                         SEQUENCE LISTING

<110>  DuPont Nutrition Biosciences ApS
 
<120>  LACTIC ACID BACTERIUM WITH A REDUCTION OF SENSITIVITY TO COS-TYPE BACTERIOPHAGES

<130>  NB41O22-WO-PCT

<150>  US62805388
<151>  2019-02-14

<150>  US62904787
<151>  2019-09-24

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  861
<212>  DNA
<213>  Streptococcus thermophilus

<400>  1
atgattacac tgaaatcagc acgtgaaatt gaagcgatgg atagagcggg agattttctt       60

gcaagtatcc acattggcct acgtgatctc ttgaaaccag gagtggatat gtgggaagta      120

gaagagtatg ttcgtcgtcg ttgtaaagaa gaaaatgttc tgccacttca gattggggtt      180

gaaggaagca tcatggacta tccttatgcg acatgttgta gtcttaatga tgaagtagca      240

cacgcttttc cacgtcatta tattttgaaa gatggagacc tcttgaaagt tgatatggtc      300

ttgtcagaac ctattgataa gtcagtgctt gatgtatcaa aattggactt tgataatgtt      360

gcccaggtaa aaaaatatac agaatcatat gctggtggtt tggctgactc atgttgggca      420

tatgcgattg gaacgccttc tgatgaggtt aaaaacctta tggaagtaac ccgtgaagcc      480

atgtatcttg gtattgaaca agcgttagtt ggtaatcgta tcggtgatat cggtgcagct      540

atccaagaat acgctgaaag tcgaggctat ggtgtcgtac gtgatttggt cggacacgga      600

gttggaccaa caatgcatga agaaccaatg gttcctaact atggcgtggc tggacgtggt      660

cttcgcctta aagaaggaat ggtcttgacc atcgagccaa tgattaacac aggaacttgg      720

gaaatcgata cagaccttga aactggttgg gctcataaga cacttgacgg tggcctttca      780

tgccaatatg agcaccaatt tgtaattact aaagatggtc cagtaatttt gacttctcaa      840

ggggaagaaa gaacttatta a                                                861


<210>  2
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus

<400>  2

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  3
<211>  861
<212>  DNA
<213>  Streptococcus thermophilus

<400>  3
atgattacac tgaaatcagc acgtgaaatt gaagcgatgg atagagcggg agattttctt       60

gcaagtatcc acattggcct acgtgatctc ttgaaaccag gagtggatat gtgggaagta      120

gaagagtatg ttcgtcgtcg ttgtaaagaa gaaaatgttc tgccacttca gattggggtt      180

gaaggaagca tcatggacta tccttatgcg acatgttgta gtcttaatga tgaagtagca      240

cacgcttttc cacgtcatta tattttgaaa gatggagacc tcttgaaagt tgatatggtc      300

ttgtcagaac ctattgataa gtcagtgctt gatgtatcaa aattggactt tgataatgtt      360

gcccaggtaa aaaaatatac agaatcatat gctggtggtt tggctgactc atgttgggca      420

tatgcgattg gaacgccttc tgatgaggtt aaaaacctta tggaagtaac ccgtgaagcc      480

atgtatcttg gtattgaaca agcgttagtt ggtaatcgta tcggtgatat cggtgcagct      540

atccaagaat acgctgaaag tcgaggctat ggtgtcgtac gtgatttggt cggacacgga      600

gttggaccaa caatgcagga agaaccaatg gttcctaact atggcgtggc tggacgtggt      660

cttcgcctta aagaaggaat ggtcttgacc atcgagccaa tgattaacac aggaacttgg      720

gaaatcgata cagaccttga aactggttgg gctcataaga cacttgacgg tggcctttca      780

tgccaatatg agcaccaatt tgtaattact aaagatggtc cagtaatttt gacttctcaa      840

ggggaagaaa gaacttatta a                                                861


<210>  4
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus

<400>  4

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met Gln Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  5
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid, but not Gln

<400>  5

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Xaa Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  6
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (153)..(153)
<223>  Xaa can be any naturally occurring amino acid, but not Leu

<400>  6

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Xaa Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  7
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  Xaa can be any naturally occurring amino acid, but not Ala

<400>  7

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Xaa Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  8
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (206)..(206)
<223>  Xaa can be any naturally occurring amino acid, but not His

<400>  8

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met Xaa Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  9
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (228)..(228)
<223>  Xaa can be any naturally occurring amino acid, but not Val

<400>  9

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Xaa Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  10
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (233)..(233)
<223>  Xaa can be any naturally occurring amino acid, but not Pro

<400>  10

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Xaa Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  11
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus

<400>  11

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Lys Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  12
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus

<400>  12

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Pro Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  13
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus

<400>  13

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Glu Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  14
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus

<400>  14

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Asp Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  15
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus

<400>  15

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Gln Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  16
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus

<400>  16

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Leu Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Leu Glu Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Arg Thr Tyr 
        275                 280                 285     


<210>  17
<211>  225
<212>  PRT
<213>  Streptococcus thermophilus

<400>  17

Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Arg Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Leu Lys 
            20                  25                  30          


Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Val Leu Pro Leu Gln Ile Gly Val Glu Gly Ser Ile 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Ser Glu Pro Ile Asp Lys Ser Val Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asp Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Glu 
        115                 120                 125             


Ser Tyr Ala Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Ile Gly 
    130                 135                 140                 


Thr Pro Ser Asp Glu Val Lys Asn Leu Met Glu Val Thr Arg Glu Ala 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Glu Gln Ala Leu Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Met Val Pro Asn Tyr Gly Val Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu 
225 


<210>  18
<211>  861
<212>  DNA
<213>  Streptococcus mutans

<400>  18
atgattacgt taaaatcaca gcgtgaaatt gaagcgatgg atgaggcagg tgattttctg       60

gctagcattc atatcggttt gcgtgatttg attaaacccg gacttgatat gtggaaaatt      120

gaagaatatg ttcgcagacg ttgtaaggaa gagaactatc ttcccttaca aattggtgtt      180

gatgggcagc ttatggatta cccctacgca acttgctgcg gactcaatga tgaagttgca      240

cacgcctttc cacgtcatta tatcttgaaa gatggcgatc ttcttaaagt tgatatggta      300

cttggcggtc ccattgctaa agaagaccta gatgtctcaa aattgaattt tgacaatgtg      360

gctcaagtca aaaaatatac agatagtttt cgtggcggtg tggctgattc ctgctgggcc      420

tatgccgttg gcgatgtttc tcaagaagta aagaatctaa tggcagtgac taaagagtgt      480

ctctatcgtg gaattgaaaa ggcagtagtt ggcaatcgta ttggtgacat tggagcagct      540

attcaagaat atgctgaggc caacggttat ggtgtcgtcc gtgatttagt tggtcatggt      600

gttggcccaa ccatgcatga agaacccaat gtaccgcatt atggcagagc aggacgtggt      660

ctgcgtttga aagagggtat ggtcttaact attgaaccca tgattaatac aggcacttgg      720

gaaattgata ctgatatgaa caccggctgg gcacacaaaa cgcttgatgg cggattatcc      780

tgtcagtatg agcatcaatt tgtcattaca aaagacggtc cccgtattct aacgagtcag      840

ggtcaagaag ggacttatta a                                                861


<210>  19
<211>  286
<212>  PRT
<213>  Streptococcus mutans

<400>  19

Met Ile Thr Leu Lys Ser Gln Arg Glu Ile Glu Ala Met Asp Glu Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Ile Lys 
            20                  25                  30          


Pro Gly Leu Asp Met Trp Lys Ile Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Tyr Leu Pro Leu Gln Ile Gly Val Asp Gly Gln Leu 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Gly Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Gly Gly Pro Ile Ala Lys Glu Asp Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asn Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Asp 
        115                 120                 125             


Ser Phe Arg Gly Gly Val Ala Asp Ser Cys Trp Ala Tyr Ala Val Gly 
    130                 135                 140                 


Asp Val Ser Gln Glu Val Lys Asn Leu Met Ala Val Thr Lys Glu Cys 
145                 150                 155                 160 


Leu Tyr Arg Gly Ile Glu Lys Ala Val Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ala Asn Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             


Pro Asn Val Pro His Tyr Gly Arg Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Met Asn Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Arg Ile Leu Thr Ser Gln Gly Gln Glu Gly Thr Tyr 
        275                 280                 285     


<210>  20
<211>  861
<212>  DNA
<213>  Streptococcus mutans

<400>  20
atgattacgt taaaatcaca gcgtgaaatt gaagcgatgg atgaggcagg tgattttctg       60

gctagcattc atatcggttt gcgtgatttg attaaacccg gacttgatat gtggaaaatt      120

gaagaatatg ttcgcagacg ttgtaaggaa gagaactatc ttcccttaca aattggtgtt      180

gatgggcagc ttatggatta cccctacgca acttgctgcg gactcaatga tgaagttgca      240

cacgcctttc cacgtcatta tatcttgaaa gatggcgatc ttcttaaagt tgatatggta      300

cttggcggtc ccattgctaa agaagaccta gatgtctcaa aattgaattt tgacaatgtg      360

gctcaagtca aaaaatatac agatagtttt cgtggcggtg tggctgattc ctgctgggcc      420

tatgccgttg gcgatgtttc tcaagaagta aagaatctaa tggcagtgac taaagagtgt      480

ctctatcgtg gaattgaaaa ggcagtagtt ggcaatcgta ttggtgacat tggagcagct      540

attcaagaat atgctgaggc caacggttat ggtgtcgtcc gtgatttagt tggtcatggt      600

gttggcccaa ccatgcagga agaacccaat gtaccgcatt atggcagagc aggacgtggt      660

ctgcgtttga aagagggtat ggtcttaact attgaaccca tgattaatac aggcacttgg      720

gaaattgata ctgatatgaa caccggctgg gcacacaaaa cgcttgatgg cggattatcc      780

tgtcagtatg agcatcaatt tgtcattaca aaagacggtc cccgtattct aacgagtcag      840

ggtcaagaag ggacttatta a                                                861


<210>  21
<211>  286
<212>  PRT
<213>  Streptococcus mutans

<400>  21

Met Ile Thr Leu Lys Ser Gln Arg Glu Ile Glu Ala Met Asp Glu Ala 
1               5                   10                  15      


Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Ile Lys 
            20                  25                  30          


Pro Gly Leu Asp Met Trp Lys Ile Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              


Lys Glu Glu Asn Tyr Leu Pro Leu Gln Ile Gly Val Asp Gly Gln Leu 
    50                  55                  60                  


Met Asp Tyr Pro Tyr Ala Thr Cys Cys Gly Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  


His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      


Val Asp Met Val Leu Gly Gly Pro Ile Ala Lys Glu Asp Leu Asp Val 
            100                 105                 110         


Ser Lys Leu Asn Phe Asp Asn Val Ala Gln Val Lys Lys Tyr Thr Asp 
        115                 120                 125             


Ser Phe Arg Gly Gly Val Ala Asp Ser Cys Trp Ala Tyr Ala Val Gly 
    130                 135                 140                 


Asp Val Ser Gln Glu Val Lys Asn Leu Met Ala Val Thr Lys Glu Cys 
145                 150                 155                 160 


Leu Tyr Arg Gly Ile Glu Lys Ala Val Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     


Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ala Asn Gly Tyr Gly Val 
            180                 185                 190         


Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met Gln Glu Glu 
        195                 200                 205             


Pro Asn Val Pro His Tyr Gly Arg Ala Gly Arg Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Thr Trp 
225                 230                 235                 240 


Glu Ile Asp Thr Asp Met Asn Thr Gly Trp Ala His Lys Thr Leu Asp 
                245                 250                 255     


Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         


Gly Pro Arg Ile Leu Thr Ser Gln Gly Gln Glu Gly Thr Tyr 
        275                 280                 285     


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  22
tcaatctact caaggtatga atca                                              24


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  23
gtcagtagta gtggtcaaga                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  24
agttcctgat aggtcgcatt                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  25
gagttggacc aacaatgcag                                                   20


<210>  26
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  26
cagcagcggc ctggtgccgc gcggcagcca aatgattaca ctgaaatcag cacgtg           56


<210>  27
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  27
gccggatctc agtggtggtg gtggtggtgc ttaataagtt ctttcttccc cttgag           56


<210>  28
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  28
attacagctc cagatccagt actgaattct tgagcctgct atgattgact ctgca            55


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  29
attgggttct tcctgcatgg ttgg                                              24


<210>  30
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  30
ccaaccatgc aggaagaacc caat                                              24


<210>  31
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  31
gaaaatatgc actcgagaag cttgagctct ccgaaggtgg acaacataat agc              53


<210>  32
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  32
gaattcgaat tcaaaggctg ttgtgacagc aa                                     32


<210>  33
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  33
ctcgagctcg agttaataag tcccttcttg accc                                   34


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  34
tgctgagaca acctagtctc tc                                                22


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  35
taaacagagc ctccctatcc                                                   20


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  36
ctgagattaa tagtgcgatt acg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  37
gctggatatt cgtataacat gtc                                               23


