                         SEQUENCE LISTING

<110>  PORTAGE GLASGOW LIMITED
       MARCOUX, Frank W. et al.
 
<120>  STRUCTURE, MANUFACTURING AND USES OF HOXD12-PDE8A 
       CELL-PENETRATING PEPTIDES

<130>  130268-8001.WO00

<150>  US 62/803,123
<151>  2019-02-08

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HOX-D12-derived peptide

<400>  1

Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val 
    50                  55                  60  


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: PDE8A-derived peptide

<400>  2

Arg Arg Leu Ser Gly Asn Glu Tyr Val Leu Ser Thr 
1               5                   10          


<210>  3
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HOX-D12  PDE8A conjugate

<400>  3

Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Arg Arg Leu Ser 
    50                  55                  60                  


Gly Asn Glu Tyr Val Leu Ser Thr 
65                  70          


<210>  4
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HOX-C12-derived peptide

<400>  4

Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu Gln Leu Ala Glu Leu 
1               5                   10                  15      


Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr Arg Gln Arg Arg Arg 
            20                  25                  30          


Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu Leu 
    50                  55                  60  


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (6)..(20)
<223>  "Gly Gly Gly Gly S" may or may not be present

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Gly may or may not be present

<400>  6

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (6)..(15)
<223>  "Glu Ala Ala Ala Lys" may or may not be present

<400>  7

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  8
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  8

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  9

Pro Ala Pro Ala Pro 
1               5   


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  10

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  11
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (21)..(68)
<223>  "Ala Pro" may or may not be present

<400>  11

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
    50                  55                  60                  


Ala Pro Ala Pro 
65              


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Cleavable at this location

<400>  12

Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp 
1               5                   10                  15      


Val 
    


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Cleavable at this location

<400>  13

Pro Leu Gly Leu Trp Ala Cys 
1               5           


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Cleavable at this location

<400>  14

Arg Val Leu Ala Glu Ala 
1               5       


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Cleavable at this location

<400>  15

Glu Asp Val Val Cys Cys Ser Met Ser Tyr 
1               5                   10  


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Cleavable at this location

<400>  16

Gly Gly Ile Glu Gly Arg Gly Ser 
1               5               


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Cleavable at this location

<400>  17

Thr Arg His Arg Gln Pro Arg Gly Trp Glu 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Cleavable at this location

<400>  18

Ala Gly Asn Arg Val Arg Arg Ser Val Gly 
1               5                   10  


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Cleavable at this location

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Cleavable at this location

<400>  19

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Cleavable at this location

<400>  20

Gly Phe Leu Gly 
1               


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: PDE8A  C-Raf Disruptor Peptide

<400>  21

Arg Arg Leu Ser Gly Asn Glu Tyr Val Leu Ser Thr 
1               5                   10          


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Scrambled Peptide

<400>  22

Ser Tyr Thr Val Arg Leu Leu Gly Glu Arg Asn Ser 
1               5                   10          


<210>  23
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Unknown Organism

<400>  23

Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Cys 
    50                  55                  60      


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Unknown Organism

<400>  24

Arg Arg Leu Ser Gly Asn Glu Tyr Val Leu Ser Thr Cys 
1               5                   10              


<210>  25
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Unknown Organism

<400>  25

Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val Cys 
    50                  55                  60      


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Unknown Organism


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 6-aminohexanoic acid (Aha)

<400>  26

Arg Arg Leu Ser Gly Asn Glu Tyr Val Leu Ser Thr Xaa Lys 
1               5                   10                  


<210>  27
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Unknown Organism

<400>  27

Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val 
    50                  55                  60  


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Unknown Organism

<400>  28

Arg Arg Leu Ser Gly Asn Glu Tyr Val Leu Ser Thr Cys 
1               5                   10              


<210>  29
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Unknown Organism

<400>  29

Ala Arg Lys Lys Arg Lys Pro Tyr Thr Lys Gln Gln Ile Ala Glu Leu 
1               5                   10                  15      


Glu Asn Glu Phe Leu Val Asn Glu Phe Ile Asn Arg Gln Lys Arg Lys 
            20                  25                  30          


Glu Leu Ser Asn Arg Leu Asn Leu Ser Asp Gln Gln Val Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Val Val 
    50                  55                  60  


<210>  30
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Unknown Organism


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = 6-aminohexanoic acid (Aha)

<400>  30

Arg Arg Leu Ser Gly Asn Glu Tyr Val Leu Ser Thr Xaa Lys 
1               5                   10                  


