                         SEQUENCE LISTING

<110>  Emory University
 
<120>  CHIMERIC RSV AND HMPV F PROTEINS, IMMUNOGENIC COMPOSITIONS, AND 
       METHODS OF USE

<130>  10029-064WO1

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Glu Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Lys Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Ile Met Ile Thr Thr Ile Ile 
                485                 490                 495     


Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val Gly Leu Leu 
            500                 505                 510         


Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser Lys Asp Gln 
        515                 520                 525             


Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
    530                 535                 


<210>  2
<211>  1620
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
atgtcctgga aagtggtgat cattttttca ttgctaataa cacctcaaca cggtcttaaa       60

gagagctact tggaagaatc atgtagcact ataactgagg ggtatctcag tgttctgagg      120

acaggttggt ataccaacgt ttttacatta gaggtgggtg atgtagaaaa cctcacatgt      180

gctgatggac ctagcctaat aaaaacagaa ttagaactga ccaaaagtgc actaagagag      240

ctcaaaacag tctctgctga ccaattggcg agagaggaac aaattgagaa tcccagaaga      300

agaagatttg ttctaggagc aatagcactc ggtgttgcaa cagcagctgc agttacagca      360

ggtgttgcaa ttgccaaaac catccggctt gagagtgaag tcacagcaat taagaatgcc      420

cttaaaaaga ccaatgaagc agtatctaca ttggggaatg gagttcgagt gttggcaact      480

gcagtaagag agctgaaaga ttttgtgagc aagaatttaa ctcgtgcaat caacaaaaac      540

aagtgcgaca ttgatgacct aaaaatggcc gttagcttca gtcaattcaa cagaaggttt      600

ctaaatgttg tgcggcaatt ttcagacaat gctggaataa caccagcaat atctttggac      660

ttaatgacag atgctgaact agccagggcc gtctccaaca tgccgacatc tgcaggacaa      720

ataaaattga tgttggagaa ccgtgcaatg gtgcgaagaa aggggtttgg aatcctgata      780

ggggtctacg ggagctccgt aatttacatg gtgcagctgc caatctttgg cgtcatagac      840

acgccttgct ggatagtaaa agcagccccc tcttgttcca aaaaaaaggg aaactatgct      900

tgccttttaa gagaagatca agggtggtat tgtcagaatg cagggtcaac tgtttactac      960

ccaaatgaga aagactgtga aacaagagga gaccatgtct tttgcgacac agcagcagga     1020

attaatgttg ctgagcaatc aaaagagtgc aatatcaaca tatccactac aaattaccca     1080

tgcaaagtca gcacaggaag acatcctatc agtatggttg cactgtctcc tcttggggct     1140

ctagttgctt gctacaaagg agtaagctgt tccattggca gcaatagagt agggatcatc     1200

aagcagctga acaaaggttg ctcctatata accaaccaag atgcagacac agtgacaata     1260

gacaacactg tatatcagct aagcaaagtt gagggtgaac agcatgttat aaaaggcaga     1320

ccagtgtcaa gcagctttga tccagtcaag tttcctgaag atcaattcaa tgttgcactt     1380

gaccaagttt ttgagaacat tgaaaacagc caggccttgg tggatcaatc aaacaggatc     1440

ctaagcagtg cagagaaagg gaacactatc atgataacta ctataattat agtgattata     1500

gtaatattgt tatcattaat tgctgttgga ctgctcctat actgtaaggc cagaagcaca     1560

ccagtcacac taagcaagga tcaactgagt ggtataaata atattgcatt tagtaactga     1620


<210>  3
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
atgggttcga attcgctatc gatgataaaa gtacgtctac aaaatctatt tgataatgat       60

gaagtagcgc tactaaaaat aacgtgttat acggataaac taatacatct aacgaatgcg      120

ctagcgaaag cggtaataca tacgataaaa ctaaatggta tagtatttgt acatgtaata      180

acgtcgtcgg atatatgtcc gaataataat atagtagtaa aatcgaattt tacgacgatg      240

ccggtactac aaaatggtgg ttatatatgg gaaatgatgg aactaacgca ttgttcgcaa      300

ccgaatggtc tactagatga taattgtgaa ataaaatttt cgaaaaaact atcggattcg      360

acgatgacga attatatgaa tcaactatcg gaactactag gttttgatct aaatccgtaa      420


<210>  4
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
atggatacga cgcataatga taatacgccg caacgtctaa tgataacgga tatgcgtccg       60

ctatcgctag aaacgataat aacgtcgcta acgcgtgata taataacgca taaatttata      120

tatctaataa atcatgaatg tatagtacgt aaactagatg aacgtcaagc gacgtttacg      180

tttctagtaa attatgaaat gaaactacta cataaagtag gttcgacgaa atataaaaaa      240

tatacggaat ataatacgaa atatggtacg tttccgatgc cgatatttat aaatcatgat      300

ggttttctag aatgtatagg tataaaaccg acgaaacata cgccgataat atataaatat      360

gatctaaatc cgtaa                                                       375


<210>  5
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Glu Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Lys Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Gln Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  6
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  X is A or T

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is E or D

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  X is R or Q

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  X is R or S

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  X is L or F

<220>
<221>  MISC_FEATURE
<222>  (122)..(122)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (135)..(135)
<223>  X is T or N

<220>
<221>  MISC_FEATURE
<222>  (139)..(139)
<223>  X is N or G

<220>
<221>  MISC_FEATURE
<222>  (167)..(167)
<223>  X is E or D

<220>
<221>  MISC_FEATURE
<222>  (175)..(175)
<223>  X is R or S

<220>
<221>  MISC_FEATURE
<222>  (185)..(185)
<223>  X is A or D

<220>
<221>  MISC_FEATURE
<222>  (233)..(233)
<223>  X is V or Y

<220>
<221>  MISC_FEATURE
<222>  (286)..(286)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (294)..(294)
<223>  X is K or E

<220>
<221>  MISC_FEATURE
<222>  (296)..(296)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (312)..(312)
<223>  X is Q or K

<220>
<221>  MISC_FEATURE
<222>  (348)..(348)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (404)..(404)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (444)..(444)
<223>  X is S or N

<220>
<221>  MISC_FEATURE
<222>  (449)..(449)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (450)..(450)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (470)..(470)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (482)..(482)
<223>  X is S or N

<400>  6

Met Ser Trp Lys Val Val Xaa Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Xaa Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Xaa Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Xaa Xaa Arg Phe Val Leu Gly Ala Ile Ala Xaa Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Xaa Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Xaa Ala Ile Lys Xaa Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Xaa Phe Val Ser Lys Asn Leu Thr Xaa Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Xaa Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Xaa Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Xaa Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Xaa Lys Xaa Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Xaa Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Xaa Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Xaa Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Xaa Ser Phe Asp Pro 
        435                 440                 445             


Xaa Xaa Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Xaa Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Xaa Ser Ala Glu Lys Gly Asn Thr 
                485                 


<210>  7
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is S or L

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is V or I

<400>  7

Xaa Met Ile Thr Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Xaa 
1               5                   10                  15      


Leu Ile Ala Val Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro 
            20                  25                  30          


Xaa Thr Leu Ser Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe 
        35                  40                  45              


Ser Asn 
    50  


<210>  8
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Glu Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Lys Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr 
                485                 


<210>  9
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Arg Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Lys Ile 
465                 470                 475                 480 


Leu Asn Ser Ala Glu Lys Gly Asn Thr 
                485                 


<210>  10
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Met Ile Thr Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser 
1               5                   10                  15      


Leu Ile Ala Val Gly Leu Leu Leu 
            20                  


<210>  11
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  11

Ile Met Ile Thr Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser 
1               5                   10                  15      


Leu Ile Ala Val Gly Leu Leu Leu Tyr Cys 
            20                  25      


<210>  12
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  12

Ile Met Ile Thr Ala Ile Ile Ile Val Ile Ile Val Val Leu Leu Ser 
1               5                   10                  15      


Leu Ile Ala Ile Gly Leu Leu Leu Tyr Cys 
            20                  25      


<210>  13
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  13

Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser Lys Asp Gln Leu 
1               5                   10                  15      


Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
            20                  25      


<210>  14
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  14

Lys Ala Arg Ser Thr Pro Val Thr Leu Ser Lys Asp Gln Leu Ser Gly 
1               5                   10                  15      


Ile Asn Asn Ile Ala Phe Ser Asn 
            20                  


<210>  15
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  15

Tyr Cys Lys Ala Lys Asn Thr Pro Val Thr Leu Ser Lys Asp Gln Leu 
1               5                   10                  15      


Ser Gly Ile Asn Asn Ile Ala Phe Ser Lys 
            20                  25      


<210>  16
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Ala Lys Asn Thr Pro Val Thr Leu Ser Lys Asp Gln Leu Ser Gly 
1               5                   10                  15      


Ile Asn Asn Ile Ala Phe Ser Lys 
            20                  


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17

Arg Gln Ser Arg 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18

Arg Arg Arg Arg 
1               


<210>  19
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Glu Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Lys Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Gln Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  20
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Pro Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Thr Ala Val Leu Gly Ser Thr Met Ile Leu Val Ser Val Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Asn 
    530                 535                 


<210>  21
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Gln Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asn Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Gly His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Arg Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Asn Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Val Ala Val Leu Gly Leu Thr Met Ile Ser Val Ser Ile Ile Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Lys Gly Ala Pro Pro Glu Leu Asn 
        515                 520                 525             


Gly Val Thr Asn Gly Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  22
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Arg Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Lys Ile 
465                 470                 475                 480 


Leu Asn Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Leu Thr Met Ile Ser Val Ser Ile Ile Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Arg Lys Pro Thr Gly Ala Pro Pro Glu Leu Asn 
        515                 520                 525             


Gly Val Thr Asn Gly Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  23
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Glu Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Gln Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  24
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Val Leu Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  25
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Asn Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  26
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Trp Lys Val Val Val Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Val Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  27
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Arg Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Val Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  28
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Phe Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  29
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Arg Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Ser Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  30
<211>  14880
<212>  DNA
<213>  Homo sapiens

<400>  30
acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt       60

tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga      120

tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa      180

cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata      240

cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga      300

ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt      360

atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata      420

attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc      480

aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc      540

aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc      600

aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa      660

cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg      720

cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa      780

ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat      840

aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt      900

ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg      960

aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca     1020

cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa     1080

aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga     1140

tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca     1200

gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc     1260

agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat     1320

tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa     1380

aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc     1440

gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa     1500

ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag     1560

aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat     1620

tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag     1680

ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac     1740

tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag     1800

atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag     1860

ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg     1920

gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa     1980

tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct     2040

accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct     2100

ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac     2160

cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg     2220

gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc     2280

agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa     2340

tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta     2400

aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata     2460

gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa     2520

attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt     2580

atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt     2640

ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt     2700

catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg     2760

atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac     2820

ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag     2880

aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca     2940

ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa     3000

catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg     3060

aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca     3120

aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca     3180

aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa     3240

aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat     3300

acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa     3360

tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta     3420

atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga     3480

taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg     3540

tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg     3600

catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta     3660

tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa     3720

catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc     3780

tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa     3840

tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca     3900

aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa     3960

gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca     4020

tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac     4080

attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact     4140

tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt     4200

aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtcca aaaacaagga     4260

ccaacgcacc gctaagacat tagaaaggac ctgggacact ctcaatcatt tattattcat     4320

atcatcgtgc ttatataagt taaatcttaa atctgtagca caaatcacat tatccattct     4380

ggcaatgata atctcaactt cacttataat tgcagccatc atattcatag cctcggcaaa     4440

ccacaaagtc acaccaacaa ctgcaatcat acaagatgca acaagccaga tcaagaacac     4500

aaccccaaca tacctcaccc agaatcctca gcttggaatc agtccctcta atccgtctga     4560

aattacatca caaatcacca ccatactagc ttcaacaaca ccaggagtca agtcaaccct     4620

gcaatccaca acagtcaaga ccaaaaacac aacaacaact caaacacaac ccagcaagcc     4680

caccacaaaa caacgccaaa acaaaccacc aagcaaaccc aataatgatt ttcactttga     4740

agtgttcaac tttgtaccct gcagcatatg cagcaacaat ccaacctgct gggctatctg     4800

caaaagaata ccaaacaaaa aaccaggaaa gaaaaccact accaagccca caaaaaaacc     4860

aaccctcaag acaaccaaaa aagatcccaa acctcaaacc actaaatcaa aggaagtacc     4920

caccaccaag cccacagaag agccaaccat caacaccacc aaaacaaaca tcataactac     4980

actactcacc tccaacacca caggaaatcc agaactcaca agtcaaatgg aaaccttcca     5040

ctcaacttcc tccgaaggca atccaagccc ttctcaagtc tctacaacat ccgagtaccc     5100

atcacaacct tcatctccac ccaacacacc acgccagtag ttacttaaaa acatattatc     5160

acaaaaggcc ttgaccaacc gcggagaatc aaaataaact ctggggcaaa taacaatgtc     5220

ctggaaagtg gtgatcattt tttcattgct aataacacct caacacggtc ttaaagagag     5280

ctacttggaa gaatcatgta gcactataac tgaggggtat ctcagtgttc tgaggacagg     5340

ttggtatacc aacgttttta cattagaggt gggtgatgta gaaaacctca catgtgctga     5400

tggacctagc ctaataaaaa cagaattaga actgaccaaa agtgcactaa gagagctcaa     5460

aacagtctct gctgaccaat tggcgagaga ggaacaaatt gagaatccca gaagaagaag     5520

atttgttcta ggagcaatag cactcggtgt tgcaacagca gctgcagtta cagcaggtgt     5580

tgcaattgcc aaaaccatcc ggcttgagag tgaagtcaca gcaattaaga atgcccttaa     5640

aaagaccaat gaagcagtat ctacattggg gaatggagtt cgagtgttgg caactgcagt     5700

aagagagctg aaagattttg tgagcaagaa tttaactcgt gcaatcaaca aaaacaagtg     5760

cgacattgat gacctaaaaa tggccgttag cttcagtcaa ttcaacagaa ggtttctaaa     5820

tgttgtgcgg caattttcag acaatgctgg aataacacca gcaatatctt tggacttaat     5880

gacagatgct gaactagcca gggccgtctc caacatgccg acatctgcag gacaaataaa     5940

attgatgttg gagaaccgtg caatggtgcg aagaaagggg tttggaatcc tgataggggt     6000

ctacgggagc tccgtaattt acatggtgca gctgccaatc tttggcgtca tagacacgcc     6060

ttgctggata gtaaaagcag ccccctcttg ttccaaaaaa aagggaaact atgcttgcct     6120

tttaagagaa gatcaagggt ggtattgtca gaatgcaggg tcaactgttt actacccaaa     6180

tgagaaagac tgtgaaacaa gaggagacca tgtcttttgc gacacagcag caggaattaa     6240

tgttgctgag caatcaaaag agtgcaatat caacatatcc actacaaatt acccatgcaa     6300

agtcagcaca ggaagacatc ctatcagtat ggttgcactg tctcctcttg gggctctagt     6360

tgcttgctac aaaggagtaa gctgttccat tggcagcaat agagtaggga tcatcaagca     6420

gctgaacaaa ggttgctcct atataaccaa ccaagatgca gacacagtga caatagacaa     6480

cactgtatat cagctaagca aagttgaggg tgaacagcat gttataaaag gcagaccagt     6540

gtcaagcagc tttgatccag tcaagtttcc tgaagatcaa ttcaatgttg cacttgacca     6600

agtttttgag aacattgaaa acagccaggc cttggtggat caatcaaaca ggatcctaag     6660

cagtgcagag aaagggaaca ctatcatgat aactactata attatagtga ttatagtaat     6720

attgttatca ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccagt     6780

cacactaagc aaggatcaac tgagtggtat aaataatatt gcatttagta actgaataaa     6840

aatagcacct aatcatgttc ttacaatggt ttactatctg ctcatagaca acccatctat     6900

cattggattt tcttaaaatc tgaacttcat cgaaactctt atctataaac catctcactt     6960

acactattta agtagattcc tagtttatag ttatataaaa acacaattga atgccagtcg     7020

accttaccat ctgtaaaaat gaaaactggg gcaaatatgt cacgaaggaa tccttgcaaa     7080

tttgaaattc gaggtcattg cttaaatggt aagaggtgtc attttagtca taattatttt     7140

gaatggccac cccatgcact gcttgtaaga caaaacttta tgttaaacag aatacttaag     7200

tctatggata aaagtataga taccttatca gaaataagtg gagctgcaga gttggacaga     7260

acagaagagt atgctcttgg tgtagttgga gtgctagaga gttatatagg atcaataaac     7320

aatataacta aacaatcagc atgtgttgcc atgagcaaac tcctcactga actcaatagt     7380

gatgatatca aaaagctgag ggacaatgaa gagctaaatt cacccaagat aagagtgtac     7440

aatactgtca tatcatatat tgaaagcaac aggaaaaaca ataaacaaac tatccatctg     7500

ttaaaaagat tgccagcaga cgtattgaag aaaaccatca aaaacacatt ggatatccat     7560

aagagcataa ccatcaacaa cccaaaagaa tcaactgtta gtgatacaaa tgaccatgcc     7620

aaaaataatg atactacctg acaaatatcc ttgtagtata acttccatac taataacaag     7680

tagatgtaga gttactatgt ataatcaaaa gaacacacta tatttcaatc aaaacaaccc     7740

aaataaccat atgtactcac cgaatcaaac attcaatgaa atccattgga cctctcaaga     7800

attgattgac acaattcaaa attttctaca acatctaggt attattgagg atatatatac     7860

aatatatata ttagtgtcat aacactcaat tctaacactc accacatcgt tacattatta     7920

attcaaacaa ttcaagttgt gggacaaaat ggatcccatt attaatggaa attctgctaa     7980

tgtttatcta accgatagtt atttaaaagg tgttatctct ttctcagagt gtaatgcttt     8040

aggaagttac atattcaatg gtccttatct caaaaatgat tataccaact taattagtag     8100

acaaaatcca ttaatagaac acatgaatct aaagaaacta aatataacac agtccttaat     8160

atctaagtat cataaaggtg aaataaaatt agaagaacct acttattttc agtcattact     8220

tatgacatac aagagtatga cctcgtcaga acagattgct accactaatt tacttaaaaa     8280

gataataaga agagctatag aaataagtga tgtcaaagtc tatgctatat tgaataaact     8340

agggcttaaa gaaaaggaca agattaaatc caacaatgga caagatgaag acaactcagt     8400

tattacgacc ataatcaaag atgatatact ttcagctgtt aaagataatc aatctcatct     8460

taaagcagac aaaaatcact ctacaaaaca aaaagacaca atcaaaacaa cactcttgaa     8520

gaaattgatg tgttcaatgc aacatcctcc atcatggtta atacattggt ttaacttata     8580

cacaaaatta aacaacatat taacacagta tcgatcaaat gaggtaaaaa accatgggtt     8640

tacattgata gataatcaaa ctcttagtgg atttcaattt attttgaacc aatatggttg     8700

tatagtttat cataaggaac tcaaaagaat tactgtgaca acctataatc aattcttgac     8760

atggaaagat attagcctta gtagattaaa tgtttgttta attacatgga ttagtaactg     8820

cttgaacaca ttaaataaaa gcttaggctt aagatgcgga ttcaataatg ttatcttgac     8880

acaactattc ctttatggag attgtatact aaagctattt cacaatgagg ggttctacat     8940

aataaaagag gtagagggat ttattatgtc tctaatttta aatataacag aagaagatca     9000

attcagaaaa cgattttata atagtatgct caacaacatc acagatgctg ctaataaagc     9060

tcagaaaaat ctgctatcaa gagtatgtca tacattatta gataagacag tgtccgataa     9120

tataataaat ggcagatgga taattctatt aagtaagttc cttaaattaa ttaagcttgc     9180

aggtgacaat aaccttaaca atctgagtga actatatttt ttgttcagaa tatttggaca     9240

cccaatggta gatgaaagac aagccatgga tgctgttaaa attaattgca atgagaccaa     9300

attttacttg ttaagcagtc tgagtatgtt aagaggtgcc tttatatata gaattataaa     9360

agggtttgta aataattaca acagatggcc tactttaaga aatgctattg ttttaccctt     9420

aagatggtta acttactata aactaaacac ttatccttct ttgttggaac ttacagaaag     9480

agatttgatt gtgttatcag gactacgttt ctatcgtgag tttcggttgc ctaaaaaagt     9540

ggatcttgaa atgattataa atgataaagc tatatcacct cctaaaaatt tgatatggac     9600

tagtttccct agaaattaca tgccatcaca catacaaaac tatatagaac atgaaaaatt     9660

aaaattttcc gagagtgata aatcaagaag agtattagag tattatttaa gagataacaa     9720

attcaatgaa tgtgatttat acaactgtgt agttaatcaa agttatctca acaaccctaa     9780

tcatgtggta tcattgacag gcaaagaaag agaactcagt gtaggtagaa tgtttgcaat     9840

gcaaccggga atgttcagac aggttcaaat attggcagag aaaatgatag ctgaaaacat     9900

tttacaattc tttcctgaaa gtcttacaag atatggtgat ctagaactac aaaaaatatt     9960

agaattgaaa gcaggaataa gtaacaaatc aaatcgctac aatgataatt acaacaatta    10020

cattagtaag tgctctatca tcacagatct cagcaaattc aatcaagcat ttcgatatga    10080

aacgtcatgt atttgtagtg atgtgctgga tgaactgcat ggtgtacaat ctctattttc    10140

ctggttacat ttaactattc ctcatgtcac aataatatgc acatataggc atgcaccccc    10200

ctatatagga gatcatattg tagatcttaa caatgtagat gaacaaagtg gattatatag    10260

atatcacatg ggtggcatcg aagggtggtg tcaaaaactg tggaccatag aagctatatc    10320

actattggat ctaatatctc tcaaagggaa attctcaatt actgctttaa ttaatggtga    10380

caatcaatca atagatataa gcaaaccaat cagactcatg gaaggtcaaa ctcatgctca    10440

agcagattat ttgctagcat taaatagcct taaattactg tataaagagt atgcaggcat    10500

aggccacaaa ttaaaaggaa ctgagactta tatatcacga gatatgcaat ttatgagtaa    10560

aacaattcaa cataacggtg tatattaccc agctagtata aagaaagtcc taagagtggg    10620

accgtggata aacactatac ttgatgattt caaagtgagt ctagaatcta taggtagttt    10680

gacacaagaa ttagaatata gaggtgaaag tctattatgc agtttaatat ttagaaatgt    10740

atggttatat aatcagattg ctctacaatt aaaaaatcat gcattatgta acaataaact    10800

atatttggac atattaaagg ttctgaaaca cttaaaaacc ttttttaatc ttgataatat    10860

tgatacagca ttaacattgt atatgaattt acccatgtta tttggtggtg gtgatcccaa    10920

cttgttatat cgaagtttct atagaagaac tcctgacttc ctcacagagg ctatagttca    10980

ctctgtgttc atacttagtt attatacaaa ccatgactta aaagataaac ttcaagatct    11040

gtcagatgat agattgaata agttcttaac atgcataatc acgtttgaca aaaaccctaa    11100

tgctgaattc gtaacattga tgagagatcc tcaagcttta gggtctgaga gacaagctaa    11160

aattactagc gaaatcaata gactggcagt tacagaggtt ttgagtacag ctccaaacaa    11220

aatattctcc aaaagtgcac aacattatac tactacagag atagatctaa atgatattat    11280

gcaaaatata gaacctacat atcctcatgg gctaagagtt gtttatgaaa gtttaccctt    11340

ttataaagca gagaaaatag taaatcttat atcaggtaca aaatctataa ctaacatact    11400

ggaaaaaact tctgccatag acttaacaga tattgataga gccactgaga tgatgaggaa    11460

aaacataact ttgcttataa ggatacttcc attggattgt aacagagata aaagagagat    11520

attgagtatg gaaaacctaa gtattactga attaagcaaa tatgttaggg aaagatcttg    11580

gtctttatcc aatatagttg gtgttacatc acccagtatc atgtatacaa tggacatcaa    11640

atatactaca agcactatat ctagtggcat aattatagag aaatataatg ttaacagttt    11700

aacacgtggt gagagaggac ccactaaacc atgggttggt tcatctacac aagagaaaaa    11760

aacaatgcca gtttataata gacaagtctt aaccaaaaaa cagagagatc aaatagatct    11820

attagcaaaa ttggattggg tgtatgcatc tatagataac aaggatgaat tcatggaaga    11880

actcagcata ggaacccttg ggttaacata tgaaaaggcc aagaaattat ttccacaata    11940

tttaagtgtc aattatttgc atcgccttac agtcagtagt agaccatgtg aattccctgc    12000

atcaatacca gcttatagaa caacaaatta tcactttgac actagcccta ttaatcgcat    12060

attaacagaa aagtatggtg atgaagatat tgacatagta ttccaaaact gtataagctt    12120

tggccttagt ttaatgtcag tagtagaaca atttactaat gtatgtccta acagaattat    12180

tctcatacct aagcttaatg agatacattt gatgaaacct cccatattca caggtgatgt    12240

tgatattcac aagttaaaac aagtgataca aaaacagcat atgtttttac cagacaaaat    12300

aagtttgact caatatgtgg aattattctt aagtaataaa acactcaaat ctggatctca    12360

tgttaattct aatttaatat tggcacataa aatatctgac tattttcata atacttacat    12420

tttaagtact aatttagctg gacattggat tctgattata caacttatga aagattctaa    12480

aggtattttt gaaaaagatt ggggagaggg atatataact gatcatatgt ttattaattt    12540

gaaagttttc ttcaatgctt ataagaccta tctcttgtgt tttcataaag gttatggcaa    12600

agcaaagctg gagtgtgata tgaacacttc agatcttcta tgtgtattgg aattaataga    12660

cagtagttat tggaagtcta tgtctaaggt atttttagaa caaaaagtta tcaaatacat    12720

tcttagccaa gatgcaagtt tacatagagt aaaaggatgt catagcttca aattatggtt    12780

tcttaaacgt cttaatgtag cagaattcac agtttgccct tgggttgtta acatagatta    12840

tcatccaaca catatgaaag caatattaac ttatatagat cttgttagaa tgggattgat    12900

aaatatagat agaatacaca ttaaaaataa acacaaattc aatgatgaat tttatacttc    12960

taatctcttc tacattaatt ataacttctc agataatact catctattaa ctaaacatat    13020

aaggattgct aattctgaat tagaaaataa ttacaacaaa ttatatcatc ctacaccaga    13080

aaccctagag aatatactag ccaatccgat taaaagtaat gacaaaaaga cactgaatga    13140

ctattgtata ggtaaaaatg ttgactcaat aatgttacca ttgttatcta ataagaagct    13200

tattaaatcg tctgcaatga ttagaaccaa ttacagcaaa caagatttgt ataatttatt    13260

ccctatggtt gtgattgata gaattataga tcattcaggc aatacagcca aatccaacca    13320

actttacact actacttccc accaaatatc tttagtgcac aatagcacat cactttactg    13380

catgcttcct tggcatcata ttaatagatt caattttgta tttagttcta caggttgtaa    13440

aattagtata gagtatattt taaaagatct taaaattaaa gatcccaatt gtatagcatt    13500

cataggtgaa ggagcaggga atttattatt gcgtacagta gtggaacttc atcctgacat    13560

aagatatatt tacagaagtc tgaaagattg caatgatcat agtttaccta ttgagttttt    13620

aaggctgtac aatggacata tcaacattga ttatggtgaa aatttgacca ttcctgctac    13680

agatgcaacc aacaacattc attggtctta tttacatata aagtttgctg aacctatcag    13740

tctttttgtc tgtgatgccg aattgtctgt aacagtcaac tggagtaaaa ttataataga    13800

atggagcaag catgtaagaa agtgcaagta ctgttcctca gttaataaat gtatgttaat    13860

agtaaaatat catgctcaag atgatattga tttcaaatta gacaatataa ctatattaaa    13920

aacttatgta tgcttaggca gtaagttaaa gggatcggag gtttacttag tccttacaat    13980

aggtcctgcg aatatattcc cagtatttaa tgtagtacaa aatgctaaat tgatactatc    14040

aagaaccaaa aatttcatca tgcctaagaa agctgataaa gagtctattg atgcaaatat    14100

taaaagtttg ataccctttc tttgttaccc tataacaaaa aaaggaatta atactgcatt    14160

gtcaaaacta aagagtgttg ttagtggaga tatactatca tattctatag ctggacgtaa    14220

tgaagttttc agcaataaac ttataaatca taagcatatg aacatcttaa aatggttcaa    14280

tcatgtttta aatttcagat caacagaact aaactataac catttatata tggtagaatc    14340

tacatatcct tacctaagtg aattgttaaa cagcttgaca accaatgaac ttaaaaaact    14400

gattaaaatc acaggtagtc tgttatacaa ctttcataat gaataatgaa taaagatctt    14460

ataataaaaa ttcccatagc tatacactaa cactgtattc aattatagtt attaaaaatt    14520

aaaaatcgta cgatttttta aataactttt agtgaactaa tcctaaagtt atcattttaa    14580

tcttggagga ataaatttaa accctaatct aattggttta tatgtgtatt aactaaatta    14640

cgagatatta gtttttgaca ctttttttct cgtgggtcgg catggcatct ccacctcctc    14700

gcggtccgac ctgggcatcc gaaggaggac gcacgtccac tcggatggct aagggagctg    14760

ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactagcat    14820

aaccccttgg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat    14880


