                         SEQUENCE LISTING

<110>  Exhaura, Ltd.
       Chalberg, Thomas W.
 
<120>  DUAL LEUCINE ZIPPER KINASE INHIBITORS FOR GENE THERAPY

<130>  EXHA-002/01WO 333159-2007

<140>  PCT/US2020/018161
<141>  2020-02-13

<150>  US 62/806,213
<151>  2019-02-15

<150>  US 62/806,201
<151>  2019-02-15

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Cys Leu His Glu Thr Arg Thr Pro Ser Pro Ser Phe Gly Gly 
1               5                   10                  15      


Phe Val Ser Thr Leu Ser Glu Ala Ser Met Arg Lys Leu Asp Pro Asp 
            20                  25                  30          


Thr Ser Asp Cys Thr Pro Glu Lys Asp Leu Thr Pro Thr His Val Leu 
        35                  40                  45              


Gln Leu His Glu Gln Asp Ala Gly Gly Pro Gly Gly Ala Ala Gly Ser 
    50                  55                  60                  


Pro Glu Ser Arg Ala Ser Arg Val Arg Ala Asp Glu Val Arg Leu Gln 
65                  70                  75                  80  


Cys Gln Ser Gly Ser Gly Phe Leu Glu Gly Leu Phe Gly Cys Leu Arg 
                85                  90                  95      


Pro Val Trp Thr Met Ile Gly Lys Ala Tyr Ser Thr Glu His Lys Gln 
            100                 105                 110         


Gln Gln Glu Asp Leu Trp Glu Val Pro Phe Glu Glu Ile Leu Asp Leu 
        115                 120                 125             


Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe Leu Gly Arg Phe 
    130                 135                 140                 


His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp Leu Lys Glu Thr 
145                 150                 155                 160 


Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn Ile Ile Thr Phe 
                165                 170                 175     


Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile Leu Met Glu Phe 
            180                 185                 190         


Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala Gly Arg Pro Val 
        195                 200                 205             


Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile Ala Gly Gly Met 
    210                 215                 220                 


Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp Leu Lys Ser Pro 
225                 230                 235                 240 


Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile Ser Asp Phe Gly 
                245                 250                 255     


Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met Ser Phe Ala Gly 
            260                 265                 270         


Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn Glu Pro Val Ser 
        275                 280                 285             


Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Leu Leu 
    290                 295                 300                 


Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser Ala Ile Ile Trp 
305                 310                 315                 320 


Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro Ser Ser Cys Pro 
                325                 330                 335     


Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn Ser Lys Pro Arg 
            340                 345                 350         


Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu Asp Ile Ala Ser 
        355                 360                 365             


Ala Asp Val Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln Ala 
    370                 375                 380                 


Glu Trp Arg Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser Glu 
385                 390                 395                 400 


Gly Thr Cys Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg Arg 
                405                 410                 415     


Glu Glu Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg Lys 
            420                 425                 430         


Leu Glu Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met Leu 
        435                 440                 445             


Gln Leu Glu Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala Leu 
    450                 455                 460                 


Glu Arg Arg Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly Leu 
465                 470                 475                 480 


Leu His Gly Asn Thr Met Glu Lys Leu Ile Lys Lys Arg Asn Val Pro 
                485                 490                 495     


Gln Lys Leu Ser Pro His Ser Lys Arg Pro Asp Ile Leu Lys Thr Glu 
            500                 505                 510         


Ser Leu Leu Pro Lys Leu Asp Ala Ala Leu Ser Gly Val Gly Leu Pro 
        515                 520                 525             


Gly Cys Pro Lys Gly Pro Pro Ser Pro Gly Arg Ser Arg Arg Gly Lys 
    530                 535                 540                 


Thr Arg His Arg Lys Ala Ser Ala Lys Gly Ser Cys Gly Asp Leu Pro 
545                 550                 555                 560 


Gly Leu Arg Thr Ala Val Pro Pro His Glu Pro Gly Gly Pro Gly Ser 
                565                 570                 575     


Pro Gly Gly Leu Gly Gly Gly Pro Ser Ala Trp Glu Ala Cys Pro Pro 
            580                 585                 590         


Ala Leu Arg Gly Leu His His Asp Leu Leu Leu Arg Lys Met Ser Ser 
        595                 600                 605             


Ser Ser Pro Asp Leu Leu Ser Ala Ala Leu Gly Ser Arg Gly Arg Gly 
    610                 615                 620                 


Ala Thr Gly Gly Ala Gly Asp Pro Gly Ser Pro Pro Pro Ala Arg Gly 
625                 630                 635                 640 


Asp Thr Pro Pro Ser Glu Gly Ser Ala Pro Gly Ser Thr Ser Pro Asp 
                645                 650                 655     


Ser Pro Gly Gly Ala Lys Gly Glu Pro Pro Pro Pro Val Gly Pro Gly 
            660                 665                 670         


Glu Gly Val Gly Leu Leu Gly Thr Gly Arg Glu Gly Thr Ser Gly Arg 
        675                 680                 685             


Gly Gly Ser Arg Ala Gly Ser Gln His Leu Thr Pro Ala Ala Leu Leu 
    690                 695                 700                 


Tyr Arg Ala Ala Val Thr Arg Ser Gln Lys Arg Gly Ile Ser Ser Glu 
705                 710                 715                 720 


Glu Glu Glu Gly Glu Val Asp Ser Glu Val Glu Leu Thr Ser Ser Gln 
                725                 730                 735     


Arg Trp Pro Gln Ser Leu Asn Met Arg Gln Ser Leu Ser Thr Phe Ser 
            740                 745                 750         


Ser Glu Asn Pro Ser Asp Gly Glu Glu Gly Thr Ala Ser Glu Pro Ser 
        755                 760                 765             


Pro Ser Gly Thr Pro Glu Val Gly Ser Thr Asn Thr Asp Glu Arg Pro 
    770                 775                 780                 


Asp Glu Arg Ser Asp Asp Met Cys Ser Gln Gly Ser Glu Ile Pro Leu 
785                 790                 795                 800 


Asp Pro Pro Pro Ser Glu Val Ile Pro Gly Pro Glu Pro Ser Ser Leu 
                805                 810                 815     


Pro Ile Pro His Gln Glu Leu Leu Arg Glu Arg Gly Pro Pro Asn Ser 
            820                 825                 830         


Glu Asp Ser Asp Cys Asp Ser Thr Glu Leu Asp Asn Ser Asn Ser Val 
        835                 840                 845             


Asp Ala Leu Arg Pro Pro Ala Ser Leu Pro Pro 
    850                 855                 


<210>  2
<211>  892
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Cys Leu His Glu Thr Arg Thr Pro Ser Pro Ser Phe Gly Gly 
1               5                   10                  15      


Phe Val Ser Thr Leu Ser Glu Ala Ser Met Arg Lys Leu Asp Pro Asp 
            20                  25                  30          


Thr Ser Asp Cys Thr Pro Glu Lys Asp Leu Thr Pro Thr Gln Cys Val 
        35                  40                  45              


Leu Arg Asp Val Val Pro Leu Gly Gly Gln Gly Gly Gly Gly Pro Ser 
    50                  55                  60                  


Pro Ser Pro Gly Gly Glu Pro Pro Pro Glu Pro Phe Ala Asn Ser Val 
65                  70                  75                  80  


Leu Gln Leu His Glu Gln Asp Ala Gly Gly Pro Gly Gly Ala Ala Gly 
                85                  90                  95      


Ser Pro Glu Ser Arg Ala Ser Arg Val Arg Ala Asp Glu Val Arg Leu 
            100                 105                 110         


Gln Cys Gln Ser Gly Ser Gly Phe Leu Glu Gly Leu Phe Gly Cys Leu 
        115                 120                 125             


Arg Pro Val Trp Thr Met Ile Gly Lys Ala Tyr Ser Thr Glu His Lys 
    130                 135                 140                 


Gln Gln Gln Glu Asp Leu Trp Glu Val Pro Phe Glu Glu Ile Leu Asp 
145                 150                 155                 160 


Leu Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe Leu Gly Arg 
                165                 170                 175     


Phe His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp Leu Lys Glu 
            180                 185                 190         


Thr Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn Ile Ile Thr 
        195                 200                 205             


Phe Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile Leu Met Glu 
    210                 215                 220                 


Phe Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala Gly Arg Pro 
225                 230                 235                 240 


Val Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile Ala Gly Gly 
                245                 250                 255     


Met Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp Leu Lys Ser 
            260                 265                 270         


Pro Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile Ser Asp Phe 
        275                 280                 285             


Gly Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met Ser Phe Ala 
    290                 295                 300                 


Gly Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn Glu Pro Val 
305                 310                 315                 320 


Ser Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Leu 
                325                 330                 335     


Leu Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser Ala Ile Ile 
            340                 345                 350         


Trp Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro Ser Ser Cys 
        355                 360                 365             


Pro Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn Ser Lys Pro 
    370                 375                 380                 


Arg Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu Asp Ile Ala 
385                 390                 395                 400 


Ser Ala Asp Val Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln 
                405                 410                 415     


Ala Glu Trp Arg Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser 
            420                 425                 430         


Glu Gly Thr Cys Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg 
        435                 440                 445             


Arg Glu Glu Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg 
    450                 455                 460                 


Lys Leu Glu Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met 
465                 470                 475                 480 


Leu Gln Leu Glu Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala 
                485                 490                 495     


Leu Glu Arg Arg Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly 
            500                 505                 510         


Leu Leu His Gly Asn Thr Met Glu Lys Leu Ile Lys Lys Arg Asn Val 
        515                 520                 525             


Pro Gln Lys Leu Ser Pro His Ser Lys Arg Pro Asp Ile Leu Lys Thr 
    530                 535                 540                 


Glu Ser Leu Leu Pro Lys Leu Asp Ala Ala Leu Ser Gly Val Gly Leu 
545                 550                 555                 560 


Pro Gly Cys Pro Lys Gly Pro Pro Ser Pro Gly Arg Ser Arg Arg Gly 
                565                 570                 575     


Lys Thr Arg His Arg Lys Ala Ser Ala Lys Gly Ser Cys Gly Asp Leu 
            580                 585                 590         


Pro Gly Leu Arg Thr Ala Val Pro Pro His Glu Pro Gly Gly Pro Gly 
        595                 600                 605             


Ser Pro Gly Gly Leu Gly Gly Gly Pro Ser Ala Trp Glu Ala Cys Pro 
    610                 615                 620                 


Pro Ala Leu Arg Gly Leu His His Asp Leu Leu Leu Arg Lys Met Ser 
625                 630                 635                 640 


Ser Ser Ser Pro Asp Leu Leu Ser Ala Ala Leu Gly Ser Arg Gly Arg 
                645                 650                 655     


Gly Ala Thr Gly Gly Ala Gly Asp Pro Gly Ser Pro Pro Pro Ala Arg 
            660                 665                 670         


Gly Asp Thr Pro Pro Ser Glu Gly Ser Ala Pro Gly Ser Thr Ser Pro 
        675                 680                 685             


Asp Ser Pro Gly Gly Ala Lys Gly Glu Pro Pro Pro Pro Val Gly Pro 
    690                 695                 700                 


Gly Glu Gly Val Gly Leu Leu Gly Thr Gly Arg Glu Gly Thr Ser Gly 
705                 710                 715                 720 


Arg Gly Gly Ser Arg Ala Gly Ser Gln His Leu Thr Pro Ala Ala Leu 
                725                 730                 735     


Leu Tyr Arg Ala Ala Val Thr Arg Ser Gln Lys Arg Gly Ile Ser Ser 
            740                 745                 750         


Glu Glu Glu Glu Gly Glu Val Asp Ser Glu Val Glu Leu Thr Ser Ser 
        755                 760                 765             


Gln Arg Trp Pro Gln Ser Leu Asn Met Arg Gln Ser Leu Ser Thr Phe 
    770                 775                 780                 


Ser Ser Glu Asn Pro Ser Asp Gly Glu Glu Gly Thr Ala Ser Glu Pro 
785                 790                 795                 800 


Ser Pro Ser Gly Thr Pro Glu Val Gly Ser Thr Asn Thr Asp Glu Arg 
                805                 810                 815     


Pro Asp Glu Arg Ser Asp Asp Met Cys Ser Gln Gly Ser Glu Ile Pro 
            820                 825                 830         


Leu Asp Pro Pro Pro Ser Glu Val Ile Pro Gly Pro Glu Pro Ser Ser 
        835                 840                 845             


Leu Pro Ile Pro His Gln Glu Leu Leu Arg Glu Arg Gly Pro Pro Asn 
    850                 855                 860                 


Ser Glu Asp Ser Asp Cys Asp Ser Thr Glu Leu Asp Asn Ser Asn Ser 
865                 870                 875                 880 


Val Asp Ala Leu Arg Pro Pro Ala Ser Leu Pro Pro 
                885                 890         


<210>  3
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln Ala Glu Trp Arg 
1               5                   10                  15      


Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser Glu Gly Thr Cys 
            20                  25                  30          


Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg Arg Glu Glu Leu 
        35                  40                  45              


Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg Lys Leu Glu Arg 
    50                  55                  60                  


Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met Leu Gln Leu Glu 
65                  70                  75                  80  


Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala Leu Glu Arg Arg 
                85                  90                  95      


Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly Leu Leu His Gly 
            100                 105                 110         


Asn Thr Met Glu 
        115     


<210>  4
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser Glu Gly Thr 
1               5                   10                  15      


Cys Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg Arg Glu Glu 
            20                  25                  30          


Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg Lys Leu Glu 
        35                  40                  45              


Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met Leu Gln Leu 
    50                  55                  60                  


Glu Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala Leu Glu Arg 
65                  70                  75                  80  


Arg 
    


<210>  5
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Leu Asp Leu Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe 
1               5                   10                  15      


Leu Gly Arg Phe His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp 
            20                  25                  30          


Leu Lys Glu Thr Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn 
        35                  40                  45              


Ile Ile Thr Phe Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile 
    50                  55                  60                  


Leu Met Glu Phe Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala 
65                  70                  75                  80  


Gly Arg Pro Val Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile 
                85                  90                  95      


Ala Gly Gly Met Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp 
            100                 105                 110         


Leu Lys Ser Pro Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile 
        115                 120                 125             


Ser Asp Phe Gly Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met 
    130                 135                 140                 


Ser Phe Ala Gly Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn 
145                 150                 155                 160 


Glu Pro Val Ser Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu 
                165                 170                 175     


Trp Glu Leu Leu Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser 
            180                 185                 190         


Ala Ile Ile Trp Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro 
        195                 200                 205             


Ser Ser Cys Pro Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn 
    210                 215                 220                 


Ser Lys Pro Arg Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu 
225                 230                 235                 240 


Asp Ile 
        


<210>  6
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab protein sequence

<400>  6

Arg Glu Glu Val Glu Leu Glu Phe Glu Lys Ile Arg Ser Glu Gly Thr 
1               5                   10                  15      


Cys Leu Glu Arg Glu Glu Glu Glu Leu Glu Met Glu Arg Arg Glu Glu 
            20                  25                  30          


Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg Lys Leu Glu 
        35                  40                  45              


Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met Leu Gln Leu 
    50                  55                  60                  


Glu Leu Arg Glu Arg Glu Leu Glu Arg Glu Glu Gln Ala Leu Glu Arg 
65                  70                  75                  80  


Arg 
    


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab protein sequence

<400>  7

Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln Ala Glu Trp Arg 
1               5                   10                  15      


Glu Glu Val Glu Leu Glu Phe Glu Lys Ile Arg Ser Glu Gly Thr Cys 
            20                  25                  30          


Leu Glu Arg Glu Glu Glu Glu Leu Glu Met Glu Arg Arg Glu Glu Leu 
        35                  40                  45              


Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg Lys Leu Glu Arg 
    50                  55                  60                  


Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met Leu Gln Leu Glu 
65                  70                  75                  80  


Leu Arg Glu Arg Glu Leu Glu Arg Glu Glu Gln Ala Leu Glu Arg Arg 
                85                  90                  95      


Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly Leu Leu His Gly 
            100                 105                 110         


Asn Thr Met Glu 
        115     


<210>  8
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab protein sequence

<400>  8

Ile Leu Asp Leu Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe 
1               5                   10                  15      


Leu Gly Arg Phe His Gly Glu Glu Val Ala Val Ala Lys Val Arg Asp 
            20                  25                  30          


Leu Lys Glu Thr Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn 
        35                  40                  45              


Ile Ile Thr Phe Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile 
    50                  55                  60                  


Leu Met Glu Phe Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala 
65                  70                  75                  80  


Gly Arg Pro Val Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile 
                85                  90                  95      


Ala Gly Gly Met Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp 
            100                 105                 110         


Leu Lys Ser Pro Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile 
        115                 120                 125             


Ser Asp Phe Gly Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met 
    130                 135                 140                 


Ser Phe Ala Gly Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn 
145                 150                 155                 160 


Glu Pro Val Ser Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu 
                165                 170                 175     


Trp Glu Leu Leu Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser 
            180                 185                 190         


Ala Ile Ile Trp Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro 
        195                 200                 205             


Ser Ser Cys Pro Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn 
    210                 215                 220                 


Ser Lys Pro Arg Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu 
225                 230                 235                 240 


Asp Ile 
        


<210>  9
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab protein sequence


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa = Arg, His or Lys

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa = Glu or Asp

<400>  9

Arg Glu Glu Val Xaa Leu Xaa Phe Glu Lys Ile Xaa Ser Glu Gly Thr 
1               5                   10                  15      


Cys Leu Xaa Arg Xaa Glu Glu Glu Leu Xaa Met Xaa 
            20                  25              


<210>  10
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab protein sequence


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa = Arg, His or Lys

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa = Glu or Asp

<400>  10

Tyr Met Glu Leu Asn Ala Leu Met Leu Gln Leu Glu Leu Xaa Glu Arg 
1               5                   10                  15      


Glu Leu Xaa Arg Xaa Glu Gln Ala Leu Glu Arg Arg 
            20                  25              


<210>  11
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Arg Glu Glu Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu 
1               5                   10                  15      


Arg Lys Leu Glu Arg Ala Asn Asn Leu 
            20                  25  


<210>  12
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab protein sequence


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa = Arg, His or Lys

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa = Glu or Asp

<400>  12

Arg Glu Glu Val Asp Leu Asp Phe Glu Lys Ile Xaa Ser Glu Gly Thr 
1               5                   10                  15      


Cys Leu Xaa Arg Xaa Glu Glu Glu Leu Xaa Met Xaa 
            20                  25              


<210>  13
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab protein sequence


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa = Arg, His or Lys

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa = Glu or Asp

<400>  13

Arg Glu Glu Val Glu Leu Asp Phe Glu Lys Ile Xaa Ser Glu Gly Thr 
1               5                   10                  15      


Cys Leu Xaa Arg Xaa Glu Glu Glu Leu Xaa Met Xaa 
            20                  25              


<210>  14
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab protein sequence


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa = Arg, His or Lys

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa = Glu or Asp

<400>  14

Arg Glu Glu Val Asp Leu Glu Phe Glu Lys Ile Xaa Ser Glu Gly Thr 
1               5                   10                  15      


Cys Leu Xaa Arg Xaa Glu Glu Glu Leu Xaa Met Xaa 
            20                  25              


<210>  15
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab protein sequence


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa = Arg, His or Lys

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Xaa = Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa = Glu or Asp

<400>  15

Arg Glu Glu Val Glu Leu Glu Phe Glu Lys Ile Xaa Ser Glu Gly Thr 
1               5                   10                  15      


Cys Leu Xaa Arg Xaa Glu Glu Glu Leu Xaa Met Xaa 
            20                  25              


<210>  16
<211>  225
<212>  DNA
<213>  Homo sapiens

<400>  16
gtaaaactgc actttgaaaa gattaagtca gaagggacct gtctgcaccg cctagaagag       60

gaactggtga tgaggaggag ggaggagctc agacacgccc tggacatcag ggagcactat      120

gaaaggaagc tggagagagc caacaacctg tatatggaac ttaatgccct catgttgcag      180

ctggaactca aggagaggga gctgctcagg cgagagcaag cttta                      225


<210>  17
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  17
ctctccacac cccaggagac ttactttaag tcccaggcag agtggcggga agaagtaaaa       60

ctgcactttg aaaagattaa gtcagaaggg acctgtctgc accgcctaga agaggaactg      120

gtgatgagga ggagggagga gctcagacac gccctggaca tcagggagca ctatgaaagg      180

aagctggaga gagccaacaa cctgtatatg gaacttaatg ccctcatgtt gcagctggaa      240

ctcaaggaga gggagctgct caggcgagag caagctttag agcggaggtg cccaggcctg      300

ctgaagccac acccttcccg gggcctcctg catggaaaca caatggag                   348


<210>  18
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab polynucleotide sequence

<400>  18
ctctccacac cccaggagac ttactttaag tcccaggcag agtggcggga agaagtagaa       60

ctggaatttg aaaagattaa gtcagaaggg acctgtctgc accgcctaga agaggaactg      120

gtgatgagga ggagggagga gctcagacac gccctggaca tcagggagca ctatgaaagg      180

aagctggaga gagccaacaa cctgtatatg gaacttaatg ccctcatgtt gcagctggaa      240

ctcaaggaga gggagctgct caggcgagag caagctttag agcggaggtg cccaggcctg      300

ctgaagccac acccttcccg gggcctcctg catggaaaca caatggag                   348


<210>  19
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab polynucleotide sequence

<400>  19
ctctccacac cccaggagac ttactttaag tcccaggcag agtggcggga agaagtagaa       60

ctggaatttg aaaagattcg ttcagaaggg acctgtctgg aacgcgaaga agaggaactg      120

gaaatggaaa ggagggagga gctcagacac gccctggaca tcagggagca ctatgaaagg      180

aagctggaga gagccaacaa cctgtatatg gaacttaatg ccctcatgtt gcagctggaa      240

ctccgtgaga gggagctgga aagggaagag caagctttag agcggaggtg cccaggcctg      300

ctgaagccac acccttcccg gggcctcctg catggaaaca caatggag                   348


<210>  20
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab polynucleotide sequence

<400>  20
gccgccatgg cgctctccac accccaggag acttacttta agtcccaggc agagtggcgg       60

gaagaagtag aactggaatt tgaaaagatt cgttcagaag ggacctgtct ggaacgcgaa      120

gaagaggaac tggaaatgga aaggagggag gagctcagac acgccctgga catcagggag      180

cactatgaaa ggaagctgga gagagccaac aacctgtata tggaacttaa tgccctcatg      240

ttgcagctgg aactccgtga gagggagctg gaaagggaag agcaagcttt agagcggagg      300

tgcccaggcc tgctgaagcc acacccttcc cggggcctcc tgcatggaaa cacaatggag      360

taa                                                                    363


<210>  21
<211>  3097
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Expression cassette polynucleotide sequence

<400>  21
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc cctccccacc      360

cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg cggggggggg      420

gggggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      480

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      540

aaagcgaagc gcgcggcggg cgggagtcgc tgcgacgctg ccttcgcccc gtgccccgct      600

ccgccgccgc ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga      660

gcgggcggga cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggcttg      720

tttcttttct gtggctgcgt gaaagccttg aggggctccg ggagggccct ttgtgcgggg      780

ggagcggctc ggggggtgcg tgcgtgtgtg tgtgcgtggg gagcgccgcg tgcggctccg      840

cgctgcccgg cggctgtgag cgctgcgggc gcggcgcggg gctttgtgcg ctccgcagtg      900

tgcgcgaggg gagcgcggcc gggggcggtg ccccgcggtg cggggggggc tgcgagggga      960

acaaaggctg cgtgcggggt gtgtgcgtgg gggggtgagc agggggtgtg ggcgcgtcgg     1020

tcgggctgca accccccctg cacccccctc cccgagttgc tgagcacggc ccggcttcgg     1080

gtgcggggct ccgtacgggg cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc     1140

aggtgggggt gccgggcggg gcggggccgc ctcgggccgg ggagggctcg ggggaggggc     1200

gcggcggccc ccggagcgcc ggcggctgtc gaggcgcggc gagccgcagc cattgccttt     1260

tatggtaatc gtgcgagagg gcgcagggac ttcctttgtc ccaaatctgt gcggagccga     1320

aatctgggag gcgccgccgc accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg     1380

gcaggaagga aatgggcggg gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc     1440

ctctccagcc tcggggctgt ccgcgggggg acggctgcct tcggggggga cggggcaggg     1500

cggggttcgg cttctggcgt gtgaccggcg gctctagagc ctctgctaac catgttcatg     1560

ccttcttctt tttcctacag ctcctgggca acgtgctggt tattgtgctg tctcatcatt     1620

ttggcaaaga attcgagcgg ccgccagtgt gagttggacc ggtgccgcca tggcgctctc     1680

cacaccccag gagacttact ttaagtccca ggcagagtgg cgggaagaag tagaactgga     1740

atttgaaaag attcgttcag aagggacctg tctggaacgc gaagaagagg aactggaaat     1800

ggaaaggagg gaggagctca gacacgccct ggacatcagg gagcactatg aaaggaagct     1860

ggagagagcc aacaacctgt atatggaact taatgccctc atgttgcagc tggaactccg     1920

tgagagggag ctggaaaggg aagagcaagc tttagagcgg aggtgcccag gcctgctgaa     1980

gccacaccct tcccggggcc tcctgcatgg aaacacaatg gagtaatgag gcatgcttct     2040

atattatttt ctaaaagatt taaagttttg ccttctccat ttagacttat aattcactgg     2100

aatttttttg tgtgtatggt atgacatatg ggttcccttt tattttttac atataaatat     2160

atttccctgt ttttctaaaa aagacctagg aaaactgtct tcataatcaa cctctggatt     2220

acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg     2280

gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct     2340

cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc gttgtcaggc     2400

aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc cactggttgg ggcattgcca     2460

ccacctgtca gctcctttcc gggactttcg ctttccccct ccctattgcc acggcggaac     2520

tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc actgacaatt     2580

ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct gctcgcctat gttgccacct     2640

ggattctgcg cgggacgtcc ttctgctacg tcccttcggc cctcaatcca gcggaccttc     2700

cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga     2760

cgagtcggat ctccctttgg gccgcctccc cgcatcgata ccgagcgctg ctagagagat     2820

cgatctgcct caactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg     2880

ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt     2940

gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc     3000

aagggggagg attgggaaga gaatagcagg catgctgggg atgcggtggg ctctatgggt     3060

acccaggtgc tgaagaattg acccggttcc tcctggg                              3097


<210>  22
<211>  4099
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lav - Expression cassette polynucleotide sequence

<400>  22
atgtcctaca gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg       60

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact      120

ccatcactag gggttccttg tagttaatga ttaacctctg gagaccgcca tgctacttat      180

ctaccagggt aatggggatc ctctagaact atagcgttac ataacttacg gtaaatggcc      240

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      300

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      360

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      420

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      480

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc cccacgttct      540

gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta tttatttttt      600

aattattttg tgcagcgatg ggggcggggg gggggggggg gcggggcgag gggcggggcg      660

gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg cgcgctccga aagtttcctt      720

ttatggcgag gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg cgggcgggag      780

tcgctgcgac gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc      840

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      900

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc      960

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg     1020

tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc     1080

gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc     1140

ggtgccccgc ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc     1200

gtgggggggt gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc     1260

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc     1320

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg     1380

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc     1440

tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag     1500

ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc     1560

tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc     1620

cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg     1680

ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc     1740

ggcggctcta gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg     1800

ggcaacgtgc tggttattgt gctgtctcat cattttggca aagaattcga gcggccgcca     1860

gtgtgagttg gaccggtgcc gccatggcgc tctccacacc ccaggagact tactttaagt     1920

cccaggcaga gtggcgggaa gaagtagaac tggaatttga aaagattcgt tcagaaggga     1980

cctgtctgga acgcgaagaa gaggaactgg aaatggaaag gagggaggag ctcagacacg     2040

ccctggacat cagggagcac tatgaaagga agctggagag agccaacaac ctgtatatgg     2100

aacttaatgc cctcatgttg cagctggaac tccgtgagag ggagctggaa agggaagagc     2160

aagctttaga gcggaggtgc ccaggcctgc tgaagccaca cccttcccgg ggcctcctgc     2220

atggaaacac aatggagtaa tgaggcatgc ttctatatta ttttctaaaa gatttaaagt     2280

tttgccttct ccatttagac ttataattca ctggaatttt tttgtgtgta tggtatgaca     2340

tatgggttcc cttttatttt ttacatataa atatatttcc ctgtttttct aaaaaagacc     2400

taggaaaact gtcttcataa tcaacctctg gattacaaaa tttgtgaaag attgactggt     2460

attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat     2520

catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg     2580

tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt     2640

gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact     2700

ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc     2760

tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaaatcatcg     2820

tcctttcctt ggctgctcgc ctatgttgcc acctggattc tgcgcgggac gtccttctgc     2880

tacgtccctt cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg     2940

cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc     3000

tccccgcatc gataccgagc gctgctagag agatcgatct gcctcaactg tgccttctag     3060

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     3120

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     3180

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagagaatag     3240

caggcatgct ggggatgcgg tgggctctat gggtacccag gtgctgaaga attgacccgg     3300

ttcctcctgg ggaagcaatt cgttgatctg aatttcgacc accgataata cctattaccc     3360

tggtagataa gtagcacggc gggttaatga ttaactacag caattcgttg atctgaattt     3420

cgaccaccca taatagatct cccattaccc tggtagataa gtagcatggc gggacaatta     3480

agtacctcaa agaactattc ttgtttgcct tattcctatg taaataactg aaatctttgt     3540

ttttcttcct aaaaggggtg atgttgattt ttacttacaa tgtattttaa gtttgtcact     3600

ctaaatggtt atgagcaagt ttaagaaaaa tcttcagcaa atactacctt agattatgac     3660

cccaaaacac atttacttat gattatgttg aaaacatagg gtctggggaa aaagggattt     3720

aaattaagaa gaaaaagaag acttcggact taaaaagtct tttagaggcc agctcaccaa     3780

caacacaaca ccgagtctgt gttgcacaat atgttactta ggtataaatc aaggattcat     3840

gtaattttgt cattccttgc gtgatatttt aaaaaacatt ctgtgtaagg tatttataaa     3900

gctctcttct aaaaatacaa aaatttgtgt cattaatcaa cagtcaggtt aatcattaac     3960

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4020

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4080

gagcgagcgc gcactgtca                                                  4099


<210>  23
<211>  89
<212>  RNA
<213>  Homo sapiens

<400>  23
ugcugcuggc cagagcucuu uucacauugu gcuacugucu gcaccuguca cuagcagugc       60

aauguuaaaa gggcauuggc cguguagug                                         89


<210>  24
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  24
uacccuguag auccgaauuu gug                                               23


<210>  25
<211>  24
<212>  RNA
<213>  Homo sapiens

<400>  25
uuaaugcuaa ucgugauagg gguu                                              24


<210>  26
<211>  71
<212>  RNA
<213>  Homo sapiens

<400>  26
gcgacuguaa acauccucga cuggaagcug ugaagccaca gaugggcuuu cagucggaug       60

uuugcagcug c                                                            71


