                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  AMINOACYL-TRNA SYNTHETASES AND USES HEREOF

<130>  180091WO02

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  915
<212>  PRT
<213>  Pyrococcus horikoshii

<400>  1

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro Trp 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Val Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Asn Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Glu Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg Thr 
                485                 490                 495     


Lys Glu Glu Lys Gly Glu Glu Leu Val Asp Phe Glu Leu Leu Lys Asp 
            500                 505                 510         


Leu Pro Asp Thr Arg Arg Leu Tyr Tyr Glu Asp Pro Phe Met Lys Glu 
        515                 520                 525             


Phe Asp Ala Lys Val Leu Arg Val Ile Lys Asp Trp Val Ile Leu Asp 
    530                 535                 540                 


Ala Thr Ala Phe Tyr Pro Glu Gly Gly Gly Gln Pro Tyr Asp Thr Gly 
545                 550                 555                 560 


Val Leu Ile Val Asn Gly Arg Glu Val Lys Val Thr Asn Val Gln Lys 
                565                 570                 575     


Val Gly Lys Val Ile Ile His Lys Val Glu Asp Pro Gly Ala Phe Lys 
            580                 585                 590         


Glu Gly Met Ile Val His Gly Lys Ile Asp Trp Lys Arg Arg Ile Gln 
        595                 600                 605             


His Met Arg His His Thr Gly Thr His Val Leu Met Gly Ala Leu Val 
    610                 615                 620                 


Arg Val Leu Gly Arg His Val Trp Gln Ala Gly Ser Gln Leu Thr Thr 
625                 630                 635                 640 


Asp Trp Ala Arg Leu Asp Ile Ser His Tyr Lys Arg Ile Ser Glu Glu 
                645                 650                 655     


Glu Leu Lys Glu Ile Glu Met Leu Ala Asn Arg Ile Val Met Glu Asp 
            660                 665                 670         


Arg Lys Val Thr Trp Glu Trp Leu Pro Arg Thr Thr Ala Glu Gln Lys 
        675                 680                 685             


Tyr Gly Phe Arg Leu Tyr Gln Gly Gly Val Val Pro Gly Arg Glu Ile 
    690                 695                 700                 


Arg Val Val Lys Ile Glu Asp Trp Asp Val Gln Ala Cys Gly Gly Thr 
705                 710                 715                 720 


His Leu Pro Ser Thr Gly Leu Val Gly Pro Ile Lys Ile Leu Arg Thr 
                725                 730                 735     


Glu Arg Ile Gln Asp Gly Val Glu Arg Ile Ile Phe Ala Cys Gly Glu 
            740                 745                 750         


Ala Ala Ile Arg Glu Trp Gln Lys Glu Arg Asp Leu Leu Lys Lys Ala 
        755                 760                 765             


Ser Asn Val Leu Arg Val Pro Pro Glu Lys Leu Pro Glu Thr Ala Glu 
    770                 775                 780                 


Arg Phe Phe Asn Glu Trp Lys Glu Ala Arg Lys Glu Val Asp Lys Leu 
785                 790                 795                 800 


Lys Lys Glu Leu Ala Arg Leu Leu Val Tyr Glu Leu Glu Ser Lys Met 
                805                 810                 815     


Gln Lys Ile Gly Ser Ile Glu Phe Ile Gly Glu Val Val Glu Gly Ser 
            820                 825                 830         


Met Glu Asp Leu Arg Glu Leu Val Glu Lys Leu Lys Lys Pro Lys Arg 
        835                 840                 845             


Val Val Val Leu Ile Ser Arg Asp Gly Tyr Phe Ala Val Ser Val Gly 
    850                 855                 860                 


Ser Glu Val Gly Val Glu Ala Asn Glu Leu Ala Lys Lys Ile Thr Leu 
865                 870                 875                 880 


Ile Ala Gly Gly Gly Gly Gly Gly Arg Arg Asp Ile Ala Gln Gly Lys 
                885                 890                 895     


Val Lys Asp Ile Ser Lys Ala Lys Asp Val Ile Glu Ser Ile Lys Ser 
            900                 905                 910         


Met Phe Ser 
        915 


<210>  2
<211>  78
<212>  DNA
<213>  Pyrococcus horikoshii

<400>  2
gggccggtag ctcagcctgg tatgagcgcc gcccttgcaa ggcggaggcc ccgggttcaa       60

atcccggccg gtccacca                                                     78


<210>  3
<211>  78
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  3
gggccggtag ctcagcctgg tatgagcgcc gccctctaaa ggcggaggcc ccgggttcaa       60

atcccggccg gtccacca                                                     78


<210>  4
<211>  78
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  4
ggaccggtag ctcagcctgg tatgagcgcc gccctctaaa ggcggaggcc ccgggttcaa       60

atcccggccg gtccacca                                                     78


<210>  5
<211>  149
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Aib

<400>  5

Met Ser Xaa Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys Thr Leu 
1               5                   10                  15      


Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr Gln Ser 
            20                  25                  30          


Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro Gly Leu 
        35                  40                  45              


His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala Val Tyr 
    50                  55                  60                  


Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln Ile Ser 
65                  70                  75                  80  


Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala Phe Ser 
                85                  90                  95      


Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu Asp Ser 
            100                 105                 110         


Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val Ala 
        115                 120                 125             


Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln Leu Asp 
    130                 135                 140                 


Leu Ser Pro Gly Cys 
145                 


<210>  6
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  6

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro Trp 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Val Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Asn Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Glu Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  7
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  7

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro Trp 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Asn Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Glu Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  8
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  8

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro Phe 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Val Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Asn Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Glu Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  9
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  9

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Val Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Asn Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Glu Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  10
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  10

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Asn Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Glu Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  11
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  11

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  12
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  12

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Ile Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  13
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  13

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Leu Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  14
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  14

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Leu Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  15
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  15

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Trp Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  16
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  16

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Leu Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Trp Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  17
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  17

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ile Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  18
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  18

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ile Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Ile Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  19
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  19

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Leu Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Ile Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  20
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  20

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ile Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Leu Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  21
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  21

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Leu Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Leu Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  22
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  22

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro Val 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Ile Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  23
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  23

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro Ile 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Ile Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  24
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  24

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro Leu 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Ile Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  25
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  25

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Gly Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Ile Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  26
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  26

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Ser Leu Gly Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  27
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  27

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Ser Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  28
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  28

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Thr Leu Gly Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Val Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  29
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  29

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Cys Leu Gly Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Val Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  30
<211>  495
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide

<400>  30

Met Glu Phe Ile Met Lys Thr Arg Met Phe Glu Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Lys Cys Lys Val Cys Gly Lys Pro Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Gln Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Arg Lys Tyr Thr Leu Asp Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Arg Phe Phe Glu Lys His Glu Ile Tyr Pro His Gly Arg 
65                  70                  75                  80  


Val Lys Arg Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu 
                85                  90                  95      


Val Gly Ala Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu 
            100                 105                 110         


Ala Asp Pro Pro Ala Asn Pro Leu Val Ile Ser Gln Pro Ser Ile Arg 
        115                 120                 125             


Phe Thr Asp Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile 
    130                 135                 140                 


Phe Glu Met Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile 
145                 150                 155                 160 


Tyr Trp Met Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys 
                165                 170                 175     


Glu Leu Lys Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro His 
            180                 185                 190         


Ala Gly Gly Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly 
        195                 200                 205             


Leu Glu Val Ala Ala Leu Gly Phe Met Gln Tyr Lys Lys Ala Pro Glu 
    210                 215                 220                 


Asn Ala Pro Gln Asp Gln Val Val Val Ile Lys Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Pro Met Glu Thr Lys Val Val Asp Phe Gly Tyr Gly Leu Glu Arg Leu 
                245                 250                 255     


Val Trp Met Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly 
            260                 265                 270         


Tyr Val Val Glu Pro Leu Lys Lys Met Ala Gly Ile Glu Lys Ile Asp 
        275                 280                 285             


Glu Lys Ile Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile 
    290                 295                 300                 


Glu Asp Leu Gly Asp Leu Arg Tyr Leu Arg Glu Gln Val Ala Lys Arg 
305                 310                 315                 320 


Val Gly Ile Thr Val Glu Glu Leu Glu Lys Ala Ile Arg Pro Tyr Glu 
                325                 330                 335     


Leu Ile Tyr Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu 
            340                 345                 350         


Ala Asp Gly Val Val Pro Ser Ala Val Lys Ala Gly Tyr Leu Ala Arg 
        355                 360                 365             


Leu Leu Ile Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu 
    370                 375                 380                 


Val Pro Leu Ser Glu Ile Val Ala Leu His Ile Lys Glu Leu His Lys 
385                 390                 395                 400 


Thr Phe Pro Glu Phe Lys Glu Met Glu Asp Ile Ile Leu Glu Met Ile 
                405                 410                 415     


Glu Leu Glu Glu Lys Lys Tyr Ala Glu Thr Leu Arg Arg Gly Ser Asp 
            420                 425                 430         


Leu Val Arg Arg Glu Ile Ala Lys Leu Lys Lys Lys Gly Ile Lys Glu 
        435                 440                 445             


Ile Pro Val Glu Lys Leu Val Thr Phe Tyr Ala Ser His Gly Leu Thr 
    450                 455                 460                 


Pro Glu Ile Val Lys Glu Ile Ala Glu Lys Glu Gly Val Lys Val Asn 
465                 470                 475                 480 


Ile Pro Asp Asn Phe Tyr Ser Met Val Ala Lys Glu Ala Glu Arg 
                485                 490                 495 


<210>  31
<211>  75
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide


<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Aib

<400>  31

Met His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu 
1               5                   10                  15      


Arg His Leu Ile Asp Ile Val Glu Ser Lys Ser Arg Ser Lys Ser Arg 
            20                  25                  30          


Ala Ser Gly Ser Asp Val Lys Asp Asp Gly Asp Arg His Xaa Glu Gly 
        35                  40                  45              


Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys 
    50                  55                  60                  


Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
65                  70                  75  


<210>  32
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<400>  32

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  33
<211>  494
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Formula I


<220>
<221>  MISC_FEATURE
<222>  (1)..(494)
<223>  Xaa designates an unspecified amino acid

<400>  33

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Glu Xaa Gly Xaa Xaa 
1               5                   10                  15      


Xaa Lys Xaa Cys Xaa Xaa Cys Gly Xaa Xaa Phe Trp Thr Xaa Xaa Xaa 
            20                  25                  30          


Xaa Arg Xaa Xaa Cys Gly Asp Xaa Pro Cys Xaa Xaa Tyr Xaa Phe Ile 
        35                  40                  45              


Gly Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Glu Xaa Arg Xaa 
    50                  55                  60                  


Xaa Phe Xaa Xaa Phe Phe Glu Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Arg 
65                  70                  75                  80  


Tyr Pro Val Xaa Xaa Arg Trp Arg Asp Asp Val Xaa Leu Val Gly Ala 
                85                  90                  95      


Ser Ile Xaa Asp Phe Gln Pro Trp Val Xaa Xaa Gly Xaa Xaa Xaa Pro 
            100                 105                 110         


Pro Ala Asn Pro Leu Xaa Ile Ser Gln Pro Xaa Ile Arg Xaa Xaa Asp 
        115                 120                 125             


Xaa Asp Xaa Val Gly Xaa Xaa Gly Arg His Xaa Thr Xaa Phe Glu Met 
    130                 135                 140                 


Met Ala His His Ala Phe Asn Xaa Xaa Xaa Xaa Xaa Xaa Tyr Trp Xaa 
145                 150                 155                 160 


Xaa Glu Thr Val Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Ile Thr Phe Xaa Glu Xaa Xaa Trp Xaa Gly Gly 
            180                 185                 190         


Gly Asn Ala Gly Xaa Xaa Xaa Glu Val Xaa Xaa Xaa Gly Xaa Glu Xaa 
        195                 200                 205             


Ala Thr Leu Val Phe Met Xaa Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Val Asp Thr Gly Tyr Gly Leu Glu Arg Xaa Xaa Trp Xaa 
                245                 250                 255     


Ser Xaa Gly Xaa Pro Thr Xaa Tyr Asp Ala Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Leu Xaa Xaa Xaa Ala Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Ile Leu Xaa Xaa Xaa Xaa Xaa Xaa Ala Gly Xaa Xaa Asp Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Leu Xaa Xaa Leu Arg Xaa Xaa Val Ala Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Glu Leu Xaa Xaa Xaa Xaa Xaa Pro Xaa Glu Xaa Xaa 
                325                 330                 335     


Tyr Ala Ile Ala Asp His Thr Xaa Xaa Leu Xaa Phe Met Leu Xaa Asp 
            340                 345                 350         


Gly Val Xaa Pro Ser Asn Xaa Xaa Ala Gly Tyr Leu Ala Arg Leu Xaa 
        355                 360                 365             


Ile Arg Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Leu Gly Xaa Xaa Xaa Pro 
    370                 375                 380                 


Leu Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Pro Glu Xaa Xaa Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Glu Glu Xaa Xaa Xaa Xaa Xaa Thr Xaa Xaa Arg Gly Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Gly Xaa Xaa Xaa Xaa Pro 
        435                 440                 445             


Xaa Xaa Xaa Leu Xaa Xaa Xaa Tyr Xaa Ser His Gly Xaa Xaa Pro Glu 
    450                 455                 460                 


Xaa Xaa Xaa Glu Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Xaa Pro 
465                 470                 475                 480 


Asp Asn Phe Tyr Xaa Xaa Val Ala Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 


<210>  34
<211>  494
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Formula II


<220>
<221>  MISC_FEATURE
<222>  (1)..(494)
<223>  Xaa designates an unspecified amino acid

<400>  34

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Glu Xaa Gly Xaa Xaa 
1               5                   10                  15      


Arg Lys Xaa Cys Xaa Xaa Cys Gly Xaa Xaa Phe Trp Thr Xaa Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Xaa Pro Cys Asp Xaa Tyr Xaa Phe Ile 
        35                  40                  45              


Gly Xaa Pro Xaa Xaa Xaa Xaa Xaa Tyr Xaa Leu Xaa Glu Xaa Arg Glu 
    50                  55                  60                  


Xaa Phe Leu Xaa Phe Phe Glu Xaa Xaa Xaa His Xaa Arg Xaa Xaa Arg 
65                  70                  75                  80  


Tyr Pro Val Xaa Xaa Arg Trp Arg Asp Asp Val Xaa Leu Val Gly Ala 
                85                  90                  95      


Ser Ile Xaa Asp Phe Gln Pro Trp Val Xaa Ser Gly Xaa Xaa Xaa Pro 
            100                 105                 110         


Pro Ala Asn Pro Leu Xaa Ile Ser Gln Pro Ser Ile Arg Xaa Thr Asp 
        115                 120                 125             


Xaa Asp Asn Val Gly Xaa Thr Gly Arg His Xaa Thr Xaa Phe Glu Met 
    130                 135                 140                 


Met Ala His His Ala Phe Asn Xaa Pro Xaa Xaa Xaa Xaa Tyr Trp Xaa 
145                 150                 155                 160 


Asp Glu Thr Val Glu Xaa Xaa Xaa Xaa Phe Xaa Thr Xaa Xaa Leu Xaa 
                165                 170                 175     


Xaa Xaa Xaa Glu Xaa Ile Thr Phe Lys Glu Xaa Xaa Trp Xaa Gly Gly 
            180                 185                 190         


Gly Asn Ala Gly Pro Xaa Xaa Glu Val Leu Xaa Arg Gly Leu Glu Val 
        195                 200                 205             


Ala Thr Leu Val Phe Met Gln Tyr Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Pro Met Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Val Asp Thr Gly Tyr Gly Leu Glu Arg Xaa Val Trp Xaa 
                245                 250                 255     


Ser Xaa Gly Thr Pro Thr Ala Tyr Asp Ala Val Xaa Xaa Xaa Val Xaa 
            260                 265                 270         


Xaa Xaa Leu Xaa Xaa Xaa Ala Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Ile Leu Xaa Glu Asn Ser Xaa Leu Ala Gly Xaa Xaa Asp Ile Glu Xaa 
    290                 295                 300                 


Xaa Xaa Asp Leu Xaa Xaa Leu Arg Xaa Xaa Val Ala Xaa Xaa Xaa Gly 
305                 310                 315                 320 


Ile Xaa Xaa Xaa Glu Leu Xaa Xaa Xaa Xaa Xaa Pro Xaa Glu Xaa Ile 
                325                 330                 335     


Tyr Ala Ile Ala Asp His Thr Xaa Xaa Leu Xaa Phe Met Leu Xaa Asp 
            340                 345                 350         


Gly Val Xaa Pro Ser Asn Val Lys Ala Gly Tyr Leu Ala Arg Leu Leu 
        355                 360                 365             


Ile Arg Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Leu Gly Leu Xaa Xaa Pro 
    370                 375                 380                 


Leu Xaa Glu Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Pro Glu Xaa Xaa Glu Xaa Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Glu Glu Xaa Xaa Tyr Xaa Xaa Thr Leu Xaa Arg Gly Xaa Xaa Leu Val 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Leu Lys Lys Xaa Gly Xaa Xaa Glu Xaa Pro 
        435                 440                 445             


Leu Glu Xaa Leu Xaa Xaa Xaa Tyr Xaa Ser His Gly Xaa Xaa Pro Glu 
    450                 455                 460                 


Xaa Val Xaa Glu Xaa Ala Xaa Xaa Xaa Gly Xaa Xaa Val Xaa Xaa Pro 
465                 470                 475                 480 


Asp Asn Phe Tyr Xaa Leu Val Ala Xaa Xaa Xaa Glu Xaa Xaa 
                485                 490                 


<210>  35
<211>  493
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Formula III


<220>
<221>  MISC_FEATURE
<222>  (1)..(493)
<223>  Xaa designates an unspecified amino acid

<400>  35

Met Xaa Met Asp Met Xaa Thr Arg Met Phe Lys Glu Glu Gly Trp Ile 
1               5                   10                  15      


Arg Lys Xaa Cys Lys Xaa Cys Gly Lys Xaa Phe Trp Thr Leu Asp Pro 
            20                  25                  30          


Asp Arg Glu Thr Cys Gly Asp Pro Pro Cys Asp Glu Tyr Xaa Phe Ile 
        35                  40                  45              


Gly Lys Pro Gly Ile Pro Lys Lys Tyr Thr Leu Xaa Glu Met Arg Glu 
    50                  55                  60                  


Lys Phe Leu Ser Phe Phe Glu Xaa Xaa Gly His Gly Arg Val Lys Arg 
65                  70                  75                  80  


Tyr Pro Val Leu Pro Arg Trp Arg Asp Asp Val Leu Leu Val Gly Ala 
                85                  90                  95      


Ser Ile Met Asp Phe Gln Pro Trp Val Ile Ser Gly Glu Ala Asp Pro 
            100                 105                 110         


Pro Ala Asn Pro Leu Thr Ile Ser Gln Pro Ser Ile Arg Phe Thr Asp 
        115                 120                 125             


Ile Asp Asn Val Gly Ile Thr Gly Arg His Phe Thr Ile Phe Glu Met 
    130                 135                 140                 


Met Ala His His Ala Phe Asn Tyr Pro Gly Lys Pro Ile Tyr Trp Met 
145                 150                 155                 160 


Asp Glu Thr Val Glu Leu Ala Phe Glu Phe Phe Thr Lys Xaa Leu Gly 
                165                 170                 175     


Met Lys Pro Glu Asp Ile Thr Phe Lys Glu Asn Pro Trp Ala Gly Gly 
            180                 185                 190         


Gly Asn Ala Gly Pro Ala Phe Glu Val Leu Tyr Arg Gly Leu Glu Val 
        195                 200                 205             


Ala Thr Leu Val Phe Met Gln Tyr Lys Xaa Ala Pro Xaa Xaa Ala Xaa 
    210                 215                 220                 


Xaa Xaa Gln Val Val Xaa Ile Lys Gly Asp Xaa Tyr Val Pro Met Xaa 
225                 230                 235                 240 


Thr Xaa Val Val Asp Thr Gly Tyr Gly Leu Glu Arg Leu Val Trp Met 
                245                 250                 255     


Ser Gln Gly Thr Pro Thr Ala Tyr Asp Ala Val Leu Gly Tyr Val Val 
            260                 265                 270         


Glu Pro Leu Lys Xaa Met Ala Gly Xaa Glu Lys Ile Asp Xaa Xaa Ile 
        275                 280                 285             


Leu Met Glu Asn Ser Arg Leu Ala Gly Met Phe Asp Ile Glu Asp Met 
    290                 295                 300                 


Gly Asp Leu Arg Xaa Leu Arg Xaa Xaa Val Ala Xaa Arg Val Gly Ile 
305                 310                 315                 320 


Ser Val Glu Glu Leu Glu Xaa Xaa Xaa Arg Pro Tyr Glu Leu Ile Tyr 
                325                 330                 335     


Ala Ile Ala Asp His Thr Lys Ala Leu Thr Phe Met Leu Ala Asp Gly 
            340                 345                 350         


Val Ile Pro Ser Asn Val Lys Ala Gly Tyr Leu Ala Arg Leu Leu Ile 
        355                 360                 365             


Arg Lys Ser Ile Arg His Leu Arg Glu Leu Gly Leu Glu Xaa Pro Leu 
    370                 375                 380                 


Ser Glu Ile Val Ala Met His Ile Lys Glu Leu Xaa Xaa Thr Phe Pro 
385                 390                 395                 400 


Glu Phe Lys Glu Met Glu Asp Val Ile Leu Asp Ile Xaa Xaa Val Glu 
                405                 410                 415     


Glu Lys Arg Tyr Xaa Glu Thr Leu Xaa Arg Gly Ser Xaa Leu Val Xaa 
            420                 425                 430         


Arg Glu Ile Xaa Lys Leu Lys Lys Xaa Gly Xaa Xaa Glu Xaa Pro Leu 
        435                 440                 445             


Glu Lys Leu Ile Leu Phe Tyr Glu Ser His Gly Leu Thr Pro Glu Ile 
    450                 455                 460                 


Val Xaa Glu Ile Ala Glu Lys Glu Gly Xaa Lys Val Xaa Ile Pro Asp 
465                 470                 475                 480 


Asn Phe Tyr Ser Leu Val Ala Lys Xaa Ala Glu Xaa Xaa 
                485                 490             


