﻿               SEQUENCE LISTING

<110> Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
      Philipps-Universität Marburg

<120> Dual inhibition of plexin-B1 and plexin-B2

<130> AC1219 PCT

<150> EP 19 15 6552.2
<151> 2019-02-11

<160> 20

<170> BiSSAP 1.3

<210> 1
<211> 6408
<212> DNA
<213> Homo sapiens

<220> 
<223> Plexin-B1, human, cDNA (coding sequence)

<400> 1
atgcctgctc tgggcccagc tcttctccag gctctctggg ccgggtgggt cctcaccctc       60

cagccccttc caccaactgc attcactccc aatggcacgt atctgcagca cctggcaagg      120

gaccccacct caggcaccct ctacctgggg gctaccaact tcctgttcca gctgagccct      180

gggctgcagc tggaggccac agtgtccacc ggccctgtgc tagacagcag ggactgcctg      240

ccacctgtga tgcctgatga gtgcccccag gcccagccta ccaacaaccc gaatcagctg      300

ctcctggtga gcccaggggc cctggtggta tgcgggagcg tgcaccaggg ggtctgtgaa      360

cagcggcgcc tggggcagct cgagcagctg ctgctgcggc cagagcggcc tggggacaca      420

caatatgtgg ctgccaatga tcctgcggtc agcacggtgg ggctggtagc ccagggcttg      480

gcaggggagc ccctcctgtt tgtggggcga ggatacacca gcaggggtgt ggggggtggc      540

attccaccca tcacaacccg ggccctgtgg ccgcccgacc cccaagctgc cttctcctat      600

gaggagacag ccaagctggc agtgggccgc ctctccgagt acagccacca cttcgtgagt      660

gcctttgcac gtggggccag cgcctacttc ctgttcctgc ggcgggacct gcaggctcag      720

tctagagctt ttcgtgccta tgtatctcga gtgtgtctcc gggaccagca ctactactcc      780

tatgtggagt tgcctctggc ctgcgaaggt ggccgctacg ggctgatcca ggctgcagct      840

gtggccacgt ccagggaggt ggcgcatggg gaggtgctct ttgcagcttt ctcctcggct      900

gcacccccca ctgtgggccg gcccccatcg gcggctgctg gggcatctgg agcctctgcc      960

ctctgtgcct tccccctgga tgaggtggac cggcttgcta atcgcacgcg agatgcctgc     1020

tacacccggg agggtcgtgc tgaggatggg accgaggtgg cctacatcga gtatgatgtc     1080

aattctgact gtgcacagct gccagtggac accctggatg cttatccctg tggctcagac     1140

cacacgccca gccccatggc cagccgggtc ccgctggaag ccacaccaat tctggagtgg     1200

ccagggattc agctaacagc tgtggcagtc accatggaag atggacacac catcgctttc     1260

ctgggtgata gtcaagggca gctgcacagg gtctacttgg gcccagggag cgatggccac     1320

ccatactcca cacagagcat ccagcagggg tctgcagtga gcagagacct cacctttgat     1380

gggacctttg agcacctgta tgtcatgacc cagagcacac ttctgaaggt tcctgtggct     1440

tcctgtgctc agcacctgga ctgtgcatct tgccttgctc acagggaccc atactgtggg     1500

tggtgcgtgc tccttggcag gtgcagtcgc cgttctgagt gctcgagggg ccagggccca     1560

gagcagtggc tatggagctt ccagcctgag ctgggctgtc tgcaagtggc agccatgagt     1620

cctgccaaca tcagccgaga ggagacgagg gaggttttcc tatcagtgcc agacctgcca     1680

cccctgtggc caggggagtc atattcctgc cactttgggg aacatcagag tcctgccctg     1740

ctgactggtt ctggtgtgat gtgcccctcc ccagacccta gtgaggcccc agtgctgccg     1800

agaggagccg actacgtatc cgtgagcgtg gagctcagat ttggcgctgt tgtgatcgcc     1860

aaaacttccc tctctttcta tgactgtgtg gcggtcactg aactccgccc atctgcgcag     1920

tgccaggcct gtgtgagcag ccgctggggg tgtaactggt gtgtctggca gcacctgtgc     1980

acccacaagg cctcgtgtga tgctgggccc atggttgcaa gccatcagag cccgcttgtc     2040

tccccagacc ctcctgcaag aggtggaccc agcccctccc cacccacagc ccccaaagcc     2100

ctggccaccc ctgctcctga cacccttccc gtggagcctg gggctccctc cacagccaca     2160

gcttcggaca tctcacctgg ggctagtcct tccctgctca gcccctgggg gccatgggca     2220

ggttctggct ccatatcttc ccctggctcc acagggtcgc ctctccatga ggagccctcc     2280

cctcccagcc cccaaaatgg acctggaacc gctgtccctg cccccactga cttcagaccc     2340

tcagccacac ctgaggacct cttggcctcc ccgctgtcac cctcagaggt agcagcagtg     2400

ccccctgcag accctggccc cgaggctctt catcccacag tgcccctgga cctgccccct     2460

gccactgttc ctgccaccac tttcccaggg gccatgggct ccgtgaagcc cgccctggac     2520

tggctcacga gagaaggcgg cgagctgccc gaggcggacg agtggacggg gggtgacgca     2580

cccgccttct ccacttccac cctcctctca ggtgatggag actcagcaga gcttgagggc     2640

cctcccgccc ccctcatcct cccgtccagc ctcgactacc agtatgacac ccccgggctc     2700

tgggagctgg aagaggcgac cttgggggca agctcctgcc cctgtgtgga gagcgttcag     2760

ggctccacgt tgatgccggt ccatgtggag cgggaaatcc ggctgctagg caggaacctg     2820

caccttttcc aggatggccc aggagacaat gagtgtgtga tggagctgga gggcctcgag     2880

gtggtggttg aggcccgggt cgagtgtgag ccacctccag atacccagtg ccatgtcacc     2940

tgccagcagc accagctcag ctatgaggct ctgcagccgg agctccgtgt ggggctgttt     3000

ctgcgtcggg ccggccgtct gcgtgtggac agtgctgagg ggctgcatgt ggtactgtat     3060

gactgttccg tgggacatgg agactgcagc cgctgccaaa ctgccatgcc ccagtatggc     3120

tgtgtgtggt gtgaggggga gcgtccacgt tgtgtgaccc gggaggcctg tggtgaggct     3180

gaggctgtgg ccacccagtg cccagcgccc ctcatccact cggtggagcc actgactggg     3240

cctgtagacg gaggcacccg tgtcaccatc aggggctcca acctgggcca gcatgtgcag     3300

gatgtgctgg gcatggtcac ggtggctgga gtgccctgtg ctgtggatgc ccaggagtac     3360

gaggtctcca gcagcctcgt gtgcatcacc ggggccagtg gggaggaggt ggccggcgcc     3420

acagcggtgg aggtgccggg aagaggacgt ggtgtctcag aacacgactt tgcctaccag     3480

gatccgaagg tccattccat cttcccggcc cgcggcccca gagctggggg cacccgtctc     3540

accctgaatg gctccaagct cctgactggg cggctggagg acatccgagt ggtggttgga     3600

gaccagcctt gtcacttgct gccggagcag cagtcagaac aactgcggtg tgagaccagc     3660

ccacgcccca cgcctgccac gctccctgtg gctgtgtggt ttggggccac ggagcggagg     3720

cttcaacgcg gacagttcaa gtataccttg gaccccaaca tcacctctgc tggccccacc     3780

aagagcttcc tcagtggagg acgtgagata tgcgtccgtg gccagaatct ggacgtggta     3840

cagacgccaa gaatccgggt gaccgtggtc tcgagaatgc tgcagcccag ccaggggctt     3900

ggacggaggc gtcgcgtggt cccggagacg gcatgttccc ttggaccctc ctgcagtagc     3960

cagcaatttg aggagccgtg ccatgtcaac tcctcccagc tcatcacgtg ccgcacacct     4020

gccctcccag gcctgcctga ggacccctgg gtccgggtgg aatttatcct tgacaacctg     4080

gtctttgact ttgcaacact gaaccccaca cctttctcct atgaggccga ccccaccctg     4140

cagccactca accctgagga ccccaccatg ccattccggc acaagcctgg gagtgtgttc     4200

tccgtggagg gggagaacct ggaccttgca atgtccaagg aggaggtggt ggctatgata     4260

ggggatggcc cctgtgtggt gaagacgctg acgcggcacc acctgtactg cgagcccccc     4320

gtggagcagc ccctgccacg gcaccatgcc ctccgagagg cacctgactc tttgcctgag     4380

ttcacggtgc agatggggaa cttgcgcttc tccctgggtc acgtgcagta tgacggcgag     4440

agccctgggg cttttcctgt ggcagcccag gtgggcttgg gggtgggcac ctctcttctg     4500

gctctgggtg tcatcatcat tgtcctcatg tacaggagga agagcaagca ggccctgagg     4560

gactataaga aggttcagat ccagctggag aatctggaga gcagtgtgcg ggaccgctgc     4620

aagaaggaat tcacagacct catgactgag atgaccgatc tcaccagtga cctcctgggc     4680

agcggcatcc ccttcctcga ctacaaggtg tatgcggaga ggatcttctt ccctgggcac     4740

cgcgagtcgc ccttgcaccg ggacctgggt gtgcctgaga gcagacggcc cactgtggag     4800

caagggctgg ggcagctctc taacctgctc aacagcaagc tcttcctcac caagttcatc     4860

cacacgctgg agagccagcg caccttttca gctcgggacc gtgcctacgt ggcatctctg     4920

ctcaccgtgg cactgcatgg gaagcttgag tatttcactg acatcctccg cactctgctc     4980

agtgacctgg ttgcccagta tgtggccaag aaccccaagc tgatgctgcg caggacagag     5040

actgtggtgg agaagctgct caccaactgg atgtccatct gtctgtatac cttcgtgagg     5100

gactccgtag gggagcctct gtacatgctc tttcgaggga ttaagcacca agtggataag     5160

gggccagtgg acagtgtgac aggcaaggcc aaatacacct tgaacgacaa ccgcctgctc     5220

agagaggatg tggagtaccg tcccctgacc ttgaatgcac tattggctgt ggggcctggg     5280

gcaggagagg cccagggcgt gcccgtgaag gtcctagact gtgacaccat ctcccaggca     5340

aaggagaaga tgctggacca gctttataaa ggagtgcctc tcacccagcg gccagaccct     5400

cgcacccttg atgttgagtg gcggtctggg gtggccgggc acctcattct ttctgacgag     5460

gatgtcactt ctgaggtcca gggtctgtgg aggcgcctga acacactgca gcattacaag     5520

gtcccagatg gagcaactgt ggccctcgtc ccctgcctca ccaagcatgt gctccgggaa     5580

aaccaggatt atgtccctgg agagcggacc ccaatgctgg aggatgtaga tgaggggggc     5640

atccggccct ggcacctggt gaagccaagt gatgagccgg agccgcccag gcctcggagg     5700

ggcagccttc ggggcgggga gcgtgagcgc gccaaggcca tccctgagat ctacctgacc     5760

cgcctgctgt ccatgaaggg caccctgcag aagttcgtgg atgacctgtt ccaggtgatt     5820

ctcagcacca gccgccccgt gccgctcgct gtgaagtact tctttgacct gctggatgag     5880

caggcccagc agcatggcat ctccgaccag gacaccatcc acatctggaa gaccaacagc     5940

ttgcctctga ggttctggat caatataata aaaaacccgc agtttgtgtt cgacgtgcaa     6000

acatctgata acatggatgc ggtgctcctt gtcattgcac agaccttcat ggacgcctgc     6060

accctggccg accacaagct gggccgggac tccccgatca acaaacttct gtatgcacgg     6120

gacattcccc ggtacaagcg gatggtggaa aggtactatg cagacatcag acagactgtc     6180

ccagccagcg accaagagat gaactctgtc ctggctgaac tgtcctggaa ctactccgga     6240

gacctcgggg cgcgagtggc cctgcatgaa ctctacaagt acatcaacaa gtactatgac     6300

cagatcatca ctgccctgga ggaggatggc acggcccaga agatgcagct gggctatcgg     6360

ctccagcaga ttgcagctgc tgtggaaaac aaggtcacag atctatag                  6408


<210> 2
<211> 5517
<212> DNA
<213> Homo sapiens

<220> 
<223> Plexin-B2, human, cDNA (coding sequence)

<400> 2
atggcactgc agctctgggc cctgaccctg ctgggcctgc tgggcgcagg tgccagcctg       60

aggccccgca agctggactt cttccgcagc gagaaagagc tgaaccacct ggctgtggat      120

gaggcctcag gcgtggtgta cctgggggcg gtgaatgccc tctaccagct ggatgcgaag      180

ctgcagctgg agcagcaggt ggccacgggc ccggccctgg acaacaagaa gtgcacgccg      240

cccatcgagg ccagccagtg ccatgaggct gagatgactg acaatgtcaa ccagctgctg      300

ctgctcgacc ctcccaggaa gcgcctggtg gagtgcggca gcctcttcaa gggcatctgc      360

gctctgcgcg ccctgagcaa catctccctc cgcctgttct acgaggacgg cagcggggag      420

aagtctttcg tggccagcaa tgatgagggc gtggccacag tggggctggt gagctccacg      480

ggtcctggtg gtgaccgcgt gctgtttgtg ggcaaaggca atgggccaca cgacaacggc      540

atcatcgtga gcactcggct gttggaccgg actgacagca gggaggcctt tgaagcctac      600

acggaccacg ccacctacaa ggccggctac ctgtccacca acacacagca gttcgtggcg      660

gccttcgagg acggccccta cgtcttcttt gtcttcaacc agcaggacaa gcacccggcc      720

cggaaccgca cgctgctggc acgcatgtgc agagaagacc ccaactacta ctcctacctg      780

gagatggacc tgcagtgccg ggaccccgac atccacgccg ctgcctttgg cacctgcctg      840

gccgcctccg tggctgcgcc tggctctggc agggtgctat atgctgtctt cagcagagac      900

agccggagca gtggggggcc cggtgcgggc ctctgcctgt tcccgctgga caaggtgcac      960

gccaagatgg aggccaaccg caacgcctgt tacacaggca cccgggaggc ccgtgacatc     1020

ttctacaagc ccttccacgg cgatatccag tgcggcggcc acgcgccggg ctccagcaag     1080

agcttcccat gtggctcgga gcacctgccc tacccgctgg gcagccgcga cgggctcaga     1140

ggcacagccg tgctgcagcg tggaggcctg aacctcacgg ccgtgacggt cgccgccgag     1200

aacaaccaca ctgttgcttt tctgggcacc tctgatggcc ggatcctcaa ggtgtacctc     1260

accccagatg gcacctcctc agagtacgac tctatccttg tggagataaa caagagagtc     1320

aagcgcgacc tggtactgtc tggagacctg ggcagcctgt acgccatgac ccaggacaag     1380

gtgttccggc tgccggtgca ggagtgcctg agctacccga cctgcaccca gtgccgcgac     1440

tcccaggacc cctactgcgg ctggtgcgtc gtcgagggac gatgcacccg gaaggccgag     1500

tgtccgcggg ccgaggaggc cagccactgg ctgtggagcc gaagcaagtc ctgcgtggcc     1560

gtcaccagcg cccagccaca gaacatgagc cggcgggccc agggggaggt gcagctgacc     1620

gtcagccccc tccctgccct gagcgaggag gacgagttgc tgtgcctttt tggggagtcg     1680

ccgccacacc ccgcccgcgt ggagggcgag gccgtcatct gcaactcccc aagcagcatc     1740

cccgtcacac cgccaggcca ggaccacgtg gccgtgacca tccagctcct ccttagacga     1800

ggcaacatct tcctcacgtc ctaccagtac cccttctacg actgccgcca ggccatgagc     1860

ctggaggaga acctgccgtg catctcctgc gtgagcaacc gctggacctg ccagtgggac     1920

ctgcgctacc acgagtgccg ggaggcttcg cccaaccctg aggacggcat cgtccgtgcc     1980

cacatggagg acagctgtcc ccagttcctg ggacccagcc ccctggtgat ccccatgaac     2040

cacgagacag atgtgaactt ccagggcaag aacctggaca ccgtgaaggg ttcctccctg     2100

cacgtgggca gtgacttgct caagttcatg gagccggtga ccatgcagga atctgggacc     2160

ttcgcctttc ggaccccaaa gctgtcccac gatgccaacg agacgctgcc cctgcacctc     2220

tacgtcaagt cttacggcaa gaatatcgac agcaagctcc atgtgaccct ctacaactgc     2280

tcctttggcc gcagcgactg cagcctgtgc cgggccgcta accccgacta caggtgtgcg     2340

tggtgcgggg gccagagcag gtgcgtgtat gaggccctgt gcaacaccac ctccgagtgc     2400

ccgccgcccg tcatcaccag gatccagcct gagacgggcc ccctgggtgg gggcatccgc     2460

atcaccatcc tggggtccaa tttgggcgtc caagcagggg acatccagag gatctctgtg     2520

gccggccgga actgctcctt tcagccggaa cgttactccg tgtccacccg gatcgtgtgt     2580

gtgatcgagg ctgcggagac gcctttcacg gggggtgtcg aggtggacgt cttcgggaaa     2640

ctgggccgtt cgcctcccaa tgtccagttc accttccaac agcccaagcc tctcagtgtg     2700

gagccgcagc agggaccgca ggcgggcggc accacactga ccatccacgg cacccacctg     2760

gacacgggct cccaggagga cgtgcgggtg accctcaacg gcgtcccgtg taaagtgacg     2820

aagtttgggg cgcagctcca gtgtgtcact ggcccccagg cgacacgggg ccagatgctt     2880

ctggaggtct cctacggggg gtcccccgtg cccaaccccg gcatcttctt cacctaccgc     2940

gaaaaccccg tactgcgagc cttcgagccg ctacgaagct ttgccagtgg tggccgcagc     3000

atcaacgtca cgggtcaggg cttcagcctg atccagaggt ttgccatggt ggtcatcgcg     3060

gagcccctgc agtcctggca gccgccgcgg gaggctgaat ccctgcagcc catgacggtg     3120

gtgggtacag actacgtgtt ccacaatgac accaaggtcg tcttcctgtc cccggctgtg     3180

cctgaggagc cagaggccta caacctcacg gtgctgatcg agatggacgg gcaccgtgcc     3240

ctgctcagaa cagaggccgg ggccttcgag tacgtgcctg accccacctt tgagaacttc     3300

acaggtggcg tcaagaagca ggtcaacaag ctcatccacg cccggggcac caatctgaac     3360

aaggcgatga cgctgcagga ggccgaggcc ttcgtgggtg ccgagcgctg caccatgaag     3420

acgctgacgg agaccgacct gtactgtgag cccccggagg tgcagccccc gcccaagcgg     3480

cggcagaaac gagacaccac acacaacctg cccgagttca ttgtgaagtt cggctctcgc     3540

gagtgggtgc tgggccgcgt ggagtacgac acacgggtga gcgacgtgcc gctcagcctc     3600

atcttgccgc tggtcatcgt gcccatggtg gtcgtcatcg cggtgtctgt ctactgctac     3660

tggaggaaga gccagcaggc cgaacgagag tatgagaaga tcaagtccca gctggagggc     3720

ctggaggaga gcgtgcggga ccgctgcaag aaggaattca cagacctgat gatcgagatg     3780

gaggaccaga ccaacgacgt gcacgaggcc ggcatccccg tgctggacta caagacctac     3840

accgaccgcg tcttcttcct gccctccaag gacggcgaca aggacgtgat gatcaccggc     3900

aagctggaca tccctgagcc gcggcggccg gtggtggagc aggccctcta ccagttctcc     3960

aacctgctga acagcaagtc tttcctcatc aatttcatcc acaccctgga gaaccagcgg     4020

gagttctcgg cccgcgccaa ggtctacttc gcgtccctgc tgacggtggc gctgcacggg     4080

aaactggagt actacacgga catcatgcac acgctcttcc tggagctcct ggagcagtac     4140

gtggtggcca agaaccccaa gctgatgctg cgcaggtctg agactgtggt ggagaggatg     4200

ctgtccaact ggatgtccat ctgcctgtac cagtacctca aggacagtgc cggggagccc     4260

ctgtacaagc tcttcaaggc catcaaacat caggtggaaa agggcccggt ggatgcggta     4320

cagaagaagg ccaagtacac tctcaacgac acggggctgc tgggggatga tgtggagtac     4380

gcacccctga cggtgagcgt gatcgtgcag gacgagggag tggacgccat cccggtgaag     4440

gtcctcaact gtgacaccat ctcccaggtc aaggagaaga tcattgacca ggtgtaccgt     4500

gggcagccct gctcctgctg gcccaggcca gacagcgtgg tcctggagtg gcgtccgggc     4560

tccacagcgc agatcctgtc ggacctggac ctgacgtcac agcgggaggg ccggtggaag     4620

cgcgtcaaca cccttatgca ctacaatgtc cgggatggag ccaccctcat cctgtccaag     4680

gtgggggtct cccagcagcc ggaggacagc cagcaggacc tgcctgggga gcgccatgcc     4740

ctcctggagg aggagaaccg ggtgtggcac ctggtgcggc cgaccgacga ggtggacgag     4800

ggcaagtcca agagaggcag cgtgaaagag aaggagcgga cgaaggccat caccgagatc     4860

tacctgacgc ggctgctctc agtcaagggc acactgcagc agtttgtgga caacttcttc     4920

cagagcgtgc tggcgcctgg gcacgcggtg ccacctgcag tcaagtactt cttcgacttc     4980

ctggacgagc aggcagagaa gcacaacatc caggatgaag acaccatcca catctggaag     5040

acgaacagct taccgctccg gttctgggtg aacatcctca agaaccccca cttcatcttt     5100

gacgtgcatg tccacgaggt ggtggacgcc tcgctgtcag tcatcgcgca gaccttcatg     5160

gatgcctgca cgcgcacgga gcataagctg agccgcgatt ctcccagcaa caagctgctg     5220

tacgccaagg agatctccac ctacaagaag atggtggagg attactacaa ggggatccgg     5280

cagatggtgc aggtcagcga ccaggacatg aacacacacc tggcagagat ttcccgggcg     5340

cacacggact ccttgaacac cctcgtggca ctccaccagc tctaccaata cacgcagaag     5400

tactatgacg agatcatcaa tgccttggag gaggatcctg ccgcccagaa gatgcagctg     5460

gccttccgcc tgcagcagat tgccgctgca ctggagaaca aggtcactga cctctga        5517


<210> 3
<211> 2135
<212> PRT
<213> Homo sapiens

<220> 
<223> Plexin-B1, human, Protein

<400> 3
Met Pro Ala Leu Gly Pro Ala Leu Leu Gln Ala Leu Trp Ala Gly Trp 
1               5                   10                  15      
Val Leu Thr Leu Gln Pro Leu Pro Pro Thr Ala Phe Thr Pro Asn Gly 
            20                  25                  30          
Thr Tyr Leu Gln His Leu Ala Arg Asp Pro Thr Ser Gly Thr Leu Tyr 
        35                  40                  45              
Leu Gly Ala Thr Asn Phe Leu Phe Gln Leu Ser Pro Gly Leu Gln Leu 
    50                  55                  60                  
Glu Ala Thr Val Ser Thr Gly Pro Val Leu Asp Ser Arg Asp Cys Leu 
65                  70                  75                  80  
Pro Pro Val Met Pro Asp Glu Cys Pro Gln Ala Gln Pro Thr Asn Asn 
                85                  90                  95      
Pro Asn Gln Leu Leu Leu Val Ser Pro Gly Ala Leu Val Val Cys Gly 
            100                 105                 110         
Ser Val His Gln Gly Val Cys Glu Gln Arg Arg Leu Gly Gln Leu Glu 
        115                 120                 125             
Gln Leu Leu Leu Arg Pro Glu Arg Pro Gly Asp Thr Gln Tyr Val Ala 
    130                 135                 140                 
Ala Asn Asp Pro Ala Val Ser Thr Val Gly Leu Val Ala Gln Gly Leu 
145                 150                 155                 160 
Ala Gly Glu Pro Leu Leu Phe Val Gly Arg Gly Tyr Thr Ser Arg Gly 
                165                 170                 175     
Val Gly Gly Gly Ile Pro Pro Ile Thr Thr Arg Ala Leu Trp Pro Pro 
            180                 185                 190         
Asp Pro Gln Ala Ala Phe Ser Tyr Glu Glu Thr Ala Lys Leu Ala Val 
        195                 200                 205             
Gly Arg Leu Ser Glu Tyr Ser His His Phe Val Ser Ala Phe Ala Arg 
    210                 215                 220                 
Gly Ala Ser Ala Tyr Phe Leu Phe Leu Arg Arg Asp Leu Gln Ala Gln 
225                 230                 235                 240 
Ser Arg Ala Phe Arg Ala Tyr Val Ser Arg Val Cys Leu Arg Asp Gln 
                245                 250                 255     
His Tyr Tyr Ser Tyr Val Glu Leu Pro Leu Ala Cys Glu Gly Gly Arg 
            260                 265                 270         
Tyr Gly Leu Ile Gln Ala Ala Ala Val Ala Thr Ser Arg Glu Val Ala 
        275                 280                 285             
His Gly Glu Val Leu Phe Ala Ala Phe Ser Ser Ala Ala Pro Pro Thr 
    290                 295                 300                 
Val Gly Arg Pro Pro Ser Ala Ala Ala Gly Ala Ser Gly Ala Ser Ala 
305                 310                 315                 320 
Leu Cys Ala Phe Pro Leu Asp Glu Val Asp Arg Leu Ala Asn Arg Thr 
                325                 330                 335     
Arg Asp Ala Cys Tyr Thr Arg Glu Gly Arg Ala Glu Asp Gly Thr Glu 
            340                 345                 350         
Val Ala Tyr Ile Glu Tyr Asp Val Asn Ser Asp Cys Ala Gln Leu Pro 
        355                 360                 365             
Val Asp Thr Leu Asp Ala Tyr Pro Cys Gly Ser Asp His Thr Pro Ser 
    370                 375                 380                 
Pro Met Ala Ser Arg Val Pro Leu Glu Ala Thr Pro Ile Leu Glu Trp 
385                 390                 395                 400 
Pro Gly Ile Gln Leu Thr Ala Val Ala Val Thr Met Glu Asp Gly His 
                405                 410                 415     
Thr Ile Ala Phe Leu Gly Asp Ser Gln Gly Gln Leu His Arg Val Tyr 
            420                 425                 430         
Leu Gly Pro Gly Ser Asp Gly His Pro Tyr Ser Thr Gln Ser Ile Gln 
        435                 440                 445             
Gln Gly Ser Ala Val Ser Arg Asp Leu Thr Phe Asp Gly Thr Phe Glu 
    450                 455                 460                 
His Leu Tyr Val Met Thr Gln Ser Thr Leu Leu Lys Val Pro Val Ala 
465                 470                 475                 480 
Ser Cys Ala Gln His Leu Asp Cys Ala Ser Cys Leu Ala His Arg Asp 
                485                 490                 495     
Pro Tyr Cys Gly Trp Cys Val Leu Leu Gly Arg Cys Ser Arg Arg Ser 
            500                 505                 510         
Glu Cys Ser Arg Gly Gln Gly Pro Glu Gln Trp Leu Trp Ser Phe Gln 
        515                 520                 525             
Pro Glu Leu Gly Cys Leu Gln Val Ala Ala Met Ser Pro Ala Asn Ile 
    530                 535                 540                 
Ser Arg Glu Glu Thr Arg Glu Val Phe Leu Ser Val Pro Asp Leu Pro 
545                 550                 555                 560 
Pro Leu Trp Pro Gly Glu Ser Tyr Ser Cys His Phe Gly Glu His Gln 
                565                 570                 575     
Ser Pro Ala Leu Leu Thr Gly Ser Gly Val Met Cys Pro Ser Pro Asp 
            580                 585                 590         
Pro Ser Glu Ala Pro Val Leu Pro Arg Gly Ala Asp Tyr Val Ser Val 
        595                 600                 605             
Ser Val Glu Leu Arg Phe Gly Ala Val Val Ile Ala Lys Thr Ser Leu 
    610                 615                 620                 
Ser Phe Tyr Asp Cys Val Ala Val Thr Glu Leu Arg Pro Ser Ala Gln 
625                 630                 635                 640 
Cys Gln Ala Cys Val Ser Ser Arg Trp Gly Cys Asn Trp Cys Val Trp 
                645                 650                 655     
Gln His Leu Cys Thr His Lys Ala Ser Cys Asp Ala Gly Pro Met Val 
            660                 665                 670         
Ala Ser His Gln Ser Pro Leu Val Ser Pro Asp Pro Pro Ala Arg Gly 
        675                 680                 685             
Gly Pro Ser Pro Ser Pro Pro Thr Ala Pro Lys Ala Leu Ala Thr Pro 
    690                 695                 700                 
Ala Pro Asp Thr Leu Pro Val Glu Pro Gly Ala Pro Ser Thr Ala Thr 
705                 710                 715                 720 
Ala Ser Asp Ile Ser Pro Gly Ala Ser Pro Ser Leu Leu Ser Pro Trp 
                725                 730                 735     
Gly Pro Trp Ala Gly Ser Gly Ser Ile Ser Ser Pro Gly Ser Thr Gly 
            740                 745                 750         
Ser Pro Leu His Glu Glu Pro Ser Pro Pro Ser Pro Gln Asn Gly Pro 
        755                 760                 765             
Gly Thr Ala Val Pro Ala Pro Thr Asp Phe Arg Pro Ser Ala Thr Pro 
    770                 775                 780                 
Glu Asp Leu Leu Ala Ser Pro Leu Ser Pro Ser Glu Val Ala Ala Val 
785                 790                 795                 800 
Pro Pro Ala Asp Pro Gly Pro Glu Ala Leu His Pro Thr Val Pro Leu 
                805                 810                 815     
Asp Leu Pro Pro Ala Thr Val Pro Ala Thr Thr Phe Pro Gly Ala Met 
            820                 825                 830         
Gly Ser Val Lys Pro Ala Leu Asp Trp Leu Thr Arg Glu Gly Gly Glu 
        835                 840                 845             
Leu Pro Glu Ala Asp Glu Trp Thr Gly Gly Asp Ala Pro Ala Phe Ser 
    850                 855                 860                 
Thr Ser Thr Leu Leu Ser Gly Asp Gly Asp Ser Ala Glu Leu Glu Gly 
865                 870                 875                 880 
Pro Pro Ala Pro Leu Ile Leu Pro Ser Ser Leu Asp Tyr Gln Tyr Asp 
                885                 890                 895     
Thr Pro Gly Leu Trp Glu Leu Glu Glu Ala Thr Leu Gly Ala Ser Ser 
            900                 905                 910         
Cys Pro Cys Val Glu Ser Val Gln Gly Ser Thr Leu Met Pro Val His 
        915                 920                 925             
Val Glu Arg Glu Ile Arg Leu Leu Gly Arg Asn Leu His Leu Phe Gln 
    930                 935                 940                 
Asp Gly Pro Gly Asp Asn Glu Cys Val Met Glu Leu Glu Gly Leu Glu 
945                 950                 955                 960 
Val Val Val Glu Ala Arg Val Glu Cys Glu Pro Pro Pro Asp Thr Gln 
                965                 970                 975     
Cys His Val Thr Cys Gln Gln His Gln Leu Ser Tyr Glu Ala Leu Gln 
            980                 985                 990         
Pro Glu Leu Arg Val Gly Leu Phe Leu Arg Arg Ala Gly Arg Leu Arg 
        995                 1000                1005            
Val Asp Ser Ala Glu Gly Leu His Val Val Leu Tyr Asp Cys Ser Val 
    1010                1015                1020                
Gly His Gly Asp Cys Ser Arg Cys Gln Thr Ala Met Pro Gln Tyr Gly 
1025                1030                1035                1040
Cys Val Trp Cys Glu Gly Glu Arg Pro Arg Cys Val Thr Arg Glu Ala 
                1045                1050                1055    
Cys Gly Glu Ala Glu Ala Val Ala Thr Gln Cys Pro Ala Pro Leu Ile 
            1060                1065                1070        
His Ser Val Glu Pro Leu Thr Gly Pro Val Asp Gly Gly Thr Arg Val 
        1075                1080                1085            
Thr Ile Arg Gly Ser Asn Leu Gly Gln His Val Gln Asp Val Leu Gly 
    1090                1095                1100                
Met Val Thr Val Ala Gly Val Pro Cys Ala Val Asp Ala Gln Glu Tyr 
1105                1110                1115                1120
Glu Val Ser Ser Ser Leu Val Cys Ile Thr Gly Ala Ser Gly Glu Glu 
                1125                1130                1135    
Val Ala Gly Ala Thr Ala Val Glu Val Pro Gly Arg Gly Arg Gly Val 
            1140                1145                1150        
Ser Glu His Asp Phe Ala Tyr Gln Asp Pro Lys Val His Ser Ile Phe 
        1155                1160                1165            
Pro Ala Arg Gly Pro Arg Ala Gly Gly Thr Arg Leu Thr Leu Asn Gly 
    1170                1175                1180                
Ser Lys Leu Leu Thr Gly Arg Leu Glu Asp Ile Arg Val Val Val Gly 
1185                1190                1195                1200
Asp Gln Pro Cys His Leu Leu Pro Glu Gln Gln Ser Glu Gln Leu Arg 
                1205                1210                1215    
Cys Glu Thr Ser Pro Arg Pro Thr Pro Ala Thr Leu Pro Val Ala Val 
            1220                1225                1230        
Trp Phe Gly Ala Thr Glu Arg Arg Leu Gln Arg Gly Gln Phe Lys Tyr 
        1235                1240                1245            
Thr Leu Asp Pro Asn Ile Thr Ser Ala Gly Pro Thr Lys Ser Phe Leu 
    1250                1255                1260                
Ser Gly Gly Arg Glu Ile Cys Val Arg Gly Gln Asn Leu Asp Val Val 
1265                1270                1275                1280
Gln Thr Pro Arg Ile Arg Val Thr Val Val Ser Arg Met Leu Gln Pro 
                1285                1290                1295    
Ser Gln Gly Leu Gly Arg Arg Arg Arg Val Val Pro Glu Thr Ala Cys 
            1300                1305                1310        
Ser Leu Gly Pro Ser Cys Ser Ser Gln Gln Phe Glu Glu Pro Cys His 
        1315                1320                1325            
Val Asn Ser Ser Gln Leu Ile Thr Cys Arg Thr Pro Ala Leu Pro Gly 
    1330                1335                1340                
Leu Pro Glu Asp Pro Trp Val Arg Val Glu Phe Ile Leu Asp Asn Leu 
1345                1350                1355                1360
Val Phe Asp Phe Ala Thr Leu Asn Pro Thr Pro Phe Ser Tyr Glu Ala 
                1365                1370                1375    
Asp Pro Thr Leu Gln Pro Leu Asn Pro Glu Asp Pro Thr Met Pro Phe 
            1380                1385                1390        
Arg His Lys Pro Gly Ser Val Phe Ser Val Glu Gly Glu Asn Leu Asp 
        1395                1400                1405            
Leu Ala Met Ser Lys Glu Glu Val Val Ala Met Ile Gly Asp Gly Pro 
    1410                1415                1420                
Cys Val Val Lys Thr Leu Thr Arg His His Leu Tyr Cys Glu Pro Pro 
1425                1430                1435                1440
Val Glu Gln Pro Leu Pro Arg His His Ala Leu Arg Glu Ala Pro Asp 
                1445                1450                1455    
Ser Leu Pro Glu Phe Thr Val Gln Met Gly Asn Leu Arg Phe Ser Leu 
            1460                1465                1470        
Gly His Val Gln Tyr Asp Gly Glu Ser Pro Gly Ala Phe Pro Val Ala 
        1475                1480                1485            
Ala Gln Val Gly Leu Gly Val Gly Thr Ser Leu Leu Ala Leu Gly Val 
    1490                1495                1500                
Ile Ile Ile Val Leu Met Tyr Arg Arg Lys Ser Lys Gln Ala Leu Arg 
1505                1510                1515                1520
Asp Tyr Lys Lys Val Gln Ile Gln Leu Glu Asn Leu Glu Ser Ser Val 
                1525                1530                1535    
Arg Asp Arg Cys Lys Lys Glu Phe Thr Asp Leu Met Thr Glu Met Thr 
            1540                1545                1550        
Asp Leu Thr Ser Asp Leu Leu Gly Ser Gly Ile Pro Phe Leu Asp Tyr 
        1555                1560                1565            
Lys Val Tyr Ala Glu Arg Ile Phe Phe Pro Gly His Arg Glu Ser Pro 
    1570                1575                1580                
Leu His Arg Asp Leu Gly Val Pro Glu Ser Arg Arg Pro Thr Val Glu 
1585                1590                1595                1600
Gln Gly Leu Gly Gln Leu Ser Asn Leu Leu Asn Ser Lys Leu Phe Leu 
                1605                1610                1615    
Thr Lys Phe Ile His Thr Leu Glu Ser Gln Arg Thr Phe Ser Ala Arg 
            1620                1625                1630        
Asp Arg Ala Tyr Val Ala Ser Leu Leu Thr Val Ala Leu His Gly Lys 
        1635                1640                1645            
Leu Glu Tyr Phe Thr Asp Ile Leu Arg Thr Leu Leu Ser Asp Leu Val 
    1650                1655                1660                
Ala Gln Tyr Val Ala Lys Asn Pro Lys Leu Met Leu Arg Arg Thr Glu 
1665                1670                1675                1680
Thr Val Val Glu Lys Leu Leu Thr Asn Trp Met Ser Ile Cys Leu Tyr 
                1685                1690                1695    
Thr Phe Val Arg Asp Ser Val Gly Glu Pro Leu Tyr Met Leu Phe Arg 
            1700                1705                1710        
Gly Ile Lys His Gln Val Asp Lys Gly Pro Val Asp Ser Val Thr Gly 
        1715                1720                1725            
Lys Ala Lys Tyr Thr Leu Asn Asp Asn Arg Leu Leu Arg Glu Asp Val 
    1730                1735                1740                
Glu Tyr Arg Pro Leu Thr Leu Asn Ala Leu Leu Ala Val Gly Pro Gly 
1745                1750                1755                1760
Ala Gly Glu Ala Gln Gly Val Pro Val Lys Val Leu Asp Cys Asp Thr 
                1765                1770                1775    
Ile Ser Gln Ala Lys Glu Lys Met Leu Asp Gln Leu Tyr Lys Gly Val 
            1780                1785                1790        
Pro Leu Thr Gln Arg Pro Asp Pro Arg Thr Leu Asp Val Glu Trp Arg 
        1795                1800                1805            
Ser Gly Val Ala Gly His Leu Ile Leu Ser Asp Glu Asp Val Thr Ser 
    1810                1815                1820                
Glu Val Gln Gly Leu Trp Arg Arg Leu Asn Thr Leu Gln His Tyr Lys 
1825                1830                1835                1840
Val Pro Asp Gly Ala Thr Val Ala Leu Val Pro Cys Leu Thr Lys His 
                1845                1850                1855    
Val Leu Arg Glu Asn Gln Asp Tyr Val Pro Gly Glu Arg Thr Pro Met 
            1860                1865                1870        
Leu Glu Asp Val Asp Glu Gly Gly Ile Arg Pro Trp His Leu Val Lys 
        1875                1880                1885            
Pro Ser Asp Glu Pro Glu Pro Pro Arg Pro Arg Arg Gly Ser Leu Arg 
    1890                1895                1900                
Gly Gly Glu Arg Glu Arg Ala Lys Ala Ile Pro Glu Ile Tyr Leu Thr 
1905                1910                1915                1920
Arg Leu Leu Ser Met Lys Gly Thr Leu Gln Lys Phe Val Asp Asp Leu 
                1925                1930                1935    
Phe Gln Val Ile Leu Ser Thr Ser Arg Pro Val Pro Leu Ala Val Lys 
            1940                1945                1950        
Tyr Phe Phe Asp Leu Leu Asp Glu Gln Ala Gln Gln His Gly Ile Ser 
        1955                1960                1965            
Asp Gln Asp Thr Ile His Ile Trp Lys Thr Asn Ser Leu Pro Leu Arg 
    1970                1975                1980                
Phe Trp Ile Asn Ile Ile Lys Asn Pro Gln Phe Val Phe Asp Val Gln 
1985                1990                1995                2000
Thr Ser Asp Asn Met Asp Ala Val Leu Leu Val Ile Ala Gln Thr Phe 
                2005                2010                2015    
Met Asp Ala Cys Thr Leu Ala Asp His Lys Leu Gly Arg Asp Ser Pro 
            2020                2025                2030        
Ile Asn Lys Leu Leu Tyr Ala Arg Asp Ile Pro Arg Tyr Lys Arg Met 
        2035                2040                2045            
Val Glu Arg Tyr Tyr Ala Asp Ile Arg Gln Thr Val Pro Ala Ser Asp 
    2050                2055                2060                
Gln Glu Met Asn Ser Val Leu Ala Glu Leu Ser Trp Asn Tyr Ser Gly 
2065                2070                2075                2080
Asp Leu Gly Ala Arg Val Ala Leu His Glu Leu Tyr Lys Tyr Ile Asn 
                2085                2090                2095    
Lys Tyr Tyr Asp Gln Ile Ile Thr Ala Leu Glu Glu Asp Gly Thr Ala 
            2100                2105                2110        
Gln Lys Met Gln Leu Gly Tyr Arg Leu Gln Gln Ile Ala Ala Ala Val 
        2115                2120                2125            
Glu Asn Lys Val Thr Asp Leu 
    2130                2135

<210> 4
<211> 1838
<212> PRT
<213> Homo sapiens

<220> 
<223> Plexin-B2, human, Protein

<400> 4
Met Ala Leu Gln Leu Trp Ala Leu Thr Leu Leu Gly Leu Leu Gly Ala 
1               5                   10                  15      
Gly Ala Ser Leu Arg Pro Arg Lys Leu Asp Phe Phe Arg Ser Glu Lys 
            20                  25                  30          
Glu Leu Asn His Leu Ala Val Asp Glu Ala Ser Gly Val Val Tyr Leu 
        35                  40                  45              
Gly Ala Val Asn Ala Leu Tyr Gln Leu Asp Ala Lys Leu Gln Leu Glu 
    50                  55                  60                  
Gln Gln Val Ala Thr Gly Pro Ala Leu Asp Asn Lys Lys Cys Thr Pro 
65                  70                  75                  80  
Pro Ile Glu Ala Ser Gln Cys His Glu Ala Glu Met Thr Asp Asn Val 
                85                  90                  95      
Asn Gln Leu Leu Leu Leu Asp Pro Pro Arg Lys Arg Leu Val Glu Cys 
            100                 105                 110         
Gly Ser Leu Phe Lys Gly Ile Cys Ala Leu Arg Ala Leu Ser Asn Ile 
        115                 120                 125             
Ser Leu Arg Leu Phe Tyr Glu Asp Gly Ser Gly Glu Lys Ser Phe Val 
    130                 135                 140                 
Ala Ser Asn Asp Glu Gly Val Ala Thr Val Gly Leu Val Ser Ser Thr 
145                 150                 155                 160 
Gly Pro Gly Gly Asp Arg Val Leu Phe Val Gly Lys Gly Asn Gly Pro 
                165                 170                 175     
His Asp Asn Gly Ile Ile Val Ser Thr Arg Leu Leu Asp Arg Thr Asp 
            180                 185                 190         
Ser Arg Glu Ala Phe Glu Ala Tyr Thr Asp His Ala Thr Tyr Lys Ala 
        195                 200                 205             
Gly Tyr Leu Ser Thr Asn Thr Gln Gln Phe Val Ala Ala Phe Glu Asp 
    210                 215                 220                 
Gly Pro Tyr Val Phe Phe Val Phe Asn Gln Gln Asp Lys His Pro Ala 
225                 230                 235                 240 
Arg Asn Arg Thr Leu Leu Ala Arg Met Cys Arg Glu Asp Pro Asn Tyr 
                245                 250                 255     
Tyr Ser Tyr Leu Glu Met Asp Leu Gln Cys Arg Asp Pro Asp Ile His 
            260                 265                 270         
Ala Ala Ala Phe Gly Thr Cys Leu Ala Ala Ser Val Ala Ala Pro Gly 
        275                 280                 285             
Ser Gly Arg Val Leu Tyr Ala Val Phe Ser Arg Asp Ser Arg Ser Ser 
    290                 295                 300                 
Gly Gly Pro Gly Ala Gly Leu Cys Leu Phe Pro Leu Asp Lys Val His 
305                 310                 315                 320 
Ala Lys Met Glu Ala Asn Arg Asn Ala Cys Tyr Thr Gly Thr Arg Glu 
                325                 330                 335     
Ala Arg Asp Ile Phe Tyr Lys Pro Phe His Gly Asp Ile Gln Cys Gly 
            340                 345                 350         
Gly His Ala Pro Gly Ser Ser Lys Ser Phe Pro Cys Gly Ser Glu His 
        355                 360                 365             
Leu Pro Tyr Pro Leu Gly Ser Arg Asp Gly Leu Arg Gly Thr Ala Val 
    370                 375                 380                 
Leu Gln Arg Gly Gly Leu Asn Leu Thr Ala Val Thr Val Ala Ala Glu 
385                 390                 395                 400 
Asn Asn His Thr Val Ala Phe Leu Gly Thr Ser Asp Gly Arg Ile Leu 
                405                 410                 415     
Lys Val Tyr Leu Thr Pro Asp Gly Thr Ser Ser Glu Tyr Asp Ser Ile 
            420                 425                 430         
Leu Val Glu Ile Asn Lys Arg Val Lys Arg Asp Leu Val Leu Ser Gly 
        435                 440                 445             
Asp Leu Gly Ser Leu Tyr Ala Met Thr Gln Asp Lys Val Phe Arg Leu 
    450                 455                 460                 
Pro Val Gln Glu Cys Leu Ser Tyr Pro Thr Cys Thr Gln Cys Arg Asp 
465                 470                 475                 480 
Ser Gln Asp Pro Tyr Cys Gly Trp Cys Val Val Glu Gly Arg Cys Thr 
                485                 490                 495     
Arg Lys Ala Glu Cys Pro Arg Ala Glu Glu Ala Ser His Trp Leu Trp 
            500                 505                 510         
Ser Arg Ser Lys Ser Cys Val Ala Val Thr Ser Ala Gln Pro Gln Asn 
        515                 520                 525             
Met Ser Arg Arg Ala Gln Gly Glu Val Gln Leu Thr Val Ser Pro Leu 
    530                 535                 540                 
Pro Ala Leu Ser Glu Glu Asp Glu Leu Leu Cys Leu Phe Gly Glu Ser 
545                 550                 555                 560 
Pro Pro His Pro Ala Arg Val Glu Gly Glu Ala Val Ile Cys Asn Ser 
                565                 570                 575     
Pro Ser Ser Ile Pro Val Thr Pro Pro Gly Gln Asp His Val Ala Val 
            580                 585                 590         
Thr Ile Gln Leu Leu Leu Arg Arg Gly Asn Ile Phe Leu Thr Ser Tyr 
        595                 600                 605             
Gln Tyr Pro Phe Tyr Asp Cys Arg Gln Ala Met Ser Leu Glu Glu Asn 
    610                 615                 620                 
Leu Pro Cys Ile Ser Cys Val Ser Asn Arg Trp Thr Cys Gln Trp Asp 
625                 630                 635                 640 
Leu Arg Tyr His Glu Cys Arg Glu Ala Ser Pro Asn Pro Glu Asp Gly 
                645                 650                 655     
Ile Val Arg Ala His Met Glu Asp Ser Cys Pro Gln Phe Leu Gly Pro 
            660                 665                 670         
Ser Pro Leu Val Ile Pro Met Asn His Glu Thr Asp Val Asn Phe Gln 
        675                 680                 685             
Gly Lys Asn Leu Asp Thr Val Lys Gly Ser Ser Leu His Val Gly Ser 
    690                 695                 700                 
Asp Leu Leu Lys Phe Met Glu Pro Val Thr Met Gln Glu Ser Gly Thr 
705                 710                 715                 720 
Phe Ala Phe Arg Thr Pro Lys Leu Ser His Asp Ala Asn Glu Thr Leu 
                725                 730                 735     
Pro Leu His Leu Tyr Val Lys Ser Tyr Gly Lys Asn Ile Asp Ser Lys 
            740                 745                 750         
Leu His Val Thr Leu Tyr Asn Cys Ser Phe Gly Arg Ser Asp Cys Ser 
        755                 760                 765             
Leu Cys Arg Ala Ala Asn Pro Asp Tyr Arg Cys Ala Trp Cys Gly Gly 
    770                 775                 780                 
Gln Ser Arg Cys Val Tyr Glu Ala Leu Cys Asn Thr Thr Ser Glu Cys 
785                 790                 795                 800 
Pro Pro Pro Val Ile Thr Arg Ile Gln Pro Glu Thr Gly Pro Leu Gly 
                805                 810                 815     
Gly Gly Ile Arg Ile Thr Ile Leu Gly Ser Asn Leu Gly Val Gln Ala 
            820                 825                 830         
Gly Asp Ile Gln Arg Ile Ser Val Ala Gly Arg Asn Cys Ser Phe Gln 
        835                 840                 845             
Pro Glu Arg Tyr Ser Val Ser Thr Arg Ile Val Cys Val Ile Glu Ala 
    850                 855                 860                 
Ala Glu Thr Pro Phe Thr Gly Gly Val Glu Val Asp Val Phe Gly Lys 
865                 870                 875                 880 
Leu Gly Arg Ser Pro Pro Asn Val Gln Phe Thr Phe Gln Gln Pro Lys 
                885                 890                 895     
Pro Leu Ser Val Glu Pro Gln Gln Gly Pro Gln Ala Gly Gly Thr Thr 
            900                 905                 910         
Leu Thr Ile His Gly Thr His Leu Asp Thr Gly Ser Gln Glu Asp Val 
        915                 920                 925             
Arg Val Thr Leu Asn Gly Val Pro Cys Lys Val Thr Lys Phe Gly Ala 
    930                 935                 940                 
Gln Leu Gln Cys Val Thr Gly Pro Gln Ala Thr Arg Gly Gln Met Leu 
945                 950                 955                 960 
Leu Glu Val Ser Tyr Gly Gly Ser Pro Val Pro Asn Pro Gly Ile Phe 
                965                 970                 975     
Phe Thr Tyr Arg Glu Asn Pro Val Leu Arg Ala Phe Glu Pro Leu Arg 
            980                 985                 990         
Ser Phe Ala Ser Gly Gly Arg Ser Ile Asn Val Thr Gly Gln Gly Phe 
        995                 1000                1005            
Ser Leu Ile Gln Arg Phe Ala Met Val Val Ile Ala Glu Pro Leu Gln 
    1010                1015                1020                
Ser Trp Gln Pro Pro Arg Glu Ala Glu Ser Leu Gln Pro Met Thr Val 
1025                1030                1035                1040
Val Gly Thr Asp Tyr Val Phe His Asn Asp Thr Lys Val Val Phe Leu 
                1045                1050                1055    
Ser Pro Ala Val Pro Glu Glu Pro Glu Ala Tyr Asn Leu Thr Val Leu 
            1060                1065                1070        
Ile Glu Met Asp Gly His Arg Ala Leu Leu Arg Thr Glu Ala Gly Ala 
        1075                1080                1085            
Phe Glu Tyr Val Pro Asp Pro Thr Phe Glu Asn Phe Thr Gly Gly Val 
    1090                1095                1100                
Lys Lys Gln Val Asn Lys Leu Ile His Ala Arg Gly Thr Asn Leu Asn 
1105                1110                1115                1120
Lys Ala Met Thr Leu Gln Glu Ala Glu Ala Phe Val Gly Ala Glu Arg 
                1125                1130                1135    
Cys Thr Met Lys Thr Leu Thr Glu Thr Asp Leu Tyr Cys Glu Pro Pro 
            1140                1145                1150        
Glu Val Gln Pro Pro Pro Lys Arg Arg Gln Lys Arg Asp Thr Thr His 
        1155                1160                1165            
Asn Leu Pro Glu Phe Ile Val Lys Phe Gly Ser Arg Glu Trp Val Leu 
    1170                1175                1180                
Gly Arg Val Glu Tyr Asp Thr Arg Val Ser Asp Val Pro Leu Ser Leu 
1185                1190                1195                1200
Ile Leu Pro Leu Val Ile Val Pro Met Val Val Val Ile Ala Val Ser 
                1205                1210                1215    
Val Tyr Cys Tyr Trp Arg Lys Ser Gln Gln Ala Glu Arg Glu Tyr Glu 
            1220                1225                1230        
Lys Ile Lys Ser Gln Leu Glu Gly Leu Glu Glu Ser Val Arg Asp Arg 
        1235                1240                1245            
Cys Lys Lys Glu Phe Thr Asp Leu Met Ile Glu Met Glu Asp Gln Thr 
    1250                1255                1260                
Asn Asp Val His Glu Ala Gly Ile Pro Val Leu Asp Tyr Lys Thr Tyr 
1265                1270                1275                1280
Thr Asp Arg Val Phe Phe Leu Pro Ser Lys Asp Gly Asp Lys Asp Val 
                1285                1290                1295    
Met Ile Thr Gly Lys Leu Asp Ile Pro Glu Pro Arg Arg Pro Val Val 
            1300                1305                1310        
Glu Gln Ala Leu Tyr Gln Phe Ser Asn Leu Leu Asn Ser Lys Ser Phe 
        1315                1320                1325            
Leu Ile Asn Phe Ile His Thr Leu Glu Asn Gln Arg Glu Phe Ser Ala 
    1330                1335                1340                
Arg Ala Lys Val Tyr Phe Ala Ser Leu Leu Thr Val Ala Leu His Gly 
1345                1350                1355                1360
Lys Leu Glu Tyr Tyr Thr Asp Ile Met His Thr Leu Phe Leu Glu Leu 
                1365                1370                1375    
Leu Glu Gln Tyr Val Val Ala Lys Asn Pro Lys Leu Met Leu Arg Arg 
            1380                1385                1390        
Ser Glu Thr Val Val Glu Arg Met Leu Ser Asn Trp Met Ser Ile Cys 
        1395                1400                1405            
Leu Tyr Gln Tyr Leu Lys Asp Ser Ala Gly Glu Pro Leu Tyr Lys Leu 
    1410                1415                1420                
Phe Lys Ala Ile Lys His Gln Val Glu Lys Gly Pro Val Asp Ala Val 
1425                1430                1435                1440
Gln Lys Lys Ala Lys Tyr Thr Leu Asn Asp Thr Gly Leu Leu Gly Asp 
                1445                1450                1455    
Asp Val Glu Tyr Ala Pro Leu Thr Val Ser Val Ile Val Gln Asp Glu 
            1460                1465                1470        
Gly Val Asp Ala Ile Pro Val Lys Val Leu Asn Cys Asp Thr Ile Ser 
        1475                1480                1485            
Gln Val Lys Glu Lys Ile Ile Asp Gln Val Tyr Arg Gly Gln Pro Cys 
    1490                1495                1500                
Ser Cys Trp Pro Arg Pro Asp Ser Val Val Leu Glu Trp Arg Pro Gly 
1505                1510                1515                1520
Ser Thr Ala Gln Ile Leu Ser Asp Leu Asp Leu Thr Ser Gln Arg Glu 
                1525                1530                1535    
Gly Arg Trp Lys Arg Val Asn Thr Leu Met His Tyr Asn Val Arg Asp 
            1540                1545                1550        
Gly Ala Thr Leu Ile Leu Ser Lys Val Gly Val Ser Gln Gln Pro Glu 
        1555                1560                1565            
Asp Ser Gln Gln Asp Leu Pro Gly Glu Arg His Ala Leu Leu Glu Glu 
    1570                1575                1580                
Glu Asn Arg Val Trp His Leu Val Arg Pro Thr Asp Glu Val Asp Glu 
1585                1590                1595                1600
Gly Lys Ser Lys Arg Gly Ser Val Lys Glu Lys Glu Arg Thr Lys Ala 
                1605                1610                1615    
Ile Thr Glu Ile Tyr Leu Thr Arg Leu Leu Ser Val Lys Gly Thr Leu 
            1620                1625                1630        
Gln Gln Phe Val Asp Asn Phe Phe Gln Ser Val Leu Ala Pro Gly His 
        1635                1640                1645            
Ala Val Pro Pro Ala Val Lys Tyr Phe Phe Asp Phe Leu Asp Glu Gln 
    1650                1655                1660                
Ala Glu Lys His Asn Ile Gln Asp Glu Asp Thr Ile His Ile Trp Lys 
1665                1670                1675                1680
Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys Asn Pro 
                1685                1690                1695    
His Phe Ile Phe Asp Val His Val His Glu Val Val Asp Ala Ser Leu 
            1700                1705                1710        
Ser Val Ile Ala Gln Thr Phe Met Asp Ala Cys Thr Arg Thr Glu His 
        1715                1720                1725            
Lys Leu Ser Arg Asp Ser Pro Ser Asn Lys Leu Leu Tyr Ala Lys Glu 
    1730                1735                1740                
Ile Ser Thr Tyr Lys Lys Met Val Glu Asp Tyr Tyr Lys Gly Ile Arg 
1745                1750                1755                1760
Gln Met Val Gln Val Ser Asp Gln Asp Met Asn Thr His Leu Ala Glu 
                1765                1770                1775    
Ile Ser Arg Ala His Thr Asp Ser Leu Asn Thr Leu Val Ala Leu His 
            1780                1785                1790        
Gln Leu Tyr Gln Tyr Thr Gln Lys Tyr Tyr Asp Glu Ile Ile Asn Ala 
        1795                1800                1805            
Leu Glu Glu Asp Pro Ala Ala Gln Lys Met Gln Leu Ala Phe Arg Leu 
    1810                1815                1820                
Gln Gln Ile Ala Ala Ala Leu Glu Asn Lys Val Thr Asp Leu 
1825                1830                1835            

<210> 5
<211> 5859
<212> DNA
<213> Homo sapiens

<220> 
<223> PLXNB1-204 cDNA (coding sequence)

<400> 5
atgcctgctc tgggcccagc tcttctccag gctctctggg ccgggtgggt cctcaccctc       60

cagccccttc caccaactgc attcactccc aatggcacgt atctgcagca cctggcaagg      120

gaccccacct caggcaccct ctacctgggg gctaccaact tcctgttcca gctgagccct      180

gggctgcagc tggaggccac agtgtccacc ggccctgtgc tagacagcag ggactgcctg      240

ccacctgtga tgcctgatga gtgcccccag gcccagccta ccaacaaccc gaatcagctg      300

ctcctggtga gcccaggggc cctggtggta tgcgggagcg tgcaccaggg ggtctgtgaa      360

cagcggcgcc tggggcagct cgagcagctg ctgctgcggc cagagcggcc tggggacaca      420

caatatgtgg ctgccaatga tcctgcggtc agcacggtgg ggctggtagc ccagggcttg      480

gcaggggagc ccctcctgtt tgtggggcga ggatacacca gcaggggtgt ggggggtggc      540

attccaccca tcacaacccg ggccctgtgg ccgcccgacc cccaagctgc cttctcctat      600

gaggagacag ccaagctggc agtgggccgc ctctccgagt acagccacca cttcgtgagt      660

gcctttgcac gtggggccag cgcctacttc ctgttcctgc ggcgggacct gcaggctcag      720

tctagagctt ttcgtgccta tgtatctcga gtgtgtctcc gggaccagca ctactactcc      780

tatgtggagt tgcctctggc ctgcgaaggt ggccgctacg ggctgatcca ggctgcagct      840

gtggccacgt ccagggaggt ggcgcatggg gaggtgctct ttgcagcttt ctcctcggct      900

gcacccccca ctgtgggccg gcccccatcg gcggctgctg gggcatctgg agcctctgcc      960

ctctgtgcct tccccctgga tgaggtggac cggcttgcta atcgcacgcg agatgcctgc     1020

tacacccggg agggtcgtgc tgaggatggg accgaggtgg cctacatcga gtatgatgtc     1080

aattctgact gtgcacagct gccagtggac accctggatg cttatccctg tggctcagac     1140

cacacgccca gccccatggc cagccgggtc ccgctggaag ccacaccaat tctggagtgg     1200

ccagggattc agctaacagc tgtggcagtc accatggaag atggacacac catcgctttc     1260

ctgggtgata gtcaagggca gctgcacagg gtctacttgg gcccagggag cgatggccac     1320

ccatactcca cacagagcat ccagcagggg tctgcagtga gcagagacct cacctttgat     1380

gggacctttg agcacctgta tgtcatgacc cagagcacac ttctgaaggt tcctgtggct     1440

tcctgtgctc agcacctgga ctgtgcatct tgccttgctc acagggaccc atactgtggg     1500

tggtgcgtgc tccttggcag gtgcagtcgc cgttctgagt gctcgagggg ccagggccca     1560

gagcagtggc tatggagctt ccagcctgag ctgggctgtc tgcaagtggc agccatgagt     1620

cctgccaaca tcagccgaga ggagacgagg gaggttttcc tatcagtgcc agacctgcca     1680

cccctgtggc caggggagtc atattcctgc cactttgggg aacatcagag tcctgccctg     1740

ctgactggtt ctggtgtgat gtgcccctcc ccagacccta gtgaggcccc agtgctgccg     1800

agaggagccg actacgtatc cgtgagcgtg gagctcagat ttggcgctgt tgtgatcgcc     1860

aaaacttccc tctctttcta tgactgtgtg gcggtcactg aactccgccc atctgcgcag     1920

tgccaggcct gtgtgagcag ccgctggggg tgtaactggt gtgtctggca gcacctgtgc     1980

acccacaagg cctcgtgtga tgctgggccc atggttgcaa gccatcagag cccgcttgtc     2040

tccccagacc ctcctgcaag aggtgatgga gactcagcag agcttgaggg ccctcccgcc     2100

cccctcatcc tcccgtccag cctcgactac cagtatgaca cccccgggct ctgggagctg     2160

gaagaggcga ccttgggggc aagctcctgc ccctgtgtgg agagcgttca gggctccacg     2220

ttgatgccgg tccatgtgga gcgggaaatc cggctgctag gcaggaacct gcaccttttc     2280

caggatggcc caggagacaa tgagtgtgtg atggagctgg agggcctcga ggtggtggtt     2340

gaggcccggg tcgagtgtga gccacctcca gatacccagt gccatgtcac ctgccagcag     2400

caccagctca gctatgaggc tctgcagccg gagctccgtg tggggctgtt tctgcgtcgg     2460

gccggccgtc tgcgtgtgga cagtgctgag gggctgcatg tggtactgta tgactgttcc     2520

gtgggacatg gagactgcag ccgctgccaa actgccatgc cccagtatgg ctgtgtgtgg     2580

tgtgaggggg agcgtccacg ttgtgtgacc cgggaggcct gtggtgaggc tgaggctgtg     2640

gccacccagt gcccagcgcc cctcatccac tcggtggagc cactgactgg gcctgtagac     2700

ggaggcaccc gtgtcaccat caggggctcc aacctgggcc agcatgtgca ggatgtgctg     2760

ggcatggtca cggtggctgg agtgccctgt gctgtggatg cccaggagta cgaggtctcc     2820

agcagcctcg tgtgcatcac cggggccagt ggggaggagg tggccggcgc cacagcggtg     2880

gaggtgccgg gaagaggacg tggtgtctca gaacacgact ttgcctacca ggatccgaag     2940

gtccattcca tcttcccggc ccgcggcccc agagctgggg gcacccgtct caccctgaat     3000

ggctccaagc tcctgactgg gcggctggag gacatccgag tggtggttgg agaccagcct     3060

tgtcacttgc tgccggagca gcagtcagaa caactgcggt gtgagaccag cccacgcccc     3120

acgcctgcca cgctccctgt ggctgtgtgg tttggggcca cggagcggag gcttcaacgc     3180

ggacagttca agtatacctt ggaccccaac atcacctctg ctggccccac caagagcttc     3240

ctcagtggag gacgtgagat atgcgtccgt ggccagaatc tggacgtggt acagacgcca     3300

agaatccggg tgaccgtggt ctcgagaatg ctgcagccca gccaggggct tggacggagg     3360

cgtcgcgtgg tcccggagac ggcatgttcc cttggaccct cctgcagtag ccagcaattt     3420

gaggagccgt gccatgtcaa ctcctcccag ctcatcacgt gccgcacacc tgccctccca     3480

ggcctgcctg aggacccctg ggtccgggtg gaatttatcc ttgacaacct ggtctttgac     3540

tttgcaacac tgaaccccac acctttctcc tatgaggccg accccaccct gcagccactc     3600

aaccctgagg accccaccat gccattccgg cacaagcctg ggagtgtgtt ctccgtggag     3660

ggggagaacc tggaccttgc aatgtccaag gaggaggtgg tggctatgat aggggatggc     3720

ccctgtgtgg tgaagacgct gacgcggcac cacctgtact gcgagccccc cgtggagcag     3780

cccctgccac ggcaccatgc cctccgagag gcacctgact ctttgcctga gttcacggtg     3840

cagatgggga acttgcgctt ctccctgggt cacgtgcagt atgacggcga gagccctggg     3900

gcttttcctg tggcagccca ggtgggcttg ggggtgggca cctctcttct ggctctgggt     3960

gtcatcatca ttgtcctcat gtacaggagg aagagcaagc aggccctgag ggactataag     4020

aaggttcaga tccagctgga gaatctggag agcagtgtgc gggaccgctg caagaaggaa     4080

ttcacagacc tcatgactga gatgaccgat ctcaccagtg acctcctggg cagcggcatc     4140

cccttcctcg actacaaggt gtatgcggag aggatcttct tccctgggca ccgcgagtcg     4200

cccttgcacc gggacctggg tgtgcctgag agcagacggc ccactgtgga gcaagggctg     4260

gggcagctct ctaacctgct caacagcaag ctcttcctca ccaagttcat ccacacgctg     4320

gagagccagc gcaccttttc agctcgggac cgtgcctacg tggcatctct gctcaccgtg     4380

gcactgcatg ggaagcttga gtatttcact gacatcctcc gcactctgct cagtgacctg     4440

gttgcccagt atgtggccaa gaaccccaag ctgatgctgc gcaggacaga gactgtggtg     4500

gagaagctgc tcaccaactg gatgtccatc tgtctgtata ccttcgtgag ggactccgta     4560

ggggagcctc tgtacatgct ctttcgaggg attaagcacc aagtggataa ggggccagtg     4620

gacagtgtga caggcaaggc caaatacacc ttgaacgaca accgcctgct cagagaggat     4680

gtggagtacc gtcccctgac cttgaatgca ctattggctg tggggcctgg ggcaggagag     4740

gcccagggcg tgcccgtgaa ggtcctagac tgtgacacca tctcccaggc aaaggagaag     4800

atgctggacc agctttataa aggagtgcct ctcacccagc ggccagaccc tcgcaccctt     4860

gatgttgagt ggcggtctgg ggtggccggg cacctcattc tttctgacga ggatgtcact     4920

tctgaggtcc agggtctgtg gaggcgcctg aacacactgc agcattacaa ggtcccagat     4980

ggagcaactg tggccctcgt cccctgcctc accaagcatg tgctccggga aaaccaggat     5040

tatgtccctg gagagcggac cccaatgctg gaggatgtag atgagggggg catccggccc     5100

tggcacctgg tgaagccaag tgatgagccg gagccgccca ggcctcggag gggcagcctt     5160

cggggcgggg agcgtgagcg cgccaaggcc atccctgaga tctacctgac ccgcctgctg     5220

tccatgaagg gcaccctgca gaagttcgtg gatgacctgt tccaggtgat tctcagcacc     5280

agccgccccg tgccgctcgc tgtgaagtac ttctttgacc tgctggatga gcaggcccag     5340

cagcatggca tctccgacca ggacaccatc cacatctgga agaccaacag cttgcctctg     5400

aggttctgga tcaatataat aaaaaacccg cagtttgtgt tcgacgtgca aacatctgat     5460

aacatggatg cggtgctcct tgtcattgca cagaccttca tggacgcctg caccctggcc     5520

gaccacaagc tgggccggga ctccccgatc aacaaacttc tgtatgcacg ggacattccc     5580

cggtacaagc ggatggtgga aaggtactat gcagacatca gacagactgt cccagccagc     5640

gaccaagaga tgaactctgt cctggctgaa ctgtcctgga actactccgg agacctcggg     5700

gcgcgagtgg ccctgcatga actctacaag tacatcaaca agtactatga ccagatcatc     5760

actgccctgg aggaggatgg cacggcccag aagatgcagc tgggctatcg gctccagcag     5820

attgcagctg ctgtggaaaa caaggtcaca gatctatag                            5859


<210> 6
<211> 1952
<212> PRT
<213> Homo sapiens

<220> 
<223> PLXNB1-204 protein

<400> 6
Met Pro Ala Leu Gly Pro Ala Leu Leu Gln Ala Leu Trp Ala Gly Trp 
1               5                   10                  15      
Val Leu Thr Leu Gln Pro Leu Pro Pro Thr Ala Phe Thr Pro Asn Gly 
            20                  25                  30          
Thr Tyr Leu Gln His Leu Ala Arg Asp Pro Thr Ser Gly Thr Leu Tyr 
        35                  40                  45              
Leu Gly Ala Thr Asn Phe Leu Phe Gln Leu Ser Pro Gly Leu Gln Leu 
    50                  55                  60                  
Glu Ala Thr Val Ser Thr Gly Pro Val Leu Asp Ser Arg Asp Cys Leu 
65                  70                  75                  80  
Pro Pro Val Met Pro Asp Glu Cys Pro Gln Ala Gln Pro Thr Asn Asn 
                85                  90                  95      
Pro Asn Gln Leu Leu Leu Val Ser Pro Gly Ala Leu Val Val Cys Gly 
            100                 105                 110         
Ser Val His Gln Gly Val Cys Glu Gln Arg Arg Leu Gly Gln Leu Glu 
        115                 120                 125             
Gln Leu Leu Leu Arg Pro Glu Arg Pro Gly Asp Thr Gln Tyr Val Ala 
    130                 135                 140                 
Ala Asn Asp Pro Ala Val Ser Thr Val Gly Leu Val Ala Gln Gly Leu 
145                 150                 155                 160 
Ala Gly Glu Pro Leu Leu Phe Val Gly Arg Gly Tyr Thr Ser Arg Gly 
                165                 170                 175     
Val Gly Gly Gly Ile Pro Pro Ile Thr Thr Arg Ala Leu Trp Pro Pro 
            180                 185                 190         
Asp Pro Gln Ala Ala Phe Ser Tyr Glu Glu Thr Ala Lys Leu Ala Val 
        195                 200                 205             
Gly Arg Leu Ser Glu Tyr Ser His His Phe Val Ser Ala Phe Ala Arg 
    210                 215                 220                 
Gly Ala Ser Ala Tyr Phe Leu Phe Leu Arg Arg Asp Leu Gln Ala Gln 
225                 230                 235                 240 
Ser Arg Ala Phe Arg Ala Tyr Val Ser Arg Val Cys Leu Arg Asp Gln 
                245                 250                 255     
His Tyr Tyr Ser Tyr Val Glu Leu Pro Leu Ala Cys Glu Gly Gly Arg 
            260                 265                 270         
Tyr Gly Leu Ile Gln Ala Ala Ala Val Ala Thr Ser Arg Glu Val Ala 
        275                 280                 285             
His Gly Glu Val Leu Phe Ala Ala Phe Ser Ser Ala Ala Pro Pro Thr 
    290                 295                 300                 
Val Gly Arg Pro Pro Ser Ala Ala Ala Gly Ala Ser Gly Ala Ser Ala 
305                 310                 315                 320 
Leu Cys Ala Phe Pro Leu Asp Glu Val Asp Arg Leu Ala Asn Arg Thr 
                325                 330                 335     
Arg Asp Ala Cys Tyr Thr Arg Glu Gly Arg Ala Glu Asp Gly Thr Glu 
            340                 345                 350         
Val Ala Tyr Ile Glu Tyr Asp Val Asn Ser Asp Cys Ala Gln Leu Pro 
        355                 360                 365             
Val Asp Thr Leu Asp Ala Tyr Pro Cys Gly Ser Asp His Thr Pro Ser 
    370                 375                 380                 
Pro Met Ala Ser Arg Val Pro Leu Glu Ala Thr Pro Ile Leu Glu Trp 
385                 390                 395                 400 
Pro Gly Ile Gln Leu Thr Ala Val Ala Val Thr Met Glu Asp Gly His 
                405                 410                 415     
Thr Ile Ala Phe Leu Gly Asp Ser Gln Gly Gln Leu His Arg Val Tyr 
            420                 425                 430         
Leu Gly Pro Gly Ser Asp Gly His Pro Tyr Ser Thr Gln Ser Ile Gln 
        435                 440                 445             
Gln Gly Ser Ala Val Ser Arg Asp Leu Thr Phe Asp Gly Thr Phe Glu 
    450                 455                 460                 
His Leu Tyr Val Met Thr Gln Ser Thr Leu Leu Lys Val Pro Val Ala 
465                 470                 475                 480 
Ser Cys Ala Gln His Leu Asp Cys Ala Ser Cys Leu Ala His Arg Asp 
                485                 490                 495     
Pro Tyr Cys Gly Trp Cys Val Leu Leu Gly Arg Cys Ser Arg Arg Ser 
            500                 505                 510         
Glu Cys Ser Arg Gly Gln Gly Pro Glu Gln Trp Leu Trp Ser Phe Gln 
        515                 520                 525             
Pro Glu Leu Gly Cys Leu Gln Val Ala Ala Met Ser Pro Ala Asn Ile 
    530                 535                 540                 
Ser Arg Glu Glu Thr Arg Glu Val Phe Leu Ser Val Pro Asp Leu Pro 
545                 550                 555                 560 
Pro Leu Trp Pro Gly Glu Ser Tyr Ser Cys His Phe Gly Glu His Gln 
                565                 570                 575     
Ser Pro Ala Leu Leu Thr Gly Ser Gly Val Met Cys Pro Ser Pro Asp 
            580                 585                 590         
Pro Ser Glu Ala Pro Val Leu Pro Arg Gly Ala Asp Tyr Val Ser Val 
        595                 600                 605             
Ser Val Glu Leu Arg Phe Gly Ala Val Val Ile Ala Lys Thr Ser Leu 
    610                 615                 620                 
Ser Phe Tyr Asp Cys Val Ala Val Thr Glu Leu Arg Pro Ser Ala Gln 
625                 630                 635                 640 
Cys Gln Ala Cys Val Ser Ser Arg Trp Gly Cys Asn Trp Cys Val Trp 
                645                 650                 655     
Gln His Leu Cys Thr His Lys Ala Ser Cys Asp Ala Gly Pro Met Val 
            660                 665                 670         
Ala Ser His Gln Ser Pro Leu Val Ser Pro Asp Pro Pro Ala Arg Gly 
        675                 680                 685             
Asp Gly Asp Ser Ala Glu Leu Glu Gly Pro Pro Ala Pro Leu Ile Leu 
    690                 695                 700                 
Pro Ser Ser Leu Asp Tyr Gln Tyr Asp Thr Pro Gly Leu Trp Glu Leu 
705                 710                 715                 720 
Glu Glu Ala Thr Leu Gly Ala Ser Ser Cys Pro Cys Val Glu Ser Val 
                725                 730                 735     
Gln Gly Ser Thr Leu Met Pro Val His Val Glu Arg Glu Ile Arg Leu 
            740                 745                 750         
Leu Gly Arg Asn Leu His Leu Phe Gln Asp Gly Pro Gly Asp Asn Glu 
        755                 760                 765             
Cys Val Met Glu Leu Glu Gly Leu Glu Val Val Val Glu Ala Arg Val 
    770                 775                 780                 
Glu Cys Glu Pro Pro Pro Asp Thr Gln Cys His Val Thr Cys Gln Gln 
785                 790                 795                 800 
His Gln Leu Ser Tyr Glu Ala Leu Gln Pro Glu Leu Arg Val Gly Leu 
                805                 810                 815     
Phe Leu Arg Arg Ala Gly Arg Leu Arg Val Asp Ser Ala Glu Gly Leu 
            820                 825                 830         
His Val Val Leu Tyr Asp Cys Ser Val Gly His Gly Asp Cys Ser Arg 
        835                 840                 845             
Cys Gln Thr Ala Met Pro Gln Tyr Gly Cys Val Trp Cys Glu Gly Glu 
    850                 855                 860                 
Arg Pro Arg Cys Val Thr Arg Glu Ala Cys Gly Glu Ala Glu Ala Val 
865                 870                 875                 880 
Ala Thr Gln Cys Pro Ala Pro Leu Ile His Ser Val Glu Pro Leu Thr 
                885                 890                 895     
Gly Pro Val Asp Gly Gly Thr Arg Val Thr Ile Arg Gly Ser Asn Leu 
            900                 905                 910         
Gly Gln His Val Gln Asp Val Leu Gly Met Val Thr Val Ala Gly Val 
        915                 920                 925             
Pro Cys Ala Val Asp Ala Gln Glu Tyr Glu Val Ser Ser Ser Leu Val 
    930                 935                 940                 
Cys Ile Thr Gly Ala Ser Gly Glu Glu Val Ala Gly Ala Thr Ala Val 
945                 950                 955                 960 
Glu Val Pro Gly Arg Gly Arg Gly Val Ser Glu His Asp Phe Ala Tyr 
                965                 970                 975     
Gln Asp Pro Lys Val His Ser Ile Phe Pro Ala Arg Gly Pro Arg Ala 
            980                 985                 990         
Gly Gly Thr Arg Leu Thr Leu Asn Gly Ser Lys Leu Leu Thr Gly Arg 
        995                 1000                1005            
Leu Glu Asp Ile Arg Val Val Val Gly Asp Gln Pro Cys His Leu Leu 
    1010                1015                1020                
Pro Glu Gln Gln Ser Glu Gln Leu Arg Cys Glu Thr Ser Pro Arg Pro 
1025                1030                1035                1040
Thr Pro Ala Thr Leu Pro Val Ala Val Trp Phe Gly Ala Thr Glu Arg 
                1045                1050                1055    
Arg Leu Gln Arg Gly Gln Phe Lys Tyr Thr Leu Asp Pro Asn Ile Thr 
            1060                1065                1070        
Ser Ala Gly Pro Thr Lys Ser Phe Leu Ser Gly Gly Arg Glu Ile Cys 
        1075                1080                1085            
Val Arg Gly Gln Asn Leu Asp Val Val Gln Thr Pro Arg Ile Arg Val 
    1090                1095                1100                
Thr Val Val Ser Arg Met Leu Gln Pro Ser Gln Gly Leu Gly Arg Arg 
1105                1110                1115                1120
Arg Arg Val Val Pro Glu Thr Ala Cys Ser Leu Gly Pro Ser Cys Ser 
                1125                1130                1135    
Ser Gln Gln Phe Glu Glu Pro Cys His Val Asn Ser Ser Gln Leu Ile 
            1140                1145                1150        
Thr Cys Arg Thr Pro Ala Leu Pro Gly Leu Pro Glu Asp Pro Trp Val 
        1155                1160                1165            
Arg Val Glu Phe Ile Leu Asp Asn Leu Val Phe Asp Phe Ala Thr Leu 
    1170                1175                1180                
Asn Pro Thr Pro Phe Ser Tyr Glu Ala Asp Pro Thr Leu Gln Pro Leu 
1185                1190                1195                1200
Asn Pro Glu Asp Pro Thr Met Pro Phe Arg His Lys Pro Gly Ser Val 
                1205                1210                1215    
Phe Ser Val Glu Gly Glu Asn Leu Asp Leu Ala Met Ser Lys Glu Glu 
            1220                1225                1230        
Val Val Ala Met Ile Gly Asp Gly Pro Cys Val Val Lys Thr Leu Thr 
        1235                1240                1245            
Arg His His Leu Tyr Cys Glu Pro Pro Val Glu Gln Pro Leu Pro Arg 
    1250                1255                1260                
His His Ala Leu Arg Glu Ala Pro Asp Ser Leu Pro Glu Phe Thr Val 
1265                1270                1275                1280
Gln Met Gly Asn Leu Arg Phe Ser Leu Gly His Val Gln Tyr Asp Gly 
                1285                1290                1295    
Glu Ser Pro Gly Ala Phe Pro Val Ala Ala Gln Val Gly Leu Gly Val 
            1300                1305                1310        
Gly Thr Ser Leu Leu Ala Leu Gly Val Ile Ile Ile Val Leu Met Tyr 
        1315                1320                1325            
Arg Arg Lys Ser Lys Gln Ala Leu Arg Asp Tyr Lys Lys Val Gln Ile 
    1330                1335                1340                
Gln Leu Glu Asn Leu Glu Ser Ser Val Arg Asp Arg Cys Lys Lys Glu 
1345                1350                1355                1360
Phe Thr Asp Leu Met Thr Glu Met Thr Asp Leu Thr Ser Asp Leu Leu 
                1365                1370                1375    
Gly Ser Gly Ile Pro Phe Leu Asp Tyr Lys Val Tyr Ala Glu Arg Ile 
            1380                1385                1390        
Phe Phe Pro Gly His Arg Glu Ser Pro Leu His Arg Asp Leu Gly Val 
        1395                1400                1405            
Pro Glu Ser Arg Arg Pro Thr Val Glu Gln Gly Leu Gly Gln Leu Ser 
    1410                1415                1420                
Asn Leu Leu Asn Ser Lys Leu Phe Leu Thr Lys Phe Ile His Thr Leu 
1425                1430                1435                1440
Glu Ser Gln Arg Thr Phe Ser Ala Arg Asp Arg Ala Tyr Val Ala Ser 
                1445                1450                1455    
Leu Leu Thr Val Ala Leu His Gly Lys Leu Glu Tyr Phe Thr Asp Ile 
            1460                1465                1470        
Leu Arg Thr Leu Leu Ser Asp Leu Val Ala Gln Tyr Val Ala Lys Asn 
        1475                1480                1485            
Pro Lys Leu Met Leu Arg Arg Thr Glu Thr Val Val Glu Lys Leu Leu 
    1490                1495                1500                
Thr Asn Trp Met Ser Ile Cys Leu Tyr Thr Phe Val Arg Asp Ser Val 
1505                1510                1515                1520
Gly Glu Pro Leu Tyr Met Leu Phe Arg Gly Ile Lys His Gln Val Asp 
                1525                1530                1535    
Lys Gly Pro Val Asp Ser Val Thr Gly Lys Ala Lys Tyr Thr Leu Asn 
            1540                1545                1550        
Asp Asn Arg Leu Leu Arg Glu Asp Val Glu Tyr Arg Pro Leu Thr Leu 
        1555                1560                1565            
Asn Ala Leu Leu Ala Val Gly Pro Gly Ala Gly Glu Ala Gln Gly Val 
    1570                1575                1580                
Pro Val Lys Val Leu Asp Cys Asp Thr Ile Ser Gln Ala Lys Glu Lys 
1585                1590                1595                1600
Met Leu Asp Gln Leu Tyr Lys Gly Val Pro Leu Thr Gln Arg Pro Asp 
                1605                1610                1615    
Pro Arg Thr Leu Asp Val Glu Trp Arg Ser Gly Val Ala Gly His Leu 
            1620                1625                1630        
Ile Leu Ser Asp Glu Asp Val Thr Ser Glu Val Gln Gly Leu Trp Arg 
        1635                1640                1645            
Arg Leu Asn Thr Leu Gln His Tyr Lys Val Pro Asp Gly Ala Thr Val 
    1650                1655                1660                
Ala Leu Val Pro Cys Leu Thr Lys His Val Leu Arg Glu Asn Gln Asp 
1665                1670                1675                1680
Tyr Val Pro Gly Glu Arg Thr Pro Met Leu Glu Asp Val Asp Glu Gly 
                1685                1690                1695    
Gly Ile Arg Pro Trp His Leu Val Lys Pro Ser Asp Glu Pro Glu Pro 
            1700                1705                1710        
Pro Arg Pro Arg Arg Gly Ser Leu Arg Gly Gly Glu Arg Glu Arg Ala 
        1715                1720                1725            
Lys Ala Ile Pro Glu Ile Tyr Leu Thr Arg Leu Leu Ser Met Lys Gly 
    1730                1735                1740                
Thr Leu Gln Lys Phe Val Asp Asp Leu Phe Gln Val Ile Leu Ser Thr 
1745                1750                1755                1760
Ser Arg Pro Val Pro Leu Ala Val Lys Tyr Phe Phe Asp Leu Leu Asp 
                1765                1770                1775    
Glu Gln Ala Gln Gln His Gly Ile Ser Asp Gln Asp Thr Ile His Ile 
            1780                1785                1790        
Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Ile Asn Ile Ile Lys 
        1795                1800                1805            
Asn Pro Gln Phe Val Phe Asp Val Gln Thr Ser Asp Asn Met Asp Ala 
    1810                1815                1820                
Val Leu Leu Val Ile Ala Gln Thr Phe Met Asp Ala Cys Thr Leu Ala 
1825                1830                1835                1840
Asp His Lys Leu Gly Arg Asp Ser Pro Ile Asn Lys Leu Leu Tyr Ala 
                1845                1850                1855    
Arg Asp Ile Pro Arg Tyr Lys Arg Met Val Glu Arg Tyr Tyr Ala Asp 
            1860                1865                1870        
Ile Arg Gln Thr Val Pro Ala Ser Asp Gln Glu Met Asn Ser Val Leu 
        1875                1880                1885            
Ala Glu Leu Ser Trp Asn Tyr Ser Gly Asp Leu Gly Ala Arg Val Ala 
    1890                1895                1900                
Leu His Glu Leu Tyr Lys Tyr Ile Asn Lys Tyr Tyr Asp Gln Ile Ile 
1905                1910                1915                1920
Thr Ala Leu Glu Glu Asp Gly Thr Ala Gln Lys Met Gln Leu Gly Tyr 
                1925                1930                1935    
Arg Leu Gln Gln Ile Ala Ala Ala Val Glu Asn Lys Val Thr Asp Leu 
            1940                1945                1950        



<210> 7
<211> 704
<212> DNA
<213> Homo sapiens

<220> 
<223> PLXNB2-202 cDNA (coding sequence)

<400> 7
tacaagccct tccacggcga tatccagtgc ggcggccacg cgccgggctc cagcaagagc      60

ttcccatgtg gctcggagca cctgccctac ccgctgggca gccgcgacgg gctcagaggc     120

acagccgtgc tgcagcgtgg aggcctgaac ctcacggccg tgacggtcgc cgccgagaac     180

aaccacactg ttgcttttct ggagtggcgt ccgggctcca cagcgcagat cctgtcggac     240

ctggacctga cgtcacagcg ggagggccgg tggaagcgcg tcaacaccct tatgcactac     300

aatgtccggg atggagccac cctcatcctg tccaaggtgg gggtctccca gcagccggag     360

gacagccagc aggacctgcc tggggagcgc catgccctcc tggaggagga gaaccgggtg     420

tggcacctgg tgcggccgac cgacgaggtg gacgagggca agtccaagag aggcagcgtg     480

aaagagaagg agcggacgaa ggccatcacc gagatctacc tgacgcggct gctctcagtc     540

aagggcacac tgcagcagtt tgtggacaac ttcttccaga gcgtgctggc gcctgggcac     600

gcggtgccac ctgcagtcaa gtacttcttc gacttcctgg acgagcaggc agagaagcac     660

aacatccagg atgaagacac catccacatc tggaagacga acag                      704


<210> 8
<211> 234
<212> PRT
<213> Homo sapiens

<220> 
<223> PLXNB2-202 protein

<400> 8
Tyr Lys Pro Phe His Gly Asp Ile Gln Cys Gly Gly His Ala Pro Gly 
1               5                   10                  15      
Ser Ser Lys Ser Phe Pro Cys Gly Ser Glu His Leu Pro Tyr Pro Leu 
            20                  25                  30          
Gly Ser Arg Asp Gly Leu Arg Gly Thr Ala Val Leu Gln Arg Gly Gly 
        35                  40                  45              
Leu Asn Leu Thr Ala Val Thr Val Ala Ala Glu Asn Asn His Thr Val 
    50                  55                  60                  
Ala Phe Leu Glu Trp Arg Pro Gly Ser Thr Ala Gln Ile Leu Ser Asp 
65                  70                  75                  80  
Leu Asp Leu Thr Ser Gln Arg Glu Gly Arg Trp Lys Arg Val Asn Thr 
                85                  90                  95      
Leu Met His Tyr Asn Val Arg Asp Gly Ala Thr Leu Ile Leu Ser Lys 
            100                 105                 110         
Val Gly Val Ser Gln Gln Pro Glu Asp Ser Gln Gln Asp Leu Pro Gly 
        115                 120                 125             
Glu Arg His Ala Leu Leu Glu Glu Glu Asn Arg Val Trp His Leu Val 
    130                 135                 140                 
Arg Pro Thr Asp Glu Val Asp Glu Gly Lys Ser Lys Arg Gly Ser Val 
145                 150                 155                 160 
Lys Glu Lys Glu Arg Thr Lys Ala Ile Thr Glu Ile Tyr Leu Thr Arg 
                165                 170                 175     
Leu Leu Ser Val Lys Gly Thr Leu Gln Gln Phe Val Asp Asn Phe Phe 
            180                 185                 190         
Gln Ser Val Leu Ala Pro Gly His Ala Val Pro Pro Ala Val Lys Tyr 
        195                 200                 205             
Phe Phe Asp Phe Leu Asp Glu Gln Ala Glu Lys His Asn Ile Gln Asp 
    210                 215                 220                 
Glu Asp Thr Ile His Ile Trp Lys Thr Asn 
225                 230                 

<210> 9
<211> 485
<212> DNA
<213> Homo sapiens

<220> 
<223> PLXNB2-203 cDNA (coding sequence)

<400> 9
atggcactgc agctctgggc cctgaccctg ctgggcctgc tgggcgcagg tgccagcctg      60

aggccccgca agctggactt cttccgcagc gagaaagagc tgaaccacct ggctgtggat     120

gaggcctcag gcgtggtgta cctgggggcg gtgaatgccc tctaccagct ggatgcgaag     180

ctgcagctgg agcagcaggt ggccacgggc ccggccctgg acaacaagaa gtgcacgccg     240

cccatcgagg ccagccagtg ccatgaggct gagatgactg acaatgtcaa ccagctgctg     300

ctgctcgacc ctcccaggaa gcgcctggtg gagtgcggca gcctcttcaa gggcatctgc     360

gctctgcgcg ccctgagcaa catctccctc cgcctgttct acgaggacgg cagcggggag     420

aagtctttcg tggccagcaa tgatgagggc gtggccacag tggggctggt gagctccacg     480

ggtcc                                                                 485


<210> 10
<211> 161
<212> PRT
<213> Homo sapiens

<220> 
<223> PLXNB2-203 protein

<400> 10
Met Ala Leu Gln Leu Trp Ala Leu Thr Leu Leu Gly Leu Leu Gly Ala 
1               5                   10                  15      
Gly Ala Ser Leu Arg Pro Arg Lys Leu Asp Phe Phe Arg Ser Glu Lys 
            20                  25                  30          
Glu Leu Asn His Leu Ala Val Asp Glu Ala Ser Gly Val Val Tyr Leu 
        35                  40                  45              
Gly Ala Val Asn Ala Leu Tyr Gln Leu Asp Ala Lys Leu Gln Leu Glu 
    50                  55                  60                  
Gln Gln Val Ala Thr Gly Pro Ala Leu Asp Asn Lys Lys Cys Thr Pro 
65                  70                  75                  80  
Pro Ile Glu Ala Ser Gln Cys His Glu Ala Glu Met Thr Asp Asn Val 
                85                  90                  95      
Asn Gln Leu Leu Leu Leu Asp Pro Pro Arg Lys Arg Leu Val Glu Cys 
            100                 105                 110         
Gly Ser Leu Phe Lys Gly Ile Cys Ala Leu Arg Ala Leu Ser Asn Ile 
        115                 120                 125             
Ser Leu Arg Leu Phe Tyr Glu Asp Gly Ser Gly Glu Lys Ser Phe Val 
    130                 135                 140                 
Ala Ser Asn Asp Glu Gly Val Ala Thr Val Gly Leu Val Ser Ser Thr 
145                 150                 155                 160 
Gly 
    

<210> 11
<211> 568
<212> DNA
<213> Homo sapiens

<220> 
<223> PLXNB2-204 cDNA (coding sequence)

<220> 
<221> variation
<222> 1
<223> /replace="a,c,g,t"

<400> 11
nacgaagttt ggggcgcagc tccagtgtgt cactggcccc caggcgacac ggggccagat      60

gcttctggag gtctcctacg gggggtcccc cgtgcccaac cccggcatct tcttcaccta     120

ccgcgaaaac cccgtactgc gagccttcga gccgctacga agctttgcca ggtggtgggt     180

acagactacg tgttccacaa tgacaccaag gtcgtcttcc tgtccccggc tgtgcctgag     240

gagccagagg cctacaacct cacggtgctg atcgagatgg acgggcaccg tgccctgctc     300

agaacagagg ccggggcctt cgagtacgtg cctgacccca cctttgagaa cttcacaggt     360

ggcgtcaaga agcaggtcaa caagctcatc cacgcccggg gcaccaatct gaacaaggcg     420

atgacgctgc aggaggccga ggccttcgtg ggtgccgagc gctgcaccat gaagacgctg     480

acggagaccg acctgtactg tgagcccccg gaggtgcagc ccccgcccaa gcggcggcag     540

aaacgagaca ccacacacaa cctgcccg                                        568


<210> 12
<211> 189
<212> PRT
<213> Homo sapiens

<220> 
<223> PLXNB2-204 protein

<220> 
<221> VARIANT
<222> 1
<223> Ala,Cys,Asp,Glu,Phe,Gly,His,Ile,Lys,Leu,Met,Asn,Pro,Gln,Arg,Ser,T
      hr,Val,Trp,Tyr

<400> 12
Xaa Glu Val Trp Gly Ala Ala Pro Val Cys His Trp Pro Pro Gly Asp 
1               5                   10                  15      
Thr Gly Pro Asp Ala Ser Gly Gly Leu Leu Arg Gly Val Pro Arg Ala 
            20                  25                  30          
Gln Pro Arg His Leu Leu His Leu Pro Arg Lys Pro Arg Thr Ala Ser 
        35                  40                  45              
Leu Arg Ala Ala Thr Lys Leu Cys Gln Val Val Gly Thr Asp Tyr Val 
    50                  55                  60                  
Phe His Asn Asp Thr Lys Val Val Phe Leu Ser Pro Ala Val Pro Glu 
65                  70                  75                  80  
Glu Pro Glu Ala Tyr Asn Leu Thr Val Leu Ile Glu Met Asp Gly His 
                85                  90                  95      
Arg Ala Leu Leu Arg Thr Glu Ala Gly Ala Phe Glu Tyr Val Pro Asp 
            100                 105                 110         
Pro Thr Phe Glu Asn Phe Thr Gly Gly Val Lys Lys Gln Val Asn Lys 
        115                 120                 125             
Leu Ile His Ala Arg Gly Thr Asn Leu Asn Lys Ala Met Thr Leu Gln 
    130                 135                 140                 
Glu Ala Glu Ala Phe Val Gly Ala Glu Arg Cys Thr Met Lys Thr Leu 
145                 150                 155                 160 
Thr Glu Thr Asp Leu Tyr Cys Glu Pro Pro Glu Val Gln Pro Pro Pro 
                165                 170                 175     
Lys Arg Arg Gln Lys Arg Asp Thr Thr His Asn Leu Pro 
            180                 185                 

<210> 13
<211> 1431
<212> DNA
<213> Homo sapiens

<220> 
<223> PLXNB2-205 cDNA (coding sequence

<400> 13
atggcactgc agctctgggc cctgaccctg ctgggcctgc tgggcgcagg tgccagcctg      60

aggccccgca agctggactt cttccgcagc gagaaagagc tgaaccacct ggctgtggat     120

gaggcctcag gcgtggtgta cctgggggcg gtgaatgccc tctaccagct ggatgcgaag     180

ctgcagctgg agcagcaggt ggccacgggc ccggccctgg acaacaagaa gtgcacgccg     240

cccatcgagg ccagccagtg ccatgaggct gagatgactg acaatgtcaa ccagctgctg     300

ctgctcgacc ctcccaggaa gcgcctggtg gagtgcggca gcctcttcaa gggcatctgc     360

gctctgcgcg ccctgagcaa catctccctc cgcctgttct acgaggacgg cagcggggag     420

aagtctttcg tggccagcaa tgatgagggc gtggccacag tggggctggt gagctccacg     480

ggtcctggtg gtgaccgcgt gctgtttgtg ggcaaaggca atgggccaca cgacaacggc     540

atcatcgtga gcactcggct gttggaccgg actgacagca gggaggcctt tgaagcctac     600

acggaccacg ccacctacaa ggccggctac ctgtccacca acacacagca gttcgtggcg     660

gccttcgagg acggccccta cgtcttcttt gtcttcaacc agcaggacaa gcacccggcc     720

cggaaccgca cgctgctggc acgcatgtgc agagaagacc ccaactacta ctcctacctg     780

gagatggacc tgcagtgccg ggaccccgac atccacgccg ctgcctttgg cacctgcctg     840

gccgcctccg tggctgcgcc tggctctggc agggtgctat atgctgtctt cagcagagac     900

agccggagca gtggggggcc cggtgcgggc ctctgcctgt tcccgctgga caaggtgcac     960

gccaagatgg aggccaaccg caacgcctgt tacacaggca cccgggaggc ccgtgacatc    1020

ttctacaagc ccttccacgg cgatatccag tgcggcggcc acgcgccggg ctccagcaag    1080

agcttcccat gtggctcgga gcacctgccc tacccgctgg gcagccgcga cgggctcaga    1140

ggcacagccg tgctgcagcg tggaggcctg aacctcacgg ccgtgacggt cgccgccgag    1200

aacaaccaca ctgttgcttt tctgggcacc tctgatggcc ggatcctcaa ggtgtacctc    1260

accccagatg gcacctcctc agagtacgac tctatccttg tggagataaa caagagagtc    1320

aagcgcgacc tggtactgtc tggagacctg ggcagcctgt acgccatgac ccaggacaag    1380

gtgttccggc tgccggtgca ggagtgcctg agctacccga cctgcaccca g             1431


<210> 14
<211> 477
<212> PRT
<213> Homo sapiens

<220> 
<223> PLXNB2-205 protein

<400> 14
Met Ala Leu Gln Leu Trp Ala Leu Thr Leu Leu Gly Leu Leu Gly Ala 
1               5                   10                  15      
Gly Ala Ser Leu Arg Pro Arg Lys Leu Asp Phe Phe Arg Ser Glu Lys 
            20                  25                  30          
Glu Leu Asn His Leu Ala Val Asp Glu Ala Ser Gly Val Val Tyr Leu 
        35                  40                  45              
Gly Ala Val Asn Ala Leu Tyr Gln Leu Asp Ala Lys Leu Gln Leu Glu 
    50                  55                  60                  
Gln Gln Val Ala Thr Gly Pro Ala Leu Asp Asn Lys Lys Cys Thr Pro 
65                  70                  75                  80  
Pro Ile Glu Ala Ser Gln Cys His Glu Ala Glu Met Thr Asp Asn Val 
                85                  90                  95      
Asn Gln Leu Leu Leu Leu Asp Pro Pro Arg Lys Arg Leu Val Glu Cys 
            100                 105                 110         
Gly Ser Leu Phe Lys Gly Ile Cys Ala Leu Arg Ala Leu Ser Asn Ile 
        115                 120                 125             
Ser Leu Arg Leu Phe Tyr Glu Asp Gly Ser Gly Glu Lys Ser Phe Val 
    130                 135                 140                 
Ala Ser Asn Asp Glu Gly Val Ala Thr Val Gly Leu Val Ser Ser Thr 
145                 150                 155                 160 
Gly Pro Gly Gly Asp Arg Val Leu Phe Val Gly Lys Gly Asn Gly Pro 
                165                 170                 175     
His Asp Asn Gly Ile Ile Val Ser Thr Arg Leu Leu Asp Arg Thr Asp 
            180                 185                 190         
Ser Arg Glu Ala Phe Glu Ala Tyr Thr Asp His Ala Thr Tyr Lys Ala 
        195                 200                 205             
Gly Tyr Leu Ser Thr Asn Thr Gln Gln Phe Val Ala Ala Phe Glu Asp 
    210                 215                 220                 
Gly Pro Tyr Val Phe Phe Val Phe Asn Gln Gln Asp Lys His Pro Ala 
225                 230                 235                 240 
Arg Asn Arg Thr Leu Leu Ala Arg Met Cys Arg Glu Asp Pro Asn Tyr 
                245                 250                 255     
Tyr Ser Tyr Leu Glu Met Asp Leu Gln Cys Arg Asp Pro Asp Ile His 
            260                 265                 270         
Ala Ala Ala Phe Gly Thr Cys Leu Ala Ala Ser Val Ala Ala Pro Gly 
        275                 280                 285             
Ser Gly Arg Val Leu Tyr Ala Val Phe Ser Arg Asp Ser Arg Ser Ser 
    290                 295                 300                 
Gly Gly Pro Gly Ala Gly Leu Cys Leu Phe Pro Leu Asp Lys Val His 
305                 310                 315                 320 
Ala Lys Met Glu Ala Asn Arg Asn Ala Cys Tyr Thr Gly Thr Arg Glu 
                325                 330                 335     
Ala Arg Asp Ile Phe Tyr Lys Pro Phe His Gly Asp Ile Gln Cys Gly 
            340                 345                 350         
Gly His Ala Pro Gly Ser Ser Lys Ser Phe Pro Cys Gly Ser Glu His 
        355                 360                 365             
Leu Pro Tyr Pro Leu Gly Ser Arg Asp Gly Leu Arg Gly Thr Ala Val 
    370                 375                 380                 
Leu Gln Arg Gly Gly Leu Asn Leu Thr Ala Val Thr Val Ala Ala Glu 
385                 390                 395                 400 
Asn Asn His Thr Val Ala Phe Leu Gly Thr Ser Asp Gly Arg Ile Leu 
                405                 410                 415     
Lys Val Tyr Leu Thr Pro Asp Gly Thr Ser Ser Glu Tyr Asp Ser Ile 
            420                 425                 430         
Leu Val Glu Ile Asn Lys Arg Val Lys Arg Asp Leu Val Leu Ser Gly 
        435                 440                 445             
Asp Leu Gly Ser Leu Tyr Ala Met Thr Gln Asp Lys Val Phe Arg Leu 
    450                 455                 460                 
Pro Val Gln Glu Cys Leu Ser Tyr Pro Thr Cys Thr Gln 
465                 470                 475         

<210> 15
<211> 254
<212> DNA
<213> Homo sapiens

<220> 
<223> PLXNB2-206 cDNA (coding sequence)

<220> 
<221> variation
<222> 1
<223> /replace="a,c,g,t"

<400> 15
nagacagatg tgaacttcca gggcaagaac ctggacaccg tgaaggtgtg gatgagtggt     60

ggaggtggcc gtgggaaacc cacagaggac gttcagaggc ttctgcagac acagggttcc    120

tccctgcacg tgggcagtga cttgctcaag ttcatggagc cggtgaccat gcaggaatct    180

gggaccttcg cctttcggac cccaaagctg tcccacgatg ccaacgagac gctgcccctg    240

cacctctacg tcaa                                                      254


<210> 16
<211> 84
<212> PRT
<213> Homo sapiens

<220> 
<223> PLXNB2-206 protein

<220> 
<221> VARIANT
<222> 1
<223> Ala,Cys,Asp,Glu,Phe,Gly,His,Ile,Lys,Leu,Met,Asn,Pro,Gln,Arg,Ser,T
      hr,Val,Trp,Tyr

<400> 16
Xaa Thr Asp Val Asn Phe Gln Gly Lys Asn Leu Asp Thr Val Lys Val 
1               5                   10                  15      
Trp Met Ser Gly Gly Gly Gly Arg Gly Lys Pro Thr Glu Asp Val Gln 
            20                  25                  30          
Arg Leu Leu Gln Thr Gln Gly Ser Ser Leu His Val Gly Ser Asp Leu 
        35                  40                  45              
Leu Lys Phe Met Glu Pro Val Thr Met Gln Glu Ser Gly Thr Phe Ala 
    50                  55                  60                  
Phe Arg Thr Pro Lys Leu Ser His Asp Ala Asn Glu Thr Leu Pro Leu 
65                  70                  75                  80  
His Leu Tyr Val 
                

<210> 17
<211> 483
<212> DNA
<213> Homo sapiens

<220> 
<223> PLXNB2-213 cDNA (coding sequence)

<400> 17
ggacctgacg tcacagcggg agggccggtg gaagcgcgtc aacaccctta tgcactacaa      60

tgtccgggat ggagccaccc tcatcctgtc caaggtgggg gtctcccagc agccggagga     120

cagccagcag gacctgcctg gggagcgcca tgccctcctg gaggaggaga accgggtgtg     180

gcacctggtg cggccgaccg acgaggtgga cgagggcaag tccaagagag gcagcgtgaa     240

agagaaggag cggacgaagg ccatcaccga gatctacctg acgcggctgc tctcagtcaa     300

gggcacactg cagcagtttg tggacaactt cttccagagc gtgctggcct gggcacgcgg     360

tgccacctgc agtcaagtac ttcttcgact tcctggacga gcaggcagag aagcacaaca     420

tccaggatga agacaccatc cacatctgga agacgaacag cttaccgctc cggttctggg     480

tga                                                                   483


<210> 18
<211> 160
<212> PRT
<213> Homo sapiens

<220> 
<223> PLXNB2-213 protein

<400> 18
Gly Pro Asp Val Thr Ala Gly Gly Pro Val Glu Ala Arg Gln His Pro 
1               5                   10                  15      
Tyr Ala Leu Gln Cys Pro Gly Trp Ser His Pro His Pro Val Gln Gly 
            20                  25                  30          
Gly Gly Leu Pro Ala Ala Gly Gly Gln Pro Ala Gly Pro Ala Trp Gly 
        35                  40                  45              
Ala Pro Cys Pro Pro Gly Gly Gly Glu Pro Gly Val Ala Pro Gly Ala 
    50                  55                  60                  
Ala Asp Arg Arg Gly Gly Arg Gly Gln Val Gln Glu Arg Gln Arg Glu 
65                  70                  75                  80  
Arg Glu Gly Ala Asp Glu Gly His His Arg Asp Leu Pro Asp Ala Ala 
                85                  90                  95      
Ala Leu Ser Gln Gly His Thr Ala Ala Val Cys Gly Gln Leu Leu Pro 
            100                 105                 110         
Glu Arg Ala Gly Leu Gly Thr Arg Cys His Leu Gln Ser Ser Thr Ser 
        115                 120                 125             
Ser Thr Ser Trp Thr Ser Arg Gln Arg Ser Thr Thr Ser Arg Met Lys 
    130                 135                 140                 
Thr Pro Ser Thr Ser Gly Arg Arg Thr Ala Tyr Arg Ser Gly Ser Gly 
145                 150                 155                 160 



<210> 19
<211> 1041
<212> DNA
<213> Homo sapiens

<220> 
<223> PLXNB2-214 cDNA (coding sequence)

<400> 19
atgcacacgc tcttcctgga gctcctggag cagtacgtgg tggccaagaa ccccaagctg      60

atgctgcgca ggtctgagac tgtggtggag aggatgctgt ccaactggat gtccatctgc     120

ctgtaccagt acctcaagga cagtgccggg gagcccctgt acaagctctt caaggccatc     180

aaacatcagg tggaaaaggg cccggtggat gcggtacaga agaaggccaa gtacactctc     240

aacgacacgg ggctgctggg ggatgatgtg gagtacgcac ccctgacggt gagcgtgatc     300

gtgcaggacg agggagtgga cgccatcccg gtgaaggtcc tcaactgtga caccatctcc     360

caggtcaagg agaagatcat tgaccaggtg taccgtgggc agccctgctc ctgcggccca     420

ggccagacag cgtggtcctg gagtggcgtc cgggctccac agcgcagatc cgtcggacct     480

ggacctgacg tcacagcggg agggccggtg gaagcgcgtc aacaccctta tgcactacaa     540

tgtccgggat ggagccaccc tcatcctgtc caaggtgggg gtctcccagc agccggagga     600

cagccagcag gacctgcctg gagcgccatg cctcctggag gaggagaacc gggtgtggca     660

cctggtgcgg ccgaccgacg aggtggacga gggcaagtcc aagagaggca gcgtgaaaga     720

gaaggagcgg acgaaggcca tcaccgagat ctacctgacg cggctgctct cagtcaaggg     780

cacactgcag cagtttgtgg acaacttctt ccagagcgtg ctggcgcctg gcacgcggtg     840

ccacctgcag tcaagtactt cttcgacttc ctggacgagc aggcagagaa gcacaacatc     900

caggatgaag acaccatcca catctggaag acgaacagct taccgctccg gttctgggtg     960

aacatcctca agaaccccca cttcatcttt gacgtgcatg tcacgaggtg gtggacgcct    1020

cgctgtcagt catcgcgcag a                                              1041


<210> 20
<211> 347
<212> PRT
<213> Homo sapiens

<220> 
<223> PLXNB2-214 protein

<400> 20
Met His Thr Leu Phe Leu Glu Leu Leu Glu Gln Tyr Val Val Ala Lys 
1               5                   10                  15      
Asn Pro Lys Leu Met Leu Arg Arg Ser Glu Thr Val Val Glu Arg Met 
            20                  25                  30          
Leu Ser Asn Trp Met Ser Ile Cys Leu Tyr Gln Tyr Leu Lys Asp Ser 
        35                  40                  45              
Ala Gly Glu Pro Leu Tyr Lys Leu Phe Lys Ala Ile Lys His Gln Val 
    50                  55                  60                  
Glu Lys Gly Pro Val Asp Ala Val Gln Lys Lys Ala Lys Tyr Thr Leu 
65                  70                  75                  80  
Asn Asp Thr Gly Leu Leu Gly Asp Asp Val Glu Tyr Ala Pro Leu Thr 
                85                  90                  95      
Val Ser Val Ile Val Gln Asp Glu Gly Val Asp Ala Ile Pro Val Lys 
            100                 105                 110         
Val Leu Asn Cys Asp Thr Ile Ser Gln Val Lys Glu Lys Ile Ile Asp 
        115                 120                 125             
Gln Val Tyr Arg Gly Gln Pro Cys Ser Cys Gly Pro Gly Gln Thr Ala 
    130                 135                 140                 
Trp Ser Trp Ser Gly Val Arg Ala Pro Gln Arg Arg Ser Val Gly Pro 
145                 150                 155                 160 
Gly Pro Asp Val Thr Ala Gly Gly Pro Val Glu Ala Arg Gln His Pro 
                165                 170                 175     
Tyr Ala Leu Gln Cys Pro Gly Trp Ser His Pro His Pro Val Gln Gly 
            180                 185                 190         
Gly Gly Leu Pro Ala Ala Gly Gly Gln Pro Ala Gly Pro Ala Trp Ser 
        195                 200                 205             
Ala Met Pro Pro Gly Gly Gly Glu Pro Gly Val Ala Pro Gly Ala Ala 
    210                 215                 220                 
Asp Arg Arg Gly Gly Arg Gly Gln Val Gln Glu Arg Gln Arg Glu Arg 
225                 230                 235                 240 
Glu Gly Ala Asp Glu Gly His His Arg Asp Leu Pro Asp Ala Ala Ala 
                245                 250                 255     
Leu Ser Gln Gly His Thr Ala Ala Val Cys Gly Gln Leu Leu Pro Glu 
            260                 265                 270         
Arg Ala Gly Ala Trp His Ala Val Pro Pro Ala Val Lys Tyr Phe Phe 
        275                 280                 285             
Asp Phe Leu Asp Glu Gln Ala Glu Lys His Asn Ile Gln Asp Glu Asp 
    290                 295                 300                 
Thr Ile His Ile Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val 
305                 310                 315                 320 
Asn Ile Leu Lys Asn Pro His Phe Ile Phe Asp Val His Val Thr Arg 
                325                 330                 335     
Trp Trp Thr Pro Arg Cys Gln Ser Ser Arg Arg 
            340                 345         

