                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Inc.
 
<120>  Targeting Lung-Resident TNFR2+cDC2 (R2D2) Subpopulation to Treat 
       Asthma

<130>  10457-413PC0

<140>  PCT/US2020/018037
<141>  2020-02-13

<150>  62805074
<151>  2019-02-13

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  839
<212>  DNA
<213>  Homo sapiens

<400>  1
attctaactg caacctttcg aagcctttgc tctggcacaa caggtagtag gcgacactgt       60

tcgtgttgtc aacatgacca acaagtgtct cctccaaatt gctctcctgt tgtgcttctc      120

cactacagct ctttccatga gctacaactt gcttggattc ctacaaagaa gcagcaattt      180

tcagtgtcag aagctcctgt ggcaattgaa tgggaggctt gaatactgcc tcaaggacag      240

gatgaacttt gacatccctg aggagattaa gcagctgcag cagttccaga aggaggacgc      300

cgcattgacc atctatgaga tgctccagaa catctttgct attttcagac aagattcatc      360

tagcactggc tggaatgaga ctattgttga gaacctcctg gctaatgtct atcatcagat      420

aaaccatctg aagacagtcc tggaagaaaa actggagaaa gaagatttca ccaggggaaa      480

actcatgagc agtctgcacc tgaaaagata ttatgggagg attctgcatt acctgaaggc      540

caaggagtac agtcactgtg cctggaccat agtcagagtg gaaatcctaa ggaactttta      600

cttcattaac agacttacag gttacctccg aaactgaaga tctcctagcc tgtgcctctg      660

ggactggaca attgcttcaa gcattcttca accagcagat gctgtttaag tgactgatgg      720

ctaatgtact gcatatgaaa ggacactaga agattttgaa atttttatta aattatgagt      780

tatttttatt tatttaaatt ttattttgga aaataaatta tttttggtgc aaaagtcaa       839


<210>  2
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln 
1               5                   10                  15      


Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu 
            20                  25                  30          


Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln 
        35                  40                  45              


Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met Leu Gln 
    50                  55                  60                  


Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn 
65                  70                  75                  80  


Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn 
                85                  90                  95      


His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr 
            100                 105                 110         


Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg 
        115                 120                 125             


Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr 
    130                 135                 140                 


Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu 
145                 150                 155                 160 


Thr Gly Tyr Leu Arg Asn 
                165     


<210>  3
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  4
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln 
1               5                   10                  15      


Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu 
            20                  25                  30          


Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln 
        35                  40                  45              


Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met Leu Gln 
    50                  55                  60                  


Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn 
65                  70                  75                  80  


Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn 
                85                  90                  95      


His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr 
            100                 105                 110         


Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg 
        115                 120                 125             


Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr 
    130                 135                 140                 


Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu 
145                 150                 155                 160 


Thr Gly Tyr Leu Arg Asn 
                165     


<210>  5
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe 
    130                 135                 140                 


Arg Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


<210>  6
<211>  161
<212>  PRT
<213>  Mus musculus

<400>  6

Ile Asn Tyr Lys Gln Leu Gln Leu Gln Glu Arg Thr Asn Ile Arg Lys 
1               5                   10                  15      


Cys Gln Glu Leu Leu Glu Gln Leu Asn Gly Lys Ile Asn Leu Thr Tyr 
            20                  25                  30          


Arg Ala Asp Phe Lys Ile Pro Met Glu Met Thr Glu Lys Met Gln Lys 
        35                  40                  45              


Ser Tyr Thr Ala Phe Ala Ile Gln Glu Met Leu Gln Asn Val Phe Leu 
    50                  55                  60                  


Val Phe Arg Asn Asn Phe Ser Ser Thr Gly Trp Asn Glu Thr Ile Val 
65                  70                  75                  80  


Val Arg Leu Leu Asp Glu Leu His Gln Gln Thr Val Phe Leu Lys Thr 
                85                  90                  95      


Val Leu Glu Glu Lys Gln Glu Glu Arg Leu Thr Trp Glu Met Ser Ser 
            100                 105                 110         


Thr Ala Leu His Leu Lys Ser Tyr Tyr Trp Arg Val Gln Arg Tyr Leu 
        115                 120                 125             


Lys Leu Met Lys Tyr Asn Ser Tyr Ala Trp Met Val Val Arg Ala Glu 
    130                 135                 140                 


Ile Phe Arg Asn Phe Leu Ile Ile Arg Arg Leu Thr Arg Asn Phe Gln 
145                 150                 155                 160 


Asn 
    


<210>  7
<211>  156
<212>  PRT
<213>  Mus musculus

<400>  7

Leu Arg Ser Ser Ser Gln Asn Ser Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser 
65                  70                  75                  80  


Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val 
                85                  90                  95      


Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro 
            100                 105                 110         


Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly 
        115                 120                 125             


Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg 
    130                 135                 140                 


Glu Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
145                 150                 155     


<210>  8
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Thr Glu Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala Leu 
1               5                   10                  15      


Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe Leu 
            20                  25                  30          


Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe Cys 
        35                  40                  45              


Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro Arg 
    50                  55                  60                  


Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser 
65                  70                  75                  80  


Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
                85                  90                  95      


Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
            100                 105                 110         


Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
        115                 120                 125             


Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
    130                 135                 140                 


Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
145                 150                 155                 160 


Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
                165                 170                 175     


Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
            180                 185                 190         


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
        195                 200                 205             


Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly Gln 
    210                 215                 220                 


Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230         


<210>  9
<211>  182
<212>  PRT
<213>  Mus musculus

<400>  9

Met Asn Asn Arg Trp Ile Leu His Ala Ala Phe Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Ile Asn Tyr Lys Gln Leu Gln Leu Gln Glu Arg 
            20                  25                  30          


Thr Asn Ile Arg Lys Cys Gln Glu Leu Leu Glu Gln Leu Asn Gly Lys 
        35                  40                  45              


Ile Asn Leu Thr Tyr Arg Ala Asp Phe Lys Ile Pro Met Glu Met Thr 
    50                  55                  60                  


Glu Lys Met Gln Lys Ser Tyr Thr Ala Phe Ala Ile Gln Glu Met Leu 
65                  70                  75                  80  


Gln Asn Val Phe Leu Val Phe Arg Asn Asn Phe Ser Ser Thr Gly Trp 
                85                  90                  95      


Asn Glu Thr Ile Val Val Arg Leu Leu Asp Glu Leu His Gln Gln Thr 
            100                 105                 110         


Val Phe Leu Lys Thr Val Leu Glu Glu Lys Gln Glu Glu Arg Leu Thr 
        115                 120                 125             


Trp Glu Met Ser Ser Thr Ala Leu His Leu Lys Ser Tyr Tyr Trp Arg 
    130                 135                 140                 


Val Gln Arg Tyr Leu Lys Leu Met Lys Tyr Asn Ser Tyr Ala Trp Met 
145                 150                 155                 160 


Val Val Arg Ala Glu Ile Phe Arg Asn Phe Leu Ile Ile Arg Arg Leu 
                165                 170                 175     


Thr Arg Asn Phe Gln Asn 
            180         


<210>  10
<211>  235
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Gln Lys Met Gly Gly Phe Gln Asn Ser Arg Arg Cys Leu Cys 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Leu Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu Asn Phe Gly Val Ile Gly Pro Gln Arg Asp Glu Lys Phe 
    50                  55                  60                  


Pro Asn Gly Leu Pro Leu Ile Ser Ser Met Ala Gln Thr Leu Thr Leu 
65                  70                  75                  80  


Arg Ser Ser Ser Gln Asn Ser Ser Asp Lys Pro Val Ala His Val Val 
                85                  90                  95      


Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala 
            100                 105                 110         


Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val 
        115                 120                 125             


Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys 
    130                 135                 140                 


Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg 
145                 150                 155                 160 


Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys 
                165                 170                 175     


Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp 
            180                 185                 190         


Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp 
        195                 200                 205             


Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg Glu 
    210                 215                 220                 


Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
225                 230                 235 


