 
            260                 265                 270         


Ser Gly Met Leu Thr Gly Asn Cys Lys Met Tyr Pro Phe Ile Lys Gly 
        275                 280                 285             


Thr Ala Lys Leu Lys Thr Val Arg Lys Leu Val Glu Ala Val Asn His 
    290                 295                 300                 


Ala Trp Gly Val Glu Lys Ile Arg Tyr Ala Leu Gly Pro Gly Gly Met 
305                 310                 315                 320 


Thr Gly Trp Tyr Asn Arg Thr Met Gln Gln Ala Pro Ile Val Leu Thr 
                325                 330                 335     


Pro Ala Ala Leu Thr Met Phe Pro Asp Thr Ile Lys Phe Gly Asp Leu 
            340                 345                 350         


Asn Tyr Pro Val Met Ile Gly Asp Pro Met Ile Leu Gly 
        355                 360                 365 


<210>  16
<211>  736
<212>  PRT
<213>  reovirus

<400>  16

Met Ala Tyr Ile Ala Val Pro Ala Val Val Asp Ser Arg Ser Ser Glu 
1               5                   10                  15      


Ala Ile Gly Leu Leu Glu Ser Phe Gly Val Asp Ala Gly Ala Asp Ala 
            20                  25                  30          


Asn Asp Val Ser Tyr Gln Asp His Asp Tyr Val Leu Asp Gln Leu Gln 
        35                  40                  45              


Tyr Met Leu Asp Gly Tyr Glu Ala Gly Asp Val Ile Asp Ala Leu Val 
    50                  55                  60                  


His Lys Asn Trp Leu His His Ser Val Tyr Cys Leu Leu Pro Pro Lys 
65                  70                  75                  80  


Ser Gln Leu Leu Glu Tyr Trp Lys Ser Asn Pro Ser Ala Ile Pro Asp 
                85                  90                  95      


Asn Val Asp Arg Arg Leu Arg Lys Arg Leu Met Leu Lys Lys Asp Leu 
            100                 105                 110         


Arg Lys Asp Asp Glu Tyr Asn Gln Leu Ala Arg Ala Phe Lys Ile Ser 
        115                 120                 125             


Asp Val Tyr Ala Pro Leu Ile Ser Ser Thr Thr Ser Pro Met Thr Met 
    130                 135                 140                 


Ile Gln Asn Leu Asn Arg Gly Glu Ile Val Tyr Thr Thr Thr Asp Arg 
145                 150                 155                 160 


Val Ile Gly Ala Arg Ile Leu Leu Tyr Ala Pro Arg Lys Tyr Tyr Ala 
                165                 170                 175     


Ser Thr Leu Ser Phe Thr Met Thr Lys Cys Ile Ile Pro Phe Gly Lys 
            180                 185                 190         


Glu Val Gly Arg Val Pro His Ser Arg Phe Asn Val Gly Thr Phe Pro 
        195                 200                 205             


Ser Ile Ala Thr Pro Lys Cys Phe Val Met Ser Gly Val Asp Ile Glu 
    210                 215                 220                 


Ser Ile Pro Asn Glu Phe Ile Lys Leu Phe Tyr Gln Arg Val Lys Ser 
225                 230                 235                 240 


Val His Ala Asn Ile Leu Asn Asp Ile Ser Pro Gln Ile Val Ser Asp 
                245                 250                 255     


Met Ile Asn Arg Lys Arg Leu Arg Val His Thr Pro Ser Asp Arg Arg 
            260                 265                 270         


Ala Ala Gln Leu Met His Leu Pro Tyr His Val Lys Arg Gly Ala Ser 
        275                 280                 285             


His Val Asp Val Tyr Lys Val Asp Val Val Asp Met Leu Phe Glu Val 
    290                 295                 300                 


Val Asp Val Ala Asp Gly Leu Arg Asn Val Ser Arg Lys Leu Thr Met 
305                 310                 315                 320 


His Thr Val Pro Val Cys Ile Leu Glu Met Leu Gly Ile Glu Ile Ala 
                325                 330                 335     


Asp Tyr Cys Ile Arg Gln Glu Asp Gly Met Leu Thr Asp Trp Phe Leu 
            340                 345                 350         


Leu Leu Thr Met Leu Ser Asp Gly Leu Thr Asp Arg Arg Thr His Cys 
        355                 360                 365             


Gln Tyr Leu Ile Asn Pro Ser Ser Val Pro Pro Asp Val Ile Leu Asn 
    370                 375                 380                 


Ile Ser Ile Thr Gly Phe Ile Asn Arg His Thr Ile Asp Val Met Pro 
385                 390                 395                 400 


Asp Ile Tyr Asp Phe Val Lys Pro Ile Gly Ala Val Leu Pro Lys Gly 
                405                 410                 415     


Ser Phe Lys Ser Thr Ile Met Arg Val Leu Asp Ser Ile Ser Ile Leu 
            420                 425                 430         


Gly Ile Gln Ile Met Pro Arg Ala His Val Val Asp Ser Asp Glu Val 
        435                 440                 445             


Gly Glu Gln Met Glu Pro Thr Phe Glu Gln Ala Val Met Glu Ile Tyr 
    450                 455                 460                 


Lys Gly Ile Ala Gly Val Asp Ser Leu Asp Asp Leu Ile Lys Trp Val 
465                 470                 475                 480 


Leu Asn Ser Asp Leu Ile Pro His Asp Asp Arg Leu Gly Gln Leu Phe 
                485                 490                 495     


Gln Ala Phe Leu Pro Leu Ala Lys Asp Leu Leu Ala Pro Met Ala Arg 
            500                 505                 510         


Lys Phe Tyr Asp Asn Ser Met Ser Glu Gly Arg Leu Leu Thr Phe Ser 
        515                 520                 525             


His Ala Asp Ser Glu Leu Leu Asn Ala Asn Tyr Phe Gly His Leu Leu 
    530                 535                 540                 


Arg Leu Lys Ile Pro Tyr Ile Thr Glu Val Asn Leu Met Ile Arg Lys 
545                 550                 555                 560 


Asn Arg Glu Gly Gly Glu Leu Phe Gln Leu Val Leu Ser Tyr Leu Tyr 
                565                 570                 575     


Lys Met Tyr Ala Thr Ser Ala Gln Pro Lys Trp Phe Gly Ser Leu Leu 
            580                 585                 590         


Arg Leu Leu Ile Cys Pro Trp Leu His Met Glu Lys Leu Ile Gly Glu 
        595                 600                 605             


Ala Asp Pro Ala Ser Thr Ser Ala Glu Ile Gly Trp His Ile Pro Arg 
    610                 615                 620                 


Glu Gln Leu Met Gln Asp Gly Trp Cys Gly Cys Glu Asp Gly Phe Ile 
625                 630                 635                 640 


Pro Tyr Val Ser Ile Arg Ala Pro Arg Leu Val Ile Glu Glu Leu Met 
                645                 650                 655     


Glu Lys Asn Trp Gly Gln Tyr His Ala Gln Val Ile Val Thr Asp Gln 
            660                 665                 670         


Leu Val Val Gly Glu Pro Arg Arg Val Ser Ala Lys Ala Val Ile Lys 
        675                 680                 685             


Gly Asn His Leu Pro Val Lys Leu Val Ser Arg Phe Ala Cys Phe Thr 
    690                 695                 700                 


Leu Thr Ala Lys Tyr Glu Met Arg Leu Ser Cys Gly His Ser Thr Gly 
705                 710                 715                 720 


Arg Gly Ala Ala Tyr Ser Ala Arg Leu Ala Phe Arg Ser Asp Leu Ala 
                725                 730                 735     


<210>  17
<211>  708
<212>  PRT
<213>  reovirus

<400>  17

Met Gly Asn Ala Ser Ser Ile Val Gln Thr Ile Asn Val Thr Gly Asp 
1               5                   10                  15      


Gly Asn Val Phe Lys Pro Ser Ala Glu Thr Ser Ser Thr Ala Val Pro 
            20                  25                  30          


Ser Leu Ser Leu Ser Pro Gly Met Leu Asn Pro Gly Gly Val Pro Trp 
        35                  40                  45              


Ile Ala Val Gly Asp Glu Thr Ser Val Thr Ser Pro Gly Ala Leu Arg 
    50                  55                  60                  


Arg Met Thr Ser Lys Asp Ile Pro Asp Thr Ala Ile Ile Asn Thr Asp 
65                  70                  75                  80  


Asn Ser Ser Gly Ala Val Pro Ser Glu Ser Ala Leu Val Pro Tyr Ile 
                85                  90                  95      


Asp Glu Pro Leu Val Val Val Thr Glu His Ala Ile Thr Asn Phe Thr 
            100                 105                 110         


Lys Ala Glu Met Ala Leu Glu Phe Asn Arg Glu Phe Leu Asp Lys Met 
        115                 120                 125             


Arg Val Leu Ser Val Ser Pro Lys Tyr Ser Asp Leu Leu Thr Tyr Val 
    130                 135                 140                 


Asp Cys Tyr Val Gly Val Ser Ala Arg Gln Ala Leu Asn Asn Phe Gln 
145                 150                 155                 160 


Lys Gln Val Pro Val Ile Thr Pro Thr Arg Gln Thr Met Tyr Val Asp 
                165                 170                 175     


Ser Ile Gln Ala Ala Leu Lys Ala Leu Glu Lys Trp Glu Ile Asp Leu 
            180                 185                 190         


Arg Val Ala Gln Thr Leu Leu Pro Thr Asn Val Pro Ile Gly Glu Val 
        195                 200                 205             


Ser Cys Pro Met Gln Ser Val Val Lys Leu Leu Asp Asp Gln Leu Pro 
    210                 215                 220                 


Asp Asp Ser Leu Ile Arg Arg Tyr Pro Lys Glu Ala Ala Val Ala Leu 
225                 230                 235                 240 


Ala Lys Arg Asn Gly Gly Ile Gln Trp Met Asp Val Ser Glu Gly Thr 
                245                 250                 255     


Val Met Asn Glu Ala Val Asn Ala Val Ala Ala Ser Ala Leu Ala Pro 
            260                 265                 270         


Ser Ala Ser Ala Pro Pro Leu Glu Glu Lys Ser Lys Leu Thr Glu Gln 
        275                 280                 285             


Ala Met Asp Leu Val Thr Ala Ala Glu Pro Glu Ile Ile Ala Ser Leu 
    290                 295                 300                 


Ala Pro Val Pro Ala Pro Val Phe Ala Ile Pro Pro Lys Pro Ala Asp 
305                 310                 315                 320 


Tyr Asn Val Arg Thr Leu Arg Ile Asp Glu Ala Thr Trp Leu Arg Met 
                325                 330                 335     


Ile Pro Lys Ser Met Asn Thr Pro Phe Gln Ile Gln Val Thr Asp Asn 
            340                 345                 350         


Thr Gly Thr Asn Trp His Leu Asn Leu Arg Gly Gly Thr Arg Val Val 
        355                 360                 365             


Asn Leu Asp Gln Ile Ala Pro Met Arg Phe Val Leu Asp Leu Gly Gly 
    370                 375                 380                 


Lys Ser Tyr Lys Glu Thr Ser Trp Asp Pro Asn Gly Lys Lys Val Gly 
385                 390                 395                 400 


Phe Ile Val Phe Gln Ser Lys Ile Pro Phe Glu Leu Trp Thr Ala Ala 
                405                 410                 415     


Ser Gln Ile Gly Gln Ala Thr Val Val Asn Tyr Val Gln Leu Tyr Ala 
            420                 425                 430         


Glu Asp Ser Ser Phe Thr Ala Gln Ser Ile Ile Ala Thr Thr Ser Leu 
        435                 440                 445             


Ala Tyr Asn Tyr Glu Pro Glu Gln Leu Asn Lys Thr Asp Pro Glu Met 
    450                 455                 460                 


Asn Tyr Tyr Leu Leu Ala Thr Phe Ile Asp Ser Ala Ala Ile Thr Pro 
465                 470                 475                 480 


Thr Asn Met Thr Gln Pro Asp Val Trp Asp Ala Leu Leu Thr Met Ser 
                485                 490                 495     


Pro Leu Ser Ala Gly Glu Val Thr Val Lys Gly Ala Val Val Ser Glu 
            500                 505                 510         


Val Val Pro Ala Asp Leu Ile Gly Ser Tyr Thr Pro Glu Ser Leu Asn 
        515                 520                 525             


Ala Ser Leu Pro Asn Asp Ala Ala Arg Cys Met Ile Asp Arg Ala Ser 
    530                 535                 540                 


Lys Ile Ala Glu Ala Ile Lys Ile Asp Asp Asp Ala Gly Pro Asp Glu 
545                 550                 555                 560 


Tyr Ser Pro Asn Ser Val Pro Ile Gln Gly Gln Leu Ala Ile Ser Gln 
                565                 570                 575     


Leu Glu Thr Gly Tyr Gly Val Arg Ile Phe Asn Pro Lys Gly Ile Leu 
            580                 585                 590         


Ser Lys Ile Ala Ser Arg Ala Met Gln Ala Phe Ile Gly Asp Pro Ser 
        595                 600                 605             


Thr Ile Ile Thr Gln Ala Ala Pro Val Leu Ser Asp Lys Asn Asn Trp 
    610                 615                 620                 


Ile Ala Leu Ala Gln Gly Val Lys Thr Ser Leu Arg Thr Lys Ser Leu 
625                 630                 635                 640 


Ser Ala Gly Val Lys Thr Ala Val Ser Lys Leu Ser Ser Ser Glu Ser 
                645                 650                 655     


Ile Gln Asn Trp Thr Gln Gly Phe Leu Asp Lys Val Ser Ala His Phe 
            660                 665                 670         


Pro Ala Pro Lys Pro Asp Cys Pro Thr Ser Gly Asp Ser Gly Glu Ser 
        675                 680                 685             


Ser Asn Arg Arg Val Lys Arg Asp Ser Tyr Ala Gly Val Val Lys Arg 
    690                 695                 700                 


Gly Tyr Thr Arg 
705             


<210>  18
<211>  721
<212>  PRT
<213>  reovirus

<400>  18

Met Ala Ser Phe Lys Gly Phe Ser Ala Asn Thr Val Pro Val Ser Lys 
1               5                   10                  15      


Ala Lys Arg Asp Ile Ser Ser Leu Ala Ala Thr Pro Gly Leu Arg Ser 
            20                  25                  30          


Gln Ser Phe Thr Pro Ser Val Asp Met Ser Gln Ser Arg Glu Phe Leu 
        35                  40                  45              


Thr Lys Ala Ile Glu Gln Gly Ser Met Ser Ile Pro Tyr Gln His Val 
    50                  55                  60                  


Asn Val Pro Lys Val Asp Arg Lys Val Val Ser Leu Val Val Arg Pro 
65                  70                  75                  80  


Phe Ser Ser Gly Ala Phe Ser Ile Ser Gly Val Ile Ser Pro Ala His 
                85                  90                  95      


Ala Tyr Leu Leu Glu Cys Leu Pro Gln Leu Glu Gln Ala Met Ala Phe 
            100                 105                 110         


Val Ala Ser Pro Glu Ser Phe Gln Ala Ser Asp Val Ala Lys Arg Phe 
        115                 120                 125             


Ala Ile Lys Pro Gly Met Ser Leu Gln Asp Ala Ile Thr Ala Phe Ile 
    130                 135                 140                 


Asn Phe Val Ser Ala Met Leu Lys Met Thr Val Thr Arg Gln Asn Phe 
145                 150                 155                 160 


Asp Val Ile Val Ala Glu Ile Glu Arg Leu Ala Ser Thr Ser Val Ser 
                165                 170                 175     


Val Arg Thr Glu Glu Ala Lys Val Ala Asp Glu Glu Leu Met Leu Phe 
            180                 185                 190         


Gly Leu Asp His Arg Gly Pro Gln Gln Leu Asp Val Ser Asp Ala Lys 
        195                 200                 205             


Gly Ile Met Lys Ala Ala Asp Ile Gln Thr Thr His Asp Val His Leu 
    210                 215                 220                 


Ala Pro Gly Val Gly Asn Ile Asp Pro Glu Ile Tyr Asn Glu Gly Arg 
225                 230                 235                 240 


Phe Met Phe Met Gln His Lys Pro Leu Ala Ala Asp Gln Ser Tyr Phe 
                245                 250                 255     


Thr Leu Glu Thr Ala Asp Tyr Phe Lys Ile Tyr Pro Thr Tyr Asp Glu 
            260                 265                 270         


His Asp Gly Arg Met Ala Asp Gln Lys Gln Ser Gly Leu Ile Leu Cys 
        275                 280                 285             


Thr Lys Asp Glu Val Leu Ala Glu Gln Thr Ile Phe Lys Leu Asp Ala 
    290                 295                 300                 


Pro Asp Asp Lys Thr Val His Leu Leu Asp Arg Asp Asp Asp His Val 
305                 310                 315                 320 


Val Ala Arg Phe Thr Lys Val Phe Ile Glu Asp Val Ala Pro Gly His 
                325                 330                 335     


His Ala Ala Gln Arg Ser Gly Gln Arg Ser Val Leu Asp Asp Leu Tyr 
            340                 345                 350         


Ala Asn Thr Gln Val Ile Ser Ile Thr Ser Ala Ala Leu Lys Trp Val 
        355                 360                 365             


Val Lys His Gly Val Ser Asp Gly Ile Val Asn Arg Lys Asn Val Lys 
    370                 375                 380                 


Val Cys Val Gly Phe Asp Pro Leu Tyr Thr Leu Ser Thr His Asn Gly 
385                 390                 395                 400 


Val Ser Leu Cys Ala Leu Leu Met Asp Glu Lys Leu Ser Val Leu Asn 
                405                 410                 415     


Ser Ala Cys Arg Met Thr Leu Arg Ser Leu Met Lys Thr Gly Arg Asp 
            420                 425                 430         


Val Asp Ala His Arg Ala Phe Gln Arg Val Leu Ser Gln Gly Tyr Thr 
        435                 440                 445             


Ser Leu Met Cys Tyr Tyr His Pro Ser Arg Lys Leu Ala Tyr Gly Glu 
    450                 455                 460                 


Val Leu Phe Leu Glu Arg Ser Asn Asp Val Thr Asp Gly Ile Lys Leu 
465                 470                 475                 480 


Gln Leu Asp Ala Ser Arg Gln Cys His Glu Cys Pro Val Leu Gln Gln 
                485                 490                 495     


Lys Val Val Glu Leu Glu Lys Gln Ile Ile Met Gln Lys Ser Ile Gln 
            500                 505                 510         


Ser Asp Pro Thr Pro Val Ala Leu Gln Pro Leu Leu Ser Gln Leu Arg 
        515                 520                 525             


Glu Leu Ser Ser Glu Val Thr Arg Leu Gln Met Glu Leu Ser Arg Ala 
    530                 535                 540                 


Gln Ser Leu Asn Ala Gln Leu Glu Ala Asp Val Lys Ser Ala Gln Ser 
545                 550                 555                 560 


Cys Ser Leu Asp Met Tyr Leu Arg His His Thr Cys Ile Asn Gly His 
                565                 570                 575     


Ala Lys Glu Asp Glu Leu Leu Asp Ala Val Arg Val Ala Pro Asp Val 
            580                 585                 590         


Arg Arg Glu Ile Met Glu Lys Arg Ser Glu Val Arg Gln Gly Trp Cys 
        595                 600                 605             


Glu Arg Ile Ser Lys Glu Ala Ala Ala Lys Cys Gln Thr Val Ile Asp 
    610                 615                 620                 


Asp Leu Thr Leu Met Asn Gly Lys Gln Ala Gln Glu Ile Thr Glu Leu 
625                 630                 635                 640 


Arg Asp Ser Ala Glu Lys Tyr Glu Lys Gln Ile Ala Glu Leu Val Ser 
                645                 650                 655     


Thr Ile Thr Gln Asn Gln Ile Thr Tyr Gln Gln Glu Leu Gln Ala Leu 
            660                 665                 670         


Val Ala Lys Asn Val Glu Leu Asp Ala Leu Asn Gln Arg Gln Ala Lys 
        675                 680                 685             


Ser Leu Arg Ile Thr Pro Ser Leu Leu Ser Ala Thr Pro Ile Asp Ser 
    690                 695                 700                 


Val Asp Asp Val Ala Asp Leu Ile Asp Phe Ser Val Pro Thr Asp Glu 
705                 710                 715                 720 


Leu 
    


<210>  19
<211>  1267
<212>  PRT
<213>  reovirus

<400>  19

Met Ser Ser Met Ile Leu Thr Gln Phe Gly Pro Phe Ile Glu Ser Ile 
1               5                   10                  15      


Ser Gly Ile Thr Asp Gln Ser Asn Asp Val Phe Glu Asp Ala Ala Lys 
            20                  25                  30          


Ala Phe Ser Met Phe Thr Arg Ser Asp Val Tyr Lys Ala Leu Asp Glu 
        35                  40                  45              


Ile Pro Phe Ser Asp Asp Ala Met Leu Pro Ile Pro Pro Thr Ile Tyr 
    50                  55                  60                  


Thr Lys Pro Ser His Asp Ser Tyr Tyr Tyr Ile Asp Ala Leu Asn Arg 
65                  70                  75                  80  


Val Arg Arg Lys Thr Tyr Gln Gly Pro Asp Asp Val Tyr Val Pro Asn 
                85                  90                  95      


Cys Ser Ile Val Glu Leu Leu Glu Pro His Glu Thr Leu Thr Ser Tyr 
            100                 105                 110         


Gly Arg Leu Ser Glu Ala Ile Glu Asn Arg Ala Lys Asp Gly Asp Ser 
        115                 120                 125             


Gln Ala Arg Ile Ala Thr Thr Tyr Gly Arg Ile Ala Glu Ser Gln Ala 
    130                 135                 140                 


Arg Gln Ile Lys Ala Pro Leu Glu Lys Phe Val Leu Ala Leu Leu Val 
145                 150                 155                 160 


Ala Glu Ala Gly Gly Ser Leu Tyr Asp Pro Val Leu Gln Lys Tyr Asp 
                165                 170                 175     


Glu Ile Pro Asp Leu Ser His Asn Cys Pro Leu Trp Cys Phe Arg Glu 
            180                 185                 190         


Ile Cys Arg His Ile Ser Gly Pro Leu Pro Asp Arg Ala Pro Tyr Leu 
        195                 200                 205             


Tyr Leu Ser Ala Gly Val Phe Trp Leu Met Ser Pro Arg Met Thr Ser 
    210                 215                 220                 


Ala Ile Pro Pro Leu Leu Ser Asp Leu Val Asn Leu Ala Ile Leu Gln 
225                 230                 235                 240 


Gln Thr Ala Gly Leu Asp Pro Ser Leu Val Lys Leu Gly Val Gln Ile 
                245                 250                 255     


Cys Leu His Ala Ala Ala Ser Ser Ser Tyr Ala Trp Phe Ile Leu Lys 
            260                 265                 270         


Thr Lys Ser Ile Phe Pro Gln Asn Thr Leu His Ser Met Tyr Glu Ser 
        275                 280                 285             


Leu Glu Gly Gly Tyr Cys Pro Asn Leu Glu Trp Leu Glu Pro Arg Ser 
    290                 295                 300                 


Asp Tyr Lys Phe Met Tyr Met Gly Val Met Pro Leu Ser Ala Lys Tyr 
305                 310                 315                 320 


Ala Arg Ser Ala Pro Ser Asn Asp Lys Lys Ala Arg Glu Leu Gly Glu 
                325                 330                 335     


Lys Tyr Gly Leu Ser Ser Val Val Gly Glu Leu Arg Lys Arg Thr Lys 
            340                 345                 350         


Thr Tyr Val Lys His Asp Phe Ala Ser Val Arg Tyr Ile Arg Asp Ala 
        355                 360                 365             


Met Ala Cys Thr Ser Gly Ile Phe Leu Val Arg Thr Pro Thr Glu Thr 
    370                 375                 380                 


Val Leu Gln Glu Tyr Thr Gln Ser Pro Glu Ile Lys Val Pro Ile Pro 
385                 390                 395                 400 


Gln Lys Asp Trp Thr Gly Pro Ile Gly Glu Ile Arg Ile Leu Lys Asp 
                405                 410                 415     


Thr Thr Ser Ser Ile Ala Arg Tyr Leu Tyr Arg Thr Trp Tyr Leu Ala 
            420                 425                 430         


Ala Ala Arg Met Ala Ala Gln Pro Arg Thr Trp Asp Pro Leu Phe Gln 
        435                 440                 445             


Ala Ile Met Arg Ser Gln Tyr Val Thr Ala Arg Gly Gly Ser Gly Ala 
    450                 455                 460                 


Ala Leu Arg Glu Ser Leu Tyr Ala Ile Asn Val Ser Leu Pro Asp Phe 
465                 470                 475                 480 


Lys Gly Leu Pro Val Lys Ala Ala Thr Lys Ile Phe Gln Ala Ala Gln 
                485                 490                 495     


Leu Ala Asn Leu Pro Phe Ser His Thr Ser Val Ala Ile Leu Ala Asp 
            500                 505                 510         


Thr Ser Met Gly Leu Arg Asn Gln Val Gln Arg Arg Pro Arg Ser Ile 
        515                 520                 525             


Met Pro Leu Asn Val Pro Gln Gln Gln Val Ser Ala Pro His Thr Leu 
    530                 535                 540                 


Thr Ala Asp Tyr Ile Asn Tyr His Met Asn Leu Ser Thr Thr Ser Gly 
545                 550                 555                 560 


Ser Ala Val Ile Glu Lys Val Ile Pro Leu Gly Val Tyr Ala Ser Ser 
                565                 570                 575     


Pro Pro Asn Gln Ser Ile Asn Ile Asp Ile Ser Ala Cys Asp Ala Ser 
            580                 585                 590         


Ile Thr Trp Asp Phe Phe Leu Ser Val Ile Met Ala Ala Ile His Glu 
        595                 600                 605             


Gly Val Ala Ser Ser Ser Ile Gly Lys Pro Phe Met Gly Val Pro Ala 
    610                 615                 620                 


Ser Ile Val Asn Asp Glu Ser Val Val Gly Val Arg Ala Ala Arg Pro 
625                 630                 635                 640 


Ile Ser Gly Met Gln Asn Met Ile Gln His Leu Ser Lys Leu Tyr Lys 
                645                 650                 655     


Arg Gly Phe Ser Tyr Arg Val Asn Asp Ser Phe Ser Pro Gly Asn Asp 
            660                 665                 670         


Phe Thr His Met Thr Thr Thr Phe Pro Ser Gly Ser Thr Ala Thr Ser 
        675                 680                 685             


Thr Glu His Thr Ala Asn Asn Ser Thr Met Met Glu Thr Phe Leu Thr 
    690                 695                 700                 


Val Trp Gly Pro Glu His Thr Asp Asp Pro Asp Val Leu Arg Leu Met 
705                 710                 715                 720 


Lys Ser Leu Thr Ile Gln Arg Asn Tyr Val Cys Gln Gly Asp Asp Gly 
                725                 730                 735     


Leu Met Ile Ile Asp Gly Thr Thr Ala Gly Lys Val Asn Ser Glu Thr 
            740                 745                 750         


Ile Gln Lys Met Leu Glu Leu Ile Ser Lys Tyr Gly Glu Glu Phe Gly 
        755                 760                 765             


Trp Lys Tyr Asp Ile Ala Tyr Asp Gly Thr Ala Glu Tyr Leu Lys Leu 
    770                 775                 780                 


Tyr Phe Ile Phe Gly Cys Arg Ile Pro Asn Leu Ser Arg His Pro Ile 
785                 790                 795                 800 


Val Gly Lys Glu Arg Ala Asn Ser Ser Ala Glu Glu Pro Trp Pro Ala 
                805                 810                 815     


Ile Leu Asp Gln Ile Met Gly Val Phe Phe Asn Gly Val His Asp Gly 
            820                 825                 830         


Leu Gln Trp Gln Arg Trp Ile Arg Tyr Ser Trp Ala Leu Cys Cys Ala 
        835                 840                 845             


Phe Ser Arg Gln Arg Thr Met Ile Gly Glu Ser Val Gly Tyr Leu Gln 
    850                 855                 860                 


Tyr Pro Met Trp Ser Phe Val Tyr Trp Gly Leu Pro Leu Val Lys Ala 
865                 870                 875                 880 


Phe Gly Ser Asp Pro Trp Ile Phe Ser Trp Tyr Met Pro Thr Gly Asp 
                885                 890                 895     


Leu Gly Met Tyr Ser Trp Ile Ser Leu Ile Arg Pro Leu Met Thr Arg 
            900                 905                 910         


Trp Met Val Ala Asn Gly Tyr Val Thr Asp Arg Cys Ser Pro Val Phe 
        915                 920                 925             


Gly Asn Ala Asp Tyr Arg Arg Cys Phe Asn Glu Leu Lys Leu Tyr Gln 
    930                 935                 940                 


Gly Tyr Tyr Met Ala Gln Leu Pro Arg Asn Pro Lys Lys Ser Gly Arg 
945                 950                 955                 960 


Ala Ala Pro Arg Glu Val Arg Glu Gln Phe Thr Gln Ala Leu Ser Asp 
                965                 970                 975     


Tyr Leu Leu Gln Asn Pro Glu Leu Lys Ser Arg Val Leu Arg Gly Arg 
            980                 985                 990         


Ser Glu Trp Glu Lys Tyr Gly Ala  Gly Ile Ile His Asn  Pro Pro Ser 
        995                 1000                 1005             


Leu Phe  Asp Val Pro His Lys  Trp Tyr Gln Gly Ala  Gln Glu Ala 
    1010                 1015                 1020             


Ala Ile  Ala Thr Arg Glu Glu  Leu Ala Glu Met Asp  Glu Thr Leu 
    1025                 1030                 1035             


Met Arg  Ala Arg Arg His Arg  Tyr Ser Ser Phe Ser  Lys Leu Leu 
    1040                 1045                 1050             


Glu Ala  Tyr Leu Leu Val Lys  Trp Arg Met Cys Glu  Ala Arg Glu 
    1055                 1060                 1065             


Pro Ser  Val Asp Leu Arg Leu  Pro Leu Cys Ala Gly  Ile Asp Pro 
    1070                 1075                 1080             


Leu Asn  Ser Asp Pro Phe Leu  Lys Met Val Ser Val  Gly Pro Met 
    1085                 1090                 1095             


Leu Gln  Ser Thr Arg Lys Tyr  Phe Ala Gln Thr Leu  Phe Met Ala 
    1100                 1105                 1110             


Lys Thr  Val Ser Gly Leu Asp  Val Asn Ala Ile Asp  Ser Ala Leu 
    1115                 1120                 1125             


Leu Arg  Leu Arg Thr Leu Gly  Ala Asp Lys Lys Ala  Leu Thr Ala 
    1130                 1135                 1140             


Gln Leu  Leu Met Val Gly Leu  Gln Glu Ser Glu Ala  Asp Ala Leu 
    1145                 1150                 1155             


Ala Gly  Lys Ile Met Leu Gln  Asp Val Asn Thr Val  Gln Leu Ala 
    1160                 1165                 1170             


Arg Val  Val Asn Leu Ala Val  Pro Asp Thr Trp Met  Ser Leu Asp 
    1175                 1180                 1185             


Phe Asp  Ser Met Phe Lys His  His Val Lys Leu Leu  Pro Lys Asp 
    1190                 1195                 1200             


Gly Arg  His Leu Asn Thr Asp  Ile Pro Pro Arg Met  Gly Trp Leu 
    1205                 1210                 1215             


Arg Ala  Ile Leu Arg Phe Leu  Gly Ala Gly Met Val  Met Thr Ala 
    1220                 1225                 1230             


Thr Gly  Val Ala Val Asp Ile  Tyr Leu Glu Asp Ile  His Gly Gly 
    1235                 1240                 1245             


Gly Arg  Ser Leu Gly Gln Arg  Phe Met Thr Trp Met  Arg Gln Glu 
    1250                 1255                 1260             


Gly Arg  Ser Ala 
    1265         


<210>  20
<211>  1289
<212>  PRT
<213>  reovirus

<400>  20

Met Ala Asn Val Trp Gly Val Arg Leu Ala Asp Ser Leu Ser Ser Pro 
1               5                   10                  15      


Thr Ile Glu Thr Arg Thr Arg Gln Tyr Thr Leu His Asp Leu Cys Ser 
            20                  25                  30          


Asp Leu Asp Ala Asn Pro Gly Arg Glu Pro Trp Lys Pro Leu Arg Asn 
        35                  40                  45              


Gln Arg Thr Asn Asn Ile Val Ala Val Gln Leu Phe Arg Pro Leu Gln 
    50                  55                  60                  


Gly Leu Val Leu Asp Thr Gln Leu Tyr Gly Phe Pro Gly Ala Phe Asp 
65                  70                  75                  80  


Asp Trp Glu Arg Phe Met Arg Glu Lys Leu Arg Val Leu Lys Tyr Glu 
                85                  90                  95      


Val Leu Arg Ile Tyr Pro Ile Ser Asn Tyr Ser Asn Glu His Val Asn 
            100                 105                 110         


Val Phe Val Ala Asn Ala Leu Val Gly Ala Phe Leu Ser Asn Gln Ala 
        115                 120                 125             


Phe Tyr Asp Leu Leu Pro Leu Leu Ile Ile Asn Asp Thr Met Ile Gly 
    130                 135                 140                 


Asp Leu Leu Gly Thr Gly Ala Ser Leu Ser Gln Phe Phe Gln Ser His 
145                 150                 155                 160 


Gly Asp Val Leu Glu Val Ala Ala Gly Arg Lys Tyr Leu Gln Met Glu 
                165                 170                 175     


Asn Tyr Ser Asn Asp Asp Asp Asp Pro Pro Leu Phe Ala Lys Asp Leu 
            180                 185                 190         


Ser Asp Tyr Ala Lys Ala Phe Tyr Ser Asp Thr Tyr Glu Val Leu Asp 
        195                 200                 205             


Arg Phe Phe Trp Thr His Asp Ser Ser Ala Gly Val Leu Val His Tyr 
    210                 215                 220                 


Asp Lys Pro Thr Asn Gly His His Tyr Leu Leu Gly Thr Leu Thr Gln 
225                 230                 235                 240 


Met Val Ser Ala Pro Pro Tyr Ile Ile Asn Ala Thr Asp Ala Met Leu 
                245                 250                 255     


Leu Glu Ser Cys Leu Glu Gln Phe Ser Ala Asn Val Arg Ala Arg Pro 
            260                 265                 270         


Ala Gln Pro Val Thr Arg Leu Asp Gln Cys Tyr His Leu Arg Trp Gly 
        275                 280                 285             


Ala Gln Tyr Val Gly Glu Asp Ser Leu Thr Tyr Arg Leu Gly Val Leu 
    290                 295                 300                 


Ser Leu Leu Ala Thr Asn Gly Tyr Gln Leu Ala Arg Pro Ile Pro Arg 
305                 310                 315                 320 


Gln Leu Thr Asn Arg Trp Leu Ser Ser Phe Val Ser Gln Ile Met Ser 
                325                 330                 335     


Asp Gly Val Asn Glu Thr Pro Leu Trp Pro Gln Glu Arg Tyr Val Gln 
            340                 345                 350         


Ile Ala Tyr Asp Ser Pro Ser Val Val Asp Gly Ala Thr Gln Tyr Gly 
        355                 360                 365             


Tyr Val Arg Lys Asn Gln Leu Arg Leu Gly Met Arg Ile Ser Ala Leu 
    370                 375                 380                 


Gln Ser Leu Ser Asp Thr Pro Ser Pro Val Gln Trp Leu Pro Gln Tyr 
385                 390                 395                 400 


Thr Ile Asp Gln Ala Ala Met Asp Glu Gly Asp Leu Met Val Ser Arg 
                405                 410                 415     


Leu Thr Gln Leu Pro Leu Arg Pro Asp Tyr Gly Asn Ile Trp Val Gly 
            420                 425                 430         


Asp Ala Leu Ser Tyr Tyr Val Asp Tyr Asn Arg Ser His Arg Val Val 
        435                 440                 445             


Leu Ser Ser Glu Leu Pro Gln Leu Pro Asp Thr Tyr Phe Asp Gly Asp 
    450                 455                 460                 


Glu Gln Tyr Gly Arg Ser Leu Phe Ser Leu Ala Arg Lys Ile Gly Asp 
465                 470                 475                 480 


Arg Ser Leu Val Lys Asp Thr Ala Val Leu Lys His Ala Tyr Gln Ala 
                485                 490                 495     


Ile Asp Pro Asn Thr Gly Lys Glu Tyr Leu Arg Ser Arg Gln Ser Val 
            500                 505                 510         


Ala Tyr Phe Gly Ala Ser Ala Gly His Ser Gly Ala Asp Gln Pro Leu 
        515                 520                 525             


Val Ile Glu Pro Trp Ile Gln Gly Lys Ile Ser Gly Val Pro Pro Pro 
    530                 535                 540                 


Ser Ser Val Arg Gln Phe Gly Tyr Asp Val Ala Arg Gly Ala Ile Val 
545                 550                 555                 560 


Asp Leu Ala Arg Pro Phe Pro Ser Gly Asp Tyr Gln Phe Val Tyr Ser 
                565                 570                 575     


Asp Val Asp Gln Val Val Asp Gly His Asp Asp Leu Ser Ile Ser Ser 
            580                 585                 590         


Gly Leu Val Glu Ser Leu Leu Ser Ser Cys Met His Ala Thr Ala Pro 
        595                 600                 605             


Gly Gly Ser Phe Val Val Lys Ile Asn Phe Pro Thr Arg Pro Val Trp 
    610                 615                 620                 


His Tyr Ile Glu Gln Lys Ile Leu Pro Asn Ile Thr Ser Tyr Met Leu 
625                 630                 635                 640 


Ile Lys Pro Phe Val Thr Asn Asn Val Glu Leu Phe Phe Val Ala Phe 
                645                 650                 655     


Gly Val His Gln His Ser Ser Leu Thr Trp Thr Ser Gly Val Tyr Phe 
            660                 665                 670         


Phe Leu Val Asp His Phe Tyr Arg Tyr Glu Thr Leu Ser Thr Ile Ser 
        675                 680                 685             


Arg Gln Leu Pro Ser Phe Gly Tyr Val Asp Asp Gly Ser Ser Val Thr 
    690                 695                 700                 


Gly Ile Glu Thr Ile Ser Ile Glu Asn Pro Gly Phe Ser Asn Met Thr 
705                 710                 715                 720 


Gln Ala Ala Arg Ile Gly Ile Ser Gly Leu Cys Ala Asn Val Gly Asn 
                725                 730                 735     


Ala Arg Lys Ser Ile Ala Ile Tyr Glu Ser His Gly Ala Arg Val Leu 
            740                 745                 750         


Thr Ile Thr Ser Arg Arg Ser Pro Ala Ser Ala Arg Arg Lys Ser Arg 
        755                 760                 765             


Leu Arg Tyr Leu Pro Leu Ile Asp Pro Arg Ser Leu Glu Val Gln Ala 
    770                 775                 780                 


Arg Thr Ile Leu Pro Ala Asp Pro Val Leu Phe Glu Asn Val Ser Gly 
785                 790                 795                 800 


Ala Ser Pro His Val Cys Leu Thr Met Met Tyr Asn Phe Glu Val Ser 
                805                 810                 815     


Ser Ala Val Tyr Asp Gly Asp Val Val Leu Asp Leu Gly Thr Gly Pro 
            820                 825                 830         


Glu Ala Lys Ile Leu Glu Leu Ile Pro Ala Thr Ser Pro Val Thr Cys 
        835                 840                 845             


Val Asp Ile Arg Pro Thr Ala Gln Pro Ser Gly Cys Trp Asn Val Arg 
    850                 855                 860                 


Thr Thr Phe Leu Glu Leu Asp Tyr Leu Ser Asp Gly Trp Ile Thr Gly 
865                 870                 875                 880 


Val Arg Gly Asp Ile Val Thr Cys Met Leu Ser Leu Gly Ala Ala Ala 
                885                 890                 895     


Ala Gly Lys Ser Met Thr Phe Asp Ala Ala Phe Gln Gln Leu Ile Lys 
            900                 905                 910         


Val Leu Ser Lys Ser Thr Ala Asn Val Val Leu Val Gln Val Asn Cys 
        915                 920                 925             


Pro Thr Asp Val Val Arg Ser Ile Lys Gly Tyr Leu Glu Ile Asp Ser 
    930                 935                 940                 


Thr Asn Lys Arg Tyr Arg Phe Pro Lys Phe Gly Arg Asp Glu Pro Tyr 
945                 950                 955                 960 


Ser Asp Met Asp Ala Leu Glu Lys Ile Cys Arg Thr Ala Trp Pro Asn 
                965                 970                 975     


Cys Ser Ile Thr Trp Val Pro Leu Ser Tyr Asp Leu Arg Trp Thr Arg 
            980                 985                 990         


Leu Ala Leu Leu Glu Ser Thr Thr  Leu Ser Ser Ala Ser  Ile Arg Ile 
        995                 1000                 1005             


Ala Glu  Leu Met Tyr Lys Tyr  Met Pro Ile Met Arg  Ile Asp Ile 
    1010                 1015                 1020             


His Gly  Leu Pro Met Glu Lys  Arg Gly Asn Phe Ile  Val Gly Gln 
    1025                 1030                 1035             


Asn Cys  Ser Leu Val Ile Pro  Gly Phe Asn Ala Gln  Asp Val Phe 
    1040                 1045                 1050             


Asn Cys  Tyr Phe Asn Ser Ala  Leu Ala Phe Ser Thr  Glu Asp Val 
    1055                 1060                 1065             


Asn Ala  Ala Met Ile Pro Gln  Val Ser Ala Gln Phe  Asp Ala Thr 
    1070                 1075                 1080             


Lys Gly  Glu Trp Thr Leu Asp  Met Val Phe Ser Asp  Ala Gly Ile 
    1085                 1090                 1095             


Tyr Thr  Met Gln Ala Leu Val  Gly Ser Asn Ala Asn  Pro Val Ser 
    1100                 1105                 1110             


Leu Gly  Ser Phe Val Val Asp  Ser Pro Asp Val Asp  Ile Thr Asp 
    1115                 1120                 1125             


Ala Trp  Pro Ala Gln Leu Asp  Phe Thr Ile Ala Gly  Thr Asp Val 
    1130                 1135                 1140             


Asp Ile  Thr Val Asn Pro Tyr  Tyr Arg Leu Met Thr  Phe Val Arg 
    1145                 1150                 1155             


Ile Asp  Gly Gln Trp Gln Ile  Ala Asn Pro Asp Lys  Phe Gln Phe 
    1160                 1165                 1170             


Phe Ser  Ser Ala Ser Gly Thr  Leu Val Met Asn Val  Lys Leu Asp 
    1175                 1180                 1185             


Ile Ala  Asp Lys Tyr Leu Leu  Tyr Tyr Ile Arg Asp  Val Gln Ser 
    1190                 1195                 1200             


Arg Asp  Val Gly Phe Tyr Ile  Gln His Pro Leu Gln  Leu Leu Asn 
    1205                 1210                 1215             


Thr Ile  Thr Leu Pro Thr Asn  Glu Asp Leu Phe Leu  Ser Ala Pro 
    1220                 1225                 1230             


Asp Met  Arg Glu Trp Ala Val  Lys Glu Ser Gly Asn  Thr Ile Cys 
    1235                 1240                 1245             


Ile Leu  Asn Ser Gln Gly Phe  Val Leu Pro Gln Asp  Trp Asp Val 
    1250                 1255                 1260             


Leu Thr  Asp Thr Ile Ser Trp  Ser Pro Ser Ile Pro  Thr Tyr Ile 
    1265                 1270                 1275             


Val Pro  Pro Gly Asp Tyr Thr  Leu Thr Pro Leu 
    1280                 1285                 


<210>  21
<211>  1275
<212>  PRT
<213>  reovirus

<400>  21

Met Lys Arg Ile Pro Arg Lys Thr Lys Gly Lys Ser Ser Gly Lys Gly 
1               5                   10                  15      


Asn Asp Ser Thr Glu Arg Ala Asp Asp Gly Ser Ser Gln Leu Arg Asp 
            20                  25                  30          


Lys Gln Asn Asn Lys Ala Gly Pro Ala Thr Thr Glu Pro Gly Thr Ser 
        35                  40                  45              


Asn Arg Glu Gln Tyr Lys Ala Arg Pro Gly Ile Ala Ser Val Gln Arg 
    50                  55                  60                  


Ala Thr Glu Ser Ala Glu Met Pro Met Lys Asn Asn Asp Glu Gly Thr 
65                  70                  75                  80  


Pro Asp Lys Lys Gly Asn Thr Lys Gly Asp Leu Val Asn Glu His Ser 
                85                  90                  95      


Glu Ala Lys Asp Glu Ala Asp Glu Ala Thr Lys Lys Gln Ala Lys Asp 
            100                 105                 110         


Thr Asp Lys Ser Lys Ala Gln Val Thr Tyr Ser Asp Thr Gly Ile Asn 
        115                 120                 125             


Asn Ala Asn Glu Leu Ser Arg Ser Gly Asn Val Asp Asn Glu Gly Gly 
    130                 135                 140                 


Ser Asn Gln Lys Pro Met Ser Thr Arg Ile Ala Glu Ala Thr Ser Ala 
145                 150                 155                 160 


Ile Val Ser Lys His Pro Ala Arg Val Gly Leu Pro Pro Thr Ala Ser 
                165                 170                 175     


Ser Gly His Gly Tyr Gln Cys His Val Cys Ser Ala Val Leu Phe Ser 
            180                 185                 190         


Pro Leu Asp Leu Asp Ala His Val Ala Ser His Gly Leu His Gly Asn 
        195                 200                 205             


Met Thr Leu Thr Ser Ser Asp Ile Gln Arg His Ile Thr Glu Phe Ile 
    210                 215                 220                 


Ser Ser Trp Gln Asn His Pro Ile Val Gln Val Ser Ala Asp Val Glu 
225                 230                 235                 240 


Asn Lys Lys Thr Ala Gln Leu Leu His Ala Asp Thr Pro Arg Leu Val 
                245                 250                 255     


Thr Trp Asp Ala Gly Leu Cys Thr Ser Phe Lys Ile Val Pro Ile Val 
            260                 265                 270         


Pro Ala Gln Val Pro Gln Asp Val Leu Ala Tyr Thr Phe Phe Thr Ser 
        275                 280                 285             


Ser Tyr Ala Ile Gln Ser Pro Phe Pro Glu Ala Ala Val Ser Arg Ile 
    290                 295                 300                 


Val Val His Thr Arg Trp Ala Ser Asn Val Asp Phe Asp Arg Asp Ser 
305                 310                 315                 320 


Ser Val Ile Met Ala Pro Pro Thr Glu Asn Asn Ile His Leu Phe Lys 
                325                 330                 335     


Gln Leu Leu Asn Thr Glu Thr Leu Ser Val Arg Gly Ala Asn Pro Leu 
            340                 345                 350         


Met Phe Arg Ala Asn Val Leu His Met Leu Leu Glu Phe Val Leu Asp 
        355                 360                 365             


Asn Leu Tyr Leu Asn Arg His Thr Gly Phe Ser Gln Asp His Thr Pro 
    370                 375                 380                 


Phe Thr Glu Gly Ala Asn Leu Arg Ser Leu Pro Gly Pro Asp Ala Glu 
385                 390                 395                 400 


Lys Trp Tyr Ser Ile Met Tyr Pro Thr Arg Met Gly Thr Pro Asn Val 
                405                 410                 415     


Ser Lys Ile Cys Asn Phe Val Ala Ser Cys Val Arg Asn Arg Val Gly 
            420                 425                 430         


Arg Phe Asp Arg Ala Gln Met Met Asn Gly Ala Met Ser Glu Trp Val 
        435                 440                 445             


Asp Val Phe Glu Thr Ser Asp Ala Leu Thr Val Ser Ile Arg Gly Arg 
    450                 455                 460                 


Trp Met Ala Arg Leu Ala Arg Met Asn Ile Asn Pro Thr Glu Ile Glu 
465                 470                 475                 480 


Trp Ala Leu Thr Glu Cys Ala Gln Gly Tyr Val Thr Val Thr Ser Pro 
                485                 490                 495     


Tyr Ala Pro Ser Val Asn Arg Leu Met Pro Tyr Arg Ile Ser Asn Ala 
            500                 505                 510         


Glu Arg Gln Ile Ser Gln Ile Ile Arg Ile Met Asn Ile Gly Asn Asn 
        515                 520                 525             


Ala Thr Val Ile Gln Pro Val Leu Gln Asp Ile Ser Val Leu Leu Gln 
    530                 535                 540                 


Arg Ile Ser Pro Leu Gln Ile Asp Pro Thr Ile Ile Ser Asn Thr Met 
545                 550                 555                 560 


Ser Thr Val Ser Glu Ser Thr Thr Gln Thr Leu Ser Pro Ala Ser Ser 
                565                 570                 575     


Ile Leu Gly Lys Leu Arg Pro Ser Asn Ser Asp Phe Ser Ser Phe Arg 
            580                 585                 590         


Val Ala Leu Ala Gly Trp Leu Tyr Asn Gly Val Val Thr Thr Val Ile 
        595                 600                 605             


Asp Asp Ser Ser Tyr Pro Lys Asp Gly Gly Ser Val Thr Ser Leu Glu 
    610                 615                 620                 


Asn Leu Trp Asp Phe Phe Ile Leu Ala Leu Ala Leu Pro Leu Thr Thr 
625                 630                 635                 640 


Asp Pro Cys Ala Pro Val Lys Ala Phe Met Thr Leu Ala Asn Met Met 
                645                 650                 655     


Val Gly Phe Glu Thr Ile Pro Met Asp Asn Gln Ile Tyr Thr Gln Ser 
            660                 665                 670         


Arg Arg Ala Ser Ala Phe Ser Thr Pro His Thr Trp Pro Arg Cys Phe 
        675                 680                 685             


Met Asn Ile Gln Leu Ile Ser Pro Ile Asp Ala Pro Ile Leu Arg Gln 
    690                 695                 700                 


Trp Ala Glu Ile Ile His Arg Tyr Trp Pro Asn Pro Ser Gln Ile Arg 
705                 710                 715                 720 


Tyr Gly Ala Pro Asn Val Phe Gly Ser Ala Asn Leu Phe Thr Pro Pro 
                725                 730                 735     


Glu Val Leu Leu Leu Pro Ile Asp His Gln Pro Ala Asn Val Thr Thr 
            740                 745                 750         


Pro Thr Leu Asp Phe Thr Asn Glu Leu Thr Asn Trp Arg Ala Arg Val 
        755                 760                 765             


Cys Glu Leu Met Lys Asn Leu Val Asp Asn Gln Arg Tyr Gln Pro Gly 
    770                 775                 780                 


Trp Thr Gln Ser Leu Val Ser Ser Met Arg Gly Thr Leu Asp Lys Leu 
785                 790                 795                 800 


Lys Leu Ile Lys Ser Met Thr Pro Met Tyr Leu Gln Gln Leu Ala Pro 
                805                 810                 815     


Val Glu Leu Ala Val Ile Ala Pro Met Leu Pro Phe Pro Pro Phe Gln 
            820                 825                 830         


Val Pro Tyr Val Arg Leu Asp Arg Asp Arg Val Pro Thr Met Val Gly 
        835                 840                 845             


Val Thr Arg His Ser Arg Asp Thr Ile Thr Gln Pro Ala Leu Ser Leu 
    850                 855                 860                 


Ser Thr Thr Asn Thr Thr Val Gly Val Pro Leu Ala Leu Asp Ala Arg 
865                 870                 875                 880 


Ala Ile Thr Val Ala Leu Leu Ser Gly Lys Tyr Pro Pro Asp Leu Val 
                885                 890                 895     


Thr Asn Val Trp Tyr Ala Asp Ala Ile Tyr Pro Met Tyr Ala Asp Thr 
            900                 905                 910         


Glu Val Phe Ser Asn Leu Gln Arg Asp Met Ile Thr Cys Glu Ala Val 
        915                 920                 925             


Gln Thr Leu Val Thr Leu Val Ala Gln Ile Ser Glu Thr Gln Tyr Pro 
    930                 935                 940                 


Val Asp Arg Tyr Leu Asp Trp Ile Pro Ser Leu Arg Ala Ser Ala Ala 
945                 950                 955                 960 


Thr Ala Ala Thr Phe Ala Glu Trp Val Asn Thr Ser Met Lys Thr Ala 
                965                 970                 975     


Phe Asp Leu Ser Asp Met Leu Leu Glu Pro Leu Leu Ser Gly Asp Pro 
            980                 985                 990         


Arg Met Thr Gln Leu Ala Ile Gln  Tyr Gln Gln Tyr Asn  Gly Arg Thr 
        995                 1000                 1005             


Phe Asn  Ile Ile Pro Glu Met  Pro Gly Ser Val Ile  Ala Asp Cys 
    1010                 1015                 1020             


Val Gln  Leu Thr Ala Glu Val  Phe Asn His Glu Tyr  Asn Leu Phe 
    1025                 1030                 1035             


Gly Ile  Ala Arg Gly Asp Ile  Ile Ile Gly Arg Val  Gln Ser Thr 
    1040                 1045                 1050             


His Leu  Trp Ser Pro Leu Ala  Pro Pro Pro Asp Leu  Val Phe Asp 
    1055                 1060                 1065             


Arg Asp  Thr Pro Gly Val His  Ile Phe Gly Arg Asp  Cys Arg Ile 
    1070                 1075                 1080             


Ser Phe  Gly Met Asn Gly Ala  Ala Pro Met Ile Arg  Asp Glu Thr 
    1085                 1090                 1095             


Gly Leu  Met Val Pro Phe Glu  Gly Asn Trp Ile Phe  Pro Leu Ala 
    1100                 1105                 1110             


Leu Trp  Gln Met Asn Thr Arg  Tyr Phe Asn Gln Gln  Phe Asp Ala 
    1115                 1120                 1125             


Trp Ile  Lys Thr Gly Glu Leu  Arg Ile Arg Ile Glu  Met Gly Ala 
    1130                 1135                 1140             


Tyr Pro  Tyr Met Leu His Tyr  Tyr Asp Pro Arg Gln  Tyr Ala Asn 
    1145                 1150                 1155             


Ala Trp  Asn Leu Thr Ser Ala  Trp Leu Glu Glu Ile  Thr Pro Thr 
    1160                 1165                 1170             


Ser Ile  Pro Ser Val Pro Phe  Met Val Pro Ile Ser  Ser Asp His 
    1175                 1180                 1185             


Asp Ile  Ser Ser Ala Pro Ala  Val Gln Tyr Ile Ile  Ser Thr Glu 
    1190                 1195                 1200             


Tyr Asn  Asp Arg Ser Leu Phe  Cys Thr Asn Ser Ser  Ser Pro Gln 
    1205                 1210                 1215             


Thr Ile  Ala Gly Pro Asp Lys  His Ile Pro Val Glu  Arg Tyr Asn 
    1220                 1225                 1230             


Ile Leu  Thr Asn Pro Asp Ala  Pro Pro Thr Gln Ile  Gln Leu Pro 
    1235                 1240                 1245             


Glu Val  Val Asp Leu Tyr Asn  Val Val Thr Arg Tyr  Ala Tyr Glu 
    1250                 1255                 1260             


Thr Pro  Pro Ile Thr Ala Val  Val Met Gly Val Pro  
    1265                 1270                 1275 


<210>  22
<211>  3854
<212>  DNA
<213>  reovirus

<400>  22
gctacacgtt ccacgacaat gtcatccatg atactgactc agtttggacc gttcattgag       60

agcatttcag gtatcactga tcaatcgaat gacgtgtttg aagatgcagc aaaagcattc      120

tctatgttta ctcgcagcga tgtctacaag gcgctggatg aaataccttt ctctgatgat      180

gcgatgcttc caatccctcc aactatatat acgaaaccat ctcacgattc atattattac      240

attgatgctc taaaccgtgt gcgtcgcaaa acatatcagg gccctgatga cgtgtacgta      300

cctaattgtt ctattgttga attgctggag ccacatgaga ctctgacatc ttatgggcgg      360

ttgtccgagg ccatcgagaa tcgtgccaag gatggggaca gccaagccag aatcgccaca      420

acgtatggta gaatcgctga atctcaagct cgacagatta aggctccatt ggagaagttt      480

gtgttggcac tattagtggc cgaagcaggg gggtctttat atgatccagt tttgcagaag      540

tatgatgaga ttccagatct atcgcataat tgccctttat ggtgttttag agagatctgt      600

cgtcacatat ctggtccatt accagatcgg gcaccttatc tttacttatc tgcaggggta      660

ttctggttaa tgtcaccacg aatgacgtct gcaatccctc cgctactatc cgatcttgtt      720

aatttagcta ttttgcaaca aactgcgggt ttagatccat cattagtgaa attgggagta      780

cagatatgcc ttcatgcagc agctagctca agttattcat ggtttatctt aaagactaag      840

tctatttttc ctcaaaacac gttgcacagt atgtatgaat ctctagaagg gggatactgt      900

cctaatcttg aatggttaga gcctagatca gactataagt tcatgtacat gggagtcatg      960

ccattgtccg ctaagtatgc taggtcggcg ccgtccaatg ataagaaagc gcgggaactt     1020

ggcgagaaat atggactgag ctcagtcgtc ggtgagcttc gtaaacggac aaagacgtat     1080

gttaaacatg actttgcttc agtgaggtac attcgtgacg ctatggcatg tactagcggt     1140

attttcttgg taagaacacc caccgaaacg gtattgcaag aatatacgca gagtccggag     1200

attaaggttc ccattcccca gaaagactgg acaggcccaa taggtgaaat cagaattcta     1260

aaagatacaa caagttccat cgcgcgttac ttatatagaa catggtactt ggcagcggcg     1320

agaatggcgg ctcaaccacg tacgtgggat ccattgtttc aagcgattat gagatctcaa     1380

tacgtgacag ctaggggtgg atctggcgca gcactccgcg aatctttgta tgcaatcaat     1440

gtgtcgttac ctgatttcaa gggcttacca gtgaaggcag caactaagat attccaggcg     1500

gcacaattag cgaacttgcc gttctcccac acatcagtgg ctatactagc tgacacttca     1560

atgggattgc gaaatcaggt gcagaggcgg ccacgatcca ttatgccatt aaatgtgccc     1620

cagcagcagg tttcggcgcc ccatacattg acagcggatt acattaacta ccacatgaat     1680

ctatcaccca cgtctggtag tgcggtcatt gagaaggtga ttcctttagg tgtatacgct     1740

tcgagccctc ctaaccagtc gatcaacatt gacatatctg cgtgtgacgc tagtattact     1800

tgggatttct ttctgtcagt gattatggcg gctatacacg aaggtgtcgc tagtagctcc     1860

attggaaaac catttatggg ggttcctgca tccattgtaa atgatgagtc tgtcgttgga     1920

gtgagagctg ctaggccgat atcgggaatg cagaacatga ttcagcatct atcgaaacta     1980

tataaacgtg gattttcata tagagtaaac gattcttttt ctccaggtaa cgattttact     2040

catatgacta ccactttccc gtcaggttca acagccacct ctactgagca tactgctaat     2100

aatagtacga tgatggaaac tttcctgaca gtatggggac ccgaacatac tgacgaccct     2160

gacgtcttac gtttaatgaa gtctttaact attcaaagga attacgtatg tcaaggtgat     2220

gatggattaa tgattatcga tgggactact gctggtaagg tgaacagtga aactattcag     2280

aacgatctag aattaatctc aaaatatggt gaggaattcg gatggaaata tgacatagcg     2340

tacgatggga ctgccgaata cttaaagcta tacttcatat ttggctgtcg aattccaaat     2400

cttagtcgcc atccaatcgt ggggaaagaa cgggcgaatt cttcagcaga ggagccatgg     2460

ccagcaattc tagatcagat tatgggtgtc ttctttaatg gtgttcatga tgggttacag     2520

tggcagcggt ggatacgtta ttcatgggct ctatgctgtg ctttctcacg tcaaagaaca     2580

atgattggtg agagcgtggg ttaccttcaa tatcctatgt ggtcttttgt ctactgggga     2640

ttaccactgg ttaaagcgtt tgggtcagac ccatggatat tttcttggta catgcctact     2700

ggagatctgg gaatgtatag ttggattagc ttgatacgcc ctctgatgac aagatggatg     2760

gtggctaatg gttacgtaac tgacagatgc tcaaccgtat tcgggaacgc agattatcgc     2820

aggtgtttca atgaacttaa actatatcaa ggttattata tggcacaatt gcccaggaat     2880

cctaagaagt ctggacgagc ggcctctcgg gaggtaagag aacaattcac tcaggcatta     2940

tccgactatc taatgcaaaa tccagagctg aagtcacgtg tgctacgtgg tcgtagtgag     3000

tgggagaaat atggagcggg gataattcac aatcctccgt cattattcga tgtgccccat     3060

aaatggtatc agggtgcgca agaggcagca atcgctacga gagaagagct ggcagaaatg     3120

gatgagacat taatgcgcgc tcgaaggcac agctattcga gcttttcaaa gttattagag     3180

gcgtatctgc tcgtgaaatg gcgaatgtgc gaggcccgcg aaccgtcggt tgatttgcga     3240

ttaccattat gtgcgggtat tgacccatta aactcagatc cttttctcaa gatggtaagc     3300

gttggaccaa tgctccagag tacgagaaag tactttgctc agacactatt catggcaaag     3360

acggtgtcgg gtcttgacgt taacgcgatt gatagcgcgt tattacgact gcgaacatta     3420

ggtgctgata agaaagcatt aacggcgcag ttattaatgg tggggcttca ggagtcagaa     3480

gcggacgcat tggccgggaa gataatgcta caggatgtga atactgtgca attagccaga     3540

gtggttaact tagctgtgcc agatacttgg atgtcgttag actttgactc tatgttcaaa     3600

caccacgtca agctgcttcc caaagatgga cgtcatctaa atactgatat tcctcctcga     3660

atgggatggt tacgggccat tttacgattc ttaggtgccg gaatggtaat gactgcgact     3720

ggagttgctg tcgacatcta tctggaggat atacatggcg gtggtcggtc acttggacag     3780

agattcatga cttggatgcg acaggaagga cggtcagcgt gagtctacca tgggtcgtgg     3840

tgcgtcaact catc                                                       3854


<210>  23
<211>  1267
<212>  PRT
<213>  reovirus

<400>  23

Met Ser Ser Met Ile Leu Thr Gln Phe Gly Pro Phe Ile Glu Ser Ile 
1               5                   10                  15      


Ser Gly Ile Thr Asp Gln Ser Asn Asp Val Phe Glu Asp Ala Ala Lys 
            20                  25                  30          


Ala Phe Ser Met Phe Thr Arg Ser Asp Val Tyr Lys Ala Leu Asp Glu 
        35                  40                  45              


Ile Pro Phe Ser Asp Asp Ala Met Leu Pro Ile Pro Pro Thr Ile Tyr 
    50                  55                  60                  


Thr Lys Pro Ser His Asp Ser Tyr Tyr Tyr Ile Asp Ala Leu Asn Arg 
65                  70                  75                  80  


Val Arg Arg Lys Thr Tyr Gln Gly Pro Asp Asp Val Tyr Val Pro Asn 
                85                  90                  95      


Cys Ser Ile Val Glu Leu Leu Glu Pro His Glu Thr Leu Thr Ser Tyr 
            100                 105                 110         


Gly Arg Leu Ser Glu Ala Ile Glu Asn Arg Ala Lys Asp Gly Asp Ser 
        115                 120                 125             


Gln Ala Arg Ile Ala Thr Thr Tyr Gly Arg Ile Ala Glu Ser Gln Ala 
    130                 135                 140                 


Arg Gln Ile Lys Ala Pro Leu Glu Lys Phe Val Leu Ala Leu Leu Val 
145                 150                 155                 160 


Ala Glu Ala Gly Gly Ser Leu Tyr Asp Pro Val Leu Gln Lys Tyr Asp 
                165                 170                 175     


Glu Ile Pro Asp Leu Ser His Asn Cys Pro Leu Trp Cys Phe Arg Glu 
            180                 185                 190         


Ile Cys Arg His Ile Ser Gly Pro Leu Pro Asp Arg Ala Pro Tyr Leu 
        195                 200                 205             


Tyr Leu Ser Ala Gly Val Phe Trp Leu Met Ser Pro Arg Met Thr Ser 
    210                 215                 220                 


Ala Ile Pro Pro Leu Leu Ser Asp Leu Val Asn Leu Ala Ile Leu Gln 
225                 230                 235                 240 


Gln Thr Ala Gly Leu Asp Pro Ser Leu Val Lys Leu Gly Val Gln Ile 
                245                 250                 255     


Cys Leu His Ala Ala Ala Ser Ser Ser Tyr Ser Trp Phe Ile Leu Lys 
            260                 265                 270         


Thr Lys Ser Ile Phe Pro Gln Asn Thr Leu His Ser Met Tyr Glu Ser 
        275                 280                 285             


Leu Glu Gly Gly Tyr Cys Pro Asn Leu Glu Trp Leu Glu Pro Arg Ser 
    290                 295                 300                 


Asp Tyr Lys Phe Met Tyr Met Gly Val Met Pro Leu Ser Ala Lys Tyr 
305                 310                 315                 320 


Ala Arg Ser Ala Pro Ser Asn Asp Lys Lys Ala Arg Glu Leu Gly Glu 
                325                 330                 335     


Lys Tyr Gly Leu Ser Ser Val Val Gly Glu Leu Arg Lys Arg Thr Lys 
            340                 345                 350         


Thr Tyr Val Lys His Asp Phe Ala Ser Val Arg Tyr Ile Arg Asp Ala 
        355                 360                 365             


Met Ala Cys Thr Ser Gly Ile Phe Leu Val Arg Thr Pro Thr Glu Thr 
    370                 375                 380                 


Val Leu Gln Glu Tyr Thr Gln Ser Pro Glu Ile Lys Val Pro Ile Pro 
385                 390                 395                 400 


Gln Lys Asp Trp Thr Gly Pro Ile Gly Glu Ile Arg Ile Leu Lys Asp 
                405                 410                 415     


Thr Thr Ser Ser Ile Ala Arg Tyr Leu Tyr Arg Thr Trp Tyr Leu Ala 
            420                 425                 430         


Ala Ala Arg Met Ala Ala Gln Pro Arg Thr Trp Asp Pro Leu Phe Gln 
        435                 440                 445             


Ala Ile Met Arg Ser Gln Tyr Val Thr Ala Arg Gly Gly Ser Gly Ala 
    450                 455                 460                 


Ala Leu Arg Glu Ser Leu Tyr Ala Ile Asn Val Ser Leu Pro Asp Phe 
465                 470                 475                 480 


Lys Gly Leu Pro Val Lys Ala Ala Thr Lys Ile Phe Gln Ala Ala Gln 
                485                 490                 495     


Leu Ala Asn Leu Pro Phe Ser His Thr Ser Val Ala Ile Leu Ala Asp 
            500                 505                 510         


Thr Ser Met Gly Leu Arg Asn Gln Val Gln Arg Arg Pro Arg Ser Ile 
        515                 520                 525             


Met Pro Leu Asn Val Pro Gln Gln Gln Val Ser Ala Pro His Thr Leu 
    530                 535                 540                 


Thr Ala Asp Tyr Ile Asn Tyr His Met Asn Leu Ser Pro Thr Ser Gly 
545                 550                 555                 560 


Ser Ala Val Ile Glu Lys Val Ile Pro Leu Gly Val Tyr Ala Ser Ser 
                565                 570                 575     


Pro Pro Asn Gln Ser Ile Asn Ile Asp Ile Ser Ala Cys Asp Ala Ser 
            580                 585                 590         


Ile Thr Trp Asp Phe Phe Leu Ser Val Ile Met Ala Ala Ile His Glu 
        595                 600                 605             


Gly Val Ala Ser Ser Ser Ile Gly Lys Pro Phe Met Gly Val Pro Ala 
    610                 615                 620                 


Ser Ile Val Asn Asp Glu Ser Val Val Gly Val Arg Ala Ala Arg Pro 
625                 630                 635                 640 


Ile Ser Gly Met Gln Asn Met Ile Gln His Leu Ser Lys Leu Tyr Lys 
                645                 650                 655     


Arg Gly Phe Ser Tyr Arg Val Asn Asp Ser Phe Ser Pro Gly Asn Asp 
            660                 665                 670         


Phe Thr His Met Thr Thr Thr Phe Pro Ser Gly Ser Thr Ala Thr Ser 
        675                 680                 685             


Thr Glu His Thr Ala Asn Asn Ser Thr Met Met Glu Thr Phe Leu Thr 
    690                 695                 700                 


Val Trp Gly Pro Glu His Thr Asp Asp Pro Asp Val Leu Arg Leu Met 
705                 710                 715                 720 


Lys Ser Leu Thr Ile Gln Arg Asn Tyr Val Cys Gln Gly Asp Asp Gly 
                725                 730                 735     


Leu Met Ile Ile Asp Gly Thr Thr Ala Gly Lys Val Asn Ser Glu Thr 
            740                 745                 750         


Ile Gln Asn Asp Leu Glu Leu Ile Ser Lys Tyr Gly Glu Glu Phe Gly 
        755                 760                 765             


Trp Lys Tyr Asp Ile Ala Tyr Asp Gly Thr Ala Glu Tyr Leu Lys Leu 
    770                 775                 780                 


Tyr Phe Ile Phe Gly Cys Arg Ile Pro Asn Leu Ser Arg His Pro Ile 
785                 790                 795                 800 


Val Gly Lys Glu Arg Ala Asn Ser Ser Ala Glu Glu Pro Trp Pro Ala 
                805                 810                 815     


Ile Leu Asp Gln Ile Met Gly Val Phe Phe Asn Gly Val His Asp Gly 
            820                 825                 830         


Leu Gln Trp Gln Arg Trp Ile Arg Tyr Ser Trp Ala Leu Cys Cys Ala 
        835                 840                 845             


Phe Ser Arg Gln Arg Thr Met Ile Gly Glu Ser Val Gly Tyr Leu Gln 
    850                 855                 860                 


Tyr Pro Met Trp Ser Phe Val Tyr Trp Gly Leu Pro Leu Val Lys Ala 
865                 870                 875                 880 


Phe Gly Ser Asp Pro Trp Ile Phe Ser Trp Tyr Met Pro Thr Gly Asp 
                885                 890                 895     


Leu Gly Met Tyr Ser Trp Ile Ser Leu Ile Arg Pro Leu Met Thr Arg 
            900                 905                 910         


Trp Met Val Ala Asn Gly Tyr Val Thr Asp Arg Cys Ser Thr Val Phe 
        915                 920                 925             


Gly Asn Ala Asp Tyr Arg Arg Cys Phe Asn Glu Leu Lys Leu Tyr Gln 
    930                 935                 940                 


Gly Tyr Tyr Met Ala Gln Leu Pro Arg Asn Pro Lys Lys Ser Gly Arg 
945                 950                 955                 960 


Ala Ala Ser Arg Glu Val Arg Glu Gln Phe Thr Gln Ala Leu Ser Asp 
                965                 970                 975     


Tyr Leu Met Gln Asn Pro Glu Leu Lys Ser Arg Val Leu Arg Gly Arg 
            980                 985                 990         


Ser Glu Trp Glu Lys Tyr Gly Ala  Gly Ile Ile His Asn  Pro Pro Ser 
        995                 1000                 1005             


Leu Phe  Asp Val Pro His Lys  Trp Tyr Gln Gly Ala  Gln Glu Ala 
    1010                 1015                 1020             


Ala Ile  Ala Thr Arg Glu Glu  Leu Ala Glu Met Asp  Glu Thr Leu 
    1025                 1030                 1035             


Met Arg  Ala Arg Arg His Ser  Tyr Ser Ser Phe Ser  Lys Leu Leu 
    1040                 1045                 1050             


Glu Ala  Tyr Leu Leu Val Lys  Trp Arg Met Cys Glu  Ala Arg Glu 
    1055                 1060                 1065             


Pro Ser  Val Asp Leu Arg Leu  Pro Leu Cys Ala Gly  Ile Asp Pro 
    1070                 1075                 1080             


Leu Asn  Ser Asp Pro Phe Leu  Lys Met Val Ser Val  Gly Pro Met 
    1085                 1090                 1095             


Leu Gln  Ser Thr Arg Lys Tyr  Phe Ala Gln Thr Leu  Phe Met Ala 
    1100                 1105                 1110             


Lys Thr  Val Ser Gly Leu Asp  Val Asn Ala Ile Asp  Ser Ala Leu 
    1115                 1120                 1125             


Leu Arg  Leu Arg Thr Leu Gly  Ala Asp Lys Lys Ala  Leu Thr Ala 
    1130                 1135                 1140             


Gln Leu  Leu Met Val Gly Leu  Gln Glu Ser Glu Ala  Asp Ala Leu 
    1145                 1150                 1155             


Ala Gly  Lys Ile Met Leu Gln  Asp Val Asn Thr Val  Gln Leu Ala 
    1160                 1165                 1170             


Arg Val  Val Asn Leu Ala Val  Pro Asp Thr Trp Met  Ser Leu Asp 
    1175                 1180                 1185             


Phe Asp  Ser Met Phe Lys His  His Val Lys Leu Leu  Pro Lys Asp 
    1190                 1195                 1200             


Gly Arg  His Leu Asn Thr Asp  Ile Pro Pro Arg Met  Gly Trp Leu 
    1205                 1210                 1215             


Arg Ala  Ile Leu Arg Phe Leu  Gly Ala Gly Met Val  Met Thr Ala 
    1220                 1225                 1230             


Thr Gly  Val Ala Val Asp Ile  Tyr Leu Glu Asp Ile  His Gly Gly 
    1235                 1240                 1245             


Gly Arg  Ser Leu Gly Gln Arg  Phe Met Thr Trp Met  Arg Gln Glu 
    1250                 1255                 1260             


Gly Arg  Ser Ala 
    1265         


<210>  24
<211>  1196
<212>  DNA
<213>  reovirus

<400>  24
gctatttttg cctcttccca gacgttgtcg caatggaggt gtgcttgccc aacggtcatc       60

aggtcgtgga cttgattaac aacgcttttg aaggtcgtgt atcaatctac agcgcgcaag      120

agggatggga caaaacaatc tcagcacagc cagatatgat ggtatgtggt ggcgccgtcg      180

tttgcatgca ttgtctaggt gttgttggat ctctacaacg caagctgaag catttgcctc      240

accatagatg taatcaacag atccgtcatc aggattacgt cgatgtacag ttcgcagacc      300

gtgttactgc tcactggaag cggggtatgc tgtccttcgt tgcgcagatg cacgagatga      360

tgaatgacgt gtcgccagat gacctggatc gtgtgcgtac tgagggaggt tcactagtgg      420

agctgaaccg gcttcaggtt gacccaaatt caatgtttag atcaatacac tcaagttgga      480

cagatccttt gcaggtggtg gacgaccttg acactaagct ggatcagtac tggacagcct      540

taaacctgat gatcgactca tccgacttga tacccaactt tatgatgaga gacccatcac      600

acgcgttcaa tggtgtgaaa ctggagggag atgctcgtca aacccaattc tccaggactt      660

ttgattcgag atcgagtttg gaatggggtg tgatggttta tgattactct gagctggagc      720

atgatccatc gaagggccgt gcttacagaa aggaattggt gacgccagct cgagatttcg      780

gtcactttgg attatcccat tattctaggg cgactacccc aatccttgga aagatgccgg      840

ccgtattctc aggaatgttg actgggaact gtaaaatgta tccattcatt aaaggaacgg      900

ctaagctgaa gacagtgcgc aagctagtgg aggcagtcaa tcatgcttgg ggtgtcgaga      960

agattagata tgctcttggg ccaggtggca tgacgggatg gtacaatagg actatgcaac     1020

aggcccccat tgtgctaact cctgctgctc tcacaatgtt cccagatacc atcaagtttg     1080

gggatttgaa ttatccagtg atgattggcg atccgatgat tcttggctaa acacccccat     1140

cttcacagcg ccgggcttga ccaacctggt gtgacgtggg acaggcttca ttcatc         1196


<210>  25
<211>  365
<212>  PRT
<213>  reovirus

<400>  25

Met Glu Val Cys Leu Pro Asn Gly His Gln Val Val Asp Leu Ile Asn 
1               5                   10                  15      


Asn Ala Phe Glu Gly Arg Val Ser Ile Tyr Ser Ala Gln Glu Gly Trp 
            20                  25                  30          


Asp Lys Thr Ile Ser Ala Gln Pro Asp Met Met Val Cys Gly Gly Ala 
        35                  40                  45              


Val Val Cys Met His Cys Leu Gly Val Val Gly Ser Leu Gln Arg Lys 
    50                  55                  60                  


Leu Lys His Leu Pro His His Arg Cys Asn Gln Gln Ile Arg His Gln 
65                  70                  75                  80  


Asp Tyr Val Asp Val Gln Phe Ala Asp Arg Val Thr Ala His Trp Lys 
                85                  90                  95      


Arg Gly Met Leu Ser Phe Val Ala Gln Met His Glu Met Met Asn Asp 
            100                 105                 110         


Val Ser Pro Asp Asp Leu Asp Arg Val Arg Thr Glu Gly Gly Ser Leu 
        115                 120                 125             


Val Glu Leu Asn Arg Leu Gln Val Asp Pro Asn Ser Met Phe Arg Ser 
    130                 135                 140                 


Ile His Ser Ser Trp Thr Asp Pro Leu Gln Val Val Asp Asp Leu Asp 
145                 150                 155                 160 


Thr Lys Leu Asp Gln Tyr Trp Thr Ala Leu Asn Leu Met Ile Asp Ser 
                165                 170                 175     


Ser Asp Leu Ile Pro Asn Phe Met Met Arg Asp Pro Ser His Ala Phe 
            180                 185                 190         


Asn Gly Val Lys Leu Glu Gly Asp Ala Arg Gln Thr Gln Phe Ser Arg 
        195                 200                 205             


Thr Phe Asp Ser Arg Ser Ser Leu Glu Trp Gly Val Met Val Tyr Asp 
    210                 215                 220                 


Tyr Ser Glu Leu Glu His Asp Pro Ser Lys Gly Arg Ala Tyr Arg Lys 
225                 230                 235                 240 


Glu Leu Val Thr Pro Ala Arg Asp Phe Gly His Phe Gly Leu Ser His 
                245                 250                 255     


Tyr Ser Arg Ala Thr Thr Pro Ile Leu Gly Lys Met Pro Ala Val Phe 
            260                 265                 270         


Ser Gly Met Leu Thr Gly Asn Cys Lys Met Tyr Pro Phe Ile Lys Gly 
        275                 280                 285             


Thr Ala Lys Leu Lys Thr Val Arg Lys Leu Val Glu Ala Val Asn His 
    290                 295                 300                 


Ala Trp Gly Val Glu Lys Ile Arg Tyr Ala Leu Gly Pro Gly Gly Met 
305                 310                 315                 320 


Thr Gly Trp Tyr Asn Arg Thr Met Gln Gln Ala Pro Ile Val Leu Thr 
                325                 330                 335     


Pro Ala Ala Leu Thr Met Phe Pro Asp Thr Ile Lys Phe Gly Asp Leu 
            340                 345                 350         


Asn Tyr Pro Val Met Ile Gly Asp Pro Met Ile Leu Gly 
        355                 360                 365 


<210>  26
<211>  2203
<212>  DNA
<213>  reovirus

<400>  26
gctaatctgc tgaccgttac tctgcaaaga tggggaacgc ttcctctatc gttcagacga       60

tcaacgtcac tggagatggc aatgtattta aaccatcagc tgaaacttca tctaccgctg      120

taccatcgtt aagcttatca cctggaatgc tgaatcccgg aggggtacca tggattgctg      180

ttggagatga gacatctgtg acttcaccag gcgcattacg tcgaatgacg tcaaaggaca      240

tcccggaaac ggcaataatc aacacagaca attcatcagg cgccgtgcca agcgaatcag      300

cgcttgtgcc ctacatcgat gagccgctgg tagtggttac agagcatgct attaccaact      360

tcaccaaagc tgagatggca cttgaattca atcgtgagtt ccttgacaag atgcgtgtgc      420

tgtcagtgtc accaaaatat tcggatcttc tgacctatgt tgactgctac gtcggtgtgt      480

ctgctcgtca ggctttaaac aattttcaga aacaagtgcc tgtgattaca cctactaggc      540

agacgatgta tgtcgactcg atacaagcgg ccttgaaagc tttagaaaag tgggagattg      600

atctgagagt ggctcaaacg ttgctgccta cgaacgttcc gattggagaa gtctcttgtc      660

caatgcagtc ggtagtgaaa ctgctggatg atcagctgcc agatgacacg ctgatacgga      720

ggtatcccaa ggaagccgcc gtcgctttgg ctaaacgaaa cgggggaata caatggatgg      780

acgtatcaga aggcaccgtg atgaacgagg ctgtcaacgc tgttgcagct agtgcactgg      840

caccttcagc atcagcccca cccttagaag agaagtcaaa gttaaccgaa caagcgatgg      900

atctcgtgac cgcggctgag cctgagataa ttgcctcact cgcgccagtt cccgcacccg      960

tgtttgccat accacctaaa ccagcagatt ataatgtgcg tactctgagg atcgacgagg     1020

ccacttggct gcgaatgatt ccaaaatcaa tgaacacacc ttttcaaatc caggtgactg     1080

ataacacagg aactaattgg catctcaatt tgaggggggg gactcgtgta gtgaatctgg     1140

accaaatcgc tccgatgcgg tttgtattag atttaggggg aaagagttat aaagagacga     1200

gctgggatcc aaacggcaag aaggtcggat tcatcgtttt tcaatcgaag ataccattcg     1260

aactttggac tgctgcttca cagatcggtc aagccacggt ggttaactat gtccaactat     1320

acgctgaaga cagctcattt accgcgcagt ctatcattgc tactacctct ttggcttata     1380

actatgagcc tgagcagttg aataagactg accctgagat gaattattat cttttggcga     1440

cctttataga ctcagccgct ataacgccaa cgaatatgac acagcctgat gtttgggatg     1500

ccttgctgac gatgtcccca ctatcagctg gcgaggtgac agtgaagggt gcggtagtga     1560

gtgaagtagt ccctgcagac ttgataggta gctacactcc agaatcccta aacgcctcac     1620

ttccgaatga tgctgctaga tgcatgatcg atagagcttc gaagatagcc gaagcaatca     1680

agattgatga tgatgctgga ccagatgaat attccccaaa ctctgtacca attcaaggtc     1740

agcttgctat ctcgcaactc gaaactggat atggtgtgcg aatattcaac cctaaaggga     1800

tcctttctaa aattgcatct agggcaatgc aggctttcat tggtgacccg agcacaatca     1860

tcacgcaggc ggcgccagtg ttatcagaca agaataattg gattgcattg gcacagggag     1920

tgaaaactag tctgcgtact aaaagtctat cagcgggagt gaagactgca gtgagtaagc     1980

tgagctcatc tgagtctatc cagaattgga ctcaaggatt cttggataaa gtgtcagcgc     2040

attttccagc accaaagccc gattgtccga ctagcggaga tagtggtgaa tcgtctaatc     2100

gccgagtgaa gcgcgactca tacgcaggag tggtcaaacg tgggtacaca cgttaggccg     2160

ctcgccctgg tgacgcgggg ttaagggatg caggcaaatc atc                       2203


<210>  27
<211>  708
<212>  PRT
<213>  reovirus

<400>  27

Met Gly Asn Ala Ser Ser Ile Val Gln Thr Ile Asn Val Thr Gly Asp 
1               5                   10                  15      


Gly Asn Val Phe Lys Pro Ser Ala Glu Thr Ser Ser Thr Ala Val Pro 
            20                  25                  30          


Ser Leu Ser Leu Ser Pro Gly Met Leu Asn Pro Gly Gly Val Pro Trp 
        35                  40                  45              


Ile Ala Val Gly Asp Glu Thr Ser Val Thr Ser Pro Gly Ala Leu Arg 
    50                  55                  60                  


Arg Met Thr Ser Lys Asp Ile Pro Glu Thr Ala Ile Ile Asn Thr Asp 
65                  70                  75                  80  


Asn Ser Ser Gly Ala Val Pro Ser Glu Ser Ala Leu Val Pro Tyr Ile 
                85                  90                  95      


Asp Glu Pro Leu Val Val Val Thr Glu His Ala Ile Thr Asn Phe Thr 
            100                 105                 110         


Lys Ala Glu Met Ala Leu Glu Phe Asn Arg Glu Phe Leu Asp Lys Met 
        115                 120                 125             


Arg Val Leu Ser Val Ser Pro Lys Tyr Ser Asp Leu Leu Thr Tyr Val 
    130                 135                 140                 


Asp Cys Tyr Val Gly Val Ser Ala Arg Gln Ala Leu Asn Asn Phe Gln 
145                 150                 155                 160 


Lys Gln Val Pro Val Ile Thr Pro Thr Arg Gln Thr Met Tyr Val Asp 
                165                 170                 175     


Ser Ile Gln Ala Ala Leu Lys Ala Leu Glu Lys Trp Glu Ile Asp Leu 
            180                 185                 190         


Arg Val Ala Gln Thr Leu Leu Pro Thr Asn Val Pro Ile Gly Glu Val 
        195                 200                 205             


Ser Cys Pro Met Gln Ser Val Val Lys Leu Leu Asp Asp Gln Leu Pro 
    210                 215                 220                 


Asp Asp Thr Leu Ile Arg Arg Tyr Pro Lys Glu Ala Ala Val Ala Leu 
225                 230                 235                 240 


Ala Lys Arg Asn Gly Gly Ile Gln Trp Met Asp Val Ser Glu Gly Thr 
                245                 250                 255     


Val Met Asn Glu Ala Val Asn Ala Val Ala Ala Ser Ala Leu Ala Pro 
            260                 265                 270         


Ser Ala Ser Ala Pro Pro Leu Glu Glu Lys Ser Lys Leu Thr Glu Gln 
        275                 280                 285             


Ala Met Asp Leu Val Thr Ala Ala Glu Pro Glu Ile Ile Ala Ser Leu 
    290                 295                 300                 


Ala Pro Val Pro Ala Pro Val Phe Ala Ile Pro Pro Lys Pro Ala Asp 
305                 310                 315                 320 


Tyr Asn Val Arg Thr Leu Arg Ile Asp Glu Ala Thr Trp Leu Arg Met 
                325                 330                 335     


Ile Pro Lys Ser Met Asn Thr Pro Phe Gln Ile Gln Val Thr Asp Asn 
            340                 345                 350         


Thr Gly Thr Asn Trp His Leu Asn Leu Arg Gly Gly Thr Arg Val Val 
        355                 360                 365             


Asn Leu Asp Gln Ile Ala Pro Met Arg Phe Val Leu Asp Leu Gly Gly 
    370                 375                 380                 


Lys Ser Tyr Lys Glu Thr Ser Trp Asp Pro Asn Gly Lys Lys Val Gly 
385                 390                 395                 400 


Phe Ile Val Phe Gln Ser Lys Ile Pro Phe Glu Leu Trp Thr Ala Ala 
                405                 410                 415     


Ser Gln Ile Gly Gln Ala Thr Val Val Asn Tyr Val Gln Leu Tyr Ala 
            420                 425                 430         


Glu Asp Ser Ser Phe Thr Ala Gln Ser Ile Ile Ala Thr Thr Ser Leu 
        435                 440                 445             


Ala Tyr Asn Tyr Glu Pro Glu Gln Leu Asn Lys Thr Asp Pro Glu Met 
    450                 455                 460                 


Asn Tyr Tyr Leu Leu Ala Thr Phe Ile Asp Ser Ala Ala Ile Thr Pro 
465                 470                 475                 480 


Thr Asn Met Thr Gln Pro Asp Val Trp Asp Ala Leu Leu Thr Met Ser 
                485                 490                 495     


Pro Leu Ser Ala Gly Glu Val Thr Val Lys Gly Ala Val Val Ser Glu 
            500                 505                 510         


Val Val Pro Ala Asp Leu Ile Gly Ser Tyr Thr Pro Glu Ser Leu Asn 
        515                 520                 525             


Ala Ser Leu Pro Asn Asp Ala Ala Arg Cys Met Ile Asp Arg Ala Ser 
    530                 535                 540                 


Lys Ile Ala Glu Ala Ile Lys Ile Asp Asp Asp Ala Gly Pro Asp Glu 
545                 550                 555                 560 


Tyr Ser Pro Asn Ser Val Pro Ile Gln Gly Gln Leu Ala Ile Ser Gln 
                565                 570                 575     


Leu Glu Thr Gly Tyr Gly Val Arg Ile Phe Asn Pro Lys Gly Ile Leu 
            580                 585                 590         


Ser Lys Ile Ala Ser Arg Ala Met Gln Ala Phe Ile Gly Asp Pro Ser 
        595                 600                 605             


Thr Ile Ile Thr Gln Ala Ala Pro Val Leu Ser Asp Lys Asn Asn Trp 
    610                 615                 620                 


Ile Ala Leu Ala Gln Gly Val Lys Thr Ser Leu Arg Thr Lys Ser Leu 
625                 630                 635                 640 


Ser Ala Gly Val Lys Thr Ala Val Ser Lys Leu Ser Ser Ser Glu Ser 
                645                 650                 655     


Ile Gln Asn Trp Thr Gln Gly Phe Leu Asp Lys Val Ser Ala His Phe 
            660                 665                 670         


Pro Ala Pro Lys Pro Asp Cys Pro Thr Ser Gly Asp Ser Gly Glu Ser 
        675                 680                 685             


Ser Asn Arg Arg Val Lys Arg Asp Ser Tyr Ala Gly Val Val Lys Arg 
    690                 695                 700                 


Gly Tyr Thr Arg 
705             


<210>  28
<211>  2304
<212>  DNA
<213>  reovirus

<400>  28
gctattcgcg gtcatggctt acatcgcagt tcctgcggtg gtggattcac gttcgagtga       60

ggctattgga ctgctagaat cgtttggagt agacgctggg gctgacgcga atgacgtttc      120

atatcaagat catgactatg tgttggatca gttacagtac atgttagatg gatatgaggc      180

tggtgacgtt atcgatgcac tcgtccacaa gaattggtta catcactctg tctattgctt      240

gttgccaccc aaaagtcaac tattagagta ttggaaaagt aatccttcag cgataccgga      300

caacgttgat cgtcggcttc gtaaacgact aatgctaaag aaagatctca ggaaagatga      360

tgaatacaat cagctagcgc gtgctttcaa gatatcggat gtctacgcac ctctcatctc      420

atccacgacg tcaccgatga caatgataca gaacttgaat cgaggcgaga tcgtgtacac      480

cacgacggac agggtaatag gggctagaat cttgttatat gctcctagaa agtactatgc      540

gtcaactctg tcatttacta tgactaagtg catcattccg tttggtaaag aggtgggtcg      600

tgttcctcac tctcgattta atgttggcac atttccgtca attgctaccc cgaaatgttt      660

tgtcatgagt ggggttgata ttgagtccat cccaaatgaa tttatcaagt tgttttacca      720

gcgcgtcaag agtgttcacg ctaacatact aaatgacata tctcctcaga tcgtctctga      780

catgataaac agaaagcgtc tgcgcgttca tactccatca gatcgtcgag ccgcgcagtt      840

gatgcatttg ccttaccatg ttaaacgagg agcgtctcac gtcgacgttt acaaggtgga      900

tgttgtagac atgttgttcg aggtagtgga tgtggccgat gggttgcgca acgtatctag      960

gaaactaact atgcataccg ttcctgtatg tattcttgaa atgttgggta ttgagattgc     1020

ggactattgc attcgtcaag aggatggaat gctcacagat tggttcctac ttttaaccat     1080

gctatctgat ggcttgactg atagaaggac gcattgtcaa tacttgatga atccgtcaag     1140

tgtgcctcct gatgtgatac ttaacatctc aattactgga tttataaata gacatacaat     1200

cgatgtcatg cctgacatat atgacttcgt taaacccatt ggcgctgtgc tgcctaaggg     1260

atcatttaaa tcaacaatta tgagagttct tgattcaata tcaatattag gaatccaaat     1320

catgccgcgc gcgcatgtag ttgactcaga tgaggtgggc gagcaaatgg agcctacgtt     1380

tgagcaggcg gttatggaga tatacaaagg gattgctggc gttgactcgc tggatgatct     1440

catcaagtgg gtgttgaact cggatctcat tccgcatgat gacaggcttg gtcaattatt     1500

tcaagcgttt ttgcctctcg caaaggactt attagctcca atggccagaa agttttatga     1560

taactcaatg agtgagggta gattgctaac attcgctcat gccgacagtg agttgctgaa     1620

cgcaaattat tttggtcatt tattgcgact aaaaatacca tatattacag aggttaatct     1680

gatgattcgc aagaatcgtg agggtggaga gctatttcag cttgtgttat cttatctata     1740

taaaatgtat gctactagcg cgcagcctaa atggtttgga tcattattgc gattgttaat     1800

atgtccctgg ttacatatgg agaaattaat aggagaagca gacccggcat ctacgtcggc     1860

tgaaattggg tggcatatcc ctcgtgaaca gctgatgcaa gatggatggt gtggatgtga     1920

agacggattc attccctatg ttagcatacg tgcgccaaga ctggttatag aggagttgat     1980

ggagaagaac tggggccaat atcatgccca agttattgtc actgatcagc ttgtcgtagg     2040

cgaaccgcgg agggtatctg ctaaggctgt gatcaagggt aaccacttac cagttaagtt     2100

agtttcacga tttgcatgtt tcacattgac ggcgaagtat gagatgaggc tttcgtgcgg     2160

ccatagcact ggacgtggag ctgcatacag tgcgagacta gctttccgat ctgacttggc     2220

gtgatccgtg acatgcgtag tgtgacacct gctcctaggt caatgggggt agggggcggg     2280

ctaagactac gtacgcgctt catc                                            2304


<210>  29
<211>  736
<212>  PRT
<213>  reovirus

<400>  29

Met Ala Tyr Ile Ala Val Pro Ala Val Val Asp Ser Arg Ser Ser Glu 
1               5                   10                  15      


Ala Ile Gly Leu Leu Glu Ser Phe Gly Val Asp Ala Gly Ala Asp Ala 
            20                  25                  30          


Asn Asp Val Ser Tyr Gln Asp His Asp Tyr Val Leu Asp Gln Leu Gln 
        35                  40                  45              


Tyr Met Leu Asp Gly Tyr Glu Ala Gly Asp Val Ile Asp Ala Leu Val 
    50                  55                  60                  


His Lys Asn Trp Leu His His Ser Val Tyr Cys Leu Leu Pro Pro Lys 
65                  70                  75                  80  


Ser Gln Leu Leu Glu Tyr Trp Lys Ser Asn Pro Ser Ala Ile Pro Asp 
                85                  90                  95      


Asn Val Asp Arg Arg Leu Arg Lys Arg Leu Met Leu Lys Lys Asp Leu 
            100                 105                 110         


Arg Lys Asp Asp Glu Tyr Asn Gln Leu Ala Arg Ala Phe Lys Ile Ser 
        115                 120                 125             


Asp Val Tyr Ala Pro Leu Ile Ser Ser Thr Thr Ser Pro Met Thr Met 
    130                 135                 140                 


Ile Gln Asn Leu Asn Arg Gly Glu Ile Val Tyr Thr Thr Thr Asp Arg 
145                 150                 155                 160 


Val Ile Gly Ala Arg Ile Leu Leu Tyr Ala Pro Arg Lys Tyr Tyr Ala 
                165                 170                 175     


Ser Thr Leu Ser Phe Thr Met Thr Lys Cys Ile Ile Pro Phe Gly Lys 
            180                 185                 190         


Glu Val Gly Arg Val Pro His Ser Arg Phe Asn Val Gly Thr Phe Pro 
        195                 200                 205             


Ser Ile Ala Thr Pro Lys Cys Phe Val Met Ser Gly Val Asp Ile Glu 
    210                 215                 220                 


Ser Ile Pro Asn Glu Phe Ile Lys Leu Phe Tyr Gln Arg Val Lys Ser 
225                 230                 235                 240 


Val His Ala Asn Ile Leu Asn Asp Ile Ser Pro Gln Ile Val Ser Asp 
                245                 250                 255     


Met Ile Asn Arg Lys Arg Leu Arg Val His Thr Pro Ser Asp Arg Arg 
            260                 265                 270         


Ala Ala Gln Leu Met His Leu Pro Tyr His Val Lys Arg Gly Ala Ser 
        275                 280                 285             


His Val Asp Val Tyr Lys Val Asp Val Val Asp Met Leu Phe Glu Val 
    290                 295                 300                 


Val Asp Val Ala Asp Gly Leu Arg Asn Val Ser Arg Lys Leu Thr Met 
305                 310                 315                 320 


His Thr Val Pro Val Cys Ile Leu Glu Met Leu Gly Ile Glu Ile Ala 
                325                 330                 335     


Asp Tyr Cys Ile Arg Gln Glu Asp Gly Met Leu Thr Asp Trp Phe Leu 
            340                 345                 350         


Leu Leu Thr Met Leu Ser Asp Gly Leu Thr Asp Arg Arg Thr His Cys 
        355                 360                 365             


Gln Tyr Leu Met Asn Pro Ser Ser Val Pro Pro Asp Val Ile Leu Asn 
    370                 375                 380                 


Ile Ser Ile Thr Gly Phe Ile Asn Arg His Thr Ile Asp Val Met Pro 
385                 390                 395                 400 


Asp Ile Tyr Asp Phe Val Lys Pro Ile Gly Ala Val Leu Pro Lys Gly 
                405                 410                 415     


Ser Phe Lys Ser Thr Ile Met Arg Val Leu Asp Ser Ile Ser Ile Leu 
            420                 425                 430         


Gly Ile Gln Ile Met Pro Arg Ala His Val Val Asp Ser Asp Glu Val 
        435                 440                 445             


Gly Glu Gln Met Glu Pro Thr Phe Glu Gln Ala Val Met Glu Ile Tyr 
    450                 455                 460                 


Lys Gly Ile Ala Gly Val Asp Ser Leu Asp Asp Leu Ile Lys Trp Val 
465                 470                 475                 480 


Leu Asn Ser Asp Leu Ile Pro His Asp Asp Arg Leu Gly Gln Leu Phe 
                485                 490                 495     


Gln Ala Phe Leu Pro Leu Ala Lys Asp Leu Leu Ala Pro Met Ala Arg 
            500                 505                 510         


Lys Phe Tyr Asp Asn Ser Met Ser Glu Gly Arg Leu Leu Thr Phe Ala 
        515                 520                 525             


His Ala Asp Ser Glu Leu Leu Asn Ala Asn Tyr Phe Gly His Leu Leu 
    530                 535                 540                 


Arg Leu Lys Ile Pro Tyr Ile Thr Glu Val Asn Leu Met Ile Arg Lys 
545                 550                 555                 560 


Asn Arg Glu Gly Gly Glu Leu Phe Gln Leu Val Leu Ser Tyr Leu Tyr 
                565                 570                 575     


Lys Met Tyr Ala Thr Ser Ala Gln Pro Lys Trp Phe Gly Ser Leu Leu 
            580                 585                 590         


Arg Leu Leu Ile Cys Pro Trp Leu His Met Glu Lys Leu Ile Gly Glu 
        595                 600                 605             


Ala Asp Pro Ala Ser Thr Ser Ala Glu Ile Gly Trp His Ile Pro Arg 
    610                 615                 620                 


Glu Gln Leu Met Gln Asp Gly Trp Cys Gly Cys Glu Asp Gly Phe Ile 
625                 630                 635                 640 


Pro Tyr Val Ser Ile Arg Ala Pro Arg Leu Val Ile Glu Glu Leu Met 
                645                 650                 655     


Glu Lys Asn Trp Gly Gln Tyr His Ala Gln Val Ile Val Thr Asp Gln 
            660                 665                 670         


Leu Val Val Gly Glu Pro Arg Arg Val Ser Ala Lys Ala Val Ile Lys 
        675                 680                 685             


Gly Asn His Leu Pro Val Lys Leu Val Ser Arg Phe Ala Cys Phe Thr 
    690                 695                 700                 


Leu Thr Ala Lys Tyr Glu Met Arg Leu Ser Cys Gly His Ser Thr Gly 
705                 710                 715                 720 


Arg Gly Ala Ala Tyr Ser Ala Arg Leu Ala Phe Arg Ser Asp Leu Ala 
                725                 730                 735     


<210>  30
<211>  418
<212>  PRT
<213>  reovirus

<400>  30

Met Ala Arg Ala Ala Phe Leu Phe Lys Thr Val Gly Phe Gly Gly Leu 
1               5                   10                  15      


Gln Asn Val Pro Ile Asn Asp Glu Leu Ser Ser His Leu Leu Arg Ala 
            20                  25                  30          


Gly Asn Ser Pro Trp Gln Leu Thr Gln Phe Leu Asp Trp Ile Ser Leu 
        35                  40                  45              


Gly Arg Gly Leu Ala Thr Ser Ala Leu Val Pro Thr Ala Gly Ser Arg 
    50                  55                  60                  


Tyr Tyr Gln Met Ser Cys Leu Leu Ser Gly Thr Leu Gln Ile Pro Phe 
65                  70                  75                  80  


Arg Pro Asn His Arg Trp Gly Asp Ile Arg Phe Leu Arg Leu Val Trp 
                85                  90                  95      


Ser Ala Pro Thr Leu Asp Gly Leu Val Val Ala Pro Pro Gln Val Leu 
            100                 105                 110         


Ala Gln Pro Ala Leu Gln Ala Gln Ala Asp Arg Val Tyr Asp Cys Asp 
        115                 120                 125             


Asp Tyr Pro Phe Leu Ala Arg Asp Pro Arg Phe Lys His Arg Val Tyr 
    130                 135                 140                 


Gln Gln Leu Ser Ala Val Thr Leu Leu Asn Leu Thr Gly Phe Gly Pro 
145                 150                 155                 160 


Ile Ser Tyr Val Arg Val Asp Glu Asp Met Trp Ser Gly Asp Val Asn 
                165                 170                 175     


Gln Leu Leu Met Asn Tyr Phe Gly His Thr Phe Ala Glu Ile Ala Tyr 
            180                 185                 190         


Thr Leu Cys Gln Ala Ser Ala Asn Arg Pro Trp Glu Tyr Asp Gly Thr 
        195                 200                 205             


Tyr Ala Arg Met Thr Gln Ile Val Leu Ser Leu Phe Trp Leu Ser Tyr 
    210                 215                 220                 


Val Gly Val Ile His Gln Gln Asn Thr Tyr Arg Thr Phe Tyr Phe Gln 
225                 230                 235                 240 


Cys Asn Arg Arg Gly Asp Ala Ala Glu Val Trp Ile Leu Ser Cys Ser 
                245                 250                 255     


Leu Asn His Ser Ala Gln Ile Arg Pro Gly Asn Arg Ser Leu Phe Val 
            260                 265                 270         


Met Pro Thr Ser Pro Asp Trp Asn Met Asp Val Asn Leu Ile Leu Ser 
        275                 280                 285             


Ser Thr Leu Thr Gly Cys Leu Cys Ser Gly Ser Gln Leu Pro Leu Ile 
    290                 295                 300                 


Asp Asn Asn Ser Val Pro Ala Val Ser Arg Asn Ile His Gly Trp Thr 
305                 310                 315                 320 


Gly Arg Ala Gly Asn Gln Leu His Gly Phe Gln Val Arg Arg Met Val 
                325                 330                 335     


Thr Glu Phe Cys Asp Arg Leu Arg Arg Asp Gly Val Met Thr Gln Ala 
            340                 345                 350         


Gln Gln Asn Gln Val Glu Ala Leu Ala Asp Gln Thr Gln Gln Phe Lys 
        355                 360                 365             


Arg Asp Lys Leu Glu Thr Trp Ala Arg Glu Asp Asp Gln Tyr Asn Gln 
    370                 375                 380                 


Ala His Pro Asn Ser Thr Met Phe Arg Thr Lys Pro Phe Thr Asn Ala 
385                 390                 395                 400 


Gln Trp Gly Arg Gly Asn Thr Gly Ala Thr Ser Ala Ala Ile Ala Ala 
                405                 410                 415     


Leu Ile 
        


