
                                SEQUENCE LISTING

<110> Kawaoka, Yoshihiro
      Takada, Kosuke
      Imai, Masaki
      Wisconsin Alumni Research Foundation (WARF)
      National University Corporation, University of Tokyo

<120> HUMANIZED CELL LINE
  

<130> 800.105WO1

<140> PCT/US2020/017342   
<141> 2020-02-07  

<150> US 62/803,266       
<151> 2019-02-08  

<160> 151

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 406
<212> PRT
<213> Homo sapiens

<400> 1
Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val
 1               5                  10                  15
Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly
            20                  25                  30
Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu
        35                  40                  45
Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser
    50                  55                  60
Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser
65                  70                  75                  80
Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp
                85                  90                  95
Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile
            100                 105                 110
Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly
        115                 120                 125
Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu
    130                 135                 140
Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe
145                 150                 155                 160
Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr
                165                 170                 175
Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser
            180                 185                 190
Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val
        195                 200                 205
Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly
    210                 215                 220
Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu
225                 230                 235                 240
Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val
                245                 250                 255
Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn
            260                 265                 270
Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His
        275                 280                 285
Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu
    290                 295                 300
Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro
305                 310                 315                 320
Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp
                325                 330                 335
Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val
            340                 345                 350
Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala
        355                 360                 365
Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln
    370                 375                 380
Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly
385                 390                 395                 400
Phe Arg Thr Ile His Cys
                405

<210> 2
<211> 529
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile
 1               5                  10                  15
Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp
            20                  25                  30
Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr
        35                  40                  45
Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala
    50                  55                  60
Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu
65                  70                  75                  80
Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu
                85                  90                  95
Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe
            100                 105                 110
Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp
        115                 120                 125
Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr
    130                 135                 140
Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu
145                 150                 155                 160
Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg
                165                 170                 175
His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly
            180                 185                 190
Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp
        195                 200                 205
Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala
    210                 215                 220
Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly
225                 230                 235                 240
Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg
                245                 250                 255
Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser
            260                 265                 270
Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu
        275                 280                 285
His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala
    290                 295                 300
Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val
305                 310                 315                 320
Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly
                325                 330                 335
Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro
            340                 345                 350
Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val
        355                 360                 365
Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys
    370                 375                 380
Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg
385                 390                 395                 400
Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln
                405                 410                 415
Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn
            420                 425                 430
Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met Cys
        435                 440                 445
Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr Glu
    450                 455                 460
Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu Gly
465                 470                 475                 480
Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu Val Gln Arg Leu Asn
                485                 490                 495
Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu Pro
            500                 505                 510
Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro His
        515                 520                 525
Ser


<210> 3
<211> 353
<212> PRT
<213> Homo sapiens

<400> 3
Ala Ala Met Gly Ser Asp Ser Gln Ser Val Ser Ser Ser Ser Thr Gln
 1               5                  10                  15
Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser Leu Arg Gly Leu Ala
            20                  25                  30
Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp Asn Lys Asp Ser Ser
        35                  40                  45
Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile Trp Lys Asn Tyr Leu
    50                  55                  60
Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly Pro Gly Pro Gly Ile
65                  70                  75                  80
Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu Arg Asp His Val Asn
                85                  90                  95
Val Ser Met Val Glu Val Thr Asp Phe Pro Phe Asn Thr Ser Glu Trp
            100                 105                 110
Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr Lys Ala Gly Pro Trp
        115                 120                 125
Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser Leu Lys Ser Ser Gln
    130                 135                 140
Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val Leu Arg Phe Asn Gly
145                 150                 155                 160
Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly Thr Lys Thr Thr Ile
                165                 170                 175
Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu Lys Arg Phe Leu Lys
            180                 185                 190
Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val Trp Asp Pro Ser Val
        195                 200                 205
Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn Pro Asp Tyr Asn Phe
    210                 215                 220
Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His Pro Asn Gln Pro Phe
225                 230                 235                 240
Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu Trp Asp Ile Leu Gln
                245                 250                 255
Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro Pro Ser Ser Gly Met
            260                 265                 270
Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp Gln Val Asp Ile Tyr
        275                 280                 285
Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val Cys Tyr Tyr Tyr Gln
    290                 295                 300
Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala Tyr His Pro Leu Leu
305                 310                 315                 320
Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln Gly Thr Asp Glu Asp
                325                 330                 335
Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly Phe Arg Thr Ile His
            340                 345                 350
Cys


<210> 4
<211> 529
<212> PRT
<213> Homo sapiens

<400> 4
Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile
 1               5                  10                  15
Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp
            20                  25                  30
Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr
        35                  40                  45
Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala
    50                  55                  60
Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu
65                  70                  75                  80
Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu
                85                  90                  95
Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe
            100                 105                 110
Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp
        115                 120                 125
Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr
    130                 135                 140
Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu
145                 150                 155                 160
Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg
                165                 170                 175
His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly
            180                 185                 190
Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp
        195                 200                 205
Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala
    210                 215                 220
Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly
225                 230                 235                 240
Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg
                245                 250                 255
Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser
            260                 265                 270
Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu
        275                 280                 285
His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala
    290                 295                 300
Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val
305                 310                 315                 320
Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly
                325                 330                 335
Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro
            340                 345                 350
Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val
        355                 360                 365
Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys
    370                 375                 380
Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg
385                 390                 395                 400
Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln
                405                 410                 415
Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn
            420                 425                 430
Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met Cys
        435                 440                 445
Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr Glu
    450                 455                 460
Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu Gly
465                 470                 475                 480
Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu Val Gln Arg Leu Asn
                485                 490                 495
Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu Pro
            500                 505                 510
Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro His
        515                 520                 525
Ser


<210> 5
<211> 6830
<212> DNA
<213> Canis familiaris

<400> 5
gtcaggtctc agaaaagtct agaataaggc ttacaggcac tttgttcagt tgtggaacac      60
atggaaactt catacaccgc ccccctcctt gcagaccgga gagctctctg ctctaatttg     120
ggcacaggcg cccaaccttg ggccccagag gaagcctgtt ctactcccag ggccaacgct     180
caattgcttg gtaacttggc acccacactg ttccaggctc tggtctcagt ttcactctct     240
gcaaaatgag aggctcagag ttccgctgac atggcctcgg ggccgttaaa acctttcttc     300
atgaagacag cctgcaccct tcctgcttct gctccaggtc catcctcaga accttccaga     360
aagtcctggc acgtcagata acagggccaa cccggcagtg atgccccacc ccccacccct     420
tcccttactc atagagcctg ctccagactc tcagagccca cacccacttg gtgaagtcat     480
ttgccagtaa ttcttcgcac tggacattga gaggtttcag accccagaag tctcaggcgc     540
tgggtctgaa agtgggcaga gcccaggtga catttgtgga gactctcagt ggtgcgtata     600
gccgccggga ccattttcag actcaacctt tctgacctgg aaatgccaat agaagtaatc     660
atcatcgcca ggggctgtgg tgagcaaatg cttggagctc tgtggccagg gcagtttcat     720
ttgaggacca gagatggaca atccctcagc ctactgagat gaagaaactg agtctcagag     780
aggttaagga actcccccga ggttgcacca ctgaggaaga ttgacctgac ttcccaagac     840
catacatctg gtaaaccgga acctgcacct gcgccatctc aagcctactc tggaggcccg     900
aggctaattg gcagagtttg agggctgaga tgacagacaa ccctcagtgc cttcatcggg     960
cgggctgctt acctgcacat ccctggtgac agcatgggaa agaccgcttc taattaagcg    1020
tcatcacaca tcaccctttt ccggaggaag agaggcaaag acagctcccc tctatcctgc    1080
actgtgaacc ttcctccgag gtcctcccct cacccccgag agtccttgcc ctgtcaccaa    1140
gattaattac ccctcaaccc ctttggatgg caaaggcagt cattttatta agtttgatta    1200
aagcttcaag agacattgcc ggatgtttca ggactgctga caaagcagcc tgcttgtttc    1260
ctgaaaagac caattatatg caagaagcgt cagccccact ccccgagggg tccacttagc    1320
ctccgaccac cacagggtga tgtccagcgc accggtgtgg ccatcacctg gcgggagtga    1380
ggtcggccgt agcaggtctg gaggcccccc tgcaagtccc tgcctcaccc tgtgactgag    1440
cctctcgtct ctgggaattt tgttccaaat tccccgtcta ccaggtgtga tttcctccag    1500
ccccaccagc cctgggaggc gcccatccag agagcagaga tggtgaccat gagaaagagg    1560
actctcaaag tgctcaccct cctcgtcctc ttcatcttcc tcacctcctt cttcctgaat    1620
tactcccaca ccatggtgac caccacctgg tttcccaagc agatggttgt cgagctctca    1680
gagaacttta agaagttcat gaaatacact cacaggcctt gcacctgtgc ccgctgcatc    1740
gggcagcaga gggtctcggc ctggttcgat gagaggttca accggtccat gcagccgctg    1800
ctgaccgccc agaacgccct cttggaggag gacacctaca gctggtggct gaggctccag    1860
cgggagaagc aacccaacaa cttgaacgat accatcaggg agctgttcca ggtggtgccc    1920
gggaacgtgg accccctgct ggagaagagg tcggtgggct gccggcgctg cgcagtcgtg    1980
ggcaactctg gcaacctccg agagtcctgg tacgggcctc agatcgacag ccacgacttc    2040
gtgctcagga tgaacaaggc ccccacggcg ggcttcgaga tggatgtcgg gagcaagacc    2100
acccaccacc tggtgtaccc cgagagcttc agggagctgg cggagaatgt cagcatggtc    2160
ctggtgccct tcaagaccac cgacctggag tgggtggtca gtgccaccac cacaggcacc    2220
atctctcaca cctatgttcc tgttcctgca aagatcaaag tgaaaaagga taagatcctc    2280
atctaccacc cggccttcat caagtacgtc ttcgacagct ggctgcaggg ccacgggcgg    2340
tacccgtcca ccggcatcct ctccgtcatc ttctcgctgc acatctgcga cgaggtggac    2400
ttgtacggct tcggggcaga cagtaagggg aactggcatc actactggga gaacaatcca    2460
tcggcggggg ctttccgcaa gaccggggtg cacgacggag actttgagtc caacgtgacg    2520
gccaccttgg cgtccatcaa taagatccgg atatttaagg ggagatgacg ctgccgagga    2580
gcaccggagc ccgcctcttt ggccagcccc agcctctgct ggagccgatc tgtgctgggg    2640
gctttgaggg ccagcctcgg gggcgtgttc aggtgcccct cgtgccccct cgcaccccga    2700
catttggcag catcgactca gcaaggcccc agagccccgc tgggtctgca gagcgagtgt    2760
cagaactggt cttggatggg gacacccccc ctccacctcc ctgcaccgcc actgctgtcc    2820
tggagcaggg ggcaggtggg gagacgcggg aggaggtccg gtctccaaac gctcaagtca    2880
tttcggcttt ggggggcaga gggggagata tcgaagactc tgtgttctaa agtgaaggac    2940
actggccctg ggcagagggg tcccgggctg actctctgac tctgatgctt gctgggtgag    3000
gacgacctcg ggacagagcc acatcgggcc acgtggacgc tgggggtgag aaggcacctt    3060
cctctgcacg atgcccggcc cctccctcac cgcctctgcg gtcttcccga agctcctccg    3120
tggcggccag gagaggcgcc ctgcgccgag ggtcctcaca gatgcttggc caagtgtttc    3180
agactccagc aggtgtcttc ttcgcaagct gaggctccct tgagtgatcg atctttgtgg    3240
ccataaatga tggctgagag cagatctgac tacttccacg tgcctttgtg tctgggggag    3300
agctgtgcgc attggctgaa ataaggcaaa agccttaatt cgggagtggg gagctccccc    3360
ctctccccgc ccccagcaat gccaccccct tgctctggag ctgggtaaca tctttactag    3420
tttcctgagg cggtgccgga gctggaatga agctaggatg atgctcaacg gcgtccagag    3480
gtgcgtcagc cgcggcacgt cattcttagg ttcacagact gatggatttg gggcccgtga    3540
ccttccaagg ccacacacag aacctccacc agccagcact ttgccccagg agcccaccct    3600
ccaggccaag tccctccggg ccacctgcac agtgtcctgg ggtttgtggg gccatcccag    3660
gaacatgacc ctcggagcgg gagaagacat acctcatcct ctcacttctg ggctgctctg    3720
attcctcctc atgattattt attgattttt ttttaattca gctgacattg cgtgcacttt    3780
gtggctccgt ggctggtcct gatgttttaa ttaagcttgc tctcgcttca cctggcagcc    3840
ggggcatggg gggcttaagt caaggtttgc aggagtcctc agacttggga gggggatgca    3900
tatctagggc ttgggggctc gtcggtgggc aaatgccagg gtttcaggtt ggtaggttct    3960
ccgagtgctc tgtacctcct tcccctcagc tctgcctccc ttctccatca ttgcgggttg    4020
ggatcattct caggctaaga atctgcaaaa cccagtgaga cggccttggg gccaggtggg    4080
gagtggagtc acacaggcag ggcagcgatg gttggctccg gttgctgaca ctgaatcaga    4140
aaatccacgt ttcctattga gagcatttcc taacaggcca ctgctacttc gaggaggtgt    4200
gacagtgtcc tggctgtcac gggggcccgt ctcctgtgct ccttgcagca gcactccggc    4260
aagttctgct ctcctggctt cagtctctgc ctctgcaaac ggagagggag gcatttgggg    4320
agctcagggg gccacaggtg gtttcagggg gttcacaagc gtccccagag agagcacacc    4380
acgcccgtgt tttaccccaa gcctgtgtgt atgagcatat attcctgggg agcggtgccg    4440
tagcgttcat tcaattgtca gaggttcaga acccagacaa tggtttacaa aaacacgaaa    4500
cgacagcaag caaacaaaaa cccgttcgag ctttaaaatc ctccaacact tagactctct    4560
tgacccctaa aggctcataa atcactacga ggtcagcaag ctgatcataa atcccaaaga    4620
ctatatagca ggcatctgtg ggttggctga tgaatccgct gagagaagtg ggtgcggagc    4680
ggcctccgag ctcctccccg agtcctggaa gagccgagtc cagtcagagc tgatgggtcc    4740
agagcgctca gcctgcgtcg gggctgtgct gagtcaggac aggtccccag agtaaggggg    4800
ggggtctctc tccctcccca ccccactgag ccgtccaggc tgttgagagg acttcccacc    4860
tgccttccca tgtaacactt gagaaaagcg aggcccggag aagggaagtg gcttgcaaag    4920
tgaacccgtg gtgctggaca acgcaagtca gaccctttga gcaaagatag agcacgattg    4980
ctacatgttg aacacacctc gaggtgggct ttcccagccg gcttccatcc agcctcccca    5040
aggactgtga ccgggcacag gtgggctcct caggctgcac gtggtggccc ccgcaagctc    5100
cggtgtctgc cttttccccc catccctcca gtgagggaga cacccttgct cttccctcag    5160
ccccagcaaa cttgtctttg tgttcgttgg cttagcaaag gggtctgacc cgaatgcacc    5220
aacgggcttc agccccctgg catctgtacc tggggtaagg gtggctgaga atccaaccag    5280
agtatttccc ccagagctcg tggctgtggg caggttaacg agaaccaccc gcccccccca    5340
ctcggaggag gctcctgaat gcccacccca gtgttgggct cccagcctag ggccctgctt    5400
gctcctcaag cacagagctc ccttggaggc cagtcctgga cccctgggca gggagcagag    5460
gcatccctgc ctctctcagt gctgagcccg aagccaggaa gaccagggcc gaggagggag    5520
agagagattt taacaccctc cccggccctg gggagccagg agctggagtc acctgccgca    5580
aatgcaaggc ctggttccac gtgcccccct ccgcccctgt cctcaccccc ttgttagggt    5640
gggtttgtag cgtctggctc ccagagccat caggcaaaaa agaaagttct taaagagatg    5700
cttttagggg cctgtgctta gtgggagaag ccagattcaa gaaaatggga cttaaaacgg    5760
ggaagccaga cgagaaggtg gggggggggt tgtccgggtg tgattcttac aagtgctgag    5820
gccagaagga tggaccctct ccaggtccag agtagagtgg agtcaacggg gaatatttag    5880
gactgtgatg tttgcagtaa tggtcctctt caaggcagcc tggacacaaa gcaaaatcgg    5940
aaacagaaaa gaactcacca tcccttgcgt gggtaggacc aaaacagctt tctccaggga    6000
ggcgcaagcc ctgagtggcc gccgtctggc caaagccggc ctcgtgccat cgggaaccgg    6060
ccaccgccca tgcccctccg gagagctcgg ggtcgtcatc gtgtccacca cgggcatctg    6120
gtcggaagca aacgttccca caggccactg gctggtcatc gtcccctgtg gtctgggctg    6180
accggtttga gaccaagtcc gctgccttgc tccggcctgt cctgaagaca ccagcgcccc    6240
ggcctgtggg gtgccccgtg atgcctccat gcagggaaga gcaggggacc agggaggaag    6300
agcagagaca ggtgaagcga cagtccccgc gtcccagcct cagcattcgc atcctcttgg    6360
cccctacttt tcctctccgc ccagcagaca tctgccctgc ccttgccctt gaccccattg    6420
ctgcgcttcc ctcaaggacg ggcctggcct tggtggccac ctgcggacag ccctgcgccc    6480
gacgcccgct tcaccccggg gcccgggtct ggaggggccg cccccaggac gaacgcggct    6540
gccccacggg gccggcccct caccggcttc gcgtccaagc caaagtttct cgagcacttt    6600
tttgttcttt gcaatcatgt tgggttcatt gttggtgttt taaaattttg cttccctctc    6660
cctctggcct cgctcctgtg tgtgttttgt agccgagcgc taacctggat gcttttttga    6720
atgacctttg caagagcctg ccttcctcgg cctctgctct gttttattta ttgttgaata    6780
tttccaatga tccaaatcaa agtgaattaa aacaaagcta ttttatcgtt               6830



<210> 6
<211> 342
<212> PRT
<213> Canis familiaris

<400> 6
Met Val Thr Met Arg Lys Arg Thr Leu Lys Val Leu Thr Leu Leu Val
 1               5                  10                  15
Leu Phe Ile Phe Leu Thr Ser Phe Phe Leu Asn Tyr Ser His Thr Met
            20                  25                  30
Val Thr Thr Thr Trp Phe Pro Lys Gln Met Val Val Glu Leu Ser Glu
        35                  40                  45
Asn Phe Lys Lys Phe Met Lys Tyr Thr His Arg Pro Cys Thr Cys Ala
    50                  55                  60
Arg Cys Ile Gly Gln Gln Arg Val Ser Ala Trp Phe Asp Glu Arg Phe
65                  70                  75                  80
Asn Arg Ser Met Gln Pro Leu Leu Thr Ala Gln Asn Ala Leu Leu Glu
                85                  90                  95
Glu Asp Thr Tyr Ser Trp Trp Leu Arg Leu Gln Arg Glu Lys Gln Pro
            100                 105                 110
Asn Asn Leu Asn Asp Thr Ile Arg Glu Leu Phe Gln Val Val Pro Gly
        115                 120                 125
Asn Val Asp Pro Leu Leu Glu Lys Arg Ser Val Gly Cys Arg Arg Cys
    130                 135                 140
Ala Val Val Gly Asn Ser Gly Asn Leu Arg Glu Ser Trp Tyr Gly Pro
145                 150                 155                 160
Gln Ile Asp Ser His Asp Phe Val Leu Arg Met Asn Lys Ala Pro Thr
                165                 170                 175
Ala Gly Phe Glu Met Asp Val Gly Ser Lys Thr Thr His His Leu Val
            180                 185                 190
Tyr Pro Glu Ser Phe Arg Glu Leu Ala Glu Asn Val Ser Met Val Leu
        195                 200                 205
Val Pro Phe Lys Thr Thr Asp Leu Glu Trp Val Val Ser Ala Thr Thr
    210                 215                 220
Thr Gly Thr Ile Ser His Thr Tyr Val Pro Val Pro Ala Lys Ile Lys
225                 230                 235                 240
Val Lys Lys Asp Lys Ile Leu Ile Tyr His Pro Ala Phe Ile Lys Tyr
                245                 250                 255
Val Phe Asp Ser Trp Leu Gln Gly His Gly Arg Tyr Pro Ser Thr Gly
            260                 265                 270
Ile Leu Ser Val Ile Phe Ser Leu His Ile Cys Asp Glu Val Asp Leu
        275                 280                 285
Tyr Gly Phe Gly Ala Asp Ser Lys Gly Asn Trp His His Tyr Trp Glu
    290                 295                 300
Asn Asn Pro Ser Ala Gly Ala Phe Arg Lys Thr Gly Val His Asp Gly
305                 310                 315                 320
Asp Phe Glu Ser Asn Val Thr Ala Thr Leu Ala Ser Ile Asn Lys Ile
                325                 330                 335
Arg Ile Phe Lys Gly Arg
            340

<210> 7
<211> 4577
<212> DNA
<213> Canis familiaris

<400> 7
cggctcgctc cgggagggca gagccggcaa gggcgggact ggcctgctgc gggcggacgg      60
gggagccgcg gagctaacgg gtccggacgt cgccagcggc ggagctttct gcacgggcgg     120
aggcggcggc aggagcggca agcatggccc gcgcggcgcc cggcgctgac tgagggtcat     180
gctgcggcag cctggcgcct gacgagtgag ggggaacctg ccaggggatt actgctagca     240
cgagctaaca gcaggacagc aggcctcagg ggagtgggga tgggcatagc agcctgcctg     300
caacgctggg ccagtggcac caaggaggcc caggccctgg cagggagctc ggcacacgct     360
cagctgaccc agacagcatt caaagcaggt ccctgctgag cagcagctgt tcccaggccc     420
tggaggaccg caaacgcctc agcaaccaca tttggggctg tgaccatcag gagaagggac     480
caacacctcg aatgggaagc agaagggcag aacctgctgc caggaggatc ttggtctctg     540
cagcaaagtc ttccgacacc cgtggagctt cttgggtttc tcctctcagg actggggcct     600
tgtttcctcc tctggtggag ggggtaggcc aggagggcca gctgaggtgg ggacgactct     660
cggatggaat ccaggccact tgaagcccat gggctctctg ctgtgattgg ggttcgaggg     720
cttccccact gcaggggacg aggggccgcc tccgtgtctg ctcatgaacc acaaggaccc     780
cgaatgctcc agactggacc atttcgagcc accaaagagt ggggccccca gagctggcag     840
ccagcagctc caagggacta gagagctggg atggactgac ctccccctca ccagggcatt     900
aggagagtca gagcctctgt ggcccagcta gtgacagaga gacccgatga ggccataagc     960
tggcacccga gtgactcagg gacaggagag ccactcctgc ctactgtgct ttctctttac    1020
attgagggag ggtgtggtaa gggacccctg cctctgttcc ctcctcagca cgtgccccta    1080
tgccctttgc acgtggtgcc aggagacgca ggctacactg tggctggccc atcagtgggc    1140
tgggaaggga gtggccacgg tgacacccac ccgcccacca ggctggtggt ctagcccccc    1200
ggggcgccaa accatgaagt gctccctgcg ggtgtggttc ctctctgtgg ccttcctgct    1260
ggtgttcatc atgtcactgc tctttaccta ctcccaccac agcatggcca ccttgcccta    1320
cctggactca ggggccctgg gcggtaccca ccgggtgaag ctggtgcctg gctatgctgg    1380
tctgcagcgc ctcagcaagg aggggctcac cggtaagagc tgtgcctgcc gccgctgcat    1440
gggtgacact ggcgcctctg actggtttga cagccacttc aacagcaaca tttcccctgt    1500
gtggacccga gagaatatgg atctgcctcc agatgtccag aggtggtgga tgatgctgca    1560
gccccagttc aagtcacaca acaccaacga ggtactggag aagctgttcc agatagtacc    1620
aggcgagaac ccctaccgtt tccgggaccc ccaccagtgc cggcgctgtg cggtagtggg    1680
gaactcaggc aacctgcggg gctctggcta cggcccagat gtggatgggc ataacttcat    1740
catgaggatg aatcaggcgc caaccgtggg ctttgagcag gatgttggca gccgaactac    1800
ccaccatttc atgtaccccg agagtgccaa gaaccttcct gccaacgtca gctttgtgtt    1860
ggtgcccttc aaagctctgg acctactatg gattgccagc gctttgtcca cagggcaaat    1920
cagattcacc tatgcgccag tgaagtcctt ccttcgagtg gacaaagaaa aggttcagat    1980
ctacaacccg gcattcttca agtacatcca cgaccggtgg acagagcatc acgggcggta    2040
cccttccaca gggatgctgg tgctcttctt tgccctgcat gtttgtgatg aggtgaacgt    2100
gtacgggttc ggggccgaca gccggggcaa ctggcaccac tactgggaga ataaccggta    2160
tgcgggcgag ttccggaaga cgggagtgca cgacgccgac ttcgaggccc acatcatcga    2220
catgctggcc aaggccagca agatcgaggt ctaccgaggc aactgagccc ggcctcgccg    2280
cgacccttcc ggcccagccg cgaggctgcg acgctcgctc cgcagccggg actcccggcc    2340
agcccgaggg cggcggcctt ggcgagggcg cggcgcccgg ttgggcgtct ccagccctgg    2400
gagcgacgcc aagtcgcggt ctggaccaat catgctgcaa gtccagcgag cgccggctgt    2460
cccccgccaa tcaggagact ttgggggctg gcccaggcct ggcacccaat cagcgctgca    2520
gtgggagcgg aggctctttc tcccagccaa tcatgcgact caaggagaac ttccggcgct    2580
gggcccggtc tcctccaatc aatggccttc ggaggcgggc cggccgccgc tgaatcccca    2640
ctcccctatg ctttgggtag gattttattt tatgcttttt aaggagtagt ggttggttcc    2700
ggcctcagtg gagtactttc ctcaggctct gcgggaggag tgttggtggc ctgtcggcgg    2760
tactcggcca ggggcaccga ggaggaagcg ggggggaagg tgcggggcag cagcggctgg    2820
gcctcccttg gccgggggcc cctcgcgacc tcggggcggg cgggggggcg ggggcgttgg    2880
cctcccgctt ctggaggtcc ggggggaatc aggtggtttc cggggagcgc gctttcatcc    2940
ccgggaagag ctagatccct ctcaaacctt ttcaggcctc agagcactct agaccgcgta    3000
tttcctttat ctgtcgggcc cagatgggtg agtgtaaacc caccaaagaa aggcagtgga    3060
gcgtgggtcc cctcgtcctc ccttgtcccc atccccacct ttggccaccc tatgggatgg    3120
ccttcctgac cagggcattg agcatcccac ctggaaacta gaactgtatt cacccgttgc    3180
tagggctcgg agttcgccga tggcctaact cgagcgcagg ggtaaggaac agggcagggg    3240
acccggaagc cccgtcactt cagatgtaag gtgcttctca ctctcgtgta ctctcgcggc    3300
cccttactgt tcgcccacaa cttttttagt gtcccttctt aagccctggg cctcctcacc    3360
agcctgctcg tcctgggatt gggggtgggg ggtggggcac tgctggcttc tccaaccccc    3420
tacccctcct cgctcgtctt tagccggctc tagggagagg aaggcaggct ggagatgggg    3480
agcccagctg cctggtgcat gcaccgtttt cctccgccca tcaccccaaa gaggagtagg    3540
aaacctcttg cttgggggtg gaatttgctt tggtctccta atttagttaa cttgaggtta    3600
ccagggatgg ctgaccaaca aagattcttt taaaattcca ggctggccat gcaaattgct    3660
gggatcctag ctggggagga gtcgactgac ttgcccgcct tgcatgtctc ctctcctgcc    3720
cctgcgtccc ctccctctgc cacgctcact tcctgcctca tctctccaac ccattttcca    3780
ttttcagctc tagaagggca gggacgctta caaacaggag ttacatctgg aagttacttc    3840
caagactgaa cccagcttaa gtccctagag gaagctgctg atgatattct cacccttcaa    3900
ggttggggaa gtttcggagg gggaaagtgc ttctgtgaag cttccaaacc actaatagga    3960
tcccccttcc caacaatgag gaacacaaac accacccttt atcttagttg ataccaccaa    4020
gcagcctcct ggccattggg gtaattcctg cagctggctg gggtaaccag caggggagta    4080
tattagagga ggattggggc agggcagtgg gcacccctaa agttaatata ttgagaactt    4140
agcttaagcc taagtcttag ttccttccca attccaaaag taggaggagc aacgagtggg    4200
ggtggatttg ggggggccta tcctggaatg cctctctcag ggcttccccc accattttag    4260
agagtcaagg caccagccat tcatgccagt ctcctctcag tgcttcctga agaggctgtt    4320
tggagtgttc ggaaaatgaa aaaaacaatg caattatgcc aaacagtatt gagcagaata    4380
atttatttct tttttgttcc tttttcttct ttttgttttg tttaaaacat taataaatcc    4440
cctttctgga agaggtaggt cccagcatcc agcccagatc tccttttctg caatagttat    4500
ttaaacaaat gtttgtttgt ttttttattt tcttcccttt ctctctcttt ctgaattaaa    4560
aaaaaagaaa actccta                                                   4577

<210> 8
<211> 350
<212> PRT
<213> Canis familiaris

<400> 8
Met Lys Cys Ser Leu Arg Val Trp Phe Leu Ser Val Ala Phe Leu Leu
 1               5                  10                  15
Val Phe Ile Met Ser Leu Leu Phe Thr Tyr Ser His His Ser Met Ala
            20                  25                  30
Thr Leu Pro Tyr Leu Asp Ser Gly Ala Leu Gly Gly Thr His Arg Val
        35                  40                  45
Lys Leu Val Pro Gly Tyr Ala Gly Leu Gln Arg Leu Ser Lys Glu Gly
    50                  55                  60
Leu Thr Gly Lys Ser Cys Ala Cys Arg Arg Cys Met Gly Asp Thr Gly
65                  70                  75                  80
Ala Ser Asp Trp Phe Asp Ser His Phe Asn Ser Asn Ile Ser Pro Val
                85                  90                  95
Trp Thr Arg Glu Asn Met Asp Leu Pro Pro Asp Val Gln Arg Trp Trp
            100                 105                 110
Met Met Leu Gln Pro Gln Phe Lys Ser His Asn Thr Asn Glu Val Leu
        115                 120                 125
Glu Lys Leu Phe Gln Ile Val Pro Gly Glu Asn Pro Tyr Arg Phe Arg
    130                 135                 140
Asp Pro His Gln Cys Arg Arg Cys Ala Val Val Gly Asn Ser Gly Asn
145                 150                 155                 160
Leu Arg Gly Ser Gly Tyr Gly Pro Asp Val Asp Gly His Asn Phe Ile
                165                 170                 175
Met Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Gln Asp Val Gly
            180                 185                 190
Ser Arg Thr Thr His His Phe Met Tyr Pro Glu Ser Ala Lys Asn Leu
        195                 200                 205
Pro Ala Asn Val Ser Phe Val Leu Val Pro Phe Lys Ala Leu Asp Leu
    210                 215                 220
Leu Trp Ile Ala Ser Ala Leu Ser Thr Gly Gln Ile Arg Phe Thr Tyr
225                 230                 235                 240
Ala Pro Val Lys Ser Phe Leu Arg Val Asp Lys Glu Lys Val Gln Ile
                245                 250                 255
Tyr Asn Pro Ala Phe Phe Lys Tyr Ile His Asp Arg Trp Thr Glu His
            260                 265                 270
His Gly Arg Tyr Pro Ser Thr Gly Met Leu Val Leu Phe Phe Ala Leu
        275                 280                 285
His Val Cys Asp Glu Val Asn Val Tyr Gly Phe Gly Ala Asp Ser Arg
    290                 295                 300
Gly Asn Trp His His Tyr Trp Glu Asn Asn Arg Tyr Ala Gly Glu Phe
305                 310                 315                 320
Arg Lys Thr Gly Val His Asp Ala Asp Phe Glu Ala His Ile Ile Asp
                325                 330                 335
Met Leu Ala Lys Ala Ser Lys Ile Glu Val Tyr Arg Gly Asn
            340                 345                 350

<210> 9
<211> 1782
<212> DNA
<213> Canis familiaris

<400> 9
ttggtggtcg cgctccgccc gccgctgcgt ccccaccatg gcggcgcccg tgcagcccac      60
cgcgtcgtgg gcgcccgccg ggctcccccg cggctgtggc ggccgcccgc gcctcggcct     120
ccgcctcccc gcccgcgccg gcccgggcgc cgcctccccg ctgcctccgt ctccgctgcg     180
gtcatgtagg aaatcgtaaa tcatgtgaag atgggactct tggtatttgt acgcaatctg     240
ctgctagccc tctgcctttt tctggtactg ggatttttgt attattctgc gtggaagctg     300
catttactcc agtgggagga ctccaattca gtggttcttt cctttgactc cgctggacaa     360
acactaggct cagagtatga tcggttgggt ttcctcctga agctggactc taaactgcct     420
gctgagttag ccaccaagta tgcaaacttt tcagagggag cttgcaagcc tggctatgct     480
tcggccttga tgactgccat ctttccccgg ttctccaagc cagcacccat gttcctggat     540
gactctttcc gcaagtgggc taggattcgg gagtttgtgc cgccttttgg gatcaaaggt     600
caagacaatc tgatcaaagc catcttgtca gtcaccaaag agtaccgcct gacccctgcc     660
ttggacagcc tcagctgccg ccgctgcatc atcgtgggca acggaggtgt cctagccaac     720
aagtctctgg ggtcacgaat tgatgactat gacattgtgg tcagactgaa ctccgcacca     780
gtgaaaggct ttgagaagga cgtgggcagc aaaactacac tgcgcatcac ctaccctgag     840
ggcgccatgc agcggcctga gcaatatgaa cgcgattctc tatttgtcct cgctggcttc     900
aagtggcagg acttcaagtg gttgaagtac atcgtctaca aggagagagt gctctgggcc     960
cgcagggata cctgccaatc tgtctgggcc catccccctc tcccctccac cagctgtcac    1020
cagccacccc aggggagggg tcctgcagag ttcaggccat tcttcttcca atacccgagc    1080
ctcctactgg aggagaatga tgacagacag cctctggcga caagtgcatc agatggcttc    1140
tggaaatccg tggccacacg agtgcccaag gagccccctg agattcgcat cctcaacccg    1200
tacttcatcc aggaggccgc cttcaccctc atcggactgc ccttcaacaa cggcctcatg    1260
ggccgcggga acatcccgac ccttggcagt gtggcagtga ccatggcgct acacggctgt    1320
gatgaggtgg cagtcgcagg ctttggctac gacatgagca cacccaacgc gcccctgcac    1380
tactatgaga ccgtgcgcat ggcagccatc aaagaggtca ccagcgactc agctcaaggc    1440
tgccaaatcc agtggacaca tggaagcctc atctttcctg acctcccaga aatgcttttt    1500
ctgttgacca ctccttcctc tttgaaactt ttcctgctca gactgtcctg gacacacaat    1560
atccagcgag agaaagagtt tctgcgcaag ctggtgaagg cgcgcgtcat caccgaccta    1620
accagcggca tctgaggtgg gcccagcaca tggccacgga ggtcctggca ccgccaagag    1680
gaagccgcag ccactgccac ctgtccactt cattggcctc ggtctggctc tgcctgaaag    1740
gcgcaggagt cttcagaccc agagaaggac agtgccaagg gg                       1782

<210> 10
<211> 474
<212> PRT
<213> Canis familiaris

<400> 10
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30
Leu Gln Trp Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser Ala
        35                  40                  45
Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu Lys
    50                  55                  60
Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn Phe
65                  70                  75                  80
Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr Ala
                85                  90                  95
Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp Ser
            100                 105                 110
Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly Ile
        115                 120                 125
Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys Glu
    130                 135                 140
Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Ser Cys Arg Arg Cys Ile
145                 150                 155                 160
Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser Arg
                165                 170                 175
Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val Lys
            180                 185                 190
Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr Tyr
        195                 200                 205
Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser Leu
    210                 215                 220
Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys Tyr
225                 230                 235                 240
Ile Val Tyr Lys Glu Arg Val Leu Trp Ala Arg Arg Asp Thr Cys Gln
                245                 250                 255
Ser Val Trp Ala His Pro Pro Leu Pro Ser Thr Ser Cys His Gln Pro
            260                 265                 270
Pro Gln Gly Arg Gly Pro Ala Glu Phe Arg Pro Phe Phe Phe Gln Tyr
        275                 280                 285
Pro Ser Leu Leu Leu Glu Glu Asn Asp Asp Arg Gln Pro Leu Ala Thr
    290                 295                 300
Ser Ala Ser Asp Gly Phe Trp Lys Ser Val Ala Thr Arg Val Pro Lys
305                 310                 315                 320
Glu Pro Pro Glu Ile Arg Ile Leu Asn Pro Tyr Phe Ile Gln Glu Ala
                325                 330                 335
Ala Phe Thr Leu Ile Gly Leu Pro Phe Asn Asn Gly Leu Met Gly Arg
            340                 345                 350
Gly Asn Ile Pro Thr Leu Gly Ser Val Ala Val Thr Met Ala Leu His
        355                 360                 365
Gly Cys Asp Glu Val Ala Val Ala Gly Phe Gly Tyr Asp Met Ser Thr
    370                 375                 380
Pro Asn Ala Pro Leu His Tyr Tyr Glu Thr Val Arg Met Ala Ala Ile
385                 390                 395                 400
Lys Glu Val Thr Ser Asp Ser Ala Gln Gly Cys Gln Ile Gln Trp Thr
                405                 410                 415
His Gly Ser Leu Ile Phe Pro Asp Leu Pro Glu Met Leu Phe Leu Leu
            420                 425                 430
Thr Thr Pro Ser Ser Leu Lys Leu Phe Leu Leu Arg Leu Ser Trp Thr
        435                 440                 445
His Asn Ile Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala
    450                 455                 460
Arg Val Ile Thr Asp Leu Thr Ser Gly Ile
465                 470

<210> 11
<211> 1819
<212> DNA
<213> Canis familiaris

<400> 11
ccctacaggc ccgagctgcc ggggtcgggc ctccccgggt tcccgctccc gggtcctcct      60
ggacacaccg gcctggcctg gctcccgggg aactctcgtc tgctagcggg gagcctccct     120
ccgcctcgcc cacgggcacc cctcccaccc agtatccttg gcctcttgca ggtggcccga     180
ggcagccggg atgacagctc tccccaggaa ccctgctacc ctctgagaaa catgatcagc     240
aagtcccgct ggaagctcct ggccatgttg gctctggtcc tggtcgtcat ggtgtggtat     300
tccatctccc gagaagacag gtacattgag cttttttatt ttcccatccc agagaagaag     360
gaaccgtgct tccagggtga ggcagagaga aaggcctcta agctctttgg caactactcc     420
cgagatcagc ccatcttcct gcagatgaag gattatttct gggtcaagac accgtctgcc     480
tacgagctgc cctatgggac caaggggagc gaagacctgc tcctccgggt tctagccatc     540
accagctact ccattccaga gagcatccag agtctcaagt gtcgccgctg cgtggtggtg     600
ggcaatgggc atcggctgcg caacagctcg ctgggagatg ccatcaacaa gtacgacgtg     660
gtcatcagac tgaacaacgc ccccgtggct ggctacgagg gtgacgtggg ctcgaagacc     720
accatgcgtc tcttctaccc ggagtcagcc cacttcaacc ccaaagtgga gaacaaccca     780
gacacacttc tcgtcctggt ggccttcaag gcaatggact tccactggat tgagaccatc     840
ctgagtgata agaagagggt acgaaagggc ttctggaagc agcctcccct catctgggac     900
gtcaacccca ggcaggttcg gattctcaac cctttcttta tggagattgc agctgacaaa     960
ctgctgaacc tgccaatgaa acagccacgc aagatttccc agaagcccac cacgggcctg    1020
ctggccatca cgctggctct ccacctctgc gacctggtgc acatcgccgg cttcggctac    1080
ccggacgccc acaacaggaa gcagaccatt cactactatg aacagatcac gctcaagtcc    1140
atggcggggt caggccacaa cgtctcccag gaggccctgg ccatcaagcg gatgctggag    1200
atcggagcag tcaagaacct cacgttcttc tgacggggac aggagctcta gccgtcagtc    1260
tgcccgccct gccgcctgag cgaccaacca cggctgtggg ggcgccggcg tgacctgctt    1320
ggattccccc tccccgtgtg gagagggggc ctggtacagg cggggcctga gatggggccg    1380
cgcccctggc tgctcttggg gcggccggat ccagtcaggg tggaggcccc gggtggcggg    1440
aggccttccg aggcgcgggg tgtgtggctg aggcacccct tctcaccagc cccgggagct    1500
tatttaatgg gctatttaat taaaagggta ggaatgtgcc tcgggctggt cccatggcat    1560
ccggaaacgg gggcatagca cagtggtctg cccactgtgg ataaaaacac acaagtgctt    1620
ggcccactag agcctagagc cagagcaggc ctcccaggag ggcaggggcg tctggagcgg    1680
gtgggtgccc tccagagagg ggctgctacc tcccagcggg catgggaaga gcattgggat    1740
gaggtcccac ggagaatggg acctcatgta gaaaagaggt ttgaaaccta acattaaact    1800
attttttcct aaaacggaa                                                 1819

<210> 12
<211> 333
<212> PRT
<213> Canis familiaris

<400> 12
Met Ile Ser Lys Ser Arg Trp Lys Leu Leu Ala Met Leu Ala Leu Val
 1               5                  10                  15
Leu Val Val Met Val Trp Tyr Ser Ile Ser Arg Glu Asp Arg Tyr Ile
            20                  25                  30
Glu Leu Phe Tyr Phe Pro Ile Pro Glu Lys Lys Glu Pro Cys Phe Gln
        35                  40                  45
Gly Glu Ala Glu Arg Lys Ala Ser Lys Leu Phe Gly Asn Tyr Ser Arg
    50                  55                  60
Asp Gln Pro Ile Phe Leu Gln Met Lys Asp Tyr Phe Trp Val Lys Thr
65                  70                  75                  80
Pro Ser Ala Tyr Glu Leu Pro Tyr Gly Thr Lys Gly Ser Glu Asp Leu
                85                  90                  95
Leu Leu Arg Val Leu Ala Ile Thr Ser Tyr Ser Ile Pro Glu Ser Ile
            100                 105                 110
Gln Ser Leu Lys Cys Arg Arg Cys Val Val Val Gly Asn Gly His Arg
        115                 120                 125
Leu Arg Asn Ser Ser Leu Gly Asp Ala Ile Asn Lys Tyr Asp Val Val
    130                 135                 140
Ile Arg Leu Asn Asn Ala Pro Val Ala Gly Tyr Glu Gly Asp Val Gly
145                 150                 155                 160
Ser Lys Thr Thr Met Arg Leu Phe Tyr Pro Glu Ser Ala His Phe Asn
                165                 170                 175
Pro Lys Val Glu Asn Asn Pro Asp Thr Leu Leu Val Leu Val Ala Phe
            180                 185                 190
Lys Ala Met Asp Phe His Trp Ile Glu Thr Ile Leu Ser Asp Lys Lys
        195                 200                 205
Arg Val Arg Lys Gly Phe Trp Lys Gln Pro Pro Leu Ile Trp Asp Val
    210                 215                 220
Asn Pro Arg Gln Val Arg Ile Leu Asn Pro Phe Phe Met Glu Ile Ala
225                 230                 235                 240
Ala Asp Lys Leu Leu Asn Leu Pro Met Lys Gln Pro Arg Lys Ile Ser
                245                 250                 255
Gln Lys Pro Thr Thr Gly Leu Leu Ala Ile Thr Leu Ala Leu His Leu
            260                 265                 270
Cys Asp Leu Val His Ile Ala Gly Phe Gly Tyr Pro Asp Ala His Asn
        275                 280                 285
Arg Lys Gln Thr Ile His Tyr Tyr Glu Gln Ile Thr Leu Lys Ser Met
    290                 295                 300
Ala Gly Ser Gly His Asn Val Ser Gln Glu Ala Leu Ala Ile Lys Arg
305                 310                 315                 320
Met Leu Glu Ile Gly Ala Val Lys Asn Leu Thr Phe Phe
                325                 330

<210> 13
<211> 1385
<212> DNA
<213> Canis familiaris

<400> 13
cgctctggaa ccacttacag ccacctggtg catcctcctt tggggtgcgt ttggagggcc      60
tggttcctgc tcagccacat cttctgccac tttcaccagc aatgcccagt gagtataact     120
atgtaaaact gagaagcgat cgctcaagac cctctctgca atggtacacc cgagctcaaa     180
acaagatgag aagacccaac ttgttgttaa aagacatcct taagtgtaca ttgcttgtgt     240
ttggagtgtg gatcctttat attctcaagt taaattatac tactgaagaa tgtgacatga     300
aaaaaatgca ttatgtggac ccagaccgtg taaagagagc tcagaaatat gctcagcaag     360
tcttgcaaaa ggagtgccga cccaagtttg cgaagaagtc gatggcgcag ttgttcgagc     420
acaggtacag cacggacttg ccacctttcg tgaaggagac ccccaaaatg aatgaagccg     480
agtacaagta tgatcctcct tttggattcc gaaagttctc cagtgaagtc cagaccctgt     540
tggaaatact gcccgagcat gacatgcccg aacacttgag agcaaagagc tgtaggcgtt     600
gtgtggtcat cggaagcggt ggcatactcc acggactagc actgggccag gccctcaacc     660
agttcgatgt ggtgataagg ttaaacagtg caccagttga gggatattct gagcatgttg     720
gtaataaaac tactataagg atgacttatc cagagggcgc gccactgtct gaccttgaat     780
attattccaa tgacttgttt gttgctgttt tattcaagag tgttgacttc aactggcttc     840
aagcaatggt aaaaaatgaa accctgccat tttgggtgcg gctcttcttt tggaagcagg     900
tggcggaaaa aatcccacta cagccaaaac atttcaggat tttgaatcca gttattatca     960
aagagactgc ctttgacatc cttcaatact cagagcccca gtcaaggttc tggggccgag    1020
ataagaacgt gcccaccatt ggtgtcattg ccgttgtctt agccacacat ctgtgtgatg    1080
aagtcagctt ggcaggcttt ggatatgacc tcaatcaacc caaaacacct ttgcactact    1140
ttgacaatct ctgcatggct gccatgaact ttcaaaccat gcataatgtg acaacggaga    1200
ccaggttcct cctcaagctg gtcaaagagg gcgtggtgaa ggatctcagc ggaggcatcc    1260
attgtgaatt ttgaacacag ggaaacctca tgtgacaatg caactctgac tctgaaggct    1320
gtttttcgta gccttctcga tgcagcgcat cctgcaaaat acttagaggt gcagctgggg    1380
ttttt                                                                1385

<210> 14
<211> 390
<212> PRT
<213> Canis familiaris

<400> 14
Met Pro Ser Glu Tyr Asn Tyr Val Lys Leu Arg Ser Asp Arg Ser Arg
 1               5                  10                  15
Pro Ser Leu Gln Trp Tyr Thr Arg Ala Gln Asn Lys Met Arg Arg Pro
            20                  25                  30
Asn Leu Leu Leu Lys Asp Ile Leu Lys Cys Thr Leu Leu Val Phe Gly
        35                  40                  45
Val Trp Ile Leu Tyr Ile Leu Lys Leu Asn Tyr Thr Thr Glu Glu Cys
    50                  55                  60
Asp Met Lys Lys Met His Tyr Val Asp Pro Asp Arg Val Lys Arg Ala
65                  70                  75                  80
Gln Lys Tyr Ala Gln Gln Val Leu Gln Lys Glu Cys Arg Pro Lys Phe
                85                  90                  95
Ala Lys Lys Ser Met Ala Gln Leu Phe Glu His Arg Tyr Ser Thr Asp
            100                 105                 110
Leu Pro Pro Phe Val Lys Glu Thr Pro Lys Met Asn Glu Ala Glu Tyr
        115                 120                 125
Lys Tyr Asp Pro Pro Phe Gly Phe Arg Lys Phe Ser Ser Glu Val Gln
    130                 135                 140
Thr Leu Leu Glu Ile Leu Pro Glu His Asp Met Pro Glu His Leu Arg
145                 150                 155                 160
Ala Lys Ser Cys Arg Arg Cys Val Val Ile Gly Ser Gly Gly Ile Leu
                165                 170                 175
His Gly Leu Ala Leu Gly Gln Ala Leu Asn Gln Phe Asp Val Val Ile
            180                 185                 190
Arg Leu Asn Ser Ala Pro Val Glu Gly Tyr Ser Glu His Val Gly Asn
        195                 200                 205
Lys Thr Thr Ile Arg Met Thr Tyr Pro Glu Gly Ala Pro Leu Ser Asp
    210                 215                 220
Leu Glu Tyr Tyr Ser Asn Asp Leu Phe Val Ala Val Leu Phe Lys Ser
225                 230                 235                 240
Val Asp Phe Asn Trp Leu Gln Ala Met Val Lys Asn Glu Thr Leu Pro
                245                 250                 255
Phe Trp Val Arg Leu Phe Phe Trp Lys Gln Val Ala Glu Lys Ile Pro
            260                 265                 270
Leu Gln Pro Lys His Phe Arg Ile Leu Asn Pro Val Ile Ile Lys Glu
        275                 280                 285
Thr Ala Phe Asp Ile Leu Gln Tyr Ser Glu Pro Gln Ser Arg Phe Trp
    290                 295                 300
Gly Arg Asp Lys Asn Val Pro Thr Ile Gly Val Ile Ala Val Val Leu
305                 310                 315                 320
Ala Thr His Leu Cys Asp Glu Val Ser Leu Ala Gly Phe Gly Tyr Asp
                325                 330                 335
Leu Asn Gln Pro Lys Thr Pro Leu His Tyr Phe Asp Asn Leu Cys Met
            340                 345                 350
Ala Ala Met Asn Phe Gln Thr Met His Asn Val Thr Thr Glu Thr Arg
        355                 360                 365
Phe Leu Leu Lys Leu Val Lys Glu Gly Val Val Lys Asp Leu Ser Gly
    370                 375                 380
Gly Ile His Cys Glu Phe
385                 390

<210> 15
<211> 3159
<212> DNA
<213> Canis familiaris

<400> 15
ggtcgattgc cccttggctg ctgtggaggc tgtgatgacc tccagggccg cggccctccg      60
ggcgatgctt ctccaggggc tgaggccaac gcagaactcc cgtggcaccc actcggactc     120
gcggcgtgtt cacatgtggg gttttattaa atcctcccac caaccgtgtg agacaggaac     180
agttagcccc ggtgtgtccg ccaagattgc cccgcacaag tggctccgga tggatcacac     240
gaagcacttg caagtgaaga agcagcacag ccctttatct tgggctattt cctgtggaga     300
gactccaaca atttagcagc caggctcctg ggcctctggg accctcacca catcacatcc     360
ttcaccttca ggagcagagc gcctttggga aacagacttc taaaagtgca ggtgggccag     420
ccatgagagg gtacctagtg gccatattcc tgagtgctgt ctttctctat tatgtgctgc     480
attgtatatt gtggggaaca aacatctatt gggtgccacc tgtggaaatg aagcggagaa     540
ataagatcca gccttgttta gcgaagccag cttttgcctc tctcctgagg tttcatcagt     600
ttcacccttt tctgtgtgca gctgatttta aaaagattgc ttccttgtat ggtagcgata     660
agtttgatct gccctatggg ataagaacat cagcggaata ttttcgactc gctctttcaa     720
aactgcagag ttgtgatctc tttgatgagt ttgacaatgt gccgtgtaaa aagtgcgtgg     780
tggttggtaa tggaggagtt ctgaagaata agacattagg agaaaaaatt gactcctatg     840
atgtcataat aagaatgaat aatggtcctg ttttaggaca tgaagaggaa gttgggagaa     900
ggacaacctt ccgacttttt tatccagaat ctgttttttc agatcccaat cacaatgatc     960
ctaatactac agcgattctc actgctttta agccgcttga cttaaagtgg ctgtgggaag    1020
tgttgacggg tggcaaaata aacactaatg gtttttggaa gaaaccagct ttaaacttga    1080
tctacaaacc ttatcaaatc agaatattag atcctttcat tatcagaatg gcagcttatg    1140
aactgcttca cttcccaaaa gtgtttccca aaaaccagaa acccaaacac ccaacaacag    1200
gaattattgc catcacgctg gcctttcaca tatgtcacga agttcacctt gctggtttta    1260
aatacaattt ttctgacctc aagagccctt tacactatta tgggaacgcg accatgtctt    1320
tgatgaataa gaatgcgtat cacaatgtga cagcggaaca gctctttttg aaggacattc    1380
tagaaaaaaa ctttgtaatc aacttgactg aagattgacc ctacagactc tgcagatgat    1440
gctaagagta ttagttttat ttttatactg caatttttag tttattttta aatatgttgg    1500
atgcacttgt caaaaaattg tgtatagtca gtctgttgct gcctggtgat tcataaccac    1560
cagcttaatt tctgtgaata tatttaattt ataaaaacca agaagatatg cttagatatc    1620
cgggaagttt tgattgcgtt ggttttaaaa caaccttagt tctctgaagt gtttttaaac    1680
atctttttta atagttactt catctttgac ttctgagggc atgtgacgtc caagtaaggg    1740
gctttagctt gaccaccaca aactctgaac agagttggtg gcggattcgg ctactgtaaa    1800
ttggtgggga atagccatgt gattgtgcaa actggaaccg gtttaggcaa gtatcgagtt    1860
cctttttact gaacccgagg aaacggattt gaatcttaaa gcaggcccaa ccatagcagt    1920
aggtacggtt atgaaatcta agatcataat ggtttcatta agcttttttt cctgtaagta    1980
aaccagatta taaaatgaaa ggtgtttgtt tttaaggtgg aggaaacagg ctacatgtga    2040
aattctggat gagtaaacaa cctaggaatg caattactaa agtctggtgg ctgcattatt    2100
ttaaagttca tacaaagaag cagagctagg ccacctcaag gagacagttc ttaaacgtca    2160
tcttttgcct gccttaatat gttaaaattt ggaagtttac tatttgaaat aggaaagatg    2220
aatacggcac agtaggtaaa tccttcagac tcctcaggct gtttttggat ttaaatggtc    2280
ctttcgtgaa aaatctcact tgtccacggt gaaatcccat cttcaaaggg aaggcttacc    2340
cggctaccta gggtgcatca gagaagagtc ctgctggatg cagacaagtc aaaaccagcc    2400
tgtccaacaa acgtgcgccc gtctctcttc tcaaagaggg atggaatgaa cagctctcag    2460
aagaggtaag agttgaagga cttgttatcc tctgagcgat aatcgtcatg gagagacact    2520
gctggtgttc ctgaaaacca gcctgcctct gagtctcaga gacaaaatat gagagcagcc    2580
actgggataa atcgtgaagc acggcataag gggggagaag cctcgtagtt gattgaaccc    2640
atgtctacgt ggcttcagct gattcccctg taacggaggt ggaaagttcc cgcacgtaca    2700
cagctgcacg ctgcagcctg gcggctggga ttccatgggt ggactcattc agggtacaaa    2760
gacagtcctg gctgcaaagt gaaaaacccc aggtggcatt ttcaagtgtt tatggactga    2820
aataatggct gtacggtatc tggcggatgc tcaacttgag gaatcggcat ttttgtacag    2880
tgggagctga ggctataaac ctcagcgtgg cttcacataa gccagaagaa actctcagcc    2940
cgatacatat gtacaattta ttaaaaacac atgaacacgt taaaatctca ctatttatac    3000
aatctacatt ctagcaacat atacaaatac cgagtgacta cagtacatgc cgaggtaaga    3060
aaagtacatt cggggagact atcactgaca ctcaagccat ttttatttcc aatatgtttt    3120
gctttcacct ttcccagtgc caaaaaaaaa aaaaaaaaa                           3159

<210> 16
<211> 331
<212> PRT
<213> Canis familiaris

<400> 16
Met Arg Gly Tyr Leu Val Ala Ile Phe Leu Ser Ala Val Phe Leu Tyr
 1               5                  10                  15
Tyr Val Leu His Cys Ile Leu Trp Gly Thr Asn Ile Tyr Trp Val Pro
            20                  25                  30
Pro Val Glu Met Lys Arg Arg Asn Lys Ile Gln Pro Cys Leu Ala Lys
        35                  40                  45
Pro Ala Phe Ala Ser Leu Leu Arg Phe His Gln Phe His Pro Phe Leu
    50                  55                  60
Cys Ala Ala Asp Phe Lys Lys Ile Ala Ser Leu Tyr Gly Ser Asp Lys
65                  70                  75                  80
Phe Asp Leu Pro Tyr Gly Ile Arg Thr Ser Ala Glu Tyr Phe Arg Leu
                85                  90                  95
Ala Leu Ser Lys Leu Gln Ser Cys Asp Leu Phe Asp Glu Phe Asp Asn
            100                 105                 110
Val Pro Cys Lys Lys Cys Val Val Val Gly Asn Gly Gly Val Leu Lys
        115                 120                 125
Asn Lys Thr Leu Gly Glu Lys Ile Asp Ser Tyr Asp Val Ile Ile Arg
    130                 135                 140
Met Asn Asn Gly Pro Val Leu Gly His Glu Glu Glu Val Gly Arg Arg
145                 150                 155                 160
Thr Thr Phe Arg Leu Phe Tyr Pro Glu Ser Val Phe Ser Asp Pro Asn
                165                 170                 175
His Asn Asp Pro Asn Thr Thr Ala Ile Leu Thr Ala Phe Lys Pro Leu
            180                 185                 190
Asp Leu Lys Trp Leu Trp Glu Val Leu Thr Gly Gly Lys Ile Asn Thr
        195                 200                 205
Asn Gly Phe Trp Lys Lys Pro Ala Leu Asn Leu Ile Tyr Lys Pro Tyr
    210                 215                 220
Gln Ile Arg Ile Leu Asp Pro Phe Ile Ile Arg Met Ala Ala Tyr Glu
225                 230                 235                 240
Leu Leu His Phe Pro Lys Val Phe Pro Lys Asn Gln Lys Pro Lys His
                245                 250                 255
Pro Thr Thr Gly Ile Ile Ala Ile Thr Leu Ala Phe His Ile Cys His
            260                 265                 270
Glu Val His Leu Ala Gly Phe Lys Tyr Asn Phe Ser Asp Leu Lys Ser
        275                 280                 285
Pro Leu His Tyr Tyr Gly Asn Ala Thr Met Ser Leu Met Asn Lys Asn
    290                 295                 300
Ala Tyr His Asn Val Thr Ala Glu Gln Leu Phe Leu Lys Asp Ile Leu
305                 310                 315                 320
Glu Lys Asn Phe Val Ile Asn Leu Thr Glu Asp
                325                 330

<210> 17
<211> 1337
<212> DNA
<213> Canis familiaris

<400> 17
aaagacttca ctgggtatca gtctcctttg ggagaccaca ggacacgtgt cacctctccc      60
atcctctcag cctccagccc agaccttggc agagttcctt ttaggagtta gcaagtggct     120
gaggaggcaa gaggtgccag agccaatcta ctatctgctg ggggatgatt gccagggcca     180
gagatgaggg ctcaatactt gaagtggggt ctggtagctg cctgtatagt tacgttatgg     240
ctgatgatga tgaacttcct ggaccaggag ttcaaacaga atgacttccc taaaaagaca     300
agaatacaat tatgccactg ccccaggaac tctttcagaa agtgtaggtg ttcgtttgag     360
atccgcaagt gctctgcctg cctccgcgta cgtggaacgt ctgtctggtt tgatgaacgc     420
ttcgaaacgg ctattgagcc tgtgcagaga ccagaagatc ccatatcctc tgatgctctg     480
atattgtggt tgggtgtcca atcaaagagg gagtttgaga ctcagaagcc aatagaagag     540
cctcctgggc aaccactggg ctacgtggag tccagttgtc ggacctgtgc agtggttgga     600
aactcaaggt gcctacgggg ctctggccat ggattcagga ttaaccaaaa tgacatggtc     660
ctcaggatga accaggcccc cgtccaagga tttgagatgg atgtggggaa cacaaccacc     720
atgcgcataa tgtaccccga tatggctagc acgcagaatc ctggcaccaa attgctgctg     780
cttcctctga attcatctgg tctaaagtgg tttatggaag tactacagga acagagcttc     840
agaaagccca taaaccctgg atttcagata gtccagtttc ctggtggaag taacacgagc     900
aaagacgagg tcttggtgat cagcctcacc tttcttcagt acatccagga tcattggctg     960
cgaaaacgtc atcgttttcc atccttgggg tttgtgggtc tgttatatgc cctgcacact    1020
tgtgaccagg tatccttatt tggttttggg acagatcagc tcatgaggtg gtcccattac    1080
tgggatgata aatatcggtt cgagagtaac atgcacagtt tcaaagaaga gcagaagctc    1140
atcctccagc tgcaatgtga ggggaagatt gttatctaca gctgacatgt ttctgtcctg    1200
ttcagcccac tggaggcccc aggaggctga caggtagtca aggggaccac agagtgtcag    1260
agagggactg gggcttcaag tggaccctgg atatagatca gtctgctgct aaataaaact    1320
acagcttatt tctccca                                                   1337

<210> 18
<211> 333
<212> PRT
<213> Canis familiaris

<400> 18
Met Arg Ala Gln Tyr Leu Lys Trp Gly Leu Val Ala Ala Cys Ile Val
 1               5                  10                  15
Thr Leu Trp Leu Met Met Met Asn Phe Leu Asp Gln Glu Phe Lys Gln
            20                  25                  30
Asn Asp Phe Pro Lys Lys Thr Arg Ile Gln Leu Cys His Cys Pro Arg
        35                  40                  45
Asn Ser Phe Arg Lys Cys Arg Cys Ser Phe Glu Ile Arg Lys Cys Ser
    50                  55                  60
Ala Cys Leu Arg Val Arg Gly Thr Ser Val Trp Phe Asp Glu Arg Phe
65                  70                  75                  80
Glu Thr Ala Ile Glu Pro Val Gln Arg Pro Glu Asp Pro Ile Ser Ser
                85                  90                  95
Asp Ala Leu Ile Leu Trp Leu Gly Val Gln Ser Lys Arg Glu Phe Glu
            100                 105                 110
Thr Gln Lys Pro Ile Glu Glu Pro Pro Gly Gln Pro Leu Gly Tyr Val
        115                 120                 125
Glu Ser Ser Cys Arg Thr Cys Ala Val Val Gly Asn Ser Arg Cys Leu
    130                 135                 140
Arg Gly Ser Gly His Gly Phe Arg Ile Asn Gln Asn Asp Met Val Leu
145                 150                 155                 160
Arg Met Asn Gln Ala Pro Val Gln Gly Phe Glu Met Asp Val Gly Asn
                165                 170                 175
Thr Thr Thr Met Arg Ile Met Tyr Pro Asp Met Ala Ser Thr Gln Asn
            180                 185                 190
Pro Gly Thr Lys Leu Leu Leu Leu Pro Leu Asn Ser Ser Gly Leu Lys
        195                 200                 205
Trp Phe Met Glu Val Leu Gln Glu Gln Ser Phe Arg Lys Pro Ile Asn
    210                 215                 220
Pro Gly Phe Gln Ile Val Gln Phe Pro Gly Gly Ser Asn Thr Ser Lys
225                 230                 235                 240
Asp Glu Val Leu Val Ile Ser Leu Thr Phe Leu Gln Tyr Ile Gln Asp
                245                 250                 255
His Trp Leu Arg Lys Arg His Arg Phe Pro Ser Leu Gly Phe Val Gly
            260                 265                 270
Leu Leu Tyr Ala Leu His Thr Cys Asp Gln Val Ser Leu Phe Gly Phe
        275                 280                 285
Gly Thr Asp Gln Leu Met Arg Trp Ser His Tyr Trp Asp Asp Lys Tyr
    290                 295                 300
Arg Phe Glu Ser Asn Met His Ser Phe Lys Glu Glu Gln Lys Leu Ile
305                 310                 315                 320
Leu Gln Leu Gln Cys Glu Gly Lys Ile Val Ile Tyr Ser
                325                 330

<210> 19

<400> 19
 000

<210> 20
<211> 83
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 20
cctccttctt cctgaattac tcccacaccc ctccttttct gaattactcc cacacccctc      60
ctttcctgaa ttactcccac acc                                              83

<210> 21
<211> 59
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 21
ctttacctac tcccaccaca gcatggccac tttacctact cccaccacaa gcatggcca       59

<210> 22
<211> 87
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 22
ctcccccgcg gctgtggcgg ccgcccgcgc tcccccgcgg gctgtggcgg ccgcccgcgc      60
tcccccgcgc tgtggcggcc gcccgcg                                          87

<210> 23
<211> 319
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 23
tccccaggaa ccctgctacc ctctgagaat ccccaggacc ctgctaccct ctgagaatcc      60
ccaggacgat ggtggtgtca aagtacttga aggcggcagg ggctcccaga ttggtcaggg     120
taaacaggtg gatgatattc tcggcctgct ctctgatggg cttatcccgg tgcttgttgt     180
aggcggacag cactttgtcc agattagcgt cggccaggat cactctcttg gagaactcgc     240
tgatctgctc gatgatctcg tccaggtagt gcttgtgctg ttccacaaac agctgtttca     300
ccctgctacc ctctgagaa                                                  319

<210> 24
<211> 135
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 24
atcgctcaag accctctctg caatggtaca tcgctcaaga ccctctctga tggtacatcg      60
ctcaagacca atggtacatc gctcaagacc ctctctggca atggtacatc gctcaagacc     120
ctctctcaat ggtac                                                      135

<210> 25
<211> 59
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 25
agcgataagt ttgatctgcc ctatgggata agcgataagt ttgatctgcc tatgggata       59

<210> 26
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 26
gcccccgtcc aaggatttga gatggatgtg cccccgtcaa ggatttgaga tggatgt         57

<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 27
ccctcctcgt cctcttcatc                                                  20

<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 28
aggcagagag agaccagaga                                                  20

<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 29
ccaaaccatg aagtgctccc                                                  20

<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 30
aggggcttga agagtgactc                                                  20

<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 31
atgagacttg cttgcatccc                                                  20

<210> 32
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 32
ctttggttgg cctctctgtc tc                                               22

<210> 33
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 33
cgttagccgc gcgcacag                                                    18

<210> 34
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 34
ccgggatgac agctctc                                                     17

<210> 35
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 35
acatggaagc tggactcac                                                   19

<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 36
catcatcaca aggatcctgc                                                  20

<210> 37
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 37
ctctcccatg aaaacctgg                                                   19

<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 38
gttttaaatt tgggagcggc c                                                21

<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 39
tggctcacat caaacaccac                                                  20

<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 40
ggttggaaac tcaaggtgcc                                                  20

<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 41
tgactccttc cccttttccc                                                  20

<210> 42
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 42
gttacgcgcc agcaaaagca ggggaaaaca aaagcaa                               37

<210> 43
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 43
gttacgcgcc agtagaaaca agggtgtttt tctcatgc                              38

<210> 44
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 44
gttacgcgcc agcaaaagca ggagtttaaa at                                    32

<210> 45
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 45
gttacgcgcc agtagaaaca aggagttttt tgaacaac                              38

<210> 46
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 46
gttacgcgcc agcaaaagca ggggataatt ctattaa                               37

<210> 47
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 47
gttacgcgcc agtagaaaca agggtgtttt taattaatg                             39

<210> 48
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 48
gttacgcgcc agcaaaagca ggagtaaaga tg                                    32

<210> 49
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 49
gttacgcgcc agtagaaaca aggagttttt tctaaaattg c                          41

<210> 50
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 50
gttacgcgcc agcagaagca gagcattttc taatatcc                              38

<210> 51
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 51
gttacgcgcc agtagtaaca agagcatttt tcaataacgt ttc                        43

<210> 52
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 52
gttacgcgcc agcagaagca gagcatcttc tcaaaactg                             39

<210> 53
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 53
gttacgcgcc agtagtaaca agagcatttt tcagaaac                              38

<210> 54
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 54
agaaaagaat gtaacagtaa cacactctgt                                       30

<210> 55
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 55
tgtttccaca atgtargacc at                                               22

<210> 56
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 56
ctattggaca atagtaaaac cgggrga                                          27

<210> 57
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 57
gtcattgggr atgcttccat ttgg                                             24

<210> 58

<400> 58
 000

<210> 59
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 59
cctgttacat ctgggtgctt tcctataatg                                       30

<210> 60
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 60
gttgatarcc tgatatgttc gtatcctckg                                       30

<210> 61
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 61
cctgttacat ccgggtgctt ycctataatg                                       30

<210> 62
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 62
gttgataacc tkatmttttc atatcctctg                                       30

<210> 63
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 63
ccmaggtcga aacgtaygtt ctctctatc                                        29

<210> 64
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 64
tgacagraty ggtcttgtct ttagccaytc ca                                    32

<210> 65
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 65
ggagcaacca atgccac                                                     17

<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 66
gtktaggcgg tcttgaccag                                                  20

<210> 67
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 67
cagccagcaa trttrcattt acc                                              23

<210> 68
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 68
cagccagcaa trttrcattt acc                                              23

<210> 69
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 69
aagtaacccc kaggagcaat tag                                              23

<210> 70
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 70
aagtaacccc kaggagcaat tag                                              23

<210> 71
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 71
ttagacagct gcctaacc                                                    18

<210> 72
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 72
ttagacagct gcctaacc                                                    18

<210> 73
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 73
tcaggcaact asccaatc                                                    18

<210> 74
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 74
tcaggcaact asccaatc                                                    18

<210> 75
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 75
atytcggctt tgagggggcc tg                                               22

<210> 76
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic oligonucleotide

<400> 76
ataaactttg aagcaggaat                                                  20

<210> 77

<400> 77
 000

<210> 78

<400> 78
 000

<210> 79

<400> 79
 000

<210> 80

<400> 80
 000

<210> 81

<400> 81
 000

<210> 82

<400> 82
 000

<210> 83

<400> 83
 000

<210> 84

<400> 84
 000

<210> 85

<400> 85
 000

<210> 86

<400> 86
 000

<210> 87

<400> 87
 000

<210> 88

<400> 88
 000

<210> 89

<400> 89
 000

<210> 90

<400> 90
 000

<210> 91

<400> 91
 000

<210> 92

<400> 92
 000

<210> 93

<400> 93
 000

<210> 94

<400> 94
 000

<210> 95

<400> 95
 000

<210> 96

<400> 96
 000

<210> 97

<400> 97
 000

<210> 98

<400> 98
 000

<210> 99

<400> 99
 000

<210> 100
<211> 1221
<212> DNA
<213> Homo sapiens

<400> 100
atgattcaca ccaacctgaa gaaaaagttc agctgctgcg tcctggtctt tcttctgttt      60
gcagtcatct gtgtgtggaa ggagaagaag aaagggagtt actatgattc ctttaaattg     120
caaaccaagg aattccaggt gttaaagagt ctggggaaat tggccatggg gtctgattcc     180
cagtctgtat cctcaagcag cacccaggac ccccacaggg gccgccagac cctcggcagt     240
ctcagaggcc tagccaaggc caaaccagag gcctccttcc aggtgtggaa caaggacagc     300
tcttccaaaa accttatccc taggctgcaa aagatctgga agaattacct aagcatgaac     360
aagtacaaag tgtcctacaa ggggccagga ccaggcatca agttcagtgc agaggccctg     420
cgctgccacc tccgggacca tgtgaatgta tccatggtag aggtcacaga ttttcccttc     480
aatacctctg aatgggaggg ttatctgccc aaggagagca ttaggaccaa ggctgggcct     540
tggggcaggt gtgctgttgt gtcgtcagcg ggatctctga agtcctccca actaggcaga     600
gaaatcgatg atcatgacgc agtcctgagg tttaatgggg cacccacagc caacttccaa     660
caagatgtgg gcacaaaaac taccattcgc ctgatgaact ctcagttggt taccacagag     720
aagcgcttcc tcaaagacag tttgtacaat gaaggaatcc taattgtatg ggacccatct     780
gtataccacc cagatatccc aaagtggtac cagaatccgg attataattt ctttaacaac     840
tacaagactt atcgtaagct gcaccccaat cagccctttt acatcctcaa gccccagatg     900
ccttgggagc tatgggacat tcttcaagaa atctccccag aagagattca gccaaacccc     960
ccatcctctg ggatgcttgg tatcatcatc atgatgacgc tgtgtgacca ggtggatatt    1020
tatgagttcc tcccatccaa gcgcaggact gacgtgtgct actactacca gaagttcttc    1080
gatagtgcct gcacgatggg tgcctaccac ccgctgctct ttgagaagaa tttggtgaag    1140
catctcaacc agggcacaga tgaggacatc tacctgcttg gaaaagccac actgcctggc    1200
ttccggacca ttcactgcta a                                              1221

<210> 101
<211> 406
<212> PRT
<213> Homo sapiens

<400> 101
Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val
 1               5                  10                  15
Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly
            20                  25                  30
Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu
        35                  40                  45
Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser
    50                  55                  60
Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser
65                  70                  75                  80
Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp
                85                  90                  95
Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile
            100                 105                 110
Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly
        115                 120                 125
Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu
    130                 135                 140
Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe
145                 150                 155                 160
Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr
                165                 170                 175
Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser
            180                 185                 190
Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val
        195                 200                 205
Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly
    210                 215                 220
Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu
225                 230                 235                 240
Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val
                245                 250                 255
Trp Asp Pro Ser Val Tyr His Pro Asp Ile Pro Lys Trp Tyr Gln Asn
            260                 265                 270
Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His
        275                 280                 285
Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu
    290                 295                 300
Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro
305                 310                 315                 320
Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp
                325                 330                 335
Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Arg Thr Asp Val
            340                 345                 350
Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala
        355                 360                 365
Tyr His Pro Leu Leu Phe Glu Lys Asn Leu Val Lys His Leu Asn Gln
    370                 375                 380
Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly
385                 390                 395                 400
Phe Arg Thr Ile His Cys
                405

<210> 102

<400> 102
 000

<210> 103

<400> 103
 000

<210> 104

<400> 104
 000

<210> 105

<400> 105
 000

<210> 106

<400> 106
 000

<210> 107

<400> 107
 000

<210> 108

<400> 108
 000

<210> 109

<400> 109
 000

<210> 110

<400> 110
 000

<210> 111

<400> 111
 000

<210> 112

<400> 112
 000

<210> 113

<400> 113
 000

<210> 114

<400> 114
 000

<210> 115

<400> 115
 000

<210> 116

<400> 116
 000

<210> 117

<400> 117
 000

<210> 118

<400> 118
 000

<210> 119

<400> 119
 000

<210> 120

<400> 120
 000

<210> 121

<400> 121
 000

<210> 122

<400> 122
 000

<210> 123

<400> 123
 000

<210> 124

<400> 124
 000

<210> 125

<400> 125
 000

<210> 126

<400> 126
 000

<210> 127

<400> 127
 000

<210> 128

<400> 128
 000

<210> 129

<400> 129
 000

<210> 130

<400> 130
 000

<210> 131

<400> 131
 000

<210> 132

<400> 132
 000

<210> 133

<400> 133
 000

<210> 134

<400> 134
 000

<210> 135

<400> 135
 000

<210> 136

<400> 136
 000

<210> 137

<400> 137
 000

<210> 138

<400> 138
 000

<210> 139

<400> 139
 000

<210> 140

<400> 140
 000

<210> 141

<400> 141
 000

<210> 142

<400> 142
 000

<210> 143

<400> 143
 000

<210> 144

<400> 144
 000

<210> 145

<400> 145
 000

<210> 146

<400> 146
 000

<210> 147

<400> 147
 000

<210> 148

<400> 148
 000

<210> 149

<400> 149
 000

<210> 150
<211> 406
<212> PRT
<213> Homo sapiens

<400> 150
Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val
 1               5                  10                  15
Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly
            20                  25                  30
Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu
        35                  40                  45
Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser
    50                  55                  60
Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser
65                  70                  75                  80
Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp
                85                  90                  95
Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile
            100                 105                 110
Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly
        115                 120                 125
Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu
    130                 135                 140
Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe
145                 150                 155                 160
Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr
                165                 170                 175
Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser
            180                 185                 190
Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val
        195                 200                 205
Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly
    210                 215                 220
Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu
225                 230                 235                 240
Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val
                245                 250                 255
Trp Asp Pro Ser Val Tyr His Pro Asp Ile Pro Lys Trp Tyr Gln Asn
            260                 265                 270
Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His
        275                 280                 285
Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu
    290                 295                 300
Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro
305                 310                 315                 320
Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp
                325                 330                 335
Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Arg Thr Asp Val
            340                 345                 350
Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala
        355                 360                 365
Tyr His Pro Leu Leu Phe Glu Lys Asn Leu Val Lys His Leu Asn Gln
    370                 375                 380
Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly
385                 390                 395                 400
Phe Arg Thr Ile His Cys
                405

<210> 151
<211> 1221
<212> DNA
<213> Homo sapiens

<400> 151
atgattcaca ccaacctgaa gaaaaagttc agctgctgcg tcctggtctt tcttctgttt      60
gcagtcatct gtgtgtggaa ggagaagaag aaagggagtt actatgattc ctttaaattg     120
caaaccaagg aattccaggt gttaaagagt ctggggaaat tggccatggg gtctgattcc     180
cagtctgtat cctcaagcag cacccaggac ccccacaggg gccgccagac cctcggcagt     240
ctcagaggcc tagccaaggc caaaccagag gcctccttcc aggtgtggaa caaggacagc     300
tcttccaaaa accttatccc taggctgcaa aagatctgga agaattacct aagcatgaac     360
aagtacaaag tgtcctacaa ggggccagga ccaggcatca agttcagtgc agaggccctg     420
cgctgccacc tccgggacca tgtgaatgta tccatggtag aggtcacaga ttttcccttc     480
aatacctctg aatgggaggg ttatctgccc aaggagagca ttaggaccaa ggctgggcct     540
tggggcaggt gtgctgttgt gtcgtcagcg ggatctctga agtcctccca actaggcaga     600
gaaatcgatg atcatgacgc agtcctgagg tttaatgggg cacccacagc caacttccaa     660
caagatgtgg gcacaaaaac taccattcgc ctgatgaact ctcagttggt taccacagag     720
aagcgcttcc tcaaagacag tttgtacaat gaaggaatcc taattgtatg ggacccatct     780
gtataccacc cagatatccc aaagtggtac cagaatccgg attataattt ctttaacaac     840
tacaagactt atcgtaagct gcaccccaat cagccctttt acatcctcaa gccccagatg     900
ccttgggagc tatgggacat tcttcaagaa atctccccag aagagattca gccaaacccc     960
ccatcctctg ggatgcttgg tatcatcatc atgatgacgc tgtgtgacca ggtggatatt    1020
tatgagttcc tcccatccaa gcgcaggact gacgtgtgct actactacca gaagttcttc    1080
gatagtgcct gcacgatggg tgcctaccac ccgctgctct ttgagaagaa tttggtgaag    1140
catctcaacc agggcacaga tgaggacatc tacctgcttg gaaaagccac actgcctggc    1200
ttccggacca ttcactgcta a                                              1221
