                         SEQUENCE LISTING

<110>  Garvan Institute of Medical Research
 
<120>  Methods of modulating immune response

<130>  184249PCT

<150>  AU 2019900574
<151>  2019-02-22

<150>  AU 2019900607
<151>  2019-02-26

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A20 reference protein sequence

<400>  1

Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu Val Thr Leu Lys Asp Ser Gly Pro Glu Ile Arg Ala 
            260                 265                 270         


Val Pro Leu Val Asn Arg Asp Arg Gly Arg Phe Glu Asp Leu Lys Val 
        275                 280                 285             


His Phe Leu Thr Asp Pro Glu Asn Glu Met Lys Glu Lys Leu Leu Lys 
    290                 295                 300                 


Glu Tyr Leu Met Val Ile Glu Ile Pro Val Gln Gly Trp Asp His Gly 
305                 310                 315                 320 


Thr Thr His Leu Ile Asn Ala Ala Lys Leu Asp Glu Ala Asn Leu Pro 
                325                 330                 335     


Lys Glu Ile Asn Leu Val Asp Asp Tyr Phe Glu Leu Val Gln His Glu 
            340                 345                 350         


Tyr Lys Lys Trp Gln Glu Asn Ser Glu Gln Gly Arg Arg Glu Gly His 
        355                 360                 365             


Ala Gln Asn Pro Met Glu Pro Ser Val Pro Gln Leu Ser Leu Met Asp 
    370                 375                 380                 


Val Lys Cys Glu Thr Pro Asn Cys Pro Phe Phe Met Ser Val Asn Thr 
385                 390                 395                 400 


Gln Pro Leu Cys His Glu Cys Ser Glu Arg Arg Gln Lys Asn Gln Asn 
                405                 410                 415     


Lys Leu Pro Lys Leu Asn Ser Lys Pro Gly Pro Glu Gly Leu Pro Gly 
            420                 425                 430         


Met Ala Leu Gly Ala Ser Arg Gly Glu Ala Tyr Glu Pro Leu Ala Trp 
        435                 440                 445             


Asn Pro Glu Glu Ser Thr Gly Gly Pro His Ser Ala Pro Pro Thr Ala 
    450                 455                 460                 


Pro Ser Pro Phe Leu Phe Ser Glu Thr Thr Ala Met Lys Cys Arg Ser 
465                 470                 475                 480 


Pro Gly Cys Pro Phe Thr Leu Asn Val Gln His Asn Gly Phe Cys Glu 
                485                 490                 495     


Arg Cys His Asn Ala Arg Gln Leu His Ala Ser His Ala Pro Asp His 
            500                 505                 510         


Thr Arg His Leu Asp Pro Gly Lys Cys Gln Ala Cys Leu Gln Asp Val 
        515                 520                 525             


Thr Arg Thr Phe Asn Gly Ile Cys Ser Thr Cys Phe Lys Arg Thr Thr 
    530                 535                 540                 


Ala Glu Ala Ser Ser Ser Leu Ser Thr Ser Leu Pro Pro Ser Cys His 
545                 550                 555                 560 


Gln Arg Ser Lys Ser Asp Pro Ser Arg Leu Val Arg Ser Pro Ser Pro 
                565                 570                 575     


His Ser Cys His Arg Ala Gly Asn Asp Ala Pro Ala Gly Cys Leu Ser 
            580                 585                 590         


Gln Ala Ala Arg Thr Pro Gly Asp Arg Thr Gly Thr Ser Lys Cys Arg 
        595                 600                 605             


Lys Ala Gly Cys Val Tyr Phe Gly Thr Pro Glu Asn Lys Gly Phe Cys 
    610                 615                 620                 


Thr Leu Cys Phe Ile Glu Tyr Arg Glu Asn Lys His Phe Ala Ala Ala 
625                 630                 635                 640 


Ser Gly Lys Val Ser Pro Thr Ala Ser Arg Phe Gln Asn Thr Ile Pro 
                645                 650                 655     


Cys Leu Gly Arg Glu Cys Gly Thr Leu Gly Ser Thr Met Phe Glu Gly 
            660                 665                 670         


Tyr Cys Gln Lys Cys Phe Ile Glu Ala Gln Asn Gln Arg Phe His Glu 
        675                 680                 685             


Ala Lys Arg Thr Glu Glu Gln Leu Arg Ser Ser Gln Arg Arg Asp Val 
    690                 695                 700                 


Pro Arg Thr Thr Gln Ser Thr Ser Arg Pro Lys Cys Ala Arg Ala Ser 
705                 710                 715                 720 


Cys Lys Asn Ile Leu Ala Cys Arg Ser Glu Glu Leu Cys Met Glu Cys 
                725                 730                 735     


Gln His Pro Asn Gln Arg Met Gly Pro Gly Ala His Arg Gly Glu Pro 
            740                 745                 750         


Ala Pro Glu Asp Pro Pro Lys Gln Arg Cys Arg Ala Pro Ala Cys Asp 
        755                 760                 765             


His Phe Gly Asn Ala Lys Cys Asn Gly Tyr Cys Asn Glu Cys Phe Gln 
    770                 775                 780                 


Phe Lys Gln Met Tyr Gly 
785                 790 


<210>  2
<211>  4735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A20 reference cDNA sequence

<400>  2
ctttggaaag tcccgtggaa atccccgggc ctacaacccg catacaactg aaacggggca       60

aagcagactg cgcagtctgc agtcttcgtg gcgggccaag cgagcttgga gcccgcgggg      120

gcggagcggt gagagcggcc gccaagagag atcacacccc cagccgaccc tgccagcgag      180

cgagcccgac cccaggcgtc catggagcgt cgcctccgcc cggtccctgc cccgaccccc      240

gcctgcggcg cgctcctgcc ttgaccagga cttgggactt tgcgaaagga tcgcggggcc      300

cggagaggta accgccgcgc ctcccggaga ggtaaccgcc gcgcctcccg gagaggtgtt      360

ggagagcaca atggctgaac aagtccttcc tcaggctttg tatttgagca atatgcggaa      420

agctgtgaag atacgggaga gaactccaga agacattttt aaacctacta atgggatcat      480

tcatcatttt aaaaccatgc accgatacac actggaaatg ttcagaactt gccagttttg      540

tcctcagttt cgggagatca tccacaaagc cctcatcgac agaaacatcc aggccaccct      600

ggaaagccag aagaaactca actggtgtcg agaagtccgg aagcttgtgg cgctgaaaac      660

gaacggtgac ggcaattgcc tcatgcatgc cacttctcag tacatgtggg gcgttcagga      720

cacagacttg gtactgagga aggcgctgtt cagcacgctc aaggaaacag acacacgcaa      780

ctttaaattc cgctggcaac tggagtctct caaatctcag gaatttgttg aaacggggct      840

ttgctatgat actcggaact ggaatgatga atgggacaat cttatcaaaa tggcttccac      900

agacacaccc atggcccgaa gtggacttca gtacaactca ctggaagaaa tacacatatt      960

tgtcctttgc aacatcctca gaaggccaat cattgtcatt tcagacaaaa tgctaagaag     1020

tttggaatca ggttccaatt tcgccccttt gaaagtgggt ggaatttact tgcctctcca     1080

ctggcctgcc caggaatgct acagataccc cattgttctc ggctatgaca gccatcattt     1140

tgtacccttg gtgaccctga aggacagtgg gcctgaaatc cgagctgttc cacttgttaa     1200

cagagaccgg ggaagatttg aagacttaaa agttcacttt ttgacagatc ctgaaaatga     1260

gatgaaggag aagctcttaa aagagtactt aatggtgata gaaatccccg tccaaggctg     1320

ggaccatggc acaactcatc tcatcaatgc cgcaaagttg gatgaagcta acttaccaaa     1380

agaaatcaat ctggtagatg attactttga acttgttcag catgagtaca agaaatggca     1440

ggaaaacagc gagcagggga ggagagaggg gcacgcccag aatcccatgg aaccttccgt     1500

gccccagctt tctctcatgg atgtaaaatg tgaaacgccc aactgcccct tcttcatgtc     1560

tgtgaacacc cagcctttat gccatgagtg ctcagagagg cggcaaaaga atcaaaacaa     1620

actcccaaag ctgaactcca agccgggccc tgaggggctc cctggcatgg cgctcggggc     1680

ctctcgggga gaagcctatg agcccttggc gtggaaccct gaggagtcca ctggggggcc     1740

tcattcggcc ccaccgacag cacccagccc ttttctgttc agtgagacca ctgccatgaa     1800

gtgcaggagc cccggctgcc ccttcacact gaatgtgcag cacaacggat tttgtgaacg     1860

ttgccacaac gcccggcaac ttcacgccag ccacgcccca gaccacacaa ggcacttgga     1920

tcccgggaag tgccaagcct gcctccagga tgttaccagg acatttaatg ggatctgcag     1980

tacttgcttc aaaaggacta cagcagaggc ctcctccagc ctcagcacca gcctccctcc     2040

ttcctgtcac cagcgttcca agtcagatcc ctcgcggctc gtccggagcc cctccccgca     2100

ttcttgccac agagctggaa acgacgcccc tgctggctgc ctgtctcaag ctgcacggac     2160

tcctggggac aggacgggga cgagcaagtg cagaaaagcc ggctgcgtgt attttgggac     2220

tccagaaaac aagggctttt gcacactgtg tttcatcgag tacagagaaa acaaacattt     2280

tgctgctgcc tcagggaaag tcagtcccac agcgtccagg ttccagaaca ccattccgtg     2340

cctggggagg gaatgcggca cccttggaag caccatgttt gaaggatact gccagaagtg     2400

tttcattgaa gctcagaatc agagatttca tgaggccaaa aggacagaag agcaactgag     2460

atcgagccag cgcagagatg tgcctcgaac cacacaaagc acctcaaggc ccaagtgcgc     2520

ccgggcctcc tgcaagaaca tcctggcctg ccgcagcgag gagctctgca tggagtgtca     2580

gcatcccaac cagaggatgg gccctggggc ccaccggggt gagcctgccc ccgaagaccc     2640

ccccaagcag cgttgccggg cccccgcctg tgatcatttt ggcaatgcca agtgcaacgg     2700

ctactgcaac gaatgctttc agttcaagca gatgtatggc taaccggaaa caggtgggtc     2760

acctcctgca agaagtgggg cctcgagctg tcagtcatca tggtgctatc ctctgaaccc     2820

ctcagctgcc actgcaacag tgggcttaag ggtgtctgag caggagagga aagataagct     2880

cttcgtggtg cccacgatgc tcaggtttgg taacccggga gtgttcccag gtggccttag     2940

aaagcaaagc ttgtaactgg caagggatga tgtcagattc agcccaaggt tcctcctctc     3000

ctaccaagca ggaggccagg aacttctttg gacttggaag gtgtgcgggg actggccgag     3060

gcccctgcac cctgcgcatc aggactgctt catcgtcttg gctgagaaag ggaaaagaca     3120

cacaagtcgc gtgggttgga gaagccagag ccattccacc tcccctcccc cagcatctct     3180

cagagatgtg aagccagatc ctcatggcag cgaggccctc tgcaagaagc tcaaggaagc     3240

tcagggaaaa tggacgtatt cagagagtgt ttgtagttca tggtttttcc ctacctgccc     3300

ggttcctttc ctgaggaccc ggcagaaatg cagaaccatc catggactgt gattctgagg     3360

ctgctgagac tgaacatgtt cacattgaca gaaaaacaag ctgctcttta taatatgcac     3420

cttttaaaaa attagaatat tttactggga agacgtgtaa ctctttgggt tattactgtc     3480

tttacttcta aagaagttag cttgaactga ggagtaaaag tgtgtacata tataatatac     3540

ccttacatta tgtatgaggg atttttttaa attatattga aatgctgccc tagaagtaca     3600

ataggaaggc taaataataa taacctgttt tctggttgtt gttggggcat gagcttgtgt     3660

atacactgct tgcataaact caaccagctg cctttttaaa gggagctcta gtcctttttg     3720

tgtaattcac tttatttatt ttattacaaa cttcaagatt atttaagtga agatatttct     3780

tcagctctgg ggaaaatgcc acagtgttct cctgagagaa catccttgct ttgagtcagg     3840

ctgtgggcaa gttcctgacc acagggagta aattggcctc tttgatacac ttttgcttgc     3900

ctccccagga aagaaggaat tgcatccaag gtatacatac atattcatcg atgtttcgtg     3960

cttctcctta tgaaactcca gctatgtaat aaaaaactat actctgtgtt ctgttaatgc     4020

ctctgagtgt cctacctcct tggagatgag atagggaagg agcagggatg agactggcaa     4080

tggtcacagg gaaagatgtg gccttttgtg atggttttat tttctgttaa cactgtgtcc     4140

tgggggggct gggaagtccc ctgcatccca tggtaccctg gtattgggac agcaaaagcc     4200

agtaaccatg agtatgagga aatctctttc tgttgctggc ttacagtttc tctgtgtgct     4260

ttgtggttgc tgtcatattt gctctagaag aaaaaaaaaa aaggagggga aatgcatttt     4320

ccccagagat aaaggctgcc attttggggg tctgtactta tggcctgaaa atatttgtga     4380

tccataactc tacacagcct ttactcatac tattaggcac actttcccct tagagccccc     4440

taagtttttc ccagacgaat ctttataatt tctttccaaa gataccaaat aaacttcagt     4500

gttttcatct aattctctta aagttgatat cttaatattt tgtgttgatc attatttcca     4560

ttcttaatgt gaaaaaaagt aattatttat acttattata aaaagtattt gaaatttgca     4620

catttaattg tccctaatag aaagccacct attctttgtt ggatttcttc aagtttttct     4680

aaataaatgt aacttttcac aagagtcaac attaaaaaat aaattattta agaac          4735


