                         SEQUENCE LISTING

<110>  BioMadison, INc.
 
<120>  Compositions and Methods for Protease Screening

<130>  102320.0026PCT

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SNAP-25 fragment (141 to 193)

<400>  1

Ala Arg Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile 
1               5                   10                  15      


Ile Gly Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp 
            20                  25                  30          


Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly 
    50                  55                  60                  


Ser Gly 
65      


<210>  2
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SNAP-23 fragment (141 to 193)

<400>  2

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Thr Asn 
        35                  40                  45              


Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  3
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SNAP-2325 chimeric reporting construct 1

<400>  3

Met Gly Gly Ser His His His His His His Gly Met Ala Ser Arg Leu 
1               5                   10                  15      


Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            20                  25                  30          


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        35                  40                  45              


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
    50                  55                  60                  


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
65                  70                  75                  80  


Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro 
                85                  90                  95      


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            100                 105                 110         


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
        115                 120                 125             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    130                 135                 140                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
145                 150                 155                 160 


Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp 
                165                 170                 175     


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile 
            180                 185                 190         


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        195                 200                 205             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    210                 215                 220                 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
225                 230                 235                 240 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
                245                 250                 255     


Leu Tyr Lys Ser Gly Leu Arg Ser Arg Ala Arg Glu Asp Glu Met Glu 
            260                 265                 270         


Glu Asn Leu Thr Gln Val Gly Ser Ile Leu Gly Asn Leu Lys Asp Met 
        275                 280                 285             


Ala Leu Asn Ile Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp 
    290                 295                 300                 


Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu Ala 
305                 310                 315                 320 


Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ser Asn Ser Gly Gly 
                325                 330                 335     


Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
            340                 345                 350         


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
        355                 360                 365             


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu 
    370                 375                 380                 


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
385                 390                 395                 400 


Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met 
                405                 410                 415     


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
            420                 425                 430         


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
        435                 440                 445             


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
    450                 455                 460                 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
465                 470                 475                 480 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys 
                485                 490                 495     


Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
            500                 505                 510         


Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
        515                 520                 525             


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala 
    530                 535                 540                 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
545                 550                 555                 560 


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                565                 570                 575     


Ser Trp Ser His Pro Gln Phe Glu Lys 
            580                 585 


<210>  4
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SNAP-2325 chimeric reporting construct 2

<400>  4

Met Gly Gly Ser His His His His His His Gly Met Ala Ser Arg Leu 
1               5                   10                  15      


Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            20                  25                  30          


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        35                  40                  45              


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
    50                  55                  60                  


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
65                  70                  75                  80  


Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro 
                85                  90                  95      


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            100                 105                 110         


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
        115                 120                 125             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    130                 135                 140                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
145                 150                 155                 160 


Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp 
                165                 170                 175     


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile 
            180                 185                 190         


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        195                 200                 205             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    210                 215                 220                 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
225                 230                 235                 240 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
                245                 250                 255     


Leu Tyr Lys Ser Gly Leu Arg Ser Arg Ala Arg Glu Asp Glu Met Glu 
            260                 265                 270         


Glu Asn Leu Thr Gln Val Gly Ser Ile Leu Gly Asn Leu Lys Asp Met 
        275                 280                 285             


Ala Leu Asn Ile Gly Asn Glu Ile Asp Ala Gln Asn Pro Gln Ile Lys 
    290                 295                 300                 


Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu Ala 
305                 310                 315                 320 


Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ser Asn Ser Gly Gly 
                325                 330                 335     


Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
            340                 345                 350         


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
        355                 360                 365             


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu 
    370                 375                 380                 


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
385                 390                 395                 400 


Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met 
                405                 410                 415     


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
            420                 425                 430         


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
        435                 440                 445             


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
    450                 455                 460                 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
465                 470                 475                 480 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys 
                485                 490                 495     


Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
            500                 505                 510         


Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
        515                 520                 525             


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala 
    530                 535                 540                 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
545                 550                 555                 560 


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                565                 570                 575     


Ser Trp Ser His Pro Gln Phe Glu Lys 
            580                 585 


<210>  5
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SNAP 2325 chimeric reporting construct 3

<400>  5

Met Gly Gly Ser His His His His His His Gly Met Ala Ser Arg Leu 
1               5                   10                  15      


Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            20                  25                  30          


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        35                  40                  45              


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
    50                  55                  60                  


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
65                  70                  75                  80  


Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro 
                85                  90                  95      


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            100                 105                 110         


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
        115                 120                 125             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    130                 135                 140                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
145                 150                 155                 160 


Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp 
                165                 170                 175     


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile 
            180                 185                 190         


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        195                 200                 205             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    210                 215                 220                 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
225                 230                 235                 240 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
                245                 250                 255     


Leu Tyr Lys Ser Gly Leu Arg Ser Arg Ala Arg Glu Asp Glu Met Glu 
            260                 265                 270         


Glu Asn Leu Thr Gln Val Gly Ser Ile Leu Gly Asn Leu Lys Asp Met 
        275                 280                 285             


Ala Leu Asn Ile Gly Asn Glu Ile Asp Ala Gln Asn Pro Gln Ile Lys 
    290                 295                 300                 


Arg Ile Thr Asp Lys Ala Asp Thr Asn Arg Asp Arg Ile Asp Glu Ala 
305                 310                 315                 320 


Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ser Asn Ser Gly Gly 
                325                 330                 335     


Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
            340                 345                 350         


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
        355                 360                 365             


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu 
    370                 375                 380                 


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
385                 390                 395                 400 


Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met 
                405                 410                 415     


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
            420                 425                 430         


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
        435                 440                 445             


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
    450                 455                 460                 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
465                 470                 475                 480 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys 
                485                 490                 495     


Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
            500                 505                 510         


Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
        515                 520                 525             


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala 
    530                 535                 540                 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
545                 550                 555                 560 


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                565                 570                 575     


Ser Trp Ser His Pro Gln Phe Glu Lys 
            580                 585 


<210>  6
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate 1

<400>  6

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly 
    50                  55                  60                  


Ser Gly 
65      


<210>  7
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate 2

<400>  7

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Ser Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly 
    50                  55                  60                  


Ser Gly 
65      


<210>  8
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate 3

<400>  8

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Thr Asn 
        35                  40                  45              


Arg Asp Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly 
    50                  55                  60                  


Ser Gly 
65      


<210>  9
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate 4

<400>  9

Ala Arg Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile 
1               5                   10                  15      


Ile Gly Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Thr Asn 
        35                  40                  45              


Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  10
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate 5

<400>  10

Ala Arg Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile 
1               5                   10                  15      


Ile Gly Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp 
            20                  25                  30          


Thr Gln Asn Arg Gln Ile Asp Arg Ile Thr Asp Lys Ala Asp Thr Asn 
        35                  40                  45              


Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  11
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate 6

<400>  11

Ala Arg Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile 
1               5                   10                  15      


Ile Gly Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp 
            20                  25                  30          


Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  12
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X1

<400>  12

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn 
        35                  40                  45              


Lys Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  13
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X2

<400>  13

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn 
        35                  40                  45              


Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  14
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X3

<400>  14

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Thr Asn 
        35                  40                  45              


Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  15
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X4

<400>  15

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Thr Asn 
        35                  40                  45              


Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  16
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X5

<400>  16

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Thr Gln Asn Arg Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Thr Asn 
        35                  40                  45              


Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  17
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X6

<400>  17

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Thr Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Thr Asn 
        35                  40                  45              


Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  18
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X7

<400>  18

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Thr Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  19
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X8

<400>  19

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Thr Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  20
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X9

<400>  20

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Ser Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  21
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X10

<400>  21

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Pro Gln Ile Lys Arg Ile Met Glu Lys Ala Asp Ser Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  22
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X11

<400>  22

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Pro Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  23
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X12

<400>  23

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


<210>  24
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric peptide substrate X13

<400>  24

Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile 
1               5                   10                  15      


Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp 
            20                  25                  30          


Ala Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn 
        35                  40                  45              


Lys Thr Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp 
    50                  55                  60                  


Ser 
65  


