                         SEQUENCE LISTING

<110>  King's College London
 
<120>  Therapeutic Agents

<130>  P3468PC00

<150>  1902277.1
<151>  2019-02-19

<160>  31    

<170>  PatentIn version 3.5

<210>  5
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  5
gggccctacg tgctgtctca cacagc                                            26


<210>  6
<211>  26
<212>  DNA
<213>  Mus musculus

<400>  6
gggccctacg tgctgcctcg catggc                                            26


<210>  7
<211>  25
<212>  DNA
<213>  homo sapiens

<400>  7
tgtcacgtcc tgcacgacgc gagta                                             25


<210>  8
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  8
cgcgtcgtgc aggacgtgac aaat                                              24


<210>  9
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  9
ccagcggacg tgcgggaacc cacgtgtagg                                        30


<210>  10
<211>  26
<212>  DNA
<213>  homo sapiens

<400>  10
tccacaggcg tgccgtctga cacgca                                            26


<210>  11
<211>  35
<212>  DNA
<213>  homo sapiens

<400>  11
ccacagtgca tacgtgggct ccaacaggtc ctctt                                  35


<210>  13
<211>  24
<212>  DNA
<213>  Rattus exulans

<400>  13
acagtgcata cgtgggcttc caca                                              24


<210>  14
<211>  17
<212>  DNA
<213>  homo sapiens

<400>  14
actacgtgct gcctagg                                                      17


<210>  15
<211>  26
<212>  DNA
<213>  homo sapiens

<400>  15
cccctcggac gtgactcgga ccacat                                            26


<210>  16
<211>  37
<212>  DNA
<213>  homosapiens

<400>  16
acgctgagtg cgtgcgggac tcggagtacg tgacgga                                37


<210>  17
<211>  26
<212>  DNA
<213>  Mus musculus

<400>  17
cggacgctgg cgtggcacgt cctctc                                            26


<210>  18
<211>  470
<212>  DNA
<213>  Moloney murine sarcoma virus

<400>  18
ctgaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa       60

gaacagatgg aacagctgaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc      120

ccggctcagg gccaagaaca gatggtcccc agatgcggtc cagccctcag cagtttctag      180

agaaccatca gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg      240

aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctcaat      300

aaaagagccc acaacccctc actcggggcg ccagtcctcc gattgactga gtcgcccggg      360

tacccgtgta tccaataaac cctcttgcag ttgcatccga cttgtggtct cgctgttcct      420

tgggagggtc tcctctgagt gattgactac ccgtcagcgg gggtctttca                 470


<210>  19
<211>  606
<212>  DNA
<213>  Moloney murine sarcoma virus

<400>  19
ctagcggccc tacgtgctgt ctcacacagc ctgtctgacg gccctacgtg ctgtctcaca       60

cagcctgtct gacggcccta cgtgctgtct cacacagcct gtctgacggc cctacgtgct      120

gtctcacaca gcctgtctga cggccctacg tgctgtctca cacagcctgt ctgacggccc      180

tacgtgctgt ctcacacagc ctgtctgacg gccctacgtg ctgtctcaca cagcctgtct      240

gacggcccta cgtgctgtct cacacagcct gtctgacggc cctacgtgct gtctcacaca      300

gcctgtctga ctctagagaa ccatcagatg tttccagggt gccccaagga cctgaaatga      360

ccctgtgcct tatttgaact aaccaatcag ttcgcttctc gcttctgttc gcgcgcttct      420

gctccccgag ctcaataaaa gagcccacaa cccctcactc ggggcgccag tcctccgatt      480

gactgagtcg cccgggtacc cgtgtatcca ataaaccctc ttgcagttgc atccgacttg      540

tggtctcgct gttccttggg agggtctcct ctgagtgatt gactacccgt cagcgggggt      600

ctttca                                                                 606


<210>  20
<211>  145
<212>  DNA
<213>  Moloney murine sarcoma virus

<400>  20
gaaccatcag atgtttccag ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga       60

actaaccaat cagttcgctt ctcgcttctg ttcgcgcgct tctgctcccc gagctcaata      120

aaagagccca caacccctca ctcgg                                            145


<210>  21
<211>  107
<212>  DNA
<213>  Moloney murine sarcoma virus

<400>  21
ctagagaacc atcagatgtt tccagggtgc cccaaggacc tgaaatgacc ctgtgcctta       60

tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc gcgcttc                    107


<210>  22
<211>  60
<212>  DNA
<213>  Moloney murine sarcoma virus

<400>  22
tgctccccga gctcaataaa agagcccaca acccctcact cggggcgcca gtcctccgat       60


<210>  23
<211>  52
<212>  DNA
<213>  Moloney murine sarcoma virus

<400>  23
tgactgagtc gcccgggtac ccgtgtatcc aataaaccct cttgcagttg ca               52


<210>  24
<211>  143
<212>  DNA
<213>  Moloney murine sarcoma virus

<400>  24
gcgccagtcc tccgattgac tgagtcgccc gggtacccgt gtatccaata aaccctcttg       60

cagttgcatc cgacttgtgg tctcgctgtt ccttgggagg gtctcctctg agtgattgac      120

tacccgtcag cgggggtctt tca                                              143


<210>  25
<211>  11
<212>  DNA
<213>  Moloney murine sarcoma virus

<400>  25
ggggtctttc a                                                            11


<210>  26
<211>  255
<212>  DNA
<213>  homo sapiens

<400>  26
ggccctacgt gctgtctcac acagcctgtc tgacggccct acgtgctgtc tcacacagcc       60

tgtctgacgg ccctacgtgc tgtctcacac agcctgtctg acggccctac gtgctgtctc      120

acacagcctg tctgacggcc ctacgtgctg tctcacacag cctgtctgac ggccctacgt      180

gctgtctcac acagcctgtc tgacggccct acgtgctgtc tcacacagcc tgtctgacgg      240

ccctacgtgc tgtct                                                       255


<210>  27
<211>  34
<212>  DNA
<213>  homo sapiens

<400>  27
ggccctacgt gctgtctcac acagcctgtc tgac                                   34


<210>  28
<211>  13
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Leu Glu Met Leu Ala Pro Tyr Ile Xaa Met Asp Asp Asp 
1               5                   10              


<210>  29
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
1               5                   10                  15      


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            20                  25                  30          


Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        35                  40                  45              


Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser 
    50                  55                  60                  


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
65                  70                  75                  80  


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                85                  90                  95      


Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            100                 105                 110         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val 
        115                 120                 125             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    130                 135                 140                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
145                 150                 155                 160 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                165                 170                 175     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
            180                 185                 190         


Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln 
        195                 200             


<210>  30
<211>  74
<212>  PRT
<213>  homo sapiens

<400>  30

Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr Glu 
1               5                   10                  15      


Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu Met 
            20                  25                  30          


Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser Phe 
        35                  40                  45              


Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser Ala 
    50                  55                  60                  


Ser Pro Gln Ser Thr Val Thr Val Phe Gln 
65                  70                  


<210>  31
<211>  124
<212>  PRT
<213>  homo sapiens

<400>  31

Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr Glu 
1               5                   10                  15      


Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu Met 
            20                  25                  30          


Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser Phe 
        35                  40                  45              


Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser Ala 
    50                  55                  60                  


Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln Glu 
65                  70                  75                  80  


Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu Lys 
                85                  90                  95      


Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala Ser 
            100                 105                 110         


Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser 
        115                 120                 


<210>  32
<211>  500
<212>  PRT
<213>  fusion

<400>  32

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Gly Val Val Ser His Phe Asn Asp Cys Pro Leu Ser His 
            20                  25                  30          


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
        35                  40                  45              


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
    50                  55                  60                  


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Ala Ala Ala Ile Glu 
65                  70                  75                  80  


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
                85                  90                  95      


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
            100                 105                 110         


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        115                 120                 125             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    130                 135                 140                 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
145                 150                 155                 160 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
                165                 170                 175     


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
            180                 185                 190         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        195                 200                 205             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    210                 215                 220                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
225                 230                 235                 240 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                245                 250                 255     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            260                 265                 270         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        275                 280                 285             


Leu His Met Gln Ala Leu Pro Pro Arg Ala Pro Ala Ala Gly Asp Thr 
    290                 295                 300                 


Ile Ile Ser Leu Asp Phe Gly Ser Asn Asp Thr Glu Thr Asp Asp Gln 
305                 310                 315                 320 


Gln Leu Glu Glu Val Pro Leu Tyr Asn Asp Val Met Leu Pro Ser Pro 
                325                 330                 335     


Asn Glu Lys Leu Gln Asn Ile Asn Leu Ala Met Ser Pro Leu Pro Thr 
            340                 345                 350         


Ala Glu Thr Pro Lys Pro Leu Arg Ser Ser Ala Asp Pro Ala Leu Asn 
        355                 360                 365             


Gln Glu Val Ala Leu Lys Leu Glu Pro Asn Pro Glu Ser Leu Glu Leu 
    370                 375                 380                 


Ser Phe Thr Met Pro Gln Ile Gln Asp Gln Thr Pro Ser Pro Ser Asp 
385                 390                 395                 400 


Gly Ser Thr Arg Gln Ser Ser Pro Glu Pro Asn Ser Pro Ser Glu Tyr 
                405                 410                 415     


Cys Phe Tyr Val Asp Ser Asp Met Val Asn Glu Phe Lys Leu Glu Leu 
            420                 425                 430         


Val Glu Lys Leu Phe Ala Glu Asp Thr Glu Ala Lys Asn Pro Phe Ser 
        435                 440                 445             


Thr Gln Asp Thr Asp Leu Asp Leu Glu Met Leu Ala Pro Tyr Ile Pro 
    450                 455                 460                 


Met Asp Asp Asp Phe Gln Leu Arg Ser Phe Asp Gln Leu Ser Pro Leu 
465                 470                 475                 480 


Glu Ser Ser Ser Ala Ser Pro Glu Ser Ala Ser Pro Gln Ser Thr Val 
                485                 490                 495     


Thr Val Phe Gln 
            500 


<210>  33
<211>  1500
<212>  DNA
<213>  fusion

<400>  33
atgggcccag gagttctgct gctcctgctg gtggccacag cttggcatgg tcagggaggt       60

gtggtgtcgc acttcaatga ctgtccactg tcgcacgatg gatactgcct ccatgatggt      120

gtgtgcatgt acatcgaggc attggacaag tatgcatgca actgtgtcgt cggctacatc      180

ggagagcgat gtcagtaccg agacctgaag tggtgggaac tgagagcggc cgcaattgaa      240

gttatgtatc ctcctcctta cctagacaat gagaagagca atggaaccat tatccatgtg      300

aaagggaaac acctttgtcc aagtccccta tttcccggac cttctaagcc cttttgggtg      360

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt      420

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact      480

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc      540

gcagcctatc gctccagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag      600

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg      660

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag      720

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg      780

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca      840

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg cgccccagcc      900

gctggagaca caatcatatc tttagatttt ggcagcaacg acacagaaac tgatgaccag      960

caacttgagg aagtaccatt atataatgat gtaatgctcc cctcacccaa cgaaaaatta     1020

cagaatataa atttggcaat gtctccatta cccaccgctg aaacgccaaa gccacttcga     1080

agtagtgctg accctgcact caatcaagaa gttgcattaa aattagaacc aaatccagag     1140

tcactggaac tttcttttac catgccccag attcaggatc agacacctag tccttccgat     1200

ggaagcacta gacaaagttc acctgagcct aatagtccca gtgaatattg tttttatgtg     1260

gatagtgata tggtcaatga attcaagttg gaattggtag aaaaactttt tgctgaagac     1320

acagaagcaa agaacccatt ttctactcag gacacagatt tagacttgga gatgttagct     1380

ccctatatcc caatggatga tgacttccag ttacgttcct tcgatcagtt gtcaccatta     1440

gaaagcagtt ccgcaagccc tgaaagcgca agtcctcaaa gcacagttac agtattccag     1500


<210>  34
<211>  55
<212>  PRT
<213>  homo sapiens

<400>  34

Val Val Ser His Phe Asn Asp Cys Pro Leu Ser His Asp Gly Tyr Cys 
1               5                   10                  15      


Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala 
            20                  25                  30          


Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp 
        35                  40                  45              


Leu Lys Trp Trp Glu Leu Arg 
    50                  55  


<210>  35
<211>  112
<212>  PRT
<213>  homo sapiens

<400>  35

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  36
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  36

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


