                         SEQUENCE LISTING

<110>  Medizinische Universitt Wien
       Universitt fr Bodenkultur Wien
 
<120>  NEW RECOMBINANT DIAMINE OXIDASE AND ITS USE FOR THE TREATMENT OF 
       DISEASES CHARACTERIZED BY EXCESS HISTAMINE

<130>  MU008P

<150>  EP 19157932.5
<151>  2019-02-19

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  2
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut1

<400>  2

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  3
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut2

<400>  3

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  4
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut3

<400>  4

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Thr Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  5
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut4

<400>  5

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Thr Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  6
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut5

<400>  6

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Thr Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  7
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut6

<400>  7

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Gly Gln Thr Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  8
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut7

<400>  8

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Arg Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  9
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Cysmut

<400>  9

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  10
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut1-Cysmut

<400>  10

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  11
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut2-Cysmut

<400>  11

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  12
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut3-Cysmut

<400>  12

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Thr Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  13
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut4-Cysmut

<400>  13

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Thr Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  14
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut5-Cysmut

<400>  14

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Thr Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  15
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut6-Cysmut

<400>  15

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Gly Gln Thr Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  16
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut7-Cysmut

<400>  16

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Arg Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  17
<211>  2256
<212>  DNA
<213>  Homo sapiens

<400>  17
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa aggaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  18
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut1

<400>  18
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa aggaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  19
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut2

<400>  19
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa aggaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  20
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut3

<400>  20
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa acgaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  21
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut4

<400>  21
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa acgaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  22
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut5

<400>  22
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa acgaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  23
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut6

<400>  23
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcgga cagacgctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  24
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut7

<400>  24
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa aggaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  25
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Cysmut

<400>  25
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa aggaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  26
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut1-Cysmut

<400>  26
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa aggaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  27
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut2-Cysmut

<400>  27
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa aggaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  28
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut3-Cysmut

<400>  28
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa acgaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  29
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut4-Cysmut

<400>  29
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa acgaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  30
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut5-Cysmut

<400>  30
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa acgaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  31
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut6-Cysmut

<400>  31
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcgga cagacgctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  32
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut7-Cysmut

<400>  32
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa aggaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtgtga                               2256


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAO polypeptide

<400>  33

Ser Phe Lys Ala Lys Leu Pro Lys 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAO polypeptide

<400>  34

Ala Phe Lys Ala Lys Leu Pro Thr 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAO polypeptide

<400>  35

Ala Phe Lys Thr Lys Leu Pro Lys 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAO polypeptide

<400>  36

Ser Phe Lys Thr Lys Leu Pro Lys 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAO polypeptide

<400>  37

Ala Phe Lys Thr Lys Leu Pro Thr 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAO polypeptide

<400>  38

Ser Phe Lys Ala Lys Leu Pro Lys 
1               5               


<210>  39
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO

<400>  39

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Cys Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Arg 
785                 790                 795                 800 


Phe Lys Arg Lys Leu Pro Lys Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  40
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut1

<400>  40

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Cys Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Ser 
785                 790                 795                 800 


Phe Lys Arg Lys Leu Pro Lys Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  41
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut2

<400>  41

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Cys Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Arg 
785                 790                 795                 800 


Phe Lys Arg Lys Leu Pro Thr Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  42
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut3

<400>  42

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Cys Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Arg 
785                 790                 795                 800 


Phe Lys Thr Lys Leu Pro Lys Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  43
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut4

<400>  43

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Cys Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Ser 
785                 790                 795                 800 


Phe Lys Thr Lys Leu Pro Lys Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  44
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut5

<400>  44

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Cys Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Arg 
785                 790                 795                 800 


Phe Lys Thr Lys Leu Pro Thr Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  45
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut6

<400>  45

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Cys Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Arg 
785                 790                 795                 800 


Phe Gly Gln Thr Leu Pro Lys Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  46
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut7

<400>  46

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Cys Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Ser 
785                 790                 795                 800 


Phe Lys Arg Lys Leu Pro Thr Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  47
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Cysmut

<400>  47

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Ala Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Arg 
785                 790                 795                 800 


Phe Lys Arg Lys Leu Pro Lys Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  48
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut1-Cysmut

<400>  48

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Ala Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Ser 
785                 790                 795                 800 


Phe Lys Arg Lys Leu Pro Lys Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  49
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut2-Cysmut

<400>  49

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Ala Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Arg 
785                 790                 795                 800 


Phe Lys Arg Lys Leu Pro Thr Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  50
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut3-Cysmut

<400>  50

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Ala Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Arg 
785                 790                 795                 800 


Phe Lys Thr Lys Leu Pro Lys Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  51
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut4-Cysmut

<400>  51

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Ala Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Ser 
785                 790                 795                 800 


Phe Lys Thr Lys Leu Pro Lys Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  52
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut5-Cysmut

<400>  52

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Ala Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Arg 
785                 790                 795                 800 


Phe Lys Thr Lys Leu Pro Thr Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  53
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut6-Cysmut

<400>  53

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Ala Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Arg 
785                 790                 795                 800 


Phe Gly Gln Thr Leu Pro Lys Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  54
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut7-Cysmut

<400>  54

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Ala Asp Lys Thr His Thr Glu Pro Ser Pro Gly 
                245                 250                 255     


Thr Leu Pro Arg Lys Ala Gly Val Phe Ser Asp Leu Ser Asn Gln Glu 
            260                 265                 270         


Leu Lys Ala Val His Ser Phe Leu Trp Ser Lys Lys Glu Leu Arg Leu 
        275                 280                 285             


Gln Pro Ser Ser Thr Thr Thr Met Ala Lys Asn Thr Val Phe Leu Ile 
    290                 295                 300                 


Glu Met Leu Leu Pro Lys Lys Tyr His Val Leu Arg Phe Leu Asp Lys 
305                 310                 315                 320 


Gly Glu Arg His Pro Val Arg Glu Ala Arg Ala Val Ile Phe Phe Gly 
                325                 330                 335     


Asp Gln Glu His Pro Asn Val Thr Glu Phe Ala Val Gly Pro Leu Pro 
            340                 345                 350         


Gly Pro Ala Tyr Met Arg Ala Leu Ser Pro Arg Pro Gly Tyr Gln Ser 
        355                 360                 365             


Ser Trp Ala Ser Arg Pro Ile Ser Thr Ala Glu Tyr Ala Leu Leu Tyr 
    370                 375                 380                 


His Thr Leu Gln Glu Ala Thr Lys Pro Leu His Gln Phe Phe Leu Asn 
385                 390                 395                 400 


Thr Thr Gly Phe Ser Phe Gln Asp Cys His Asp Arg Cys Leu Ala Phe 
                405                 410                 415     


Thr Asp Val Ala Pro Arg Gly Val Ala Ser Gly Gln Arg Arg Ser Trp 
            420                 425                 430         


Leu Ile Ile Gln Arg Tyr Val Glu Gly Tyr Phe Leu His Pro Thr Gly 
        435                 440                 445             


Leu Glu Leu Leu Val Asp His Gly Ser Thr Asp Ala Gly His Trp Ala 
    450                 455                 460                 


Val Glu Gln Val Trp Tyr Asn Gly Lys Phe Tyr Gly Ser Pro Glu Glu 
465                 470                 475                 480 


Leu Ala Arg Lys Tyr Ala Asp Gly Glu Val Asp Val Val Val Leu Glu 
                485                 490                 495     


Asp Pro Leu Pro Gly Gly Lys Gly His Asp Ser Thr Glu Glu Pro Pro 
            500                 505                 510         


Leu Phe Ser Ser His Lys Pro Arg Gly Asp Phe Pro Ser Pro Ile His 
        515                 520                 525             


Val Ser Gly Pro Arg Leu Val Gln Pro His Gly Pro Arg Phe Arg Leu 
    530                 535                 540                 


Glu Gly Asn Ala Val Leu Tyr Gly Gly Trp Ser Phe Ala Phe Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Gly Leu Gln Val Leu Asn Val His Phe Gly Gly Glu 
                565                 570                 575     


Arg Ile Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala Leu Tyr Gly 
            580                 585                 590         


Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Leu Asp Val Gly Trp 
        595                 600                 605             


Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile Asp Cys Pro 
    610                 615                 620                 


Glu Thr Ala Thr Phe Leu Asp Thr Phe His Tyr Tyr Asp Ala Asp Asp 
625                 630                 635                 640 


Pro Val His Tyr Pro Arg Ala Leu Cys Leu Phe Glu Met Pro Thr Gly 
                645                 650                 655     


Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly Gly Phe Asn 
            660                 665                 670         


Phe Tyr Ala Gly Leu Lys Gly Gln Val Leu Val Leu Arg Thr Thr Ser 
        675                 680                 685             


Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe Tyr Pro Asn 
    690                 695                 700                 


Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val His Ala Thr 
705                 710                 715                 720 


Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu His Thr His 
                725                 730                 735     


Leu Ile Gly Asn Ile His Thr His Leu Val His Tyr Arg Val Asp Leu 
            740                 745                 750         


Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Gln Met Lys Leu 
        755                 760                 765             


Glu Asn Ile Thr Asn Pro Trp Ser Pro Arg His Arg Val Val Gln Pro 
    770                 775                 780                 


Thr Leu Glu Gln Thr Gln Tyr Ser Trp Glu Arg Gln Ala Ala Phe Ser 
785                 790                 795                 800 


Phe Lys Arg Lys Leu Pro Thr Tyr Leu Leu Phe Thr Ser Pro Gln Glu 
                805                 810                 815     


Asn Pro Trp Gly His Lys Arg Ser Tyr Arg Leu Gln Ile His Ser Met 
            820                 825                 830         


Ala Asp Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Gln Ala Ile Thr 
        835                 840                 845             


Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu 
    850                 855                 860                 


Cys Ser Ser Ser Ile Tyr His Gln Asn Asp Pro Trp His Pro Pro Val 
865                 870                 875                 880 


Val Phe Glu Gln Phe Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp 
                885                 890                 895     


Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro His Ser Glu 
            900                 905                 910         


Asp Ile Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu 
        915                 920                 925             


Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp 
    930                 935                 940                 


Thr Val Ile Val Trp Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg 
945                 950                 955                 960 


Trp Ile Pro Glu Asp Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr 
                965                 970                 975     


Asn Gly Thr Tyr Arg Pro Val 
            980             


<210>  55
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc

<400>  55

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  56
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut1

<400>  56

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  57
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut2

<400>  57

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  58
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut3

<400>  58

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Thr Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  59
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut4

<400>  59

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Thr Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  60
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut5

<400>  60

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Thr Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  61
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut6

<400>  61

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Gly Gln Thr Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  62
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut7

<400>  62

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Arg Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  63
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Cysmut

<400>  63

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  64
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut1-Cysmut

<400>  64

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  65
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut2-Cysmut

<400>  65

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  66
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut3-Cysmut

<400>  66

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Thr Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  67
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut4-Cysmut

<400>  67

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Thr Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  68
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut5-Cysmut

<400>  68

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Thr Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  69
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut6-Cysmut

<400>  69

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Gly Gln Thr Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  70
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut7-Cysmut

<400>  70

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Ala Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Arg Lys Leu Pro Thr Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val Glu 
            740                 745                 750         


Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        755                 760                 765             


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    770                 775                 780                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
785                 790                 795                 800 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                805                 810                 815     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            820                 825                 830         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        835                 840                 845             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    850                 855                 860                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
865                 870                 875                 880 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                885                 890                 895     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            900                 905                 910         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        915                 920                 925             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    930                 935                 940                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
945                 950                 955                 960 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                965                 970                 975     


Ser Leu Ser Pro Gly Lys 
            980         


<210>  71
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO

<400>  71
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc cctgctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttccgc     2400

ttcaaaagga agctgcccaa gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  72
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut1

<400>  72
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc cctgctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttcagc     2400

ttcaaaagga agctgcccaa gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  73
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut2

<400>  73
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc cctgctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttccgc     2400

ttcaaaagga agctgcccac gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  74
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut3

<400>  74
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc cctgctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttccgc     2400

ttcaaaacga agctgcccaa gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  75
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut4

<400>  75
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc cctgctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttcagc     2400

ttcaaaacga agctgcccaa gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  76
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut5

<400>  76
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc cctgctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttccgc     2400

ttcaaaacga agctgcccac gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  77
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut6

<400>  77
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc cctgctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttccgc     2400

ttcggacaga cgctgcccaa gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  78
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut7

<400>  78
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc cctgctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttcagc     2400

ttcaaaagga agctgcccac gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  79
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Cysmut

<400>  79
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc ccgcctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttccgc     2400

ttcaaaagga agctgcccaa gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  80
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut1-Cysmut

<400>  80
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc ccgcctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttcagc     2400

ttcaaaagga agctgcccaa gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  81
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut2-Cysmut

<400>  81
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc ccgcctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttccgc     2400

ttcaaaagga agctgcccac gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  82
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut3-Cysmut

<400>  82
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc ccgcctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttccgc     2400

ttcaaaacga agctgcccaa gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  83
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut4-Cysmut

<400>  83
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc ccgcctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttcagc     2400

ttcaaaacga agctgcccaa gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  84
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut5-Cysmut

<400>  84
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc ccgcctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttccgc     2400

ttcaaaacga agctgcccac gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  85
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut6-Cysmut

<400>  85
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc ccgcctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttccgc     2400

ttcggacaga cgctgcccaa gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  86
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-hDAO-Hepmut7-Cysmut

<400>  86
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

tgccccccct gccccgcccc ccccgtggcc ggcccctccg tgttcctgtt cccccccaag      120

cccaaggaca ccctgatgat ctccaggacc cccgaggtga cctgcgtggt ggtggacgtg      180

tcccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      240

gccaagacca agcccaggga ggagcagtac aactccacct acagggtggt gtccgtgctg      300

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gtccaacaag      360

ggcctgccct cctccatcga gaagaccatc tccaaggcca agggccagcc cagggagccc      420

caggtgtaca ccctgccccc ctccagggag gagatgacca agaaccaggt gtccctgacc      480

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagtc caacggccag      540

cccgagaaca actacaagac cacccccccc gtgctggact ccgacggctc cttcttcctg      600

tactccaagc tgaccgtgga caagtccagg tggcagcagg gcaacgtgtt ctcctgctcc      660

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgtccct gtcccccggc      720

aaggagccca agtccgccga caagacccac accgagccct ccccggggac tctgcccagg      780

aaggcagggg tgttttcaga cctaagcaac caagagctga aggcagtgca cagcttcctc      840

tggtccaaga aggagctgag gctgcagccc tccagtacca ccaccatggc caagaacacc      900

gtgtttctca tcgagatgct gctgcccaag aagtaccatg tgctgaggtt tctggataaa      960

ggtgaaaggc atcctgtgcg ggaagcccgt gccgtcatct tctttggtga ccaggagcat     1020

cccaatgtca ccgagtttgc tgtggggccc ctgccaggcc ccgcctacat gcgagcactg     1080

tcccccaggc ctgggtacca gtcctcctgg gcatcgaggc ccatctccac agcagagtat     1140

gccctcctct accacaccct gcaggaagcc accaagcccc tgcatcagtt cttcctcaat     1200

accacaggct tctcattcca agactgccat gacagatgcc tggccttcac cgatgtggcc     1260

ccccggggtg tggcttctgg ccagcgccgc agttggctta tcatacagcg ctatgtagaa     1320

ggctactttc tgcaccccac tgggctggag ctcctcgtgg atcatgggag cacagatgct     1380

gggcactggg ccgtggagca ggtgtggtac aacgggaagt tctatgggag cccagaggaa     1440

ctggctcgga agtatgcaga tggagaggtg gacgtggtgg tcctggagga cccgctgcct     1500

gggggcaagg ggcatgacag cacagaggag ccgcccctct tctcctccca caagccccgc     1560

ggggacttcc ccagccccat ccatgtgagc ggcccccgct tggtccagcc ccacggccct     1620

cgcttcaggc tggagggcaa cgctgtgctc tacggcggct ggagctttgc cttccggctg     1680

cgctcctcct ccgggctgca ggtcctgaac gtgcacttcg gcggagagcg cattgcctat     1740

gaggtcagcg tgcaagaggc agtggcgctg tatggaggac acacacctgc aggcatgcag     1800

accaagtacc tcgatgtcgg ctggggcctg ggcagcgtca ctcatgagtt agcccccggc     1860

atcgactgcc cggagaccgc caccttcctg gacactttcc actactatga tgccgatgac     1920

ccggtccatt atccccgagc cctctgcctc tttgaaatgc ccacaggggt gccccttcgg     1980

cggcacttta attccaactt taaaggtggc ttcaacttct atgcggggct gaagggccag     2040

gtgctggtgc tgcggacaac ttcaactgtc tacaattatg attacatttg ggactttatc     2100

ttctacccca acggggtgat ggaggccaag atgcatgcca ctggctacgt ccacgccacc     2160

ttctacaccc ccgaggggct gcgccacggc actcgcctgc acacccacct gattggcaac     2220

atacacactc acttggtgca ctaccgcgta gacctggatg tggcaggcac caagaacagc     2280

ttccagacac tgcagatgaa gctagaaaac atcaccaacc cctggagccc aagacaccgc     2340

gtggtccagc caactctgga gcagacgcag tactcctggg agcgccaggc ggccttcagc     2400

ttcaaaagga agctgcccac gtacctgctc tttaccagcc cccaggagaa cccctggggc     2460

cacaagcgca gctaccgcct gcagatccac tccatggccg accaggtgct gcccccaggc     2520

tggcaggagg agcaggccat cacctgggca aggtaccccc tggcagtgac caagtaccgg     2580

gagtcggagc tgtgcagcag cagcatctac caccagaacg acccctggca cccgcccgtg     2640

gtctttgagc agtttcttca caacaacgag aacattgaaa atgaggacct ggtggcctgg     2700

gtgacggtgg gcttcctgca catcccccac tcagaggaca ttcccaacac agccacacct     2760

gggaactccg tgggcttcct gctccggcca ttcaacttct tcccagagga cccctccctg     2820

gcatccagag acactgtgat cgtgtggcct cgggacaacg gccccaacta cgtccagcgc     2880

tggatccctg aggacaggga ctgctcgatg cctccccctt ttagctacaa tgggacctat     2940

agacctgtgt ga                                                         2952


<210>  87
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc

<400>  87
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa aggaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  88
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut1

<400>  88
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa aggaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  89
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut2

<400>  89
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa aggaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  90
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut3

<400>  90
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa acgaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  91
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut4

<400>  91
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa acgaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  92
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut5

<400>  92
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa acgaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  93
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut6

<400>  93
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcgga cagacgctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  94
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut7

<400>  94
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggccctgct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa aggaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  95
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Cysmut

<400>  95
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa aggaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  96
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut1-Cysmut

<400>  96
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa aggaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  97
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut2-Cysmut

<400>  97
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa aggaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  98
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut3-Cysmut

<400>  98
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa acgaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  99
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut4-Cysmut

<400>  99
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa acgaagctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  100
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut5-Cysmut

<400>  100
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcaaa acgaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  101
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut6-Cysmut

<400>  101
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt ccgcttcgga cagacgctgc ccaagtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  102
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDAO-Fc-Hepmut7-Cysmut

<400>  102
atgccggccc tgggctgggc cgtggctgcc atcctgatgc tgcagacggc catggcggag       60

ccctccccgg ggactctgcc caggaaggca ggggtgtttt cagacctaag caaccaagag      120

ctgaaggcag tgcacagctt cctctggtcc aagaaggagc tgaggctgca gccctccagt      180

accaccacca tggccaagaa caccgtgttt ctcatcgaga tgctgctgcc caagaagtac      240

catgtgctga ggtttctgga taaaggtgaa aggcatcctg tgcgggaagc ccgtgccgtc      300

atcttctttg gtgaccagga gcatcccaat gtcaccgagt ttgctgtggg gcccctgcca      360

gggcccgcct acatgcgagc actgtccccc aggcctgggt accagtcctc ctgggcatcg      420

aggcccatct ccacagcaga gtatgccctc ctctaccaca ccctgcagga agccaccaag      480

cccctgcatc agttcttcct caataccaca ggcttctcat tccaagactg ccatgacaga      540

tgcctggcct tcaccgatgt ggccccccgg ggtgtggctt ctggccagcg ccgcagttgg      600

cttatcatac agcgctatgt agaaggctac tttctgcacc ccactgggct ggagctcctc      660

gtggatcatg ggagcacaga tgctgggcac tgggccgtgg agcaggtgtg gtacaacggg      720

aagttctatg ggagcccaga ggaactggct cggaagtatg cagatggaga ggtggacgtg      780

gtggtcctgg aggacccgct gcctgggggc aaggggcatg acagcacaga ggagccgccc      840

ctcttctcct cccacaagcc ccgcggggac ttccccagcc ccatccatgt gagcggcccc      900

cgcttggtcc agccccacgg ccctcgcttc aggctggagg gcaacgctgt gctctacggc      960

ggctggagct ttgccttccg gctgcgctcc tcctccgggc tgcaggtcct gaacgtgcac     1020

ttcggcggag agcgcattgc ctatgaggtc agcgtgcaag aggcagtggc gctgtatgga     1080

ggacacacac ctgcaggcat gcagaccaag tacctcgatg tcggctgggg cctgggcagc     1140

gtcactcatg agttagcccc cggcatcgac tgcccggaga ccgccacctt cctggacact     1200

ttccactact atgatgccga tgacccggtc cattatcccc gagccctctg cctctttgaa     1260

atgcccacag gggtgcccct tcggcggcac tttaattcca actttaaagg tggcttcaac     1320

ttctatgcgg ggctgaaggg ccaggtgctg gtgctgcgga caacttcaac tgtctacaat     1380

tatgattaca tttgggactt tatcttctac cccaacgggg tgatggaggc caagatgcat     1440

gccactggct acgtccacgc caccttctac acccccgagg ggctgcgcca cggcactcgc     1500

ctgcacaccc acctgattgg caacatacac actcacttgg tgcactaccg cgtagacctg     1560

gatgtggcag gcaccaagaa cagcttccag acactgcaga tgaagctaga aaacatcacc     1620

aacccctgga gcccaagaca ccgcgtggtc cagccaactc tggagcagac gcagtactcc     1680

tgggagcgcc aggcggcctt cagcttcaaa aggaagctgc ccacgtacct gctctttacc     1740

agcccccagg agaacccctg gggccacaag cgcagctacc gcctgcagat ccactccatg     1800

gccgaccagg tgctgccccc aggctggcag gaggagcagg ccatcacctg ggcaaggtac     1860

cccctggcag tgaccaagta ccgggagtcg gagctgtgca gcagcagcat ctaccaccag     1920

aacgacccct ggcacccgcc cgtggtcttt gagcagtttc ttcacaacaa cgagaacatt     1980

gaaaatgagg acctggtggc ctgggtgacg gtgggcttcc tgcacatccc ccactcagag     2040

gacattccca acacagccac acctgggaac tccgtgggct tcctgctccg gccattcaac     2100

ttcttcccag aggacccctc cctggcatcc agagacactg tgatcgtgtg gcctcgggac     2160

aacggcccca actacgtcca gcgctggatc cctgaggaca gggactgctc gatgcctccc     2220

ccttttagct acaatgggac ctatagacct gtggagccca agtccgccga caagacccac     2280

acctgccccc cctgccccgc cccccccgtg gccggcccct ccgtgttcct gttccccccc     2340

aagcccaagg acaccctgat gatctccagg acccccgagg tgacctgcgt ggtggtggac     2400

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac     2460

aacgccaaga ccaagcccag ggaggagcag tacaactcca cctacagggt ggtgtccgtg     2520

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaac     2580

aagggcctgc cctcctccat cgagaagacc atctccaagg ccaagggcca gcccagggag     2640

ccccaggtgt acaccctgcc cccctccagg gaggagatga ccaagaacca ggtgtccctg     2700

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gtccaacggc     2760

cagcccgaga acaactacaa gaccaccccc cccgtgctgg actccgacgg ctccttcttc     2820

ctgtactcca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttctcctgc     2880

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgtccccc     2940

ggcaagtga                                                             2949


<210>  103
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  103

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  104
cagaccacag gcttctcatt c                                                 21


<210>  105
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  105
gaggaagaac tgatgcag                                                     18


<210>  106
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hDAO-Hepmut4 Asn168Gln

<400>  106

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Gln Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Ser Phe Lys Thr Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


