               SEQUENCE LISTING

<110> B.R.A.H.M.S GmbH
      Linköping University Hospital

<120> METHOD FOR THE DIAGNOSIS OF MACCE IN PATIENTS WHO UNDERWENT GASTROINTESTINAL SURGERY

<130> B.P 1694 WO

<150> EP19020082.4
<151> 2019-02-21
<150> EP19158645.2
<151> 2019-02-21

<160> 27

<170> BiSSAP 1.3.6

<210> 1
<211> 164
<212> PRT
<213> Homo sapiens


<220> 
<223> pre-pro-AVP

<400> 1
Met Pro Asp Thr Met Leu Pro Ala Cys Phe Leu Gly Leu Leu Ala Phe 
1               5                   10                  15      
Ser Ser Ala Cys Tyr Phe Gln Asn Cys Pro Arg Gly Gly Lys Arg Ala 
            20                  25                  30          
Met Ser Asp Leu Glu Leu Arg Gln Cys Leu Pro Cys Gly Pro Gly Gly 
        35                  40                  45              
Lys Gly Arg Cys Phe Gly Pro Ser Ile Cys Cys Ala Asp Glu Leu Gly 
    50                  55                  60                  
Cys Phe Val Gly Thr Ala Glu Ala Leu Arg Cys Gln Glu Glu Asn Tyr 
65                  70                  75                  80  
Leu Pro Ser Pro Cys Gln Ser Gly Gln Lys Ala Cys Gly Ser Gly Gly 
                85                  90                  95      
Arg Cys Ala Ala Phe Gly Val Cys Cys Asn Asp Glu Ser Cys Val Thr 
            100                 105                 110         
Glu Pro Glu Cys Arg Glu Gly Phe His Arg Arg Ala Arg Ala Ser Asp 
        115                 120                 125             
Arg Ser Asn Ala Thr Gln Leu Asp Gly Pro Ala Gly Ala Leu Leu Leu 
    130                 135                 140                 
Arg Leu Val Gln Leu Ala Gly Ala Pro Glu Pro Phe Glu Pro Ala Gln 
145                 150                 155                 160 
Pro Asp Ala Tyr 
                

<210> 2
<211> 145
<212> PRT
<213> Homo sapiens


<220> 
<223> pro-AVP

<400> 2
Cys Tyr Phe Gln Asn Cys Pro Arg Gly Gly Lys Arg Ala Met Ser Asp 
1               5                   10                  15      
Leu Glu Leu Arg Gln Cys Leu Pro Cys Gly Pro Gly Gly Lys Gly Arg 
            20                  25                  30          
Cys Phe Gly Pro Ser Ile Cys Cys Ala Asp Glu Leu Gly Cys Phe Val 
        35                  40                  45              
Gly Thr Ala Glu Ala Leu Arg Cys Gln Glu Glu Asn Tyr Leu Pro Ser 
    50                  55                  60                  
Pro Cys Gln Ser Gly Gln Lys Ala Cys Gly Ser Gly Gly Arg Cys Ala 
65                  70                  75                  80  
Ala Phe Gly Val Cys Cys Asn Asp Glu Ser Cys Val Thr Glu Pro Glu 
                85                  90                  95      
Cys Arg Glu Gly Phe His Arg Arg Ala Arg Ala Ser Asp Arg Ser Asn 
            100                 105                 110         
Ala Thr Gln Leu Asp Gly Pro Ala Gly Ala Leu Leu Leu Arg Leu Val 
        115                 120                 125             
Gln Leu Ala Gly Ala Pro Glu Pro Phe Glu Pro Ala Gln Pro Asp Ala 
    130                 135                 140                 
Tyr 
145 

<210> 3
<211> 39
<212> PRT
<213> Homo sapiens


<220> 
<223> CT-pre-proAVP or copeptin

<400> 3
Ala Ser Asp Arg Ser Asn Ala Thr Gln Leu Asp Gly Pro Ala Gly Ala 
1               5                   10                  15      
Leu Leu Leu Arg Leu Val Gln Leu Ala Gly Ala Pro Glu Pro Phe Glu 
            20                  25                  30          
Pro Ala Gln Pro Asp Ala Tyr 
        35                  

<210> 4
<211> 93
<212> PRT
<213> Homo sapiens


<220> 
<223> Neurophysin II

<400> 4
Ala Met Ser Asp Leu Glu Leu Arg Gln Cys Leu Pro Cys Gly Pro Gly 
1               5                   10                  15      
Gly Lys Gly Arg Cys Phe Gly Pro Ser Ile Cys Cys Ala Asp Glu Leu 
            20                  25                  30          
Gly Cys Phe Val Gly Thr Ala Glu Ala Leu Arg Cys Gln Glu Glu Asn 
        35                  40                  45              
Tyr Leu Pro Ser Pro Cys Gln Ser Gly Gln Lys Ala Cys Gly Ser Gly 
    50                  55                  60                  
Gly Arg Cys Ala Ala Phe Gly Val Cys Cys Asn Asp Glu Ser Cys Val 
65                  70                  75                  80  
Thr Glu Pro Glu Cys Arg Glu Gly Phe His Arg Arg Ala 
                85                  90              

<210> 5
<211> 288
<212> PRT
<213> Homo sapiens


<220> 
<223> cTnT (Isoform-6)

<400> 5
Met Ser Asp Ile Glu Glu Val Val Glu Glu Tyr Glu Glu Glu Glu Gln 
1               5                   10                  15      
Glu Glu Ala Ala Val Glu Glu Gln Glu Glu Ala Ala Glu Glu Asp Ala 
            20                  25                  30          
Glu Ala Glu Ala Glu Thr Glu Glu Thr Arg Ala Glu Glu Asp Glu Glu 
        35                  40                  45              
Glu Glu Glu Ala Lys Glu Ala Glu Asp Gly Pro Met Glu Glu Ser Lys 
    50                  55                  60                  
Pro Lys Pro Arg Ser Phe Met Pro Asn Leu Val Pro Pro Lys Ile Pro 
65                  70                  75                  80  
Asp Gly Glu Arg Val Asp Phe Asp Asp Ile His Arg Lys Arg Met Glu 
                85                  90                  95      
Lys Asp Leu Asn Glu Leu Gln Ala Leu Ile Glu Ala His Phe Glu Asn 
            100                 105                 110         
Arg Lys Lys Glu Glu Glu Glu Leu Val Ser Leu Lys Asp Arg Ile Glu 
        115                 120                 125             
Arg Arg Arg Ala Glu Arg Ala Glu Gln Gln Arg Ile Arg Asn Glu Arg 
    130                 135                 140                 
Glu Lys Glu Arg Gln Asn Arg Leu Ala Glu Glu Arg Ala Arg Arg Glu 
145                 150                 155                 160 
Glu Glu Glu Asn Arg Arg Lys Ala Glu Asp Glu Ala Arg Lys Lys Lys 
                165                 170                 175     
Ala Leu Ser Asn Met Met His Phe Gly Gly Tyr Ile Gln Lys Gln Ala 
            180                 185                 190         
Gln Thr Glu Arg Lys Ser Gly Lys Arg Gln Thr Glu Arg Glu Lys Lys 
        195                 200                 205             
Lys Lys Ile Leu Ala Glu Arg Arg Lys Val Leu Ala Ile Asp His Leu 
    210                 215                 220                 
Asn Glu Asp Gln Leu Arg Glu Lys Ala Lys Glu Leu Trp Gln Ser Ile 
225                 230                 235                 240 
Tyr Asn Leu Glu Ala Glu Lys Phe Asp Leu Gln Glu Lys Phe Lys Gln 
                245                 250                 255     
Gln Lys Tyr Glu Ile Asn Val Leu Arg Asn Arg Ile Asn Asp Asn Gln 
            260                 265                 270         
Lys Val Ser Lys Thr Arg Gly Lys Ala Lys Val Thr Gly Arg Trp Lys 
        275                 280                 285             



<210> 6
<211> 210
<212> PRT
<213> Homo sapiens


<220> 
<223> cTnI

<400> 6
Met Ala Asp Gly Ser Ser Asp Ala Ala Arg Glu Pro Arg Pro Ala Pro 
1               5                   10                  15      
Ala Pro Ile Arg Arg Arg Ser Ser Asn Tyr Arg Ala Tyr Ala Thr Glu 
            20                  25                  30          
Pro His Ala Lys Lys Lys Ser Lys Ile Ser Ala Ser Arg Lys Leu Gln 
        35                  40                  45              
Leu Lys Thr Leu Leu Leu Gln Ile Ala Lys Gln Glu Leu Glu Arg Glu 
    50                  55                  60                  
Ala Glu Glu Arg Arg Gly Glu Lys Gly Arg Ala Leu Ser Thr Arg Cys 
65                  70                  75                  80  
Gln Pro Leu Glu Leu Ala Gly Leu Gly Phe Ala Glu Leu Gln Asp Leu 
                85                  90                  95      
Cys Arg Gln Leu His Ala Arg Val Asp Lys Val Asp Glu Glu Arg Tyr 
            100                 105                 110         
Asp Ile Glu Ala Lys Val Thr Lys Asn Ile Thr Glu Ile Ala Asp Leu 
        115                 120                 125             
Thr Gln Lys Ile Phe Asp Leu Arg Gly Lys Phe Lys Arg Pro Thr Leu 
    130                 135                 140                 
Arg Arg Val Arg Ile Ser Ala Asp Ala Met Met Gln Ala Leu Leu Gly 
145                 150                 155                 160 
Ala Arg Ala Lys Glu Ser Leu Asp Leu Arg Ala His Leu Lys Gln Val 
                165                 170                 175     
Lys Lys Glu Asp Thr Glu Lys Glu Asn Arg Glu Val Gly Asp Trp Arg 
            180                 185                 190         
Lys Asn Ile Asp Ala Leu Ser Gly Met Glu Gly Arg Lys Lys Lys Phe 
        195                 200                 205             
Glu Ser 
    210 

<210> 7
<211> 161
<212> PRT
<213> Homo sapiens


<220> 
<223> TnC

<400> 7
Met Asp Asp Ile Tyr Lys Ala Ala Val Glu Gln Leu Thr Glu Glu Gln 
1               5                   10                  15      
Lys Asn Glu Phe Lys Ala Ala Phe Asp Ile Phe Val Leu Gly Ala Glu 
            20                  25                  30          
Asp Gly Cys Ile Ser Thr Lys Glu Leu Gly Lys Val Met Arg Met Leu 
        35                  40                  45              
Gly Gln Asn Pro Thr Pro Glu Glu Leu Gln Glu Met Ile Asp Glu Val 
    50                  55                  60                  
Asp Glu Asp Gly Ser Gly Thr Val Asp Phe Asp Glu Phe Leu Val Met 
65                  70                  75                  80  
Met Val Arg Cys Met Lys Asp Asp Ser Lys Gly Lys Ser Glu Glu Glu 
                85                  90                  95      
Leu Ser Asp Leu Phe Arg Met Phe Asp Lys Asn Ala Asp Gly Tyr Ile 
            100                 105                 110         
Asp Leu Asp Glu Leu Lys Ile Met Leu Gln Ala Thr Gly Glu Thr Ile 
        115                 120                 125             
Thr Glu Asp Asp Ile Glu Glu Leu Met Lys Asp Gly Asp Lys Asn Asn 
    130                 135                 140                 
Asp Gly Arg Ile Asp Tyr Asp Glu Phe Leu Glu Phe Met Lys Gly Val 
145                 150                 155                 160 
Glu 
    

<210> 8
<211> 134
<212> PRT
<213> Homo sapiens


<220> 
<223> pre-pro-BNP

<400> 8
Met Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      
Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro 
            20                  25                  30          
Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn 
        35                  40                  45              
His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu 
    50                  55                  60                  
Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser Arg 
65                  70                  75                  80  
Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr 
                85                  90                  95      
Thr Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys 
            100                 105                 110         
Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys 
        115                 120                 125             
Lys Val Leu Arg Arg His 
    130                 

<210> 9
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> pro-BNP

<400> 9
His Pro Leu Gly Ser Pro Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly 
1               5                   10                  15      
Leu Gln Glu Gln Arg Asn His Leu Gln Gly Lys Leu Ser Glu Leu Gln 
            20                  25                  30          
Val Glu Gln Thr Ser Leu Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr 
        35                  40                  45              
Gly Val Trp Lys Ser Arg Glu Val Ala Thr Glu Gly Ile Arg Gly His 
    50                  55                  60                  
Arg Lys Met Val Leu Tyr Thr Leu Arg Ala Pro Arg Ser Pro Lys Met 
65                  70                  75                  80  
Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp Arg Ile Ser Ser 
                85                  90                  95      
Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            100                 105             

<210> 10
<211> 76
<212> PRT
<213> Homo sapiens


<220> 
<223> NT-pro-BNP

<400> 10
His Pro Leu Gly Ser Pro Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly 
1               5                   10                  15      
Leu Gln Glu Gln Arg Asn His Leu Gln Gly Lys Leu Ser Glu Leu Gln 
            20                  25                  30          
Val Glu Gln Thr Ser Leu Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr 
        35                  40                  45              
Gly Val Trp Lys Ser Arg Glu Val Ala Thr Glu Gly Ile Arg Gly His 
    50                  55                  60                  
Arg Lys Met Val Leu Tyr Thr Leu Arg Ala Pro Arg 
65                  70                  75      

<210> 11
<211> 32
<212> PRT
<213> Homo sapiens


<220> 
<223> BNP

<400> 11
Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp 
1               5                   10                  15      
Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            20                  25                  30          



<210> 12
<211> 185
<212> PRT
<213> Homo sapiens


<220> 
<223> pre-pro-ADM

<400> 12
Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      
Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          
Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              
Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  
Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  
Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      
Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         
Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             
Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 
Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 
Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     
Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 

<210> 13
<211> 164
<212> PRT
<213> Homo sapiens


<220> 
<223> pro-ADM

<400> 13
Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys Lys Trp Asn Lys Trp 
1               5                   10                  15      
Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met Ser Ser Ser Tyr Pro 
            20                  25                  30          
Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala Gln Thr Leu Ile Arg 
        35                  40                  45              
Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro Glu Asp Ser Ser Pro 
    50                  55                  60                  
Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg Gln Ser Met Asn Asn 
65                  70                  75                  80  
Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe Gly Thr Cys Thr Val 
                85                  90                  95      
Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr Asp Lys Asp Lys Asp 
            100                 105                 110         
Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr Gly Arg Arg 
        115                 120                 125             
Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly Arg Thr Leu Val Ser 
    130                 135                 140                 
Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro Pro Ser Gly Ser Ala 
145                 150                 155                 160 
Pro His Phe Leu 
                

<210> 14
<211> 48
<212> PRT
<213> Homo sapiens


<220> 
<223> MR-pro-ADM

<400> 14
Glu Leu Arg Met Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys 
1               5                   10                  15      
Ala Gly Pro Ala Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala 
            20                  25                  30          
Ser Arg Ser Pro Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val 
        35                  40                  45              



<210> 15
<211> 212
<212> PRT
<213> Homo sapiens


<220> 
<223> pre-pro-ET-1

<400> 15
Met Asp Tyr Leu Leu Met Ile Phe Ser Leu Leu Phe Val Ala Cys Gln 
1               5                   10                  15      
Gly Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Ala Val Gly 
            20                  25                  30          
Glu Asn Gly Gly Glu Lys Pro Thr Pro Ser Pro Pro Trp Arg Leu Arg 
        35                  40                  45              
Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val 
    50                  55                  60                  
Tyr Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val 
65                  70                  75                  80  
Val Pro Tyr Gly Leu Gly Ser Pro Arg Ser Lys Arg Ala Leu Glu Asn 
                85                  90                  95      
Leu Leu Pro Thr Lys Ala Thr Asp Arg Glu Asn Arg Cys Gln Cys Ala 
            100                 105                 110         
Ser Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Gly Lys Glu 
        115                 120                 125             
Leu Arg Ala Glu Asp Ile Met Glu Lys Asp Trp Asn Asn His Lys Lys 
    130                 135                 140                 
Gly Lys Asp Cys Ser Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln Leu 
145                 150                 155                 160 
Val Arg Gly Arg Lys Ile Arg Arg Ser Ser Glu Glu His Leu Arg Gln 
                165                 170                 175     
Thr Arg Ser Glu Thr Met Arg Asn Ser Val Lys Ser Ser Phe His Asp 
            180                 185                 190         
Pro Lys Leu Lys Gly Lys Pro Ser Arg Glu Arg Tyr Val Thr His Asn 
        195                 200                 205             
Arg Ala His Trp 
    210         

<210> 16
<211> 195
<212> PRT
<213> Homo sapiens


<220> 
<223> pro-ET-1

<400> 16
Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Ala Val Gly Glu 
1               5                   10                  15      
Asn Gly Gly Glu Lys Pro Thr Pro Ser Pro Pro Trp Arg Leu Arg Arg 
            20                  25                  30          
Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val Tyr 
        35                  40                  45              
Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val Val 
    50                  55                  60                  
Pro Tyr Gly Leu Gly Ser Pro Arg Ser Lys Arg Ala Leu Glu Asn Leu 
65                  70                  75                  80  
Leu Pro Thr Lys Ala Thr Asp Arg Glu Asn Arg Cys Gln Cys Ala Ser 
                85                  90                  95      
Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Gly Lys Glu Leu 
            100                 105                 110         
Arg Ala Glu Asp Ile Met Glu Lys Asp Trp Asn Asn His Lys Lys Gly 
        115                 120                 125             
Lys Asp Cys Ser Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln Leu Val 
    130                 135                 140                 
Arg Gly Arg Lys Ile Arg Arg Ser Ser Glu Glu His Leu Arg Gln Thr 
145                 150                 155                 160 
Arg Ser Glu Thr Met Arg Asn Ser Val Lys Ser Ser Phe His Asp Pro 
                165                 170                 175     
Lys Leu Lys Gly Lys Pro Ser Arg Glu Arg Tyr Val Thr His Asn Arg 
            180                 185                 190         
Ala His Trp 
        195 

<210> 17
<211> 21
<212> PRT
<213> Homo sapiens


<220> 
<223> ET-1

<400> 17
Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val Tyr Phe Cys His 
1               5                   10                  15      
Leu Asp Ile Ile Trp 
            20      

<210> 18
<211> 45
<212> PRT
<213> Homo sapiens


<220> 
<223> CT-pro-ET-1

<400> 18
Arg Ser Ser Glu Glu His Leu Arg Gln Thr Arg Ser Glu Thr Met Arg 
1               5                   10                  15      
Asn Ser Val Lys Ser Ser Phe His Asp Pro Lys Leu Lys Gly Lys Pro 
            20                  25                  30          
Ser Arg Glu Arg Tyr Val Thr His Asn Arg Ala His Trp 
        35                  40                  45  

<210> 19
<211> 38
<212> PRT
<213> Homo sapiens


<220> 
<223> Big-ET-1

<400> 19
Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val Tyr Phe Cys His 
1               5                   10                  15      
Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val Val Pro Tyr Gly 
            20                  25                  30          
Leu Gly Ser Pro Arg Ser 
        35              

<210> 20
<211> 116
<212> PRT
<213> Homo sapiens


<220> 
<223> PCT

<400> 20
Ala Pro Phe Arg Ser Ala Leu Glu Ser Ser Pro Ala Asp Pro Ala Thr 
1               5                   10                  15      
Leu Ser Glu Asp Glu Ala Arg Leu Leu Leu Ala Ala Leu Val Gln Asp 
            20                  25                  30          
Tyr Val Gln Met Lys Ala Ser Glu Leu Glu Gln Glu Gln Glu Arg Glu 
        35                  40                  45              
Gly Ser Ser Leu Asp Ser Pro Arg Ser Lys Arg Cys Gly Asn Leu Ser 
    50                  55                  60                  
Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Phe Asn Lys Phe His Thr 
65                  70                  75                  80  
Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro Gly Lys Lys Arg Asp 
                85                  90                  95      
Met Ser Ser Asp Leu Glu Arg Asp His Arg Pro His Val Ser Met Pro 
            100                 105                 110         
Gln Asn Ala Asn 
        115     

<210> 21
<211> 153
<212> PRT
<213> Homo sapiens


<220> 
<223> pre-pro-ANP

<400> 21
Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      
Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          
Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              
Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  
Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  
Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      
Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         
Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
        115                 120                 125             
Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu 
    130                 135                 140                 
Gly Cys Asn Ser Phe Arg Tyr Arg Arg 
145                 150             

<210> 22
<211> 126
<212> PRT
<213> Homo sapiens


<220> 
<223> pro-ANP

<400> 22
Asn Pro Met Tyr Asn Ala Val Ser Asn Ala Asp Leu Met Asp Phe Lys 
1               5                   10                  15      
Asn Leu Leu Asp His Leu Glu Glu Lys Met Pro Leu Glu Asp Glu Val 
            20                  25                  30          
Val Pro Pro Gln Val Leu Ser Glu Pro Asn Glu Glu Ala Gly Ala Ala 
        35                  40                  45              
Leu Ser Pro Leu Pro Glu Val Pro Pro Trp Thr Gly Glu Val Ser Pro 
    50                  55                  60                  
Ala Gln Arg Asp Gly Gly Ala Leu Gly Arg Gly Pro Trp Asp Ser Ser 
65                  70                  75                  80  
Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu Thr Ala 
                85                  90                  95      
Pro Arg Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg 
            100                 105                 110         
Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
        115                 120                 125     

<210> 23
<211> 98
<212> PRT
<213> Homo sapiens


<220> 
<223> NT-proANP

<400> 23
Asn Pro Met Tyr Asn Ala Val Ser Asn Ala Asp Leu Met Asp Phe Lys 
1               5                   10                  15      
Asn Leu Leu Asp His Leu Glu Glu Lys Met Pro Leu Glu Asp Glu Val 
            20                  25                  30          
Val Pro Pro Gln Val Leu Ser Glu Pro Asn Glu Glu Ala Gly Ala Ala 
        35                  40                  45              
Leu Ser Pro Leu Pro Glu Val Pro Pro Trp Thr Gly Glu Val Ser Pro 
    50                  55                  60                  
Ala Gln Arg Asp Gly Gly Ala Leu Gly Arg Gly Pro Trp Asp Ser Ser 
65                  70                  75                  80  
Asp Arg Ser Ala Leu Leu Lys Ser Lys Leu Arg Ala Leu Leu Thr Ala 
                85                  90                  95      
Pro Arg 
        

<210> 24
<211> 38
<212> PRT
<213> Homo sapiens


<220> 
<223> MR-proANP

<400> 24
Pro Glu Val Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp 
1               5                   10                  15      
Gly Gly Ala Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala 
            20                  25                  30          
Leu Leu Lys Ser Lys Leu 
        35              

<210> 25
<211> 154
<212> PRT
<213> Homo sapiens


<220> 
<223> Myoglobin

<400> 25
Met Gly Leu Ser Asp Gly Glu Trp Gln Leu Val Leu Asn Val Trp Gly 
1               5                   10                  15      
Lys Val Glu Ala Asp Ile Pro Gly His Gly Gln Glu Val Leu Ile Arg 
            20                  25                  30          
Leu Phe Lys Gly His Pro Glu Thr Leu Glu Lys Phe Asp Lys Phe Lys 
        35                  40                  45              
His Leu Lys Ser Glu Asp Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  
His Gly Ala Thr Val Leu Thr Ala Leu Gly Gly Ile Leu Lys Lys Lys 
65                  70                  75                  80  
Gly His His Glu Ala Glu Ile Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      
Lys His Lys Ile Pro Val Lys Tyr Leu Glu Phe Ile Ser Glu Cys Ile 
            100                 105                 110         
Ile Gln Val Leu Gln Ser Lys His Pro Gly Asp Phe Gly Ala Asp Ala 
        115                 120                 125             
Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Met Ala 
    130                 135                 140                 
Ser Asn Tyr Lys Glu Leu Gly Phe Gln Gly 
145                 150                 

<210> 26
<211> 381
<212> PRT
<213> Homo sapiens


<220> 
<223> Creatine kinase

<400> 26
Met Pro Phe Ser Asn Ser His Asn Ala Leu Lys Leu Arg Phe Pro Ala 
1               5                   10                  15      
Glu Asp Glu Phe Pro Asp Leu Ser Ala His Asn Asn His Met Ala Lys 
            20                  25                  30          
Val Leu Thr Pro Glu Leu Tyr Ala Glu Leu Arg Ala Lys Ser Thr Pro 
        35                  40                  45              
Ser Gly Phe Thr Leu Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  
Gly His Pro Tyr Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  
Ser Tyr Glu Val Phe Lys Asp Leu Phe Asp Pro Ile Ile Glu Asp Arg 
                85                  90                  95      
His Gly Gly Tyr Lys Pro Ser Asp Glu His Lys Thr Asp Leu Asn Pro 
            100                 105                 110         
Asp Asn Leu Gln Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             
Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Phe Cys Leu Pro Pro 
    130                 135                 140                 
His Cys Ser Arg Gly Glu Arg Arg Ala Ile Glu Lys Leu Ala Val Glu 
145                 150                 155                 160 
Ala Leu Ser Ser Leu Asp Gly Asp Leu Ala Gly Arg Tyr Tyr Ala Leu 
                165                 170                 175     
Lys Ser Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         
Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             
Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Thr 
    210                 215                 220                 
Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 
Gln Lys Gly Gly Asn Met Lys Glu Val Phe Thr Arg Phe Cys Thr Gly 
                245                 250                 255     
Leu Thr Gln Ile Glu Thr Leu Phe Lys Ser Lys Asp Tyr Glu Phe Met 
            260                 265                 270         
Trp Asn Pro His Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             
Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Asn Leu Gly Lys 
    290                 295                 300                 
His Glu Lys Phe Ser Glu Val Leu Lys Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 
Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Gly Val Phe Asp Val 
                325                 330                 335     
Ser Asn Ala Asp Arg Leu Gly Phe Ser Glu Val Glu Leu Val Gln Met 
            340                 345                 350         
Val Val Asp Gly Val Lys Leu Leu Ile Glu Met Glu Gln Arg Leu Glu 
        355                 360                 365             
Gln Gly Gln Ala Ile Asp Asp Leu Met Pro Ala Gln Lys 
    370                 375                 380     

<210> 27
<211> 224
<212> PRT
<213> Homo sapiens


<220> 
<223> C-reactive protein

<400> 27
Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      
Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          
Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              
Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  
Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 
65                  70                  75                  80  
Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 
                85                  90                  95      
Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 
            100                 105                 110         
His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 
        115                 120                 125             
Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 
    130                 135                 140                 
Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 
145                 150                 155                 160 
Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 
                165                 170                 175     
Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 
            180                 185                 190         
Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 
        195                 200                 205             
Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
    210                 215                 220                 



