               SEQUENCE LISTING

<110> UNIVERSITA' DEGLI STUDI DI PADOVA

<120> PEPTIDES WITH ANTITUMOR ACTIVITY

<130> P020970WO-01

<150> IT102019000002321
<151> 2019-02-18

<160> 10

<170> BiSSAP 1.3.6

<210> 1
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACPP-HK2 (Activatable Cell Penetrating Peptide targeting
      HexoKinase)

<220> 
<221> NON_STD
<222> 16
<223> beta alanine

<220> 
<221> NON_STD
<222> 32
<223> aminohexanoic acid

<400> 1
Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn Xaa 
1               5                   10                  15      
Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Leu Gly Leu Ala Gly Xaa 
            20                  25                  30          
Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40  

<210> 2
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> SCR control

<220> 
<221> NON_STD
<222> 16
<223> beta alanine

<220> 
<221> NON_STD
<222> 32
<223> aminohexanoic acid

<400> 2
Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg Xaa 
1               5                   10                  15      
Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Leu Gly Leu Ala Gly Xaa 
            20                  25                  30          
Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40  

<210> 3
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACPP-HK2 variant

<220> 
<221> NON_STD
<222> 16
<223> beta alanine

<220> 
<221> NON_STD
<222> 32
<223> aminohexanoic acid

<400> 3
Met Ile Ala Thr His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn Xaa 
1               5                   10                  15      
Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Leu Gly Leu Ala Gly Xaa 
            20                  25                  30          
Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40  

<210> 4
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACPP-HK2 variant

<220> 
<221> NON_STD
<222> 16
<223> beta alanine

<220> 
<221> NON_STD
<222> 32
<223> aminohexanoic acid

<400> 4
Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Ser Glu Leu Asn Xaa 
1               5                   10                  15      
Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Leu Gly Leu Ala Gly Xaa 
            20                  25                  30          
Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40  

<210> 5
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACPP-HK2 variant

<220> 
<221> NON_STD
<222> 16
<223> beta alanine

<220> 
<221> NON_STD
<222> 32
<223> aminohexanoic acid

<400> 5
Met Ile Ala Thr His Leu Leu Ala Tyr Phe Phe Ser Glu Leu Asn Xaa 
1               5                   10                  15      
Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Leu Gly Leu Ala Gly Xaa 
            20                  25                  30          
Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40  

<210> 6
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACPP-HK2 variant

<220> 
<221> NON_STD
<222> 16
<223> beta alanina

<220> 
<221> NON_STD
<222> 32
<223> aminohexanoic acid

<400> 6
Met Ile Ala Ser His Leu Leu Ala Phe Phe Phe Thr Glu Leu Asn Xaa 
1               5                   10                  15      
Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Leu Gly Leu Ala Gly Xaa 
            20                  25                  30          
Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40  

<210> 7
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACPP-HK2 variant

<220> 
<221> NON_STD
<222> 16
<223> beta alanine

<220> 
<221> NON_STD
<222> 32
<223> aminohexanoic acid

<400> 7
Met Ile Ala Ser His Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Asn Xaa 
1               5                   10                  15      
Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Leu Gly Leu Ala Gly Xaa 
            20                  25                  30          
Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40  

<210> 8
<211> 36
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACPP-HK2 II

<220> 
<221> NON_STD
<222> 28
<223> aminohexanoic acid

<400> 8
Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn Arg Arg Arg Arg 
1               5                   10                  15      
Arg Arg Arg Arg Arg Pro Leu Gly Leu Ala Gly Xaa Glu Glu Glu Glu 
            20                  25                  30          
Glu Glu Glu Glu 
        35      

<210> 9
<211> 38
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACPP-HK2 III

<220> 
<221> NON_STD
<222> 30
<223> aminohexanoic acid

<400> 9
Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn Gly Arg Lys Lys 
1               5                   10                  15      
Arg Arg Gln Arg Arg Arg Gly Pro Leu Gly Leu Ala Gly Xaa Glu Glu 
            20                  25                  30          
Glu Glu Glu Glu Glu Glu 
        35              

<210> 10
<211> 38
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACPP-HK2 IV

<220> 
<221> NON_STD
<222> 30
<223> aminohexanoic acid

<400> 10
Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn His Asp Arg Arg 
1               5                   10                  15      
Arg Arg Arg Arg Arg Arg Arg Pro Leu Gly Leu Ala Gly Xaa Glu Glu 
            20                  25                  30          
Glu Glu Glu Glu Glu Glu 
        35              

