                         SEQUENCE LISTING

<110>  ARROWHEAD PHARMACEUTICALS, INC.
       Janssen Pharmaceuticals, Inc.

<120>  RNAi Agents for Hepatitis B Virus Infection

<130>  16500-20005.40

<140>  Concurrently Herewith
<141>  Not Yet Assigned

<150>  US 62/932,315
<151>  2019-11-07

<150>  US 62/853,659
<151>  2019-05-28

<150>  US 62/802,614
<151>  2019-02-07

<160>  334

<210>  1
<211>  3221
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hepatitis B virus (subtype ADW2), genotype A, 
complete gene (AM282986.1)

<400> 1
ttccactgcc ttccaccaag ctctgcagga tcccaaagtc aggggtctgt attttcctgc 60
tggtggctcc agttcaggaa cagtaaaccc tgctccgaat attgcctctc acatctcgtc 120
aatctccgcg aggactgggg accctgtgac gaatatggag aacatcacat caggattcct 180
aggacccctg ctcgtgttac aggcggggtt tttcttgttg acaagaatcc tcacaatacc 240
gcagagtcta gactcgtggt ggacttctct caattttcta gggggatcac ccgtgtgtct 300
tggccaaaat tcgcagtccc caacctccaa tcactcacca acctcctgtc ctccaatttg 360
tcctggttat cgctggatgt gtctgcggcg ttttatcata ttcctcttca tcctgctgct 420
atgcctcatc ttcttgttgg ttcttctgga ttatcaaggt atgttgcccg tttgtcctct 480
aattccagga acaacaacaa ccagtacggg accatgcaaa acctgcacga ctcctgctca 540
aggcaactct atgtttccct catgttgctg tacaaaacct tcggatggaa attgcacctg 600
tattcccatc ccatcgtctt gggctttcgc aaaataccta tgggagtggg cctcagtccg 660
tttctcttgg ctcagtttac tagtgccatt tgttcagtgg ttcgtagggc tttcccccac 720
tgtttggctt tcagctatat ggatgatgtg gtattggggg ccaagtctgt acagcatcgt 780
gagtcccttt ataccgctgt taccaatttt cttttgtctc tgggtataca tttaaaccct 840
aacaaaacaa aaagatgggg ttattcccta aacttcatgg gttacataat tggaagttgg 900
ggaacgttgc cacaggatca tattgtacaa aagatcaaac actgttttag aaaacttcct 960
gttaacaggc ctattgattg gaaagtatgt caaagaattg tgggtctttt gggctttgct 1020
gctccattta cacaatgtgg atatcctgcc ttaatgcctt tgtatgcctg tatacaagct 1080
aaacaggctt tcactttctc gccaacttac aaggcctttc taagtaaaca gtacatgaac 1140
ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga cgcaaccccc 1200
actggctggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt ggctcctctg 1260
ccgatccata ctgcggaact cctagccgct tgttttgctc gcagccggtc tggggcaaag 1320
ctcatcggaa ctgacaattc tgtcgtcctc tcgcggaaat atacatcgtt tccatggctg 1380
ctaggttgta ctgccaactg gatccttcgc gggacgtcct ttgtttacgt cccgtcggcg 1440
ctgaatcccg cggacgaccc ctctcggggc cgcttgggac tctctcgtcc ccttctccgt 1500
ctgccgttcc agccgaccac ggggcgcacc tctctttacg cggtctcccc gtctgtgcct 1560
tctcatctgc cggtccgtgt gcacttcgct tcacctctgc acgttgcatg gagaccaccg 1620
tgaacgccca tcagatcctg cccaaggtct tacataagag gactcttgga ctcccagcaa 1680
tgtcaacgac cgaccttgag gcctacttca aagactgtgt gtttaaggac tgggaggagc 1740
tgggggagga gattaggtta aaggtctttg tattaggagg ctgtaggcat aaattggtct 1800
gcgcaccagc accatgcaac tttttcacct ctgcctaatc atctcttgta catgtcccac 1860
tgttcaagcc tccaagctgt gccttgggtg gctttggggc atggacattg acccttataa 1920
agaatttgga gctactgtgg agttactctc gtttttgcct tctgactttt ttccttccgt 1980
cagagatctc ctagacaccg cctcagctct gtatcgggaa gccttagagt ctcctgagca 2040
ttgctcacct caccatactg cactcaggca agcaattctc tgctgggggg aattgatgac 2100
tctagctacc tgggtgggta ataatttgga agatccagca tccagggatc tagtagtcaa 2160
ttatgttaat actaacatgg gtttaaagat caggcaacta ttgtggtttc atatatcttg 2220
ccttactttt ggaagagaga ctgtacttga atatttggtc tctttcggag tgtggattcg 2280
cactcctcca gcctatagac caccaaatgc ccctatctta tcaacacttc cggaaactac 2340
tgttgttaga cgacgggacc gaggcaggtc ccctagaaga agaactccct cgcctcgcag 2400
acgcagatct caatcgccgc gtcgcagaag atctcaatct cgggaatctc aatgttagta 2460
ttccttggac tcataaggtg ggaaacttta ctgggcttta ttcctctaca gtacctatct 2520
ttaatcctga atggcaaact ccttcctttc ctaagattca tttacaagag gacattatta 2580
ataggtgtca acaatttgtg ggccctctca ctgtaaatga aaagagaaga ttgaaattaa 2640
ttatgcctgc tagattctat cctacccaca ctaaatattt gcccttagac aaaggaatta 2700
aaccttatta tccagatcag gtagttaatc attacttcaa aaccagacat tatttacata 2760
ctctttggaa ggctggtatt ctatataaga gggaaaccac acgtagcgca tcattttgcg 2820
ggtcaccata ttcttgggaa caagagctac agcatgggag gttggtcatc gaaacctcgc 2880
aaaggcatgg ggacgaatct ttctgttccc aaccctctgg gattctttcc cgatcatcag 2940
ttggaccctg cattcggagc caactcaaac aatccagatt gggacttcaa ccccatcaag 3000
gaccactggc cagcagccaa ccaggtagga gtgggagcat tcgggccagg gttcacccct 3060
ccacacggcg gtgttttggg gtggagccct caggctcagg gcatattgac cacagtgtca 3120
acaattcctc ctcctgcctc caccaatcgg cagtcaggaa ggcagcctac tcccatctct 3180
ccacctctaa gagacagtca tcctcaggcc atgcagtgga a                     3221


<210>  2
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV cDNA target sequence

<400>  2
gtggtggact tctctcaat                                                19


<210>  3
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV cDNA target sequence

<400>  3
tggtggactt ctctcaatt                                                19


<210>  4
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>  
<223>  HBV cDNA target sequence

<400>  4
ggacttctct caattttct                                                19


<210>  5
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>  
<223>  HBV cDNA target sequence

<400>  5
gctgtaggca taaattggt                                                19


<210>  6
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV cDNA target sequence

<400>  6
ctgtaggcat aaattggtc                                                19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  7
auugagagaa guccaccac                                                19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  8
uuugagagaa guccaccac                                                19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  9
auugagagaa guccaccan                                                19


<210>  10
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  10
uuugagagaa guccaccan                                                19


<210>  11
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  11
nuugagagaa guccaccan                                                19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  12
aauugagaga aguccacca                                                19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  13
uauugagaga aguccacca                                                19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  14
aauugagaga aguccaccn                                                19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  15
uauugagaga aguccaccn                                                19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  16
nauugagaga aguccaccn                                                19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  17
agaaaauuga gagaagucc                                                19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  18
ugaaaauuga gagaagucc                                                19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  19 
agaaaauuga gagaagucn                                                19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  20
ugaaaauuga gagaagucn                                                19


<210>  21
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  21
ngaaaauuga gagaagucn                                                19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  22
accaauuuau gccuacagc                                                19


<210>  23
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  23
uccaauuuau gccuacagc                                                19


<210>  24
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  24
accaauuuau gccuacagn                                                19


<210>  25
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  25
uccaauuuau gccuacagn                                                19


<210>  26
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  1,19
<223>  n = any nucleotide

<400>  26
nccaauuuau gccuacagn                                                19


<210>  27
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  27 
gaccaauuua ugccuacag                                                19


<210>  28
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  28 
aaccaauuua ugccuacag                                                19


<210>  29
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<400>  29
uaccaauuua ugccuacag                                                19 


<210>  30
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  30
gaccaauuua ugccuacan                                                19


<210>  31
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  31
aaccaauuua ugccuacan                                                19


<210>  32
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  32
uaccaauuua ugccuacan                                                19


<210>  33
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent antisense strand core stretch sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  33
naccaauuua ugccuacan                                                19
 

<210>  34
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  34
gugguggacu ucucucaau                                                19


<210>  35
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  35
gugguggacu ucucucaaa                                                19


<210>  36
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  36
nugguggacu ucucucaau                                                19


<210>  37
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  37
nugguggacu ucucucaaa                                                19


<210>  38
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  38
nugguggacu ucucucaan                                                19


<210>  39
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  39
ugguggacuu cucucaauu                                                19


<210>  40
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  40
ugguggacuu cucucaaua                                                19


<210>  41
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  41
ngguggacuu cucucaauu                                                19


<210>  42
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  42
ngguggacuu cucucaaua                                                19


<210>  43
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  43
ngguggacuu cucucaaun                                                19


<210>  44
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  44
ggacuucucu caauuuucu                                                19


<210>  45
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  45
ggacuucucu caauuuuca                                                19


<210>  46
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  46
ngacuucucu caauuuucu                                                19


<210>  47
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  47
ngacuucucu caauuuuca                                                19
 

<210>  48
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  48
ngacuucucu caauuuucn                                                19

<210>  49
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  49
gcuguaggca uaaauuggu                                                19


<210>  50
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  50
gcuguaggca uaaauugga                                                19


<210>  51
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  51
ncuguaggca uaaauuggu                                                19


<210>  52
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  52
ncuguaggca uaaauugga                                                19


<210>  53
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  53
ncuguaggca uaaauuggn                                                19


<210>  54
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  54
cuguaggcau aaauugguc                                                19


<210>  55
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  55
cuguaggcau aaauugguu                                                19


<210>  56
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<400>  56
cuguaggcau aaauuggua                                                19


<210>  57
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  57
nuguaggcau aaauugguc                                                19


<210>  58
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  58
nuguaggcau aaauugguu                                                19


<210>  59
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  59
nuguaggcau aaauuggua                                                19


<210>  60
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi agent sense strand core stretch sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  60
nuguaggcau aaauuggun                                                19

<210>  61
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  61
uaccaauuua ugccuacagg ccuuau                                        26


<210>  62
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  62
uaccaauuua ugccuacagg ccu                                           23

<210>  63
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  63
uaccaauuua ugccuacagg ccu                                           23

<210>  64
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  64
uaccaauuua ugccuacagg c                                             21

<210>  65
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  65
ugugaagcga agugcacacu u                                             21


<210>  66
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  66
uaccaauuua ugccuacagc cuccgc                                        26

<210>  67
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  67
uaccaauuua ugccuacagc cuccgc                                        26

<210>  68
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  68
uaccaauuua ugccuacagu u                                             21

<210>  69
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  69
uaccaauuua ugccuacagg c                                             21

<210>  70
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  70
uaccaauuua ugccuacagg c                                             21

<210>  71
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  71
uaccaauuua ugccuacagu u                                             21

<210>  72
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  72
auugagagaa guccaccacg a                                             21

<210>  73
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  73
auugagagaa guccaccacg a                                             21

<210>  74
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  74
auugagagaa guccaccacu u                                             21

<210>  75
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  75
uuugagagaa guccaccacg a                                             21

<210>  76
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  76
aauugagaga aguccaccac g                                             21


<210>  77
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  77
aauugagaga aguccaccac g                                             21


<210>  78
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  78
aauugagaga aguccaccau u                                             21


<210>  79
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  79
uauugagaga aguccaccac g                                             21 

<210>  80
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  80
uaccaauuua ugccuacagg u                                             21 

<210>  81
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  81
uaccaauuua ugccuacagu u                                             21 

<210>  82
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  82
uaccaauuua ugccuacagc c                                             21 

<210>  83
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  83
uaccaauuua ugccuacagc cuu                                           23 


<210>  84
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  84
uaccaauuua ugccuacagc cuc                                           23 

<210>  85
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  85
uaccaauuua ugccuacagc c                                             21 

<210>  86
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  86
uaccaauuua ugccuacagc cuu                                           23 

<210>  87
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  87
uaccaauuua ugccuacagc cuc                                           23

<210>  88
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  88
auugagagaa guccaccacu u                                             21 

<210>  89
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  89
uuugagagaa guccaccacu u                                             21 

<210>  90
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  90
auugagagaa guccaccacg guu                                           23

<210>  91
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  91
auugagagaa guccaccacg guu                                           23

<210>  92
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  92
auugagagaa guccaccacg agu                                           23

<210>  93
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  93
uauugagaga aguccaccac g                                             21


<210>  94
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223> HBV RNAi Agent antisense strand modified sequence

<400>  94
uauugagaga aguccaccac g                                             21

<210>  95
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  95
uauugagaga aguccaccac guu                                           23

<210>  96
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  96
uauugagaga aguccaccac gag                                           23

<210>  97
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  97
uauugagaga aguccaccac gag                                           23

<210>  98
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  98
uauugagaga aguccaccac ga                                            22

<210>  99
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  99
uauugagaga aguccaccac ga                                            22


<210>  100
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  100
agaaaauuga gagaagucca c                                             21

<210>  101
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  101
uaccaauuua ugccuacagu u                                             21


<210>  102
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  102
uaccaauuua ugccuacagc c                                             21


<210>  103
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  103
uaccaauuua ugccuacagc uu                                            22


<210>  104
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  104
uaccaauuua ugccuacagc cu                                            22

<210>  105
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  105
uaccaauuua ugccuacagc cuu                                           23


<210>  106
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  106
uaccaauuua ugccuacagc cuc                                           23

<210>  107
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  107
uaccaauuua ugccuacagu u                                             21


<210>  108
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  108
uauugagaga aguccaccac g                                             21

<210>  109
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  109
uauugagaga aguccaccau u                                             21

<210>  110
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  110
uauugagaga aguccaccac g                                             21

<210>  111
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  111
uauugagaga aguccaccac uu                                            22

<210>  112
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  112
uauugagaga aguccaccac ga                                            22

<210>  113
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  113
uauugagaga aguccaccac g                                             21

<210>  114
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  114
uuugagagaa guccaccacu u                                             21

<210>  115
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  115
uuugagagaa guccaccacg a                                             21

<210>  116
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  116
uuugagagaa guccaccacg uu                                            22

<210>  117
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  117
uuugagagaa guccaccacg ag                                            22


<210>  118
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  118
uuugagagaa guccaccacu u                                             21

<210>  119
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  119
uauugagaga aguccaccac uu                                            22

<210>  120
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  120
uauugagaga aguccaccac uu                                            22

<210>  121
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  121
uauugagaga aguccaccac guu                                           23

<210>  122
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  122
uauugagaga aguccaccac uu                                            22

<210>  123
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  123
uauugagaga aguccaccac gag                                           23

<210>  124
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  124
uauugagaga aguccaccac uu                                            22

<210>  125
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  125
agaaaauuga gagaaguccu u                                             21

<210>  126
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  126
agaaaauuga gagaagucca c                                             21

<210>  127
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  127
agaaaauuga gagaagucca cuu                                           23

<210>  128
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  128
agaaaauuga gagaagucca cc                                            22

<210>  129
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  129
ugaaaauuga gagaaguccu u                                             21

<210>  130
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  130
ugaaaauuga gagaagucca c                                             21

<210>  131
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  131
accaauuuau gccuacagcu u                                             21

<210>  132
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  132
accaauuuau gccuacagcc uu                                            22

<210>  133
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  133
accaauuuau gccuacagcc uc                                            22

<210>  134
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  134
uccaauuuau gccuacagcu u                                             21

<210>  135
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  135
uccaauuuau gccuacagcc uu                                            22

<210>  136
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  136
uaccaauuua ugccuacagc c                                             21

<210>  137
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  137
uaccaauuua ugccuacagc c                                             21

<210>  138
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  138
uaccaauuua ugccuacagc c                                             21

<210>  139
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  139
uaccaauuua ugccuacagc u                                             21

<210>  140
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  140
uaccaauuua ugccuacagc g                                             21

<210>  141
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  141
aaccaauuua ugccuacagc c                                             21

<210>  142
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  142
uaccaauuua ugccuacagu u                                             21

<210>  143
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  143
uaccaauuua ugccuacagc c                                             21

<210>  144
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  144
accaauuuau gccuacagcc u                                             21

<210>  145
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  145
uccaauuuau gccuacagcc u                                             21

<210>  146
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  146
accaauuuau gccuacagcc g                                             21

<210>  147
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  147
uccaauuuau gccuacagcc g                                             21

<210>  148
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence

<400>  148
uaccaauuua ugccuacagg g                                             21


<210>  149
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  149
uaccaauuua ugccuacagg ccuuau                                        26

<210>  150
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  150
uaccaauuua ugccuacagg ccu                                           23

<210>  151
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223> HBV RNAi Agent antisense strand unmodified sequence

<400>  151
uaccaauuua ugccuacagg c                                             21

<210>  152
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  152
ugugaagcga agugcacacu u                                             21

<210>  153
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  153
uaccaauuua ugccuacagc cuccgc                                        26

<210>  154
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  154
uaccaauuua ugccuacagu u                                             21

<210>  155
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  155
auugagagaa guccaccacg a                                             21

<210>  156
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  156
auugagagaa guccaccacu u                                             21

<210>  157
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  157
uuugagagaa guccaccacg a                                             21

<210>  158
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  158
aauugagaga aguccaccac g                                             21

<210>  159
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  159
aauugagaga aguccaccau u                                             21


<210>  160
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  160
uauugagaga aguccaccac g                                             21

<210>  161
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  161
uaccaauuua ugccuacagg u                                             21

<210>  162
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  162
uaccaauuua ugccuacagc c                                             21

<210>  163
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  163
uaccaauuua ugccuacagc cuu                                           23

<210>  164
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  164
uaccaauuua ugccuacagc cuc                                           23

<210>  165
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  165
uuugagagaa guccaccacu u                                             21

<210>  166
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  166
auugagagaa guccaccacg guu                                           23

<210>  167
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  167
auugagagaa guccaccacg agu                                           23

<210>  168
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  168
uauugagaga aguccaccac guu                                           23

<210>  169
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  169
uauugagaga aguccaccac gag                                           23

<210>  170
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  170
uauugagaga aguccaccac ga                                            22

<210>  171
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  171
agaaaauuga gagaagucca c                                             21

<210>  172
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  172
uaccaauuua ugccuacagc uu                                            22

<210>  173
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  173
uaccaauuua ugccuacagc cu                                            22

<210>  174
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  174
uauugagaga aguccaccau u                                             21

<210>  175
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  175
uauugagaga aguccaccac uu                                            22

<210>  176
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  176
uuugagagaa guccaccacg uu                                            22

<210>  177
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  177
uuugagagaa guccaccacg ag                                            22

<210>  178
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  178
agaaaauuga gagaaguccu u                                             21

<210>  179
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  179
agaaaauuga gagaagucca cuu                                           23

<210>  180
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  180
agaaaauuga gagaagucca cc                                            22

<210>  181
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  181
ugaaaauuga gagaagucca c                                             21

<210>  182
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  182
accaauuuau gccuacagcu u                                             21

<210>  183
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  183
accaauuuau gccuacagcc uu                                            22

<210>  184
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  184
accaauuuau gccuacagcc uc                                            22

<210>  185
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  185
uccaauuuau gccuacagcu u                                             21

<210>  186
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  186
uccaauuuau gccuacagcc uu                                            22

<210>  187
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  187
uaccaauuua ugccuacagc u                                             21

<210>  188
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  188
uaccaauuua ugccuacagc g                                             21

<210>  189
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  189
aaccaauuua ugccuacagc c                                             21


<210>  190
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  190
accaauuuau gccuacagcc u                                             21

<210>  191
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  191
uccaauuuau gccuacagcc u                                             21

<210>  192
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  192
accaauuuau gccuacagcc g                                             21

<210>  193
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  193
uccaauuuau gccuacagcc g                                             21
 
<210>  194
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  194
uaccaauuua ugccuacagg g                                             21

<210>  195
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  195
uugccuguag gcauaaauug guaut                                         25

<210>  196
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  196
uauaugccug uaggcauaaa uuggua                                        26

<210>  197
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  197
gcggaggcug uaggcauaaa uuggta                                        26

<210>  198
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  198
cuguaggcau aaauugguau u                                             21

<210>  199
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  199
gccuguaggc auaaauuggu a                                             21

<210>  200
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  200
gccuguaggc auaaauuggu a                                             21

<210>  201
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  201
gccuguaggc auaaauuggu a                                             21

<210>  202
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  202
gccuguaggc auaaauuggt a                                             21

<210>  203
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  203
aacuguaggc auaaauuggu a                                             21

<210>  204
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  204
ucguggugga cuucucucaa u                                             21

<210>  205
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  205
aaguggugga cuucucucaa u                                             21
 
<210>  206
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  206
ucguggugga cuucucucaa t                                             21

<210>  207
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  207
cgugguggac uucucucaau u                                             21

<210>  208
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  208
aaugguggac uucucucaau u                                             21

<210>  209
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  209
cgugguggac uucucucaat t                                             21

<210>  210
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  210
ggacuucucu caauuuucua a                                             21

<210>  211
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  211
cgugguggac uucucucaau a                                             21

<210>  212
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  212
ucguggugga cuucucucaa a                                             21

<210>  213
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  213
accuguaggc auaaauuggu a                                             21

<210>  214
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  214
cuguaggcau aaauuggua                                                19

<210>  215
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  215
cuguaggcau aaauuggua                                                19

<210>  216
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  216
cuguaggcau aaauuggua                                                19

<210>  217
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  217
acuguaggca uaaauuggua                                               20

<210>  218
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  218
ggcuguaggc auaaauuggu a                                             21

<210>  219
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  219
aaguggugga cuucucucaa u                                             21

<210>  220
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  220
aaguggugga cuucucucaa a                                             21

<210>  221
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  221
ccguggugga cuucucucaa u                                             21

<210>  222
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  222
ccguggugga cuucucucaa u                                             21

<210>  223
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  223
cucguggugg acuucucuca au                                            22

<210>  224
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  224
gugguggacu ucucucaau                                                19

<210>  225
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  225
gugguggacu ucucucaauu u                                             21

<210>  226
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  226
ucguggugga cuucucucaa uu                                            22

<210>  227
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  227
ugguggacuu cucucaauu                                                19

<210>  228
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  228
ugguggacuu cucucaauu                                                19

<210>  229
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  229
guggacuucu cucaauuuuc u                                             21

<210>  230
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  230
cuguaggcau aaauugguau u                                             21

<210>  231
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  231
gcuguaggca uaaauuggua uu                                            22

<210>  232
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  232
ggcuguaggc auaaauuggu auu                                           23

<210>  233
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  233
aacuguaggc auaaauuggu auu                                           23

<210>  234
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  234
ugguggacuu cucucaauau u                                             21

<210>  235
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  235
gugguggacu ucucucaaua uu                                            22

<210>  236
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  236
aaugguggac uucucucaau auu                                           23

<210>  237
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  237
cgugguggac uucucucaau auu                                           23

<210>  238
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  238
cgugguggac uucucucaau a                                             21

<210>  239
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  239
aaguggugga cuucucucaa u                                             21

<210>  240
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  240
gugguggacu ucucucaaau u                                             21

<210>  241
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  241
cgugguggac uucucucaaa uu                                            22

<210>  242
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  242
aaguggugga cuucucucaa auu                                           23

<210>  243
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  243
ucguggugga cuucucucaa auu                                           23

<210>  244
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  244
gugguggacu ucucucaaua uu                                            22

<210>  245
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  245
cgugguggac uucucucaau auu                                           23

<210>  246
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  246
cucguggugg acuucucuca aua                                           23

<210>  247
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  247
cucguggugg acuucucuca auauu                                         25

<210>  248
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  248
ggcuguaggc auaaauuggu a                                             21

<210>  249
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  249
gaggcuguag gcauaaauug gua                                           23

<210>  250
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  250
gaggcuguag gcauaaauug guauu                                         25

<210>  251
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  251
ggacuucucu caauuuucu                                                19

<210>  252
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  252
guggacuucu cucaauuuuc u                                             21

<210>  253
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  253
gguggacuuc ucucaauuuu cu                                            22

<210>  254
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  254
ggacuucucu caauuuuca                                                19

<210>  255
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  255
ggacuucucu caauuuuca                                                19

<210>  256
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  256
gcuguaggca uaaauuggu                                                19

<210>  257
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  257
ggcuguaggc auaaauuggu                                               20

<210>  258
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  258
gaggcuguag gcauaaauug gu                                            22

<210>  259
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  259
gcuguaggca uaaauugga                                                19

<210>  260
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  260
ggcuguaggc auaaauugga                                               20

<210>  261
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  261
agcuguaggc auaaauuggu a                                             21

<210>  262
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  262
cgcuguaggc auaaauuggu a                                             21

<210>  263
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  263
ggcuguaggc auaaauuggu u                                             21

<210>  264
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  264
cuguaggcau aaauugguau u                                             21
 
<210>  265
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  265
cuguaggcau aaauugguau u                                             21

<210>  266
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  266
aggcuguagg cauaaauugg u                                             21

<210>  267
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  267
aggcuguagg cauaaauugg a                                             21

<210>  268
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  268
cggcuguagg cauaaauugg u                                             21

<210>  269
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  269
cggcuguagg cauaaauugg a                                             21

<210>  270
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  270
cccuguaggc auaaauuggu a                                             21

<210>  271
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  271
cgcuguaggc auaaauuggu a                                             21

<210>  272
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  272
cccuguaggc auaaauuggu a                                             21

<210>  273
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  273
guggacuucu cucaauuuuc u                                             21

<210>  274
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand modified sequence

<400>  274
cgcuguaggc auaaauuggu a                                             21

<210>  275
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  275
uugccuguag gcauaaauug guaut                                         25

<210>  276
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  276
uauaugccug uaggcauaaa uuggua                                        26

<210>  277
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  277
gcggaggcug uaggcauaaa uuggta                                        26

<210>  278
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  278
cuguaggcau aaauugguau u                                             21

<210>  279
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  279
gccuguaggc auaaauuggu a                                             21

<210>  280
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  280
gccuguaggc auaaauuggt a                                             21

<210>  281
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  281
aacuguaggc auaaauuggu a                                             21

<210>  282
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  282 
ucguggugga cuucucucaa u                                             21

<210>  283
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  283
aaguggugga cuucucucaa u                                             21

<210>  284
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  284
ucguggugga cuucucucaa t                                             21

<210>  285
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  285
cgugguggac uucucucaau u                                             21

<210>  286
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  286
aaugguggac uucucucaau u                                             21

<210>  287
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  287
cgugguggac uucucucaat t                                             21

<210>  288
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  288
ggacuucucu caauuuucua a                                             21

<210>  289
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  289
cgugguggac uucucucaau a                                             21

<210>  290
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  290
ucguggugga cuucucucaa a                                             21

<210>  291
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  291
accuguaggc auaaauuggu a                                             21

<210>  292
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  292
cuguaggcau aaauuggua                                                19

<210>  293
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  293
acuguaggca uaaauuggua                                               20

<210>  294
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  294
ggcuguaggc auaaauuggu a                                             21

<210>  295
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  295
aaguggugga cuucucucaa a                                             21
 
<210>  296
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  296
ccguggugga cuucucucaa u                                             21

<210>  297
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  297
cucguggugg acuucucuca au                                            22

<210>  298
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  298
gugguggacu ucucucaau                                                19

<210>  299
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  299
gugguggacu ucucucaauu u                                             21

<210>  300
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  300
ucguggugga cuucucucaa uu                                            22

<210>  301
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  301
ugguggacuu cucucaauu                                                19

<210>  302
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  302
guggacuucu cucaauuuuc u                                             21

<210>  303
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  303
gcuguaggca uaaauuggua uu                                            22

<210>  304
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  304
ggcuguaggc auaaauuggu auu                                           23

<210>  305
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  305
aacuguaggc auaaauuggu auu                                           23

<210>  306
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  306
ugguggacuu cucucaauau u                                             21

<210>  307
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  307
gugguggacu ucucucaaua uu                                            22

<210>  308
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  308
aaugguggac uucucucaau auu                                           23

<210>  309
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  309
cgugguggac uucucucaau auu                                           23

<210>  310
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  310
gugguggacu ucucucaaau u                                             21

<210>  311
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  311
cgugguggac uucucucaaa uu                                            22

<210>  312
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  312
aaguggugga cuucucucaa auu                                           23

<210>  313
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  313
ucguggugga cuucucucaa auu                                           23

<210>  314
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  314
cucguggugg acuucucuca aua                                           23

<210>  315
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  315
cucguggugg acuucucuca auauu                                         25

<210>  316
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  316
gaggcuguag gcauaaauug gua                                           23

<210>  317
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  317
gaggcuguag gcauaaauug guauu                                         25

<210>  318
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  318
ggacuucucu caauuuucu                                                19

<210>  319
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  319
gguggacuuc ucucaauuuu cu                                            22

<210>  320
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  320
ggacuucucu caauuuuca                                                19

<210>  321
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  321
guggacuucu cucaauuuuc a                                             21

<210>  322
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  322
gcuguaggca uaaauuggu                                                19

<210>  323
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  323
ggcuguaggc auaaauuggu                                               20

<210>  324
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  324
gaggcuguag gcauaaauug gu                                            22

<210>  325
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  325
gcuguaggca uaaauugga                                                19

<210>  326
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  326
ggcuguaggc auaaauugga                                               20

<210>  327
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  327
agcuguaggc auaaauuggu a                                             21

<210>  328
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  328
cgcuguaggc auaaauuggu a                                             21

<210>  329
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  329
ggcuguaggc auaaauuggu u                                             21

<210>  330
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  330
aggcuguagg cauaaauugg u                                             21

<210>  331
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  331
aggcuguagg cauaaauugg a                                             21

<210>  332
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  332
cggcuguagg cauaaauugg u                                             21

<210>  333
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  333
cggcuguagg cauaaauugg a                                             21

<210>  334
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  334
cccuguaggc auaaauuggu a                                             21
 
