                         SEQUENCE LISTING

<110>  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
 
<120>  Cortistatin or an analogue thereof as a pharmaceutically active 
       agent in latent form

<130>  904 935

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Precursor domain of TGFBeta


<220>
<221>  PEPTIDE
<222>  (1)..(273)

<400>  1

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser 
    


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteolytic cleavage site


<220>
<221>  PEPTIDE
<222>  (1)..(6)

<400>  2

Pro Leu Gly Leu Trp Ala 
1               5       


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide


<220>
<221>  PEPTIDE
<222>  (1)..(5)

<400>  3

Gly Gly Gly Gly Ser 
1               5   


<210>  4
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion peptide


<220>
<221>  PEPTIDE
<222>  (1)..(321)

<220>
<221>  PEPTIDE
<222>  (1)..(323)

<400>  4

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Glu Phe Gly Gly Gly Gly Ser Pro Leu Gly Leu Trp Ala Gly Gly 
        275                 280                 285             


Gly Gly Ser Ala Ala Ala Gln Glu Arg Pro Pro Leu Gln Gln Pro Pro 
    290                 295                 300                 


His Arg Asp Lys Lys Pro Cys Lys Asn Phe Phe Trp Lys Thr Phe Ser 
305                 310                 315                 320 


Ser Cys Lys 
            


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker region


<220>
<221>  PEPTIDE
<222>  (1)..(8)

<400>  5

Gly Gly Gly Gly Ser Ala Ala Ala 
1               5               


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST-29


<220>
<221>  PEPTIDE
<222>  (1)..(14)

<400>  6

Pro Cys Lys Asn Phe Phe Trp Lys Thr Phe Ser Ser Cys Lys 
1               5                   10                  


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST 17


<220>
<221>  PEPTIDE
<222>  (1)..(17)

<400>  7

Asp Arg Met Pro Cys Arg Asn Phe Phe Trp Lys Thr Phe Ser Ser Cys 
1               5                   10                  15      


Lys 
    


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin 14


<220>
<221>  PEPTIDE
<222>  (1)..(14)

<400>  8

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  3,5-difluorophenylalanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  3,5-difluorofenilalanina

<400>  9

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  3,5-difluorophenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  3,5-difluorofenilalanina

<400>  10

Ala Gly Cys Lys Asn Xaa Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  3,5-difluorophenylalanine

<400>  11

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Xaa Thr Ser Cys 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  3,5-difluorofenilalanina

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  3,5-difluorofenilalanina

<400>  12

Ala Gly Cys Arg Asn Xaa Phe Trp Lys Thr Xaa Ser Ser Cys 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  3,4,5-trimetilfenilalanina

<400>  13

Pro Cys Lys Asn Xaa Phe Trp Lys Thr Phe Thr Ser Cys Lys 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  3,4,5-trimetilfenilalanina

<400>  14

Pro Cys Lys Asn Phe Xaa Trp Lys Thr Phe Thr Ser Cys Lys 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  3,5-difluorofenilalanina

<400>  15

Pro Cys Lys Asn Phe Xaa Trp Lys Thr Phe Thr Ser Cys Lys 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3,4,5-trimetilfenilalanina

<400>  16

Pro Cys Lys Asn Phe Phe Trp Lys Thr Xaa Thr Ser Cys Lys 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  3,4,5-trimetilfenilalanina

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3,4,5-trimetilfenilalanina

<400>  17

Pro Cys Arg Asn Xaa Phe Trp Lys Thr Xaa Thr Ser Cys Lys 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  3,5-difluorofenilalanina

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3,4,5-trimetilfenilalanina

<400>  18

Pro Cys Lys Asn Xaa Phe Trp Lys Thr Xaa Ser Ser Cys Lys 
1               5                   10                  


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  3,4,5-trimetilfenilalanina

<400>  19

Pro Cys Lys Asn Xaa Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3,5-difluorofenilalanina

<400>  20

Pro Cys Lys Asn Phe Phe Trp Lys Thr Xaa Thr Ser Cys 
1               5                   10              


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  3,4,5-trimetilfenilalanina

<400>  21

Met Pro Cys Arg Asn Xaa Phe Trp Lys Thr Phe Ser Ser Cys Lys 
1               5                   10                  15  


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  3,4,5-trimetilfenilalanina

<400>  22

Asp Arg Met Pro Cys Arg Asn Xaa Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  15      


Lys 
    


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  3,5-difluorofenilalanina

<400>  23

Asn Arg Met Pro Cys Arg Asn Xaa Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  15      


Lys 
    


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  3,4,5-trimetilfenilalanina

<400>  24

Pro Cys Lys Asn Phe Xaa Trp Lys Thr Phe Thr Ser Cys Lys 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  3,4,5-trimetilfenilalanina

<400>  25

Pro Cys Lys Asn Phe Xaa Trp Lys Thr Phe Thr Ser Cys Lys 
1               5                   10                  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  3,5-difluorofenilalanina

<400>  26

Pro Cys Lys Asn Phe Xaa Trp Lys Thr Phe Thr Ser Cys Lys 
1               5                   10                  


<210>  27
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3,4,5-trimetilfenilalanina

<400>  27

Pro Cys Lys Asn Phe Phe Trp Lys Thr Xaa Thr Ser Cys Lys 
1               5                   10                  


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  3,4,5-trimetilfenilalanina

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Pro Cys Arg Asn Xaa Phe Trp Lys Thr Xaa Thr Ser Cys Lys 
1               5                   10                  


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  3,5-difluorofenilalanina

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Pro Cys Lys Asn Xaa Phe Trp Lys Thr Xaa Ser Ser Cys Lys 
1               5                   10                  


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  3,4,5-trimetilfenilalanina

<400>  30

Pro Cys Lys Asn Xaa Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  3,4,5-trimetilfenilalanina

<400>  31

Pro Cys Lys Asn Xaa Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3,5-difluorofenilalanina

<400>  32

Pro Cys Lys Asn Phe Phe Trp Lys Thr Xaa Thr Ser Cys 
1               5                   10              


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  3,4,5-trimetilfenilalanina

<400>  33

Met Pro Cys Arg Asn Xaa Phe Trp Lys Thr Phe Ser Ser Cys Lys 
1               5                   10                  15  


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  3,4,5-trimetilfenilalanina

<400>  34

Asp Arg Met Pro Cys Arg Asn Xaa Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  15      


Lys 
    


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  3,4,5-trimetilfenilalanina

<400>  35

Asp Arg Met Pro Cys Arg Asn Xaa Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  15      


Lys 
    


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST analogue


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  3,4,5-trimetilfenilalanina

<400>  36

Asp Arg Met Pro Cys Arg Asn Xaa Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  15      


Lys 
    


