                         SEQUENCE LISTING

<110>  University Health Network
       Brokx, Richard
       Mason, Jacqueline M.
       Bray, Mark R.
 
<120>  FCMR-BINDING MOLECULES AND USES THEREOF

<130>  08945066WO

<150>  US 62/806,237
<151>  2019-02-15

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region (IgG2b)

<400>  1

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Asn Ser Gly Gly Ser Ser Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg His Asn Tyr Asp Ser Ser Tyr Arg Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 


Thr 
145 


<210>  2
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region (IgG2b)

<400>  2

Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Asn Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Arg Ala Asn Gly Leu Val Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Glu Phe Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Phe Lys Arg 
        115                 120                 125             


Ala Asp Ala 
    130     


<210>  3
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region (IgG1)

<400>  3

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Pro Ser Cys Ala Ala Ser Gly Phe Ser Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Asn Ile Gln Tyr Leu 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Val Arg His Asp Asp Gly Ser Ser Tyr Gln Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 


Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
145                 150                 155                 160 


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             


Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
225                 230                 235                 240 


Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
                245                 250                 255     


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
            260                 265                 270         


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
        275                 280                 285             


Gln Gly 
    290 


<210>  4
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region (IgG1)

<400>  4

Met Asp Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Leu Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Asp Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
                165                 170                 175     


Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
        195                 200                 205             


Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
    210                 215                 220                 


Ser Pro 
225     


<210>  5
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region (IgG1)

<400>  5

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Asn Ser Tyr Leu 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg His Asp Asp Gly Ser Arg Tyr Gln Tyr Ile Val 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 


Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
145                 150                 155                 160 


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             


Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
225                 230                 235                 240 


Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
                245                 250                 255     


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
            260                 265                 270         


Leu Thr Pro Lys Val Thr Cys 
        275                 


<210>  6
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region (IgG1)

<400>  6

Met Asp Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Asp Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
                165                 170                 175     


Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
        195                 200                 205             


Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
    210                 215                 220                 


Ser Pro Val Val Asp Ile Ser Lys Asp Asp Gln 
225                 230                 235 


<210>  7
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region (IgG1)

<400>  7

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Val Tyr Pro Asn Asn Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Ala Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Leu Thr Tyr Trp Gly Arg Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
    130                 135                 140                 


Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
                165                 170                 175     


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
            180                 185                 190         


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro 
        195                 200                 205             


Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile 
225                 230                 235                 240 


Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Ile Ser Lys Asp Asp Gln Gly 
        275                 280     


<210>  8
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region (IgG1)

<400>  8

Met Glu Ser Gln Thr Gln Val Leu Ile Ser Leu Leu Phe Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Leu Leu Lys Ser Gly Lys Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Leu Pro Pro Lys Val Leu Ile Tyr Gly Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Ser Pro 
225                 230 


<210>  9
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region (IgG1)

<400>  9

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn His Trp Leu His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Ser Asp Ser Leu Thr His Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Phe Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
    130                 135                 140                 


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
                165                 170                 175     


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
        195                 200                 205             


Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
225                 230                 235                 240 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Ile Ser Lys Asp Asp Gln Gly 
        275                 280         


<210>  10
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region (IgG1)

<400>  10

Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg 
1               5                   10                  15      


Glu Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
            20                  25                  30          


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Trp Gln Gly Thr His Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro 
225             


<210>  11
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region (IgG2b)

<400>  11

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Tyr Pro Asn Asn Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Leu Thr Tyr Trp Gly Pro Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
    130                 135                 140                 


Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly 
                165                 170                 175     


Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly 
            180                 185                 190         


Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro 
        195                 200                 205             


Ser Gln Thr Val Thr Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr 
    210                 215                 220                 


Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 
225                 230                 235                 240 


Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu 
            260                 265                 270         


Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Glu Asp Asp Gln Gly 
    290             


<210>  12
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region (IgG2b)

<400>  12

Met Glu Ser Gln Thr Gln Val Leu Ile Ser Leu Leu Phe Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Gly His Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Val Leu Ile Tyr Gly Ala Val Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Ser Pro 
225                 230 


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR1 (IgG2b)

<400>  13

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR2 (IgG2b)

<400>  14

Ile Asn Ser Gly Gly Ser Ser Ile 
1               5               


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR3 (IgG2b)

<400>  15

Ala Arg His Asn Tyr Asp Ser Ser Tyr Arg Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR1 (IgG2b)

<400>  16

Gln Asp Ile Asn Asn Phe 
1               5       


<210>  17

<400>  17
000

<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR3 (IgG2b)

<400>  18

Leu Gln Tyr Asp Glu Phe Pro Pro Thr 
1               5                   


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR1 (IgG1)

<400>  19

Gly Phe Ser Phe Ser Ser Tyr Gly 
1               5               


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR2 (IgG1)

<400>  20

Ser Ser Gly Gly Ser Asn Ile 
1               5           


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR3 (IgG1)

<400>  21

Val Arg His Asp Asp Gly Ser Ser Tyr Gln Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR1 (IgG1)

<400>  22

Gln Asp Ile Asn Ser Tyr 
1               5       


<210>  23

<400>  23
000

<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR3 (IgG1)

<400>  24

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR1 (IgG1)

<400>  25

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR2 (IgG1)

<400>  26

Ile Ser Ser Gly Gly Thr Tyr Asn 
1               5               


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR3 (IgG1)

<400>  27

Ala Arg His Asp Asp Gly Ser Arg Tyr Gln Tyr Ile Val Asp Tyr 
1               5                   10                  15  


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR1 (IgG1)

<400>  28

Gln Asp Ile Asn Ser Tyr 
1               5       


<210>  29

<400>  29
000

<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR3 (IgG1)

<400>  30

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR1 (IgG1)

<400>  31

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR2 (IgG1)

<400>  32

Val Tyr Pro Asn Asn Gly Gly Thr 
1               5               


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR3 (IgG1)

<400>  33

Ala Arg Gln Leu Thr Tyr 
1               5       


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR1 (IgG1)

<400>  34

Gln Ser Leu Leu Lys Ser Gly Lys Gln Glu Asn Tyr 
1               5                   10          


<210>  35

<400>  35
000

<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR3 (IgG1)

<400>  36

Gln Asn Asp His Ser Tyr Pro Leu Thr 
1               5                   


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR1 (IgG1)

<400>  37

Gly Tyr Thr Phe Thr Asn His Trp 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR2 (IgG1)

<400>  38

Ile Asp Pro Ser Asp Ser Leu Thr 
1               5               


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR3 (IgG1)

<400>  39

Ala Arg Phe Ser Phe Ala Tyr 
1               5           


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR1 (IgG1)

<400>  40

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  41

<400>  41
000

<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR3 (IgG1)

<400>  42

Trp Gln Gly Thr His Leu Trp Thr Phe 
1               5                   


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR1 (IgG2b)

<400>  43

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR2 (IgG2b)

<400>  44

Ile Tyr Pro Asn Asn Gly Gly Thr 
1               5               


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Heavy chain variable region CDR3 (IgG2b)

<400>  45

Ala Arg Gln Leu Thr Tyr 
1               5       


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR1 (IgG2b)

<400>  46

Gln Ser Leu Leu Asn Ser Gly His Gln Glu Asn Tyr 
1               5                   10          


<210>  47

<400>  47
000

<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCMR Light chain variable region CDR3 (IgG2b)

<400>  48

Gln Asn Asp His Ser Tyr Pro Leu Thr 
1               5                   


