                         SEQUENCE LISTING

<110>  INOVA DIAGNOSTICS, INC.
 
<120>  COMPOSITIONS AND METHODS FOR DIAGNOSING AND ASSESSING RHEUMATOID 
       ARTHRITIS

<130>  13510-034-228

<140>
<141>

<150>  US 62/806,607
<151>  2019-02-15

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  4361
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 2 (PADI2), mRNA

<400>  1
aggctgctgg agaaggcgca cctgctgcag gtgctcccgg ccgccccgga ccagcgagcg       60

cgggcactgc ggcggggagg atgctgcgcg agcggaccgt gcggctgcag tacgggagcc      120

gcgtggaggc ggtgtacgtg ctgggcacct acctctggac cgatgtctac agcgcggccc      180

cagccggggc ccaaaccttc agcctgaagc actcggaaca cgtgtgggtg gaggtggtgc      240

gtgatgggga ggctgaggag gtggccacca atggcaagca gcgctggctt ctctcgccca      300

gcaccaccct gcgggtcacc atgagccagg cgagcaccga ggccagcagt gacaaggtca      360

ccgtcaacta ctatgacgag gaagggagca ttcccatcga ccaggcgggg ctcttcctca      420

cagccattga gatctccctg gatgtggacg cagaccggga tggtgtggtg gagaagaaca      480

acccaaagaa ggcatcctgg acctggggcc ccgagggcca gggggccatc ctgctggtga      540

actgtgaccg agagacaccc tggttgccca aggaggactg ccgtgatgag aaggtctaca      600

gcaaggaaga tctcaaggac atgtcccaga tgatcctgcg gaccaaaggc cccgaccgcc      660

tccccgccgg atacgagata gttctgtaca tttccatgtc agactcagac aaagtgggcg      720

tgttctacgt ggagaacccg ttcttcggcc aacgctatat ccacatcctg ggccggcgga      780

agctctacca tgtggtcaag tacacgggtg gctccgcgga gctgctgttc ttcgtggaag      840

gcctctgttt ccccgacgag ggcttctcag gcctggtctc catccatgtc agcctgctgg      900

agtacatggc ccaggacatt cccctgactc ccatcttcac ggacaccgtg atattccgga      960

ttgctccgtg gatcatgacc cccaacatcc tgcctcccgt gtcggtgttt gtgtgctgca     1020

tgaaggataa ttacctgttc ctgaaagagg tgaagaacct tgtggagaaa accaactgtg     1080

agctgaaggt ctgcttccag tacctaaacc gaggcgatcg ctggatccag gatgaaattg     1140

agtttggcta catcgaggcc ccccataaag gcttccccgt ggtgctggac tctccccgag     1200

atggaaacct aaaggacttc cctgtgaagg agctcctggg cccagatttt ggctacgtga     1260

cccgggagcc cctctttgag tctgtcacca gccttgactc atttggaaac ctggaggtca     1320

gtcccccagt gaccgtgaac ggcaagacat acccgcttgg ccgcatcctc atcgggagca     1380

gctttcctct gtctggtggt cggaggatga ccaaggtggt gcgtgacttc ctgaaggccc     1440

agcaggtgca ggcgcccgtg gagctctact cagactggct gactgtgggc cacgtggatg     1500

agttcatgtc ctttgtcccc atccccggca caaagaaatt cctgctactc atggccagca     1560

cctcggcctg ctacaagctc ttccgagaga agcagaagga cggccatgga gaggccatca     1620

tgttcaaagg cttgggtggg atgagcagca agcgaatcac catcaacaag attctgtcca     1680

acgagagcct tgtgcaggag aacctgtact tccagcgctg cctagactgg aaccgtgaca     1740

tcctcaagaa ggagctggga ctgacagagc aggacatcat tgacctgccc gctctgttca     1800

agatggacga ggaccaccgt gccagagcct tcttcccaaa catggtgaac atgatcgtgc     1860

tggacaagga cctgggcatc cccaagccat tcgggccaca ggttgaggag gaatgctgcc     1920

tggagatgca cgtgcgtggc ctcctggagc ccctgggcct cgaatgcacc ttcatcgacg     1980

acatttctgc ctaccacaaa tttctggggg aagtccactg tggcaccaac gtccgcagga     2040

agcccttcac cttcaagtgg tggcacatgg tgccctgacc tgccaggggc cctggcgttt     2100

gcctccttcg cttagttctc cagaccctcc ctcacacgcc cagagccttc tgctgacatg     2160

gactggacag ccccgctggg agacctttgg gacgtggggt ggaatttggg gtatctgtgc     2220

cttgccctcc ctgagagggg cctcagtgtc ctctgaagcc atccccagtg agcctcgact     2280

ctgtccctgc tgaaaatagc tgggccagtg tctctgtagc cctgacataa ggaacagaac     2340

acaacaaaac acagcaaacc atgtgcccaa actgctcccc aaagaatttt gagtctctaa     2400

tctgacactg aatgagggga gaagggaagg agattctggg attgccagtt cttccagcag     2460

ccatgctctg aaaatcaagg tagaatccat ggaaagggac cccaggaccc cgggacccta     2520

gacgtatctt gaactgccat cgtcatttca aatacatctc cctcagggtt tccaggtggc     2580

cacccccaat tattcattcc ttaccaacct ctcaaatcct cttggctttc tctctgcagt     2640

gtggacactg ttggctagtc ctccccactc cctgagggtc cagtaagtta gcttagaacc     2700

ttcctggaaa catttcatct gagcaggttt ccccacgtgt gggatgctcc ttttgcctca     2760

tctgtctcag ggatgcaggc tcccccgcat gcatggggat ttctccccag accagcatac     2820

ttgtgacctg agagttcaat gcgtaaagat gcccctggtc agccatatcc atcttctctt     2880

gcctggtcct tgattctctg gccgctccct gaccttcctc cttccactgc cttgactttc     2940

ttccttttta ttcctggtgc catctgtcca ggcagctaga caagaacttg ttcgccagca     3000

gccagattca ggccttccca ggggcataat aagtgaccag cccctcctct ccggacatca     3060

gatccaacac ataaggaccc tggcctaccc tccagcccaa cagccagttc tgggtcagct     3120

gccaacttag gggtggtttg attatcccat tgaaattcac cagtgccttt gccaaagacc     3180

ctctcatttg gacataccca gattcattcc ctggctccaa ctgaaaagac tcagtttcaa     3240

tcgttaaaag ttcctttagg gccagaagaa taaatgaatt ataatcccat tttgaagaac     3300

cgatttataa ccaatgaaaa ggttataatg taatttatat tcttggagga acaagatttt     3360

catttgggat tatttccttc aaccattcaa caaacatttg ttgtatgcca ctaagcgcca     3420

ggcacggcgt tgggctctgc aaacacagtg gttagtagca gtctggacct ggtccctact     3480

ggcatggaac ccatcactcc ccaacatgca aagcccacat ttaaaggcca gcctctgccc     3540

cttcagtgat gcgctcttta gaaatgccag tccactatat tcagaaatcc gcagggcaca     3600

aaacttccag caagtcactg ttgtggtgaa atgggcagtg ggggtggggg gtcttcttta     3660

aacaggcccc cttcccatct acctagccag tacccatcca atgagtcccc agagcctcca     3720

gaagctgttg tctcctctct ggggacagca gctcctgcct ttggaggcca aagccccaga     3780

tctctccagc cccagagctg aaaacaccaa gtgcctattt gagggtgtct gtctggagac     3840

ttagagtttg tcatgtgtgt gtgtgtgttt ggttaatgtg ggtttatggg ttttctttct     3900

tttttttctt ttttttttta gtctacatta gggggaagtg agcgcctccc atgtgcagac     3960

agtgtgtctt tatagatttt tctaaggctt tccccaatga tgtcggtaat ttctgatgtt     4020

tctgaagttc ccaggactca cacacccgtt cccatctcac ttgcccaccc agtgtgacaa     4080

ccctcggtgt ggatataccc ccgtggactc atggctcttc cccaccccca ctttctataa     4140

atgtaggcct agaatacgct tctctgttgc aaaactcagc taagttcctg cttccacctt     4200

gatgttgaaa tatcttatgt aagagggcag gggatgtcgt gaagatggca agaagaacac     4260

agtttcaaat ttctggaaaa gagcctgtgg tggagatcta aagatgttta gggaagagct     4320

cgactaaaga acaatgaaat aaatggtcca aggggaagtc a                         4361


<210>  2
<211>  665
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-2 [Homo sapiens]

<400>  2

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
1               5                   10                  15      


Ala Val Tyr Val Leu Gly Thr Tyr Leu Trp Thr Asp Val Tyr Ser Ala 
            20                  25                  30          


Ala Pro Ala Gly Ala Gln Thr Phe Ser Leu Lys His Ser Glu His Val 
        35                  40                  45              


Trp Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Ala Thr Asn 
    50                  55                  60                  


Gly Lys Gln Arg Trp Leu Leu Ser Pro Ser Thr Thr Leu Arg Val Thr 
65                  70                  75                  80  


Met Ser Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                85                  90                  95      


Tyr Tyr Asp Glu Glu Gly Ser Ile Pro Ile Asp Gln Ala Gly Leu Phe 
            100                 105                 110         


Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
        115                 120                 125             


Val Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
    130                 135                 140                 


Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Glu Thr Pro 
145                 150                 155                 160 


Trp Leu Pro Lys Glu Asp Cys Arg Asp Glu Lys Val Tyr Ser Lys Glu 
                165                 170                 175     


Asp Leu Lys Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
            180                 185                 190         


Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
        195                 200                 205             


Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
    210                 215                 220                 


Arg Tyr Ile His Ile Leu Gly Arg Arg Lys Leu Tyr His Val Val Lys 
225                 230                 235                 240 


Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Cys 
                245                 250                 255     


Phe Pro Asp Glu Gly Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
            260                 265                 270         


Leu Glu Tyr Met Ala Gln Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
        275                 280                 285             


Thr Val Ile Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
    290                 295                 300                 


Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
305                 310                 315                 320 


Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                325                 330                 335     


Val Cys Phe Gln Tyr Leu Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
            340                 345                 350         


Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
        355                 360                 365             


Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Val Lys Glu 
    370                 375                 380                 


Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
385                 390                 395                 400 


Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                405                 410                 415     


Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
            420                 425                 430         


Ser Ser Phe Pro Leu Ser Gly Gly Arg Arg Met Thr Lys Val Val Arg 
        435                 440                 445             


Asp Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Thr Val Gly His Val Asp Glu Phe Met Ser Phe Val Pro 
465                 470                 475                 480 


Ile Pro Gly Thr Lys Lys Phe Leu Leu Leu Met Ala Ser Thr Ser Ala 
                485                 490                 495     


Cys Tyr Lys Leu Phe Arg Glu Lys Gln Lys Asp Gly His Gly Glu Ala 
            500                 505                 510         


Ile Met Phe Lys Gly Leu Gly Gly Met Ser Ser Lys Arg Ile Thr Ile 
        515                 520                 525             


Asn Lys Ile Leu Ser Asn Glu Ser Leu Val Gln Glu Asn Leu Tyr Phe 
    530                 535                 540                 


Gln Arg Cys Leu Asp Trp Asn Arg Asp Ile Leu Lys Lys Glu Leu Gly 
545                 550                 555                 560 


Leu Thr Glu Gln Asp Ile Ile Asp Leu Pro Ala Leu Phe Lys Met Asp 
                565                 570                 575     


Glu Asp His Arg Ala Arg Ala Phe Phe Pro Asn Met Val Asn Met Ile 
            580                 585                 590         


Val Leu Asp Lys Asp Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Val 
        595                 600                 605             


Glu Glu Glu Cys Cys Leu Glu Met His Val Arg Gly Leu Leu Glu Pro 
    610                 615                 620                 


Leu Gly Leu Glu Cys Thr Phe Ile Asp Asp Ile Ser Ala Tyr His Lys 
625                 630                 635                 640 


Phe Leu Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
                645                 650                 655     


Thr Phe Lys Trp Trp His Met Val Pro 
            660                 665 


<210>  3
<211>  3459
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 2 (PADI2), 
       transcript variant X2, mRNA

<400>  3
agcagctctg cagatgggga ttcttctgtc agctcatatc tgcacatgtg cacaaagaca       60

taaacataca agtgcactac agtgctgctt cttgtagtag caaaagattg caaagcaacc      120

taaatgtcca tctgtggagg actgagtaac ggccttcccg gaagttctgt gcaaccgcta      180

aaaaggatga agccagtctc tcaatatgga tacaggatgt gcttcaagga tgaaattgag      240

tttggctaca tcgaggcccc ccataaaggc ttccccgtgg tgctggactc tccccgagat      300

ggaaacctaa aggacttccc tgtgaaggag ctcctgggcc cagattttgg ctacgtgacc      360

cgggagcccc tctttgagtc tgtcaccagc cttgactcat ttggaaacct ggaggtcagt      420

cccccagtga ccgtgaacgg caagacatac ccgcttggcc gcatcctcat cgggagcagc      480

tttcctctgt ctggtggtcg gaggatgacc aaggtggtgc gtgacttcct gaaggcccag      540

caggtgcagg cgcccgtgga gctctactca gactggctga ctgtgggcca cgtggatgag      600

ttcatgtcct ttgtccccat ccccggcaca aagaaattcc tgctactcat ggccagcacc      660

tcggcctgct acaagctctt ccgagagaag cagaaggacg gccatggaga ggccatcatg      720

ttcaaaggct tgggtgggat gagcagcaag cgaatcacca tcaacaagat tctgtccaac      780

gagagccttg tgcaggagaa cctgtacttc cagcgctgcc tagactggaa ccgtgacatc      840

ctcaagaagg agctgggact gacagagcag gacatcattg acctgcccgc tctgttcaag      900

atggacgagg accaccgtgc cagagccttc ttcccaaaca tggtgaacat gatcgtgctg      960

gacaaggacc tgggcatccc caagccattc gggccacagg ttgaggagga atgctgcctg     1020

gagatgcacg tgcgtggcct cctggagccc ctgggcctcg aatgcacctt catcgacgac     1080

atttctgcct accacaaatt tctgggggaa gtccactgtg gcaccaacgt ccgcaggaag     1140

cccttcacct tcaagtggtg gcacatggtg ccctgacctg ccaggggccc tggcgtttgc     1200

ctccttcgct tagttctcca gaccctccct cacacgccca gagccttctg ctgacatgga     1260

ctggacagcc ccgctgggag acctttggga cgtggggtgg aatttggggt atctgtgcct     1320

tgccctccct gagaggggcc tcagtgtcct ctgaagccat ccccagtgag cctcgactct     1380

gtccctgctg aaaatagctg ggccagtgtc tctgtagccc tgacataagg aacagaacac     1440

aacaaaacac agcaaaccat gtgcccaaac tgctccccaa agaattttga gtctctaatc     1500

tgacactgaa tgaggggaga agggaaggag attctgggat tgccagttct tccagcagcc     1560

atgctctgaa aatcaaggta gaatccatgg aaagggaccc caggaccccg ggaccctaga     1620

cgtatcttga actgccatcg tcatttcaaa tacatctccc tcagggtttc caggtggcca     1680

cccccaatta ttcattcctt accaacctct caaatcctct tggctttctc tctgcagtgt     1740

ggacactgtt ggctagtcct ccccactccc tgagggtcca gtaagttagc ttagaacctt     1800

cctggaaaca tttcatctga gcaggtttcc ccacgtgtgg gatgctcctt ttgcctcatc     1860

tgtctcaggg atgcaggctc ccccgcatgc atggggattt ctccccagac cagcatactt     1920

gtgacctgag agttcaatgc gtaaagatgc ccctggtcag ccatatccat cttctcttgc     1980

ctggtccttg attctctggc cgctccctga ccttcctcct tccactgcct tgactttctt     2040

cctttttatt cctggtgcca tctgtccagg cagctagaca agaacttgtt cgccagcagc     2100

cagattcagg ccttcccagg ggcataataa gtgaccagcc cctcctctcc ggacatcaga     2160

tccaacacat aaggaccctg gcctaccctc cagcccaaca gccagttctg ggtcagctgc     2220

caacttaggg gtggtttgat tatcccattg aaattcacca gtgcctttgc caaagaccct     2280

ctcatttgga catacccaga ttcattccct ggctccaact gaaaagactc agtttcaatc     2340

gttaaaagtt cctttagggc cagaagaata aatgaattat aatcccattt tgaagaaccg     2400

atttataacc aatgaaaagg ttataatgta atttatattc ttggaggaac aagattttca     2460

tttgggatta tttccttcaa ccattcaaca aacatttgtt gtatgccact aagcgccagg     2520

cacggcgttg ggctctgcaa acacagtggt tagtagcagt ctggacctgg tccctactgg     2580

catggaaccc atcactcccc aacatgcaaa gcccacattt aaaggccagc ctctgcccct     2640

tcagtgatgc gctctttaga aatgccagtc cactatattc agaaatccgc agggcacaaa     2700

acttccagca agtcactgtt gtggtgaaat gggcagtggg ggtggggggt cttctttaaa     2760

caggccccct tcccatctac ctagccagta cccatccaat gagtccccag agcctccaga     2820

agctgttgtc tcctctctgg ggacagcagc tcctgccttt ggaggccaaa gccccagatc     2880

tctccagccc cagagctgaa aacaccaagt gcctatttga gggtgtctgt ctggagactt     2940

agagtttgtc atgtgtgtgt gtgtgtttgg ttaatgtggg tttatgggtt ttctttcttt     3000

tttttctttt tttttttagt ctacattagg gggaagtgag cgcctcccat gtgcagacag     3060

tgtgtcttta tagatttttc taaggctttc cccaatgatg tcggtaattt ctgatgtttc     3120

tgaagttccc aggactcaca cacccgttcc catctcactt gcccacccag tgtgacaacc     3180

ctcggtgtgg atataccccc gtggactcat ggctcttccc cacccccact ttctataaat     3240

gtaggcctag aatacgcttc tctgttgcaa aactcagcta agttcctgct tccaccttga     3300

tgttgaaata tcttatgtaa gagggcaggg gatgtcgtga agatggcaag aagaacacag     3360

tttcaaattt ctggaaaaga gcctgtggtg gagatctaaa gatgtttagg gaagagctcg     3420

actaaagaac aatgaaataa atggtccaag gggaagtca                            3459


<210>  4
<211>  350
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-2 isoform X1 [Homo sapiens]

<400>  4

Met Ser Ile Cys Gly Gly Leu Ser Asn Gly Leu Pro Gly Ser Ser Val 
1               5                   10                  15      


Gln Pro Leu Lys Arg Met Lys Pro Val Ser Gln Tyr Gly Tyr Arg Met 
            20                  25                  30          


Cys Phe Lys Asp Glu Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys 
        35                  40                  45              


Gly Phe Pro Val Val Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp 
    50                  55                  60                  


Phe Pro Val Lys Glu Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg 
65                  70                  75                  80  


Glu Pro Leu Phe Glu Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu 
                85                  90                  95      


Glu Val Ser Pro Pro Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly 
            100                 105                 110         


Arg Ile Leu Ile Gly Ser Ser Phe Pro Leu Ser Gly Gly Arg Arg Met 
        115                 120                 125             


Thr Lys Val Val Arg Asp Phe Leu Lys Ala Gln Gln Val Gln Ala Pro 
    130                 135                 140                 


Val Glu Leu Tyr Ser Asp Trp Leu Thr Val Gly His Val Asp Glu Phe 
145                 150                 155                 160 


Met Ser Phe Val Pro Ile Pro Gly Thr Lys Lys Phe Leu Leu Leu Met 
                165                 170                 175     


Ala Ser Thr Ser Ala Cys Tyr Lys Leu Phe Arg Glu Lys Gln Lys Asp 
            180                 185                 190         


Gly His Gly Glu Ala Ile Met Phe Lys Gly Leu Gly Gly Met Ser Ser 
        195                 200                 205             


Lys Arg Ile Thr Ile Asn Lys Ile Leu Ser Asn Glu Ser Leu Val Gln 
    210                 215                 220                 


Glu Asn Leu Tyr Phe Gln Arg Cys Leu Asp Trp Asn Arg Asp Ile Leu 
225                 230                 235                 240 


Lys Lys Glu Leu Gly Leu Thr Glu Gln Asp Ile Ile Asp Leu Pro Ala 
                245                 250                 255     


Leu Phe Lys Met Asp Glu Asp His Arg Ala Arg Ala Phe Phe Pro Asn 
            260                 265                 270         


Met Val Asn Met Ile Val Leu Asp Lys Asp Leu Gly Ile Pro Lys Pro 
        275                 280                 285             


Phe Gly Pro Gln Val Glu Glu Glu Cys Cys Leu Glu Met His Val Arg 
    290                 295                 300                 


Gly Leu Leu Glu Pro Leu Gly Leu Glu Cys Thr Phe Ile Asp Asp Ile 
305                 310                 315                 320 


Ser Ala Tyr His Lys Phe Leu Gly Glu Val His Cys Gly Thr Asn Val 
                325                 330                 335     


Arg Arg Lys Pro Phe Thr Phe Lys Trp Trp His Met Val Pro 
            340                 345                 350 


<210>  5
<211>  3189
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 3 (PADI3), mRNA

<400>  5
agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt       60

gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt      120

ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg      180

cgtggacatc tacatctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg      240

gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct      300

caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta      360

tgcggtgctc tacctcacct gtgttgacat ctctctggat tgcgacctga actgtgaggg      420

aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg      480

cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg      540

tgaccagcac gtgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac      600

gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga      660

tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag      720

gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga      780

gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt      840

ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga      900

cactgtggtg ttccgagtgg caccctggat catgacgccc agcactctgc cacccctaga      960

ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc     1020

caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg     1080

gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt     1140

ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc     1200

agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt     1260

tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag     1320

gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg     1380

ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc     1440

cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg     1500

gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg     1560

ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc     1620

catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg     1680

catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat     1740

tgacatccca cagctcttca agaccgagag gaaaaaagca acggccttct tccctgactt     1800

ggtgaacatg ctggtgctgg ggaagcacct gggcatcccc aagccctttg ggcccatcat     1860

caatggctgc tgctgcctgg aggagaaggt gcggtccctg ctggagccgc tgggcctcca     1920

ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg     1980

caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag     2040

ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga     2100

caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg     2160

accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg     2220

gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc     2280

tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg     2340

gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg     2400

tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca     2460

gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa     2520

agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca     2580

cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg     2640

agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg     2700

atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa     2760

gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca     2820

taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag     2880

aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct     2940

ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct     3000

gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg     3060

gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag     3120

ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag     3180

aaacacaaa                                                             3189


<210>  6
<211>  664
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 [Homo sapiens]

<400>  6

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  7
<211>  3189
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 3 (PADI3)transcript, 
       mRNA

<400>  7
agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt       60

gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt      120

ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg      180

cgtggacatc tacgtctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg      240

gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct      300

caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta      360

tgcggtgctc tacctcacct gtgttgacat ctctctggat tgcgacctga actgtgaggg      420

aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg      480

cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg      540

tgaccagcac gtgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac      600

gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga      660

tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag      720

gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga      780

gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt      840

ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga      900

cactgtggtg ttccgagtgg caccctggat catgacgccc agcactctgc cacccctaga      960

ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc     1020

caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg     1080

gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt     1140

ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc     1200

agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt     1260

tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag     1320

gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg     1380

ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc     1440

cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg     1500

gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg     1560

ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc     1620

catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg     1680

catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat     1740

tgacatccca cagctcttca agaccgagag gaaaaaagca acggccttct tccctgactt     1800

ggtgaacatg ctggtgctgg ggaagcacct gggcatcccc aagccctttg ggcccatcat     1860

caatggctgc tgctgcctgg aggagaaggt gcggtccctg ctggagccgc tgggcctcca     1920

ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg     1980

caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag     2040

ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga     2100

caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg     2160

accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg     2220

gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc     2280

tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg     2340

gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg     2400

tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca     2460

gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa     2520

agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca     2580

cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg     2640

agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg     2700

atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa     2760

gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca     2820

taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag     2880

aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct     2940

ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct     3000

gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg     3060

gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag     3120

ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag     3180

aaacacaaa                                                             3189


<210>  8
<211>  664
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 [Homo sapiens]

<400>  8

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Val Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  9
<211>  3189
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 3 (PADI3)transcript, 
       mRNA

<400>  9
agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt       60

gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt      120

ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg      180

cgtggacatc tacatctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg      240

gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct      300

caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta      360

tgcggtgctc taccacacct gtgttgacat ctctctggat tgcgacctga actgtgaggg      420

aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg      480

cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg      540

tgaccagcac gtgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac      600

gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga      660

tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag      720

gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga      780

gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt      840

ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga      900

cactgtggtg ttccgagtgg caccctggat catgacgccc agcactctgc cacccctaga      960

ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc     1020

caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg     1080

gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt     1140

ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc     1200

agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt     1260

tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag     1320

gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg     1380

ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc     1440

cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg     1500

gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg     1560

ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc     1620

catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg     1680

catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat     1740

tgacatccca cagctcttca agaccgagag gaaaaaagca acggccttct tccctgactt     1800

ggtgaacatg ctggtgctgg ggaagcacct gggcatcccc aagccctttg ggcccatcat     1860

caatggctgc tgctgcctgg aggagaaggt gcggtccctg ctggagccgc tgggcctcca     1920

ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg     1980

caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag     2040

ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga     2100

caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg     2160

accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg     2220

gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc     2280

tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg     2340

gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg     2400

tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca     2460

gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa     2520

agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca     2580

cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg     2640

agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg     2700

atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa     2760

gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca     2820

taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag     2880

aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct     2940

ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct     3000

gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg     3060

gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag     3120

ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag     3180

aaacacaaa                                                             3189


<210>  10
<211>  664
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 [Homo sapiens]

<400>  10

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr His 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  11
<211>  3189
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 3 (PADI3) transcript, 
       mRNA

<400>  11
agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt       60

gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt      120

ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg      180

cgtggacatc tacatctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg      240

gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct      300

caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta      360

tgcggtgctc tacctcacct gtgttgacat ctctctggat tgcgacctga actgtgaggg      420

aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg      480

cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg      540

tgaccagcac atgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac      600

gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga      660

tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag      720

gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga      780

gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt      840

ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga      900

cactgtggtg ttccgagtgg caccctggat catgacgccc agcactctgc cacccctaga      960

ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc     1020

caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg     1080

gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt     1140

ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc     1200

agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt     1260

tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag     1320

gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg     1380

ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc     1440

cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg     1500

gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg     1560

ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc     1620

catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg     1680

catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat     1740

tgacatccca cagctcttca agaccgagag gaaaaaagca acggccttct tccctgactt     1800

ggtgaacatg ctggtgctgg ggaagcacct gggcatcccc aagccctttg ggcccatcat     1860

caatggctgc tgctgcctgg aggagaaggt gcggtccctg ctggagccgc tgggcctcca     1920

ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg     1980

caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag     2040

ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga     2100

caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg     2160

accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg     2220

gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc     2280

tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg     2340

gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg     2400

tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca     2460

gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa     2520

agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca     2580

cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg     2640

agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg     2700

atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa     2760

gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca     2820

taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag     2880

aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct     2940

ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct     3000

gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg     3060

gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag     3120

ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag     3180

aaacacaaa                                                             3189


<210>  12
<211>  664
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 [Homo sapiens]

<400>  12

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Met His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  13
<211>  3189
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 3 (PADI3)transcript, 
       mRNA

<400>  13
agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt       60

gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt      120

ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg      180

cgtggacatc tacatctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg      240

gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct      300

caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta      360

tgcggtgctc tacctcacct gtgttgacat ctctctggat tgcgacctga actgtgaggg      420

aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg      480

cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg      540

tgaccagcac gtgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac      600

gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga      660

tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag      720

gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga      780

gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt      840

ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga      900

cactgtggtg ttccgagtgg taccctggat catgacgccc agcactctgc cacccctaga      960

ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc     1020

caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg     1080

gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt     1140

ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc     1200

agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt     1260

tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag     1320

gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg     1380

ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc     1440

cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg     1500

gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg     1560

ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc     1620

catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg     1680

catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat     1740

tgacatccca cagctcttca agaccgagag gaaaaaagca acggccttct tccctgactt     1800

ggtgaacatg ctggtgctgg ggaagcacct gggcatcccc aagccctttg ggcccatcat     1860

caatggctgc tgctgcctgg aggagaaggt gcggtccctg ctggagccgc tgggcctcca     1920

ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg     1980

caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag     2040

ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga     2100

caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg     2160

accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg     2220

gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc     2280

tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg     2340

gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg     2400

tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca     2460

gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa     2520

agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca     2580

cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg     2640

agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg     2700

atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa     2760

gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca     2820

taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag     2880

aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct     2940

ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct     3000

gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg     3060

gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag     3120

ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag     3180

aaacacaaa                                                             3189


<210>  14
<211>  664
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 [Homo sapiens]

<400>  14

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Val Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  15
<211>  3189
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 3 (PADI3) transcript, 
       mRNA

<400>  15
agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt       60

gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt      120

ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg      180

cgtggacatc tacatctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg      240

gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct      300

caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta      360

tgcggtgctc tacctcacct gtgttgacat ctctctggat tgcgacctga actgtgaggg      420

aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg      480

cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg      540

tgaccagcac gtgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac      600

gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga      660

tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag      720

gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga      780

gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt      840

ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga      900

cactgtggtg ttccgagtgg caccctggat catgacgccc agcactctgc cacccctaga      960

ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc     1020

caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg     1080

gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt     1140

ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc     1200

agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt     1260

tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag     1320

gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg     1380

ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc     1440

cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg     1500

gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg     1560

ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc     1620

catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg     1680

catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat     1740

tgacatccca cagctcttca agaccgagag gaaaaaaaca acggccttct tccctgactt     1800

ggtgaacatg ctggtgctgg ggaagcacct gggcatcccc aagccctttg ggcccatcat     1860

caatggctgc tgctgcctgg aggagaaggt gcggtccctg ctggagccgc tgggcctcca     1920

ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg     1980

caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag     2040

ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga     2100

caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg     2160

accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg     2220

gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc     2280

tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg     2340

gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg     2400

tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca     2460

gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa     2520

agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca     2580

cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg     2640

agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg     2700

atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa     2760

gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca     2820

taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag     2880

aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct     2940

ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct     3000

gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg     3060

gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag     3120

ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag     3180

aaacacaaa                                                             3189


<210>  16
<211>  664
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 [Homo sapiens]

<400>  16

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Thr Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  17
<211>  3189
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 3 (PADI3)transcript, 
       mRNA

<400>  17
agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt       60

gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt      120

ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg      180

cgtggacatc tacatctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg      240

gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct      300

caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta      360

tgcggtgctc tacctcacct gtgttgacat ctctctggat tgcgacctga actgtgaggg      420

aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg      480

cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg      540

tgaccagcac gtgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac      600

gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga      660

tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag      720

gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga      780

gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt      840

ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga      900

cactgtggtg ttccgagtgg caccctggat catgacgccc agcactctgc cacccctaga      960

ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc     1020

caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg     1080

gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt     1140

ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc     1200

agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt     1260

tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag     1320

gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg     1380

ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc     1440

cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg     1500

gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg     1560

ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc     1620

catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg     1680

catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat     1740

tgacatccca cagctcttca agaccgagag gaaaaaagca acggccttct tccctgactt     1800

ggtgaacatg ctggtgctgg ggaagcacct gggcataccc aagccctttg ggcccatcat     1860

caatggctgc tgctgcctgg aggagaaggt gcggtccctg ctggagccgc tgggcctcca     1920

ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg     1980

caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag     2040

ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga     2100

caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg     2160

accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg     2220

gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc     2280

tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg     2340

gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg     2400

tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca     2460

gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa     2520

agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca     2580

cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg     2640

agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg     2700

atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa     2760

gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca     2820

taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag     2880

aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct     2940

ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct     3000

gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg     3060

gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag     3120

ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag     3180

aaacacaaa                                                             3189


<210>  18
<211>  664
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 [Homo sapiens]

<400>  18

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Thr Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  19
<211>  3189
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 3 (PADI3)transcript, 
       mRNA

<400>  19
agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt       60

gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt      120

ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg      180

cgtggacatc tacatctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg      240

gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct      300

caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta      360

tgcggtgctc tacctcacct gtgttgacat ctctctggat tgcgacctga actgtgaggg      420

aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg      480

cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg      540

tgaccagcac gtgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac      600

gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga      660

tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag      720

gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga      780

gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt      840

ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga      900

cactgtggtg ttccgagtgg caccctggat catgacgccc agcactctgc cacccctaga      960

ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc     1020

caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg     1080

gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt     1140

ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc     1200

agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt     1260

tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag     1320

gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg     1380

ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc     1440

cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg     1500

gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg     1560

ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc     1620

catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg     1680

catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat     1740

tgacatccca cagctcttca agaccgagag gaaaaaagca acggccttct tccctgactt     1800

ggtgaacatg ctggtgctgg ggaagcacct gggcatcccc aagccctttg ggcccatcat     1860

caatggctgc tgctgcctgg aggagaaggt gcagtccctg ctggagccgc tgggcctcca     1920

ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg     1980

caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag     2040

ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga     2100

caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg     2160

accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg     2220

gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc     2280

tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg     2340

gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg     2400

tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca     2460

gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa     2520

agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca     2580

cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg     2640

agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg     2700

atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa     2760

gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca     2820

taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag     2880

aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct     2940

ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct     3000

gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg     3060

gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag     3120

ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag     3180

aaacacaaa                                                             3189


<210>  20
<211>  664
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 [Homo sapiens]

<400>  20

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Gln Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  21
<211>  4800
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X1, mRNA

<400>  21
tctccctggt tctgccattt cccctgtggg gggctgccca gggccaaaca ggccagaggg       60

ctccaccagc cctggaaatt acaggctttg ggagtagggt tgccagataa aataaaagat      120

gcctagttaa aattgaattt caggtaaata attaataatt tttttagtat aagtgtatcc      180

caaatacttc acgggagtac caaacaatga ttgactgttc acttgaaatt caagtccaac      240

tgagctttct gtatttttat ttgctaagtc tggcagccct gcttaggagg agaaacaggt      300

gtgtctgtcc ctcccaactg gtgaggacac ctgacagggg cccagacacc agagtgggac      360

ctgcctgatg gagagaagct tgggcttggt ttatttccct tttcataaaa aagctgcttt      420

gagatgtaag agaatcatgt tggtggaaga gtgaagaggt tgttttgggg gaggtctgcc      480

ttactctgag ggaagatggg aagcgggggg agtggccagc tgtggaaatt tggggtagtc      540

ccctacgtat cctgtgcctc agtttcccca tgtgtaaaca ggagtaatta tctcatcctg      600

gggctgcagt gaggatcaga tgagctaatg tacaaaaagg cttaggcagg cctgccgtga      660

taagagtgca gaggctgggg gctttttatg ttatggtatt gttgttatta ttactcctgg      720

ggaggtggtg ggcaagagtg tggactgagg agccacatgg ctgggtttgg atcccagccc      780

ggccacagac cttgggcaag ttacttaacc tcggctttct catctgtata atgggagaca      840

ataatagata gtgcctccct tctagggtta ttgagaggat tgcatgatgg gctggcacac      900

agcatgagct cagtaagtgt cagtcactgt tatcccccag gggcatgcat gccgctgcct      960

ccaggaggcc ctccaactcg cagtggcctc tccctacatg ggttcccact gagctgtgat     1020

cctgtggcct tgagccccat ctggctgccc tggacaatgt tggtcctcag ctccccagcg     1080

ggatcaacag tggggagagc agtgggtgga tctgcccgcc aggcagtacc tgagtgcaca     1140

gtgggcaccc cacagtcaaa ggatgcatag tctggtttcc aaggaggaac cccaggctag     1200

gtggaatgag ggaaatgcaa tctcagggcc agataacatc acagatactt taaacctgca     1260

attaatttct ggttgtttga ccaaatccgg ccaagtttcc cgggtgacac tgcagagctg     1320

tggaacagca tgggcttgga gtcagacctg ttgcacatct ggctctgcca tgtgatgcaa     1380

cctcaggctt gtcacgaggc ctccttgagc ctcagttgct aatatgccaa atggggatga     1440

tattgctcac cttacagctt gtaagagtgg agggagctgc gtgcgccagg tgcctggcat     1500

gcagcgggca ctcaaccaga ttgaattccc ttcccaggga agaattcaag gatatcttcc     1560

cacccactaa ggagacatgt gatgggatct ggggtgagaa ttgctctttt taaagctctc     1620

agaactgtaa ggggctccac ccaccaatgg ctggtgttca ctgagctctt cgtgcccaga     1680

cctgcactgg ggatttatcg agcacatggc tggcttctga cttccgaaga gctcgccatt     1740

ctggtcagtg cctgagggca cagaaatgtt tgaggtctat gggacgcctg gcgtggacat     1800

ctacatctct cccaacatgg agaggggccg ggagcgtgca gacaccaggc ggtggcgctt     1860

tgacgcgact ttggagatca tcgtggtcat gaactccccc agcaatgacc tcaacgacag     1920

ccatgttcag atttcctacc actccagcca tgagcctctg cccctggcct atgcggtgct     1980

ctacctcacc tgtgttgaca tctctctgga ttgcgacctg aactgtgagg gaaggcagga     2040

caggaacttt gtagacaagc ggcagtgggt ctgggggccc agtgggtatg gcggcatctt     2100

gctggtgaac tgtgaccgtg atgatccgag ctgtgatgtc caggacaatt gtgaccagca     2160

cgtgcactgc ctgcaagacc tggaagacat gtctgtcatg gtcctgcgga cgcagggccc     2220

tgcagccctc tttgatgacc acaaacttgt cctccatacc tccagctatg atgccaaacg     2280

ggcacaggtc ttccacatct gcggtcctga ggatgtgtgt gaggcctata ggcatgtgct     2340

gggccaagat aaggtgtcct atgaggtacc ccgcttgcat ggggatgagg agcgcttctt     2400

cgtggaaggc ctgtccttcc ctgatgccgg cttcacagga ctcatctcct tccatgtcac     2460

tctgctggac gactccaacg aggatttctc ggcatcccct atcttcactg acactgtggt     2520

gttccgagtg gcaccctgga tcatgacgcc cagcactctg ccacccctag aggtgtatgt     2580

gtgccgtgtg aggaacaaca cgtgttttgt ggatgcggtg gcagagctgg ccaggaaggc     2640

cggctgcaag ctgaccatct gcccacaggc cgagaaccgc aacgaccgct ggatccagga     2700

tgagatggag ctgggctacg ttcaggcgcc gcacaagacc ctcccggtgg tctttgactc     2760

cccaaggaat ggggaactgc aggatttccc ttacaaaaga atcctgggtc cagattttgg     2820

ttacgtgact cgggaaccac gcgacaggtc tgtgagtggc ctggactcct ttgggaacct     2880

ggaggtcagc cctccagtgg tggccaatgg gaaagagtac cccctgggga ggatcctcat     2940

tgggggcaac ctgcctgggt caagtggccg cagggtcacc caggtggtgc gggacttcct     3000

ccatgcccag aaggtgcagc cccccgtgga gctctttgtg gactggttgg ccgtgggcca     3060

tgtggatgag tttctgagct ttgtccctgc ccccgatggg aagggcttcc ggatgctcct     3120

ggccagccct ggggcctgct tcaagctctt ccaggaaaag cagaagtgtg gccacgggag     3180

ggccctcctg ttccaggggg ttgttgatga tgagcaggtc aagaccatct ccatcaacca     3240

ggtgctctcc aataaagacc tcatcaacta caataagttt gtgcagagct gcatcgactg     3300

gaaccgtgag gtgctgaagc gggagctggg cctggcagag tgtgacatca ttgacatccc     3360

acagctcttc aagaccgaga ggaaaaaagc aacggccttc ttccctgact tggtgaacat     3420

gctggtgctg gggaagcacc tgggcatccc caagcccttt gggcccatca tcaatggctg     3480

ctgctgcctg gaggagaagg tgcggtccct gctggagccg ctgggcctcc actgcacctt     3540

cattgatgac ttcactccat accacatgct gcatggggag gtgcactgtg gcaccaatgt     3600

gtgcagaaag cccttctctt tcaagtggtg gaacatggtg ccctgagaca gctcccaccc     3660

accatcctgt ccccctgggg cgggcattgg cccaggtggt ggagacagag acaggcccct     3720

gaacgataag caccaagaga ccccaaggct ccagatggaa cactgagggt gaccgtccct     3780

ctcagaagcc ttttccctgg aagtgtccat gcctcacctg caacccatgt ggttctcaga     3840

cttgaatctt ctcggccccc caaaaagaag gacctcattt cttatagcct ctcctgtgat     3900

tcaacacaac ccatggagat gtccccttct cactctgaaa tcatccattt ggggacaaat     3960

ccacattggg gtctagaaac atccacgtat ctcatcagcc atcttgtcct gtgcatccta     4020

acagaggaag gatccatgat tctgctttgg tccaattgct tcctctctgc agaggaacaa     4080

ccctaaaacc agaccactcc acgcaggaca ggcaggagag attcttccta aagcctcccc     4140

cataaaaagg gagctgtgga tccacttaga tcagggcgga accatctttc acccggccaa     4200

gctcctgccc agatgttgac cctcacccag cgtgagctgt cacatagtag gagcttctag     4260

atgcatgtgg aagcaatgag agttgtccct tagccttata aactccccat gatctgacat     4320

gcagaaatcc agccttgtcc agaatcctcc tggaatttct tggagacgaa agtatctggg     4380

ggattgttgg gtactaggga gactgggtac aagggtgaaa agtagttccc ataatacaca     4440

tggttgacta tggtgatcca ccttgtgatg gttaatatta ggtgtctgga gaaggttgct     4500

tcattggccc tgggacttct ctctgcagga ggagagaacg ctgcctctcc tctggattgg     4560

tctcaggctc tctgttggcc tttggtcagc gtttccacat cctgctctgc tgcaggagag     4620

ggggctaagg ggctggatcc accaaggcag ctcacagcgg gaaaactctg ggaatgaacc     4680

actgaattca ggggatgggg gtgggggggc ggttctcgag gtgtgtgcca gctacacgtg     4740

tgttctgtat gggtccagct gcgtttccat cactcgctaa taaatcaaca gaaacacaaa     4800


<210>  22
<211>  626
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X1 [Homo sapiens]

<400>  22

Met Phe Glu Val Tyr Gly Thr Pro Gly Val Asp Ile Tyr Ile Ser Pro 
1               5                   10                  15      


Asn Met Glu Arg Gly Arg Glu Arg Ala Asp Thr Arg Arg Trp Arg Phe 
            20                  25                  30          


Asp Ala Thr Leu Glu Ile Ile Val Val Met Asn Ser Pro Ser Asn Asp 
        35                  40                  45              


Leu Asn Asp Ser His Val Gln Ile Ser Tyr His Ser Ser His Glu Pro 
    50                  55                  60                  


Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu Thr Cys Val Asp Ile Ser 
65                  70                  75                  80  


Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg Gln Asp Arg Asn Phe Val 
                85                  90                  95      


Asp Lys Arg Gln Trp Val Trp Gly Pro Ser Gly Tyr Gly Gly Ile Leu 
            100                 105                 110         


Leu Val Asn Cys Asp Arg Asp Asp Pro Ser Cys Asp Val Gln Asp Asn 
        115                 120                 125             


Cys Asp Gln His Val His Cys Leu Gln Asp Leu Glu Asp Met Ser Val 
    130                 135                 140                 


Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp Asp His Lys 
145                 150                 155                 160 


Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala Gln Val Phe 
                165                 170                 175     


His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg His Val Leu 
            180                 185                 190         


Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His Gly Asp Glu 
        195                 200                 205             


Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala Gly Phe Thr 
    210                 215                 220                 


Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser Asn Glu Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe Arg Val Ala 
                245                 250                 255     


Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu Val Tyr Val 
            260                 265                 270         


Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val Ala Glu Leu 
        275                 280                 285             


Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln Ala Glu Asn 
    290                 295                 300                 


Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly Tyr Val Gln 
305                 310                 315                 320 


Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro Arg Asn Gly 
                325                 330                 335     


Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro Asp Phe Gly 
            340                 345                 350         


Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly Leu Asp Ser 
        355                 360                 365             


Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro Gly Ser Ser 
385                 390                 395                 400 


Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His Ala Gln Lys 
                405                 410                 415     


Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala Val Gly His 
            420                 425                 430         


Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly Lys Gly Phe 
        435                 440                 445             


Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu Phe Gln Glu 
    450                 455                 460                 


Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln Gly Val Val 
465                 470                 475                 480 


Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val Leu Ser Asn 
                485                 490                 495     


Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys Ile Asp Trp 
            500                 505                 510         


Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu Cys Asp Ile 
        515                 520                 525             


Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys Ala Thr Ala 
    530                 535                 540                 


Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys His Leu Gly 
545                 550                 555                 560 


Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys Cys Leu Glu 
                565                 570                 575     


Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His Cys Thr Phe 
            580                 585                 590         


Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu Val His Cys 
        595                 600                 605             


Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp Trp Asn Met 
    610                 615                 620                 


Val Pro 
625     


<210>  23
<211>  4800
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X1, mRNA

<400>  23
tctccctggt tctgccattt cccctgtggg gggctgccca gggccaaaca ggccagaggg       60

ctccaccagc cctggaaatt acaggctttg ggagtagggt tgccagataa aataaaagat      120

gcctagttaa aattgaattt caggtaaata attaataatt tttttagtat aagtgtatcc      180

caaatacttc acgggagtac caaacaatga ttgactgttc acttgaaatt caagtccaac      240

tgagctttct gtatttttat ttgctaagtc tggcagccct gcttaggagg agaaacaggt      300

gtgtctgtcc ctcccaactg gtgaggacac ctgacagggg cccagacacc agagtgggac      360

ctgcctgatg gagagaagct tgggcttggt ttatttccct tttcataaaa aagctgcttt      420

gagatgtaag agaatcatgt tggtggaaga gtgaagaggt tgttttgggg gaggtctgcc      480

ttactctgag ggaagatggg aagcgggggg agtggccagc tgtggaaatt tggggtagtc      540

ccctacgtat cctgtgcctc agtttcccca tgtgtaaaca ggagtaatta tctcatcctg      600

gggctgcagt gaggatcaga tgagctaatg tacaaaaagg cttaggcagg cctgccgtga      660

taagagtgca gaggctgggg gctttttatg ttatggtatt gttgttatta ttactcctgg      720

ggaggtggtg ggcaagagtg tggactgagg agccacatgg ctgggtttgg atcccagccc      780

ggccacagac cttgggcaag ttacttaacc tcggctttct catctgtata atgggagaca      840

ataatagata gtgcctccct tctagggtta ttgagaggat tgcatgatgg gctggcacac      900

agcatgagct cagtaagtgt cagtcactgt tatcccccag gggcatgcat gccgctgcct      960

ccaggaggcc ctccaactcg cagtggcctc tccctacatg ggttcccact gagctgtgat     1020

cctgtggcct tgagccccat ctggctgccc tggacaatgt tggtcctcag ctccccagcg     1080

ggatcaacag tggggagagc agtgggtgga tctgcccgcc aggcagtacc tgagtgcaca     1140

gtgggcaccc cacagtcaaa ggatgcatag tctggtttcc aaggaggaac cccaggctag     1200

gtggaatgag ggaaatgcaa tctcagggcc agataacatc acagatactt taaacctgca     1260

attaatttct ggttgtttga ccaaatccgg ccaagtttcc cgggtgacac tgcagagctg     1320

tggaacagca tgggcttgga gtcagacctg ttgcacatct ggctctgcca tgtgatgcaa     1380

cctcaggctt gtcacgaggc ctccttgagc ctcagttgct aatatgccaa atggggatga     1440

tattgctcac cttacagctt gtaagagtgg agggagctgc gtgcgccagg tgcctggcat     1500

gcagcgggca ctcaaccaga ttgaattccc ttcccaggga agaattcaag gatatcttcc     1560

cacccactaa ggagacatgt gatgggatct ggggtgagaa ttgctctttt taaagctctc     1620

agaactgtaa ggggctccac ccaccaatgg ctggtgttca ctgagctctt cgtgcccaga     1680

cctgcactgg ggatttatcg agcacatggc tggcttctga cttccgaaga gctcgccatt     1740

ctggtcagtg cctgagggca cagaaatgtt tgaggtctat gggacgcctg gcgtggacat     1800

ctacgtctct cccaacatgg agaggggccg ggagcgtgca gacaccaggc ggtggcgctt     1860

tgacgcgact ttggagatca tcgtggtcat gaactccccc agcaatgacc tcaacgacag     1920

ccatgttcag atttcctacc actccagcca tgagcctctg cccctggcct atgcggtgct     1980

ctacctcacc tgtgttgaca tctctctgga ttgcgacctg aactgtgagg gaaggcagga     2040

caggaacttt gtagacaagc ggcagtgggt ctgggggccc agtgggtatg gcggcatctt     2100

gctggtgaac tgtgaccgtg atgatccgag ctgtgatgtc caggacaatt gtgaccagca     2160

cgtgcactgc ctgcaagacc tggaagacat gtctgtcatg gtcctgcgga cgcagggccc     2220

tgcagccctc tttgatgacc acaaacttgt cctccatacc tccagctatg atgccaaacg     2280

ggcacaggtc ttccacatct gcggtcctga ggatgtgtgt gaggcctata ggcatgtgct     2340

gggccaagat aaggtgtcct atgaggtacc ccgcttgcat ggggatgagg agcgcttctt     2400

cgtggaaggc ctgtccttcc ctgatgccgg cttcacagga ctcatctcct tccatgtcac     2460

tctgctggac gactccaacg aggatttctc ggcatcccct atcttcactg acactgtggt     2520

gttccgagtg gcaccctgga tcatgacgcc cagcactctg ccacccctag aggtgtatgt     2580

gtgccgtgtg aggaacaaca cgtgttttgt ggatgcggtg gcagagctgg ccaggaaggc     2640

cggctgcaag ctgaccatct gcccacaggc cgagaaccgc aacgaccgct ggatccagga     2700

tgagatggag ctgggctacg ttcaggcgcc gcacaagacc ctcccggtgg tctttgactc     2760

cccaaggaat ggggaactgc aggatttccc ttacaaaaga atcctgggtc cagattttgg     2820

ttacgtgact cgggaaccac gcgacaggtc tgtgagtggc ctggactcct ttgggaacct     2880

ggaggtcagc cctccagtgg tggccaatgg gaaagagtac cccctgggga ggatcctcat     2940

tgggggcaac ctgcctgggt caagtggccg cagggtcacc caggtggtgc gggacttcct     3000

ccatgcccag aaggtgcagc cccccgtgga gctctttgtg gactggttgg ccgtgggcca     3060

tgtggatgag tttctgagct ttgtccctgc ccccgatggg aagggcttcc ggatgctcct     3120

ggccagccct ggggcctgct tcaagctctt ccaggaaaag cagaagtgtg gccacgggag     3180

ggccctcctg ttccaggggg ttgttgatga tgagcaggtc aagaccatct ccatcaacca     3240

ggtgctctcc aataaagacc tcatcaacta caataagttt gtgcagagct gcatcgactg     3300

gaaccgtgag gtgctgaagc gggagctggg cctggcagag tgtgacatca ttgacatccc     3360

acagctcttc aagaccgaga ggaaaaaagc aacggccttc ttccctgact tggtgaacat     3420

gctggtgctg gggaagcacc tgggcatccc caagcccttt gggcccatca tcaatggctg     3480

ctgctgcctg gaggagaagg tgcggtccct gctggagccg ctgggcctcc actgcacctt     3540

cattgatgac ttcactccat accacatgct gcatggggag gtgcactgtg gcaccaatgt     3600

gtgcagaaag cccttctctt tcaagtggtg gaacatggtg ccctgagaca gctcccaccc     3660

accatcctgt ccccctgggg cgggcattgg cccaggtggt ggagacagag acaggcccct     3720

gaacgataag caccaagaga ccccaaggct ccagatggaa cactgagggt gaccgtccct     3780

ctcagaagcc ttttccctgg aagtgtccat gcctcacctg caacccatgt ggttctcaga     3840

cttgaatctt ctcggccccc caaaaagaag gacctcattt cttatagcct ctcctgtgat     3900

tcaacacaac ccatggagat gtccccttct cactctgaaa tcatccattt ggggacaaat     3960

ccacattggg gtctagaaac atccacgtat ctcatcagcc atcttgtcct gtgcatccta     4020

acagaggaag gatccatgat tctgctttgg tccaattgct tcctctctgc agaggaacaa     4080

ccctaaaacc agaccactcc acgcaggaca ggcaggagag attcttccta aagcctcccc     4140

cataaaaagg gagctgtgga tccacttaga tcagggcgga accatctttc acccggccaa     4200

gctcctgccc agatgttgac cctcacccag cgtgagctgt cacatagtag gagcttctag     4260

atgcatgtgg aagcaatgag agttgtccct tagccttata aactccccat gatctgacat     4320

gcagaaatcc agccttgtcc agaatcctcc tggaatttct tggagacgaa agtatctggg     4380

ggattgttgg gtactaggga gactgggtac aagggtgaaa agtagttccc ataatacaca     4440

tggttgacta tggtgatcca ccttgtgatg gttaatatta ggtgtctgga gaaggttgct     4500

tcattggccc tgggacttct ctctgcagga ggagagaacg ctgcctctcc tctggattgg     4560

tctcaggctc tctgttggcc tttggtcagc gtttccacat cctgctctgc tgcaggagag     4620

ggggctaagg ggctggatcc accaaggcag ctcacagcgg gaaaactctg ggaatgaacc     4680

actgaattca ggggatgggg gtgggggggc ggttctcgag gtgtgtgcca gctacacgtg     4740

tgttctgtat gggtccagct gcgtttccat cactcgctaa taaatcaaca gaaacacaaa     4800


<210>  24
<211>  626
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X1 [Homo sapiens]

<400>  24

Met Phe Glu Val Tyr Gly Thr Pro Gly Val Asp Ile Tyr Val Ser Pro 
1               5                   10                  15      


Asn Met Glu Arg Gly Arg Glu Arg Ala Asp Thr Arg Arg Trp Arg Phe 
            20                  25                  30          


Asp Ala Thr Leu Glu Ile Ile Val Val Met Asn Ser Pro Ser Asn Asp 
        35                  40                  45              


Leu Asn Asp Ser His Val Gln Ile Ser Tyr His Ser Ser His Glu Pro 
    50                  55                  60                  


Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu Thr Cys Val Asp Ile Ser 
65                  70                  75                  80  


Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg Gln Asp Arg Asn Phe Val 
                85                  90                  95      


Asp Lys Arg Gln Trp Val Trp Gly Pro Ser Gly Tyr Gly Gly Ile Leu 
            100                 105                 110         


Leu Val Asn Cys Asp Arg Asp Asp Pro Ser Cys Asp Val Gln Asp Asn 
        115                 120                 125             


Cys Asp Gln His Val His Cys Leu Gln Asp Leu Glu Asp Met Ser Val 
    130                 135                 140                 


Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp Asp His Lys 
145                 150                 155                 160 


Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala Gln Val Phe 
                165                 170                 175     


His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg His Val Leu 
            180                 185                 190         


Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His Gly Asp Glu 
        195                 200                 205             


Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala Gly Phe Thr 
    210                 215                 220                 


Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser Asn Glu Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe Arg Val Ala 
                245                 250                 255     


Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu Val Tyr Val 
            260                 265                 270         


Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val Ala Glu Leu 
        275                 280                 285             


Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln Ala Glu Asn 
    290                 295                 300                 


Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly Tyr Val Gln 
305                 310                 315                 320 


Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro Arg Asn Gly 
                325                 330                 335     


Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro Asp Phe Gly 
            340                 345                 350         


Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly Leu Asp Ser 
        355                 360                 365             


Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro Gly Ser Ser 
385                 390                 395                 400 


Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His Ala Gln Lys 
                405                 410                 415     


Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala Val Gly His 
            420                 425                 430         


Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly Lys Gly Phe 
        435                 440                 445             


Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu Phe Gln Glu 
    450                 455                 460                 


Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln Gly Val Val 
465                 470                 475                 480 


Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val Leu Ser Asn 
                485                 490                 495     


Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys Ile Asp Trp 
            500                 505                 510         


Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu Cys Asp Ile 
        515                 520                 525             


Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys Ala Thr Ala 
    530                 535                 540                 


Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys His Leu Gly 
545                 550                 555                 560 


Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys Cys Leu Glu 
                565                 570                 575     


Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His Cys Thr Phe 
            580                 585                 590         


Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu Val His Cys 
        595                 600                 605             


Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp Trp Asn Met 
    610                 615                 620                 


Val Pro 
625     


<210>  25
<211>  4800
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X1, mRNA

<400>  25
tctccctggt tctgccattt cccctgtggg gggctgccca gggccaaaca ggccagaggg       60

ctccaccagc cctggaaatt acaggctttg ggagtagggt tgccagataa aataaaagat      120

gcctagttaa aattgaattt caggtaaata attaataatt tttttagtat aagtgtatcc      180

caaatacttc acgggagtac caaacaatga ttgactgttc acttgaaatt caagtccaac      240

tgagctttct gtatttttat ttgctaagtc tggcagccct gcttaggagg agaaacaggt      300

gtgtctgtcc ctcccaactg gtgaggacac ctgacagggg cccagacacc agagtgggac      360

ctgcctgatg gagagaagct tgggcttggt ttatttccct tttcataaaa aagctgcttt      420

gagatgtaag agaatcatgt tggtggaaga gtgaagaggt tgttttgggg gaggtctgcc      480

ttactctgag ggaagatggg aagcgggggg agtggccagc tgtggaaatt tggggtagtc      540

ccctacgtat cctgtgcctc agtttcccca tgtgtaaaca ggagtaatta tctcatcctg      600

gggctgcagt gaggatcaga tgagctaatg tacaaaaagg cttaggcagg cctgccgtga      660

taagagtgca gaggctgggg gctttttatg ttatggtatt gttgttatta ttactcctgg      720

ggaggtggtg ggcaagagtg tggactgagg agccacatgg ctgggtttgg atcccagccc      780

ggccacagac cttgggcaag ttacttaacc tcggctttct catctgtata atgggagaca      840

ataatagata gtgcctccct tctagggtta ttgagaggat tgcatgatgg gctggcacac      900

agcatgagct cagtaagtgt cagtcactgt tatcccccag gggcatgcat gccgctgcct      960

ccaggaggcc ctccaactcg cagtggcctc tccctacatg ggttcccact gagctgtgat     1020

cctgtggcct tgagccccat ctggctgccc tggacaatgt tggtcctcag ctccccagcg     1080

ggatcaacag tggggagagc agtgggtgga tctgcccgcc aggcagtacc tgagtgcaca     1140

gtgggcaccc cacagtcaaa ggatgcatag tctggtttcc aaggaggaac cccaggctag     1200

gtggaatgag ggaaatgcaa tctcagggcc agataacatc acagatactt taaacctgca     1260

attaatttct ggttgtttga ccaaatccgg ccaagtttcc cgggtgacac tgcagagctg     1320

tggaacagca tgggcttgga gtcagacctg ttgcacatct ggctctgcca tgtgatgcaa     1380

cctcaggctt gtcacgaggc ctccttgagc ctcagttgct aatatgccaa atggggatga     1440

tattgctcac cttacagctt gtaagagtgg agggagctgc gtgcgccagg tgcctggcat     1500

gcagcgggca ctcaaccaga ttgaattccc ttcccaggga agaattcaag gatatcttcc     1560

cacccactaa ggagacatgt gatgggatct ggggtgagaa ttgctctttt taaagctctc     1620

agaactgtaa ggggctccac ccaccaatgg ctggtgttca ctgagctctt cgtgcccaga     1680

cctgcactgg ggatttatcg agcacatggc tggcttctga cttccgaaga gctcgccatt     1740

ctggtcagtg cctgagggca cagaaatgtt tgaggtctat gggacgcctg gcgtggacat     1800

ctacatctct cccaacatgg agaggggccg ggagcgtgca gacaccaggc ggtggcgctt     1860

tgacgcgact ttggagatca tcgtggtcat gaactccccc agcaatgacc tcaacgacag     1920

ccatgttcag atttcctacc actccagcca tgagcctctg cccctggcct atgcggtgct     1980

ctaccacacc tgtgttgaca tctctctgga ttgcgacctg aactgtgagg gaaggcagga     2040

caggaacttt gtagacaagc ggcagtgggt ctgggggccc agtgggtatg gcggcatctt     2100

gctggtgaac tgtgaccgtg atgatccgag ctgtgatgtc caggacaatt gtgaccagca     2160

cgtgcactgc ctgcaagacc tggaagacat gtctgtcatg gtcctgcgga cgcagggccc     2220

tgcagccctc tttgatgacc acaaacttgt cctccatacc tccagctatg atgccaaacg     2280

ggcacaggtc ttccacatct gcggtcctga ggatgtgtgt gaggcctata ggcatgtgct     2340

gggccaagat aaggtgtcct atgaggtacc ccgcttgcat ggggatgagg agcgcttctt     2400

cgtggaaggc ctgtccttcc ctgatgccgg cttcacagga ctcatctcct tccatgtcac     2460

tctgctggac gactccaacg aggatttctc ggcatcccct atcttcactg acactgtggt     2520

gttccgagtg gcaccctgga tcatgacgcc cagcactctg ccacccctag aggtgtatgt     2580

gtgccgtgtg aggaacaaca cgtgttttgt ggatgcggtg gcagagctgg ccaggaaggc     2640

cggctgcaag ctgaccatct gcccacaggc cgagaaccgc aacgaccgct ggatccagga     2700

tgagatggag ctgggctacg ttcaggcgcc gcacaagacc ctcccggtgg tctttgactc     2760

cccaaggaat ggggaactgc aggatttccc ttacaaaaga atcctgggtc cagattttgg     2820

ttacgtgact cgggaaccac gcgacaggtc tgtgagtggc ctggactcct ttgggaacct     2880

ggaggtcagc cctccagtgg tggccaatgg gaaagagtac cccctgggga ggatcctcat     2940

tgggggcaac ctgcctgggt caagtggccg cagggtcacc caggtggtgc gggacttcct     3000

ccatgcccag aaggtgcagc cccccgtgga gctctttgtg gactggttgg ccgtgggcca     3060

tgtggatgag tttctgagct ttgtccctgc ccccgatggg aagggcttcc ggatgctcct     3120

ggccagccct ggggcctgct tcaagctctt ccaggaaaag cagaagtgtg gccacgggag     3180

ggccctcctg ttccaggggg ttgttgatga tgagcaggtc aagaccatct ccatcaacca     3240

ggtgctctcc aataaagacc tcatcaacta caataagttt gtgcagagct gcatcgactg     3300

gaaccgtgag gtgctgaagc gggagctggg cctggcagag tgtgacatca ttgacatccc     3360

acagctcttc aagaccgaga ggaaaaaagc aacggccttc ttccctgact tggtgaacat     3420

gctggtgctg gggaagcacc tgggcatccc caagcccttt gggcccatca tcaatggctg     3480

ctgctgcctg gaggagaagg tgcggtccct gctggagccg ctgggcctcc actgcacctt     3540

cattgatgac ttcactccat accacatgct gcatggggag gtgcactgtg gcaccaatgt     3600

gtgcagaaag cccttctctt tcaagtggtg gaacatggtg ccctgagaca gctcccaccc     3660

accatcctgt ccccctgggg cgggcattgg cccaggtggt ggagacagag acaggcccct     3720

gaacgataag caccaagaga ccccaaggct ccagatggaa cactgagggt gaccgtccct     3780

ctcagaagcc ttttccctgg aagtgtccat gcctcacctg caacccatgt ggttctcaga     3840

cttgaatctt ctcggccccc caaaaagaag gacctcattt cttatagcct ctcctgtgat     3900

tcaacacaac ccatggagat gtccccttct cactctgaaa tcatccattt ggggacaaat     3960

ccacattggg gtctagaaac atccacgtat ctcatcagcc atcttgtcct gtgcatccta     4020

acagaggaag gatccatgat tctgctttgg tccaattgct tcctctctgc agaggaacaa     4080

ccctaaaacc agaccactcc acgcaggaca ggcaggagag attcttccta aagcctcccc     4140

cataaaaagg gagctgtgga tccacttaga tcagggcgga accatctttc acccggccaa     4200

gctcctgccc agatgttgac cctcacccag cgtgagctgt cacatagtag gagcttctag     4260

atgcatgtgg aagcaatgag agttgtccct tagccttata aactccccat gatctgacat     4320

gcagaaatcc agccttgtcc agaatcctcc tggaatttct tggagacgaa agtatctggg     4380

ggattgttgg gtactaggga gactgggtac aagggtgaaa agtagttccc ataatacaca     4440

tggttgacta tggtgatcca ccttgtgatg gttaatatta ggtgtctgga gaaggttgct     4500

tcattggccc tgggacttct ctctgcagga ggagagaacg ctgcctctcc tctggattgg     4560

tctcaggctc tctgttggcc tttggtcagc gtttccacat cctgctctgc tgcaggagag     4620

ggggctaagg ggctggatcc accaaggcag ctcacagcgg gaaaactctg ggaatgaacc     4680

actgaattca ggggatgggg gtgggggggc ggttctcgag gtgtgtgcca gctacacgtg     4740

tgttctgtat gggtccagct gcgtttccat cactcgctaa taaatcaaca gaaacacaaa     4800


<210>  26
<211>  626
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X1 [Homo sapiens]

<400>  26

Met Phe Glu Val Tyr Gly Thr Pro Gly Val Asp Ile Tyr Ile Ser Pro 
1               5                   10                  15      


Asn Met Glu Arg Gly Arg Glu Arg Ala Asp Thr Arg Arg Trp Arg Phe 
            20                  25                  30          


Asp Ala Thr Leu Glu Ile Ile Val Val Met Asn Ser Pro Ser Asn Asp 
        35                  40                  45              


Leu Asn Asp Ser His Val Gln Ile Ser Tyr His Ser Ser His Glu Pro 
    50                  55                  60                  


Leu Pro Leu Ala Tyr Ala Val Leu Tyr His Thr Cys Val Asp Ile Ser 
65                  70                  75                  80  


Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg Gln Asp Arg Asn Phe Val 
                85                  90                  95      


Asp Lys Arg Gln Trp Val Trp Gly Pro Ser Gly Tyr Gly Gly Ile Leu 
            100                 105                 110         


Leu Val Asn Cys Asp Arg Asp Asp Pro Ser Cys Asp Val Gln Asp Asn 
        115                 120                 125             


Cys Asp Gln His Val His Cys Leu Gln Asp Leu Glu Asp Met Ser Val 
    130                 135                 140                 


Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp Asp His Lys 
145                 150                 155                 160 


Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala Gln Val Phe 
                165                 170                 175     


His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg His Val Leu 
            180                 185                 190         


Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His Gly Asp Glu 
        195                 200                 205             


Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala Gly Phe Thr 
    210                 215                 220                 


Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser Asn Glu Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe Arg Val Ala 
                245                 250                 255     


Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu Val Tyr Val 
            260                 265                 270         


Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val Ala Glu Leu 
        275                 280                 285             


Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln Ala Glu Asn 
    290                 295                 300                 


Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly Tyr Val Gln 
305                 310                 315                 320 


Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro Arg Asn Gly 
                325                 330                 335     


Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro Asp Phe Gly 
            340                 345                 350         


Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly Leu Asp Ser 
        355                 360                 365             


Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro Gly Ser Ser 
385                 390                 395                 400 


Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His Ala Gln Lys 
                405                 410                 415     


Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala Val Gly His 
            420                 425                 430         


Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly Lys Gly Phe 
        435                 440                 445             


Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu Phe Gln Glu 
    450                 455                 460                 


Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln Gly Val Val 
465                 470                 475                 480 


Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val Leu Ser Asn 
                485                 490                 495     


Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys Ile Asp Trp 
            500                 505                 510         


Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu Cys Asp Ile 
        515                 520                 525             


Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys Ala Thr Ala 
    530                 535                 540                 


Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys His Leu Gly 
545                 550                 555                 560 


Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys Cys Leu Glu 
                565                 570                 575     


Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His Cys Thr Phe 
            580                 585                 590         


Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu Val His Cys 
        595                 600                 605             


Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp Trp Asn Met 
    610                 615                 620                 


Val Pro 
625     


<210>  27
<211>  4800
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X1, mRNA

<400>  27
tctccctggt tctgccattt cccctgtggg gggctgccca gggccaaaca ggccagaggg       60

ctccaccagc cctggaaatt acaggctttg ggagtagggt tgccagataa aataaaagat      120

gcctagttaa aattgaattt caggtaaata attaataatt tttttagtat aagtgtatcc      180

caaatacttc acgggagtac caaacaatga ttgactgttc acttgaaatt caagtccaac      240

tgagctttct gtatttttat ttgctaagtc tggcagccct gcttaggagg agaaacaggt      300

gtgtctgtcc ctcccaactg gtgaggacac ctgacagggg cccagacacc agagtgggac      360

ctgcctgatg gagagaagct tgggcttggt ttatttccct tttcataaaa aagctgcttt      420

gagatgtaag agaatcatgt tggtggaaga gtgaagaggt tgttttgggg gaggtctgcc      480

ttactctgag ggaagatggg aagcgggggg agtggccagc tgtggaaatt tggggtagtc      540

ccctacgtat cctgtgcctc agtttcccca tgtgtaaaca ggagtaatta tctcatcctg      600

gggctgcagt gaggatcaga tgagctaatg tacaaaaagg cttaggcagg cctgccgtga      660

taagagtgca gaggctgggg gctttttatg ttatggtatt gttgttatta ttactcctgg      720

ggaggtggtg ggcaagagtg tggactgagg agccacatgg ctgggtttgg atcccagccc      780

ggccacagac cttgggcaag ttacttaacc tcggctttct catctgtata atgggagaca      840

ataatagata gtgcctccct tctagggtta ttgagaggat tgcatgatgg gctggcacac      900

agcatgagct cagtaagtgt cagtcactgt tatcccccag gggcatgcat gccgctgcct      960

ccaggaggcc ctccaactcg cagtggcctc tccctacatg ggttcccact gagctgtgat     1020

cctgtggcct tgagccccat ctggctgccc tggacaatgt tggtcctcag ctccccagcg     1080

ggatcaacag tggggagagc agtgggtgga tctgcccgcc aggcagtacc tgagtgcaca     1140

gtgggcaccc cacagtcaaa ggatgcatag tctggtttcc aaggaggaac cccaggctag     1200

gtggaatgag ggaaatgcaa tctcagggcc agataacatc acagatactt taaacctgca     1260

attaatttct ggttgtttga ccaaatccgg ccaagtttcc cgggtgacac tgcagagctg     1320

tggaacagca tgggcttgga gtcagacctg ttgcacatct ggctctgcca tgtgatgcaa     1380

cctcaggctt gtcacgaggc ctccttgagc ctcagttgct aatatgccaa atggggatga     1440

tattgctcac cttacagctt gtaagagtgg agggagctgc gtgcgccagg tgcctggcat     1500

gcagcgggca ctcaaccaga ttgaattccc ttcccaggga agaattcaag gatatcttcc     1560

cacccactaa ggagacatgt gatgggatct ggggtgagaa ttgctctttt taaagctctc     1620

agaactgtaa ggggctccac ccaccaatgg ctggtgttca ctgagctctt cgtgcccaga     1680

cctgcactgg ggatttatcg agcacatggc tggcttctga cttccgaaga gctcgccatt     1740

ctggtcagtg cctgagggca cagaaatgtt tgaggtctat gggacgcctg gcgtggacat     1800

ctacatctct cccaacatgg agaggggccg ggagcgtgca gacaccaggc ggtggcgctt     1860

tgacgcgact ttggagatca tcgtggtcat gaactccccc agcaatgacc tcaacgacag     1920

ccatgttcag atttcctacc actccagcca tgagcctctg cccctggcct atgcggtgct     1980

ctacctcacc tgtgttgaca tctctctgga ttgcgacctg aactgtgagg gaaggcagga     2040

caggaacttt gtagacaagc ggcagtgggt ctgggggccc agtgggtatg gcggcatctt     2100

gctggtgaac tgtgaccgtg atgatccgag ctgtgatgtc caggacaatt gtgaccagca     2160

catgcactgc ctgcaagacc tggaagacat gtctgtcatg gtcctgcgga cgcagggccc     2220

tgcagccctc tttgatgacc acaaacttgt cctccatacc tccagctatg atgccaaacg     2280

ggcacaggtc ttccacatct gcggtcctga ggatgtgtgt gaggcctata ggcatgtgct     2340

gggccaagat aaggtgtcct atgaggtacc ccgcttgcat ggggatgagg agcgcttctt     2400

cgtggaaggc ctgtccttcc ctgatgccgg cttcacagga ctcatctcct tccatgtcac     2460

tctgctggac gactccaacg aggatttctc ggcatcccct atcttcactg acactgtggt     2520

gttccgagtg gcaccctgga tcatgacgcc cagcactctg ccacccctag aggtgtatgt     2580

gtgccgtgtg aggaacaaca cgtgttttgt ggatgcggtg gcagagctgg ccaggaaggc     2640

cggctgcaag ctgaccatct gcccacaggc cgagaaccgc aacgaccgct ggatccagga     2700

tgagatggag ctgggctacg ttcaggcgcc gcacaagacc ctcccggtgg tctttgactc     2760

cccaaggaat ggggaactgc aggatttccc ttacaaaaga atcctgggtc cagattttgg     2820

ttacgtgact cgggaaccac gcgacaggtc tgtgagtggc ctggactcct ttgggaacct     2880

ggaggtcagc cctccagtgg tggccaatgg gaaagagtac cccctgggga ggatcctcat     2940

tgggggcaac ctgcctgggt caagtggccg cagggtcacc caggtggtgc gggacttcct     3000

ccatgcccag aaggtgcagc cccccgtgga gctctttgtg gactggttgg ccgtgggcca     3060

tgtggatgag tttctgagct ttgtccctgc ccccgatggg aagggcttcc ggatgctcct     3120

ggccagccct ggggcctgct tcaagctctt ccaggaaaag cagaagtgtg gccacgggag     3180

ggccctcctg ttccaggggg ttgttgatga tgagcaggtc aagaccatct ccatcaacca     3240

ggtgctctcc aataaagacc tcatcaacta caataagttt gtgcagagct gcatcgactg     3300

gaaccgtgag gtgctgaagc gggagctggg cctggcagag tgtgacatca ttgacatccc     3360

acagctcttc aagaccgaga ggaaaaaagc aacggccttc ttccctgact tggtgaacat     3420

gctggtgctg gggaagcacc tgggcatccc caagcccttt gggcccatca tcaatggctg     3480

ctgctgcctg gaggagaagg tgcggtccct gctggagccg ctgggcctcc actgcacctt     3540

cattgatgac ttcactccat accacatgct gcatggggag gtgcactgtg gcaccaatgt     3600

gtgcagaaag cccttctctt tcaagtggtg gaacatggtg ccctgagaca gctcccaccc     3660

accatcctgt ccccctgggg cgggcattgg cccaggtggt ggagacagag acaggcccct     3720

gaacgataag caccaagaga ccccaaggct ccagatggaa cactgagggt gaccgtccct     3780

ctcagaagcc ttttccctgg aagtgtccat gcctcacctg caacccatgt ggttctcaga     3840

cttgaatctt ctcggccccc caaaaagaag gacctcattt cttatagcct ctcctgtgat     3900

tcaacacaac ccatggagat gtccccttct cactctgaaa tcatccattt ggggacaaat     3960

ccacattggg gtctagaaac atccacgtat ctcatcagcc atcttgtcct gtgcatccta     4020

acagaggaag gatccatgat tctgctttgg tccaattgct tcctctctgc agaggaacaa     4080

ccctaaaacc agaccactcc acgcaggaca ggcaggagag attcttccta aagcctcccc     4140

cataaaaagg gagctgtgga tccacttaga tcagggcgga accatctttc acccggccaa     4200

gctcctgccc agatgttgac cctcacccag cgtgagctgt cacatagtag gagcttctag     4260

atgcatgtgg aagcaatgag agttgtccct tagccttata aactccccat gatctgacat     4320

gcagaaatcc agccttgtcc agaatcctcc tggaatttct tggagacgaa agtatctggg     4380

ggattgttgg gtactaggga gactgggtac aagggtgaaa agtagttccc ataatacaca     4440

tggttgacta tggtgatcca ccttgtgatg gttaatatta ggtgtctgga gaaggttgct     4500

tcattggccc tgggacttct ctctgcagga ggagagaacg ctgcctctcc tctggattgg     4560

tctcaggctc tctgttggcc tttggtcagc gtttccacat cctgctctgc tgcaggagag     4620

ggggctaagg ggctggatcc accaaggcag ctcacagcgg gaaaactctg ggaatgaacc     4680

actgaattca ggggatgggg gtgggggggc ggttctcgag gtgtgtgcca gctacacgtg     4740

tgttctgtat gggtccagct gcgtttccat cactcgctaa taaatcaaca gaaacacaaa     4800


<210>  28
<211>  626
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X1 [Homo sapiens]

<400>  28

Met Phe Glu Val Tyr Gly Thr Pro Gly Val Asp Ile Tyr Ile Ser Pro 
1               5                   10                  15      


Asn Met Glu Arg Gly Arg Glu Arg Ala Asp Thr Arg Arg Trp Arg Phe 
            20                  25                  30          


Asp Ala Thr Leu Glu Ile Ile Val Val Met Asn Ser Pro Ser Asn Asp 
        35                  40                  45              


Leu Asn Asp Ser His Val Gln Ile Ser Tyr His Ser Ser His Glu Pro 
    50                  55                  60                  


Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu Thr Cys Val Asp Ile Ser 
65                  70                  75                  80  


Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg Gln Asp Arg Asn Phe Val 
                85                  90                  95      


Asp Lys Arg Gln Trp Val Trp Gly Pro Ser Gly Tyr Gly Gly Ile Leu 
            100                 105                 110         


Leu Val Asn Cys Asp Arg Asp Asp Pro Ser Cys Asp Val Gln Asp Asn 
        115                 120                 125             


Cys Asp Gln His Met His Cys Leu Gln Asp Leu Glu Asp Met Ser Val 
    130                 135                 140                 


Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp Asp His Lys 
145                 150                 155                 160 


Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala Gln Val Phe 
                165                 170                 175     


His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg His Val Leu 
            180                 185                 190         


Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His Gly Asp Glu 
        195                 200                 205             


Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala Gly Phe Thr 
    210                 215                 220                 


Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser Asn Glu Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe Arg Val Ala 
                245                 250                 255     


Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu Val Tyr Val 
            260                 265                 270         


Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val Ala Glu Leu 
        275                 280                 285             


Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln Ala Glu Asn 
    290                 295                 300                 


Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly Tyr Val Gln 
305                 310                 315                 320 


Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro Arg Asn Gly 
                325                 330                 335     


Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro Asp Phe Gly 
            340                 345                 350         


Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly Leu Asp Ser 
        355                 360                 365             


Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro Gly Ser Ser 
385                 390                 395                 400 


Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His Ala Gln Lys 
                405                 410                 415     


Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala Val Gly His 
            420                 425                 430         


Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly Lys Gly Phe 
        435                 440                 445             


Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu Phe Gln Glu 
    450                 455                 460                 


Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln Gly Val Val 
465                 470                 475                 480 


Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val Leu Ser Asn 
                485                 490                 495     


Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys Ile Asp Trp 
            500                 505                 510         


Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu Cys Asp Ile 
        515                 520                 525             


Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys Ala Thr Ala 
    530                 535                 540                 


Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys His Leu Gly 
545                 550                 555                 560 


Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys Cys Leu Glu 
                565                 570                 575     


Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His Cys Thr Phe 
            580                 585                 590         


Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu Val His Cys 
        595                 600                 605             


Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp Trp Asn Met 
    610                 615                 620                 


Val Pro 
625     


<210>  29
<211>  4800
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X1, mRNA

<400>  29
tctccctggt tctgccattt cccctgtggg gggctgccca gggccaaaca ggccagaggg       60

ctccaccagc cctggaaatt acaggctttg ggagtagggt tgccagataa aataaaagat      120

gcctagttaa aattgaattt caggtaaata attaataatt tttttagtat aagtgtatcc      180

caaatacttc acgggagtac caaacaatga ttgactgttc acttgaaatt caagtccaac      240

tgagctttct gtatttttat ttgctaagtc tggcagccct gcttaggagg agaaacaggt      300

gtgtctgtcc ctcccaactg gtgaggacac ctgacagggg cccagacacc agagtgggac      360

ctgcctgatg gagagaagct tgggcttggt ttatttccct tttcataaaa aagctgcttt      420

gagatgtaag agaatcatgt tggtggaaga gtgaagaggt tgttttgggg gaggtctgcc      480

ttactctgag ggaagatggg aagcgggggg agtggccagc tgtggaaatt tggggtagtc      540

ccctacgtat cctgtgcctc agtttcccca tgtgtaaaca ggagtaatta tctcatcctg      600

gggctgcagt gaggatcaga tgagctaatg tacaaaaagg cttaggcagg cctgccgtga      660

taagagtgca gaggctgggg gctttttatg ttatggtatt gttgttatta ttactcctgg      720

ggaggtggtg ggcaagagtg tggactgagg agccacatgg ctgggtttgg atcccagccc      780

ggccacagac cttgggcaag ttacttaacc tcggctttct catctgtata atgggagaca      840

ataatagata gtgcctccct tctagggtta ttgagaggat tgcatgatgg gctggcacac      900

agcatgagct cagtaagtgt cagtcactgt tatcccccag gggcatgcat gccgctgcct      960

ccaggaggcc ctccaactcg cagtggcctc tccctacatg ggttcccact gagctgtgat     1020

cctgtggcct tgagccccat ctggctgccc tggacaatgt tggtcctcag ctccccagcg     1080

ggatcaacag tggggagagc agtgggtgga tctgcccgcc aggcagtacc tgagtgcaca     1140

gtgggcaccc cacagtcaaa ggatgcatag tctggtttcc aaggaggaac cccaggctag     1200

gtggaatgag ggaaatgcaa tctcagggcc agataacatc acagatactt taaacctgca     1260

attaatttct ggttgtttga ccaaatccgg ccaagtttcc cgggtgacac tgcagagctg     1320

tggaacagca tgggcttgga gtcagacctg ttgcacatct ggctctgcca tgtgatgcaa     1380

cctcaggctt gtcacgaggc ctccttgagc ctcagttgct aatatgccaa atggggatga     1440

tattgctcac cttacagctt gtaagagtgg agggagctgc gtgcgccagg tgcctggcat     1500

gcagcgggca ctcaaccaga ttgaattccc ttcccaggga agaattcaag gatatcttcc     1560

cacccactaa ggagacatgt gatgggatct ggggtgagaa ttgctctttt taaagctctc     1620

agaactgtaa ggggctccac ccaccaatgg ctggtgttca ctgagctctt cgtgcccaga     1680

cctgcactgg ggatttatcg agcacatggc tggcttctga cttccgaaga gctcgccatt     1740

ctggtcagtg cctgagggca cagaaatgtt tgaggtctat gggacgcctg gcgtggacat     1800

ctacatctct cccaacatgg agaggggccg ggagcgtgca gacaccaggc ggtggcgctt     1860

tgacgcgact ttggagatca tcgtggtcat gaactccccc agcaatgacc tcaacgacag     1920

ccatgttcag atttcctacc actccagcca tgagcctctg cccctggcct atgcggtgct     1980

ctacctcacc tgtgttgaca tctctctgga ttgcgacctg aactgtgagg gaaggcagga     2040

caggaacttt gtagacaagc ggcagtgggt ctgggggccc agtgggtatg gcggcatctt     2100

gctggtgaac tgtgaccgtg atgatccgag ctgtgatgtc caggacaatt gtgaccagca     2160

cgtgcactgc ctgcaagacc tggaagacat gtctgtcatg gtcctgcgga cgcagggccc     2220

tgcagccctc tttgatgacc acaaacttgt cctccatacc tccagctatg atgccaaacg     2280

ggcacaggtc ttccacatct gcggtcctga ggatgtgtgt gaggcctata ggcatgtgct     2340

gggccaagat aaggtgtcct atgaggtacc ccgcttgcat ggggatgagg agcgcttctt     2400

cgtggaaggc ctgtccttcc ctgatgccgg cttcacagga ctcatctcct tccatgtcac     2460

tctgctggac gactccaacg aggatttctc ggcatcccct atcttcactg acactgtggt     2520

gttccgagtg gtaccctgga tcatgacgcc cagcactctg ccacccctag aggtgtatgt     2580

gtgccgtgtg aggaacaaca cgtgttttgt ggatgcggtg gcagagctgg ccaggaaggc     2640

cggctgcaag ctgaccatct gcccacaggc cgagaaccgc aacgaccgct ggatccagga     2700

tgagatggag ctgggctacg ttcaggcgcc gcacaagacc ctcccggtgg tctttgactc     2760

cccaaggaat ggggaactgc aggatttccc ttacaaaaga atcctgggtc cagattttgg     2820

ttacgtgact cgggaaccac gcgacaggtc tgtgagtggc ctggactcct ttgggaacct     2880

ggaggtcagc cctccagtgg tggccaatgg gaaagagtac cccctgggga ggatcctcat     2940

tgggggcaac ctgcctgggt caagtggccg cagggtcacc caggtggtgc gggacttcct     3000

ccatgcccag aaggtgcagc cccccgtgga gctctttgtg gactggttgg ccgtgggcca     3060

tgtggatgag tttctgagct ttgtccctgc ccccgatggg aagggcttcc ggatgctcct     3120

ggccagccct ggggcctgct tcaagctctt ccaggaaaag cagaagtgtg gccacgggag     3180

ggccctcctg ttccaggggg ttgttgatga tgagcaggtc aagaccatct ccatcaacca     3240

ggtgctctcc aataaagacc tcatcaacta caataagttt gtgcagagct gcatcgactg     3300

gaaccgtgag gtgctgaagc gggagctggg cctggcagag tgtgacatca ttgacatccc     3360

acagctcttc aagaccgaga ggaaaaaagc aacggccttc ttccctgact tggtgaacat     3420

gctggtgctg gggaagcacc tgggcatccc caagcccttt gggcccatca tcaatggctg     3480

ctgctgcctg gaggagaagg tgcggtccct gctggagccg ctgggcctcc actgcacctt     3540

cattgatgac ttcactccat accacatgct gcatggggag gtgcactgtg gcaccaatgt     3600

gtgcagaaag cccttctctt tcaagtggtg gaacatggtg ccctgagaca gctcccaccc     3660

accatcctgt ccccctgggg cgggcattgg cccaggtggt ggagacagag acaggcccct     3720

gaacgataag caccaagaga ccccaaggct ccagatggaa cactgagggt gaccgtccct     3780

ctcagaagcc ttttccctgg aagtgtccat gcctcacctg caacccatgt ggttctcaga     3840

cttgaatctt ctcggccccc caaaaagaag gacctcattt cttatagcct ctcctgtgat     3900

tcaacacaac ccatggagat gtccccttct cactctgaaa tcatccattt ggggacaaat     3960

ccacattggg gtctagaaac atccacgtat ctcatcagcc atcttgtcct gtgcatccta     4020

acagaggaag gatccatgat tctgctttgg tccaattgct tcctctctgc agaggaacaa     4080

ccctaaaacc agaccactcc acgcaggaca ggcaggagag attcttccta aagcctcccc     4140

cataaaaagg gagctgtgga tccacttaga tcagggcgga accatctttc acccggccaa     4200

gctcctgccc agatgttgac cctcacccag cgtgagctgt cacatagtag gagcttctag     4260

atgcatgtgg aagcaatgag agttgtccct tagccttata aactccccat gatctgacat     4320

gcagaaatcc agccttgtcc agaatcctcc tggaatttct tggagacgaa agtatctggg     4380

ggattgttgg gtactaggga gactgggtac aagggtgaaa agtagttccc ataatacaca     4440

tggttgacta tggtgatcca ccttgtgatg gttaatatta ggtgtctgga gaaggttgct     4500

tcattggccc tgggacttct ctctgcagga ggagagaacg ctgcctctcc tctggattgg     4560

tctcaggctc tctgttggcc tttggtcagc gtttccacat cctgctctgc tgcaggagag     4620

ggggctaagg ggctggatcc accaaggcag ctcacagcgg gaaaactctg ggaatgaacc     4680

actgaattca ggggatgggg gtgggggggc ggttctcgag gtgtgtgcca gctacacgtg     4740

tgttctgtat gggtccagct gcgtttccat cactcgctaa taaatcaaca gaaacacaaa     4800


<210>  30
<211>  626
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X1 [Homo sapiens]

<400>  30

Met Phe Glu Val Tyr Gly Thr Pro Gly Val Asp Ile Tyr Ile Ser Pro 
1               5                   10                  15      


Asn Met Glu Arg Gly Arg Glu Arg Ala Asp Thr Arg Arg Trp Arg Phe 
            20                  25                  30          


Asp Ala Thr Leu Glu Ile Ile Val Val Met Asn Ser Pro Ser Asn Asp 
        35                  40                  45              


Leu Asn Asp Ser His Val Gln Ile Ser Tyr His Ser Ser His Glu Pro 
    50                  55                  60                  


Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu Thr Cys Val Asp Ile Ser 
65                  70                  75                  80  


Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg Gln Asp Arg Asn Phe Val 
                85                  90                  95      


Asp Lys Arg Gln Trp Val Trp Gly Pro Ser Gly Tyr Gly Gly Ile Leu 
            100                 105                 110         


Leu Val Asn Cys Asp Arg Asp Asp Pro Ser Cys Asp Val Gln Asp Asn 
        115                 120                 125             


Cys Asp Gln His Val His Cys Leu Gln Asp Leu Glu Asp Met Ser Val 
    130                 135                 140                 


Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp Asp His Lys 
145                 150                 155                 160 


Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala Gln Val Phe 
                165                 170                 175     


His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg His Val Leu 
            180                 185                 190         


Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His Gly Asp Glu 
        195                 200                 205             


Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala Gly Phe Thr 
    210                 215                 220                 


Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser Asn Glu Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe Arg Val Val 
                245                 250                 255     


Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu Val Tyr Val 
            260                 265                 270         


Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val Ala Glu Leu 
        275                 280                 285             


Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln Ala Glu Asn 
    290                 295                 300                 


Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly Tyr Val Gln 
305                 310                 315                 320 


Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro Arg Asn Gly 
                325                 330                 335     


Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro Asp Phe Gly 
            340                 345                 350         


Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly Leu Asp Ser 
        355                 360                 365             


Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro Gly Ser Ser 
385                 390                 395                 400 


Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His Ala Gln Lys 
                405                 410                 415     


Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala Val Gly His 
            420                 425                 430         


Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly Lys Gly Phe 
        435                 440                 445             


Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu Phe Gln Glu 
    450                 455                 460                 


Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln Gly Val Val 
465                 470                 475                 480 


Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val Leu Ser Asn 
                485                 490                 495     


Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys Ile Asp Trp 
            500                 505                 510         


Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu Cys Asp Ile 
        515                 520                 525             


Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys Ala Thr Ala 
    530                 535                 540                 


Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys His Leu Gly 
545                 550                 555                 560 


Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys Cys Leu Glu 
                565                 570                 575     


Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His Cys Thr Phe 
            580                 585                 590         


Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu Val His Cys 
        595                 600                 605             


Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp Trp Asn Met 
    610                 615                 620                 


Val Pro 
625     


<210>  31
<211>  4800
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X1, mRNA

<400>  31
tctccctggt tctgccattt cccctgtggg gggctgccca gggccaaaca ggccagaggg       60

ctccaccagc cctggaaatt acaggctttg ggagtagggt tgccagataa aataaaagat      120

gcctagttaa aattgaattt caggtaaata attaataatt tttttagtat aagtgtatcc      180

caaatacttc acgggagtac caaacaatga ttgactgttc acttgaaatt caagtccaac      240

tgagctttct gtatttttat ttgctaagtc tggcagccct gcttaggagg agaaacaggt      300

gtgtctgtcc ctcccaactg gtgaggacac ctgacagggg cccagacacc agagtgggac      360

ctgcctgatg gagagaagct tgggcttggt ttatttccct tttcataaaa aagctgcttt      420

gagatgtaag agaatcatgt tggtggaaga gtgaagaggt tgttttgggg gaggtctgcc      480

ttactctgag ggaagatggg aagcgggggg agtggccagc tgtggaaatt tggggtagtc      540

ccctacgtat cctgtgcctc agtttcccca tgtgtaaaca ggagtaatta tctcatcctg      600

gggctgcagt gaggatcaga tgagctaatg tacaaaaagg cttaggcagg cctgccgtga      660

taagagtgca gaggctgggg gctttttatg ttatggtatt gttgttatta ttactcctgg      720

ggaggtggtg ggcaagagtg tggactgagg agccacatgg ctgggtttgg atcccagccc      780

ggccacagac cttgggcaag ttacttaacc tcggctttct catctgtata atgggagaca      840

ataatagata gtgcctccct tctagggtta ttgagaggat tgcatgatgg gctggcacac      900

agcatgagct cagtaagtgt cagtcactgt tatcccccag gggcatgcat gccgctgcct      960

ccaggaggcc ctccaactcg cagtggcctc tccctacatg ggttcccact gagctgtgat     1020

cctgtggcct tgagccccat ctggctgccc tggacaatgt tggtcctcag ctccccagcg     1080

ggatcaacag tggggagagc agtgggtgga tctgcccgcc aggcagtacc tgagtgcaca     1140

gtgggcaccc cacagtcaaa ggatgcatag tctggtttcc aaggaggaac cccaggctag     1200

gtggaatgag ggaaatgcaa tctcagggcc agataacatc acagatactt taaacctgca     1260

attaatttct ggttgtttga ccaaatccgg ccaagtttcc cgggtgacac tgcagagctg     1320

tggaacagca tgggcttgga gtcagacctg ttgcacatct ggctctgcca tgtgatgcaa     1380

cctcaggctt gtcacgaggc ctccttgagc ctcagttgct aatatgccaa atggggatga     1440

tattgctcac cttacagctt gtaagagtgg agggagctgc gtgcgccagg tgcctggcat     1500

gcagcgggca ctcaaccaga ttgaattccc ttcccaggga agaattcaag gatatcttcc     1560

cacccactaa ggagacatgt gatgggatct ggggtgagaa ttgctctttt taaagctctc     1620

agaactgtaa ggggctccac ccaccaatgg ctggtgttca ctgagctctt cgtgcccaga     1680

cctgcactgg ggatttatcg agcacatggc tggcttctga cttccgaaga gctcgccatt     1740

ctggtcagtg cctgagggca cagaaatgtt tgaggtctat gggacgcctg gcgtggacat     1800

ctacatctct cccaacatgg agaggggccg ggagcgtgca gacaccaggc ggtggcgctt     1860

tgacgcgact ttggagatca tcgtggtcat gaactccccc agcaatgacc tcaacgacag     1920

ccatgttcag atttcctacc actccagcca tgagcctctg cccctggcct atgcggtgct     1980

ctacctcacc tgtgttgaca tctctctgga ttgcgacctg aactgtgagg gaaggcagga     2040

caggaacttt gtagacaagc ggcagtgggt ctgggggccc agtgggtatg gcggcatctt     2100

gctggtgaac tgtgaccgtg atgatccgag ctgtgatgtc caggacaatt gtgaccagca     2160

cgtgcactgc ctgcaagacc tggaagacat gtctgtcatg gtcctgcgga cgcagggccc     2220

tgcagccctc tttgatgacc acaaacttgt cctccatacc tccagctatg atgccaaacg     2280

ggcacaggtc ttccacatct gcggtcctga ggatgtgtgt gaggcctata ggcatgtgct     2340

gggccaagat aaggtgtcct atgaggtacc ccgcttgcat ggggatgagg agcgcttctt     2400

cgtggaaggc ctgtccttcc ctgatgccgg cttcacagga ctcatctcct tccatgtcac     2460

tctgctggac gactccaacg aggatttctc ggcatcccct atcttcactg acactgtggt     2520

gttccgagtg gcaccctgga tcatgacgcc cagcactctg ccacccctag aggtgtatgt     2580

gtgccgtgtg aggaacaaca cgtgttttgt ggatgcggtg gcagagctgg ccaggaaggc     2640

cggctgcaag ctgaccatct gcccacaggc cgagaaccgc aacgaccgct ggatccagga     2700

tgagatggag ctgggctacg ttcaggcgcc gcacaagacc ctcccggtgg tctttgactc     2760

cccaaggaat ggggaactgc aggatttccc ttacaaaaga atcctgggtc cagattttgg     2820

ttacgtgact cgggaaccac gcgacaggtc tgtgagtggc ctggactcct ttgggaacct     2880

ggaggtcagc cctccagtgg tggccaatgg gaaagagtac cccctgggga ggatcctcat     2940

tgggggcaac ctgcctgggt caagtggccg cagggtcacc caggtggtgc gggacttcct     3000

ccatgcccag aaggtgcagc cccccgtgga gctctttgtg gactggttgg ccgtgggcca     3060

tgtggatgag tttctgagct ttgtccctgc ccccgatggg aagggcttcc ggatgctcct     3120

ggccagccct ggggcctgct tcaagctctt ccaggaaaag cagaagtgtg gccacgggag     3180

ggccctcctg ttccaggggg ttgttgatga tgagcaggtc aagaccatct ccatcaacca     3240

ggtgctctcc aataaagacc tcatcaacta caataagttt gtgcagagct gcatcgactg     3300

gaaccgtgag gtgctgaagc gggagctggg cctggcagag tgtgacatca ttgacatccc     3360

acagctcttc aagaccgaga ggaaaaaagc aacgaccttc ttccctgact tggtgaacat     3420

gctggtgctg gggaagcacc tgggcatccc caagcccttt gggcccatca tcaatggctg     3480

ctgctgcctg gaggagaagg tgcggtccct gctggagccg ctgggcctcc actgcacctt     3540

cattgatgac ttcactccat accacatgct gcatggggag gtgcactgtg gcaccaatgt     3600

gtgcagaaag cccttctctt tcaagtggtg gaacatggtg ccctgagaca gctcccaccc     3660

accatcctgt ccccctgggg cgggcattgg cccaggtggt ggagacagag acaggcccct     3720

gaacgataag caccaagaga ccccaaggct ccagatggaa cactgagggt gaccgtccct     3780

ctcagaagcc ttttccctgg aagtgtccat gcctcacctg caacccatgt ggttctcaga     3840

cttgaatctt ctcggccccc caaaaagaag gacctcattt cttatagcct ctcctgtgat     3900

tcaacacaac ccatggagat gtccccttct cactctgaaa tcatccattt ggggacaaat     3960

ccacattggg gtctagaaac atccacgtat ctcatcagcc atcttgtcct gtgcatccta     4020

acagaggaag gatccatgat tctgctttgg tccaattgct tcctctctgc agaggaacaa     4080

ccctaaaacc agaccactcc acgcaggaca ggcaggagag attcttccta aagcctcccc     4140

cataaaaagg gagctgtgga tccacttaga tcagggcgga accatctttc acccggccaa     4200

gctcctgccc agatgttgac cctcacccag cgtgagctgt cacatagtag gagcttctag     4260

atgcatgtgg aagcaatgag agttgtccct tagccttata aactccccat gatctgacat     4320

gcagaaatcc agccttgtcc agaatcctcc tggaatttct tggagacgaa agtatctggg     4380

ggattgttgg gtactaggga gactgggtac aagggtgaaa agtagttccc ataatacaca     4440

tggttgacta tggtgatcca ccttgtgatg gttaatatta ggtgtctgga gaaggttgct     4500

tcattggccc tgggacttct ctctgcagga ggagagaacg ctgcctctcc tctggattgg     4560

tctcaggctc tctgttggcc tttggtcagc gtttccacat cctgctctgc tgcaggagag     4620

ggggctaagg ggctggatcc accaaggcag ctcacagcgg gaaaactctg ggaatgaacc     4680

actgaattca ggggatgggg gtgggggggc ggttctcgag gtgtgtgcca gctacacgtg     4740

tgttctgtat gggtccagct gcgtttccat cactcgctaa taaatcaaca gaaacacaaa     4800


<210>  32
<211>  626
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X1 [Homo sapiens]

<400>  32

Met Phe Glu Val Tyr Gly Thr Pro Gly Val Asp Ile Tyr Ile Ser Pro 
1               5                   10                  15      


Asn Met Glu Arg Gly Arg Glu Arg Ala Asp Thr Arg Arg Trp Arg Phe 
            20                  25                  30          


Asp Ala Thr Leu Glu Ile Ile Val Val Met Asn Ser Pro Ser Asn Asp 
        35                  40                  45              


Leu Asn Asp Ser His Val Gln Ile Ser Tyr His Ser Ser His Glu Pro 
    50                  55                  60                  


Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu Thr Cys Val Asp Ile Ser 
65                  70                  75                  80  


Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg Gln Asp Arg Asn Phe Val 
                85                  90                  95      


Asp Lys Arg Gln Trp Val Trp Gly Pro Ser Gly Tyr Gly Gly Ile Leu 
            100                 105                 110         


Leu Val Asn Cys Asp Arg Asp Asp Pro Ser Cys Asp Val Gln Asp Asn 
        115                 120                 125             


Cys Asp Gln His Val His Cys Leu Gln Asp Leu Glu Asp Met Ser Val 
    130                 135                 140                 


Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp Asp His Lys 
145                 150                 155                 160 


Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala Gln Val Phe 
                165                 170                 175     


His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg His Val Leu 
            180                 185                 190         


Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His Gly Asp Glu 
        195                 200                 205             


Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala Gly Phe Thr 
    210                 215                 220                 


Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser Asn Glu Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe Arg Val Ala 
                245                 250                 255     


Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu Val Tyr Val 
            260                 265                 270         


Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val Ala Glu Leu 
        275                 280                 285             


Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln Ala Glu Asn 
    290                 295                 300                 


Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly Tyr Val Gln 
305                 310                 315                 320 


Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro Arg Asn Gly 
                325                 330                 335     


Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro Asp Phe Gly 
            340                 345                 350         


Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly Leu Asp Ser 
        355                 360                 365             


Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro Gly Ser Ser 
385                 390                 395                 400 


Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His Ala Gln Lys 
                405                 410                 415     


Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala Val Gly His 
            420                 425                 430         


Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly Lys Gly Phe 
        435                 440                 445             


Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu Phe Gln Glu 
    450                 455                 460                 


Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln Gly Val Val 
465                 470                 475                 480 


Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val Leu Ser Asn 
                485                 490                 495     


Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys Ile Asp Trp 
            500                 505                 510         


Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu Cys Asp Ile 
        515                 520                 525             


Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys Ala Thr Thr 
    530                 535                 540                 


Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys His Leu Gly 
545                 550                 555                 560 


Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys Cys Leu Glu 
                565                 570                 575     


Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His Cys Thr Phe 
            580                 585                 590         


Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu Val His Cys 
        595                 600                 605             


Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp Trp Asn Met 
    610                 615                 620                 


Val Pro 
625     


<210>  33
<211>  4800
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X1, mRNA

<400>  33
tctccctggt tctgccattt cccctgtggg gggctgccca gggccaaaca ggccagaggg       60

ctccaccagc cctggaaatt acaggctttg ggagtagggt tgccagataa aataaaagat      120

gcctagttaa aattgaattt caggtaaata attaataatt tttttagtat aagtgtatcc      180

caaatacttc acgggagtac caaacaatga ttgactgttc acttgaaatt caagtccaac      240

tgagctttct gtatttttat ttgctaagtc tggcagccct gcttaggagg agaaacaggt      300

gtgtctgtcc ctcccaactg gtgaggacac ctgacagggg cccagacacc agagtgggac      360

ctgcctgatg gagagaagct tgggcttggt ttatttccct tttcataaaa aagctgcttt      420

gagatgtaag agaatcatgt tggtggaaga gtgaagaggt tgttttgggg gaggtctgcc      480

ttactctgag ggaagatggg aagcgggggg agtggccagc tgtggaaatt tggggtagtc      540

ccctacgtat cctgtgcctc agtttcccca tgtgtaaaca ggagtaatta tctcatcctg      600

gggctgcagt gaggatcaga tgagctaatg tacaaaaagg cttaggcagg cctgccgtga      660

taagagtgca gaggctgggg gctttttatg ttatggtatt gttgttatta ttactcctgg      720

ggaggtggtg ggcaagagtg tggactgagg agccacatgg ctgggtttgg atcccagccc      780

ggccacagac cttgggcaag ttacttaacc tcggctttct catctgtata atgggagaca      840

ataatagata gtgcctccct tctagggtta ttgagaggat tgcatgatgg gctggcacac      900

agcatgagct cagtaagtgt cagtcactgt tatcccccag gggcatgcat gccgctgcct      960

ccaggaggcc ctccaactcg cagtggcctc tccctacatg ggttcccact gagctgtgat     1020

cctgtggcct tgagccccat ctggctgccc tggacaatgt tggtcctcag ctccccagcg     1080

ggatcaacag tggggagagc agtgggtgga tctgcccgcc aggcagtacc tgagtgcaca     1140

gtgggcaccc cacagtcaaa ggatgcatag tctggtttcc aaggaggaac cccaggctag     1200

gtggaatgag ggaaatgcaa tctcagggcc agataacatc acagatactt taaacctgca     1260

attaatttct ggttgtttga ccaaatccgg ccaagtttcc cgggtgacac tgcagagctg     1320

tggaacagca tgggcttgga gtcagacctg ttgcacatct ggctctgcca tgtgatgcaa     1380

cctcaggctt gtcacgaggc ctccttgagc ctcagttgct aatatgccaa atggggatga     1440

tattgctcac cttacagctt gtaagagtgg agggagctgc gtgcgccagg tgcctggcat     1500

gcagcgggca ctcaaccaga ttgaattccc ttcccaggga agaattcaag gatatcttcc     1560

cacccactaa ggagacatgt gatgggatct ggggtgagaa ttgctctttt taaagctctc     1620

agaactgtaa ggggctccac ccaccaatgg ctggtgttca ctgagctctt cgtgcccaga     1680

cctgcactgg ggatttatcg agcacatggc tggcttctga cttccgaaga gctcgccatt     1740

ctggtcagtg cctgagggca cagaaatgtt tgaggtctat gggacgcctg gcgtggacat     1800

ctacatctct cccaacatgg agaggggccg ggagcgtgca gacaccaggc ggtggcgctt     1860

tgacgcgact ttggagatca tcgtggtcat gaactccccc agcaatgacc tcaacgacag     1920

ccatgttcag atttcctacc actccagcca tgagcctctg cccctggcct atgcggtgct     1980

ctacctcacc tgtgttgaca tctctctgga ttgcgacctg aactgtgagg gaaggcagga     2040

caggaacttt gtagacaagc ggcagtgggt ctgggggccc agtgggtatg gcggcatctt     2100

gctggtgaac tgtgaccgtg atgatccgag ctgtgatgtc caggacaatt gtgaccagca     2160

cgtgcactgc ctgcaagacc tggaagacat gtctgtcatg gtcctgcgga cgcagggccc     2220

tgcagccctc tttgatgacc acaaacttgt cctccatacc tccagctatg atgccaaacg     2280

ggcacaggtc ttccacatct gcggtcctga ggatgtgtgt gaggcctata ggcatgtgct     2340

gggccaagat aaggtgtcct atgaggtacc ccgcttgcat ggggatgagg agcgcttctt     2400

cgtggaaggc ctgtccttcc ctgatgccgg cttcacagga ctcatctcct tccatgtcac     2460

tctgctggac gactccaacg aggatttctc ggcatcccct atcttcactg acactgtggt     2520

gttccgagtg gcaccctgga tcatgacgcc cagcactctg ccacccctag aggtgtatgt     2580

gtgccgtgtg aggaacaaca cgtgttttgt ggatgcggtg gcagagctgg ccaggaaggc     2640

cggctgcaag ctgaccatct gcccacaggc cgagaaccgc aacgaccgct ggatccagga     2700

tgagatggag ctgggctacg ttcaggcgcc gcacaagacc ctcccggtgg tctttgactc     2760

cccaaggaat ggggaactgc aggatttccc ttacaaaaga atcctgggtc cagattttgg     2820

ttacgtgact cgggaaccac gcgacaggtc tgtgagtggc ctggactcct ttgggaacct     2880

ggaggtcagc cctccagtgg tggccaatgg gaaagagtac cccctgggga ggatcctcat     2940

tgggggcaac ctgcctgggt caagtggccg cagggtcacc caggtggtgc gggacttcct     3000

ccatgcccag aaggtgcagc cccccgtgga gctctttgtg gactggttgg ccgtgggcca     3060

tgtggatgag tttctgagct ttgtccctgc ccccgatggg aagggcttcc ggatgctcct     3120

ggccagccct ggggcctgct tcaagctctt ccaggaaaag cagaagtgtg gccacgggag     3180

ggccctcctg ttccaggggg ttgttgatga tgagcaggtc aagaccatct ccatcaacca     3240

ggtgctctcc aataaagacc tcatcaacta caataagttt gtgcagagct gcatcgactg     3300

gaaccgtgag gtgctgaagc gggagctggg cctggcagag tgtgacatca ttgacatccc     3360

acagctcttc aagaccgaga ggaaaaaagc aacggccttc ttccctgact tggtgaacat     3420

gctggtgctg gggaagcacc tgggcatccc caagcccttt gggaccatca tcaatggctg     3480

ctgctgcctg gaggagaagg tgcggtccct gctggagccg ctgggcctcc actgcacctt     3540

cattgatgac ttcactccat accacatgct gcatggggag gtgcactgtg gcaccaatgt     3600

gtgcagaaag cccttctctt tcaagtggtg gaacatggtg ccctgagaca gctcccaccc     3660

accatcctgt ccccctgggg cgggcattgg cccaggtggt ggagacagag acaggcccct     3720

gaacgataag caccaagaga ccccaaggct ccagatggaa cactgagggt gaccgtccct     3780

ctcagaagcc ttttccctgg aagtgtccat gcctcacctg caacccatgt ggttctcaga     3840

cttgaatctt ctcggccccc caaaaagaag gacctcattt cttatagcct ctcctgtgat     3900

tcaacacaac ccatggagat gtccccttct cactctgaaa tcatccattt ggggacaaat     3960

ccacattggg gtctagaaac atccacgtat ctcatcagcc atcttgtcct gtgcatccta     4020

acagaggaag gatccatgat tctgctttgg tccaattgct tcctctctgc agaggaacaa     4080

ccctaaaacc agaccactcc acgcaggaca ggcaggagag attcttccta aagcctcccc     4140

cataaaaagg gagctgtgga tccacttaga tcagggcgga accatctttc acccggccaa     4200

gctcctgccc agatgttgac cctcacccag cgtgagctgt cacatagtag gagcttctag     4260

atgcatgtgg aagcaatgag agttgtccct tagccttata aactccccat gatctgacat     4320

gcagaaatcc agccttgtcc agaatcctcc tggaatttct tggagacgaa agtatctggg     4380

ggattgttgg gtactaggga gactgggtac aagggtgaaa agtagttccc ataatacaca     4440

tggttgacta tggtgatcca ccttgtgatg gttaatatta ggtgtctgga gaaggttgct     4500

tcattggccc tgggacttct ctctgcagga ggagagaacg ctgcctctcc tctggattgg     4560

tctcaggctc tctgttggcc tttggtcagc gtttccacat cctgctctgc tgcaggagag     4620

ggggctaagg ggctggatcc accaaggcag ctcacagcgg gaaaactctg ggaatgaacc     4680

actgaattca ggggatgggg gtgggggggc ggttctcgag gtgtgtgcca gctacacgtg     4740

tgttctgtat gggtccagct gcgtttccat cactcgctaa taaatcaaca gaaacacaaa     4800


<210>  34
<211>  626
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X1 [Homo sapiens]

<400>  34

Met Phe Glu Val Tyr Gly Thr Pro Gly Val Asp Ile Tyr Ile Ser Pro 
1               5                   10                  15      


Asn Met Glu Arg Gly Arg Glu Arg Ala Asp Thr Arg Arg Trp Arg Phe 
            20                  25                  30          


Asp Ala Thr Leu Glu Ile Ile Val Val Met Asn Ser Pro Ser Asn Asp 
        35                  40                  45              


Leu Asn Asp Ser His Val Gln Ile Ser Tyr His Ser Ser His Glu Pro 
    50                  55                  60                  


Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu Thr Cys Val Asp Ile Ser 
65                  70                  75                  80  


Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg Gln Asp Arg Asn Phe Val 
                85                  90                  95      


Asp Lys Arg Gln Trp Val Trp Gly Pro Ser Gly Tyr Gly Gly Ile Leu 
            100                 105                 110         


Leu Val Asn Cys Asp Arg Asp Asp Pro Ser Cys Asp Val Gln Asp Asn 
        115                 120                 125             


Cys Asp Gln His Val His Cys Leu Gln Asp Leu Glu Asp Met Ser Val 
    130                 135                 140                 


Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp Asp His Lys 
145                 150                 155                 160 


Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala Gln Val Phe 
                165                 170                 175     


His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg His Val Leu 
            180                 185                 190         


Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His Gly Asp Glu 
        195                 200                 205             


Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala Gly Phe Thr 
    210                 215                 220                 


Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser Asn Glu Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe Arg Val Ala 
                245                 250                 255     


Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu Val Tyr Val 
            260                 265                 270         


Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val Ala Glu Leu 
        275                 280                 285             


Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln Ala Glu Asn 
    290                 295                 300                 


Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly Tyr Val Gln 
305                 310                 315                 320 


Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro Arg Asn Gly 
                325                 330                 335     


Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro Asp Phe Gly 
            340                 345                 350         


Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly Leu Asp Ser 
        355                 360                 365             


Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro Gly Ser Ser 
385                 390                 395                 400 


Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His Ala Gln Lys 
                405                 410                 415     


Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala Val Gly His 
            420                 425                 430         


Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly Lys Gly Phe 
        435                 440                 445             


Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu Phe Gln Glu 
    450                 455                 460                 


Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln Gly Val Val 
465                 470                 475                 480 


Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val Leu Ser Asn 
                485                 490                 495     


Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys Ile Asp Trp 
            500                 505                 510         


Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu Cys Asp Ile 
        515                 520                 525             


Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys Ala Thr Ala 
    530                 535                 540                 


Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys His Leu Gly 
545                 550                 555                 560 


Ile Pro Lys Pro Phe Gly Thr Ile Ile Asn Gly Cys Cys Cys Leu Glu 
                565                 570                 575     


Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His Cys Thr Phe 
            580                 585                 590         


Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu Val His Cys 
        595                 600                 605             


Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp Trp Asn Met 
    610                 615                 620                 


Val Pro 
625     


<210>  35
<211>  4800
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X1, mRNA

<400>  35
tctccctggt tctgccattt cccctgtggg gggctgccca gggccaaaca ggccagaggg       60

ctccaccagc cctggaaatt acaggctttg ggagtagggt tgccagataa aataaaagat      120

gcctagttaa aattgaattt caggtaaata attaataatt tttttagtat aagtgtatcc      180

caaatacttc acgggagtac caaacaatga ttgactgttc acttgaaatt caagtccaac      240

tgagctttct gtatttttat ttgctaagtc tggcagccct gcttaggagg agaaacaggt      300

gtgtctgtcc ctcccaactg gtgaggacac ctgacagggg cccagacacc agagtgggac      360

ctgcctgatg gagagaagct tgggcttggt ttatttccct tttcataaaa aagctgcttt      420

gagatgtaag agaatcatgt tggtggaaga gtgaagaggt tgttttgggg gaggtctgcc      480

ttactctgag ggaagatggg aagcgggggg agtggccagc tgtggaaatt tggggtagtc      540

ccctacgtat cctgtgcctc agtttcccca tgtgtaaaca ggagtaatta tctcatcctg      600

gggctgcagt gaggatcaga tgagctaatg tacaaaaagg cttaggcagg cctgccgtga      660

taagagtgca gaggctgggg gctttttatg ttatggtatt gttgttatta ttactcctgg      720

ggaggtggtg ggcaagagtg tggactgagg agccacatgg ctgggtttgg atcccagccc      780

ggccacagac cttgggcaag ttacttaacc tcggctttct catctgtata atgggagaca      840

ataatagata gtgcctccct tctagggtta ttgagaggat tgcatgatgg gctggcacac      900

agcatgagct cagtaagtgt cagtcactgt tatcccccag gggcatgcat gccgctgcct      960

ccaggaggcc ctccaactcg cagtggcctc tccctacatg ggttcccact gagctgtgat     1020

cctgtggcct tgagccccat ctggctgccc tggacaatgt tggtcctcag ctccccagcg     1080

ggatcaacag tggggagagc agtgggtgga tctgcccgcc aggcagtacc tgagtgcaca     1140

gtgggcaccc cacagtcaaa ggatgcatag tctggtttcc aaggaggaac cccaggctag     1200

gtggaatgag ggaaatgcaa tctcagggcc agataacatc acagatactt taaacctgca     1260

attaatttct ggttgtttga ccaaatccgg ccaagtttcc cgggtgacac tgcagagctg     1320

tggaacagca tgggcttgga gtcagacctg ttgcacatct ggctctgcca tgtgatgcaa     1380

cctcaggctt gtcacgaggc ctccttgagc ctcagttgct aatatgccaa atggggatga     1440

tattgctcac cttacagctt gtaagagtgg agggagctgc gtgcgccagg tgcctggcat     1500

gcagcgggca ctcaaccaga ttgaattccc ttcccaggga agaattcaag gatatcttcc     1560

cacccactaa ggagacatgt gatgggatct ggggtgagaa ttgctctttt taaagctctc     1620

agaactgtaa ggggctccac ccaccaatgg ctggtgttca ctgagctctt cgtgcccaga     1680

cctgcactgg ggatttatcg agcacatggc tggcttctga cttccgaaga gctcgccatt     1740

ctggtcagtg cctgagggca cagaaatgtt tgaggtctat gggacgcctg gcgtggacat     1800

ctacatctct cccaacatgg agaggggccg ggagcgtgca gacaccaggc ggtggcgctt     1860

tgacgcgact ttggagatca tcgtggtcat gaactccccc agcaatgacc tcaacgacag     1920

ccatgttcag atttcctacc actccagcca tgagcctctg cccctggcct atgcggtgct     1980

ctacctcacc tgtgttgaca tctctctgga ttgcgacctg aactgtgagg gaaggcagga     2040

caggaacttt gtagacaagc ggcagtgggt ctgggggccc agtgggtatg gcggcatctt     2100

gctggtgaac tgtgaccgtg atgatccgag ctgtgatgtc caggacaatt gtgaccagca     2160

cgtgcactgc ctgcaagacc tggaagacat gtctgtcatg gtcctgcgga cgcagggccc     2220

tgcagccctc tttgatgacc acaaacttgt cctccatacc tccagctatg atgccaaacg     2280

ggcacaggtc ttccacatct gcggtcctga ggatgtgtgt gaggcctata ggcatgtgct     2340

gggccaagat aaggtgtcct atgaggtacc ccgcttgcat ggggatgagg agcgcttctt     2400

cgtggaaggc ctgtccttcc ctgatgccgg cttcacagga ctcatctcct tccatgtcac     2460

tctgctggac gactccaacg aggatttctc ggcatcccct atcttcactg acactgtggt     2520

gttccgagtg gcaccctgga tcatgacgcc cagcactctg ccacccctag aggtgtatgt     2580

gtgccgtgtg aggaacaaca cgtgttttgt ggatgcggtg gcagagctgg ccaggaaggc     2640

cggctgcaag ctgaccatct gcccacaggc cgagaaccgc aacgaccgct ggatccagga     2700

tgagatggag ctgggctacg ttcaggcgcc gcacaagacc ctcccggtgg tctttgactc     2760

cccaaggaat ggggaactgc aggatttccc ttacaaaaga atcctgggtc cagattttgg     2820

ttacgtgact cgggaaccac gcgacaggtc tgtgagtggc ctggactcct ttgggaacct     2880

ggaggtcagc cctccagtgg tggccaatgg gaaagagtac cccctgggga ggatcctcat     2940

tgggggcaac ctgcctgggt caagtggccg cagggtcacc caggtggtgc gggacttcct     3000

ccatgcccag aaggtgcagc cccccgtgga gctctttgtg gactggttgg ccgtgggcca     3060

tgtggatgag tttctgagct ttgtccctgc ccccgatggg aagggcttcc ggatgctcct     3120

ggccagccct ggggcctgct tcaagctctt ccaggaaaag cagaagtgtg gccacgggag     3180

ggccctcctg ttccaggggg ttgttgatga tgagcaggtc aagaccatct ccatcaacca     3240

ggtgctctcc aataaagacc tcatcaacta caataagttt gtgcagagct gcatcgactg     3300

gaaccgtgag gtgctgaagc gggagctggg cctggcagag tgtgacatca ttgacatccc     3360

acagctcttc aagaccgaga ggaaaaaagc aacggccttc ttccctgact tggtgaacat     3420

gctggtgctg gggaagcacc tgggcatccc caagcccttt gggcccatca tcaatggctg     3480

ctgctgcctg gaggagaagg tgcagtccct gctggagccg ctgggcctcc actgcacctt     3540

cattgatgac ttcactccat accacatgct gcatggggag gtgcactgtg gcaccaatgt     3600

gtgcagaaag cccttctctt tcaagtggtg gaacatggtg ccctgagaca gctcccaccc     3660

accatcctgt ccccctgggg cgggcattgg cccaggtggt ggagacagag acaggcccct     3720

gaacgataag caccaagaga ccccaaggct ccagatggaa cactgagggt gaccgtccct     3780

ctcagaagcc ttttccctgg aagtgtccat gcctcacctg caacccatgt ggttctcaga     3840

cttgaatctt ctcggccccc caaaaagaag gacctcattt cttatagcct ctcctgtgat     3900

tcaacacaac ccatggagat gtccccttct cactctgaaa tcatccattt ggggacaaat     3960

ccacattggg gtctagaaac atccacgtat ctcatcagcc atcttgtcct gtgcatccta     4020

acagaggaag gatccatgat tctgctttgg tccaattgct tcctctctgc agaggaacaa     4080

ccctaaaacc agaccactcc acgcaggaca ggcaggagag attcttccta aagcctcccc     4140

cataaaaagg gagctgtgga tccacttaga tcagggcgga accatctttc acccggccaa     4200

gctcctgccc agatgttgac cctcacccag cgtgagctgt cacatagtag gagcttctag     4260

atgcatgtgg aagcaatgag agttgtccct tagccttata aactccccat gatctgacat     4320

gcagaaatcc agccttgtcc agaatcctcc tggaatttct tggagacgaa agtatctggg     4380

ggattgttgg gtactaggga gactgggtac aagggtgaaa agtagttccc ataatacaca     4440

tggttgacta tggtgatcca ccttgtgatg gttaatatta ggtgtctgga gaaggttgct     4500

tcattggccc tgggacttct ctctgcagga ggagagaacg ctgcctctcc tctggattgg     4560

tctcaggctc tctgttggcc tttggtcagc gtttccacat cctgctctgc tgcaggagag     4620

ggggctaagg ggctggatcc accaaggcag ctcacagcgg gaaaactctg ggaatgaacc     4680

actgaattca ggggatgggg gtgggggggc ggttctcgag gtgtgtgcca gctacacgtg     4740

tgttctgtat gggtccagct gcgtttccat cactcgctaa taaatcaaca gaaacacaaa     4800


<210>  36
<211>  626
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X1 [Homo sapiens]

<400>  36

Met Phe Glu Val Tyr Gly Thr Pro Gly Val Asp Ile Tyr Ile Ser Pro 
1               5                   10                  15      


Asn Met Glu Arg Gly Arg Glu Arg Ala Asp Thr Arg Arg Trp Arg Phe 
            20                  25                  30          


Asp Ala Thr Leu Glu Ile Ile Val Val Met Asn Ser Pro Ser Asn Asp 
        35                  40                  45              


Leu Asn Asp Ser His Val Gln Ile Ser Tyr His Ser Ser His Glu Pro 
    50                  55                  60                  


Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu Thr Cys Val Asp Ile Ser 
65                  70                  75                  80  


Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg Gln Asp Arg Asn Phe Val 
                85                  90                  95      


Asp Lys Arg Gln Trp Val Trp Gly Pro Ser Gly Tyr Gly Gly Ile Leu 
            100                 105                 110         


Leu Val Asn Cys Asp Arg Asp Asp Pro Ser Cys Asp Val Gln Asp Asn 
        115                 120                 125             


Cys Asp Gln His Val His Cys Leu Gln Asp Leu Glu Asp Met Ser Val 
    130                 135                 140                 


Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp Asp His Lys 
145                 150                 155                 160 


Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala Gln Val Phe 
                165                 170                 175     


His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg His Val Leu 
            180                 185                 190         


Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His Gly Asp Glu 
        195                 200                 205             


Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala Gly Phe Thr 
    210                 215                 220                 


Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser Asn Glu Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe Arg Val Ala 
                245                 250                 255     


Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu Val Tyr Val 
            260                 265                 270         


Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val Ala Glu Leu 
        275                 280                 285             


Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln Ala Glu Asn 
    290                 295                 300                 


Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly Tyr Val Gln 
305                 310                 315                 320 


Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro Arg Asn Gly 
                325                 330                 335     


Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro Asp Phe Gly 
            340                 345                 350         


Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly Leu Asp Ser 
        355                 360                 365             


Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro Gly Ser Ser 
385                 390                 395                 400 


Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His Ala Gln Lys 
                405                 410                 415     


Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala Val Gly His 
            420                 425                 430         


Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly Lys Gly Phe 
        435                 440                 445             


Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu Phe Gln Glu 
    450                 455                 460                 


Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln Gly Val Val 
465                 470                 475                 480 


Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val Leu Ser Asn 
                485                 490                 495     


Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys Ile Asp Trp 
            500                 505                 510         


Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu Cys Asp Ile 
        515                 520                 525             


Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys Ala Thr Ala 
    530                 535                 540                 


Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys His Leu Gly 
545                 550                 555                 560 


Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys Cys Leu Glu 
                565                 570                 575     


Glu Lys Val Gln Ser Leu Leu Glu Pro Leu Gly Leu His Cys Thr Phe 
            580                 585                 590         


Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu Val His Cys 
        595                 600                 605             


Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp Trp Asn Met 
    610                 615                 620                 


Val Pro 
625     


<210>  37
<211>  2938
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X2, mRNA

<400>  37
agaaatggat ggatgtgact gtgtgctaat aaaactttat ttatacaaac aggcagtagg       60

ccagatttgg cccacagttc ataatgtgct gatcctgacc taggcgagaa gagaaaccaa      120

atatgaaact gttgaagaac ttgggactga attatgttgg aacttggtgc cctgggagtt      180

aagaggagaa ggtcgagcgg cagtgggtct gggggcccag tgggtatggc ggcatcttgc      240

tggtgaactg tgaccgtgat gatccgagct gtgatgtcca ggacaattgt gaccagcacg      300

tgcactgcct gcaagacctg gaagacatgt ctgtcatggt cctgcggacg cagggccctg      360

cagccctctt tgatgaccac aaacttgtcc tccatacctc cagctatgat gccaaacggg      420

cacaggtctt ccacatctgc ggtcctgagg atgtgtgtga ggcctatagg catgtgctgg      480

gccaagataa ggtgtcctat gaggtacccc gcttgcatgg ggatgaggag cgcttcttcg      540

tggaaggcct gtccttccct gatgccggct tcacaggact catctccttc catgtcactc      600

tgctggacga ctccaacgag gatttctcgg catcccctat cttcactgac actgtggtgt      660

tccgagtggc accctggatc atgacgccca gcactctgcc acccctagag gtgtatgtgt      720

gccgtgtgag gaacaacacg tgttttgtgg atgcggtggc agagctggcc aggaaggccg      780

gctgcaagct gaccatctgc ccacaggccg agaaccgcaa cgaccgctgg atccaggatg      840

agatggagct gggctacgtt caggcgccgc acaagaccct cccggtggtc tttgactccc      900

caaggaatgg ggaactgcag gatttccctt acaaaagaat cctgggtcca gattttggtt      960

acgtgactcg ggaaccacgc gacaggtctg tgagtggcct ggactccttt gggaacctgg     1020

aggtcagccc tccagtggtg gccaatggga aagagtaccc cctggggagg atcctcattg     1080

ggggcaacct gcctgggtca agtggccgca gggtcaccca ggtggtgcgg gacttcctcc     1140

atgcccagaa ggtgcagccc cccgtggagc tctttgtgga ctggttggcc gtgggccatg     1200

tggatgagtt tctgagcttt gtccctgccc ccgatgggaa gggcttccgg atgctcctgg     1260

ccagccctgg ggcctgcttc aagctcttcc aggaaaagca gaagtgtggc cacgggaggg     1320

ccctcctgtt ccagggggtt gttgatgatg agcaggtcaa gaccatctcc atcaaccagg     1380

tgctctccaa taaagacctc atcaactaca ataagtttgt gcagagctgc atcgactgga     1440

accgtgaggt gctgaagcgg gagctgggcc tggcagagtg tgacatcatt gacatcccac     1500

agctcttcaa gaccgagagg aaaaaagcaa cggccttctt ccctgacttg gtgaacatgc     1560

tggtgctggg gaagcacctg ggcatcccca agccctttgg gcccatcatc aatggctgct     1620

gctgcctgga ggagaaggtg cggtccctgc tggagccgct gggcctccac tgcaccttca     1680

ttgatgactt cactccatac cacatgctgc atggggaggt gcactgtggc accaatgtgt     1740

gcagaaagcc cttctctttc aagtggtgga acatggtgcc ctgagacagc tcccacccac     1800

catcctgtcc ccctggggcg ggcattggcc caggtggtgg agacagagac aggcccctga     1860

acgataagca ccaagagacc ccaaggctcc agatggaaca ctgagggtga ccgtccctct     1920

cagaagcctt ttccctggaa gtgtccatgc ctcacctgca acccatgtgg ttctcagact     1980

tgaatcttct cggcccccca aaaagaagga cctcatttct tatagcctct cctgtgattc     2040

aacacaaccc atggagatgt ccccttctca ctctgaaatc atccatttgg ggacaaatcc     2100

acattggggt ctagaaacat ccacgtatct catcagccat cttgtcctgt gcatcctaac     2160

agaggaagga tccatgattc tgctttggtc caattgcttc ctctctgcag aggaacaacc     2220

ctaaaaccag accactccac gcaggacagg caggagagat tcttcctaaa gcctccccca     2280

taaaaaggga gctgtggatc cacttagatc agggcggaac catctttcac ccggccaagc     2340

tcctgcccag atgttgaccc tcacccagcg tgagctgtca catagtagga gcttctagat     2400

gcatgtggaa gcaatgagag ttgtccctta gccttataaa ctccccatga tctgacatgc     2460

agaaatccag ccttgtccag aatcctcctg gaatttcttg gagacgaaag tatctggggg     2520

attgttgggt actagggaga ctgggtacaa gggtgaaaag tagttcccat aatacacatg     2580

gttgactatg gtgatccacc ttgtgatggt taatattagg tgtctggaga aggttgcttc     2640

attggccctg ggacttctct ctgcaggagg agagaacgct gcctctcctc tggattggtc     2700

tcaggctctc tgttggcctt tggtcagcgt ttccacatcc tgctctgctg caggagaggg     2760

ggctaagggg ctggatccac caaggcagct cacagcggga aaactctggg aatgaaccac     2820

tgaattcagg ggatgggggt gggggggcgg ttctcgaggt gtgtgccagc tacacgtgtg     2880

ttctgtatgg gtccagctgc gtttccatca ctcgctaata aatcaacaga aacacaaa       2938


<210>  38
<211>  485
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X2 [Homo sapiens]

<400>  38

Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp 
1               5                   10                  15      


Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala 
            20                  25                  30          


Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg 
        35                  40                  45              


His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His 
    50                  55                  60                  


Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala 
65                  70                  75                  80  


Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser 
                85                  90                  95      


Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe 
            100                 105                 110         


Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu 
        115                 120                 125             


Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val 
    130                 135                 140                 


Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln 
145                 150                 155                 160 


Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly 
                165                 170                 175     


Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro 
            180                 185                 190         


Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro 
        195                 200                 205             


Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly 
    210                 215                 220                 


Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro 
                245                 250                 255     


Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His 
            260                 265                 270         


Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala 
        275                 280                 285             


Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly 
    290                 295                 300                 


Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu 
305                 310                 315                 320 


Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln 
                325                 330                 335     


Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val 
            340                 345                 350         


Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys 
        355                 360                 365             


Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu 
    370                 375                 380                 


Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys 
385                 390                 395                 400 


Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys 
                405                 410                 415     


His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys 
            420                 425                 430         


Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His 
        435                 440                 445             


Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu 
    450                 455                 460                 


Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp 
465                 470                 475                 480 


Trp Asn Met Val Pro 
                485 


<210>  39
<211>  2938
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X2, mRNA

<400>  39
agaaatggat ggatgtgact gtgtgctaat aaaactttat ttatacaaac aggcagtagg       60

ccagatttgg cccacagttc ataatgtgct gatcctgacc taggcgagaa gagaaaccaa      120

atatgaaact gttgaagaac ttgggactga attatgttgg aacttggtgc cctgggagtt      180

aagaggagaa ggtcgagcgg cagtgggtct gggggcccag tgggtatggc ggcatcttgc      240

tggtgaactg tgaccgtgat gatccgagct gtgatgtcca ggacaattgt gaccagcacg      300

tgcactgcct gcaagacctg gaagacatgt ctgtcatggt cctgcggacg cagggccctg      360

cagccctctt tgatgaccac aaacttgtcc tccatacctc cagctatgat gccaaacggg      420

cacaggtctt ccacatctgc ggtcctgagg atgtgtgtga ggcctatagg catgtgctgg      480

gccaagataa ggtgtcctat gaggtacccc gcttgcatgg ggatgaggag cgcttcttcg      540

tggaaggcct gtccttccct gatgccggct tcacaggact catctccttc catgtcactc      600

tgctggacga ctccaacgag gatttctcgg catcccctat cttcactgac actgtggtgt      660

tccgagtggc accctggatc atgacgccca gcactctgcc acccctagag gtgtatgtgt      720

gccgtgtgag gaacaacacg tgttttgtgg atgcggtggc agagctggcc aggaaggccg      780

gctgcaagct gaccatctgc ccacaggccg agaaccgcaa cgaccgctgg atccaggatg      840

agatggagct gggctacgtt caggcgccgc acaagaccct cccggtggtc tttgactccc      900

caaggaatgg ggaactgcag gatttccctt acaaaagaat cctgggtcca gattttggtt      960

acgtgactcg ggaaccacgc gacaggtctg tgagtggcct ggactccttt gggaacctgg     1020

aggtcagccc tccagtggtg gccaatggga aagagtaccc cctggggagg atcctcattg     1080

ggggcaacct gcctgggtca agtggccgca gggtcaccca ggtggtgcgg gacttcctcc     1140

atgcccagaa ggtgcagccc cccgtggagc tctttgtgga ctggttggcc gtgggccatg     1200

tggatgagtt tctgagcttt gtccctgccc ccgatgggaa gggcttccgg atgctcctgg     1260

ccagccctgg ggcctgcttc aagctcttcc aggaaaagca gaagtgtggc cacgggaggg     1320

ccctcctgtt ccagggggtt gttgatgatg agcaggtcaa gaccatctcc atcaaccagg     1380

tgctctccaa taaagacctc atcaactaca ataagtttgt gcagagctgc atcgactgga     1440

accgtgaggt gctgaagcgg gagctgggcc tggcagagtg tgacatcatt gacatcccac     1500

agctcttcaa gaccgagagg aaaaaagcaa cggccttctt ccctgacttg gtgaacatgc     1560

tggtgctggg gaagcacctg ggcatcccca agccctttgg gcccatcatc aatggctgct     1620

gctgcctgga ggagaaggtg cggtccctgc tggagccgct gggcctccac tgcaccttca     1680

ttgatgactt cactccatac cacatgctgc atggggaggt gcactgtggc accaatgtgt     1740

gcagaaagcc cttctctttc aagtggtgga acatggtgcc ctgagacagc tcccacccac     1800

catcctgtcc ccctggggcg ggcattggcc caggtggtgg agacagagac aggcccctga     1860

acgataagca ccaagagacc ccaaggctcc agatggaaca ctgagggtga ccgtccctct     1920

cagaagcctt ttccctggaa gtgtccatgc ctcacctgca acccatgtgg ttctcagact     1980

tgaatcttct cggcccccca aaaagaagga cctcatttct tatagcctct cctgtgattc     2040

aacacaaccc atggagatgt ccccttctca ctctgaaatc atccatttgg ggacaaatcc     2100

acattggggt ctagaaacat ccacgtatct catcagccat cttgtcctgt gcatcctaac     2160

agaggaagga tccatgattc tgctttggtc caattgcttc ctctctgcag aggaacaacc     2220

ctaaaaccag accactccac gcaggacagg caggagagat tcttcctaaa gcctccccca     2280

taaaaaggga gctgtggatc cacttagatc agggcggaac catctttcac ccggccaagc     2340

tcctgcccag atgttgaccc tcacccagcg tgagctgtca catagtagga gcttctagat     2400

gcatgtggaa gcaatgagag ttgtccctta gccttataaa ctccccatga tctgacatgc     2460

agaaatccag ccttgtccag aatcctcctg gaatttcttg gagacgaaag tatctggggg     2520

attgttgggt actagggaga ctgggtacaa gggtgaaaag tagttcccat aatacacatg     2580

gttgactatg gtgatccacc ttgtgatggt taatattagg tgtctggaga aggttgcttc     2640

attggccctg ggacttctct ctgcaggagg agagaacgct gcctctcctc tggattggtc     2700

tcaggctctc tgttggcctt tggtcagcgt ttccacatcc tgctctgctg caggagaggg     2760

ggctaagggg ctggatccac caaggcagct cacagcggga aaactctggg aatgaaccac     2820

tgaattcagg ggatgggggt gggggggcgg ttctcgaggt gtgtgccagc tacacgtgtg     2880

ttctgtatgg gtccagctgc gtttccatca ctcgctaata aatcaacaga aacacaaa       2938


<210>  40
<211>  2938
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X2, mRNA

<400>  40
agaaatggat ggatgtgact gtgtgctaat aaaactttat ttatacaaac aggcagtagg       60

ccagatttgg cccacagttc ataatgtgct gatcctgacc taggcgagaa gagaaaccaa      120

atatgaaact gttgaagaac ttgggactga attatgttgg aacttggtgc cctgggagtt      180

aagaggagaa ggtcgagcgg cagtgggtct gggggcccag tgggtatggc ggcatcttgc      240

tggtgaactg tgaccgtgat gatccgagct gtgatgtcca ggacaattgt gaccagcacg      300

tgcactgcct gcaagacctg gaagacatgt ctgtcatggt cctgcggacg cagggccctg      360

cagccctctt tgatgaccac aaacttgtcc tccatacctc cagctatgat gccaaacggg      420

cacaggtctt ccacatctgc ggtcctgagg atgtgtgtga ggcctatagg catgtgctgg      480

gccaagataa ggtgtcctat gaggtacccc gcttgcatgg ggatgaggag cgcttcttcg      540

tggaaggcct gtccttccct gatgccggct tcacaggact catctccttc catgtcactc      600

tgctggacga ctccaacgag gatttctcgg catcccctat cttcactgac actgtggtgt      660

tccgagtggc accctggatc atgacgccca gcactctgcc acccctagag gtgtatgtgt      720

gccgtgtgag gaacaacacg tgttttgtgg atgcggtggc agagctggcc aggaaggccg      780

gctgcaagct gaccatctgc ccacaggccg agaaccgcaa cgaccgctgg atccaggatg      840

agatggagct gggctacgtt caggcgccgc acaagaccct cccggtggtc tttgactccc      900

caaggaatgg ggaactgcag gatttccctt acaaaagaat cctgggtcca gattttggtt      960

acgtgactcg ggaaccacgc gacaggtctg tgagtggcct ggactccttt gggaacctgg     1020

aggtcagccc tccagtggtg gccaatggga aagagtaccc cctggggagg atcctcattg     1080

ggggcaacct gcctgggtca agtggccgca gggtcaccca ggtggtgcgg gacttcctcc     1140

atgcccagaa ggtgcagccc cccgtggagc tctttgtgga ctggttggcc gtgggccatg     1200

tggatgagtt tctgagcttt gtccctgccc ccgatgggaa gggcttccgg atgctcctgg     1260

ccagccctgg ggcctgcttc aagctcttcc aggaaaagca gaagtgtggc cacgggaggg     1320

ccctcctgtt ccagggggtt gttgatgatg agcaggtcaa gaccatctcc atcaaccagg     1380

tgctctccaa taaagacctc atcaactaca ataagtttgt gcagagctgc atcgactgga     1440

accgtgaggt gctgaagcgg gagctgggcc tggcagagtg tgacatcatt gacatcccac     1500

agctcttcaa gaccgagagg aaaaaagcaa cggccttctt ccctgacttg gtgaacatgc     1560

tggtgctggg gaagcacctg ggcatcccca agccctttgg gcccatcatc aatggctgct     1620

gctgcctgga ggagaaggtg cggtccctgc tggagccgct gggcctccac tgcaccttca     1680

ttgatgactt cactccatac cacatgctgc atggggaggt gcactgtggc accaatgtgt     1740

gcagaaagcc cttctctttc aagtggtgga acatggtgcc ctgagacagc tcccacccac     1800

catcctgtcc ccctggggcg ggcattggcc caggtggtgg agacagagac aggcccctga     1860

acgataagca ccaagagacc ccaaggctcc agatggaaca ctgagggtga ccgtccctct     1920

cagaagcctt ttccctggaa gtgtccatgc ctcacctgca acccatgtgg ttctcagact     1980

tgaatcttct cggcccccca aaaagaagga cctcatttct tatagcctct cctgtgattc     2040

aacacaaccc atggagatgt ccccttctca ctctgaaatc atccatttgg ggacaaatcc     2100

acattggggt ctagaaacat ccacgtatct catcagccat cttgtcctgt gcatcctaac     2160

agaggaagga tccatgattc tgctttggtc caattgcttc ctctctgcag aggaacaacc     2220

ctaaaaccag accactccac gcaggacagg caggagagat tcttcctaaa gcctccccca     2280

taaaaaggga gctgtggatc cacttagatc agggcggaac catctttcac ccggccaagc     2340

tcctgcccag atgttgaccc tcacccagcg tgagctgtca catagtagga gcttctagat     2400

gcatgtggaa gcaatgagag ttgtccctta gccttataaa ctccccatga tctgacatgc     2460

agaaatccag ccttgtccag aatcctcctg gaatttcttg gagacgaaag tatctggggg     2520

attgttgggt actagggaga ctgggtacaa gggtgaaaag tagttcccat aatacacatg     2580

gttgactatg gtgatccacc ttgtgatggt taatattagg tgtctggaga aggttgcttc     2640

attggccctg ggacttctct ctgcaggagg agagaacgct gcctctcctc tggattggtc     2700

tcaggctctc tgttggcctt tggtcagcgt ttccacatcc tgctctgctg caggagaggg     2760

ggctaagggg ctggatccac caaggcagct cacagcggga aaactctggg aatgaaccac     2820

tgaattcagg ggatgggggt gggggggcgg ttctcgaggt gtgtgccagc tacacgtgtg     2880

ttctgtatgg gtccagctgc gtttccatca ctcgctaata aatcaacaga aacacaaa       2938


<210>  41
<211>  2938
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X2, mRNA

<400>  41
agaaatggat ggatgtgact gtgtgctaat aaaactttat ttatacaaac aggcagtagg       60

ccagatttgg cccacagttc ataatgtgct gatcctgacc taggcgagaa gagaaaccaa      120

atatgaaact gttgaagaac ttgggactga attatgttgg aacttggtgc cctgggagtt      180

aagaggagaa ggtcgagcgg cagtgggtct gggggcccag tgggtatggc ggcatcttgc      240

tggtgaactg tgaccgtgat gatccgagct gtgatgtcca ggacaattgt gaccagcacg      300

tgcactgcct gcaagacctg gaagacatgt ctgtcatggt cctgcggacg cagggccctg      360

cagccctctt tgatgaccac aaacttgtcc tccatacctc cagctatgat gccaaacggg      420

cacaggtctt ccacatctgc ggtcctgagg atgtgtgtga ggcctatagg catgtgctgg      480

gccaagataa ggtgtcctat gaggtacccc gcttgcatgg ggatgaggag cgcttcttcg      540

tggaaggcct gtccttccct gatgccggct tcacaggact catctccttc catgtcactc      600

tgctggacga ctccaacgag gatttctcgg catcccctat cttcactgac actgtggtgt      660

tccgagtggt accctggatc atgacgccca gcactctgcc acccctagag gtgtatgtgt      720

gccgtgtgag gaacaacacg tgttttgtgg atgcggtggc agagctggcc aggaaggccg      780

gctgcaagct gaccatctgc ccacaggccg agaaccgcaa cgaccgctgg atccaggatg      840

agatggagct gggctacgtt caggcgccgc acaagaccct cccggtggtc tttgactccc      900

caaggaatgg ggaactgcag gatttccctt acaaaagaat cctgggtcca gattttggtt      960

acgtgactcg ggaaccacgc gacaggtctg tgagtggcct ggactccttt gggaacctgg     1020

aggtcagccc tccagtggtg gccaatggga aagagtaccc cctggggagg atcctcattg     1080

ggggcaacct gcctgggtca agtggccgca gggtcaccca ggtggtgcgg gacttcctcc     1140

atgcccagaa ggtgcagccc cccgtggagc tctttgtgga ctggttggcc gtgggccatg     1200

tggatgagtt tctgagcttt gtccctgccc ccgatgggaa gggcttccgg atgctcctgg     1260

ccagccctgg ggcctgcttc aagctcttcc aggaaaagca gaagtgtggc cacgggaggg     1320

ccctcctgtt ccagggggtt gttgatgatg agcaggtcaa gaccatctcc atcaaccagg     1380

tgctctccaa taaagacctc atcaactaca ataagtttgt gcagagctgc atcgactgga     1440

accgtgaggt gctgaagcgg gagctgggcc tggcagagtg tgacatcatt gacatcccac     1500

agctcttcaa gaccgagagg aaaaaagcaa cggccttctt ccctgacttg gtgaacatgc     1560

tggtgctggg gaagcacctg ggcatcccca agccctttgg gcccatcatc aatggctgct     1620

gctgcctgga ggagaaggtg cggtccctgc tggagccgct gggcctccac tgcaccttca     1680

ttgatgactt cactccatac cacatgctgc atggggaggt gcactgtggc accaatgtgt     1740

gcagaaagcc cttctctttc aagtggtgga acatggtgcc ctgagacagc tcccacccac     1800

catcctgtcc ccctggggcg ggcattggcc caggtggtgg agacagagac aggcccctga     1860

acgataagca ccaagagacc ccaaggctcc agatggaaca ctgagggtga ccgtccctct     1920

cagaagcctt ttccctggaa gtgtccatgc ctcacctgca acccatgtgg ttctcagact     1980

tgaatcttct cggcccccca aaaagaagga cctcatttct tatagcctct cctgtgattc     2040

aacacaaccc atggagatgt ccccttctca ctctgaaatc atccatttgg ggacaaatcc     2100

acattggggt ctagaaacat ccacgtatct catcagccat cttgtcctgt gcatcctaac     2160

agaggaagga tccatgattc tgctttggtc caattgcttc ctctctgcag aggaacaacc     2220

ctaaaaccag accactccac gcaggacagg caggagagat tcttcctaaa gcctccccca     2280

taaaaaggga gctgtggatc cacttagatc agggcggaac catctttcac ccggccaagc     2340

tcctgcccag atgttgaccc tcacccagcg tgagctgtca catagtagga gcttctagat     2400

gcatgtggaa gcaatgagag ttgtccctta gccttataaa ctccccatga tctgacatgc     2460

agaaatccag ccttgtccag aatcctcctg gaatttcttg gagacgaaag tatctggggg     2520

attgttgggt actagggaga ctgggtacaa gggtgaaaag tagttcccat aatacacatg     2580

gttgactatg gtgatccacc ttgtgatggt taatattagg tgtctggaga aggttgcttc     2640

attggccctg ggacttctct ctgcaggagg agagaacgct gcctctcctc tggattggtc     2700

tcaggctctc tgttggcctt tggtcagcgt ttccacatcc tgctctgctg caggagaggg     2760

ggctaagggg ctggatccac caaggcagct cacagcggga aaactctggg aatgaaccac     2820

tgaattcagg ggatgggggt gggggggcgg ttctcgaggt gtgtgccagc tacacgtgtg     2880

ttctgtatgg gtccagctgc gtttccatca ctcgctaata aatcaacaga aacacaaa       2938


<210>  42
<211>  485
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X2 [Homo sapiens]

<400>  42

Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp 
1               5                   10                  15      


Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala 
            20                  25                  30          


Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg 
        35                  40                  45              


His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His 
    50                  55                  60                  


Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala 
65                  70                  75                  80  


Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser 
                85                  90                  95      


Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe 
            100                 105                 110         


Arg Val Val Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu 
        115                 120                 125             


Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val 
    130                 135                 140                 


Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln 
145                 150                 155                 160 


Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly 
                165                 170                 175     


Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro 
            180                 185                 190         


Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro 
        195                 200                 205             


Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly 
    210                 215                 220                 


Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro 
                245                 250                 255     


Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His 
            260                 265                 270         


Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala 
        275                 280                 285             


Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly 
    290                 295                 300                 


Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu 
305                 310                 315                 320 


Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln 
                325                 330                 335     


Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val 
            340                 345                 350         


Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys 
        355                 360                 365             


Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu 
    370                 375                 380                 


Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys 
385                 390                 395                 400 


Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys 
                405                 410                 415     


His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys 
            420                 425                 430         


Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His 
        435                 440                 445             


Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu 
    450                 455                 460                 


Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp 
465                 470                 475                 480 


Trp Asn Met Val Pro 
                485 


<210>  43
<211>  2938
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X2, mRNA

<400>  43
agaaatggat ggatgtgact gtgtgctaat aaaactttat ttatacaaac aggcagtagg       60

ccagatttgg cccacagttc ataatgtgct gatcctgacc taggcgagaa gagaaaccaa      120

atatgaaact gttgaagaac ttgggactga attatgttgg aacttggtgc cctgggagtt      180

aagaggagaa ggtcgagcgg cagtgggtct gggggcccag tgggtatggc ggcatcttgc      240

tggtgaactg tgaccgtgat gatccgagct gtgatgtcca ggacaattgt gaccagcacg      300

tgcactgcct gcaagacctg gaagacatgt ctgtcatggt cctgcggacg cagggccctg      360

cagccctctt tgatgaccac aaacttgtcc tccatacctc cagctatgat gccaaacggg      420

cacaggtctt ccacatctgc ggtcctgagg atgtgtgtga ggcctatagg catgtgctgg      480

gccaagataa ggtgtcctat gaggtacccc gcttgcatgg ggatgaggag cgcttcttcg      540

tggaaggcct gtccttccct gatgccggct tcacaggact catctccttc catgtcactc      600

tgctggacga ctccaacgag gatttctcgg catcccctat cttcactgac actgtggtgt      660

tccgagtggc accctggatc atgacgccca gcactctgcc acccctagag gtgtatgtgt      720

gccgtgtgag gaacaacacg tgttttgtgg atgcggtggc agagctggcc aggaaggccg      780

gctgcaagct gaccatctgc ccacaggccg agaaccgcaa cgaccgctgg atccaggatg      840

agatggagct gggctacgtt caggcgccgc acaagaccct cccggtggtc tttgactccc      900

caaggaatgg ggaactgcag gatttccctt acaaaagaat cctgggtcca gattttggtt      960

acgtgactcg ggaaccacgc gacaggtctg tgagtggcct ggactccttt gggaacctgg     1020

aggtcagccc tccagtggtg gccaatggga aagagtaccc cctggggagg atcctcattg     1080

ggggcaacct gcctgggtca agtggccgca gggtcaccca ggtggtgcgg gacttcctcc     1140

atgcccagaa ggtgcagccc cccgtggagc tctttgtgga ctggttggcc gtgggccatg     1200

tggatgagtt tctgagcttt gtccctgccc ccgatgggaa gggcttccgg atgctcctgg     1260

ccagccctgg ggcctgcttc aagctcttcc aggaaaagca gaagtgtggc cacgggaggg     1320

ccctcctgtt ccagggggtt gttgatgatg agcaggtcaa gaccatctcc atcaaccagg     1380

tgctctccaa taaagacctc atcaactaca ataagtttgt gcagagctgc atcgactgga     1440

accgtgaggt gctgaagcgg gagctgggcc tggcagagtg tgacatcatt gacatcccac     1500

agctcttcaa gaccgagagg aaaaaagcaa cgaccttctt ccctgacttg gtgaacatgc     1560

tggtgctggg gaagcacctg ggcatcccca agccctttgg gcccatcatc aatggctgct     1620

gctgcctgga ggagaaggtg cggtccctgc tggagccgct gggcctccac tgcaccttca     1680

ttgatgactt cactccatac cacatgctgc atggggaggt gcactgtggc accaatgtgt     1740

gcagaaagcc cttctctttc aagtggtgga acatggtgcc ctgagacagc tcccacccac     1800

catcctgtcc ccctggggcg ggcattggcc caggtggtgg agacagagac aggcccctga     1860

acgataagca ccaagagacc ccaaggctcc agatggaaca ctgagggtga ccgtccctct     1920

cagaagcctt ttccctggaa gtgtccatgc ctcacctgca acccatgtgg ttctcagact     1980

tgaatcttct cggcccccca aaaagaagga cctcatttct tatagcctct cctgtgattc     2040

aacacaaccc atggagatgt ccccttctca ctctgaaatc atccatttgg ggacaaatcc     2100

acattggggt ctagaaacat ccacgtatct catcagccat cttgtcctgt gcatcctaac     2160

agaggaagga tccatgattc tgctttggtc caattgcttc ctctctgcag aggaacaacc     2220

ctaaaaccag accactccac gcaggacagg caggagagat tcttcctaaa gcctccccca     2280

taaaaaggga gctgtggatc cacttagatc agggcggaac catctttcac ccggccaagc     2340

tcctgcccag atgttgaccc tcacccagcg tgagctgtca catagtagga gcttctagat     2400

gcatgtggaa gcaatgagag ttgtccctta gccttataaa ctccccatga tctgacatgc     2460

agaaatccag ccttgtccag aatcctcctg gaatttcttg gagacgaaag tatctggggg     2520

attgttgggt actagggaga ctgggtacaa gggtgaaaag tagttcccat aatacacatg     2580

gttgactatg gtgatccacc ttgtgatggt taatattagg tgtctggaga aggttgcttc     2640

attggccctg ggacttctct ctgcaggagg agagaacgct gcctctcctc tggattggtc     2700

tcaggctctc tgttggcctt tggtcagcgt ttccacatcc tgctctgctg caggagaggg     2760

ggctaagggg ctggatccac caaggcagct cacagcggga aaactctggg aatgaaccac     2820

tgaattcagg ggatgggggt gggggggcgg ttctcgaggt gtgtgccagc tacacgtgtg     2880

ttctgtatgg gtccagctgc gtttccatca ctcgctaata aatcaacaga aacacaaa       2938


<210>  44
<211>  485
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X2 [Homo sapiens]

<400>  44

Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp 
1               5                   10                  15      


Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala 
            20                  25                  30          


Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg 
        35                  40                  45              


His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His 
    50                  55                  60                  


Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala 
65                  70                  75                  80  


Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser 
                85                  90                  95      


Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe 
            100                 105                 110         


Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu 
        115                 120                 125             


Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val 
    130                 135                 140                 


Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln 
145                 150                 155                 160 


Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly 
                165                 170                 175     


Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro 
            180                 185                 190         


Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro 
        195                 200                 205             


Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly 
    210                 215                 220                 


Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro 
                245                 250                 255     


Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His 
            260                 265                 270         


Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala 
        275                 280                 285             


Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly 
    290                 295                 300                 


Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu 
305                 310                 315                 320 


Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln 
                325                 330                 335     


Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val 
            340                 345                 350         


Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys 
        355                 360                 365             


Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu 
    370                 375                 380                 


Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys 
385                 390                 395                 400 


Ala Thr Thr Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys 
                405                 410                 415     


His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys 
            420                 425                 430         


Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His 
        435                 440                 445             


Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu 
    450                 455                 460                 


Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp 
465                 470                 475                 480 


Trp Asn Met Val Pro 
                485 


<210>  45
<211>  2938
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X2, mRNA

<400>  45
agaaatggat ggatgtgact gtgtgctaat aaaactttat ttatacaaac aggcagtagg       60

ccagatttgg cccacagttc ataatgtgct gatcctgacc taggcgagaa gagaaaccaa      120

atatgaaact gttgaagaac ttgggactga attatgttgg aacttggtgc cctgggagtt      180

aagaggagaa ggtcgagcgg cagtgggtct gggggcccag tgggtatggc ggcatcttgc      240

tggtgaactg tgaccgtgat gatccgagct gtgatgtcca ggacaattgt gaccagcacg      300

tgcactgcct gcaagacctg gaagacatgt ctgtcatggt cctgcggacg cagggccctg      360

cagccctctt tgatgaccac aaacttgtcc tccatacctc cagctatgat gccaaacggg      420

cacaggtctt ccacatctgc ggtcctgagg atgtgtgtga ggcctatagg catgtgctgg      480

gccaagataa ggtgtcctat gaggtacccc gcttgcatgg ggatgaggag cgcttcttcg      540

tggaaggcct gtccttccct gatgccggct tcacaggact catctccttc catgtcactc      600

tgctggacga ctccaacgag gatttctcgg catcccctat cttcactgac actgtggtgt      660

tccgagtggc accctggatc atgacgccca gcactctgcc acccctagag gtgtatgtgt      720

gccgtgtgag gaacaacacg tgttttgtgg atgcggtggc agagctggcc aggaaggccg      780

gctgcaagct gaccatctgc ccacaggccg agaaccgcaa cgaccgctgg atccaggatg      840

agatggagct gggctacgtt caggcgccgc acaagaccct cccggtggtc tttgactccc      900

caaggaatgg ggaactgcag gatttccctt acaaaagaat cctgggtcca gattttggtt      960

acgtgactcg ggaaccacgc gacaggtctg tgagtggcct ggactccttt gggaacctgg     1020

aggtcagccc tccagtggtg gccaatggga aagagtaccc cctggggagg atcctcattg     1080

ggggcaacct gcctgggtca agtggccgca gggtcaccca ggtggtgcgg gacttcctcc     1140

atgcccagaa ggtgcagccc cccgtggagc tctttgtgga ctggttggcc gtgggccatg     1200

tggatgagtt tctgagcttt gtccctgccc ccgatgggaa gggcttccgg atgctcctgg     1260

ccagccctgg ggcctgcttc aagctcttcc aggaaaagca gaagtgtggc cacgggaggg     1320

ccctcctgtt ccagggggtt gttgatgatg agcaggtcaa gaccatctcc atcaaccagg     1380

tgctctccaa taaagacctc atcaactaca ataagtttgt gcagagctgc atcgactgga     1440

accgtgaggt gctgaagcgg gagctgggcc tggcagagtg tgacatcatt gacatcccac     1500

agctcttcaa gaccgagagg aaaaaagcaa cggccttctt ccctgacttg gtgaacatgc     1560

tggtgctggg gaagcacctg ggcatcccca agccctttgg gaccatcatc aatggctgct     1620

gctgcctgga ggagaaggtg cggtccctgc tggagccgct gggcctccac tgcaccttca     1680

ttgatgactt cactccatac cacatgctgc atggggaggt gcactgtggc accaatgtgt     1740

gcagaaagcc cttctctttc aagtggtgga acatggtgcc ctgagacagc tcccacccac     1800

catcctgtcc ccctggggcg ggcattggcc caggtggtgg agacagagac aggcccctga     1860

acgataagca ccaagagacc ccaaggctcc agatggaaca ctgagggtga ccgtccctct     1920

cagaagcctt ttccctggaa gtgtccatgc ctcacctgca acccatgtgg ttctcagact     1980

tgaatcttct cggcccccca aaaagaagga cctcatttct tatagcctct cctgtgattc     2040

aacacaaccc atggagatgt ccccttctca ctctgaaatc atccatttgg ggacaaatcc     2100

acattggggt ctagaaacat ccacgtatct catcagccat cttgtcctgt gcatcctaac     2160

agaggaagga tccatgattc tgctttggtc caattgcttc ctctctgcag aggaacaacc     2220

ctaaaaccag accactccac gcaggacagg caggagagat tcttcctaaa gcctccccca     2280

taaaaaggga gctgtggatc cacttagatc agggcggaac catctttcac ccggccaagc     2340

tcctgcccag atgttgaccc tcacccagcg tgagctgtca catagtagga gcttctagat     2400

gcatgtggaa gcaatgagag ttgtccctta gccttataaa ctccccatga tctgacatgc     2460

agaaatccag ccttgtccag aatcctcctg gaatttcttg gagacgaaag tatctggggg     2520

attgttgggt actagggaga ctgggtacaa gggtgaaaag tagttcccat aatacacatg     2580

gttgactatg gtgatccacc ttgtgatggt taatattagg tgtctggaga aggttgcttc     2640

attggccctg ggacttctct ctgcaggagg agagaacgct gcctctcctc tggattggtc     2700

tcaggctctc tgttggcctt tggtcagcgt ttccacatcc tgctctgctg caggagaggg     2760

ggctaagggg ctggatccac caaggcagct cacagcggga aaactctggg aatgaaccac     2820

tgaattcagg ggatgggggt gggggggcgg ttctcgaggt gtgtgccagc tacacgtgtg     2880

ttctgtatgg gtccagctgc gtttccatca ctcgctaata aatcaacaga aacacaaa       2938


<210>  46
<211>  485
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X2 [Homo sapiens]

<400>  46

Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp 
1               5                   10                  15      


Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala 
            20                  25                  30          


Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg 
        35                  40                  45              


His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His 
    50                  55                  60                  


Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala 
65                  70                  75                  80  


Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser 
                85                  90                  95      


Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe 
            100                 105                 110         


Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu 
        115                 120                 125             


Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val 
    130                 135                 140                 


Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln 
145                 150                 155                 160 


Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly 
                165                 170                 175     


Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro 
            180                 185                 190         


Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro 
        195                 200                 205             


Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly 
    210                 215                 220                 


Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro 
                245                 250                 255     


Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His 
            260                 265                 270         


Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala 
        275                 280                 285             


Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly 
    290                 295                 300                 


Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu 
305                 310                 315                 320 


Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln 
                325                 330                 335     


Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val 
            340                 345                 350         


Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys 
        355                 360                 365             


Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu 
    370                 375                 380                 


Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys 
385                 390                 395                 400 


Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys 
                405                 410                 415     


His Leu Gly Ile Pro Lys Pro Phe Gly Thr Ile Ile Asn Gly Cys Cys 
            420                 425                 430         


Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu Gly Leu His 
        435                 440                 445             


Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu 
    450                 455                 460                 


Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp 
465                 470                 475                 480 


Trp Asn Met Val Pro 
                485 


<210>  47
<211>  2938
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X2, mRNA

<400>  47
agaaatggat ggatgtgact gtgtgctaat aaaactttat ttatacaaac aggcagtagg       60

ccagatttgg cccacagttc ataatgtgct gatcctgacc taggcgagaa gagaaaccaa      120

atatgaaact gttgaagaac ttgggactga attatgttgg aacttggtgc cctgggagtt      180

aagaggagaa ggtcgagcgg cagtgggtct gggggcccag tgggtatggc ggcatcttgc      240

tggtgaactg tgaccgtgat gatccgagct gtgatgtcca ggacaattgt gaccagcacg      300

tgcactgcct gcaagacctg gaagacatgt ctgtcatggt cctgcggacg cagggccctg      360

cagccctctt tgatgaccac aaacttgtcc tccatacctc cagctatgat gccaaacggg      420

cacaggtctt ccacatctgc ggtcctgagg atgtgtgtga ggcctatagg catgtgctgg      480

gccaagataa ggtgtcctat gaggtacccc gcttgcatgg ggatgaggag cgcttcttcg      540

tggaaggcct gtccttccct gatgccggct tcacaggact catctccttc catgtcactc      600

tgctggacga ctccaacgag gatttctcgg catcccctat cttcactgac actgtggtgt      660

tccgagtggc accctggatc atgacgccca gcactctgcc acccctagag gtgtatgtgt      720

gccgtgtgag gaacaacacg tgttttgtgg atgcggtggc agagctggcc aggaaggccg      780

gctgcaagct gaccatctgc ccacaggccg agaaccgcaa cgaccgctgg atccaggatg      840

agatggagct gggctacgtt caggcgccgc acaagaccct cccggtggtc tttgactccc      900

caaggaatgg ggaactgcag gatttccctt acaaaagaat cctgggtcca gattttggtt      960

acgtgactcg ggaaccacgc gacaggtctg tgagtggcct ggactccttt gggaacctgg     1020

aggtcagccc tccagtggtg gccaatggga aagagtaccc cctggggagg atcctcattg     1080

ggggcaacct gcctgggtca agtggccgca gggtcaccca ggtggtgcgg gacttcctcc     1140

atgcccagaa ggtgcagccc cccgtggagc tctttgtgga ctggttggcc gtgggccatg     1200

tggatgagtt tctgagcttt gtccctgccc ccgatgggaa gggcttccgg atgctcctgg     1260

ccagccctgg ggcctgcttc aagctcttcc aggaaaagca gaagtgtggc cacgggaggg     1320

ccctcctgtt ccagggggtt gttgatgatg agcaggtcaa gaccatctcc atcaaccagg     1380

tgctctccaa taaagacctc atcaactaca ataagtttgt gcagagctgc atcgactgga     1440

accgtgaggt gctgaagcgg gagctgggcc tggcagagtg tgacatcatt gacatcccac     1500

agctcttcaa gaccgagagg aaaaaagcaa cggccttctt ccctgacttg gtgaacatgc     1560

tggtgctggg gaagcacctg ggcatcccca agccctttgg gcccatcatc aatggctgct     1620

gctgcctgga ggagaaggtg cagtccctgc tggagccgct gggcctccac tgcaccttca     1680

ttgatgactt cactccatac cacatgctgc atggggaggt gcactgtggc accaatgtgt     1740

gcagaaagcc cttctctttc aagtggtgga acatggtgcc ctgagacagc tcccacccac     1800

catcctgtcc ccctggggcg ggcattggcc caggtggtgg agacagagac aggcccctga     1860

acgataagca ccaagagacc ccaaggctcc agatggaaca ctgagggtga ccgtccctct     1920

cagaagcctt ttccctggaa gtgtccatgc ctcacctgca acccatgtgg ttctcagact     1980

tgaatcttct cggcccccca aaaagaagga cctcatttct tatagcctct cctgtgattc     2040

aacacaaccc atggagatgt ccccttctca ctctgaaatc atccatttgg ggacaaatcc     2100

acattggggt ctagaaacat ccacgtatct catcagccat cttgtcctgt gcatcctaac     2160

agaggaagga tccatgattc tgctttggtc caattgcttc ctctctgcag aggaacaacc     2220

ctaaaaccag accactccac gcaggacagg caggagagat tcttcctaaa gcctccccca     2280

taaaaaggga gctgtggatc cacttagatc agggcggaac catctttcac ccggccaagc     2340

tcctgcccag atgttgaccc tcacccagcg tgagctgtca catagtagga gcttctagat     2400

gcatgtggaa gcaatgagag ttgtccctta gccttataaa ctccccatga tctgacatgc     2460

agaaatccag ccttgtccag aatcctcctg gaatttcttg gagacgaaag tatctggggg     2520

attgttgggt actagggaga ctgggtacaa gggtgaaaag tagttcccat aatacacatg     2580

gttgactatg gtgatccacc ttgtgatggt taatattagg tgtctggaga aggttgcttc     2640

attggccctg ggacttctct ctgcaggagg agagaacgct gcctctcctc tggattggtc     2700

tcaggctctc tgttggcctt tggtcagcgt ttccacatcc tgctctgctg caggagaggg     2760

ggctaagggg ctggatccac caaggcagct cacagcggga aaactctggg aatgaaccac     2820

tgaattcagg ggatgggggt gggggggcgg ttctcgaggt gtgtgccagc tacacgtgtg     2880

ttctgtatgg gtccagctgc gtttccatca ctcgctaata aatcaacaga aacacaaa       2938


<210>  48
<211>  485
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X2 [Homo sapiens]

<400>  48

Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala Leu Phe Asp 
1               5                   10                  15      


Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala Lys Arg Ala 
            20                  25                  30          


Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu Ala Tyr Arg 
        35                  40                  45              


His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro Arg Leu His 
    50                  55                  60                  


Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe Pro Asp Ala 
65                  70                  75                  80  


Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu Asp Asp Ser 
                85                  90                  95      


Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr Val Val Phe 
            100                 105                 110         


Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro Pro Leu Glu 
        115                 120                 125             


Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val Asp Ala Val 
    130                 135                 140                 


Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile Cys Pro Gln 
145                 150                 155                 160 


Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met Glu Leu Gly 
                165                 170                 175     


Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro 
            180                 185                 190         


Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile Leu Gly Pro 
        195                 200                 205             


Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser Val Ser Gly 
    210                 215                 220                 


Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val Val Ala Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly Asn Leu Pro 
                245                 250                 255     


Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp Phe Leu His 
            260                 265                 270         


Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp Trp Leu Ala 
        275                 280                 285             


Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala Pro Asp Gly 
    290                 295                 300                 


Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys Phe Lys Leu 
305                 310                 315                 320 


Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu Leu Phe Gln 
                325                 330                 335     


Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile Asn Gln Val 
            340                 345                 350         


Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val Gln Ser Cys 
        355                 360                 365             


Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly Leu Ala Glu 
    370                 375                 380                 


Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu Arg Lys Lys 
385                 390                 395                 400 


Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val Leu Gly Lys 
                405                 410                 415     


His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn Gly Cys Cys 
            420                 425                 430         


Cys Leu Glu Glu Lys Val Gln Ser Leu Leu Glu Pro Leu Gly Leu His 
        435                 440                 445             


Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu His Gly Glu 
    450                 455                 460                 


Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser Phe Lys Trp 
465                 470                 475                 480 


Trp Asn Met Val Pro 
                485 


<210>  49
<211>  1452
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X3, mRNA

<400>  49
cctaaggggc ctcaggggca gtgttggggt tggcggccac agctaagtcc aacaccagca       60

tgtcgctgca gagaatcgtg cgtgtgtccc tggagcatcc caccagcgcg gtgtgtgtgg      120

ctggcgtgga gaccctcgtg gacatttatg ggtcagtgcc tgagggcaca gaaatgtttg      180

aggtctatgg gacgcctggc gtggacatct acatctctcc caacatggag aggggccggg      240

agcgtgcaga caccaggcgg tggcgctttg acgcgacttt ggagatcatc gtggtcatga      300

actcccccag caatgacctc aacgacagcc atgttcagat ttcctaccac tccagccatg      360

agcctctgcc cctggcctat gcggtgctct acctcacctg tgttgacatc tctctggatt      420

gcgacctgaa ctgtgaggga aggcaggaca ggaactttgt agacaagcgg cagtgggtct      480

gggggcccag tgggtatggc ggcatcttgc tggtgaactg tgaccgtgat gatccgagct      540

gtgatgtcca ggacaattgt gaccagcacg tgcactgcct gcaagacctg gaagacatgt      600

ctgtcatggt cctgcggacg cagggccctg cagccctctt tgatgaccac aaacttgtcc      660

tccatacctc cagctatgat gccaaacggg cacaggtctt ccacatctgc ggtcctgagg      720

atgtgtgtga ggcctatagg catgtgctgg gccaagataa ggtgtcctat gaggtacccc      780

gcttgcatgg ggatgaggag cgcttcttcg tggaaggcct gtccttccct gatgccggct      840

tcacaggact catctccttc catgtcactc tgctggacga ctccaacgag gatttctcgg      900

catcccctat cttcactgac actgtggtgt tccgagtggc accctggatc atgacgccca      960

gcactctgcc acccctagag gtgtatgtgt gccgtgtgag gaacaacacg tgttttgtgg     1020

atgcggtggc agagctggcc aggaaggccg gctgcaagct gaccatctgc ccacaggccg     1080

agaaccgcaa cgaccgctgg atccaggatg agatggagct gggctacgtt caggcgccgc     1140

acaagaccct cccggtggtc tttgactccc caaggaatgg ggaactgcag gatttccctt     1200

acaaaagaat cctggtcaag tggccgcagg gtcacccagg tggtgcggga cttcctccat     1260

gcccagaagg tgcagccccc cgtggagctc tttgtggact ggttggccgt gggccatgtg     1320

gatgagtttc tgagctttgt ccctgccccc gatgggaagg gcttccggat gctcctggcc     1380

agccctgggg cctgcttcaa gctcttccag gaaaagcaga agtgtggcca cgggagggcc     1440

ctcctgttcc ag                                                         1452


<210>  50
<211>  421
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X3 [Homo sapiens]

<400>  50

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Val Lys Trp Pro Gln Gly His Pro Gly Gly Ala Gly Leu Pro Pro 
385                 390                 395                 400 


Cys Pro Glu Gly Ala Ala Pro Arg Gly Ala Leu Cys Gly Leu Val Gly 
                405                 410                 415     


Arg Gly Pro Cys Gly 
            420     


<210>  51
<211>  1452
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X3, mRNA

<400>  51
cctaaggggc ctcaggggca gtgttggggt tggcggccac agctaagtcc aacaccagca       60

tgtcgctgca gagaatcgtg cgtgtgtccc tggagcatcc caccagcgcg gtgtgtgtgg      120

ctggcgtgga gaccctcgtg gacatttatg ggtcagtgcc tgagggcaca gaaatgtttg      180

aggtctatgg gacgcctggc gtggacatct acgtctctcc caacatggag aggggccggg      240

agcgtgcaga caccaggcgg tggcgctttg acgcgacttt ggagatcatc gtggtcatga      300

actcccccag caatgacctc aacgacagcc atgttcagat ttcctaccac tccagccatg      360

agcctctgcc cctggcctat gcggtgctct acctcacctg tgttgacatc tctctggatt      420

gcgacctgaa ctgtgaggga aggcaggaca ggaactttgt agacaagcgg cagtgggtct      480

gggggcccag tgggtatggc ggcatcttgc tggtgaactg tgaccgtgat gatccgagct      540

gtgatgtcca ggacaattgt gaccagcacg tgcactgcct gcaagacctg gaagacatgt      600

ctgtcatggt cctgcggacg cagggccctg cagccctctt tgatgaccac aaacttgtcc      660

tccatacctc cagctatgat gccaaacggg cacaggtctt ccacatctgc ggtcctgagg      720

atgtgtgtga ggcctatagg catgtgctgg gccaagataa ggtgtcctat gaggtacccc      780

gcttgcatgg ggatgaggag cgcttcttcg tggaaggcct gtccttccct gatgccggct      840

tcacaggact catctccttc catgtcactc tgctggacga ctccaacgag gatttctcgg      900

catcccctat cttcactgac actgtggtgt tccgagtggc accctggatc atgacgccca      960

gcactctgcc acccctagag gtgtatgtgt gccgtgtgag gaacaacacg tgttttgtgg     1020

atgcggtggc agagctggcc aggaaggccg gctgcaagct gaccatctgc ccacaggccg     1080

agaaccgcaa cgaccgctgg atccaggatg agatggagct gggctacgtt caggcgccgc     1140

acaagaccct cccggtggtc tttgactccc caaggaatgg ggaactgcag gatttccctt     1200

acaaaagaat cctggtcaag tggccgcagg gtcacccagg tggtgcggga cttcctccat     1260

gcccagaagg tgcagccccc cgtggagctc tttgtggact ggttggccgt gggccatgtg     1320

gatgagtttc tgagctttgt ccctgccccc gatgggaagg gcttccggat gctcctggcc     1380

agccctgggg cctgcttcaa gctcttccag gaaaagcaga agtgtggcca cgggagggcc     1440

ctcctgttcc ag                                                         1452


<210>  52
<211>  421
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X3 [Homo sapiens]

<400>  52

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Val Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Val Lys Trp Pro Gln Gly His Pro Gly Gly Ala Gly Leu Pro Pro 
385                 390                 395                 400 


Cys Pro Glu Gly Ala Ala Pro Arg Gly Ala Leu Cys Gly Leu Val Gly 
                405                 410                 415     


Arg Gly Pro Cys Gly 
            420     


<210>  53
<211>  1452
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X3, mRNA

<400>  53
cctaaggggc ctcaggggca gtgttggggt tggcggccac agctaagtcc aacaccagca       60

tgtcgctgca gagaatcgtg cgtgtgtccc tggagcatcc caccagcgcg gtgtgtgtgg      120

ctggcgtgga gaccctcgtg gacatttatg ggtcagtgcc tgagggcaca gaaatgtttg      180

aggtctatgg gacgcctggc gtggacatct acatctctcc caacatggag aggggccggg      240

agcgtgcaga caccaggcgg tggcgctttg acgcgacttt ggagatcatc gtggtcatga      300

actcccccag caatgacctc aacgacagcc atgttcagat ttcctaccac tccagccatg      360

agcctctgcc cctggcctat gcggtgctct accacacctg tgttgacatc tctctggatt      420

gcgacctgaa ctgtgaggga aggcaggaca ggaactttgt agacaagcgg cagtgggtct      480

gggggcccag tgggtatggc ggcatcttgc tggtgaactg tgaccgtgat gatccgagct      540

gtgatgtcca ggacaattgt gaccagcacg tgcactgcct gcaagacctg gaagacatgt      600

ctgtcatggt cctgcggacg cagggccctg cagccctctt tgatgaccac aaacttgtcc      660

tccatacctc cagctatgat gccaaacggg cacaggtctt ccacatctgc ggtcctgagg      720

atgtgtgtga ggcctatagg catgtgctgg gccaagataa ggtgtcctat gaggtacccc      780

gcttgcatgg ggatgaggag cgcttcttcg tggaaggcct gtccttccct gatgccggct      840

tcacaggact catctccttc catgtcactc tgctggacga ctccaacgag gatttctcgg      900

catcccctat cttcactgac actgtggtgt tccgagtggc accctggatc atgacgccca      960

gcactctgcc acccctagag gtgtatgtgt gccgtgtgag gaacaacacg tgttttgtgg     1020

atgcggtggc agagctggcc aggaaggccg gctgcaagct gaccatctgc ccacaggccg     1080

agaaccgcaa cgaccgctgg atccaggatg agatggagct gggctacgtt caggcgccgc     1140

acaagaccct cccggtggtc tttgactccc caaggaatgg ggaactgcag gatttccctt     1200

acaaaagaat cctggtcaag tggccgcagg gtcacccagg tggtgcggga cttcctccat     1260

gcccagaagg tgcagccccc cgtggagctc tttgtggact ggttggccgt gggccatgtg     1320

gatgagtttc tgagctttgt ccctgccccc gatgggaagg gcttccggat gctcctggcc     1380

agccctgggg cctgcttcaa gctcttccag gaaaagcaga agtgtggcca cgggagggcc     1440

ctcctgttcc ag                                                         1452


<210>  54
<211>  421
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X3 [Homo sapiens]

<400>  54

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr His 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Val Lys Trp Pro Gln Gly His Pro Gly Gly Ala Gly Leu Pro Pro 
385                 390                 395                 400 


Cys Pro Glu Gly Ala Ala Pro Arg Gly Ala Leu Cys Gly Leu Val Gly 
                405                 410                 415     


Arg Gly Pro Cys Gly 
            420     


<210>  55
<211>  1452
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X3, mRNA

<400>  55
cctaaggggc ctcaggggca gtgttggggt tggcggccac agctaagtcc aacaccagca       60

tgtcgctgca gagaatcgtg cgtgtgtccc tggagcatcc caccagcgcg gtgtgtgtgg      120

ctggcgtgga gaccctcgtg gacatttatg ggtcagtgcc tgagggcaca gaaatgtttg      180

aggtctatgg gacgcctggc gtggacatct acatctctcc caacatggag aggggccggg      240

agcgtgcaga caccaggcgg tggcgctttg acgcgacttt ggagatcatc gtggtcatga      300

actcccccag caatgacctc aacgacagcc atgttcagat ttcctaccac tccagccatg      360

agcctctgcc cctggcctat gcggtgctct acctcacctg tgttgacatc tctctggatt      420

gcgacctgaa ctgtgaggga aggcaggaca ggaactttgt agacaagcgg cagtgggtct      480

gggggcccag tgggtatggc ggcatcttgc tggtgaactg tgaccgtgat gatccgagct      540

gtgatgtcca ggacaattgt gaccagcaca tgcactgcct gcaagacctg gaagacatgt      600

ctgtcatggt cctgcggacg cagggccctg cagccctctt tgatgaccac aaacttgtcc      660

tccatacctc cagctatgat gccaaacggg cacaggtctt ccacatctgc ggtcctgagg      720

atgtgtgtga ggcctatagg catgtgctgg gccaagataa ggtgtcctat gaggtacccc      780

gcttgcatgg ggatgaggag cgcttcttcg tggaaggcct gtccttccct gatgccggct      840

tcacaggact catctccttc catgtcactc tgctggacga ctccaacgag gatttctcgg      900

catcccctat cttcactgac actgtggtgt tccgagtggc accctggatc atgacgccca      960

gcactctgcc acccctagag gtgtatgtgt gccgtgtgag gaacaacacg tgttttgtgg     1020

atgcggtggc agagctggcc aggaaggccg gctgcaagct gaccatctgc ccacaggccg     1080

agaaccgcaa cgaccgctgg atccaggatg agatggagct gggctacgtt caggcgccgc     1140

acaagaccct cccggtggtc tttgactccc caaggaatgg ggaactgcag gatttccctt     1200

acaaaagaat cctggtcaag tggccgcagg gtcacccagg tggtgcggga cttcctccat     1260

gcccagaagg tgcagccccc cgtggagctc tttgtggact ggttggccgt gggccatgtg     1320

gatgagtttc tgagctttgt ccctgccccc gatgggaagg gcttccggat gctcctggcc     1380

agccctgggg cctgcttcaa gctcttccag gaaaagcaga agtgtggcca cgggagggcc     1440

ctcctgttcc ag                                                         1452


<210>  56
<211>  421
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X3 [Homo sapiens]

<400>  56

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Met His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Val Lys Trp Pro Gln Gly His Pro Gly Gly Ala Gly Leu Pro Pro 
385                 390                 395                 400 


Cys Pro Glu Gly Ala Ala Pro Arg Gly Ala Leu Cys Gly Leu Val Gly 
                405                 410                 415     


Arg Gly Pro Cys Gly 
            420     


<210>  57
<211>  1452
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X3, mRNA

<400>  57
cctaaggggc ctcaggggca gtgttggggt tggcggccac agctaagtcc aacaccagca       60

tgtcgctgca gagaatcgtg cgtgtgtccc tggagcatcc caccagcgcg gtgtgtgtgg      120

ctggcgtgga gaccctcgtg gacatttatg ggtcagtgcc tgagggcaca gaaatgtttg      180

aggtctatgg gacgcctggc gtggacatct acatctctcc caacatggag aggggccggg      240

agcgtgcaga caccaggcgg tggcgctttg acgcgacttt ggagatcatc gtggtcatga      300

actcccccag caatgacctc aacgacagcc atgttcagat ttcctaccac tccagccatg      360

agcctctgcc cctggcctat gcggtgctct acctcacctg tgttgacatc tctctggatt      420

gcgacctgaa ctgtgaggga aggcaggaca ggaactttgt agacaagcgg cagtgggtct      480

gggggcccag tgggtatggc ggcatcttgc tggtgaactg tgaccgtgat gatccgagct      540

gtgatgtcca ggacaattgt gaccagcacg tgcactgcct gcaagacctg gaagacatgt      600

ctgtcatggt cctgcggacg cagggccctg cagccctctt tgatgaccac aaacttgtcc      660

tccatacctc cagctatgat gccaaacggg cacaggtctt ccacatctgc ggtcctgagg      720

atgtgtgtga ggcctatagg catgtgctgg gccaagataa ggtgtcctat gaggtacccc      780

gcttgcatgg ggatgaggag cgcttcttcg tggaaggcct gtccttccct gatgccggct      840

tcacaggact catctccttc catgtcactc tgctggacga ctccaacgag gatttctcgg      900

catcccctat cttcactgac actgtggtgt tccgagtggt accctggatc atgacgccca      960

gcactctgcc acccctagag gtgtatgtgt gccgtgtgag gaacaacacg tgttttgtgg     1020

atgcggtggc agagctggcc aggaaggccg gctgcaagct gaccatctgc ccacaggccg     1080

agaaccgcaa cgaccgctgg atccaggatg agatggagct gggctacgtt caggcgccgc     1140

acaagaccct cccggtggtc tttgactccc caaggaatgg ggaactgcag gatttccctt     1200

acaaaagaat cctggtcaag tggccgcagg gtcacccagg tggtgcggga cttcctccat     1260

gcccagaagg tgcagccccc cgtggagctc tttgtggact ggttggccgt gggccatgtg     1320

gatgagtttc tgagctttgt ccctgccccc gatgggaagg gcttccggat gctcctggcc     1380

agccctgggg cctgcttcaa gctcttccag gaaaagcaga agtgtggcca cgggagggcc     1440

ctcctgttcc ag                                                         1452


<210>  58
<211>  421
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-3 isoform X3 [Homo sapiens]

<400>  58

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Val Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Val Lys Trp Pro Gln Gly His Pro Gly Gly Ala Gly Leu Pro Pro 
385                 390                 395                 400 


Cys Pro Glu Gly Ala Ala Pro Arg Gly Ala Leu Cys Gly Leu Val Gly 
                405                 410                 415     


Arg Gly Pro Cys Gly 
            420     


<210>  59
<211>  1452
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 3 (PADI3), 
       transcript variant X3, mRNA

<400>  59
cctaaggggc ctcaggggca gtgttggggt tggcggccac agctaagtcc aacaccagca       60

tgtcgctgca gagaatcgtg cgtgtgtccc tggagcatcc caccagcgcg gtgtgtgtgg      120

ctggcgtgga gaccctcgtg gacatttatg ggtcagtgcc tgagggcaca gaaatgtttg      180

aggtctatgg gacgcctggc gtggacatct acatctctcc caacatggag aggggccggg      240

agcgtgcaga caccaggcgg tggcgctttg acgcgacttt ggagatcatc gtggtcatga      300

actcccccag caatgacctc aacgacagcc atgttcagat ttcctaccac tccagccatg      360

agcctctgcc cctggcctat gcggtgctct acctcacctg tgttgacatc tctctggatt      420

gcgacctgaa ctgtgaggga aggcaggaca ggaactttgt agacaagcgg cagtgggtct      480

gggggcccag tgggtatggc ggcatcttgc tggtgaactg tgaccgtgat gatccgagct      540

gtgatgtcca ggacaattgt gaccagcacg tgcactgcct gcaagacctg gaagacatgt      600

ctgtcatggt cctgcggacg cagggccctg cagccctctt tgatgaccac aaacttgtcc      660

tccatacctc cagctatgat gccaaacggg cacaggtctt ccacatctgc ggtcctgagg      720

atgtgtgtga ggcctatagg catgtgctgg gccaagataa ggtgtcctat gaggtacccc      780

gcttgcatgg ggatgaggag cgcttcttcg tggaaggcct gtccttccct gatgccggct      840

tcacaggact catctccttc catgtcactc tgctggacga ctccaacgag gatttctcgg      900

catcccctat cttcactgac actgtggtgt tccgagtggc accctggatc atgacgccca      960

gcactctgcc acccctagag gtgtatgtgt gccgtgtgag gaacaacacg tgttttgtgg     1020

atgcggtggc agagctggcc aggaaggccg gctgcaagct gaccatctgc ccacaggccg     1080

agaaccgcaa cgaccgctgg atccaggatg agatggagct gggctacgtt caggcgccgc     1140

acaagaccct cccggtggtc tttgactccc caaggaatgg ggaactgcag gatttccctt     1200

acaaaagaat cctggtcaag tggccgcagg gtcacccagg tggtgcggga cttcctccat     1260

gcccagaagg tgcagccccc cgtggagctc tttgtggact ggttggccgt gggccatgtg     1320

gatgagtttc tgagctttgt ccctgccccc gatgggaagg gcttccggat gctcctggcc     1380

agccctgggg cctgcttcaa gctcttccag gaaaagcaga agtgtggcca cgggagggcc     1440

ctcctgttcc ag                                                         1452


<210>  60

<400>  60
000

<210>  61
<211>  2267
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 4 (PADI4), mRNA

<400>  61
agccagaggg acgagctagc ccgacgatgg cccaggggac attgatccgt gtgaccccag       60

agcagcccac ccatgccgtg tgtgtgctgg gcaccttgac tcagcttgac atctgcagct      120

ctgcccctga ggactgcacg tccttcagca tcaacgcctc cccaggggtg gtcgtggata      180

ttgcccacgg ccctccagcc aagaagaaat ccacaggttc ctccacatgg cccctggacc      240

ctggggtaga ggtgaccctg acgatgaaag tggccagtgg tagcacaggc gaccagaagg      300

ttcagatttc atactacgga cccaagactc caccagtcaa agctctactc tacctcaccg      360

gggtggaaat ctccttgtgc gcagacatca cccgcaccgg caaagtgaag ccaaccagag      420

ctgtgaaaga tcagaggacc tggacctggg gcccttgtgg acagggtgcc atcctgctgg      480

tgaactgtga cagagacaat ctcgaatctt ctgccatgga ctgcgaggat gatgaagtgc      540

ttgacagcga agacctgcag gacatgtcgc tgatgaccct gagcacgaag acccccaagg      600

acttcttcac aaaccataca ctggtgctcc acgtggccag gtctgagatg gacaaagtga      660

gggtgtttca ggccacacgg ggcaaactgt cctccaagtg cagcgtagtc ttgggtccca      720

agtggccctc tcactacctg atggtccccg gtggaaagca caacatggac ttctacgtgg      780

aggccctcgc tttcccggac accgacttcc cggggctcat taccctcacc atctccctgc      840

tggacacgtc caacctggag ctccccgagg ctgtggtgtt ccaagacagc gtggtcttcc      900

gcgtggcgcc ctggatcatg acccccaaca cccagccccc gcaggaggtg tacgcgtgca      960

gtatttttga aaatgaggac ttcctgaagt cagtgactac tctggccatg aaagccaagt     1020

gcaagctgac catctgccct gaggaggaga acatggatga ccagtggatg caggatgaaa     1080

tggagatcgg ctacatccaa gccccacaca aaacgctgcc cgtggtcttc gactctccaa     1140

ggaacagagg cctgaaggag tttcccatca aacgcgtgat gggtccagat tttggctatg     1200

taactcgagg gccccaaaca gggggtatca gtggactgga ctcctttggg aacctggaag     1260

tgagcccccc agtcacagtc aggggcaagg aatacccgct gggcaggatt ctcttcgggg     1320

acagctgtta tcccagcaat gacagccggc agatgcacca ggccctgcag gacttcctca     1380

gtgcccagca ggtgcaggcc cctgtgaagc tctattctga ctggctgtcc gtgggccacg     1440

tggacgagtt cctgagcttt gtgccagcac ccgacaggaa gggcttccgg ctgctcctgg     1500

ccagccccag gtcctgctac aaactgttcc aggagcagca gaatgagggc cacggggagg     1560

ccctgctgtt cgaagggatc aagaaaaaaa aacagcagaa aataaagaac attctgtcaa     1620

acaagacatt gagagaacat aattcatttg tggagagatg catcgactgg aaccgcgagc     1680

tgctgaagcg ggagctgggc ctggccgaga gtgacatcat tgacatcccg cagctcttca     1740

agctcaaaga gttctctaag gcggaagctt ttttccccaa catggtgaac atgctggtgc     1800

tagggaagca cctgggcatc cccaagccct tcgggcccgt catcaacggc cgctgctgcc     1860

tggaggagaa ggtgtgttcc ctgctggagc cactgggcct ccagtgcacc ttcatcaacg     1920

acttcttcac ctaccacatc aggcatgggg aggtgcactg cggcaccaac gtgcgcagaa     1980

agcccttctc cttcaagtgg tggaacatgg tgccctgagc ccatcttccc tggcgtcctc     2040

tccctcctgg ccagatgtcg ctgggtcctc tgcagtgtgg caagcaagag ctcttgtgaa     2100

tattgtggct ccctgggggc ggccagccct cccagcagtg gcttgctttc ttctcctgtg     2160

atgtcccagt ttcccactct gaagatccca acatggtcct agcactgcac actcagttct     2220

gctctaagaa gctgcaataa agttttttta agtcactttg tacatga                   2267


<210>  62
<211>  663
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 [Homo sapiens]

<400>  62

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr Gly Gly 
385                 390                 395                 400 


Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe Gly Asp 
            420                 425                 430         


Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala Leu Gln 
        435                 440                 445             


Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro 
465                 470                 475                 480 


Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser 
                485                 490                 495     


Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala 
            500                 505                 510         


Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn 
        515                 520                 525             


Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg 
    530                 535                 540                 


Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala 
545                 550                 555                 560 


Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe 
                565                 570                 575     


Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu 
            580                 585                 590         


Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His 
625                 630                 635                 640 


Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  63
<211>  2267
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 4 (PADI4), mRNA

<400>  63
agccagaggg acgagctagc ccgacgatgg cccaggggac attgatccat gtgaccccag       60

agcagcccac ccatgccgtg tgtgtgctgg gcaccttgac tcagcttgac atctgcagct      120

ctgcccctga ggactgcacg tccttcagca tcaacgcctc cccaggggtg gtcgtggata      180

ttgcccacgg ccctccagcc aagaagaaat ccacaggttc ctccacatgg cccctggacc      240

ctggggtaga ggtgaccctg acgatgaaag tggccagtgg tagcacaggc gaccagaagg      300

ttcagatttc atactacgga cccaagactc caccagtcaa agctctactc tacctcaccg      360

gggtggaaat ctccttgtgc gcagacatca cccgcaccgg caaagtgaag ccaaccagag      420

ctgtgaaaga tcagaggacc tggacctggg gcccttgtgg acagggtgcc atcctgctgg      480

tgaactgtga cagagacaat ctcgaatctt ctgccatgga ctgcgaggat gatgaagtgc      540

ttgacagcga agacctgcag gacatgtcgc tgatgaccct gagcacgaag acccccaagg      600

acttcttcac aaaccataca ctggtgctcc acgtggccag gtctgagatg gacaaagtga      660

gggtgtttca ggccacacgg ggcaaactgt cctccaagtg cagcgtagtc ttgggtccca      720

agtggccctc tcactacctg atggtccccg gtggaaagca caacatggac ttctacgtgg      780

aggccctcgc tttcccggac accgacttcc cggggctcat taccctcacc atctccctgc      840

tggacacgtc caacctggag ctccccgagg ctgtggtgtt ccaagacagc gtggtcttcc      900

gcgtggcgcc ctggatcatg acccccaaca cccagccccc gcaggaggtg tacgcgtgca      960

gtatttttga aaatgaggac ttcctgaagt cagtgactac tctggccatg aaagccaagt     1020

gcaagctgac catctgccct gaggaggaga acatggatga ccagtggatg caggatgaaa     1080

tggagatcgg ctacatccaa gccccacaca aaacgctgcc cgtggtcttc gactctccaa     1140

ggaacagagg cctgaaggag tttcccatca aacgcgtgat gggtccagat tttggctatg     1200

taactcgagg gccccaaaca gggggtatca gtggactgga ctcctttggg aacctggaag     1260

tgagcccccc agtcacagtc aggggcaagg aatacccgct gggcaggatt ctcttcgggg     1320

acagctgtta tcccagcaat gacagccggc agatgcacca ggccctgcag gacttcctca     1380

gtgcccagca ggtgcaggcc cctgtgaagc tctattctga ctggctgtcc gtgggccacg     1440

tggacgagtt cctgagcttt gtgccagcac ccgacaggaa gggcttccgg ctgctcctgg     1500

ccagccccag gtcctgctac aaactgttcc aggagcagca gaatgagggc cacggggagg     1560

ccctgctgtt cgaagggatc aagaaaaaaa aacagcagaa aataaagaac attctgtcaa     1620

acaagacatt gagagaacat aattcatttg tggagagatg catcgactgg aaccgcgagc     1680

tgctgaagcg ggagctgggc ctggccgaga gtgacatcat tgacatcccg cagctcttca     1740

agctcaaaga gttctctaag gcggaagctt ttttccccaa catggtgaac atgctggtgc     1800

tagggaagca cctgggcatc cccaagccct tcgggcccgt catcaacggc cgctgctgcc     1860

tggaggagaa ggtgtgttcc ctgctggagc cactgggcct ccagtgcacc ttcatcaacg     1920

acttcttcac ctaccacatc aggcatgggg aggtgcactg cggcaccaac gtgcgcagaa     1980

agcccttctc cttcaagtgg tggaacatgg tgccctgagc ccatcttccc tggcgtcctc     2040

tccctcctgg ccagatgtcg ctgggtcctc tgcagtgtgg caagcaagag ctcttgtgaa     2100

tattgtggct ccctgggggc ggccagccct cccagcagtg gcttgctttc ttctcctgtg     2160

atgtcccagt ttcccactct gaagatccca acatggtcct agcactgcac actcagttct     2220

gctctaagaa gctgcaataa agttttttta agtcactttg tacatga                   2267


<210>  64
<211>  663
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 [Homo sapiens]

<400>  64

Met Ala Gln Gly Thr Leu Ile His Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr Gly Gly 
385                 390                 395                 400 


Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe Gly Asp 
            420                 425                 430         


Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala Leu Gln 
        435                 440                 445             


Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro 
465                 470                 475                 480 


Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser 
                485                 490                 495     


Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala 
            500                 505                 510         


Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn 
        515                 520                 525             


Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg 
    530                 535                 540                 


Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala 
545                 550                 555                 560 


Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe 
                565                 570                 575     


Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu 
            580                 585                 590         


Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His 
625                 630                 635                 640 


Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  65
<211>  2267
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens peptidyl arginine deiminase 4 (PADI4), mRNA

<400>  65
agccagaggg acgagctagc ccgacgatgg cccaggggac attgatcctt gtgaccccag       60

agcagcccac ccatgccgtg tgtgtgctgg gcaccttgac tcagcttgac atctgcagct      120

ctgcccctga ggactgcacg tccttcagca tcaacgcctc cccaggggtg gtcgtggata      180

ttgcccacgg ccctccagcc aagaagaaat ccacaggttc ctccacatgg cccctggacc      240

ctggggtaga ggtgaccctg acgatgaaag tggccagtgg tagcacaggc gaccagaagg      300

ttcagatttc atactacgga cccaagactc caccagtcaa agctctactc tacctcaccg      360

gggtggaaat ctccttgtgc gcagacatca cccgcaccgg caaagtgaag ccaaccagag      420

ctgtgaaaga tcagaggacc tggacctggg gcccttgtgg acagggtgcc atcctgctgg      480

tgaactgtga cagagacaat ctcgaatctt ctgccatgga ctgcgaggat gatgaagtgc      540

ttgacagcga agacctgcag gacatgtcgc tgatgaccct gagcacgaag acccccaagg      600

acttcttcac aaaccataca ctggtgctcc acgtggccag gtctgagatg gacaaagtga      660

gggtgtttca ggccacacgg ggcaaactgt cctccaagtg cagcgtagtc ttgggtccca      720

agtggccctc tcactacctg atggtccccg gtggaaagca caacatggac ttctacgtgg      780

aggccctcgc tttcccggac accgacttcc cggggctcat taccctcacc atctccctgc      840

tggacacgtc caacctggag ctccccgagg ctgtggtgtt ccaagacagc gtggtcttcc      900

gcgtggcgcc ctggatcatg acccccaaca cccagccccc gcaggaggtg tacgcgtgca      960

gtatttttga aaatgaggac ttcctgaagt cagtgactac tctggccatg aaagccaagt     1020

gcaagctgac catctgccct gaggaggaga acatggatga ccagtggatg caggatgaaa     1080

tggagatcgg ctacatccaa gccccacaca aaacgctgcc cgtggtcttc gactctccaa     1140

ggaacagagg cctgaaggag tttcccatca aacgcgtgat gggtccagat tttggctatg     1200

taactcgagg gccccaaaca gggggtatca gtggactgga ctcctttggg aacctggaag     1260

tgagcccccc agtcacagtc aggggcaagg aatacccgct gggcaggatt ctcttcgggg     1320

acagctgtta tcccagcaat gacagccggc agatgcacca ggccctgcag gacttcctca     1380

gtgcccagca ggtgcaggcc cctgtgaagc tctattctga ctggctgtcc gtgggccacg     1440

tggacgagtt cctgagcttt gtgccagcac ccgacaggaa gggcttccgg ctgctcctgg     1500

ccagccccag gtcctgctac aaactgttcc aggagcagca gaatgagggc cacggggagg     1560

ccctgctgtt cgaagggatc aagaaaaaaa aacagcagaa aataaagaac attctgtcaa     1620

acaagacatt gagagaacat aattcatttg tggagagatg catcgactgg aaccgcgagc     1680

tgctgaagcg ggagctgggc ctggccgaga gtgacatcat tgacatcccg cagctcttca     1740

agctcaaaga gttctctaag gcggaagctt ttttccccaa catggtgaac atgctggtgc     1800

tagggaagca cctgggcatc cccaagccct tcgggcccgt catcaacggc cgctgctgcc     1860

tggaggagaa ggtgtgttcc ctgctggagc cactgggcct ccagtgcacc ttcatcaacg     1920

acttcttcac ctaccacatc aggcatgggg aggtgcactg cggcaccaac gtgcgcagaa     1980

agcccttctc cttcaagtgg tggaacatgg tgccctgagc ccatcttccc tggcgtcctc     2040

tccctcctgg ccagatgtcg ctgggtcctc tgcagtgtgg caagcaagag ctcttgtgaa     2100

tattgtggct ccctgggggc ggccagccct cccagcagtg gcttgctttc ttctcctgtg     2160

atgtcccagt ttcccactct gaagatccca acatggtcct agcactgcac actcagttct     2220

gctctaagaa gctgcaataa agttttttta agtcactttg tacatga                   2267


<210>  66
<211>  663
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 [Homo sapiens]

<400>  66

Met Ala Gln Gly Thr Leu Ile Leu Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr Gly Gly 
385                 390                 395                 400 


Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe Gly Asp 
            420                 425                 430         


Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala Leu Gln 
        435                 440                 445             


Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro 
465                 470                 475                 480 


Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser 
                485                 490                 495     


Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala 
            500                 505                 510         


Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn 
        515                 520                 525             


Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg 
    530                 535                 540                 


Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala 
545                 550                 555                 560 


Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe 
                565                 570                 575     


Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu 
            580                 585                 590         


Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His 
625                 630                 635                 640 


Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  67
<211>  1801
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X3, mRNA

<400>  67
tctacctcac cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga       60

agccaaccag agctgtgaaa gatcagacct gcaggacatg tcgctgatga ccctgagcac      120

gaagaccccc aaggacttct tcacaaacca tacactggtg ctccacgtgg ccaggtctga      180

gatggacaaa gtgagggtgt ttcaggccac acggggcaaa ctgtcctcca agtgcagcgt      240

agtcttgggt cccaagtggc cctctcacta cctgatggtc cccggtggaa agcacaacat      300

ggacttctac gtggaggccc tcgctttccc ggacaccgac ttcccggggc tcattaccct      360

caccatctcc ctgctggaca cgtccaacct ggagctcccc gaggctgtgg tgttccaaga      420

cagcgtggtc ttccgcgtgg cgccctggat catgaccccc aacacccagc ccccgcagga      480

ggtgtacgcg tgcagtattt ttgaaaatga ggacttcctg aagtcagtga ctactctggc      540

catgaaagcc aagtgcaagc tgaccatctg ccctgaggag gagaacatgg atgaccagtg      600

gatgcaggat gaaatggaga tcggctacat ccaagcccca cacaaaacgc tgcccgtggt      660

cttcgactct ccaaggaaca gaggcctgaa ggagtttccc atcaaacgcg tgatgggtcc      720

agattttggc tatgtaactc gagggcccca aacagggggt atcagtggac tggactcctt      780

tgggaacctg gaagtgagcc ccccagtcac agtcaggggc aaggaatacc cgctgggcag      840

gattctcttc ggggacagct gttatcccag caatgacagc cggcagatgc accaggccct      900

gcaggacttc ctcagtgccc agcaggtgca ggcccctgtg aagctctatt ctgactggct      960

gtccgtgggc cacgtggacg agttcctgag ctttgtgcca gcacccgaca ggaagggctt     1020

ccggctgctc ctggccagcc ccaggtcctg ctacaaactg ttccaggagc agcagaatga     1080

gggccacggg gaggccctgc tgttcgaagg gatcaagaaa aaaaaacagc agaaaataaa     1140

gaacattctg tcaaacaaga cattgagaga acataattca tttgtggaga gatgcatcga     1200

ctggaaccgc gagctgctga agcgggagct gggcctggcc gagagtgaca tcattgacat     1260

cccgcagctc ttcaagctca aagagttctc taaggcggaa gcttttttcc ccaacatggt     1320

gaacatgctg gtgctaggga agcacctggg catccccaag cccttcgggc ccgtcatcaa     1380

cggccgctgc tgcctggagg agaaggtgtg ttccctgctg gagccactgg gcctccagtg     1440

caccttcatc aacgacttct tcacctacca catcaggcat ggggaggtgc actgcggcac     1500

caacgtgcgc agaaagccct tctccttcaa gtggtggaac atggtgccct gagcccatct     1560

tccctggcgt cctctccctc ctggccagat gtcgctgggt cctctgcagt gtggcaagca     1620

agagctcttg tgaatattgt ggctccctgg gggcggccag ccctcccagc agtggcttgc     1680

tttcttctcc tgtgatgtcc cagtttccca ctctgaagat cccaacatgg tcctagcact     1740

gcacactcag ttctgctcta agaagctgca ataaagtttt tttaagtcac tttgtacatg     1800

a                                                                     1801


<210>  68
<211>  1748
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X8, mRNA

<400>  68
agctctactc tacctcaccg gggtggaaat ctccttgtgc gcagacatca cccgcaccgg       60

caaagtgaag ccaaccagag ctgtgaaaga tcagaggacc tggacctggg gcccttgtgg      120

acagggtgcc atcctgctgg tgaactgtga cagagacaat ctcgaatctt ctgccatgga      180

ctgcgaggat gatgaagtgc ttgacagcga agacctgcag gacatgtcgc tgatgaccct      240

gagcacgaag acccccaagg acttcttcac aaaccataca ctggtgctcc acgtggccag      300

gtctgagatg gacaaagtga gggtgtttca ggccacacga gctccccgag gctgtggtgt      360

tccaagacag cgtggtcttc cgcgtggcgc cctggatcat gacccccaac acccagcccc      420

cgcaggaggt gtacgcgtgc agtatttttg aaaatgagga cttcctgaag tcagtgacta      480

ctctggccat gaaagccaag tgcaagctga ccatctgccc tgaggaggag aacatggatg      540

accagtggat gcaggatgaa atggagatcg gctacatcca agccccacac aaaacgctgc      600

ccgtggtctt cgactctcca aggaacagag gcctgaagga gtttcccatc aaacgcgtga      660

tgggtccaga ttttggctat gtaactcgag ggccccaaac agggggtatc agtggactgg      720

actcctttgg gaacctggaa gtgagccccc cagtcacagt caggggcaag gaatacccgc      780

tgggcaggat tctcttcggg gacagctgtt atcccagcaa tgacagccgg cagatgcacc      840

aggccctgca ggacttcctc agtgcccagc aggtgcaggc ccctgtgaag ctctattctg      900

actggctgtc cgtgggccac gtggacgagt tcctgagctt tgtgccagca cccgacagga      960

agggcttccg gctgctcctg gccagcccca ggtcctgcta caaactgttc caggagcagc     1020

agaatgaggg ccacggggag gccctgctgt tcgaagggat caagaaaaaa aaacagcaga     1080

aaataaagaa cattctgtca aacaagacat tgagagaaca taattcattt gtggagagat     1140

gcatcgactg gaaccgcgag ctgctgaagc gggagctggg cctggccgag agtgacatca     1200

ttgacatccc gcagctcttc aagctcaaag agttctctaa ggcggaagct tttttcccca     1260

acatggtgaa catgctggtg ctagggaagc acctgggcat ccccaagccc ttcgggcccg     1320

tcatcaacgg ccgctgctgc ctggaggaga aggtgtgttc cctgctggag ccactgggcc     1380

tccagtgcac cttcatcaac gacttcttca cctaccacat caggcatggg gaggtgcact     1440

gcggcaccaa cgtgcgcaga aagcccttct ccttcaagtg gtggaacatg gtgccctgag     1500

cccatcttcc ctggcgtcct ctccctcctg gccagatgtc gctgggtcct ctgcagtgtg     1560

gcaagcaaga gctcttgtga atattgtggc tccctggggg cggccagccc tcccagcagt     1620

ggcttgcttt cttctcctgt gatgtcccag tttcccactc tgaagatccc aacatggtcc     1680

tagcactgca cactcagttc tgctctaaga agctgcaata aagttttttt aagtcacttt     1740

gtacatga                                                              1748


<210>  69
<211>  2081
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X1, mRNA

<400>  69
agccagaggg acgagctagc ccgacgatgg cccaggggac attgatccgt gtgaccccag       60

agcagcccac ccatgccgtg tgtgtgctgg gcaccttgac tcagcttgac atctgcagct      120

ctgcccctga ggactgcacg tccttcagca tcaacgcctc cccaggggtg gtcgtggata      180

ttgcccacgg ccctccagcc aagaagaaat ccacaggttc ctccacatgg cccctggacc      240

ctggggtaga ggtgaccctg acgatgaaag tggccagtgg tagcacaggc gaccagaagg      300

ttcagatttc atactacgga cccaagactc caccagtcaa agctctactc tacctcaccg      360

gggtggacct gcaggacatg tcgctgatga ccctgagcac gaagaccccc aaggacttct      420

tcacaaacca tacactggtg ctccacgtgg ccaggtctga gatggacaaa gtgagggtgt      480

ttcaggccac acggggcaaa ctgtcctcca agtgcagcgt agtcttgggt cccaagtggc      540

cctctcacta cctgatggtc cccggtggaa agcacaacat ggacttctac gtggaggccc      600

tcgctttccc ggacaccgac ttcccggggc tcattaccct caccatctcc ctgctggaca      660

cgtccaacct ggagctcccc gaggctgtgg tgttccaaga cagcgtggtc ttccgcgtgg      720

cgccctggat catgaccccc aacacccagc ccccgcagga ggtgtacgcg tgcagtattt      780

ttgaaaatga ggacttcctg aagtcagtga ctactctggc catgaaagcc aagtgcaagc      840

tgaccatctg ccctgaggag gagaacatgg atgaccagtg gatgcaggat gaaatggaga      900

tcggctacat ccaagcccca cacaaaacgc tgcccgtggt cttcgactct ccaaggaaca      960

gaggcctgaa ggagtttccc atcaaacgcg tgatgggtcc agattttggc tatgtaactc     1020

gagggcccca aacagggggt atcagtggac tggactcctt tgggaacctg gaagtgagcc     1080

ccccagtcac agtcaggggc aaggaatacc cgctgggcag gattctcttc ggggacagct     1140

gttatcccag caatgacagc cggcagatgc accaggccct gcaggacttc ctcagtgccc     1200

agcaggtgca ggcccctgtg aagctctatt ctgactggct gtccgtgggc cacgtggacg     1260

agttcctgag ctttgtgcca gcacccgaca ggaagggctt ccggctgctc ctggccagcc     1320

ccaggtcctg ctacaaactg ttccaggagc agcagaatga gggccacggg gaggccctgc     1380

tgttcgaagg gatcaagaaa aaaaaacagc agaaaataaa gaacattctg tcaaacaaga     1440

cattgagaga acataattca tttgtggaga gatgcatcga ctggaaccgc gagctgctga     1500

agcgggagct gggcctggcc gagagtgaca tcattgacat cccgcagctc ttcaagctca     1560

aagagttctc taaggcggaa gcttttttcc ccaacatggt gaacatgctg gtgctaggga     1620

agcacctggg catccccaag cccttcgggc ccgtcatcaa cggccgctgc tgcctggagg     1680

agaaggtgtg ttccctgctg gagccactgg gcctccagtg caccttcatc aacgacttct     1740

tcacctacca catcaggcat ggggaggtgc actgcggcac caacgtgcgc agaaagccct     1800

tctccttcaa gtggtggaac atggtgccct gagcccatct tccctggcgt cctctccctc     1860

ctggccagat gtcgctgggt cctctgcagt gtggcaagca agagctcttg tgaatattgt     1920

ggctccctgg gggcggccag ccctcccagc agtggcttgc tttcttctcc tgtgatgtcc     1980

cagtttccca ctctgaagat cccaacatgg tcctagcact gcacactcag ttctgctcta     2040

agaagctgca ataaagtttt tttaagtcac tttgtacatg a                         2081


<210>  70
<211>  601
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X1 [Homo sapiens]

<400>  70

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Asp Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro 
        115                 120                 125             


Lys Asp Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser 
    130                 135                 140                 


Glu Met Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser 
145                 150                 155                 160 


Ser Lys Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu 
                165                 170                 175     


Met Val Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu 
            180                 185                 190         


Ala Phe Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser 
        195                 200                 205             


Leu Leu Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln 
    210                 215                 220                 


Asp Ser Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr 
225                 230                 235                 240 


Gln Pro Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp 
                245                 250                 255     


Phe Leu Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu 
            260                 265                 270         


Thr Ile Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp 
        275                 280                 285             


Glu Met Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val 
    290                 295                 300                 


Val Phe Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys 
305                 310                 315                 320 


Arg Val Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr 
                325                 330                 335     


Gly Gly Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro 
            340                 345                 350         


Pro Val Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe 
        355                 360                 365             


Gly Asp Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala 
    370                 375                 380                 


Leu Gln Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu 
385                 390                 395                 400 


Tyr Ser Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe 
                405                 410                 415     


Val Pro Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro 
            420                 425                 430         


Arg Ser Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly 
        435                 440                 445             


Glu Ala Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile 
    450                 455                 460                 


Lys Asn Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val 
465                 470                 475                 480 


Glu Arg Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly 
                485                 490                 495     


Leu Ala Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys 
            500                 505                 510         


Glu Phe Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu 
        515                 520                 525             


Val Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile 
    530                 535                 540                 


Asn Gly Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro 
545                 550                 555                 560 


Leu Gly Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile 
                565                 570                 575     


Arg His Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
            580                 585                 590         


Ser Phe Lys Trp Trp Asn Met Val Pro 
        595                 600     


<210>  71
<211>  2081
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X1, mRNA

<400>  71
agccagaggg acgagctagc ccgacgatgg cccaggggac attgatccgt gtgaccccag       60

agcagcccac ccatgccgtg tgtgtgctgg gcaccttgac tcagcttgac atctgcagct      120

ctgcccctga ggactgcacg tccttcagca tcaacgcctc cccaggggtg gtcgtggata      180

ttgcccacgg ccctccagcc aagaagaaat ccacaggttc ctccacatgg cccctggacc      240

ctggggtaga ggtgaccctg acgatgaaag tggccagtgg tagcacaggc gaccagaagg      300

ttcagatttc atactacgga cccaagactc caccagtcaa agctctactc tacctcaccg      360

gggtggacct gcaggacatg tcgctgatga ccctgagcac gaagaccccc aaggacttct      420

tcacaaacca tacactggtg ctccacgtgg ccaggtctga gatggacaaa gtgagggtgt      480

ttcaggccac acggggcaaa ctgtcctcca agtgcagcgt agtcttgggt cccaagtggc      540

cctctcacta cctgatggtc cccggtggaa agcacaacat ggacttctac gtggaggccc      600

tcgctttccc ggacaccgac ttcccggggc tcattaccct caccatctcc ctgctggaca      660

cgtccaacct ggagctcccc gaggctgtgg tgttccaaga cagcgtggtc ttccgcgtgg      720

cgccctggat catgaccccc aacacccagc ccccgcagga ggtgtacgcg tgcagtattt      780

ttgaaaatga ggacttcctg aagtcagtga ctactctggc catgaaagcc aagtgcaagc      840

tgaccatctg ccctgaggag gagaacatgg atgaccagtg gatgcaggat gaaatggaga      900

tcggctacat ccaagcccca cacaaaacgc tgcccgtggt cttcgactct ccaaggaaca      960

gaggcctgaa ggagtttccc atcaaacgcg tgatgggtcc agattttggc tatgtaactc     1020

gagggcccca aacagggggt atcagtggac tggactcctt tgggaacctg gaagtgagcc     1080

ccccagtcac agtcaggggc aaggaatacc cgctgggcag gattctcttc ggggacagct     1140

gttatcccag caatgacagc cggcagatgc accaggccct gcaggacttc ctcagtgccc     1200

agcaggtgca ggcccctgtg aagctctatt ctgactggct gtccgtgggc cacgtggacg     1260

agttcctgag ctttgtgcca gcacccgaca ggaagggctt ccggctgctc ctggccagcc     1320

ccaggtcctg ctacaaactg ttccaggagc agcagaatga gggccacggg gaggccctgc     1380

tgttcgaagg gatcaagaaa aaaaaacagc agaaaataaa gaacattctg tcaaacaaga     1440

cattgagaga acataattca tttgtggaga gatgcatcga ctggaaccgc gagctgctga     1500

agcgggagct gggcctggcc gagagtgaca tcattgacat cccgcagctc ttcaagctca     1560

aagagttctc taaggcggaa gcttttttcc ccaacatggt gaacatgctg gtgctaggga     1620

agcacctggg catccccaag cccttcgggc ccgtcatcaa cggccgctgc tgcctggagg     1680

agaaggtgtg ttccctgctg gagccactgg gcctccagtg caccttcatc aacgacttct     1740

tcacctacca catcaggcat ggggaggtgc actgcggcac caacgtgcgc agaaagccct     1800

tctccttcaa gtggtggaac atggtgccct gagcccatct tccctggcgt cctctccctc     1860

ctggccagat gtcgctgggt cctctgcagt gtggcaagca agagctcttg tgaatattgt     1920

ggctccctgg gggcggccag ccctcccagc agtggcttgc tttcttctcc tgtgatgtcc     1980

cagtttccca ctctgaagat cccaacatgg tcctagcact gcacactcag ttctgctcta     2040

agaagctgca ataaagtttt tttaagtcac tttgtacatg a                         2081


<210>  72
<211>  601
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X1 [Homo sapiens]

<400>  72

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Asp Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro 
        115                 120                 125             


Lys Asp Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser 
    130                 135                 140                 


Glu Met Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser 
145                 150                 155                 160 


Ser Lys Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu 
                165                 170                 175     


Met Val Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu 
            180                 185                 190         


Ala Phe Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser 
        195                 200                 205             


Leu Leu Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln 
    210                 215                 220                 


Asp Ser Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr 
225                 230                 235                 240 


Gln Pro Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp 
                245                 250                 255     


Phe Leu Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu 
            260                 265                 270         


Thr Ile Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp 
        275                 280                 285             


Glu Met Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val 
    290                 295                 300                 


Val Phe Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys 
305                 310                 315                 320 


Arg Val Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr 
                325                 330                 335     


Gly Gly Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro 
            340                 345                 350         


Pro Val Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe 
        355                 360                 365             


Gly Asp Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala 
    370                 375                 380                 


Leu Gln Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu 
385                 390                 395                 400 


Tyr Ser Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe 
                405                 410                 415     


Val Pro Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro 
            420                 425                 430         


Arg Ser Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly 
        435                 440                 445             


Glu Ala Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile 
    450                 455                 460                 


Lys Asn Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val 
465                 470                 475                 480 


Glu Arg Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly 
                485                 490                 495     


Leu Ala Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys 
            500                 505                 510         


Glu Phe Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu 
        515                 520                 525             


Val Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile 
    530                 535                 540                 


Asn Gly Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro 
545                 550                 555                 560 


Leu Gly Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile 
                565                 570                 575     


Arg His Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
            580                 585                 590         


Ser Phe Lys Trp Trp Asn Met Val Pro 
        595                 600     


<210>  73
<211>  1969
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X2, mRNA

<400>  73
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atgggcttcc ggctgctcct     1200

ggccagcccc aggtcctgct acaaactgtt ccaggagcag cagaatgagg gccacgggga     1260

ggccctgctg ttcgaaggga tcaagaaaaa aaaacagcag aaaataaaga acattctgtc     1320

aaacaagaca ttgagagaac ataattcatt tgtggagaga tgcatcgact ggaaccgcga     1380

gctgctgaag cgggagctgg gcctggccga gagtgacatc attgacatcc cgcagctctt     1440

caagctcaaa gagttctcta aggcggaagc ttttttcccc aacatggtga acatgctggt     1500

gctagggaag cacctgggca tccccaagcc cttcgggccc gtcatcaacg gccgctgctg     1560

cctggaggag aaggtgtgtt ccctgctgga gccactgggc ctccagtgca ccttcatcaa     1620

cgacttcttc acctaccaca tcaggcatgg ggaggtgcac tgcggcacca acgtgcgcag     1680

aaagcccttc tccttcaagt ggtggaacat ggtgccctga gcccatcttc cctggcgtcc     1740

tctccctcct ggccagatgt cgctgggtcc tctgcagtgt ggcaagcaag agctcttgtg     1800

aatattgtgg ctccctgggg gcggccagcc ctcccagcag tggcttgctt tcttctcctg     1860

tgatgtccca gtttcccact ctgaagatcc caacatggtc ctagcactgc acactcagtt     1920

ctgctctaag aagctgcaat aaagtttttt taagtcactt tgtacatga                 1969


<210>  74
<211>  563
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X2 [Homo sapiens]

<400>  74

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser Cys Tyr Lys Leu 
385                 390                 395                 400 


Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala Leu Leu Phe Glu 
                405                 410                 415     


Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn Ile Leu Ser Asn 
            420                 425                 430         


Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg Cys Ile Asp Trp 
        435                 440                 445             


Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala Glu Ser Asp Ile 
    450                 455                 460                 


Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe Ser Lys Ala Glu 
465                 470                 475                 480 


Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu Gly Lys His Leu 
                485                 490                 495     


Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly Arg Cys Cys Leu 
            500                 505                 510         


Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly Leu Gln Cys Thr 
        515                 520                 525             


Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His Gly Glu Val His 
    530                 535                 540                 


Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe Lys Trp Trp Asn 
545                 550                 555                 560 


Met Val Pro 
            


<210>  75
<211>  1969
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X2, mRNA

<400>  75
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atgggcttcc ggctgctcct     1200

ggccagcccc aggtcctgct acaaactgtt ccaggagcag cagaatgagg gccacgggga     1260

ggccctgctg ttcgaaggga tcaagaaaaa aaaacagcag aaaataaaga acattctgtc     1320

aaacaagaca ttgagagaac ataattcatt tgtggagaga tgcatcgact ggaaccgcga     1380

gctgctgaag cgggagctgg gcctggccga gagtgacatc attgacatcc cgcagctctt     1440

caagctcaaa gagttctcta aggcggaagc ttttttcccc aacatggtga acatgctggt     1500

gctagggaag cacctgggca tccccaagcc cttcgggccc gtcatcaacg gccgctgctg     1560

cctggaggag aaggtgtgtt ccctgctgga gccactgggc ctccagtgca ccttcatcaa     1620

cgacttcttc acctaccaca tcaggcatgg ggaggtgcac tgcggcacca acgtgcgcag     1680

aaagcccttc tccttcaagt ggtggaacat ggtgccctga gcccatcttc cctggcgtcc     1740

tctccctcct ggccagatgt cgctgggtcc tctgcagtgt ggcaagcaag agctcttgtg     1800

aatattgtgg ctccctgggg gcggccagcc ctcccagcag tggcttgctt tcttctcctg     1860

tgatgtccca gtttcccact ctgaagatcc caacatggtc ctagcactgc acactcagtt     1920

ctgctctaag aagctgcaat aaagtttttt taagtcactt tgtacatga                 1969


<210>  76
<211>  563
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X2 [Homo sapiens]

<400>  76

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser Cys Tyr Lys Leu 
385                 390                 395                 400 


Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala Leu Leu Phe Glu 
                405                 410                 415     


Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn Ile Leu Ser Asn 
            420                 425                 430         


Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg Cys Ile Asp Trp 
        435                 440                 445             


Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala Glu Ser Asp Ile 
    450                 455                 460                 


Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe Ser Lys Ala Glu 
465                 470                 475                 480 


Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu Gly Lys His Leu 
                485                 490                 495     


Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly Arg Cys Cys Leu 
            500                 505                 510         


Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly Leu Gln Cys Thr 
        515                 520                 525             


Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His Gly Glu Val His 
    530                 535                 540                 


Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe Lys Trp Trp Asn 
545                 550                 555                 560 


Met Val Pro 
            


<210>  77
<211>  1358
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X4, mRNA

<400>  77
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atgattctat caataggccc     1200

attttataga agaagaaact gaggctcaga gtggagaagt tggaattcaa acccggccag     1260

tccggcttgg gtccagattt tggctatgta actcgagggc cccaaacagg gggtatcagt     1320

ggactggact cctttgggaa cctggaagtg agcccccc                             1358


<210>  78
<211>  397
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X4 [Homo sapiens]

<400>  78

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Ile Leu Ser Ile Gly Pro Phe Tyr Arg Arg Arg Asn 
385                 390                 395         


<210>  79
<211>  1358
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X4, mRNA

<400>  79
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atgattctat caataggccc     1200

attttataga agaagaaact gaggctcaga gtggagaagt tggaattcaa acccggccag     1260

tccggcttgg gtccagattt tggctatgta actcgagggc cccaaacagg gggtatcagt     1320

ggactggact cctttgggaa cctggaagtg agcccccc                             1358


<210>  80
<211>  397
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X4 [Homo sapiens]

<400>  80

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Ile Leu Ser Ile Gly Pro Phe Tyr Arg Arg Arg Asn 
385                 390                 395         


<210>  81
<211>  1842
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X6, mRNA

<400>  81
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atggaagacc ccaggcctgc     1200

gctctgagtc ctggcagccc cttggctcaa ggtgcccagg gaaaacgacg gaaggagtgt     1260

ggggtccaag gtttgctagg acaaatggct ttccgacaag catctgtact gtgccccaag     1320

ggaggggaga gtggccctgc ccacacagaa ggcttcagaa tgaaacttca gttaaactca     1380

acaacttgtc ccgagtctcg cttcctcctg gccaagctgt gcgctgagca gtggagatgc     1440

agagatgctg ttggattcac agtgtgtact cagccatggg gtcgagttca tcctgtttca     1500

gcagcgttgg ggcgaaccag ccagctgcta ccgtgacttt gccctctttc tgctgctttc     1560

agtcctgcct ggttcagtgg ctgtgtctac tttgatgctc caagtataac aaaggccaga     1620

ttttctgatg ccacaagtcc tgctggacag acagacggac acctcggcac cattgttgtc     1680

ccctttccca cagacaactt tggatgaagg caggcagcac tggtccctca gctaagcaca     1740

tctgtgtatt ccaactcaaa tcactcagaa tgaggccagg tgtggtggct gacacctgta     1800

atcccagcag tttgggaggc caaggaggat ggatcacctg ag                        1842


<210>  82
<211>  392
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X5 [Homo sapiens]

<400>  82

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Glu Asp Pro Arg Pro Ala Leu 
385                 390         


<210>  83
<211>  1842
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X6, mRNA

<400>  83
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atggaagacc ccaggcctgc     1200

gctctgagtc ctggcagccc cttggctcaa ggtgcccagg gaaaacgacg gaaggagtgt     1260

ggggtccaag gtttgctagg acaaatggct ttccgacaag catctgtact gtgccccaag     1320

ggaggggaga gtggccctgc ccacacagaa ggcttcagaa tgaaacttca gttaaactca     1380

acaacttgtc ccgagtctcg cttcctcctg gccaagctgt gcgctgagca gtggagatgc     1440

agagatgctg ttggattcac agtgtgtact cagccatggg gtcgagttca tcctgtttca     1500

gcagcgttgg ggcgaaccag ccagctgcta ccgtgacttt gccctctttc tgctgctttc     1560

agtcctgcct ggttcagtgg ctgtgtctac tttgatgctc caagtataac aaaggccaga     1620

ttttctgatg ccacaagtcc tgctggacag acagacggac acctcggcac cattgttgtc     1680

ccctttccca cagacaactt tggatgaagg caggcagcac tggtccctca gctaagcaca     1740

tctgtgtatt ccaactcaaa tcactcagaa tgaggccagg tgtggtggct gacacctgta     1800

atcccagcag tttgggaggc caaggaggat ggatcacctg ag                        1842


<210>  84
<211>  392
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X5 [Homo sapiens]

<400>  84

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Glu Asp Pro Arg Pro Ala Leu 
385                 390         


<210>  85
<211>  1275
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X7, mRNA

<400>  85
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atgcaatgac agccggcaga     1200

tgcaccaggc cctgcaggac ttcctcagtg cccagcaggt gcaggcccct gtgaagctct     1260

attctgactg gctgt                                                      1275


<210>  86
<211>  386
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X6 [Homo sapiens]

<400>  86

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gln 
385     


<210>  87
<211>  1275
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X7, mRNA

<400>  87
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atgcaatgac agccggcaga     1200

tgcaccaggc cctgcaggac ttcctcagtg cccagcaggt gcaggcccct gtgaagctct     1260

attctgactg gctgt                                                      1275


<210>  88
<211>  386
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X6 [Homo sapiens]

<400>  88

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gln 
385     


<210>  89
<211>  1340
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X5, mRNA

<400>  89
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atgattctat caataggccc     1200

attttataga agaagaaact gaggctcaga gtggagaagt tggaattcaa acccggccag     1260

tccggcttgc aatgacagcc ggcagatgca ccaggccctg caggacttcc tcagtgccca     1320

gcaggtgcag gcccctgtga                                                 1340


<210>  90
<211>  397
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X4 [Homo sapiens]

<400>  90

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Ile Leu Ser Ile Gly Pro Phe Tyr Arg Arg Arg Asn 
385                 390                 395         


<210>  91
<211>  1340
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), 
       transcript variant X5, mRNA

<400>  91
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atgattctat caataggccc     1200

attttataga agaagaaact gaggctcaga gtggagaagt tggaattcaa acccggccag     1260

tccggcttgc aatgacagcc ggcagatgca ccaggccctg caggacttcc tcagtgccca     1320

gcaggtgcag gcccctgtga                                                 1340


<210>  92
<211>  397
<212>  PRT
<213>  Homo sapiens

<220>
<223>  protein-arginine deiminase type-4 isoform X4 [Homo sapiens]

<400>  92

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Ile Leu Ser Ile Gly Pro Phe Tyr Arg Arg Arg Asn 
385                 390                 395         


