                         SEQUENCE LISTING

<110>  Rensselaer Polytechnic Institute
 
<120>  A CONTRACEPTIVE VACCINE BASED ON THE SPERM-ASSOCIATED PROTEIN 
       CATSPER

<130>  104312-201

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  1

Ser Thr Met Glu Phe Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val 
1               5                   10                  15      


Pro Pro Pro Asn Pro Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val 
            20                  25                  30          


Lys Arg Thr Asn Ile Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala 
        35                  40                  45              


Val Gly His Pro Tyr Tyr Ser Ile Lys Lys Val Asn Lys Thr Val Val 
    50                  55                  60                  


Pro Lys Val Ser Gly Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro 
65                  70                  75                  80  


Asp Pro Asn Lys Phe Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr 
                85                  90                  95      


Thr Gln Arg Leu Val Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly 
            100                 105                 110         


Gln Pro Leu Gly Val Gly Val Ser Gly His Pro Leu Leu Asn Lys Tyr 
        115                 120                 125             


Asp Asp Val Glu Asn Ser Gly Gly Tyr Gly Cys Gly Pro Gln Thr Phe 
    130                 135                 140                 


Thr Glu Leu Glu Ile Arg Gly Glu Trp Gly Pro Cys Gly Asn Pro Gly 
145                 150                 155                 160 


Gln Asp Asn Arg Val Asn Val Gly Met Asp Tyr Lys Gln Thr Gln Leu 
                165                 170                 175     


Cys Met Val Gly Cys Ala Pro Pro Leu Gly Glu His Trp Gly Lys Gly 
            180                 185                 190         


Thr Gln Cys Ser Asn Thr Ser Val Gln Asn Gly Asp Cys Pro Pro Leu 
        195                 200                 205             


Glu Leu Ile Thr Ser Val Ile Gln Asp Gly Asp Met Val Asp Thr Gly 
    210                 215                 220                 


Phe Gly Ala Met Asn Phe Ala Asp Leu Gln Thr Asn Lys Ser Asp Val 
225                 230                 235                 240 


Pro Leu Asp Ile Cys Gly Thr Val Cys Lys Tyr Pro Asp Tyr Leu Gln 
                245                 250                 255     


Met Ala Ala Asp Pro Tyr Gly Asp Arg Leu Phe Phe Tyr Leu Arg Lys 
            260                 265                 270         


Glu Gln Met Phe Ala Arg His Phe Phe Asn Arg Ala Gly Thr Val Gly 
        275                 280                 285             


Glu Pro Val Pro Asp Asp Leu Leu Val Lys Gly Gly Asn Asn Arg Ser 
    290                 295                 300                 


Ser Val Ala Ser Ser Ile Tyr Val His Thr Pro Ser Gly Ser Leu Val 
305                 310                 315                 320 


Ser Ser Glu Ala Gln Leu Phe Asn Lys Pro Tyr Trp Leu Gln Lys Ala 
                325                 330                 335     


Gln Gly His Asn Asn Gly Ile Cys Trp Gly Asn His Leu Phe Val Thr 
            340                 345                 350         


Val Val Asp Thr Thr Arg Ser Thr Asn Met Thr Leu Cys Ala Ser Val 
        355                 360                 365             


Ser Lys Ser Ala Thr Tyr Thr Asn Ser Asp Tyr Lys Glu Tyr Met Arg 
    370                 375                 380                 


His Val Glu Glu Phe Asp Leu Gln Phe Ile Phe Gln Leu Cys Ser Ile 
385                 390                 395                 400 


Thr Leu Ser Ala Glu Val Met Ala Tyr Ile His Thr Met Asn Pro Ser 
                405                 410                 415     


Val Leu Glu Asp Trp Asn Phe Gly Leu Ser Pro Pro Pro Asn Gly Thr 
            420                 425                 430         


Leu Glu Asp Thr Tyr Arg Tyr Val Gln Ser Gln Ala Ile Thr Cys Gln 
        435                 440                 445             


Lys Pro Thr Pro Glu Lys Glu Lys Gln Asp Pro Tyr Lys Asp Met Ser 
    450                 455                 460                 


Phe Trp Glu Val Asn Leu Lys Glu Lys Phe Ser Ser Glu Leu Asp Gln 
465                 470                 475                 480 


Phe Pro Leu Gly Arg Lys Phe Leu Leu Gln Ser Gly Tyr Arg Gly Arg 
                485                 490                 495     


Thr Ser Ala Arg Thr Gly Ile 
            500             


<210>  2
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  2

Ser Thr Met Glu Phe Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val 
1               5                   10                  15      


Pro Pro Pro Asn Pro Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val 
            20                  25                  30          


Lys Arg Thr Asn Ile Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala 
        35                  40                  45              


Val Gly His Pro Tyr Tyr Ser Ile Lys Lys Val Asn Lys Thr Val Val 
    50                  55                  60                  


Pro Lys Val Ser Gly Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro 
65                  70                  75                  80  


Asp Pro Asn Lys Phe Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr 
                85                  90                  95      


Thr Gln Arg Leu Val Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly 
            100                 105                 110         


Gln Pro Leu Gly Val Gly Val Ser Gly His Pro Leu Leu Asn Lys Tyr 
        115                 120                 125             


Asp Asp Val Glu Asn Ser Gly Gly Tyr Gly Cys Gly Pro Arg Glu Tyr 
    130                 135                 140                 


Ser Arg Ser Thr Ile Glu Gly Leu Glu Tyr Asn Gly Pro Cys Gly Asn 
145                 150                 155                 160 


Pro Gly Gln Asp Asn Arg Val Asn Val Gly Met Asp Tyr Lys Gln Thr 
                165                 170                 175     


Gln Leu Cys Met Val Gly Cys Ala Pro Pro Leu Gly Glu His Trp Gly 
            180                 185                 190         


Lys Gly Thr Gln Cys Ser Asn Thr Ser Val Gln Asn Gly Asp Cys Pro 
        195                 200                 205             


Pro Leu Glu Leu Ile Thr Ser Val Ile Gln Asp Gly Asp Met Val Asp 
    210                 215                 220                 


Thr Gly Phe Gly Ala Met Asn Phe Ala Asp Leu Gln Thr Asn Lys Ser 
225                 230                 235                 240 


Asp Val Pro Leu Asp Ile Cys Gly Thr Val Cys Lys Tyr Pro Asp Tyr 
                245                 250                 255     


Leu Gln Met Ala Ala Asp Pro Tyr Gly Asp Arg Leu Phe Phe Tyr Leu 
            260                 265                 270         


Arg Lys Glu Gln Met Phe Ala Arg His Phe Phe Asn Arg Ala Gly Thr 
        275                 280                 285             


Val Gly Glu Pro Val Pro Asp Asp Leu Leu Val Lys Gly Gly Asn Asn 
    290                 295                 300                 


Arg Ser Ser Val Ala Ser Ser Ile Tyr Val His Thr Pro Ser Gly Ser 
305                 310                 315                 320 


Leu Val Ser Ser Glu Ala Gln Leu Phe Asn Lys Pro Tyr Trp Leu Gln 
                325                 330                 335     


Lys Ala Gln Gly His Asn Asn Gly Ile Cys Trp Gly Asn His Leu Phe 
            340                 345                 350         


Val Thr Val Val Asp Thr Thr Arg Ser Thr Asn Met Thr Leu Cys Ala 
        355                 360                 365             


Ser Val Ser Lys Ser Ala Thr Tyr Thr Asn Ser Asp Tyr Lys Glu Tyr 
    370                 375                 380                 


Met Arg His Val Glu Glu Phe Asp Leu Gln Phe Ile Phe Gln Leu Cys 
385                 390                 395                 400 


Ser Ile Thr Leu Ser Ala Glu Val Met Ala Tyr Ile His Thr Met Asn 
                405                 410                 415     


Pro Ser Val Leu Glu Asp Trp Asn Phe Gly Leu Ser Pro Pro Pro Asn 
            420                 425                 430         


Gly Thr Leu Glu Asp Thr Tyr Arg Tyr Val Gln Ser Gln Ala Ile Thr 
        435                 440                 445             


Cys Gln Lys Pro Thr Pro Glu Lys Glu Lys Gln Asp Pro Tyr Lys Asp 
    450                 455                 460                 


Met Ser Phe Trp Glu Val Asn Leu Lys Glu Lys Phe Ser Ser Glu Leu 
465                 470                 475                 480 


Asp Gln Phe Pro Leu Gly Arg Lys Phe Leu Leu Gln Ser Gly Tyr Arg 
                485                 490                 495     


Gly Arg Thr Ser Ala Arg Thr Gly Ile 
            500                 505 


<210>  3
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  3

Ser Thr Met Glu Phe Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val 
1               5                   10                  15      


Pro Pro Pro Asn Pro Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val 
            20                  25                  30          


Lys Arg Thr Asn Ile Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala 
        35                  40                  45              


Val Gly His Pro Tyr Tyr Ser Ile Cys Gly Pro Asn Ser Leu Ser Tyr 
    50                  55                  60                  


Ser Phe Tyr Asn His Ser Leu Phe Arg Gly Pro Cys Val Val Pro Lys 
65                  70                  75                  80  


Val Ser Gly Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro Asp Pro 
                85                  90                  95      


Asn Lys Phe Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr Thr Gln 
            100                 105                 110         


Arg Leu Val Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly Gln Pro 
        115                 120                 125             


Leu Gly Val Gly Val Ser Gly His Pro Leu Leu Asn Lys Tyr Asp Asp 
    130                 135                 140                 


Val Glu Asn Ser Gly Gly Tyr Gly Gly Asn Pro Gly Gln Asp Asn Arg 
145                 150                 155                 160 


Val Asn Val Gly Met Asp Tyr Lys Gln Thr Gln Leu Cys Met Val Gly 
                165                 170                 175     


Cys Ala Pro Pro Leu Gly Glu His Trp Gly Lys Gly Thr Gln Cys Ser 
            180                 185                 190         


Asn Thr Ser Val Gln Asn Gly Asp Cys Pro Pro Leu Glu Leu Ile Thr 
        195                 200                 205             


Ser Val Ile Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met 
    210                 215                 220                 


Asn Phe Ala Asp Leu Gln Thr Asn Lys Ser Asp Val Pro Leu Asp Ile 
225                 230                 235                 240 


Cys Gly Thr Val Cys Lys Tyr Pro Asp Tyr Leu Gln Met Ala Ala Asp 
                245                 250                 255     


Pro Tyr Gly Asp Arg Leu Phe Phe Tyr Leu Arg Lys Glu Gln Met Phe 
            260                 265                 270         


Ala Arg His Phe Phe Asn Arg Ala Gly Thr Val Gly Glu Pro Val Pro 
        275                 280                 285             


Asp Asp Leu Leu Val Lys Gly Gly Asn Asn Arg Ser Ser Val Ala Ser 
    290                 295                 300                 


Ser Ile Tyr Val His Thr Pro Ser Gly Ser Leu Val Ser Ser Glu Ala 
305                 310                 315                 320 


Gln Leu Phe Asn Lys Pro Tyr Trp Leu Gln Lys Ala Gln Gly His Asn 
                325                 330                 335     


Asn Gly Ile Cys Trp Gly Asn His Leu Phe Val Thr Val Val Asp Thr 
            340                 345                 350         


Thr Arg Ser Thr Asn Met Thr Leu Cys Ala Ser Val Ser Lys Ser Ala 
        355                 360                 365             


Thr Tyr Thr Asn Ser Asp Tyr Lys Glu Tyr Met Arg His Val Glu Glu 
    370                 375                 380                 


Phe Asp Leu Gln Phe Ile Phe Gln Leu Cys Ser Ile Thr Leu Ser Ala 
385                 390                 395                 400 


Glu Val Met Ala Tyr Ile His Thr Met Asn Pro Ser Val Leu Glu Asp 
                405                 410                 415     


Trp Asn Phe Gly Leu Ser Pro Pro Pro Asn Gly Thr Leu Glu Asp Thr 
            420                 425                 430         


Tyr Arg Tyr Val Gln Ser Gln Ala Ile Thr Cys Gln Lys Pro Thr Pro 
        435                 440                 445             


Glu Lys Glu Lys Gln Asp Pro Tyr Lys Asp Met Ser Phe Trp Glu Val 
    450                 455                 460                 


Asn Leu Lys Glu Lys Phe Ser Ser Glu Leu Asp Gln Phe Pro Leu Gly 
465                 470                 475                 480 


Arg Lys Phe Leu Leu Gln Ser Gly Tyr Arg Gly Arg Thr Ser Ala Arg 
                485                 490                 495     


Thr Gly Ile 
            


<210>  4
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  4

Ser Thr Met Glu Phe Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val 
1               5                   10                  15      


Pro Pro Pro Asn Pro Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val 
            20                  25                  30          


Lys Arg Thr Asn Ile Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala 
        35                  40                  45              


Val Gly His Pro Tyr Tyr Ser Ile Cys Gly Pro Glu Ile Glu Leu Met 
    50                  55                  60                  


Glu Ser Thr Asn Thr Ala Leu Trp Pro Gly Pro Cys Val Val Pro Lys 
65                  70                  75                  80  


Val Ser Gly Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro Asp Pro 
                85                  90                  95      


Asn Lys Phe Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr Thr Gln 
            100                 105                 110         


Arg Leu Val Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly Gln Pro 
        115                 120                 125             


Leu Gly Val Gly Val Ser Gly His Pro Leu Leu Asn Lys Tyr Asp Asp 
    130                 135                 140                 


Val Glu Asn Ser Gly Gly Tyr Gly Gly Asn Pro Gly Gln Asp Asn Arg 
145                 150                 155                 160 


Val Asn Val Gly Met Asp Tyr Lys Gln Thr Gln Leu Cys Met Val Gly 
                165                 170                 175     


Cys Ala Pro Pro Leu Gly Glu His Trp Gly Lys Gly Thr Gln Cys Ser 
            180                 185                 190         


Asn Thr Ser Val Gln Asn Gly Asp Cys Pro Pro Leu Glu Leu Ile Thr 
        195                 200                 205             


Ser Val Ile Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met 
    210                 215                 220                 


Asn Phe Ala Asp Leu Gln Thr Asn Lys Ser Asp Val Pro Leu Asp Ile 
225                 230                 235                 240 


Cys Gly Thr Val Cys Lys Tyr Pro Asp Tyr Leu Gln Met Ala Ala Asp 
                245                 250                 255     


Pro Tyr Gly Asp Arg Leu Phe Phe Tyr Leu Arg Lys Glu Gln Met Phe 
            260                 265                 270         


Ala Arg His Phe Phe Asn Arg Ala Gly Thr Val Gly Glu Pro Val Pro 
        275                 280                 285             


Asp Asp Leu Leu Val Lys Gly Gly Asn Asn Arg Ser Ser Val Ala Ser 
    290                 295                 300                 


Ser Ile Tyr Val His Thr Pro Ser Gly Ser Leu Val Ser Ser Glu Ala 
305                 310                 315                 320 


Gln Leu Phe Asn Lys Pro Tyr Trp Leu Gln Lys Ala Gln Gly His Asn 
                325                 330                 335     


Asn Gly Ile Cys Trp Gly Asn His Leu Phe Val Thr Val Val Asp Thr 
            340                 345                 350         


Thr Arg Ser Thr Asn Met Thr Leu Cys Ala Ser Val Ser Lys Ser Ala 
        355                 360                 365             


Thr Tyr Thr Asn Ser Asp Tyr Lys Glu Tyr Met Arg His Val Glu Glu 
    370                 375                 380                 


Phe Asp Leu Gln Phe Ile Phe Gln Leu Cys Ser Ile Thr Leu Ser Ala 
385                 390                 395                 400 


Glu Val Met Ala Tyr Ile His Thr Met Asn Pro Ser Val Leu Glu Asp 
                405                 410                 415     


Trp Asn Phe Gly Leu Ser Pro Pro Pro Asn Gly Thr Leu Glu Asp Thr 
            420                 425                 430         


Tyr Arg Tyr Val Gln Ser Gln Ala Ile Thr Cys Gln Lys Pro Thr Pro 
        435                 440                 445             


Glu Lys Glu Lys Gln Asp Pro Tyr Lys Asp Met Ser Phe Trp Glu Val 
    450                 455                 460                 


Asn Leu Lys Glu Lys Phe Ser Ser Glu Leu Asp Gln Phe Pro Leu Gly 
465                 470                 475                 480 


Arg Lys Phe Leu Leu Gln Ser Gly Tyr Arg Gly Arg Thr Ser Ala Arg 
                485                 490                 495     


Thr Gly Ile 
            


<210>  5
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  5

Ser Thr Met Glu Phe Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val 
1               5                   10                  15      


Pro Pro Pro Asn Pro Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val 
            20                  25                  30          


Lys Arg Thr Asn Ile Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala 
        35                  40                  45              


Val Gly His Pro Tyr Tyr Ser Ile Cys Gly Pro Gly Thr Asn Tyr Asp 
    50                  55                  60                  


Ile Gln Phe Glu Phe Phe Arg Gly Pro Cys Val Val Pro Lys Val Ser 
65                  70                  75                  80  


Gly Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro Asp Pro Asn Lys 
                85                  90                  95      


Phe Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr Thr Gln Arg Leu 
            100                 105                 110         


Val Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly Gln Pro Leu Gly 
        115                 120                 125             


Val Gly Val Ser Gly His Pro Leu Leu Asn Lys Tyr Asp Asp Val Glu 
    130                 135                 140                 


Asn Ser Gly Gly Tyr Gly Gly Asn Pro Gly Gln Asp Asn Arg Val Asn 
145                 150                 155                 160 


Val Gly Met Asp Tyr Lys Gln Thr Gln Leu Cys Met Val Gly Cys Ala 
                165                 170                 175     


Pro Pro Leu Gly Glu His Trp Gly Lys Gly Thr Gln Cys Ser Asn Thr 
            180                 185                 190         


Ser Val Gln Asn Gly Asp Cys Pro Pro Leu Glu Leu Ile Thr Ser Val 
        195                 200                 205             


Ile Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met Asn Phe 
    210                 215                 220                 


Ala Asp Leu Gln Thr Asn Lys Ser Asp Val Pro Leu Asp Ile Cys Gly 
225                 230                 235                 240 


Thr Val Cys Lys Tyr Pro Asp Tyr Leu Gln Met Ala Ala Asp Pro Tyr 
                245                 250                 255     


Gly Asp Arg Leu Phe Phe Tyr Leu Arg Lys Glu Gln Met Phe Ala Arg 
            260                 265                 270         


His Phe Phe Asn Arg Ala Gly Thr Val Gly Glu Pro Val Pro Asp Asp 
        275                 280                 285             


Leu Leu Val Lys Gly Gly Asn Asn Arg Ser Ser Val Ala Ser Ser Ile 
    290                 295                 300                 


Tyr Val His Thr Pro Ser Gly Ser Leu Val Ser Ser Glu Ala Gln Leu 
305                 310                 315                 320 


Phe Asn Lys Pro Tyr Trp Leu Gln Lys Ala Gln Gly His Asn Asn Gly 
                325                 330                 335     


Ile Cys Trp Gly Asn His Leu Phe Val Thr Val Val Asp Thr Thr Arg 
            340                 345                 350         


Ser Thr Asn Met Thr Leu Cys Ala Ser Val Ser Lys Ser Ala Thr Tyr 
        355                 360                 365             


Thr Asn Ser Asp Tyr Lys Glu Tyr Met Arg His Val Glu Glu Phe Asp 
    370                 375                 380                 


Leu Gln Phe Ile Phe Gln Leu Cys Ser Ile Thr Leu Ser Ala Glu Val 
385                 390                 395                 400 


Met Ala Tyr Ile His Thr Met Asn Pro Ser Val Leu Glu Asp Trp Asn 
                405                 410                 415     


Phe Gly Leu Ser Pro Pro Pro Asn Gly Thr Leu Glu Asp Thr Tyr Arg 
            420                 425                 430         


Tyr Val Gln Ser Gln Ala Ile Thr Cys Gln Lys Pro Thr Pro Glu Lys 
        435                 440                 445             


Glu Lys Gln Asp Pro Tyr Lys Asp Met Ser Phe Trp Glu Val Asn Leu 
    450                 455                 460                 


Lys Glu Lys Phe Ser Ser Glu Leu Asp Gln Phe Pro Leu Gly Arg Lys 
465                 470                 475                 480 


Phe Leu Leu Gln Ser Gly Tyr Arg Gly Arg Thr Ser Ala Arg Thr Gly 
                485                 490                 495     


Ile 
    


<210>  6
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  6

Ser Thr Met Glu Phe Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val 
1               5                   10                  15      


Pro Pro Pro Asn Pro Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val 
            20                  25                  30          


Lys Arg Thr Asn Ile Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala 
        35                  40                  45              


Val Gly His Pro Tyr Tyr Ser Ile Lys Lys Val Asn Lys Thr Val Val 
    50                  55                  60                  


Pro Lys Val Ser Gly Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro 
65                  70                  75                  80  


Asp Pro Asn Lys Phe Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr 
                85                  90                  95      


Thr Gln Arg Leu Val Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly 
            100                 105                 110         


Gln Pro Leu Gly Val Gly Val Ser Gly His Pro Leu Leu Asn Lys Tyr 
        115                 120                 125             


Asp Asp Val Glu Asn Ser Gly Gly Tyr Gly Gly Asn Pro Gly Gln Asp 
    130                 135                 140                 


Asn Arg Val Asn Val Gly Met Asp Tyr Lys Gln Thr Gln Leu Cys Met 
145                 150                 155                 160 


Val Gly Cys Ala Pro Pro Leu Gly Glu His Trp Gly Lys Gly Thr Gln 
                165                 170                 175     


Cys Ser Asn Thr Ser Val Gln Asn Gly Asp Cys Pro Pro Leu Glu Leu 
            180                 185                 190         


Ile Thr Ser Val Ile Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly 
        195                 200                 205             


Ala Met Asn Phe Ala Asp Leu Gln Thr Asn Lys Ser Asp Val Pro Leu 
    210                 215                 220                 


Asp Ile Cys Gly Thr Val Cys Lys Tyr Pro Asp Tyr Leu Gln Met Ala 
225                 230                 235                 240 


Ala Asp Pro Tyr Gly Asp Arg Leu Phe Phe Tyr Leu Arg Lys Glu Gln 
                245                 250                 255     


Met Phe Ala Arg His Phe Phe Asn Arg Ala Gly Thr Val Gly Glu Pro 
            260                 265                 270         


Val Pro Asp Asp Leu Leu Val Lys Gly Gly Asn Asn Arg Ser Ser Val 
        275                 280                 285             


Ala Ser Ser Ile Tyr Val His Thr Pro Ser Gly Ser Leu Val Ser Ser 
    290                 295                 300                 


Glu Ala Gln Leu Phe Asn Lys Pro Tyr Trp Leu Gln Lys Ala Gln Gly 
305                 310                 315                 320 


His Asn Asn Gly Ile Cys Trp Gly Asn His Leu Phe Val Thr Val Val 
                325                 330                 335     


Asp Thr Thr Arg Ser Thr Asn Met Thr Leu Cys Ala Ser Val Cys Gly 
            340                 345                 350         


Pro Arg Ala Leu Phe Gln Asp Ser Asp Pro Lys Arg Phe Gln Asn Gly 
        355                 360                 365             


Pro Cys Thr Tyr Thr Asn Ser Asp Tyr Lys Glu Tyr Met Arg His Val 
    370                 375                 380                 


Glu Glu Phe Asp Leu Gln Phe Ile Phe Gln Leu Cys Ser Ile Thr Leu 
385                 390                 395                 400 


Ser Ala Glu Val Met Ala Tyr Ile His Thr Met Asn Pro Ser Val Leu 
                405                 410                 415     


Glu Asp Trp Asn Phe Gly Leu Ser Pro Pro Pro Asn Gly Thr Leu Glu 
            420                 425                 430         


Asp Thr Tyr Arg Tyr Val Gln Ser Gln Ala Ile Thr Cys Gln Lys Pro 
        435                 440                 445             


Thr Pro Glu Lys Glu Lys Gln Asp Pro Tyr Lys Asp Met Ser Phe Trp 
    450                 455                 460                 


Glu Val Asn Leu Lys Glu Lys Phe Ser Ser Glu Leu Asp Gln Phe Pro 
465                 470                 475                 480 


Leu Gly Arg Lys Phe Leu Leu Gln Ser Gly Tyr Arg Gly Arg Thr Ser 
                485                 490                 495     


Ala Arg Thr Gly Ile 
            500     


<210>  7
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  7

Ser Thr Met Glu Phe Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val 
1               5                   10                  15      


Pro Pro Pro Asn Pro Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val 
            20                  25                  30          


Lys Arg Thr Asn Ile Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala 
        35                  40                  45              


Val Gly His Pro Tyr Tyr Ser Ile Lys Lys Val Asn Lys Thr Val Val 
    50                  55                  60                  


Pro Lys Val Ser Gly Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro 
65                  70                  75                  80  


Asp Pro Asn Lys Phe Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr 
                85                  90                  95      


Thr Gln Arg Leu Val Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly 
            100                 105                 110         


Gln Pro Leu Gly Val Gly Val Ser Gly His Pro Leu Leu Asn Lys Tyr 
        115                 120                 125             


Asp Asp Val Glu Asn Ser Gly Gly Tyr Gly Gly Asn Pro Gly Gln Asp 
    130                 135                 140                 


Asn Arg Val Asn Val Gly Met Asp Tyr Lys Gln Thr Gln Leu Cys Met 
145                 150                 155                 160 


Val Gly Cys Ala Pro Pro Leu Gly Glu His Trp Gly Lys Gly Thr Gln 
                165                 170                 175     


Cys Ser Asn Thr Ser Val Gln Asn Gly Asp Cys Pro Pro Leu Glu Leu 
            180                 185                 190         


Ile Thr Ser Val Ile Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly 
        195                 200                 205             


Ala Met Asn Phe Ala Asp Leu Gln Thr Asn Lys Ser Asp Val Pro Leu 
    210                 215                 220                 


Asp Ile Cys Gly Thr Val Cys Lys Tyr Pro Asp Tyr Leu Gln Met Ala 
225                 230                 235                 240 


Ala Asp Pro Tyr Gly Asp Arg Leu Phe Phe Tyr Leu Arg Lys Glu Gln 
                245                 250                 255     


Met Phe Ala Arg His Phe Phe Asn Arg Ala Gly Thr Val Gly Glu Pro 
            260                 265                 270         


Val Pro Asp Asp Leu Leu Val Lys Gly Gly Asn Asn Arg Ser Ser Val 
        275                 280                 285             


Ala Ser Ser Ile Tyr Val His Thr Pro Ser Gly Ser Leu Val Ser Ser 
    290                 295                 300                 


Glu Ala Gln Leu Phe Asn Lys Pro Tyr Trp Leu Gln Lys Ala Gln Gly 
305                 310                 315                 320 


His Asn Asn Gly Ile Cys Trp Gly Asn His Leu Phe Val Thr Val Val 
                325                 330                 335     


Asp Thr Thr Arg Ser Thr Asn Met Thr Leu Cys Ala Ser Val Cys Gly 
            340                 345                 350         


Pro Gln Asp Ile Trp Lys Val Pro Glu Ser Ser Arg Gly Pro Cys Thr 
        355                 360                 365             


Tyr Thr Asn Ser Asp Tyr Lys Glu Tyr Met Arg His Val Glu Glu Phe 
    370                 375                 380                 


Asp Leu Gln Phe Ile Phe Gln Leu Cys Ser Ile Thr Leu Ser Ala Glu 
385                 390                 395                 400 


Val Met Ala Tyr Ile His Thr Met Asn Pro Ser Val Leu Glu Asp Trp 
                405                 410                 415     


Asn Phe Gly Leu Ser Pro Pro Pro Asn Gly Thr Leu Glu Asp Thr Tyr 
            420                 425                 430         


Arg Tyr Val Gln Ser Gln Ala Ile Thr Cys Gln Lys Pro Thr Pro Glu 
        435                 440                 445             


Lys Glu Lys Gln Asp Pro Tyr Lys Asp Met Ser Phe Trp Glu Val Asn 
    450                 455                 460                 


Leu Lys Glu Lys Phe Ser Ser Glu Leu Asp Gln Phe Pro Leu Gly Arg 
465                 470                 475                 480 


Lys Phe Leu Leu Gln Ser Gly Tyr Arg Gly Arg Thr Ser Ala Arg Thr 
                485                 490                 495     


Gly Ile 
        


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  8

Gln Thr Phe Thr Glu Leu Glu Ile Arg Gly Glu Trp 
1               5                   10          


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  9

Asn Ser Leu Ser Tyr Ser Phe Tyr Asn His Ser Leu Phe Arg 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  10

Arg Ala Leu Phe Gln Asp Ser Asp Pro Lys Arg Phe Gln Asn 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  11

Glu Ile Glu Leu Met Glu Ser Thr Asn Thr Ala Leu Trp Pro 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  12

Phe Arg Glu Tyr Ser Arg Ser Thr Ile Glu Gly Leu Glu Tyr 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  13

Arg Glu Tyr Ser Arg Ser Thr Ile Glu Gly Leu Glu Tyr Asn 
1               5                   10                  


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  14

Gln Asp Ile Trp Lys Val Pro Glu Ser Ser Arg 
1               5                   10      


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  15

Gly Thr Asn Tyr Asp Ile Gln Phe Glu Phe Phe Arg 
1               5                   10          


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  16

Arg Lys Ile Lys Gly Asn His Ser Ala Tyr Leu His Phe Ala Asp Gly 
1               5                   10                  15      


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  17

Gly Val Thr Asp Arg Gly Asp Leu Glu Asn Trp Gly Asn 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  18

Gln Glu Glu Leu Asp Lys Arg Lys Phe Thr Val Ser Arg 
1               5                   10              


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  19

Arg Thr Asn Ser Tyr Leu Gly Gln Lys His Tyr Glu 
1               5                   10          


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  20

Tyr Thr Asp Phe Gln Met Asp Glu Arg Glu Tyr Ala Met Glu 
1               5                   10                  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  21

Arg Arg Val Lys Asp Gln Asn Arg Gly Lys Val Arg Val Ala Gln Lys 
1               5                   10                  15      


His Pro Glu Thr 
            20  


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Peptide

<400>  22

Asp Gly Thr Val Tyr Leu Arg Thr Glu Asp Glu Phe Thr Lys Leu Asp 
1               5                   10                  15      


Glu Ser 
        


