                         SEQUENCE LISTING

<110>  ABERA BIOSCIENCE AB
 
<120>  DECORATED INCLUSION BODY AND USES THEREOF

<130>  21111860

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  256
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  1

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ser Ala Thr 
1               5                   10                  15      


His Ile Lys Phe Ser Lys Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly 
            20                  25                  30          


Ala Thr Met Glu Leu Arg Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp 
        35                  40                  45              


Ile Ser Asp Gly Gln Val Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr 
    50                  55                  60                  


Thr Phe Val Glu Thr Ala Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala 
65                  70                  75                  80  


Ile Thr Phe Thr Val Asn Glu Gln Gly Gln Val Thr Val Asn Gly Lys 
                85                  90                  95      


Ala Thr Lys Gly Asp Ala His Ile Gly Ser Pro Ala Asn Leu Lys Ala 
            100                 105                 110         


Leu Glu Ala Gln Lys Gln Lys Glu Gln Arg Gln Ala Ala Glu Glu Leu 
        115                 120                 125             


Ala Asn Ala Lys Lys Leu Lys Glu Gln Leu Glu Lys Gly Ser His Met 
    130                 135                 140                 


Lys Pro Leu Arg Gly Ala Val Phe Ser Leu Gln Lys Gln His Pro Asp 
145                 150                 155                 160 


Tyr Pro Asp Ile Tyr Gly Ala Ile Asp Gln Asn Gly Thr Tyr Gln Asn 
                165                 170                 175     


Val Arg Thr Gly Glu Asp Gly Lys Leu Thr Phe Lys Asn Leu Ser Asp 
            180                 185                 190         


Gly Lys Tyr Arg Leu Phe Glu Asn Ser Glu Pro Ala Gly Tyr Lys Pro 
        195                 200                 205             


Val Gln Asn Lys Pro Ile Val Ala Phe Gln Ile Val Asn Gly Glu Val 
    210                 215                 220                 


Arg Asp Val Thr Ser Ile Val Pro Gln Asp Ile Pro Ala Thr Tyr Glu 
225                 230                 235                 240 


Phe Thr Asn Gly Lys His Tyr Ile Thr Asn Glu Pro Ile Pro Pro Lys 
                245                 250                 255     


<210>  2
<211>  504
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  2

Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Ser Met Asn Asn Asn Asp Leu Phe Gln Ala Ser 
        35                  40                  45              


Arg Arg Arg Phe Leu Ala Gln Leu Gly Gly Leu Thr Val Ala Gly Met 
    50                  55                  60                  


Leu Gly Pro Ser Leu Leu Thr Pro Arg Arg Ala Ser Met Asn Asn Asn 
65                  70                  75                  80  


Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala Gln Leu Gly Gly 
                85                  90                  95      


Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu Thr Pro Arg Arg 
            100                 105                 110         


Ala Ser Ala Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly 
        115                 120                 125             


Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys 
    130                 135                 140                 


Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu 
145                 150                 155                 160 


Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe 
                165                 170                 175     


Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala 
            180                 185                 190         


Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr 
        195                 200                 205             


Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala 
    210                 215                 220                 


Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro 
225                 230                 235                 240 


Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala 
                245                 250                 255     


Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr 
            260                 265                 270         


Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn 
        275                 280                 285             


Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys 
    290                 295                 300                 


Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn 
305                 310                 315                 320 


Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu 
                325                 330                 335     


Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr 
            340                 345                 350         


Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln 
        355                 360                 365             


Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala 
    370                 375                 380                 


Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu 
385                 390                 395                 400 


Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala 
                405                 410                 415     


Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile 
            420                 425                 430         


Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile 
        435                 440                 445             


Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn 
    450                 455                 460                 


Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln 
465                 470                 475                 480 


Thr Arg Ile Thr Lys Gly Ser Gly Ser Gly Ser Ala His Ile Val Met 
                485                 490                 495     


Val Asp Ala Tyr Lys Pro Thr Lys 
            500                 


<210>  3
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  3

Met Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val Thr Gly Lys 
1               5                   10                  15      


Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys Gly Trp Gly 
            20                  25                  30          


Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Cys Cys Trp Ala His 
        35                  40                  45              


Asp His Cys Tyr Gly Arg Leu Glu Glu Lys Gly Cys Asn Ile Arg Thr 
    50                  55                  60                  


Gln Ser Tyr Lys Tyr Arg Phe Ala Trp Gly Val Val Thr Cys Glu Pro 
65                  70                  75                  80  


Gly Pro Phe Cys His Val Asn Leu Cys Ala Cys Asp Arg Lys Leu Val 
                85                  90                  95      


Tyr Cys Leu Lys Arg Asn Leu Arg Ser Tyr Asn Pro Gln Tyr Gln Tyr 
            100                 105                 110         


Phe Pro Asn Ile Leu Cys Ser Gly Thr Gly Ser Gly Ser Lys Leu Gly 
        115                 120                 125             


Asp Ile Glu Phe Ile Lys Val Asn Lys 
    130                 135         


<210>  4
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  4

Met Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val Thr Gly Lys 
1               5                   10                  15      


Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys Gly Trp Gly 
            20                  25                  30          


Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Cys Cys Trp Ala His 
        35                  40                  45              


Asp His Cys Tyr Gly Arg Leu Glu Glu Lys Gly Cys Asn Ile Arg Thr 
    50                  55                  60                  


Gln Ser Tyr Lys Tyr Arg Phe Ala Trp Gly Val Val Thr Cys Glu Pro 
65                  70                  75                  80  


Gly Pro Phe Cys His Val Asn Leu Cys Ala Cys Asp Arg Lys Leu Val 
                85                  90                  95      


Tyr Cys Leu Lys Arg Asn Leu Arg Ser Tyr Asn Pro Gln Tyr Gln Tyr 
            100                 105                 110         


Phe Pro Asn Ile Leu Cys Ser Gly Thr Gly Ser Gly Ser Ala His Ile 
        115                 120                 125             


Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
    130                 135             


<210>  5
<211>  503
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  5

Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Ser Met Asn Asn Asn Asp Leu Phe Gln Ala Ser 
        35                  40                  45              


Arg Arg Arg Phe Leu Ala Gln Leu Gly Gly Leu Thr Val Ala Gly Met 
    50                  55                  60                  


Leu Gly Pro Ser Leu Leu Thr Pro Arg Arg Ala Ser Met Asn Asn Asn 
65                  70                  75                  80  


Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala Gln Leu Gly Gly 
                85                  90                  95      


Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu Thr Pro Arg Arg 
            100                 105                 110         


Ala Ser Ala Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly 
        115                 120                 125             


Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys 
    130                 135                 140                 


Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu 
145                 150                 155                 160 


Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe 
                165                 170                 175     


Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala 
            180                 185                 190         


Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr 
        195                 200                 205             


Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala 
    210                 215                 220                 


Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro 
225                 230                 235                 240 


Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala 
                245                 250                 255     


Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr 
            260                 265                 270         


Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn 
        275                 280                 285             


Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys 
    290                 295                 300                 


Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn 
305                 310                 315                 320 


Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu 
                325                 330                 335     


Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr 
            340                 345                 350         


Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln 
        355                 360                 365             


Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala 
    370                 375                 380                 


Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu 
385                 390                 395                 400 


Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala 
                405                 410                 415     


Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile 
            420                 425                 430         


Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile 
        435                 440                 445             


Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn 
    450                 455                 460                 


Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln 
465                 470                 475                 480 


Thr Arg Ile Thr Lys Gly Ser Gly Ser Gly Ser Ala Thr His Ile Lys 
                485                 490                 495     


Phe Ser Lys Arg Asp Gly Tyr 
            500             


<210>  6
<211>  108
<212>  PRT
<213>  Streptococcus pyogenes

<400>  6

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Gly Gln Ser 
1               5                   10                  15      


Gly Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser 
            20                  25                  30          


Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys Asp 
        35                  40                  45              


Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro 
    50                  55                  60                  


Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln 
65                  70                  75                  80  


Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Gly Ser Gly Gly 
                85                  90                  95      


Ser Gly Gly Ser Gly Glu Asp Ser Ala Thr His Ile 
            100                 105             


<210>  7
<211>  305
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  7

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gly Lys Leu Gly Asp Ile Glu Phe Ile Lys Val 
            20                  25                  30          


Asn Lys Gly Ser Gly Glu Ser Gly Ser Gly Val Ser Lys Gly Glu Glu 
        35                  40                  45              


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    50                  55                  60                  


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
65                  70                  75                  80  


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
                85                  90                  95      


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys 
            100                 105                 110         


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        115                 120                 125             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    130                 135                 140                 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
145                 150                 155                 160 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                165                 170                 175     


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
            180                 185                 190         


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
        195                 200                 205             


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
    210                 215                 220                 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
225                 230                 235                 240 


His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys 
                245                 250                 255     


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
            260                 265                 270         


Leu Gly Met Asp Glu Leu Tyr Lys Gly Ser Gly Glu Gly Ser Gly Ser 
        275                 280                 285             


Gly Ser Gly Ser Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr 
    290                 295                 300                 


Lys 
305 


<210>  8
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  8

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Met Val Gln Leu Val Glu Ser Gly Gly Ala 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser 
65                  70                  75                  80  


Ser Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
                85                  90                  95      


Ala Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Gln Val Thr Val Ser Ser Lys Gly Ser Gly Gly Thr Gly 
    130                 135                 140                 


Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp Glu Asp Gly Lys 
145                 150                 155                 160 


Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser Ser Gly Lys Thr 
                165                 170                 175     


Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys Asp Phe Tyr Leu Tyr 
            180                 185                 190         


Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro Asp Gly Tyr Glu 
        195                 200                 205             


Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln Gly Gln Val Thr 
    210                 215                 220                 


Val Asn Gly Lys Ala Thr Lys Gly Asp Ala His Ile Gly Ser Gly His 
225                 230                 235                 240 


His His His His His 
                245 


<210>  9
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  9

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Met Val Gln Leu Val Glu Ser Gly Gly Ala 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser 
65                  70                  75                  80  


Ser Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
                85                  90                  95      


Ala Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Gln Val Thr Val Ser Ser Lys Gly Ser Gly Gly Thr Gly 
    130                 135                 140                 


Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp Glu Asp Gly Lys 
145                 150                 155                 160 


Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser Ser Gly Lys Thr 
                165                 170                 175     


Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys Asp Phe Tyr Leu Tyr 
            180                 185                 190         


Pro Gly Lys Tyr Thr Phe Val Gln Thr Ala Ala Pro Asp Gly Tyr Glu 
        195                 200                 205             


Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln Gly Gln Val Thr 
    210                 215                 220                 


Val Asn Gly Lys Ala Thr Lys Gly Asp Ala His Ile Gly Ser Gly His 
225                 230                 235                 240 


His His His His His 
                245 


<210>  10
<211>  251
<212>  PRT
<213>  Aequorea victoria

<400>  10

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Lys Leu 
225                 230                 235                 240 


Ala Ala Ala Leu Glu His His His His His His 
                245                 250     


<210>  11
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  11

Met Gly Lys Gly Ser Gly Ser Val Asp Asn Lys Phe Asn Lys Glu Gln 
1               5                   10                  15      


Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu 
            20                  25                  30          


Gln Arg Asn Ala Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser 
        35                  40                  45              


Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro 
    50                  55                  60                  


Lys Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
65                  70                  75                  80  


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile 
                85                  90                  95      


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
            100                 105                 110         


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Gly Ser Val Thr Thr 
        115                 120                 125             


Leu Ser Gly Leu Ser Gly Glu Gln Gly Pro Ser Gly Asp Met Thr Thr 
    130                 135                 140                 


Glu Glu Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp Glu Asp 
145                 150                 155                 160 


Gly Arg Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser Ser Gly 
                165                 170                 175     


Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly His Val Lys Asp Phe Tyr 
            180                 185                 190         


Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro Asp Gly 
        195                 200                 205             


Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln Gly Gln 
    210                 215                 220                 


Val Thr Val Asn Gly Glu Ala Thr Lys Gly Asp Ala His Thr Gly Ser 
225                 230                 235                 240 


Ser Gly Ser Leu Glu His His His His His His 
                245                 250     


<210>  12
<211>  642
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  12

Met Gly Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
1               5                   10                  15      


Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
            20                  25                  30          


Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
        35                  40                  45              


Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
    50                  55                  60                  


Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
65                  70                  75                  80  


Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser 
                85                  90                  95      


Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
            100                 105                 110         


Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
        115                 120                 125             


Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
    130                 135                 140                 


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
145                 150                 155                 160 


Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln 
                165                 170                 175     


Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
            180                 185                 190         


Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
        195                 200                 205             


Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu 
    210                 215                 220                 


Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn 
225                 230                 235                 240 


Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu 
                245                 250                 255     


Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
            260                 265                 270         


Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu 
        275                 280                 285             


Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Ser Leu Glu Gly Ser Gly 
    290                 295                 300                 


Ser Gly Thr Tyr Lys Leu Ile Leu Asn Gly Lys Thr Leu Lys Gly Glu 
305                 310                 315                 320 


Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys 
                325                 330                 335     


Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp 
            340                 345                 350         


Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val Ile Asp Ala 
        355                 360                 365             


Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly 
    370                 375                 380                 


Lys Thr Leu Lys Gly Glu Thr Thr Thr Glu Ala Val Asp Ala Ala Thr 
385                 390                 395                 400 


Ala Glu Lys Val Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly 
                405                 410                 415     


Glu Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Lys 
            420                 425                 430         


Pro Glu Val Ile Asp Ala Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr 
        435                 440                 445             


Lys Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr Thr Lys 
    450                 455                 460                 


Ala Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln Tyr Ala Asn 
465                 470                 475                 480 


Asp Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp Ala Thr Lys Thr 
                485                 490                 495     


Phe Thr Val Thr Glu Lys Leu Ala Ala Ala Gly Thr Gly Ser Gly Glu 
            500                 505                 510         


Gly Ser Gly Ser Val Thr Thr Leu Ser Gly Leu Ser Gly Glu Gln Gly 
        515                 520                 525             


Pro Ser Gly Asp Met Thr Thr Glu Glu Asp Ser Ala Thr His Ile Lys 
    530                 535                 540                 


Phe Ser Lys Arg Asp Glu Asp Gly Arg Glu Leu Ala Gly Ala Thr Met 
545                 550                 555                 560 


Glu Leu Arg Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp 
                565                 570                 575     


Gly His Val Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val 
            580                 585                 590         


Glu Thr Ala Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe 
        595                 600                 605             


Thr Val Asn Glu Gln Gly Gln Val Thr Val Asn Gly Glu Ala Thr Lys 
    610                 615                 620                 


Gly Asp Ala His Thr Gly Ser Ser Gly Ser Leu Glu His His His His 
625                 630                 635                 640 


His His 
        


<210>  13
<211>  503
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered fusion protein

<400>  13

Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Ser Met Asn Asn Asn Asp Leu Phe Gln Ala Ser 
        35                  40                  45              


Arg Arg Arg Phe Leu Ala Gln Leu Gly Gly Leu Thr Val Ala Gly Met 
    50                  55                  60                  


Leu Gly Pro Ser Leu Leu Thr Pro Arg Arg Ala Ser Met Asn Asn Asn 
65                  70                  75                  80  


Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala Gln Leu Gly Gly 
                85                  90                  95      


Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu Thr Pro Arg Arg 
            100                 105                 110         


Ala Ser Ala Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly 
        115                 120                 125             


Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys 
    130                 135                 140                 


Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu 
145                 150                 155                 160 


Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe 
                165                 170                 175     


Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala 
            180                 185                 190         


Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr 
        195                 200                 205             


Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala 
    210                 215                 220                 


Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro 
225                 230                 235                 240 


Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala 
                245                 250                 255     


Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr 
            260                 265                 270         


Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn 
        275                 280                 285             


Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys 
    290                 295                 300                 


Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn 
305                 310                 315                 320 


Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu 
                325                 330                 335     


Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr 
            340                 345                 350         


Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln 
        355                 360                 365             


Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala 
    370                 375                 380                 


Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu 
385                 390                 395                 400 


Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala 
                405                 410                 415     


Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile 
            420                 425                 430         


Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile 
        435                 440                 445             


Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn 
    450                 455                 460                 


Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln 
465                 470                 475                 480 


Thr Arg Ile Thr Lys Gly Ser Gly Ser Gly Ser Lys Leu Gly Asp Ile 
                485                 490                 495     


Glu Phe Ile Lys Val Asn Lys 
            500             


