                         SEQUENCE LISTING

<110>  ASCENTAGE PHARMA (SUZHOU) CO., LTD.
       ASCENTAGE PHARMA GROUP CORP LIMITED
 
<120>  TREATMENT METHODS AND BIOMARKERS FOR MDM2 INHIBITORS

<130>  063772-8007WO01

<150>  US 62/809,735
<151>  2019-02-24

<150>  US 62/931,773
<151>  2019-11-06

<150>  CN 202010094504.X
<151>  2020-02-16

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  9171
<212>  DNA
<213>  Homo sapiens

<400>  1
atgagtctag tacttaatga tctgcttatc tgctgccgtc aactagaaca tgatagagct       60

acagaacgaa agaaagaagt tgagaaattt aagcgcctga ttcgagatcc tgaaacaatt      120

aaacatctag atcggcattc agattccaaa caaggaaaat atttgaattg ggatgctgtt      180

tttagatttt tacagaaata tattcagaaa gaaacagaat gtctgagaat agcaaaacca      240

aatgtatcag cctcaacaca agcctccagg cagaaaaaga tgcaggaaat cagtagtttg      300

gtcaaatact tcatcaaatg tgcaaacaga agagcaccta ggctaaaatg tcaagaactc      360

ttaaattata tcatggatac agtgaaagat tcatctaatg gtgctattta cggagctgat      420

tgtagcaaca tactactcaa agacattctt tctgtgagaa aatactggtg tgaaatatct      480

cagcaacagt ggttagaatt gttctctgtg tacttcaggc tctatctgaa accttcacaa      540

gatgttcata gagttttagt ggctagaata attcatgctg ttaccaaagg atgctgttct      600

cagactgacg gattaaattc caaatttttg gacttttttt ccaaggctat tcagtgtgcg      660

agacaagaaa agagctcttc aggtctaaat catatcttag cagctcttac tatcttcctc      720

aagactttgg ctgtcaactt tcgaattcga gtgtgtgaat taggagatga aattcttccc      780

actttgcttt atatttggac tcaacatagg cttaatgatt ctttaaaaga agtcattatt      840

gaattatttc aactgcaaat ttatatccat catccgaaag gagccaaaac ccaagaaaaa      900

ggtgcttatg aatcaacaaa atggagaagt attttataca acttatatga tctgctagtg      960

aatgagataa gtcatatagg aagtagagga aagtattctt caggatttcg taatattgcc     1020

gtcaaagaaa atttgattga attgatggca gatatctgtc accaggtttt taatgaagat     1080

accagatcct tggagatttc tcaatcttac actactacac aaagagaatc tagtgattac     1140

agtgtccctt gcaaaaggaa gaaaatagaa ctaggctggg aagtaataaa agatcacctt     1200

cagaagtcac agaatgattt tgatcttgtg ccttggctac agattgcaac ccaattaata     1260

tcaaagtatc ctgcaagttt acctaactgt gagctgtctc cattactgat gatactatct     1320

cagcttctac cccaacagcg acatggggaa cgtacaccat atgtgttacg atgccttacg     1380

gaagttgcat tgtgtcaaga caagaggtca aacctagaaa gctcacaaaa gtcagattta     1440

ttaaaactct ggaataaaat ttggtgtatt acctttcgtg gtataagttc tgagcaaata     1500

caagctgaaa actttggctt acttggagcc ataattcagg gtagtttagt tgaggttgac     1560

agagaattct ggaagttatt tactgggtca gcctgcagac cttcatgtcc tgcagtatgc     1620

tgtttgactt tggcactgac caccagtata gttccaggaa cggtaaaaat gggaatagag     1680

caaaatatgt gtgaagtaaa tagaagcttt tctttaaagg aatcaataat gaaatggctc     1740

ttattctatc agttagaggg tgacttagaa aatagcacag aagtgcctcc aattcttcac     1800

agtaattttc ctcatcttgt actggagaaa attcttgtga gtctcactat gaaaaactgt     1860

aaagctgcaa tgaatttttt ccaaagcgtg ccagaatgtg aacaccacca aaaagataaa     1920

gaagaacttt cattctcaga agtagaagaa ctatttcttc agacaacttt tgacaagatg     1980

gactttttaa ccattgtgag agaatgtggt atagaaaagc accagtccag tattggcttc     2040

tctgtccacc agaatctcaa ggaatcactg gatcgctgtc ttctgggatt atcagaacag     2100

cttctgaata attactcatc tgagattaca aattcagaaa ctcttgtccg gtgttcacgt     2160

cttttggtgg gtgtccttgg ctgctactgt tacatgggtg taatagctga agaggaagca     2220

tataagtcag aattattcca gaaagccaag tctctaatgc aatgtgcagg agaaagtatc     2280

actctgttta aaaataagac aaatgaggaa ttcagaattg gttccttgag aaatatgatg     2340

cagctatgta cacgttgctt gagcaactgt accaagaaga gtccaaataa gattgcatct     2400

ggctttttcc tgcgattgtt aacatcaaag ctaatgaatg acattgcaga tatttgtaaa     2460

agtttagcat ccttcatcaa aaagccattt gaccgtggag aagtagaatc aatggaagat     2520

gatactaatg gaaatctaat ggaggtggag gatcagtcat ccatgaatct atttaacgat     2580

taccctgata gtagtgttag tgatgcaaac gaacctggag agagccaaag taccataggt     2640

gccattaatc ctttagctga agaatatctg tcaaagcaag atctactttt cttagacatg     2700

ctcaagttct tgtgtttgtg tgtaactact gctcagacca atactgtgtc ctttagggca     2760

gctgatattc ggaggaaatt gttaatgtta attgattcta gcacgctaga acctaccaaa     2820

tccctccacc tgcatatgta tctaatgctt ttaaaggagc ttcctggaga agagtacccc     2880

ttgccaatgg aagatgttct tgaacttctg aaaccactat ccaatgtgtg ttctttgtat     2940

cgtcgtgacc aagatgtttg taaaactatt ttaaaccatg tccttcatgt agtgaaaaac     3000

ctaggtcaaa gcaatatgga ctctgagaac acaagggatg ctcaaggaca gtttcttaca     3060

gtaattggag cattttggca tctaacaaag gagaggaaat atatattctc tgtaagaatg     3120

gccctagtaa attgccttaa aactttgctt gaggctgatc cttattcaaa atgggccatt     3180

cttaatgtaa tgggaaaaga ctttcctgta aatgaagtat ttacacaatt tcttgctgac     3240

aatcatcacc aagttcgcat gttggctgca gagtcaatca atagattgtt ccaggacacg     3300

aagggagatt cttccaggtt actgaaagca cttcctttga agcttcagca aacagctttt     3360

gaaaatgcat acttgaaagc tcaggaagga atgagagaaa tgtcccatag tgctgagaac     3420

cctgaaactt tggatgaaat ttataataga aaatctgttt tactgacgtt gatagctgtg     3480

gttttatcct gtagccctat ctgcgaaaaa caggctttgt ttgccctgtg taaatctgtg     3540

aaagagaatg gattagaacc tcaccttgtg aaaaaggttt tagagaaagt ttctgaaact     3600

tttggatata gacgtttaga agactttatg gcatctcatt tagattatct ggttttggaa     3660

tggctaaatc ttcaagatac tgaatacaac ttatcttctt ttccttttat tttattaaac     3720

tacacaaata ttgaggattt ctatagatct tgttataagg ttttgattcc acatctggtg     3780

attagaagtc attttgatga ggtgaagtcc attgctaatc agattcaaga ggactggaaa     3840

agtcttctaa cagactgctt tccaaagatt cttgtaaata ttcttcctta ttttgcctat     3900

gagggtacca gagacagtgg gatggcacag caaagagaga ctgctaccaa ggtctatgat     3960

atgcttaaaa gtgaaaactt attgggaaaa cagattgatc acttattcat tagtaattta     4020

ccagagattg tggtggagtt attgatgacg ttacatgagc cagcaaattc tagtgccagt     4080

cagagcactg acctctgtga cttttcaggg gatttggatc ctgctcctaa tccacctcat     4140

tttccatcgc atgtgattaa agcaacattt gcctatatca gcaattgtca taaaaccaag     4200

ttaaaaagca ttttagaaat tctttccaaa agccctgatt cctatcagaa aattcttctt     4260

gccatatgtg agcaagcagc tgaaacaaat aatgtttata agaagcacag aattcttaaa     4320

atatatcacc tgtttgttag tttattactg aaagatataa aaagtggctt aggaggagct     4380

tgggcctttg ttcttcgaga cgttatttat actttgattc actatatcaa ccaaaggcct     4440

tcttgtatca tggatgtgtc attacgtagc ttctcccttt gttgtgactt attaagtcag     4500

gtttgccaga cagccgtgac ttactgtaag gatgctctag aaaaccatct tcatgttatt     4560

gttggtacac ttatacccct tgtgtatgag caggtggagg ttcagaaaca ggtattggac     4620

ttgttgaaat acttagtgat agataacaag gataatgaaa acctctatat cacgattaag     4680

cttttagatc cttttcctga ccatgttgtt tttaaggatt tgcgtattac tcagcaaaaa     4740

atcaaataca gtagaggacc cttttcactc ttggaggaaa ttaaccattt tctctcagta     4800

agtgtttatg atgcacttcc attgacaaga cttgaaggac taaaggatct tcgaagacaa     4860

ctggaactac ataaagatca gatggtggac attatgagag cttctcagga taatccgcaa     4920

gatgggatta tggtgaaact agttgtcaat ttgttgcagt tatccaagat ggcaataaac     4980

cacactggtg aaaaagaagt tctagaggct gttggaagct gcttgggaga agtgggtcct     5040

atagatttct ctaccatagc tatacaacat agtaaagatg catcttatac caaggccctt     5100

aagttatttg aagataaaga acttcagtgg accttcataa tgctgaccta cctgaataac     5160

acactggtag aagattgtgt caaagttcga tcagcagctg ttacctgttt gaaaaacatt     5220

ttagccacaa agactggaca tagtttctgg gagatttata agatgacaac agatccaatg     5280

ctggcctatc tacagccttt tagaacatca agaaaaaagt ttttagaagt acccagattt     5340

gacaaagaaa acccttttga aggcctggat gatataaatc tgtggattcc tctaagtgaa     5400

aatcatgaca tttggataaa gacactgact tgtgcttttt tggacagtgg aggcacaaaa     5460

tgtgaaattc ttcaattatt aaagccaatg tgtgaagtga aaactgactt ttgtcagact     5520

gtacttccat acttgattca tgatatttta ctccaagata caaatgaatc atggagaaat     5580

ctgctttcta cacatgttca gggatttttc accagctgtc ttcgacactt ctcgcaaacg     5640

agccgatcca caacccctgc aaacttggat tcagagtcag agcacttttt ccgatgctgt     5700

ttggataaaa aatcacaaag aacaatgctt gctgttgtgg actacatgag aagacaaaag     5760

agaccttctt caggaacaat ttttaatgat gctttctggc tggatttaaa ttatctagaa     5820

gttgccaagg tagctcagtc ttgtgctgct cactttacag ctttactcta tgcagaaatc     5880

tatgcagata agaaaagtat ggatgatcaa gagaaaagaa gtcttgcatt tgaagaagga     5940

agccagagta caactatttc tagcttgagt gaaaaaagta aagaagaaac tggaataagt     6000

ttacaggatc ttctcttaga aatctacaga agtatagggg agccagatag tttgtatggc     6060

tgtggtggag ggaagatgtt acaacccatt actagactac gaacatatga acacgaagca     6120

atgtggggca aagccctagt aacatatgac ctcgaaacag caatcccctc atcaacacgc     6180

caggcaggaa tcattcaggc cttgcagaat ttgggactct gccatattct ttccgtctat     6240

ttaaaaggat tggattatga aaataaagac tggtgtcctg aactagaaga acttcattac     6300

caagcagcat ggaggaatat gcagtgggac cattgcactt ccgtcagcaa agaagtagaa     6360

ggaaccagtt accatgaatc attgtacaat gctctacaat ctctaagaga cagagaattc     6420

tctacatttt atgaaagtct caaatatgcc agagtaaaag aagtggaaga gatgtgtaag     6480

cgcagccttg agtctgtgta ttcgctctat cccacactta gcaggttgca ggccattgga     6540

gagctggaaa gcattgggga gcttttctca agatcagtca cacatagaca actctctgaa     6600

gtatatatta agtggcagaa acactcccag cttctcaagg acagtgattt tagttttcag     6660

gagcctatca tggctctacg cacagtcatt ttggagatcc tgatggaaaa ggaaatggac     6720

aactcacaaa gagaatgtat taaggacatt ctcaccaaac accttgtaga actctctata     6780

ctggccagaa ctttcaagaa cactcagctc cctgaaaggg caatatttca aattaaacag     6840

tacaattcag ttagctgtgg agtctctgag tggcagctgg aagaagcaca agtattctgg     6900

gcaaaaaagg agcagagtct tgccctgagt attctcaagc aaatgatcaa gaagttggat     6960

gccagctgtg cagcgaacaa tcccagccta aaacttacat acacagaatg tctgagggtt     7020

tgtggcaact ggttagcaga aacgtgctta gaaaatcctg cggtcatcat gcagacctat     7080

ctagaaaagg cagtagaagt tgctggaaat tatgatggag aaagtagtga tgagctaaga     7140

aatggaaaaa tgaaggcatt tctctcatta gcccggtttt cagatactca ataccaaaga     7200

attgaaaact acatgaaatc atcggaattt gaaaacaagc aagctctcct gaaaagagcc     7260

aaagaggaag taggtctcct tagggaacat aaaattcaga caaacagata cacagtaaag     7320

gttcagcgag agctggagtt ggatgaatta gccctgcgtg cactgaaaga ggatcgtaaa     7380

cgcttcttat gtaaagcagt tgaaaattat atcaactgct tattaagtgg agaagaacat     7440

gatatgtggg tattccgact ttgttccctc tggcttgaaa attctggagt ttctgaagtc     7500

aatggcatga tgaagagaga cggaatgaag attccaacat ataaattttt gcctcttatg     7560

taccaattgg ctgctagaat ggggaccaag atgatgggag gcctaggatt tcatgaagtc     7620

ctcaataatc taatctctag aatttcaatg gatcaccccc atcacacttt gtttattata     7680

ctggccttag caaatgcaaa cagagatgaa tttctgacta aaccagaggt agccagaaga     7740

agcagaataa ctaaaaatgt gcctaaacaa agctctcagc ttgatgagga tcgaacagag     7800

gctgcaaata gaataatatg tactatcaga agtaggagac ctcagatggt cagaagtgtt     7860

gaggcacttt gtgatgctta tattatatta gcaaacttag atgccactca gtggaagact     7920

cagagaaaag gcataaatat tccagcagac cagccaatta ctaaacttaa gaatttagaa     7980

gatgttgttg tccctactat ggaaattaag gtggaccaca caggagaata tggaaatctg     8040

gtgactatac agtcatttaa agcagaattt cgcttagcag gaggtgtaaa tttaccaaaa     8100

ataatagatt gtgtaggttc cgatggcaag gagaggagac agcttgttaa gggccgtgat     8160

gacctgagac aagatgctgt catgcaacag gtcttccaga tgtgtaatac attactgcag     8220

agaaacacgg aaactaggaa gaggaaatta actatctgta cttataaggt ggttcccctc     8280

tctcagcgaa gtggtgttct tgaatggtgc acaggaactg tccccattgg tgaatttctt     8340

gttaacaatg aagatggtgc tcataaaaga tacaggccaa atgatttcag tgcctttcag     8400

tgccaaaaga aaatgatgga ggtgcaaaaa aagtcttttg aagagaaata tgaagtcttc     8460

atggatgttt gccaaaattt tcaaccagtt ttccgttact tctgcatgga aaaattcttg     8520

gatccagcta tttggtttga gaagcgattg gcttatacgc gcagtgtagc tacttcttct     8580

attgttggtt acatacttgg acttggtgat agacatgtac agaatatctt gataaatgag     8640

cagtcagcag aacttgtaca tatagatcta ggtgttgctt ttgaacaggg caaaatcctt     8700

cctactcctg agacagttcc ttttagactc accagagata ttgtggatgg catgggcatt     8760

acgggtgttg aaggtgtctt cagaagatgc tgtgagaaaa ccatggaagt gatgagaaac     8820

tctcaggaaa ctctgttaac cattgtagag gtccttctat atgatccact ctttgactgg     8880

accatgaatc ctttgaaagc tttgtattta cagcagaggc cggaagatga aactgagctt     8940

caccctactc tgaatgcaga tgaccaagaa tgcaaacgaa atctcagtga tattgaccag     9000

agtttcaaca aagtagctga acgtgtctta atgagactac aagagaaact gaaaggagtg     9060

gaagaaggca ctgtgctcag tgttggtgga caagtgaatt tgctcataca gcaggccata     9120

gaccccaaaa atctcagccg acttttccca ggatggaaag cttgggtgtg a              9171


<210>  2
<211>  3056
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Thr His  Val Gln Gly Phe Phe  Thr Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Thr 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Thr 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Thr Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Thr Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met Cys Lys  Arg Ser Leu 
    2150                 2155                 2160             


Glu Ser  Val Tyr Ser Leu Tyr  Pro Thr Leu Ser Arg  Leu Gln Ala 
    2165                 2170                 2175             


Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu Phe Ser  Arg Ser Val 
    2180                 2185                 2190             


Thr His  Arg Gln Leu Ser Glu  Val Tyr Ile Lys Trp  Gln Lys His 
    2195                 2200                 2205             


Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser Phe Gln  Glu Pro Ile 
    2210                 2215                 2220             


Met Ala  Leu Arg Thr Val Ile  Leu Glu Ile Leu Met  Glu Lys Glu 
    2225                 2230                 2235             


Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys Asp Ile  Leu Thr Lys 
    2240                 2245                 2250             


His Leu  Val Glu Leu Ser Ile  Leu Ala Arg Thr Phe  Lys Asn Thr 
    2255                 2260                 2265             


Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile Lys Gln  Tyr Asn Ser 
    2270                 2275                 2280             


Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu Glu Glu  Ala Gln Val 
    2285                 2290                 2295             


Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala Leu Ser  Ile Leu Lys 
    2300                 2305                 2310             


Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys Ala Ala  Asn Asn Pro 
    2315                 2320                 2325             


Ser Leu  Lys Leu Thr Tyr Thr  Glu Cys Leu Arg Val  Cys Gly Asn 
    2330                 2335                 2340             


Trp Leu  Ala Glu Thr Cys Leu  Glu Asn Pro Ala Val  Ile Met Gln 
    2345                 2350                 2355             


Thr Tyr  Leu Glu Lys Ala Val  Glu Val Ala Gly Asn  Tyr Asp Gly 
    2360                 2365                 2370             


Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys Met Lys  Ala Phe Leu 
    2375                 2380                 2385             


Ser Leu  Ala Arg Phe Ser Asp  Thr Gln Tyr Gln Arg  Ile Glu Asn 
    2390                 2395                 2400             


Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys Gln Ala  Leu Leu Lys 
    2405                 2410                 2415             


Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg Glu His  Lys Ile Gln 
    2420                 2425                 2430             


Thr Asn  Arg Tyr Thr Val Lys  Val Gln Arg Glu Leu  Glu Leu Asp 
    2435                 2440                 2445             


Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp Arg Lys  Arg Phe Leu 
    2450                 2455                 2460             


Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys Leu Leu  Ser Gly Glu 
    2465                 2470                 2475             


Glu His  Asp Met Trp Val Phe  Arg Leu Cys Ser Leu  Trp Leu Glu 
    2480                 2485                 2490             


Asn Ser  Gly Val Ser Glu Val  Asn Gly Met Met Lys  Arg Asp Gly 
    2495                 2500                 2505             


Met Lys  Ile Pro Thr Tyr Lys  Phe Leu Pro Leu Met  Tyr Gln Leu 
    2510                 2515                 2520             


Ala Ala  Arg Met Gly Thr Lys  Met Met Gly Gly Leu  Gly Phe His 
    2525                 2530                 2535             


Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile Ser Met  Asp His Pro 
    2540                 2545                 2550             


His His  Thr Leu Phe Ile Ile  Leu Ala Leu Ala Asn  Ala Asn Arg 
    2555                 2560                 2565             


Asp Glu  Phe Leu Thr Lys Pro  Glu Val Ala Arg Arg  Ser Arg Ile 
    2570                 2575                 2580             


Thr Lys  Asn Val Pro Lys Gln  Ser Ser Gln Leu Asp  Glu Asp Arg 
    2585                 2590                 2595             


Thr Glu  Ala Ala Asn Arg Ile  Ile Cys Thr Ile Arg  Ser Arg Arg 
    2600                 2605                 2610             


Pro Gln  Met Val Arg Ser Val  Glu Ala Leu Cys Asp  Ala Tyr Ile 
    2615                 2620                 2625             


Ile Leu  Ala Asn Leu Asp Ala  Thr Gln Trp Lys Thr  Gln Arg Lys 
    2630                 2635                 2640             


Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile Thr Lys  Leu Lys Asn 
    2645                 2650                 2655             


Leu Glu  Asp Val Val Val Pro  Thr Met Glu Ile Lys  Val Asp His 
    2660                 2665                 2670             


Thr Gly  Glu Tyr Gly Asn Leu  Val Thr Ile Gln Ser  Phe Lys Ala 
    2675                 2680                 2685             


Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu Pro Lys  Ile Ile Asp 
    2690                 2695                 2700             


Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg Gln Leu  Val Lys Gly 
    2705                 2710                 2715             


Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met Gln Gln  Val Phe Gln 
    2720                 2725                 2730             


Met Cys  Asn Thr Leu Leu Gln  Arg Asn Thr Glu Thr  Arg Lys Arg 
    2735                 2740                 2745             


Lys Leu  Thr Ile Cys Thr Tyr  Lys Val Val Pro Leu  Ser Gln Arg 
    2750                 2755                 2760             


Ser Gly  Val Leu Glu Trp Cys  Thr Gly Thr Val Pro  Ile Gly Glu 
    2765                 2770                 2775             


Phe Leu  Val Asn Asn Glu Asp  Gly Ala His Lys Arg  Tyr Arg Pro 
    2780                 2785                 2790             


Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys Lys Met  Met Glu Val 
    2795                 2800                 2805             


Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu Val Phe  Met Asp Val 
    2810                 2815                 2820             


Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr Phe Cys  Met Glu Lys 
    2825                 2830                 2835             


Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys Arg Leu  Ala Tyr Thr 
    2840                 2845                 2850             


Arg Ser  Val Ala Thr Ser Ser  Ile Val Gly Tyr Ile  Leu Gly Leu 
    2855                 2860                 2865             


Gly Asp  Arg His Val Gln Asn  Ile Leu Ile Asn Glu  Gln Ser Ala 
    2870                 2875                 2880             


Glu Leu  Val His Ile Asp Leu  Gly Val Ala Phe Glu  Gln Gly Lys 
    2885                 2890                 2895             


Ile Leu  Pro Thr Pro Glu Thr  Val Pro Phe Arg Leu  Thr Arg Asp 
    2900                 2905                 2910             


Ile Val  Asp Gly Met Gly Ile  Thr Gly Val Glu Gly  Val Phe Arg 
    2915                 2920                 2925             


Arg Cys  Cys Glu Lys Thr Met  Glu Val Met Arg Asn  Ser Gln Glu 
    2930                 2935                 2940             


Thr Leu  Leu Thr Ile Val Glu  Val Leu Leu Tyr Asp  Pro Leu Phe 
    2945                 2950                 2955             


Asp Trp  Thr Met Asn Pro Leu  Lys Ala Leu Tyr Leu  Gln Gln Arg 
    2960                 2965                 2970             


Pro Glu  Asp Glu Thr Glu Leu  His Pro Thr Leu Asn  Ala Asp Asp 
    2975                 2980                 2985             


Gln Glu  Cys Lys Arg Asn Leu  Ser Asp Ile Asp Gln  Ser Phe Asn 
    2990                 2995                 3000             


Lys Val  Ala Glu Arg Val Leu  Met Arg Leu Gln Glu  Lys Leu Lys 
    3005                 3010                 3015             


Gly Val  Glu Glu Gly Thr Val  Leu Ser Val Gly Gly  Gln Val Asn 
    3020                 3025                 3030             


Leu Leu  Ile Gln Gln Ala Ile  Asp Pro Lys Asn Leu  Ser Arg Leu 
    3035                 3040                 3045             


Phe Pro  Gly Trp Lys Ala Trp  Val 
    3050                 3055     


<210>  3
<211>  7935
<212>  DNA
<213>  Homo sapiens

<400>  3
atgggggaac atggcctgga gctggcttcc atgatccccg ccctgcggga gctgggcagt       60

gccacaccag aggaatataa tacagttgta cagaagccaa gacaaattct gtgtcaattc      120

attgaccgga tacttacaga tgtaaatgtt gttgctgtag aacttgtaaa gaaaactgac      180

tctcagccaa cctccgtgat gttgcttgat ttcatccagc atatcatgaa atcctcccca      240

cttatgtttg taaatgtgag tggaagccat gaggccaaag gcagttgtat tgaattcagt      300

aattggatca taacgagact tctgcggatt gcagcaactc cctcctgtca tttgttacac      360

aagaaaatct gtgaagtcat ctgttcatta ttatttcttt ttaaaagcaa gagtcctgct      420

atttttgggg tactcacaaa agaattatta caactttttg aagacttggt ttacctccat      480

agaagaaatg tgatgggtca tgctgtggaa tggccagtgg tcatgagccg atttttaagt      540

caattagatg aacacatggg atatttacaa tcagctcctt tgcagttgat gagtatgcaa      600

aatttagaat ttattgaagt cactttatta atggttctta ctcgtattat tgcaattgtg      660

ttttttagaa ggcaagaact cttactttgg cagataggtt gtgttctgct agagtatggt      720

agtccaaaaa ttaaatccct agcaattagc tttttaacag aactttttca gcttggagga      780

ctaccagcac aaccagctag cacttttttc agctcatttt tggaattatt aaaacacctt      840

gtagaaatgg atactgacca attgaaactc tatgaagagc cattatcaaa gctgataaag      900

acactatttc cctttgaagc agaagcttat agaaatattg aacctgtcta tttaaatatg      960

ctgctggaaa aactctgtgt catgtttgaa gacggtgtgc tcatgcggct taagtctgat     1020

ttgctaaaag cagctttgtg ccatttactg cagtatttcc ttaaatttgt gccagctggg     1080

tatgaatctg ctttacaagt caggaaggtc tatgtgagaa atatttgtaa agctcttttg     1140

gatgtgcttg gaattgaggt agatgcagag tacttgttgg gcccacttta tgcagctttg     1200

aaaatggaaa gtatggaaat cattgaggag attcaatgcc aaactcaaca ggaaaacctc     1260

agcagtaata gtgatggaat atcacccaaa aggcgtcgtc tcagctcgtc tctaaaccct     1320

tctaaaagag caccaaaaca gactgaggaa attaaacatg tggacatgaa ccaaaagagc     1380

atattatgga gtgcactgaa acagaaagct gaatcccttc agatttccct tgaatacagt     1440

ggcctaaaga atcctgttat tgagatgtta gaaggaattg ctgttgtctt acaactgact     1500

gctctgtgta ctgttcattg ttctcatcaa aacatgaact gccgtacttt caaggactgt     1560

caacataaat ccaagaagaa accttctgta gtgataactt ggatgtcatt ggatttttac     1620

acaaaagtgc ttaagagctg tagaagtttg ttagaatctg ttcagaaact ggacctggag     1680

gcaaccattg ataaggtggt gaaaatttat gatgctttga tttatatgca agtaaacagt     1740

tcatttgaag atcatatcct ggaagattta tgtggtatgc tctcacttcc atggatttat     1800

tcccattctg atgatggctg tttaaagttg accacatttg ccgctaatct tctaacatta     1860

agctgtagga tttcagatag ctattcacca caggcacaat cacgatgtgt gtttcttctg     1920

actctgtttc caagaagaat attccttgag tggagaacag cagtttacaa ctgggccctg     1980

cagagctccc atgaagtaat ccgggctagt tgtgttagtg gattttttat cttattgcag     2040

cagcagaatt cttgtaacag agttcccaag attcttatag ataaagtcaa agatgattct     2100

gacattgtca agaaagaatt tgcttctata cttggtcaac ttgtctgtac tcttcacggc     2160

atgttttatc tgacaagttc tttaacagaa cctttctctg aacacggaca tgtggacctc     2220

ttctgtagga acttgaaagc cacttctcaa catgaatgtt catcttctca actaaaagct     2280

tctgtctgca agccattcct tttcctactg aaaaaaaaaa tacctagtcc agtaaaactt     2340

gctttcatag ataatctaca tcatctttgt aagcatcttg attttagaga agatgaaaca     2400

gatgtaaaag cagttcttgg aactttatta aatttaatgg aagatccaga caaagatgtt     2460

agagtggctt ttagtggaaa tatcaagcac atattggaat ccttggactc tgaagatgga     2520

tttataaagg agctttttgt cttaagaatg aaggaagcat atacacatgc ccaaatatca     2580

agaaataatg agctgaagga taccttgatt cttacaacag gggatattgg aagggccgca     2640

aaaggagatt tggtaccatt tgcactctta cacttattgc attgtttgtt atccaagtca     2700

gcatctgtct ctggagcagc atacacagaa attagagctc tggttgcagc taaaagtgtt     2760

aaactgcaaa gttttttcag ccagtataag aaacccatct gtcagttttt ggtagaatcc     2820

cttcactcta gtcagatgac agcacttccg aatactccat gccagaatgc tgacgtgcga     2880

aaacaagatg tggctcacca gagagaaatg gctttaaata cgttgtctga aattgccaac     2940

gttttcgact ttcctgatct taatcgtttt cttactagga cattacaagt tctactacct     3000

gatcttgctg ccaaagcaag ccctgcagct tctgctctca ttcgaacttt aggaaaacaa     3060

ttaaatgtca atcgtagaga gattttaata aacaacttca aatatatttt ttctcatttg     3120

gtctgttctt gttccaaaga tgaattagaa cgtgcccttc attatctgaa gaatgaaaca     3180

gaaattgaac tggggagcct gttgagacaa gatttccaag gattgcataa tgaattattg     3240

ctgcgtattg gagaacacta tcaacaggtt tttaatggtt tgtcaatact tgcctcattt     3300

gcatccagtg atgatccata tcagggcccg agagatatca tatcacctga actgatggct     3360

gattatttac aacccaaatt gttgggcatt ttggcttttt ttaacatgca gttactgagc     3420

tctagtgttg gcattgaaga taagaaaatg gccttgaaca gtttgatgtc tttgatgaag     3480

ttaatgggac ccaaacatgt cagttctgtg agggtgaaga tgatgaccac actgagaact     3540

ggccttcgat tcaaggatga ttttcctgaa ttgtgttgca gagcttggga ctgctttgtt     3600

cgctgcctgg atcatgcttg tctgggctcc cttctcagtc atgtaatagt agctttgtta     3660

cctcttatac acatccagcc taaagaaact gcagctatct tccactacct cataattgaa     3720

aacagggatg ctgtgcaaga ttttcttcat gaaatatatt ttttacctga tcatccagaa     3780

ttaaaaaaga taaaagccgt tctccaggaa tacagaaagg agacctctga gagcactgat     3840

cttcagacaa ctcttcagct ctctatgaag gccattcaac atgaaaatgt cgatgttcgt     3900

attcatgctc ttacaagctt gaaggaaacc ttgtataaaa atcaggaaaa actgataaag     3960

tatgcaacag acagtgaaac agtagaacct attatctcac agttggtgac agtgcttttg     4020

aaaggttgcc aagatgcaaa ctctcaagct cggttgctct gtggggaatg tttaggggaa     4080

ttgggggcga tagatccagg tcgattagat ttctcaacaa ctgaaactca aggaaaagat     4140

tttacatttg tgactggagt agaagattca agctttgcct atggattatt gatggagcta     4200

acaagagctt accttgcgta tgctgataat agccgagctc aagattcagc tgcctatgcc     4260

attcaggagt tgctttctat ttatgactgt agagagatgg agaccaacgg cccaggtcac     4320

caattgtgga ggagatttcc tgagcatgtt cgggaaatac tagaacctca tctaaatacc     4380

agatacaaga gttctcagaa gtcaaccgat tggtctggag taaagaagcc aatttactta     4440

agtaaattgg gtagtaactt tgcagaatgg tcagcatctt gggcaggtta tcttattaca     4500

aaggttcgac atgatcttgc cagtaaaatt ttcacctgct gtagcattat gatgaagcat     4560

gatttcaaag tgaccatcta tcttcttcca catattctgg tgtatgtctt actgggttgt     4620

aatcaagaag atcagcagga ggtttatgca gaaattatgg cagttctaaa gcatgacgat     4680

cagcatacca taaataccca agacattgca tctgatctgt gtcaactcag tacacagact     4740

gtgttctcca tgcttgacca tctcacacag tgggcaaggc acaaatttca ggcactgaaa     4800

gctgagaaat gtccacacag caaatcaaac agaaataagg tagactcaat ggtatctact     4860

gtggattatg aagactatca gagtgtaacc cgttttctag acctcatacc ccaggatact     4920

ctggcagtag cttcctttcg ctccaaagca tacacacgag ctgtaatgca ctttgaatca     4980

tttattacag aaaagaagca aaatattcag gaacatcttg gatttttaca gaaattgtat     5040

gctgctatgc atgaacctga tggagtggcc ggagtcagtg caattagaaa ggcagaacca     5100

tctctaaaag aacagatcct tgaacatgaa agccttggct tgctgaggga tgccactgct     5160

tgttatgaca gggctattca gctagaacca gaccagatca ttcattatca tggtgtagta     5220

aagtccatgt taggtcttgg tcagctgtct actgttatca ctcaggtgaa tggagtgcat     5280

gctaacaggt ccgagtggac agatgaatta aacacgtaca gagtggaagc agcttggaaa     5340

ttgtcacagt gggatttggt ggaaaactat ttggcagcag atggaaaatc tacaacatgg     5400

agtgtcagac tgggacagct attattatca gccaaaaaaa gagatatcac agctttttat     5460

gactcactga aactagtgag agcagaacaa attgtacctc tttcagctgc aagctttgaa     5520

agaggctcct accaacgagg atatgaatat attgtgagat tgcacatgtt atgtgagttg     5580

gagcatagca tcaaaccact tttccagcat tctccaggtg acagttctca agaagattct     5640

ctaaactggg tagctcgact agaaatgacc cagaattcct acagagccaa ggagcctatc     5700

ctggctctcc ggagggcttt actaagcctc aacaaaagac cagattacaa tgaaatggtt     5760

ggagaatgct ggctgcagag tgccagggta gctagaaagg ctggtcacca ccagacagcc     5820

tacaatgctc tccttaatgc aggggaatca cgactcgctg aactgtacgt ggaaagggca     5880

aagtggctct ggtccaaggg tgatgttcac caggcactaa ttgttcttca aaaaggtgtt     5940

gaattatgtt ttcctgaaaa tgaaacccca cctgagggta agaacatgtt aatccatggt     6000

cgagctatgc tactagtggg ccgatttatg gaagaaacag ctaactttga aagcaatgca     6060

attatgaaaa aatataagga tgtgaccgcg tgcctgccag aatgggagga tgggcatttt     6120

taccttgcca agtactatga caaattgatg cccatggtca cagacaacaa aatggaaaag     6180

caaggtgatc tcatccggta tatagttctt cattttggca gatctctaca atatggaaat     6240

cagttcatat atcagtcaat gccacgaatg ttaactctat ggcttgatta tggtacaaag     6300

gcatatgaat gggaaaaagc tggccgctcc gatcgtgtac aaatgaggaa tgatttgggt     6360

aaaataaaca aggttatcac agagcataca aactatttag ctccatatca atttttgact     6420

gctttttcac aattgatctc tcgaatttgt cattctcacg atgaagtttt tgttgtcttg     6480

atggaaataa tagccaaagt atttctagcc tatcctcaac aagcaatgtg gatgatgaca     6540

gctgtgtcaa agtcatctta tcccatgcgt gtgaacagat gcaaggaaat cctcaataaa     6600

gctattcata tgaaaaaatc cttagagaag tttgttggag atgcaactcg cctaacagat     6660

aagcttctag aattgtgcaa taaaccggtt gatggaagta gttccacatt aagcatgagc     6720

actcatttta aaatgcttaa aaagctggta gaagaagcaa catttagtga aatcctcatt     6780

cctctacaat cagtcatgat acctacactt ccatcaattc tgggtaccca tgctaaccat     6840

gctagccatg aaccatttcc tggacattgg gcctatattg cagggtttga tgatatggtg     6900

gaaattcttg cttctcttca gaaaccaaag aagatttctt taaaaggctc agatggaaag     6960

ttctacatca tgatgtgtaa gccaaaagat gacctgagaa aggattgtag actaatggaa     7020

ttcaattcct tgattaataa gtgcttaaga aaagatgcag agtctcgtag aagagaactt     7080

catattcgaa catatgcagt tattccacta aatgatgaat gtgggattat tgaatgggtg     7140

aacaacactg ctggtttgag acctattctg accaaactat ataaagaaaa gggagtgtat     7200

atgacaggaa aagaacttcg ccagtgtatg ctaccaaagt cagcagcttt atctgaaaaa     7260

ctcaaagtat tccgagaatt tctcctgccc aggcatcctc ctatttttca tgagtggttt     7320

ctgagaacat tccctgatcc tacatcatgg tacagtagta gatcagctta ctgccgttcc     7380

actgcagtaa tgtcaatggt tggttatatt ctggggcttg gagaccgtca tggtgaaaat     7440

attctctttg attctttgac tggtgaatgc gtacatgtag atttcaattg tcttttcaat     7500

aagggagaaa cctttgaagt tccagaaatt gtgccatttc gcctgactca taatatggtt     7560

aatggaatgg gtcctatggg aacagagggt ctttttcgaa gagcatgtga agttacaatg     7620

aggctgatgc gtgatcagcg agagccttta atgagtgtct taaagacttt tctacatgat     7680

cctcttgtgg aatggagtaa accagtgaaa gggcattcca aagcgccact gaatgaaact     7740

ggagaagttg tcaatgaaaa ggccaagacc catgttcttg acattgagca gcgactacaa     7800

ggtgtaatca agactcgaaa tagagtgaca ggactgccgt tatctattga aggacatgtg     7860

cattacctta tacaggaagc tactgatgaa aacttactat gccagatgta tcttggttgg     7920

actccatata tgtga                                                      7935


<210>  4
<211>  2644
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg 
1               5                   10                  15      


Glu Leu Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys 
            20                  25                  30          


Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val 
        35                  40                  45              


Asn Val Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr 
    50                  55                  60                  


Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro 
65                  70                  75                  80  


Leu Met Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys 
                85                  90                  95      


Ile Glu Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala 
            100                 105                 110         


Thr Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys 
        115                 120                 125             


Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val 
    130                 135                 140                 


Leu Thr Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His 
145                 150                 155                 160 


Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser 
                165                 170                 175     


Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala 
            180                 185                 190         


Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr 
        195                 200                 205             


Leu Leu Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg 
    210                 215                 220                 


Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly 
225                 230                 235                 240 


Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe 
                245                 250                 255     


Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser 
            260                 265                 270         


Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu 
        275                 280                 285             


Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro 
    290                 295                 300                 


Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met 
305                 310                 315                 320 


Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg 
                325                 330                 335     


Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr 
            340                 345                 350         


Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg 
        355                 360                 365             


Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly 
    370                 375                 380                 


Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu 
385                 390                 395                 400 


Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln 
                405                 410                 415     


Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr 
        435                 440                 445             


Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser 
    450                 455                 460                 


Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser 
465                 470                 475                 480 


Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val 
                485                 490                 495     


Leu Gln Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met 
            500                 505                 510         


Asn Cys Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro 
        515                 520                 525             


Ser Val Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu 
    530                 535                 540                 


Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu 
545                 550                 555                 560 


Ala Thr Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met 
                565                 570                 575     


Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly 
            580                 585                 590         


Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu 
        595                 600                 605             


Lys Leu Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile 
    610                 615                 620                 


Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu 
625                 630                 635                 640 


Thr Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr 
                645                 650                 655     


Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val 
            660                 665                 670         


Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val 
        675                 680                 685             


Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys 
    690                 695                 700                 


Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly 
705                 710                 715                 720 


Met Phe Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly 
                725                 730                 735     


His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu 
            740                 745                 750         


Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe 
        755                 760                 765             


Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp 
    770                 775                 780                 


Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr 
785                 790                 795                 800 


Asp Val Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro 
                805                 810                 815     


Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu 
            820                 825                 830         


Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu 
        835                 840                 845             


Arg Met Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu 
    850                 855                 860                 


Leu Lys Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala 
865                 870                 875                 880 


Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu 
                885                 890                 895     


Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg 
            900                 905                 910         


Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln 
        915                 920                 925             


Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser 
    930                 935                 940                 


Gln Met Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg 
945                 950                 955                 960 


Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser 
                965                 970                 975     


Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr 
            980                 985                 990         


Arg Thr Leu Gln Val Leu Leu Pro  Asp Leu Ala Ala Lys  Ala Ser Pro 
        995                 1000                 1005             


Ala Ala  Ser Ala Leu Ile Arg  Thr Leu Gly Lys Gln  Leu Asn Val 
    1010                 1015                 1020             


Asn Arg  Arg Glu Ile Leu Ile  Asn Asn Phe Lys Tyr  Ile Phe Ser 
    1025                 1030                 1035             


His Leu  Val Cys Ser Cys Ser  Lys Asp Glu Leu Glu  Arg Ala Leu 
    1040                 1045                 1050             


His Tyr  Leu Lys Asn Glu Thr  Glu Ile Glu Leu Gly  Ser Leu Leu 
    1055                 1060                 1065             


Arg Gln  Asp Phe Gln Gly Leu  His Asn Glu Leu Leu  Leu Arg Ile 
    1070                 1075                 1080             


Gly Glu  His Tyr Gln Gln Val  Phe Asn Gly Leu Ser  Ile Leu Ala 
    1085                 1090                 1095             


Ser Phe  Ala Ser Ser Asp Asp  Pro Tyr Gln Gly Pro  Arg Asp Ile 
    1100                 1105                 1110             


Ile Ser  Pro Glu Leu Met Ala  Asp Tyr Leu Gln Pro  Lys Leu Leu 
    1115                 1120                 1125             


Gly Ile  Leu Ala Phe Phe Asn  Met Gln Leu Leu Ser  Ser Ser Val 
    1130                 1135                 1140             


Gly Ile  Glu Asp Lys Lys Met  Ala Leu Asn Ser Leu  Met Ser Leu 
    1145                 1150                 1155             


Met Lys  Leu Met Gly Pro Lys  His Val Ser Ser Val  Arg Val Lys 
    1160                 1165                 1170             


Met Met  Thr Thr Leu Arg Thr  Gly Leu Arg Phe Lys  Asp Asp Phe 
    1175                 1180                 1185             


Pro Glu  Leu Cys Cys Arg Ala  Trp Asp Cys Phe Val  Arg Cys Leu 
    1190                 1195                 1200             


Asp His  Ala Cys Leu Gly Ser  Leu Leu Ser His Val  Ile Val Ala 
    1205                 1210                 1215             


Leu Leu  Pro Leu Ile His Ile  Gln Pro Lys Glu Thr  Ala Ala Ile 
    1220                 1225                 1230             


Phe His  Tyr Leu Ile Ile Glu  Asn Arg Asp Ala Val  Gln Asp Phe 
    1235                 1240                 1245             


Leu His  Glu Ile Tyr Phe Leu  Pro Asp His Pro Glu  Leu Lys Lys 
    1250                 1255                 1260             


Ile Lys  Ala Val Leu Gln Glu  Tyr Arg Lys Glu Thr  Ser Glu Ser 
    1265                 1270                 1275             


Thr Asp  Leu Gln Thr Thr Leu  Gln Leu Ser Met Lys  Ala Ile Gln 
    1280                 1285                 1290             


His Glu  Asn Val Asp Val Arg  Ile His Ala Leu Thr  Ser Leu Lys 
    1295                 1300                 1305             


Glu Thr  Leu Tyr Lys Asn Gln  Glu Lys Leu Ile Lys  Tyr Ala Thr 
    1310                 1315                 1320             


Asp Ser  Glu Thr Val Glu Pro  Ile Ile Ser Gln Leu  Val Thr Val 
    1325                 1330                 1335             


Leu Leu  Lys Gly Cys Gln Asp  Ala Asn Ser Gln Ala  Arg Leu Leu 
    1340                 1345                 1350             


Cys Gly  Glu Cys Leu Gly Glu  Leu Gly Ala Ile Asp  Pro Gly Arg 
    1355                 1360                 1365             


Leu Asp  Phe Ser Thr Thr Glu  Thr Gln Gly Lys Asp  Phe Thr Phe 
    1370                 1375                 1380             


Val Thr  Gly Val Glu Asp Ser  Ser Phe Ala Tyr Gly  Leu Leu Met 
    1385                 1390                 1395             


Glu Leu  Thr Arg Ala Tyr Leu  Ala Tyr Ala Asp Asn  Ser Arg Ala 
    1400                 1405                 1410             


Gln Asp  Ser Ala Ala Tyr Ala  Ile Gln Glu Leu Leu  Ser Ile Tyr 
    1415                 1420                 1425             


Asp Cys  Arg Glu Met Glu Thr  Asn Gly Pro Gly His  Gln Leu Trp 
    1430                 1435                 1440             


Arg Arg  Phe Pro Glu His Val  Arg Glu Ile Leu Glu  Pro His Leu 
    1445                 1450                 1455             


Asn Thr  Arg Tyr Lys Ser Ser  Gln Lys Ser Thr Asp  Trp Ser Gly 
    1460                 1465                 1470             


Val Lys  Lys Pro Ile Tyr Leu  Ser Lys Leu Gly Ser  Asn Phe Ala 
    1475                 1480                 1485             


Glu Trp  Ser Ala Ser Trp Ala  Gly Tyr Leu Ile Thr  Lys Val Arg 
    1490                 1495                 1500             


His Asp  Leu Ala Ser Lys Ile  Phe Thr Cys Cys Ser  Ile Met Met 
    1505                 1510                 1515             


Lys His  Asp Phe Lys Val Thr  Ile Tyr Leu Leu Pro  His Ile Leu 
    1520                 1525                 1530             


Val Tyr  Val Leu Leu Gly Cys  Asn Gln Glu Asp Gln  Gln Glu Val 
    1535                 1540                 1545             


Tyr Ala  Glu Ile Met Ala Val  Leu Lys His Asp Asp  Gln His Thr 
    1550                 1555                 1560             


Ile Asn  Thr Gln Asp Ile Ala  Ser Asp Leu Cys Gln  Leu Ser Thr 
    1565                 1570                 1575             


Gln Thr  Val Phe Ser Met Leu  Asp His Leu Thr Gln  Trp Ala Arg 
    1580                 1585                 1590             


His Lys  Phe Gln Ala Leu Lys  Ala Glu Lys Cys Pro  His Ser Lys 
    1595                 1600                 1605             


Ser Asn  Arg Asn Lys Val Asp  Ser Met Val Ser Thr  Val Asp Tyr 
    1610                 1615                 1620             


Glu Asp  Tyr Gln Ser Val Thr  Arg Phe Leu Asp Leu  Ile Pro Gln 
    1625                 1630                 1635             


Asp Thr  Leu Ala Val Ala Ser  Phe Arg Ser Lys Ala  Tyr Thr Arg 
    1640                 1645                 1650             


Ala Val  Met His Phe Glu Ser  Phe Ile Thr Glu Lys  Lys Gln Asn 
    1655                 1660                 1665             


Ile Gln  Glu His Leu Gly Phe  Leu Gln Lys Leu Tyr  Ala Ala Met 
    1670                 1675                 1680             


His Glu  Pro Asp Gly Val Ala  Gly Val Ser Ala Ile  Arg Lys Ala 
    1685                 1690                 1695             


Glu Pro  Ser Leu Lys Glu Gln  Ile Leu Glu His Glu  Ser Leu Gly 
    1700                 1705                 1710             


Leu Leu  Arg Asp Ala Thr Ala  Cys Tyr Asp Arg Ala  Ile Gln Leu 
    1715                 1720                 1725             


Glu Pro  Asp Gln Ile Ile His  Tyr His Gly Val Val  Lys Ser Met 
    1730                 1735                 1740             


Leu Gly  Leu Gly Gln Leu Ser  Thr Val Ile Thr Gln  Val Asn Gly 
    1745                 1750                 1755             


Val His  Ala Asn Arg Ser Glu  Trp Thr Asp Glu Leu  Asn Thr Tyr 
    1760                 1765                 1770             


Arg Val  Glu Ala Ala Trp Lys  Leu Ser Gln Trp Asp  Leu Val Glu 
    1775                 1780                 1785             


Asn Tyr  Leu Ala Ala Asp Gly  Lys Ser Thr Thr Trp  Ser Val Arg 
    1790                 1795                 1800             


Leu Gly  Gln Leu Leu Leu Ser  Ala Lys Lys Arg Asp  Ile Thr Ala 
    1805                 1810                 1815             


Phe Tyr  Asp Ser Leu Lys Leu  Val Arg Ala Glu Gln  Ile Val Pro 
    1820                 1825                 1830             


Leu Ser  Ala Ala Ser Phe Glu  Arg Gly Ser Tyr Gln  Arg Gly Tyr 
    1835                 1840                 1845             


Glu Tyr  Ile Val Arg Leu His  Met Leu Cys Glu Leu  Glu His Ser 
    1850                 1855                 1860             


Ile Lys  Pro Leu Phe Gln His  Ser Pro Gly Asp Ser  Ser Gln Glu 
    1865                 1870                 1875             


Asp Ser  Leu Asn Trp Val Ala  Arg Leu Glu Met Thr  Gln Asn Ser 
    1880                 1885                 1890             


Tyr Arg  Ala Lys Glu Pro Ile  Leu Ala Leu Arg Arg  Ala Leu Leu 
    1895                 1900                 1905             


Ser Leu  Asn Lys Arg Pro Asp  Tyr Asn Glu Met Val  Gly Glu Cys 
    1910                 1915                 1920             


Trp Leu  Gln Ser Ala Arg Val  Ala Arg Lys Ala Gly  His His Gln 
    1925                 1930                 1935             


Thr Ala  Tyr Asn Ala Leu Leu  Asn Ala Gly Glu Ser  Arg Leu Ala 
    1940                 1945                 1950             


Glu Leu  Tyr Val Glu Arg Ala  Lys Trp Leu Trp Ser  Lys Gly Asp 
    1955                 1960                 1965             


Val His  Gln Ala Leu Ile Val  Leu Gln Lys Gly Val  Glu Leu Cys 
    1970                 1975                 1980             


Phe Pro  Glu Asn Glu Thr Pro  Pro Glu Gly Lys Asn  Met Leu Ile 
    1985                 1990                 1995             


His Gly  Arg Ala Met Leu Leu  Val Gly Arg Phe Met  Glu Glu Thr 
    2000                 2005                 2010             


Ala Asn  Phe Glu Ser Asn Ala  Ile Met Lys Lys Tyr  Lys Asp Val 
    2015                 2020                 2025             


Thr Ala  Cys Leu Pro Glu Trp  Glu Asp Gly His Phe  Tyr Leu Ala 
    2030                 2035                 2040             


Lys Tyr  Tyr Asp Lys Leu Met  Pro Met Val Thr Asp  Asn Lys Met 
    2045                 2050                 2055             


Glu Lys  Gln Gly Asp Leu Ile  Arg Tyr Ile Val Leu  His Phe Gly 
    2060                 2065                 2070             


Arg Ser  Leu Gln Tyr Gly Asn  Gln Phe Ile Tyr Gln  Ser Met Pro 
    2075                 2080                 2085             


Arg Met  Leu Thr Leu Trp Leu  Asp Tyr Gly Thr Lys  Ala Tyr Glu 
    2090                 2095                 2100             


Trp Glu  Lys Ala Gly Arg Ser  Asp Arg Val Gln Met  Arg Asn Asp 
    2105                 2110                 2115             


Leu Gly  Lys Ile Asn Lys Val  Ile Thr Glu His Thr  Asn Tyr Leu 
    2120                 2125                 2130             


Ala Pro  Tyr Gln Phe Leu Thr  Ala Phe Ser Gln Leu  Ile Ser Arg 
    2135                 2140                 2145             


Ile Cys  His Ser His Asp Glu  Val Phe Val Val Leu  Met Glu Ile 
    2150                 2155                 2160             


Ile Ala  Lys Val Phe Leu Ala  Tyr Pro Gln Gln Ala  Met Trp Met 
    2165                 2170                 2175             


Met Thr  Ala Val Ser Lys Ser  Ser Tyr Pro Met Arg  Val Asn Arg 
    2180                 2185                 2190             


Cys Lys  Glu Ile Leu Asn Lys  Ala Ile His Met Lys  Lys Ser Leu 
    2195                 2200                 2205             


Glu Lys  Phe Val Gly Asp Ala  Thr Arg Leu Thr Asp  Lys Leu Leu 
    2210                 2215                 2220             


Glu Leu  Cys Asn Lys Pro Val  Asp Gly Ser Ser Ser  Thr Leu Ser 
    2225                 2230                 2235             


Met Ser  Thr His Phe Lys Met  Leu Lys Lys Leu Val  Glu Glu Ala 
    2240                 2245                 2250             


Thr Phe  Ser Glu Ile Leu Ile  Pro Leu Gln Ser Val  Met Ile Pro 
    2255                 2260                 2265             


Thr Leu  Pro Ser Ile Leu Gly  Thr His Ala Asn His  Ala Ser His 
    2270                 2275                 2280             


Glu Pro  Phe Pro Gly His Trp  Ala Tyr Ile Ala Gly  Phe Asp Asp 
    2285                 2290                 2295             


Met Val  Glu Ile Leu Ala Ser  Leu Gln Lys Pro Lys  Lys Ile Ser 
    2300                 2305                 2310             


Leu Lys  Gly Ser Asp Gly Lys  Phe Tyr Ile Met Met  Cys Lys Pro 
    2315                 2320                 2325             


Lys Asp  Asp Leu Arg Lys Asp  Cys Arg Leu Met Glu  Phe Asn Ser 
    2330                 2335                 2340             


Leu Ile  Asn Lys Cys Leu Arg  Lys Asp Ala Glu Ser  Arg Arg Arg 
    2345                 2350                 2355             


Glu Leu  His Ile Arg Thr Tyr  Ala Val Ile Pro Leu  Asn Asp Glu 
    2360                 2365                 2370             


Cys Gly  Ile Ile Glu Trp Val  Asn Asn Thr Ala Gly  Leu Arg Pro 
    2375                 2380                 2385             


Ile Leu  Thr Lys Leu Tyr Lys  Glu Lys Gly Val Tyr  Met Thr Gly 
    2390                 2395                 2400             


Lys Glu  Leu Arg Gln Cys Met  Leu Pro Lys Ser Ala  Ala Leu Ser 
    2405                 2410                 2415             


Glu Lys  Leu Lys Val Phe Arg  Glu Phe Leu Leu Pro  Arg His Pro 
    2420                 2425                 2430             


Pro Ile  Phe His Glu Trp Phe  Leu Arg Thr Phe Pro  Asp Pro Thr 
    2435                 2440                 2445             


Ser Trp  Tyr Ser Ser Arg Ser  Ala Tyr Cys Arg Ser  Thr Ala Val 
    2450                 2455                 2460             


Met Ser  Met Val Gly Tyr Ile  Leu Gly Leu Gly Asp  Arg His Gly 
    2465                 2470                 2475             


Glu Asn  Ile Leu Phe Asp Ser  Leu Thr Gly Glu Cys  Val His Val 
    2480                 2485                 2490             


Asp Phe  Asn Cys Leu Phe Asn  Lys Gly Glu Thr Phe  Glu Val Pro 
    2495                 2500                 2505             


Glu Ile  Val Pro Phe Arg Leu  Thr His Asn Met Val  Asn Gly Met 
    2510                 2515                 2520             


Gly Pro  Met Gly Thr Glu Gly  Leu Phe Arg Arg Ala  Cys Glu Val 
    2525                 2530                 2535             


Thr Met  Arg Leu Met Arg Asp  Gln Arg Glu Pro Leu  Met Ser Val 
    2540                 2545                 2550             


Leu Lys  Thr Phe Leu His Asp  Pro Leu Val Glu Trp  Ser Lys Pro 
    2555                 2560                 2565             


Val Lys  Gly His Ser Lys Ala  Pro Leu Asn Glu Thr  Gly Glu Val 
    2570                 2575                 2580             


Val Asn  Glu Lys Ala Lys Thr  His Val Leu Asp Ile  Glu Gln Arg 
    2585                 2590                 2595             


Leu Gln  Gly Val Ile Lys Thr  Arg Asn Arg Val Thr  Gly Leu Pro 
    2600                 2605                 2610             


Leu Ser  Ile Glu Gly His Val  His Tyr Leu Ile Gln  Glu Ala Thr 
    2615                 2620                 2625             


Asp Glu  Asn Leu Leu Cys Gln  Met Tyr Leu Gly Trp  Thr Pro Tyr 
    2630                 2635                 2640             


Met 
    


<210>  5
<211>  1494
<212>  DNA
<213>  Homo sapiens

<400>  5
atggtgagga gcaggcaaat gtgcaatacc aacatgtctg tacctactga tggtgctgta       60

accacctcac agattccagc ttcggaacaa gagaccctgg ttagaccaaa gccattgctt      120

ttgaagttat taaagtctgt tggtgcacaa aaagacactt atactatgaa agaggttctt      180

ttttatcttg gccagtatat tatgactaaa cgattatatg atgagaagca acaacatatt      240

gtatattgtt caaatgatct tctaggagat ttgtttggcg tgccaagctt ctctgtgaaa      300

gagcacagga aaatatatac catgatctac aggaacttgg tagtagtcaa tcagcaggaa      360

tcatcggact caggtacatc tgtgagtgag aacaggtgtc accttgaagg tgggagtgat      420

caaaaggacc ttgtacaaga gcttcaggaa gagaaacctt catcttcaca tttggtttct      480

agaccatcta cctcatctag aaggagagca attagtgaga cagaagaaaa ttcagatgaa      540

ttatctggtg aacgacaaag aaaacgccac aaatctgata gtatttccct ttcctttgat      600

gaaagcctgg ctctgtgtgt aataagggag atatgttgtg aaagaagcag tagcagtgaa      660

tctacaggga cgccatcgaa tccggatctt gatgctggtg taagtgaaca ttcaggtgat      720

tggttggatc aggattcagt ttcagatcag tttagtgtag aatttgaagt tgaatctctc      780

gactcagaag attatagcct tagtgaagaa ggacaagaac tctcagatga agatgatgag      840

gtatatcaag ttactgtgta tcaggcaggg gagagtgata cagattcatt tgaagaagat      900

cctgaaattt ccttagctga ctattggaaa tgcacttcat gcaatgaaat gaatcccccc      960

cttccatcac attgcaacag atgttgggcc cttcgtgaga attggcttcc tgaagataaa     1020

gggaaagata aaggggaaat ctctgagaaa gccaaactgg aaaactcaac acaagctgaa     1080

gagggctttg atgttcctga ttgtaaaaaa actatagtga atgattccag agagtcatgt     1140

gttgaggaaa atgatgataa aattacacaa gcttcacaat cacaagaaag tgaagactat     1200

tctcagccat caacttctag tagcattatt tatagcagcc aagaagatgt gaaagagttt     1260

gaaagggaag aaacccaaga caaagaagag agtgtggaat ctagtttgcc ccttaatgcc     1320

attgaacctt gtgtgatttg tcaaggtcga cctaaaaatg gttgcattgt ccatggcaaa     1380

acaggacatc ttatggcctg ctttacatgt gcaaagaagc taaagaaaag gaataagccc     1440

tgcccagtat gtagacaacc aattcaaatg attgtgctaa cttatttccc ctag           1494


<210>  6
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Arg Ser Arg Gln Met Cys Asn Thr Asn Met Ser Val Pro Thr 
1               5                   10                  15      


Asp Gly Ala Val Thr Thr Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr 
            20                  25                  30          


Leu Val Arg Pro Lys Pro Leu Leu Leu Lys Leu Leu Lys Ser Val Gly 
        35                  40                  45              


Ala Gln Lys Asp Thr Tyr Thr Met Lys Glu Val Leu Phe Tyr Leu Gly 
    50                  55                  60                  


Gln Tyr Ile Met Thr Lys Arg Leu Tyr Asp Glu Lys Gln Gln His Ile 
65                  70                  75                  80  


Val Tyr Cys Ser Asn Asp Leu Leu Gly Asp Leu Phe Gly Val Pro Ser 
                85                  90                  95      


Phe Ser Val Lys Glu His Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn 
            100                 105                 110         


Leu Val Val Val Asn Gln Gln Glu Ser Ser Asp Ser Gly Thr Ser Val 
        115                 120                 125             


Ser Glu Asn Arg Cys His Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu 
    130                 135                 140                 


Val Gln Glu Leu Gln Glu Glu Lys Pro Ser Ser Ser His Leu Val Ser 
145                 150                 155                 160 


Arg Pro Ser Thr Ser Ser Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu 
                165                 170                 175     


Asn Ser Asp Glu Leu Ser Gly Glu Arg Gln Arg Lys Arg His Lys Ser 
            180                 185                 190         


Asp Ser Ile Ser Leu Ser Phe Asp Glu Ser Leu Ala Leu Cys Val Ile 
        195                 200                 205             


Arg Glu Ile Cys Cys Glu Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr 
    210                 215                 220                 


Pro Ser Asn Pro Asp Leu Asp Ala Gly Val Ser Glu His Ser Gly Asp 
225                 230                 235                 240 


Trp Leu Asp Gln Asp Ser Val Ser Asp Gln Phe Ser Val Glu Phe Glu 
                245                 250                 255     


Val Glu Ser Leu Asp Ser Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln 
            260                 265                 270         


Glu Leu Ser Asp Glu Asp Asp Glu Val Tyr Gln Val Thr Val Tyr Gln 
        275                 280                 285             


Ala Gly Glu Ser Asp Thr Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser 
    290                 295                 300                 


Leu Ala Asp Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn Pro Pro 
305                 310                 315                 320 


Leu Pro Ser His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu 
                325                 330                 335     


Pro Glu Asp Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys 
            340                 345                 350         


Leu Glu Asn Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro Asp Cys 
        355                 360                 365             


Lys Lys Thr Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu Glu Asn 
    370                 375                 380                 


Asp Asp Lys Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr 
385                 390                 395                 400 


Ser Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp 
                405                 410                 415     


Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu Ser Val 
            420                 425                 430         


Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln 
        435                 440                 445             


Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu 
    450                 455                 460                 


Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro 
465                 470                 475                 480 


Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe 
                485                 490                 495     


Pro 
    


<210>  7
<211>  1026
<212>  DNA
<213>  Homo sapiens

<400>  7
atggaggagc cgcagtcaga tcctagcgtc gagccccctc tgagtcagga aacattttca       60

gacctatgga aactacttcc tgaaaacaac gttctgtccc ccttgccgtc ccaagcaatg      120

gatgatttga tgctgtcccc ggacgatatt gaacaatggt tcactgaaga cccaggtcca      180

gatgaagctc ccagaatgcc agaggctgct ccccccgtgg cccctgcacc agcagctcct      240

acaccggcgg cccctgcacc agccccctcc tggcccctgt catcttctgt cccttcccag      300

aaaacctacc agggcagcta cggtttccgt ctgggcttct tgcattctgg gacagccaag      360

tctgtgactt gcacgtactc ccctgccctc aacaagatgt tttgccaact ggccaagacc      420

tgccctgtgc agctgtgggt tgattccaca cccccgcccg gcacccgcgt ccgcgccatg      480

gccatctaca agcagtcaca gcacatgacg gaggttgtga ggcgctgccc ccaccatgag      540

cgctgctcag atagcgatgg tctggcccct cctcagcatc ttatccgagt ggaaggaaat      600

ttgcgtgtgg agtatttgga tgacagaaac acttttcgac atagtgtggt ggtgccctat      660

gagccgcctg aggttggctc tgactgtacc accatccact acaactacat gtgtaacagt      720

tcctgcatgg gcggcatgaa ccggaggccc atcctcacca tcatcacact ggaagactcc      780

agtggtaatc tactgggacg gaacagcttt gaggtgcgtg tttgtgcctg tcctgggaga      840

gaccggcgca cagaggaaga gaatctccgc aagaaagggg agcctcacca cgagctgccc      900

ccagggagca ctaagcgagc actgcccaac aacaccagct cctctcccca gccaaagaag      960

aaaccactgg atggagaata tttcaccctt caggaccaga ccagctttca aaaagaaaat     1020

tgttaa                                                                1026


<210>  8
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe 
                325                 330                 335     


Gln Lys Glu Asn Cys 
            340     


