                         SEQUENCE LISTING

<110>  Decibel Therapeutics, Inc.
       Regeneron Pharmaceuticals, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING SENSORINEURAL HEARING LOSS 
       USING OTOFERLIN DUAL VECTOR SYSTEMS

<130>  51471-003WO4

<150>  62/965,770
<151>  2020-01-24

<150>  62/928,279
<151>  2019-10-30

<150>  62/802,890
<151>  2019-02-08

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  1997
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Leu Ile His Leu Lys Thr Val Ser Glu Leu Arg Gly Arg 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Asp Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Met Leu Glu Ile 
    50                  55                  60                  


Gln Val Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Arg Met Val Leu Gln Lys Val Val Glu Glu Ser His Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Ile Asp Asp Asn Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Cys Val Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Ser Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Glu Lys 
    130                 135                 140                 


Asp Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Ser 
145                 150                 155                 160 


Arg Pro Pro Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe 
                165                 170                 175     


Ser Ala Met Lys Leu Gly Lys Asn Arg Ser His Lys Glu Glu Pro Gln 
            180                 185                 190         


Arg Pro Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu 
        195                 200                 205             


Ala Ile Arg Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala 
    210                 215                 220                 


Ser Val Thr Ala Leu Thr Thr Asn Val Ser Asn Lys Arg Ser Lys Pro 
225                 230                 235                 240 


Asp Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val 
                245                 250                 255     


Ser Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp 
            260                 265                 270         


Pro Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met 
        275                 280                 285             


Lys Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp 
    290                 295                 300                 


Phe His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser 
305                 310                 315                 320 


Val Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser 
                325                 330                 335     


Phe Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe 
            340                 345                 350         


His His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ser Gly 
        355                 360                 365             


Leu Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp 
    370                 375                 380                 


Asn Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile 
385                 390                 395                 400 


Glu Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp 
                405                 410                 415     


Ala Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met 
            420                 425                 430         


Asn Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn 
        435                 440                 445             


Lys Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys 
    450                 455                 460                 


Gly Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu 
465                 470                 475                 480 


Gln Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys 
                485                 490                 495     


Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr 
            500                 505                 510         


His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe 
        515                 520                 525             


Leu Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg 
    530                 535                 540                 


Asn Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly 
545                 550                 555                 560 


Glu Gly Val Ser Phe Arg Ala Arg Leu Leu Leu Gly Leu Ala Val Glu 
                565                 570                 575     


Ile Val Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln 
            580                 585                 590         


Val Glu Gln Ala Thr Pro Ile Ser Glu Ser Cys Ala Gly Lys Met Glu 
        595                 600                 605             


Glu Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg 
    610                 615                 620                 


Arg Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr 
625                 630                 635                 640 


Gly Asn Glu Val Asp Gly Leu Ser Arg Pro Gln Arg Pro Arg Pro Arg 
                645                 650                 655     


Lys Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ala Ser 
            660                 665                 670         


Asp Asp Glu Ala Gly Asp Ala Gly Asp Leu Ala Ser Val Ser Ser Thr 
        675                 680                 685             


Pro Pro Met Arg Pro Gln Val Thr Asp Arg Asn Tyr Phe His Leu Pro 
    690                 695                 700                 


Tyr Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp 
705                 710                 715                 720 


Gln Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp 
                725                 730                 735     


Lys Leu Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu 
            740                 745                 750         


Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser 
        755                 760                 765             


Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His 
    770                 775                 780                 


Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg 
785                 790                 795                 800 


Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val 
                805                 810                 815     


Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu 
            820                 825                 830         


Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp 
        835                 840                 845             


Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg 
    850                 855                 860                 


Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly 
865                 870                 875                 880 


Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys 
                885                 890                 895     


Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu 
            900                 905                 910         


Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly 
        915                 920                 925             


Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu 
    930                 935                 940                 


His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe 
945                 950                 955                 960 


Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp 
                965                 970                 975     


Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln 
            980                 985                 990         


Ser Gln Cys Thr Glu Val Leu Asn  Glu Thr Leu Cys Pro  Thr Trp Asp 
        995                 1000                 1005             


Gln Met  Leu Val Phe Asp Asn  Leu Glu Leu Tyr Gly  Glu Ala His 
    1010                 1015                 1020             


Glu Leu  Arg Asp Asp Pro Pro  Ile Ile Val Ile Glu  Ile Tyr Asp 
    1025                 1030                 1035             


Gln Asp  Ser Met Gly Lys Ala  Asp Phe Met Gly Arg  Thr Phe Ala 
    1040                 1045                 1050             


Lys Pro  Leu Val Lys Met Ala  Asp Glu Ala Tyr Cys  Pro Pro Arg 
    1055                 1060                 1065             


Phe Pro  Pro Gln Leu Glu Tyr  Tyr Gln Ile Tyr Arg  Gly Asn Ala 
    1070                 1075                 1080             


Thr Ala  Gly Asp Leu Leu Ala  Ala Phe Glu Leu Leu  Gln Ile Gly 
    1085                 1090                 1095             


Pro Ala  Gly Lys Ala Asp Leu  Pro Pro Ile Asn Gly  Pro Val Asp 
    1100                 1105                 1110             


Val Asp  Arg Gly Pro Ile Met  Pro Val Pro Met Gly  Ile Arg Pro 
    1115                 1120                 1125             


Val Leu  Ser Lys Tyr Arg Val  Glu Val Leu Phe Trp  Gly Leu Arg 
    1130                 1135                 1140             


Asp Leu  Lys Arg Val Asn Leu  Ala Gln Val Asp Arg  Pro Arg Val 
    1145                 1150                 1155             


Asp Ile  Glu Cys Ala Gly Lys  Gly Val Gln Ser Ser  Leu Ile His 
    1160                 1165                 1170             


Asn Tyr  Lys Lys Asn Pro Asn  Phe Asn Thr Leu Val  Lys Trp Phe 
    1175                 1180                 1185             


Glu Val  Asp Leu Pro Glu Asn  Glu Leu Leu His Pro  Pro Leu Asn 
    1190                 1195                 1200             


Ile Arg  Val Val Asp Cys Arg  Ala Phe Gly Arg Tyr  Thr Leu Val 
    1205                 1210                 1215             


Gly Ser  His Ala Val Ser Ser  Leu Arg Arg Phe Ile  Tyr Arg Pro 
    1220                 1225                 1230             


Pro Asp  Arg Ser Ala Pro Ser  Trp Asn Thr Thr Val  Arg Leu Leu 
    1235                 1240                 1245             


Arg Arg  Cys Arg Val Leu Cys  Asn Gly Gly Ser Ser  Ser His Ser 
    1250                 1255                 1260             


Thr Gly  Glu Val Val Val Thr  Met Glu Pro Glu Val  Pro Ile Lys 
    1265                 1270                 1275             


Lys Leu  Glu Thr Met Val Lys  Leu Asp Ala Thr Ser  Glu Ala Val 
    1280                 1285                 1290             


Val Lys  Val Asp Val Ala Glu  Glu Glu Lys Glu Lys  Lys Lys Lys 
    1295                 1300                 1305             


Lys Lys  Gly Thr Ala Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu 
    1310                 1315                 1320             


Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr 
    1325                 1330                 1335             


Met Lys  Glu Gln Leu Arg Gln  Gln Glu Pro Ser Gly  Ile Asp Leu 
    1340                 1345                 1350             


Glu Glu  Lys Glu Glu Val Asp  Asn Thr Glu Gly Leu  Lys Gly Ser 
    1355                 1360                 1365             


Met Lys  Gly Lys Glu Lys Ala  Arg Ala Ala Lys Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Lys  Thr Gln Ser Ser Gly  Ser Gly Gln Gly Ser  Glu Ala Pro 
    1385                 1390                 1395             


Glu Lys  Lys Lys Pro Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys 
    1400                 1405                 1410             


Glu Leu  Glu Ser Glu Phe Asp  Asn Phe Glu Asp Trp  Leu His Thr 
    1415                 1420                 1425             


Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser 
    1430                 1435                 1440             


Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys 
    1445                 1450                 1455             


Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly 
    1460                 1465                 1470             


Tyr Asp  Ser Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp 
    1475                 1480                 1485             


Pro Ile  Asn Val Leu Val Arg  Val Tyr Val Val Arg  Ala Thr Asp 
    1490                 1495                 1500             


Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala 
    1505                 1510                 1515             


Ile Arg  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile 
    1520                 1525                 1530             


Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu 
    1535                 1540                 1545             


Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp 
    1550                 1555                 1560             


Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile 
    1565                 1570                 1575             


Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly 
    1580                 1585                 1590             


Ile Ala  Gln Thr Tyr Ser Thr  His Gly Tyr Asn Ile  Trp Arg Asp 
    1595                 1600                 1605             


Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys Asp Gly 
    1610                 1615                 1620             


Lys Val  Asp Gly Pro His Phe  Gly Pro Pro Gly Arg  Val Lys Val 
    1625                 1630                 1635             


Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn 
    1640                 1645                 1650             


Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Leu Ala Leu 
    1655                 1660                 1665             


Arg His  Trp Glu Asp Ile Pro  Arg Ala Gly Cys Arg  Leu Val Pro 
    1670                 1675                 1680             


Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
    1685                 1690                 1695             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1700                 1705                 1710             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1715                 1720                 1725             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1730                 1735                 1740             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1745                 1750                 1755             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1760                 1765                 1770             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1775                 1780                 1785             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1790                 1795                 1800             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1805                 1810                 1815             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1820                 1825                 1830             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1835                 1840                 1845             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1850                 1855                 1860             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1865                 1870                 1875             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1880                 1885                 1890             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1895                 1900                 1905             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1910                 1915                 1920             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1925                 1930                 1935             


Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1940                 1945                 1950             


Ala Arg  Tyr Phe Leu Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys 
    1955                 1960                 1965             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Leu Leu Ala  Leu Phe Leu 
    1970                 1975                 1980             


Tyr Ser  Val Pro Gly Tyr Leu  Val Lys Lys Ile Leu  Gly Ala 
    1985                 1990                 1995         


<210>  2
<211>  1230
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ile Lys Thr Glu Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val 
1               5                   10                  15      


Leu Glu Glu Leu Ser Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp 
            20                  25                  30          


Lys Asp Gln Gly His Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu 
        35                  40                  45              


Lys Ser Cys Met Arg Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met 
    50                  55                  60                  


Leu Arg Ala Gln Val Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu 
65                  70                  75                  80  


Cys Gln Asn Phe Leu Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln 
                85                  90                  95      


His Ser Ile Pro Asp Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg 
            100                 105                 110         


Val Ala Tyr Ala Arg Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val 
        115                 120                 125             


Glu Glu Glu Thr Gly Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu 
    130                 135                 140                 


Lys Leu Pro Gly Lys Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln 
145                 150                 155                 160 


Ala Lys Val Glu Leu Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys 
                165                 170                 175     


Glu Phe Leu Cys Gly Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala 
            180                 185                 190         


Gln Gly Leu Gly Leu His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr 
        195                 200                 205             


Lys Lys Gln Ala Phe Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser 
    210                 215                 220                 


Leu Phe Ala Ala Asp Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val 
225                 230                 235                 240 


Phe Phe Ile Asn Gln Ser Gln Cys Thr Glu Val Leu Asn Glu Thr Leu 
                245                 250                 255     


Cys Pro Thr Trp Asp Gln Met Leu Val Phe Asp Asn Leu Glu Leu Tyr 
            260                 265                 270         


Gly Glu Ala His Glu Leu Arg Asp Asp Pro Pro Ile Ile Val Ile Glu 
        275                 280                 285             


Ile Tyr Asp Gln Asp Ser Met Gly Lys Ala Asp Phe Met Gly Arg Thr 
    290                 295                 300                 


Phe Ala Lys Pro Leu Val Lys Met Ala Asp Glu Ala Tyr Cys Pro Pro 
305                 310                 315                 320 


Arg Phe Pro Pro Gln Leu Glu Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala 
                325                 330                 335     


Thr Ala Gly Asp Leu Leu Ala Ala Phe Glu Leu Leu Gln Ile Gly Pro 
            340                 345                 350         


Ala Gly Lys Ala Asp Leu Pro Pro Ile Asn Gly Pro Val Asp Val Asp 
        355                 360                 365             


Arg Gly Pro Ile Met Pro Val Pro Met Gly Ile Arg Pro Val Leu Ser 
    370                 375                 380                 


Lys Tyr Arg Val Glu Val Leu Phe Trp Gly Leu Arg Asp Leu Lys Arg 
385                 390                 395                 400 


Val Asn Leu Ala Gln Val Asp Arg Pro Arg Val Asp Ile Glu Cys Ala 
                405                 410                 415     


Gly Lys Gly Val Gln Ser Ser Leu Ile His Asn Tyr Lys Lys Asn Pro 
            420                 425                 430         


Asn Phe Asn Thr Leu Val Lys Trp Phe Glu Val Asp Leu Pro Glu Asn 
        435                 440                 445             


Glu Leu Leu His Pro Pro Leu Asn Ile Arg Val Val Asp Cys Arg Ala 
    450                 455                 460                 


Phe Gly Arg Tyr Thr Leu Val Gly Ser His Ala Val Ser Ser Leu Arg 
465                 470                 475                 480 


Arg Phe Ile Tyr Arg Pro Pro Asp Arg Ser Ala Pro Ser Trp Asn Thr 
                485                 490                 495     


Thr Gly Glu Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys 
            500                 505                 510         


Leu Glu Thr Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys 
        515                 520                 525             


Val Asp Val Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly 
    530                 535                 540                 


Thr Ala Glu Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp 
545                 550                 555                 560 


Trp Trp Ser Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu 
                565                 570                 575     


Arg Gln Gln Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val 
            580                 585                 590         


Asp Asn Thr Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala 
        595                 600                 605             


Arg Ala Ala Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser 
    610                 615                 620                 


Gly Gln Gly Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu 
625                 630                 635                 640 


Leu Lys Val Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu 
                645                 650                 655     


Asp Trp Leu His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp 
            660                 665                 670         


Glu Asp Gly Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly 
        675                 680                 685             


Ser Leu Cys Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu 
    690                 695                 700                 


Ala Gly Tyr Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn 
705                 710                 715                 720 


Asp Pro Ile Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp 
                725                 730                 735     


Leu His Pro Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile 
            740                 745                 750         


Arg Leu Gly Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys 
        755                 760                 765             


Gln Leu Asn Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe 
    770                 775                 780                 


Pro Met Glu Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val 
785                 790                 795                 800 


Gly Thr Asp Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg 
                805                 810                 815     


Phe Tyr Ser Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser 
            820                 825                 830         


Thr His Gly Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile 
        835                 840                 845             


Leu Thr Arg Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly 
    850                 855                 860                 


Pro Pro Gly Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser 
865                 870                 875                 880 


Glu Ile Glu Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val 
                885                 890                 895     


Ala Leu Leu Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys 
            900                 905                 910         


Arg Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Leu Asn Pro Asp 
        915                 920                 925             


Lys Pro Gly Ile Glu Gln Gly Arg Leu Glu Leu Trp Val Asp Met Phe 
    930                 935                 940                 


Pro Met Asp Met Pro Ala Pro Gly Thr Pro Leu Asp Ile Ser Pro Arg 
945                 950                 955                 960 


Lys Pro Lys Lys Tyr Glu Leu Arg Val Ile Ile Trp Asn Thr Asp Glu 
                965                 970                 975     


Val Val Leu Glu Asp Asp Asp Phe Phe Thr Gly Glu Lys Ser Ser Asp 
            980                 985                 990         


Ile Phe Val Arg Gly Trp Leu Lys  Gly Gln Gln Glu Asp  Lys Gln Asp 
        995                 1000                 1005             


Thr Asp  Val His Tyr His Ser  Leu Thr Gly Glu Gly  Asn Phe Asn 
    1010                 1015                 1020             


Trp Arg  Tyr Leu Phe Pro Phe  Asp Tyr Leu Ala Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ile Val  Ile Ser Lys Lys Glu  Ser Met Phe Ser Trp  Asp Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Lys Ile Pro Ala Arg  Leu Thr Leu Gln Ile  Trp Asp Ala 
    1055                 1060                 1065             


Asp His  Phe Ser Ala Asp Asp  Phe Leu Gly Ala Ile  Glu Leu Asp 
    1070                 1075                 1080             


Leu Asn  Arg Phe Pro Arg Gly  Ala Lys Thr Ala Lys  Gln Cys Thr 
    1085                 1090                 1095             


Met Glu  Met Ala Thr Gly Glu  Val Asp Val Pro Leu  Val Ser Ile 
    1100                 1105                 1110             


Phe Lys  Gln Lys Arg Val Lys  Gly Trp Trp Pro Leu  Leu Ala Arg 
    1115                 1120                 1125             


Asn Glu  Asn Asp Glu Phe Glu  Leu Thr Gly Lys Val  Glu Ala Glu 
    1130                 1135                 1140             


Leu His  Leu Leu Thr Ala Glu  Glu Ala Glu Lys Asn  Pro Val Gly 
    1145                 1150                 1155             


Leu Ala  Arg Asn Glu Pro Asp  Pro Leu Glu Lys Pro  Asn Arg Pro 
    1160                 1165                 1170             


Asp Thr  Ser Phe Ile Trp Phe  Leu Asn Pro Leu Lys  Ser Ala Arg 
    1175                 1180                 1185             


Tyr Phe  Leu Trp His Thr Tyr  Arg Trp Leu Leu Leu  Lys Leu Leu 
    1190                 1195                 1200             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Ala Leu Phe  Leu Tyr Ser 
    1205                 1210                 1215             


Val Pro  Gly Tyr Leu Val Lys  Lys Ile Leu Gly Ala  
    1220                 1225                 1230 


<210>  3
<211>  1230
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ile Lys Thr Glu Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val 
1               5                   10                  15      


Leu Glu Glu Leu Ser Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp 
            20                  25                  30          


Lys Asp Gln Gly His Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu 
        35                  40                  45              


Lys Ser Cys Met Arg Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met 
    50                  55                  60                  


Leu Arg Ala Gln Val Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu 
65                  70                  75                  80  


Cys Gln Asn Phe Leu Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln 
                85                  90                  95      


His Ser Ile Pro Asp Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg 
            100                 105                 110         


Val Ala Tyr Ala Arg Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val 
        115                 120                 125             


Glu Glu Glu Thr Gly Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu 
    130                 135                 140                 


Lys Leu Pro Gly Lys Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln 
145                 150                 155                 160 


Ala Lys Val Glu Leu Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys 
                165                 170                 175     


Glu Phe Leu Cys Gly Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala 
            180                 185                 190         


Gln Gly Leu Gly Leu His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr 
        195                 200                 205             


Lys Lys Gln Ala Phe Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser 
    210                 215                 220                 


Leu Phe Ala Ala Asp Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val 
225                 230                 235                 240 


Phe Phe Ile Asn Gln Ser Gln Cys Thr Glu Val Leu Asn Glu Thr Leu 
                245                 250                 255     


Cys Pro Thr Trp Asp Gln Met Leu Val Phe Asp Asn Leu Glu Leu Tyr 
            260                 265                 270         


Gly Glu Ala His Glu Leu Arg Asp Asp Pro Pro Ile Ile Val Ile Glu 
        275                 280                 285             


Ile Tyr Asp Gln Asp Ser Met Gly Lys Ala Asp Phe Met Gly Arg Thr 
    290                 295                 300                 


Phe Ala Lys Pro Leu Val Lys Met Ala Asp Glu Ala Tyr Cys Pro Pro 
305                 310                 315                 320 


Arg Phe Pro Pro Gln Leu Glu Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala 
                325                 330                 335     


Thr Ala Gly Asp Leu Leu Ala Ala Phe Glu Leu Leu Gln Ile Gly Pro 
            340                 345                 350         


Ala Gly Lys Ala Asp Leu Pro Pro Ile Asn Gly Pro Val Asp Val Asp 
        355                 360                 365             


Arg Gly Pro Ile Met Pro Val Pro Met Gly Ile Arg Pro Val Leu Ser 
    370                 375                 380                 


Lys Tyr Arg Val Glu Val Leu Phe Trp Gly Leu Arg Asp Leu Lys Arg 
385                 390                 395                 400 


Val Asn Leu Ala Gln Val Asp Arg Pro Arg Val Asp Ile Glu Cys Ala 
                405                 410                 415     


Gly Lys Gly Val Gln Ser Ser Leu Ile His Asn Tyr Lys Lys Asn Pro 
            420                 425                 430         


Asn Phe Asn Thr Leu Val Lys Trp Phe Glu Val Asp Leu Pro Glu Asn 
        435                 440                 445             


Glu Leu Leu His Pro Pro Leu Asn Ile Arg Val Val Asp Cys Arg Ala 
    450                 455                 460                 


Phe Gly Arg Tyr Thr Leu Val Gly Ser His Ala Val Ser Ser Leu Arg 
465                 470                 475                 480 


Arg Phe Ile Tyr Arg Pro Pro Asp Arg Ser Ala Pro Ser Trp Asn Thr 
                485                 490                 495     


Thr Gly Glu Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys 
            500                 505                 510         


Leu Glu Thr Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys 
        515                 520                 525             


Val Asp Val Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly 
    530                 535                 540                 


Thr Ala Glu Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp 
545                 550                 555                 560 


Trp Trp Ser Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu 
                565                 570                 575     


Arg Gln Gln Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val 
            580                 585                 590         


Asp Asn Thr Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala 
        595                 600                 605             


Arg Ala Ala Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser 
    610                 615                 620                 


Gly Gln Gly Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu 
625                 630                 635                 640 


Leu Lys Val Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu 
                645                 650                 655     


Asp Trp Leu His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp 
            660                 665                 670         


Glu Asp Gly Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly 
        675                 680                 685             


Ser Leu Cys Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu 
    690                 695                 700                 


Ala Gly Tyr Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn 
705                 710                 715                 720 


Asp Pro Ile Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp 
                725                 730                 735     


Leu His Pro Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile 
            740                 745                 750         


Arg Leu Gly Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys 
        755                 760                 765             


Gln Leu Asn Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe 
    770                 775                 780                 


Pro Met Glu Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val 
785                 790                 795                 800 


Gly Thr Asp Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg 
                805                 810                 815     


Phe Tyr Ser Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser 
            820                 825                 830         


Thr His Gly Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile 
        835                 840                 845             


Leu Thr Arg Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly 
    850                 855                 860                 


Pro Pro Gly Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser 
865                 870                 875                 880 


Glu Ile Glu Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val 
                885                 890                 895     


Ala Leu Leu Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys 
            900                 905                 910         


Arg Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Leu Asn Pro Asp 
        915                 920                 925             


Lys Pro Gly Ile Glu Gln Gly Arg Leu Glu Leu Trp Val Asp Met Phe 
    930                 935                 940                 


Pro Met Asp Met Pro Ala Pro Gly Thr Pro Leu Asp Ile Ser Pro Arg 
945                 950                 955                 960 


Lys Pro Lys Lys Tyr Glu Leu Arg Val Ile Ile Trp Asn Thr Asp Glu 
                965                 970                 975     


Val Val Leu Glu Asp Asp Asp Phe Phe Thr Gly Glu Lys Ser Ser Asp 
            980                 985                 990         


Ile Phe Val Arg Gly Trp Leu Lys  Gly Gln Gln Glu Asp  Lys Gln Asp 
        995                 1000                 1005             


Thr Asp  Val His Tyr His Ser  Leu Thr Gly Glu Gly  Asn Phe Asn 
    1010                 1015                 1020             


Trp Arg  Tyr Leu Phe Pro Phe  Asp Tyr Leu Ala Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ile Val  Ile Ser Lys Lys Glu  Ser Met Phe Ser Trp  Asp Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Lys Ile Pro Ala Arg  Leu Thr Leu Gln Ile  Trp Asp Ala 
    1055                 1060                 1065             


Asp His  Phe Ser Ala Asp Asp  Phe Leu Gly Ala Ile  Glu Leu Asp 
    1070                 1075                 1080             


Leu Asn  Arg Phe Pro Arg Gly  Ala Lys Thr Ala Lys  Gln Cys Thr 
    1085                 1090                 1095             


Met Glu  Met Ala Thr Gly Glu  Val Asp Val Pro Leu  Val Ser Ile 
    1100                 1105                 1110             


Phe Lys  Gln Lys Arg Val Lys  Gly Trp Trp Pro Leu  Leu Ala Arg 
    1115                 1120                 1125             


Asn Glu  Asn Asp Glu Phe Glu  Leu Thr Gly Lys Val  Glu Ala Glu 
    1130                 1135                 1140             


Leu His  Leu Leu Thr Ala Glu  Glu Ala Glu Lys Asn  Pro Val Gly 
    1145                 1150                 1155             


Leu Ala  Arg Asn Glu Pro Asp  Pro Leu Glu Lys Pro  Asn Arg Pro 
    1160                 1165                 1170             


Asp Thr  Ala Phe Val Trp Phe  Leu Asn Pro Leu Lys  Ser Ile Lys 
    1175                 1180                 1185             


Tyr Leu  Ile Cys Thr Arg Tyr  Lys Trp Leu Ile Ile  Lys Ile Val 
    1190                 1195                 1200             


Leu Ala  Leu Leu Gly Leu Leu  Met Leu Gly Leu Phe  Leu Tyr Ser 
    1205                 1210                 1215             


Leu Pro  Gly Tyr Met Val Lys  Lys Leu Leu Gly Ala  
    1220                 1225                 1230 


<210>  4
<211>  1307
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Met Thr Asp Thr Gln Asp Gly Pro Ser Glu Ser Ser Gln Ile Met 
1               5                   10                  15      


Arg Ser Leu Thr Pro Leu Ile Asn Arg Glu Glu Ala Phe Gly Glu Ala 
            20                  25                  30          


Gly Glu Ala Gly Leu Trp Pro Ser Ile Thr His Thr Pro Asp Ser Gln 
        35                  40                  45              


Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu Lys Ser 
    50                  55                  60                  


Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys Gly 
65                  70                  75                  80  


Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His Ser Ser 
                85                  90                  95      


Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu Leu 
            100                 105                 110         


Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val Lys Arg 
        115                 120                 125             


His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu Gln Lys 
    130                 135                 140                 


Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Ile Phe 
145                 150                 155                 160 


Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg Val Pro 
                165                 170                 175     


Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly Lys Asp 
            180                 185                 190         


Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg Gly 
        195                 200                 205             


Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu Tyr Leu 
    210                 215                 220                 


Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly Leu Pro 
225                 230                 235                 240 


Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His Ala 
                245                 250                 255     


Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln Leu 
            260                 265                 270         


Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser Ser 
        275                 280                 285             


Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln Ser Gln 
    290                 295                 300                 


Cys Thr Glu Val Leu Asn Glu Thr Leu Cys Pro Thr Trp Asp Gln Met 
305                 310                 315                 320 


Leu Val Phe Asp Asn Leu Glu Leu Tyr Gly Glu Ala His Glu Leu Arg 
                325                 330                 335     


Asp Asp Pro Pro Ile Ile Val Ile Glu Ile Tyr Asp Gln Asp Ser Met 
            340                 345                 350         


Gly Lys Ala Asp Phe Met Gly Arg Thr Phe Ala Lys Pro Leu Val Lys 
        355                 360                 365             


Met Ala Asp Glu Ala Tyr Cys Pro Pro Arg Phe Pro Pro Gln Leu Glu 
    370                 375                 380                 


Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala Thr Ala Gly Asp Leu Leu Ala 
385                 390                 395                 400 


Ala Phe Glu Leu Leu Gln Ile Gly Pro Ala Gly Lys Ala Asp Leu Pro 
                405                 410                 415     


Pro Ile Asn Gly Pro Val Asp Val Asp Arg Gly Pro Ile Met Pro Val 
            420                 425                 430         


Pro Met Gly Ile Arg Pro Val Leu Ser Lys Tyr Arg Val Glu Val Leu 
        435                 440                 445             


Phe Trp Gly Leu Arg Asp Leu Lys Arg Val Asn Leu Ala Gln Val Asp 
    450                 455                 460                 


Arg Pro Arg Val Asp Ile Glu Cys Ala Gly Lys Gly Val Gln Ser Ser 
465                 470                 475                 480 


Leu Ile His Asn Tyr Lys Lys Asn Pro Asn Phe Asn Thr Leu Val Lys 
                485                 490                 495     


Trp Phe Glu Val Asp Leu Pro Glu Asn Glu Leu Leu His Pro Pro Leu 
            500                 505                 510         


Asn Ile Arg Val Val Asp Cys Arg Ala Phe Gly Arg Tyr Thr Leu Val 
        515                 520                 525             


Gly Ser His Ala Val Ser Ser Leu Arg Arg Phe Ile Tyr Arg Pro Pro 
    530                 535                 540                 


Asp Arg Ser Ala Pro Ser Trp Asn Thr Thr Val Arg Leu Leu Arg Arg 
545                 550                 555                 560 


Cys Arg Val Leu Cys Asn Gly Gly Ser Ser Ser His Ser Thr Gly Glu 
                565                 570                 575     


Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys Leu Glu Thr 
            580                 585                 590         


Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys Val Asp Val 
        595                 600                 605             


Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly Thr Ala Glu 
    610                 615                 620                 


Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp Trp Trp Ser 
625                 630                 635                 640 


Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu Arg Gln Gln 
                645                 650                 655     


Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val Asp Asn Thr 
            660                 665                 670         


Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala Arg Ala Ala 
        675                 680                 685             


Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser Gly Gln Gly 
    690                 695                 700                 


Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu Leu Lys Val 
705                 710                 715                 720 


Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu Asp Trp Leu 
                725                 730                 735     


His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp Glu Asp Gly 
            740                 745                 750         


Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly Ser Leu Cys 
        755                 760                 765             


Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu Ala Gly Tyr 
    770                 775                 780                 


Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn Asp Pro Ile 
785                 790                 795                 800 


Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp Leu His Pro 
                805                 810                 815     


Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile Arg Leu Gly 
            820                 825                 830         


Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys Gln Leu Asn 
        835                 840                 845             


Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe Pro Met Glu 
    850                 855                 860                 


Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val Gly Thr Asp 
865                 870                 875                 880 


Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg Phe Tyr Ser 
                885                 890                 895     


Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser Thr His Gly 
            900                 905                 910         


Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile Leu Thr Arg 
        915                 920                 925             


Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly Pro Pro Gly 
    930                 935                 940                 


Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser Glu Ile Glu 
945                 950                 955                 960 


Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val Ala Leu Leu 
                965                 970                 975     


Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys Arg Leu Val 
            980                 985                 990         


Pro Glu His Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
        995                 1000                 1005             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1010                 1015                 1020             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1025                 1030                 1035             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1040                 1045                 1050             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1055                 1060                 1065             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1070                 1075                 1080             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1085                 1090                 1095             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1100                 1105                 1110             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1115                 1120                 1125             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1130                 1135                 1140             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1145                 1150                 1155             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1160                 1165                 1170             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1175                 1180                 1185             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1190                 1195                 1200             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1205                 1210                 1215             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1220                 1225                 1230             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1235                 1240                 1245             


Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1250                 1255                 1260             


Ala Arg  Tyr Phe Leu Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys 
    1265                 1270                 1275             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Leu Leu Ala  Leu Phe Leu 
    1280                 1285                 1290             


Tyr Ser  Val Pro Gly Tyr Leu  Val Lys Lys Ile Leu  Gly Ala 
    1295                 1300                 1305         


<210>  5
<211>  1997
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Leu Leu Ile His Leu Lys Thr Val Ser Glu Leu Arg Gly Arg 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Asp Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Met Leu Glu Ile 
    50                  55                  60                  


Gln Val Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Arg Met Val Leu Gln Lys Val Val Glu Glu Ser His Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Ile Asp Asp Asn Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Cys Val Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Ser Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Glu Lys 
    130                 135                 140                 


Asp Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Ser 
145                 150                 155                 160 


Arg Pro Pro Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe 
                165                 170                 175     


Ser Ala Met Lys Leu Gly Lys Asn Arg Ser His Lys Glu Glu Pro Gln 
            180                 185                 190         


Arg Pro Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu 
        195                 200                 205             


Ala Ile Arg Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala 
    210                 215                 220                 


Ser Val Thr Ala Leu Thr Thr Asn Val Ser Asn Lys Arg Ser Lys Pro 
225                 230                 235                 240 


Asp Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val 
                245                 250                 255     


Ser Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp 
            260                 265                 270         


Pro Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met 
        275                 280                 285             


Lys Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp 
    290                 295                 300                 


Phe His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser 
305                 310                 315                 320 


Val Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser 
                325                 330                 335     


Phe Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe 
            340                 345                 350         


His His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ser Gly 
        355                 360                 365             


Leu Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp 
    370                 375                 380                 


Asn Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile 
385                 390                 395                 400 


Glu Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp 
                405                 410                 415     


Ala Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met 
            420                 425                 430         


Asn Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn 
        435                 440                 445             


Lys Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys 
    450                 455                 460                 


Gly Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu 
465                 470                 475                 480 


Gln Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys 
                485                 490                 495     


Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr 
            500                 505                 510         


His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe 
        515                 520                 525             


Leu Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg 
    530                 535                 540                 


Asn Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly 
545                 550                 555                 560 


Glu Gly Val Ser Phe Arg Ala Arg Leu Leu Leu Gly Leu Ala Val Glu 
                565                 570                 575     


Ile Val Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln 
            580                 585                 590         


Val Glu Gln Ala Thr Pro Ile Ser Glu Ser Cys Ala Gly Lys Met Glu 
        595                 600                 605             


Glu Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg 
    610                 615                 620                 


Arg Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr 
625                 630                 635                 640 


Gly Asn Glu Val Asp Gly Leu Ser Arg Pro Gln Arg Pro Arg Pro Arg 
                645                 650                 655     


Lys Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ala Ser 
            660                 665                 670         


Asp Asp Glu Ala Gly Asp Ala Gly Asp Leu Ala Ser Val Ser Ser Thr 
        675                 680                 685             


Pro Pro Met Arg Pro Gln Val Thr Asp Arg Asn Tyr Phe His Leu Pro 
    690                 695                 700                 


Tyr Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp 
705                 710                 715                 720 


Gln Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp 
                725                 730                 735     


Lys Leu Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu 
            740                 745                 750         


Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser 
        755                 760                 765             


Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His 
    770                 775                 780                 


Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg 
785                 790                 795                 800 


Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val 
                805                 810                 815     


Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu 
            820                 825                 830         


Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp 
        835                 840                 845             


Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg 
    850                 855                 860                 


Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly 
865                 870                 875                 880 


Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys 
                885                 890                 895     


Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu 
            900                 905                 910         


Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly 
        915                 920                 925             


Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu 
    930                 935                 940                 


His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe 
945                 950                 955                 960 


Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp 
                965                 970                 975     


Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln 
            980                 985                 990         


Ser Gln Cys Thr Glu Val Leu Asn  Glu Thr Leu Cys Pro  Thr Trp Asp 
        995                 1000                 1005             


Gln Met  Leu Val Phe Asp Asn  Leu Glu Leu Tyr Gly  Glu Ala His 
    1010                 1015                 1020             


Glu Leu  Arg Asp Asp Pro Pro  Ile Ile Val Ile Glu  Ile Tyr Asp 
    1025                 1030                 1035             


Gln Asp  Ser Met Gly Lys Ala  Asp Phe Met Gly Arg  Thr Phe Ala 
    1040                 1045                 1050             


Lys Pro  Leu Val Lys Met Ala  Asp Glu Ala Tyr Cys  Pro Pro Arg 
    1055                 1060                 1065             


Phe Pro  Pro Gln Leu Glu Tyr  Tyr Gln Ile Tyr Arg  Gly Asn Ala 
    1070                 1075                 1080             


Thr Ala  Gly Asp Leu Leu Ala  Ala Phe Glu Leu Leu  Gln Ile Gly 
    1085                 1090                 1095             


Pro Ala  Gly Lys Ala Asp Leu  Pro Pro Ile Asn Gly  Pro Val Asp 
    1100                 1105                 1110             


Val Asp  Arg Gly Pro Ile Met  Pro Val Pro Met Gly  Ile Arg Pro 
    1115                 1120                 1125             


Val Leu  Ser Lys Tyr Arg Val  Glu Val Leu Phe Trp  Gly Leu Arg 
    1130                 1135                 1140             


Asp Leu  Lys Arg Val Asn Leu  Ala Gln Val Asp Arg  Pro Arg Val 
    1145                 1150                 1155             


Asp Ile  Glu Cys Ala Gly Lys  Gly Val Gln Ser Ser  Leu Ile His 
    1160                 1165                 1170             


Asn Tyr  Lys Lys Asn Pro Asn  Phe Asn Thr Leu Val  Lys Trp Phe 
    1175                 1180                 1185             


Glu Val  Asp Leu Pro Glu Asn  Glu Leu Leu His Pro  Pro Leu Asn 
    1190                 1195                 1200             


Ile Arg  Val Val Asp Cys Arg  Ala Phe Gly Arg Tyr  Thr Leu Val 
    1205                 1210                 1215             


Gly Ser  His Ala Val Ser Ser  Leu Arg Arg Phe Ile  Tyr Arg Pro 
    1220                 1225                 1230             


Pro Asp  Arg Ser Ala Pro Ser  Trp Asn Thr Thr Val  Arg Leu Leu 
    1235                 1240                 1245             


Arg Arg  Cys Arg Val Leu Cys  Asn Gly Gly Ser Ser  Ser His Ser 
    1250                 1255                 1260             


Thr Gly  Glu Val Val Val Thr  Met Glu Pro Glu Val  Pro Ile Lys 
    1265                 1270                 1275             


Lys Leu  Glu Thr Met Val Lys  Leu Asp Ala Thr Ser  Glu Ala Val 
    1280                 1285                 1290             


Val Lys  Val Asp Val Ala Glu  Glu Glu Lys Glu Lys  Lys Lys Lys 
    1295                 1300                 1305             


Lys Lys  Gly Thr Ala Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu 
    1310                 1315                 1320             


Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr 
    1325                 1330                 1335             


Met Lys  Glu Gln Leu Arg Gln  Gln Glu Pro Ser Gly  Ile Asp Leu 
    1340                 1345                 1350             


Glu Glu  Lys Glu Glu Val Asp  Asn Thr Glu Gly Leu  Lys Gly Ser 
    1355                 1360                 1365             


Met Lys  Gly Lys Glu Lys Ala  Arg Ala Ala Lys Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Lys  Thr Gln Ser Ser Gly  Ser Gly Gln Gly Ser  Glu Ala Pro 
    1385                 1390                 1395             


Glu Lys  Lys Lys Pro Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys 
    1400                 1405                 1410             


Glu Leu  Glu Ser Glu Phe Asp  Asn Phe Glu Asp Trp  Leu His Thr 
    1415                 1420                 1425             


Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser 
    1430                 1435                 1440             


Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys 
    1445                 1450                 1455             


Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly 
    1460                 1465                 1470             


Tyr Asp  Ser Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp 
    1475                 1480                 1485             


Pro Ile  Asn Val Leu Val Arg  Val Tyr Val Val Arg  Ala Thr Asp 
    1490                 1495                 1500             


Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala 
    1505                 1510                 1515             


Ile Arg  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile 
    1520                 1525                 1530             


Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu 
    1535                 1540                 1545             


Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp 
    1550                 1555                 1560             


Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile 
    1565                 1570                 1575             


Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly 
    1580                 1585                 1590             


Ile Ala  Gln Thr Tyr Ser Thr  His Gly Tyr Asn Ile  Trp Arg Asp 
    1595                 1600                 1605             


Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys Asp Gly 
    1610                 1615                 1620             


Lys Val  Asp Gly Pro His Phe  Gly Pro Pro Gly Arg  Val Lys Val 
    1625                 1630                 1635             


Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn 
    1640                 1645                 1650             


Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Leu Ala Leu 
    1655                 1660                 1665             


Arg His  Trp Glu Asp Ile Pro  Arg Ala Gly Cys Arg  Leu Val Pro 
    1670                 1675                 1680             


Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
    1685                 1690                 1695             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1700                 1705                 1710             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1715                 1720                 1725             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1730                 1735                 1740             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1745                 1750                 1755             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1760                 1765                 1770             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1775                 1780                 1785             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1790                 1795                 1800             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1805                 1810                 1815             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1820                 1825                 1830             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1835                 1840                 1845             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1850                 1855                 1860             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1865                 1870                 1875             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1880                 1885                 1890             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1895                 1900                 1905             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1910                 1915                 1920             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1925                 1930                 1935             


Arg Pro  Asp Thr Ala Phe Val  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1940                 1945                 1950             


Ile Lys  Tyr Leu Ile Cys Thr  Arg Tyr Lys Trp Leu  Ile Ile Lys 
    1955                 1960                 1965             


Ile Val  Leu Ala Leu Leu Gly  Leu Leu Met Leu Gly  Leu Phe Leu 
    1970                 1975                 1980             


Tyr Ser  Leu Pro Gly Tyr Met  Val Lys Lys Leu Leu  Gly Ala 
    1985                 1990                 1995         


<210>  6
<211>  1997
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Leu Ile Val His Leu Lys Thr Val Ser Glu Leu Arg Gly Lys 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Gly Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Val Leu Glu Ile 
    50                  55                  60                  


Gln Ile Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Cys Met Val Leu Gln Lys Val Val Glu Glu Asn Arg Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Met Asp Asp Ser Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Ser Met Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Pro Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Lys Asp 
    130                 135                 140                 


Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Thr Arg 
145                 150                 155                 160 


Ile Ser Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe Ser 
                165                 170                 175     


Ala Met Lys Leu Gly Lys Thr Arg Ser His Lys Glu Glu Pro Gln Arg 
            180                 185                 190         


Gln Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu Ala 
        195                 200                 205             


Ile Gln Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala Ser 
    210                 215                 220                 


Val Thr Ala Leu Thr Ser Asn Val Ser Asn Lys Arg Ser Lys Pro Asp 
225                 230                 235                 240 


Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val Ser 
                245                 250                 255     


Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp Pro 
            260                 265                 270         


Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met Lys 
        275                 280                 285             


Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp Phe 
    290                 295                 300                 


His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser Val 
305                 310                 315                 320 


Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser Phe 
                325                 330                 335     


Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe His 
            340                 345                 350         


His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ala Gly Leu 
        355                 360                 365             


Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp Asn 
    370                 375                 380                 


Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile Glu 
385                 390                 395                 400 


Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp Ala 
                405                 410                 415     


Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met Asn 
            420                 425                 430         


Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn Lys 
        435                 440                 445             


Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys Gly 
    450                 455                 460                 


Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu Gln 
465                 470                 475                 480 


Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys Val 
                485                 490                 495     


Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr His 
            500                 505                 510         


Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe Leu 
        515                 520                 525             


Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg Asn 
    530                 535                 540                 


Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly Glu 
545                 550                 555                 560 


Gly Val Ser Phe Arg Ala Arg Leu Met Leu Gly Leu Ala Val Glu Ile 
                565                 570                 575     


Leu Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln Val 
            580                 585                 590         


Glu Gln Ala Thr Pro Val Ser Glu Ser Cys Thr Gly Arg Met Glu Glu 
        595                 600                 605             


Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg Lys 
    610                 615                 620                 


Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr Gly 
625                 630                 635                 640 


Asn Glu Val Asp Gly Met Ser Arg Pro Leu Arg Pro Arg Pro Arg Lys 
                645                 650                 655     


Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ser Ser Asp 
            660                 665                 670         


Asp Glu Gly Asp Glu Ala Gly Asp Leu Ala Ser Val Ser Ser Thr Pro 
        675                 680                 685             


Pro Met Arg Pro Gln Ile Thr Asp Arg Asn Tyr Phe His Leu Pro Tyr 
    690                 695                 700                 


Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp Gln 
705                 710                 715                 720 


Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp Lys 
                725                 730                 735     


Leu Glu Glu Gly Leu Asn Asp Val Gln Glu Met Ile Lys Thr Glu Lys 
            740                 745                 750         


Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys 
        755                 760                 765             


Gly Cys His Arg Phe Leu Ser Leu Ser Asp Lys Asp Gln Gly Arg Ser 
    770                 775                 780                 


Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu 
785                 790                 795                 800 


Leu Glu Ser Met Gly Gln Gln Ala Lys Ser Leu Arg Ala Gln Val Lys 
                805                 810                 815     


Arg His Thr Val Arg Asp Lys Leu Arg Ser Cys Gln Asn Phe Leu Gln 
            820                 825                 830         


Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Val 
        835                 840                 845             


Phe Ile Trp Met Met Ser Asn Asn Lys Arg Ile Ala Tyr Ala Arg Val 
    850                 855                 860                 


Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Leu Gly Lys 
865                 870                 875                 880 


Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg 
                885                 890                 895     


Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Leu Glu Leu Tyr 
            900                 905                 910         


Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Asp Phe Leu Cys Gly Leu 
        915                 920                 925             


Pro Cys Gly Phe Glu Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His 
    930                 935                 940                 


Ser Phe Pro Pro Ile Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln 
945                 950                 955                 960 


Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser 
                965                 970                 975     


Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln Ser 
            980                 985                 990         


Gln Cys Thr Glu Val Leu Asn Glu  Thr Leu Cys Pro Thr  Trp Asp Gln 
        995                 1000                 1005             


Met Leu  Val Phe Asp Asn Leu  Glu Leu Tyr Gly Glu  Ala His Glu 
    1010                 1015                 1020             


Leu Arg  Asp Asp Pro Pro Ile  Ile Val Ile Glu Ile  Tyr Asp Gln 
    1025                 1030                 1035             


Asp Ser  Met Gly Lys Ala Asp  Phe Met Gly Arg Thr  Phe Ala Lys 
    1040                 1045                 1050             


Pro Leu  Val Lys Met Ala Asp  Glu Ala Tyr Cys Pro  Pro Arg Phe 
    1055                 1060                 1065             


Pro Pro  Gln Leu Glu Tyr Tyr  Gln Ile Tyr Arg Gly  Ser Ala Thr 
    1070                 1075                 1080             


Ala Gly  Asp Leu Leu Ala Ala  Phe Glu Leu Leu Gln  Ile Gly Pro 
    1085                 1090                 1095             


Ser Gly  Lys Ala Asp Leu Pro  Pro Ile Asn Gly Pro  Val Asp Met 
    1100                 1105                 1110             


Asp Arg  Gly Pro Ile Met Pro  Val Pro Val Gly Ile  Arg Pro Val 
    1115                 1120                 1125             


Leu Ser  Lys Tyr Arg Val Glu  Val Leu Phe Trp Gly  Leu Arg Asp 
    1130                 1135                 1140             


Leu Lys  Arg Val Asn Leu Ala  Gln Val Asp Arg Pro  Arg Val Asp 
    1145                 1150                 1155             


Ile Glu  Cys Ala Gly Lys Gly  Val Gln Ser Ser Leu  Ile His Asn 
    1160                 1165                 1170             


Tyr Lys  Lys Asn Pro Asn Phe  Asn Thr Leu Val Lys  Trp Phe Glu 
    1175                 1180                 1185             


Val Asp  Leu Pro Glu Asn Glu  Leu Leu His Pro Pro  Leu Asn Ile 
    1190                 1195                 1200             


Arg Val  Val Asp Cys Arg Ala  Phe Gly Arg Tyr Thr  Leu Val Gly 
    1205                 1210                 1215             


Ser His  Ala Val Ser Ser Leu  Arg Arg Phe Ile Tyr  Arg Pro Pro 
    1220                 1225                 1230             


Asp Arg  Ser Ala Pro Asn Trp  Asn Thr Thr Val Arg  Leu Leu Arg 
    1235                 1240                 1245             


Gly Cys  His Arg Leu Arg Asn  Gly Gly Pro Ser Ser  Arg Pro Thr 
    1250                 1255                 1260             


Gly Glu  Val Val Val Ser Met  Glu Pro Glu Glu Pro  Val Lys Lys 
    1265                 1270                 1275             


Leu Glu  Thr Met Val Lys Leu  Asp Ala Thr Ser Asp  Ala Val Val 
    1280                 1285                 1290             


Lys Val  Asp Val Ala Glu Asp  Glu Lys Glu Arg Lys  Lys Lys Lys 
    1295                 1300                 1305             


Lys Lys  Gly Pro Ser Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu 
    1310                 1315                 1320             


Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr 
    1325                 1330                 1335             


Met Lys  Glu Gln Leu Arg Gln  His Glu Thr Ser Gly  Thr Asp Leu 
    1340                 1345                 1350             


Glu Glu  Lys Glu Glu Met Glu  Ser Ala Glu Gly Leu  Lys Gly Pro 
    1355                 1360                 1365             


Met Lys  Ser Lys Glu Lys Ser  Arg Ala Ala Lys Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Lys  Asn Gln Ser Pro Gly  Pro Gly Gln Gly Ser  Glu Ala Pro 
    1385                 1390                 1395             


Glu Lys  Lys Lys Ala Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys 
    1400                 1405                 1410             


Glu Leu  Glu Ser Glu Phe Asp  Ser Phe Glu Asp Trp  Leu His Thr 
    1415                 1420                 1425             


Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser 
    1430                 1435                 1440             


Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys 
    1445                 1450                 1455             


Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly 
    1460                 1465                 1470             


Tyr Asp  Pro Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp 
    1475                 1480                 1485             


Pro Ile  Asn Val Leu Val Arg  Ile Tyr Val Val Arg  Ala Thr Asp 
    1490                 1495                 1500             


Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala 
    1505                 1510                 1515             


Ile Lys  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile 
    1520                 1525                 1530             


Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu 
    1535                 1540                 1545             


Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp 
    1550                 1555                 1560             


Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile 
    1565                 1570                 1575             


Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly 
    1580                 1585                 1590             


Ile Ala  Gln Thr Tyr Ser Ile  His Gly Tyr Asn Ile  Trp Arg Asp 
    1595                 1600                 1605             


Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys Glu Gly 
    1610                 1615                 1620             


Lys Val  Asp Gly Pro His Phe  Gly Pro His Gly Arg  Val Arg Val 
    1625                 1630                 1635             


Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn 
    1640                 1645                 1650             


Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Ser Ala Leu 
    1655                 1660                 1665             


Arg His  Trp Glu Asp Ile Pro  Arg Val Gly Cys Arg  Leu Val Pro 
    1670                 1675                 1680             


Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
    1685                 1690                 1695             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1700                 1705                 1710             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1715                 1720                 1725             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Val Trp Asn  Thr Asp Glu 
    1730                 1735                 1740             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1745                 1750                 1755             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1760                 1765                 1770             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1775                 1780                 1785             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1790                 1795                 1800             


Glu Lys  Ile Val Met Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1805                 1810                 1815             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1820                 1825                 1830             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1835                 1840                 1845             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1850                 1855                 1860             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1865                 1870                 1875             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1880                 1885                 1890             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1895                 1900                 1905             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1910                 1915                 1920             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1925                 1930                 1935             


Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1940                 1945                 1950             


Ala Arg  Tyr Phe Leu Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys 
    1955                 1960                 1965             


Phe Leu  Leu Leu Phe Leu Leu  Leu Leu Leu Phe Ala  Leu Phe Leu 
    1970                 1975                 1980             


Tyr Ser  Leu Pro Gly Tyr Leu  Ala Lys Lys Ile Leu  Gly Ala 
    1985                 1990                 1995         


<210>  7
<211>  1977
<212>  PRT
<213>  Mus musculus

<400>  7

Met Ala Leu Ile Val His Leu Lys Thr Val Ser Glu Leu Arg Gly Lys 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Gly Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Val Leu Glu Ile 
    50                  55                  60                  


Gln Ile Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Cys Met Val Leu Gln Lys Val Val Glu Glu Asn Arg Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Met Asp Asp Ser Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Ser Met Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Pro Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Lys Asp 
    130                 135                 140                 


Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Thr Arg 
145                 150                 155                 160 


Ile Ser Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe Ser 
                165                 170                 175     


Ala Met Lys Leu Gly Lys Thr Arg Ser His Lys Glu Glu Pro Gln Arg 
            180                 185                 190         


Gln Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu Ala 
        195                 200                 205             


Ile Gln Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala Ser 
    210                 215                 220                 


Val Thr Ala Leu Thr Ser Asn Val Ser Asn Lys Arg Ser Lys Pro Asp 
225                 230                 235                 240 


Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val Ser 
                245                 250                 255     


Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp Pro 
            260                 265                 270         


Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met Lys 
        275                 280                 285             


Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp Phe 
    290                 295                 300                 


His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser Val 
305                 310                 315                 320 


Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser Phe 
                325                 330                 335     


Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe His 
            340                 345                 350         


His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ala Gly Leu 
        355                 360                 365             


Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp Asn 
    370                 375                 380                 


Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile Glu 
385                 390                 395                 400 


Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp Ala 
                405                 410                 415     


Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met Asn 
            420                 425                 430         


Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn Lys 
        435                 440                 445             


Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys Gly 
    450                 455                 460                 


Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu Gln 
465                 470                 475                 480 


Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys Val 
                485                 490                 495     


Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr His 
            500                 505                 510         


Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe Leu 
        515                 520                 525             


Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg Asn 
    530                 535                 540                 


Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly Glu 
545                 550                 555                 560 


Gly Val Ser Phe Arg Ala Arg Leu Met Leu Gly Leu Ala Val Glu Ile 
                565                 570                 575     


Leu Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln Val 
            580                 585                 590         


Glu Gln Ala Thr Pro Val Ser Glu Ser Cys Thr Gly Arg Met Glu Glu 
        595                 600                 605             


Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg Lys 
    610                 615                 620                 


Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr Gly 
625                 630                 635                 640 


Asn Glu Val Asp Gly Met Ser Arg Pro Leu Arg Pro Arg Pro Arg Lys 
                645                 650                 655     


Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ser Ser Asp 
            660                 665                 670         


Asp Glu Gly Asp Glu Ala Gly Asp Leu Ala Ser Val Ser Ser Thr Pro 
        675                 680                 685             


Pro Met Arg Pro Gln Ile Thr Asp Arg Asn Tyr Phe His Leu Pro Tyr 
    690                 695                 700                 


Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp Gln 
705                 710                 715                 720 


Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp Lys 
                725                 730                 735     


Leu Glu Glu Gly Leu Asn Asp Val Gln Glu Met Ile Lys Thr Glu Lys 
            740                 745                 750         


Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys 
        755                 760                 765             


Gly Cys His Arg Phe Leu Ser Leu Ser Asp Lys Asp Gln Gly Arg Ser 
    770                 775                 780                 


Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu 
785                 790                 795                 800 


Leu Glu Ser Met Gly Gln Gln Ala Lys Ser Leu Arg Ala Gln Val Lys 
                805                 810                 815     


Arg His Thr Val Arg Asp Lys Leu Arg Ser Cys Gln Asn Phe Leu Gln 
            820                 825                 830         


Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Val 
        835                 840                 845             


Phe Ile Trp Met Met Ser Asn Asn Lys Arg Ile Ala Tyr Ala Arg Val 
    850                 855                 860                 


Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Leu Gly Lys 
865                 870                 875                 880 


Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg 
                885                 890                 895     


Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Leu Glu Leu Tyr 
            900                 905                 910         


Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Asp Phe Leu Cys Gly Leu 
        915                 920                 925             


Pro Cys Gly Phe Glu Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His 
    930                 935                 940                 


Ser Phe Pro Pro Ile Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln 
945                 950                 955                 960 


Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser 
                965                 970                 975     


Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln Ser 
            980                 985                 990         


Gln Cys Thr Glu Val Leu Asn Glu  Thr Leu Cys Pro Thr  Trp Asp Gln 
        995                 1000                 1005             


Met Leu  Val Phe Asp Asn Leu  Glu Leu Tyr Gly Glu  Ala His Glu 
    1010                 1015                 1020             


Leu Arg  Asp Asp Pro Pro Ile  Ile Val Ile Glu Ile  Tyr Asp Gln 
    1025                 1030                 1035             


Asp Ser  Met Gly Lys Ala Asp  Phe Met Gly Arg Thr  Phe Ala Lys 
    1040                 1045                 1050             


Pro Leu  Val Lys Met Ala Asp  Glu Ala Tyr Cys Pro  Pro Arg Phe 
    1055                 1060                 1065             


Pro Pro  Gln Leu Glu Tyr Tyr  Gln Ile Tyr Arg Gly  Ser Ala Thr 
    1070                 1075                 1080             


Ala Gly  Asp Leu Leu Ala Ala  Phe Glu Leu Leu Gln  Ile Gly Pro 
    1085                 1090                 1095             


Ser Gly  Lys Ala Asp Leu Pro  Pro Ile Asn Gly Pro  Val Asp Met 
    1100                 1105                 1110             


Asp Arg  Gly Pro Ile Met Pro  Val Pro Val Gly Ile  Arg Pro Val 
    1115                 1120                 1125             


Leu Ser  Lys Tyr Arg Val Glu  Val Leu Phe Trp Gly  Leu Arg Asp 
    1130                 1135                 1140             


Leu Lys  Arg Val Asn Leu Ala  Gln Val Asp Arg Pro  Arg Val Asp 
    1145                 1150                 1155             


Ile Glu  Cys Ala Gly Lys Gly  Val Gln Ser Ser Leu  Ile His Asn 
    1160                 1165                 1170             


Tyr Lys  Lys Asn Pro Asn Phe  Asn Thr Leu Val Lys  Trp Phe Glu 
    1175                 1180                 1185             


Val Asp  Leu Pro Glu Asn Glu  Leu Leu His Pro Pro  Leu Asn Ile 
    1190                 1195                 1200             


Arg Val  Val Asp Cys Arg Ala  Phe Gly Arg Tyr Thr  Leu Val Gly 
    1205                 1210                 1215             


Ser His  Ala Val Ser Ser Leu  Arg Arg Phe Ile Tyr  Arg Pro Pro 
    1220                 1225                 1230             


Asp Arg  Ser Ala Pro Asn Trp  Asn Thr Thr Gly Glu  Val Val Val 
    1235                 1240                 1245             


Ser Met  Glu Pro Glu Glu Pro  Val Lys Lys Leu Glu  Thr Met Val 
    1250                 1255                 1260             


Lys Leu  Asp Ala Thr Ser Asp  Ala Val Val Lys Val  Asp Val Ala 
    1265                 1270                 1275             


Glu Asp  Glu Lys Glu Arg Lys  Lys Lys Lys Lys Lys  Gly Pro Ser 
    1280                 1285                 1290             


Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu Ser Met  Leu Asp Trp 
    1295                 1300                 1305             


Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr Met Lys  Glu Gln Leu 
    1310                 1315                 1320             


Arg Gln  His Glu Thr Ser Gly  Thr Asp Leu Glu Glu  Lys Glu Glu 
    1325                 1330                 1335             


Met Glu  Ser Ala Glu Gly Leu  Lys Gly Pro Met Lys  Ser Lys Glu 
    1340                 1345                 1350             


Lys Ser  Arg Ala Ala Lys Glu  Glu Lys Lys Lys Lys  Asn Gln Ser 
    1355                 1360                 1365             


Pro Gly  Pro Gly Gln Gly Ser  Glu Ala Pro Glu Lys  Lys Lys Ala 
    1370                 1375                 1380             


Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys Glu Leu  Glu Ser Glu 
    1385                 1390                 1395             


Phe Asp  Ser Phe Glu Asp Trp  Leu His Thr Phe Asn  Leu Leu Arg 
    1400                 1405                 1410             


Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser Thr Glu  Glu Glu Arg 
    1415                 1420                 1425             


Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys Val Tyr  Lys Val Pro 
    1430                 1435                 1440             


Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly Tyr Asp  Pro Thr Tyr 
    1445                 1450                 1455             


Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp Pro Ile  Asn Val Leu 
    1460                 1465                 1470             


Val Arg  Ile Tyr Val Val Arg  Ala Thr Asp Leu His  Pro Ala Asp 
    1475                 1480                 1485             


Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala Ile Lys  Leu Gly Lys 
    1490                 1495                 1500             


Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile Ser Lys  Gln Leu Asn 
    1505                 1510                 1515             


Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu Ala Ser  Phe Pro Met 
    1520                 1525                 1530             


Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp Trp Asp  Leu Val Gly 
    1535                 1540                 1545             


Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile Asp Leu  Glu Asn Arg 
    1550                 1555                 1560             


Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly Ile Ala  Gln Thr Tyr 
    1565                 1570                 1575             


Ser Ile  His Gly Tyr Asn Ile  Trp Arg Asp Pro Met  Lys Pro Ser 
    1580                 1585                 1590             


Gln Ile  Leu Thr Arg Leu Cys  Lys Glu Gly Lys Val  Asp Gly Pro 
    1595                 1600                 1605             


His Phe  Gly Pro His Gly Arg  Val Arg Val Ala Asn  Arg Val Phe 
    1610                 1615                 1620             


Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn Gly Gln  Arg Lys Pro 
    1625                 1630                 1635             


Thr Asp  Glu His Val Ala Leu  Ser Ala Leu Arg His  Trp Glu Asp 
    1640                 1645                 1650             


Ile Pro  Arg Val Gly Cys Arg  Leu Val Pro Glu His  Val Glu Thr 
    1655                 1660                 1665             


Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly Ile Glu  Gln Gly Arg 
    1670                 1675                 1680             


Leu Glu  Leu Trp Val Asp Met  Phe Pro Met Asp Met  Pro Ala Pro 
    1685                 1690                 1695             


Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys Pro Lys  Lys Tyr Glu 
    1700                 1705                 1710             


Leu Arg  Val Ile Val Trp Asn  Thr Asp Glu Val Val  Leu Glu Asp 
    1715                 1720                 1725             


Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser Asp Ile  Phe Val Arg 
    1730                 1735                 1740             


Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys Gln Asp  Thr Asp Val 
    1745                 1750                 1755             


His Tyr  His Ser Leu Thr Gly  Glu Gly Asn Phe Asn  Trp Arg Tyr 
    1760                 1765                 1770             


Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu Glu Lys  Ile Val Met 
    1775                 1780                 1785             


Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp Glu Thr  Glu Tyr Lys 
    1790                 1795                 1800             


Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp Asp Ala  Asp His Phe 
    1805                 1810                 1815             


Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu Leu Asp  Leu Asn Arg 
    1820                 1825                 1830             


Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln Cys Thr  Met Glu Met 
    1835                 1840                 1845             


Ala Thr  Gly Glu Val Asp Val  Pro Leu Val Ser Ile  Phe Lys Gln 
    1850                 1855                 1860             


Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu Ala Arg  Asn Glu Asn 
    1865                 1870                 1875             


Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu Ala Glu  Leu His Leu 
    1880                 1885                 1890             


Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro Val Gly  Leu Ala Arg 
    1895                 1900                 1905             


Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn Arg Pro  Asp Thr Ser 
    1910                 1915                 1920             


Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser Ala Arg  Tyr Phe Leu 
    1925                 1930                 1935             


Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys Phe Leu  Leu Leu Phe 
    1940                 1945                 1950             


Leu Leu  Leu Leu Leu Phe Ala  Leu Phe Leu Tyr Ser  Leu Pro Gly 
    1955                 1960                 1965             


Tyr Leu  Ala Lys Lys Ile Leu  Gly Ala 
    1970                 1975         


<210>  8
<211>  1992
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ala Leu Ile Val His Leu Lys Thr Val Ser Glu Leu Arg Gly Lys 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Gly Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Val Leu Glu Ile 
    50                  55                  60                  


Gln Ile Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Cys Met Val Leu Gln Lys Val Val Glu Glu Asn Arg Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Met Asp Asp Ser Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Ser Met Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Pro Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Lys Asp 
    130                 135                 140                 


Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Thr Arg 
145                 150                 155                 160 


Ile Ser Gly Glu Lys Ser Phe Arg Ser Lys Gly Arg Glu Lys Thr Lys 
                165                 170                 175     


Gly Gly Arg Asp Gly Glu His Lys Ala Gly Arg Ser Val Phe Ser Ala 
            180                 185                 190         


Met Lys Leu Gly Lys Thr Arg Ser His Lys Glu Glu Pro Gln Arg Gln 
        195                 200                 205             


Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu Ala Ile 
    210                 215                 220                 


Gln Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala Ser Val 
225                 230                 235                 240 


Thr Ala Leu Thr Ser Asn Val Ser Asn Lys Arg Ser Lys Pro Asp Ile 
                245                 250                 255     


Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val Ser Ile 
            260                 265                 270         


Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp Pro Val 
        275                 280                 285             


Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met Lys Glu 
    290                 295                 300                 


Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp Phe His 
305                 310                 315                 320 


Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser Val Ile 
                325                 330                 335     


His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser Phe Lys 
            340                 345                 350         


Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe His His 
        355                 360                 365             


Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ala Gly Leu Lys 
    370                 375                 380                 


Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp Asn Ile 
385                 390                 395                 400 


Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile Glu Gly 
                405                 410                 415     


Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp Ala Arg 
            420                 425                 430         


Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met Asn Thr 
        435                 440                 445             


Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn Lys Asp 
    450                 455                 460                 


Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys Gly Lys 
465                 470                 475                 480 


Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu Gln Val 
                485                 490                 495     


Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys Val Gln 
            500                 505                 510         


Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr His Phe 
        515                 520                 525             


Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe Leu Pro 
    530                 535                 540                 


Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg Asn Tyr 
545                 550                 555                 560 


Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly Glu Gly 
                565                 570                 575     


Val Ser Phe Arg Ala Arg Leu Met Leu Gly Leu Ala Val Glu Ile Leu 
            580                 585                 590         


Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln Val Glu 
        595                 600                 605             


Gln Ala Thr Pro Val Ser Glu Ser Cys Thr Gly Arg Met Glu Glu Phe 
    610                 615                 620                 


Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg Lys Asn 
625                 630                 635                 640 


Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr Gly Asn 
                645                 650                 655     


Glu Val Asp Gly Met Ser Arg Pro Leu Arg Pro Arg Pro Arg Lys Glu 
            660                 665                 670         


Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ser Ser Asp Asp 
        675                 680                 685             


Glu Gly Asp Glu Ala Gly Asp Leu Ala Ser Val Ser Ser Thr Pro Pro 
    690                 695                 700                 


Met Arg Pro Gln Ile Thr Asp Arg Asn Tyr Phe His Leu Pro Tyr Leu 
705                 710                 715                 720 


Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp Gln Arg 
                725                 730                 735     


Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp Lys Leu 
            740                 745                 750         


Glu Glu Gly Leu Asn Asp Val Gln Glu Met Ile Lys Thr Glu Lys Ser 
        755                 760                 765             


Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys Gly 
    770                 775                 780                 


Cys His Arg Phe Leu Ser Leu Ser Asp Lys Asp Gln Gly Arg Ser Ser 
785                 790                 795                 800 


Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu Leu 
                805                 810                 815     


Glu Ser Met Gly Gln Gln Ala Lys Ser Leu Arg Ala Gln Val Lys Arg 
            820                 825                 830         


His Thr Val Arg Asp Lys Leu Arg Ser Cys Gln Asn Phe Leu Gln Lys 
        835                 840                 845             


Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Val Phe 
    850                 855                 860                 


Ile Trp Met Met Ser Asn Asn Lys Arg Ile Ala Tyr Ala Arg Val Pro 
865                 870                 875                 880 


Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Leu Gly Lys Asp 
                885                 890                 895     


Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg Gly 
            900                 905                 910         


Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Leu Glu Leu Tyr Leu 
        915                 920                 925             


Trp Leu Gly Leu Ser Lys Gln Arg Lys Asp Phe Leu Cys Gly Leu Pro 
    930                 935                 940                 


Cys Gly Phe Glu Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His Ser 
945                 950                 955                 960 


Phe Pro Pro Ile Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln Leu 
                965                 970                 975     


Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser Ser 
            980                 985                 990         


Gly Leu Ser Asp Pro Phe Ala Arg  Val Phe Phe Ile Asn  Gln Ser Gln 
        995                 1000                 1005             


Cys Thr  Glu Val Leu Asn Glu  Thr Leu Cys Pro Thr  Trp Asp Gln 
    1010                 1015                 1020             


Met Leu  Val Phe Asp Asn Leu  Glu Leu Tyr Gly Glu  Ala His Glu 
    1025                 1030                 1035             


Leu Arg  Asp Asp Pro Pro Ile  Ile Val Ile Glu Ile  Tyr Asp Gln 
    1040                 1045                 1050             


Asp Ser  Met Gly Lys Ala Asp  Phe Met Gly Arg Thr  Phe Ala Lys 
    1055                 1060                 1065             


Pro Leu  Val Lys Met Ala Asp  Glu Ala Tyr Cys Pro  Pro Arg Phe 
    1070                 1075                 1080             


Pro Pro  Gln Leu Glu Tyr Tyr  Gln Ile Tyr Arg Gly  Ser Ala Thr 
    1085                 1090                 1095             


Ala Gly  Asp Leu Leu Ala Ala  Phe Glu Leu Leu Gln  Ile Gly Pro 
    1100                 1105                 1110             


Ser Gly  Lys Ala Asp Leu Pro  Pro Ile Asn Gly Pro  Val Asp Met 
    1115                 1120                 1125             


Asp Arg  Gly Pro Ile Met Pro  Val Pro Val Gly Ile  Arg Pro Val 
    1130                 1135                 1140             


Leu Ser  Lys Tyr Arg Val Glu  Val Leu Phe Trp Gly  Leu Arg Asp 
    1145                 1150                 1155             


Leu Lys  Arg Val Asn Leu Ala  Gln Val Asp Arg Pro  Arg Val Asp 
    1160                 1165                 1170             


Ile Glu  Cys Ala Gly Lys Gly  Val Gln Ser Ser Leu  Ile His Asn 
    1175                 1180                 1185             


Tyr Lys  Lys Asn Pro Asn Phe  Asn Thr Leu Val Lys  Trp Phe Glu 
    1190                 1195                 1200             


Val Asp  Leu Pro Glu Asn Glu  Leu Leu His Pro Pro  Leu Asn Ile 
    1205                 1210                 1215             


Arg Val  Val Asp Cys Arg Ala  Phe Gly Arg Tyr Thr  Leu Val Gly 
    1220                 1225                 1230             


Ser His  Ala Val Ser Ser Leu  Arg Arg Phe Ile Tyr  Arg Pro Pro 
    1235                 1240                 1245             


Asp Arg  Ser Ala Pro Asn Trp  Asn Thr Thr Gly Glu  Val Val Val 
    1250                 1255                 1260             


Ser Met  Glu Pro Glu Glu Pro  Val Lys Lys Leu Glu  Thr Met Val 
    1265                 1270                 1275             


Lys Leu  Asp Ala Thr Ser Asp  Ala Val Val Lys Val  Asp Val Ala 
    1280                 1285                 1290             


Glu Asp  Glu Lys Glu Arg Lys  Lys Lys Lys Lys Lys  Gly Pro Ser 
    1295                 1300                 1305             


Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu Ser Met  Leu Asp Trp 
    1310                 1315                 1320             


Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr Met Lys  Glu Gln Leu 
    1325                 1330                 1335             


Arg Gln  His Glu Thr Ser Gly  Thr Asp Leu Glu Glu  Lys Glu Glu 
    1340                 1345                 1350             


Met Glu  Ser Ala Glu Gly Leu  Lys Gly Pro Met Lys  Ser Lys Glu 
    1355                 1360                 1365             


Lys Ser  Arg Ala Ala Lys Glu  Glu Lys Lys Lys Lys  Asn Gln Ser 
    1370                 1375                 1380             


Pro Gly  Pro Gly Gln Gly Ser  Glu Ala Pro Glu Lys  Lys Lys Ala 
    1385                 1390                 1395             


Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys Glu Leu  Glu Ser Glu 
    1400                 1405                 1410             


Phe Asp  Ser Phe Glu Asp Trp  Leu His Thr Phe Asn  Leu Leu Arg 
    1415                 1420                 1425             


Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser Thr Glu  Glu Glu Arg 
    1430                 1435                 1440             


Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys Val Tyr  Lys Val Pro 
    1445                 1450                 1455             


Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly Tyr Asp  Pro Thr Tyr 
    1460                 1465                 1470             


Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp Pro Ile  Asn Val Leu 
    1475                 1480                 1485             


Val Arg  Ile Tyr Val Val Arg  Ala Thr Asp Leu His  Pro Ala Asp 
    1490                 1495                 1500             


Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala Ile Lys  Leu Gly Lys 
    1505                 1510                 1515             


Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile Ser Lys  Gln Leu Asn 
    1520                 1525                 1530             


Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu Ala Ser  Phe Pro Met 
    1535                 1540                 1545             


Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp Trp Asp  Leu Val Gly 
    1550                 1555                 1560             


Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile Asp Leu  Glu Asn Arg 
    1565                 1570                 1575             


Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly Ile Ala  Gln Thr Tyr 
    1580                 1585                 1590             


Ser Ile  His Gly Tyr Asn Ile  Trp Arg Asp Pro Met  Lys Pro Ser 
    1595                 1600                 1605             


Gln Ile  Leu Thr Arg Leu Cys  Lys Glu Gly Lys Val  Asp Gly Pro 
    1610                 1615                 1620             


His Phe  Gly Pro His Gly Arg  Val Arg Val Ala Asn  Arg Val Phe 
    1625                 1630                 1635             


Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn Gly Gln  Arg Lys Pro 
    1640                 1645                 1650             


Thr Asp  Glu His Val Ala Leu  Ser Ala Leu Arg His  Trp Glu Asp 
    1655                 1660                 1665             


Ile Pro  Arg Val Gly Cys Arg  Leu Val Pro Glu His  Val Glu Thr 
    1670                 1675                 1680             


Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly Ile Glu  Gln Gly Arg 
    1685                 1690                 1695             


Leu Glu  Leu Trp Val Asp Met  Phe Pro Met Asp Met  Pro Ala Pro 
    1700                 1705                 1710             


Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys Pro Lys  Lys Tyr Glu 
    1715                 1720                 1725             


Leu Arg  Val Ile Val Trp Asn  Thr Asp Glu Val Val  Leu Glu Asp 
    1730                 1735                 1740             


Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser Asp Ile  Phe Val Arg 
    1745                 1750                 1755             


Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys Gln Asp  Thr Asp Val 
    1760                 1765                 1770             


His Tyr  His Ser Leu Thr Gly  Glu Gly Asn Phe Asn  Trp Arg Tyr 
    1775                 1780                 1785             


Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu Glu Lys  Ile Val Met 
    1790                 1795                 1800             


Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp Glu Thr  Glu Tyr Lys 
    1805                 1810                 1815             


Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp Asp Ala  Asp His Phe 
    1820                 1825                 1830             


Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu Leu Asp  Leu Asn Arg 
    1835                 1840                 1845             


Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln Cys Thr  Met Glu Met 
    1850                 1855                 1860             


Ala Thr  Gly Glu Val Asp Val  Pro Leu Val Ser Ile  Phe Lys Gln 
    1865                 1870                 1875             


Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu Ala Arg  Asn Glu Asn 
    1880                 1885                 1890             


Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu Ala Glu  Leu His Leu 
    1895                 1900                 1905             


Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro Val Gly  Leu Ala Arg 
    1910                 1915                 1920             


Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn Arg Pro  Asp Thr Ala 
    1925                 1930                 1935             


Phe Val  Trp Phe Leu Asn Pro  Leu Lys Ser Ile Lys  Tyr Leu Ile 
    1940                 1945                 1950             


Cys Thr  Arg Tyr Lys Trp Leu  Ile Ile Lys Ile Val  Leu Ala Leu 
    1955                 1960                 1965             


Leu Gly  Leu Leu Met Leu Ala  Leu Phe Leu Tyr Ser  Leu Pro Gly 
    1970                 1975                 1980             


Tyr Met  Val Lys Lys Leu Leu  Gly Ala 
    1985                 1990         


<210>  9
<211>  1977
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ala Leu Ile Val His Leu Lys Thr Val Ser Glu Leu Arg Gly Lys 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Gly Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Val Leu Glu Ile 
    50                  55                  60                  


Gln Ile Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Cys Met Val Leu Gln Lys Val Val Glu Glu Asn Arg Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Met Asp Asp Ser Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Ser Met Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Pro Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Lys Asp 
    130                 135                 140                 


Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Thr Arg 
145                 150                 155                 160 


Ile Ser Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe Ser 
                165                 170                 175     


Ala Met Lys Leu Gly Lys Thr Arg Ser His Lys Glu Glu Pro Gln Arg 
            180                 185                 190         


Gln Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu Ala 
        195                 200                 205             


Ile Gln Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala Ser 
    210                 215                 220                 


Val Thr Ala Leu Thr Ser Asn Val Ser Asn Lys Arg Ser Lys Pro Asp 
225                 230                 235                 240 


Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val Ser 
                245                 250                 255     


Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp Pro 
            260                 265                 270         


Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met Lys 
        275                 280                 285             


Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp Phe 
    290                 295                 300                 


His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser Val 
305                 310                 315                 320 


Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser Phe 
                325                 330                 335     


Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe His 
            340                 345                 350         


His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ala Gly Leu 
        355                 360                 365             


Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp Asn 
    370                 375                 380                 


Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile Glu 
385                 390                 395                 400 


Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp Ala 
                405                 410                 415     


Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met Asn 
            420                 425                 430         


Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn Lys 
        435                 440                 445             


Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys Gly 
    450                 455                 460                 


Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu Gln 
465                 470                 475                 480 


Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys Val 
                485                 490                 495     


Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr His 
            500                 505                 510         


Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe Leu 
        515                 520                 525             


Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg Asn 
    530                 535                 540                 


Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly Glu 
545                 550                 555                 560 


Gly Val Ser Phe Arg Ala Arg Leu Met Leu Gly Leu Ala Val Glu Ile 
                565                 570                 575     


Leu Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln Val 
            580                 585                 590         


Glu Gln Ala Thr Pro Val Ser Glu Ser Cys Thr Gly Arg Met Glu Glu 
        595                 600                 605             


Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg Lys 
    610                 615                 620                 


Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr Gly 
625                 630                 635                 640 


Asn Glu Val Asp Gly Met Ser Arg Pro Leu Arg Pro Arg Pro Arg Lys 
                645                 650                 655     


Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ser Ser Asp 
            660                 665                 670         


Asp Glu Gly Asp Glu Ala Gly Asp Leu Ala Ser Val Ser Ser Thr Pro 
        675                 680                 685             


Pro Met Arg Pro Gln Ile Thr Asp Arg Asn Tyr Phe His Leu Pro Tyr 
    690                 695                 700                 


Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp Gln 
705                 710                 715                 720 


Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp Lys 
                725                 730                 735     


Leu Glu Glu Gly Leu Asn Asp Val Gln Glu Met Ile Lys Thr Glu Lys 
            740                 745                 750         


Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys 
        755                 760                 765             


Gly Cys His Arg Phe Leu Ser Leu Ser Asp Lys Asp Gln Gly Arg Ser 
    770                 775                 780                 


Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu 
785                 790                 795                 800 


Leu Glu Ser Met Gly Gln Gln Ala Lys Ser Leu Arg Ala Gln Val Lys 
                805                 810                 815     


Arg His Thr Val Arg Asp Lys Leu Arg Ser Cys Gln Asn Phe Leu Gln 
            820                 825                 830         


Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Val 
        835                 840                 845             


Phe Ile Trp Met Met Ser Asn Asn Lys Arg Ile Ala Tyr Ala Arg Val 
    850                 855                 860                 


Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Leu Gly Lys 
865                 870                 875                 880 


Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg 
                885                 890                 895     


Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Leu Glu Leu Tyr 
            900                 905                 910         


Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Asp Phe Leu Cys Gly Leu 
        915                 920                 925             


Pro Cys Gly Phe Glu Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His 
    930                 935                 940                 


Ser Phe Pro Pro Ile Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln 
945                 950                 955                 960 


Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser 
                965                 970                 975     


Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln Ser 
            980                 985                 990         


Gln Cys Thr Glu Val Leu Asn Glu  Thr Leu Cys Pro Thr  Trp Asp Gln 
        995                 1000                 1005             


Met Leu  Val Phe Asp Asn Leu  Glu Leu Tyr Gly Glu  Ala His Glu 
    1010                 1015                 1020             


Leu Arg  Asp Asp Pro Pro Ile  Ile Val Ile Glu Ile  Tyr Asp Gln 
    1025                 1030                 1035             


Asp Ser  Met Gly Lys Ala Asp  Phe Met Gly Arg Thr  Phe Ala Lys 
    1040                 1045                 1050             


Pro Leu  Val Lys Met Ala Asp  Glu Ala Tyr Cys Pro  Pro Arg Phe 
    1055                 1060                 1065             


Pro Pro  Gln Leu Glu Tyr Tyr  Gln Ile Tyr Arg Gly  Ser Ala Thr 
    1070                 1075                 1080             


Ala Gly  Asp Leu Leu Ala Ala  Phe Glu Leu Leu Gln  Ile Gly Pro 
    1085                 1090                 1095             


Ser Gly  Lys Ala Asp Leu Pro  Pro Ile Asn Gly Pro  Val Asp Met 
    1100                 1105                 1110             


Asp Arg  Gly Pro Ile Met Pro  Val Pro Val Gly Ile  Arg Pro Val 
    1115                 1120                 1125             


Leu Ser  Lys Tyr Arg Val Glu  Val Leu Phe Trp Gly  Leu Arg Asp 
    1130                 1135                 1140             


Leu Lys  Arg Val Asn Leu Ala  Gln Val Asp Arg Pro  Arg Val Asp 
    1145                 1150                 1155             


Ile Glu  Cys Ala Gly Lys Gly  Val Gln Ser Ser Leu  Ile His Asn 
    1160                 1165                 1170             


Tyr Lys  Lys Asn Pro Asn Phe  Asn Thr Leu Val Lys  Trp Phe Glu 
    1175                 1180                 1185             


Val Asp  Leu Pro Glu Asn Glu  Leu Leu His Pro Pro  Leu Asn Ile 
    1190                 1195                 1200             


Arg Val  Val Asp Cys Arg Ala  Phe Gly Arg Tyr Thr  Leu Val Gly 
    1205                 1210                 1215             


Ser His  Ala Val Ser Ser Leu  Arg Arg Phe Ile Tyr  Arg Pro Pro 
    1220                 1225                 1230             


Asp Arg  Ser Ala Pro Asn Trp  Asn Thr Thr Gly Glu  Val Val Val 
    1235                 1240                 1245             


Ser Met  Glu Pro Glu Glu Pro  Val Lys Lys Leu Glu  Thr Met Val 
    1250                 1255                 1260             


Lys Leu  Asp Ala Thr Ser Asp  Ala Val Val Lys Val  Asp Val Ala 
    1265                 1270                 1275             


Glu Asp  Glu Lys Glu Arg Lys  Lys Lys Lys Lys Lys  Gly Pro Ser 
    1280                 1285                 1290             


Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu Ser Met  Leu Asp Trp 
    1295                 1300                 1305             


Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr Met Lys  Glu Gln Leu 
    1310                 1315                 1320             


Arg Gln  His Glu Thr Ser Gly  Thr Asp Leu Glu Glu  Lys Glu Glu 
    1325                 1330                 1335             


Met Glu  Ser Ala Glu Gly Leu  Lys Gly Pro Met Lys  Ser Lys Glu 
    1340                 1345                 1350             


Lys Ser  Arg Ala Ala Lys Glu  Glu Lys Lys Lys Lys  Asn Gln Ser 
    1355                 1360                 1365             


Pro Gly  Pro Gly Gln Gly Ser  Glu Ala Pro Glu Lys  Lys Lys Ala 
    1370                 1375                 1380             


Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys Glu Leu  Glu Ser Glu 
    1385                 1390                 1395             


Phe Asp  Ser Phe Glu Asp Trp  Leu His Thr Phe Asn  Leu Leu Arg 
    1400                 1405                 1410             


Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser Thr Glu  Glu Glu Arg 
    1415                 1420                 1425             


Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys Val Tyr  Lys Val Pro 
    1430                 1435                 1440             


Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly Tyr Asp  Pro Thr Tyr 
    1445                 1450                 1455             


Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp Pro Ile  Asn Val Leu 
    1460                 1465                 1470             


Val Arg  Ile Tyr Val Val Arg  Ala Thr Asp Leu His  Pro Ala Asp 
    1475                 1480                 1485             


Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala Ile Lys  Leu Gly Lys 
    1490                 1495                 1500             


Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile Ser Lys  Gln Leu Asn 
    1505                 1510                 1515             


Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu Ala Ser  Phe Pro Met 
    1520                 1525                 1530             


Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp Trp Asp  Leu Val Gly 
    1535                 1540                 1545             


Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile Asp Leu  Glu Asn Arg 
    1550                 1555                 1560             


Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly Ile Ala  Gln Thr Tyr 
    1565                 1570                 1575             


Ser Ile  His Gly Tyr Asn Ile  Trp Arg Asp Pro Met  Lys Pro Ser 
    1580                 1585                 1590             


Gln Ile  Leu Thr Arg Leu Cys  Lys Glu Gly Lys Val  Asp Gly Pro 
    1595                 1600                 1605             


His Phe  Gly Pro His Gly Arg  Val Arg Val Ala Asn  Arg Val Phe 
    1610                 1615                 1620             


Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn Gly Gln  Arg Lys Pro 
    1625                 1630                 1635             


Thr Asp  Glu His Val Ala Leu  Ser Ala Leu Arg His  Trp Glu Asp 
    1640                 1645                 1650             


Ile Pro  Arg Val Gly Cys Arg  Leu Val Pro Glu His  Val Glu Thr 
    1655                 1660                 1665             


Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly Ile Glu  Gln Gly Arg 
    1670                 1675                 1680             


Leu Glu  Leu Trp Val Asp Met  Phe Pro Met Asp Met  Pro Ala Pro 
    1685                 1690                 1695             


Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys Pro Lys  Lys Tyr Glu 
    1700                 1705                 1710             


Leu Arg  Val Ile Val Trp Asn  Thr Asp Glu Val Val  Leu Glu Asp 
    1715                 1720                 1725             


Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser Asp Ile  Phe Val Arg 
    1730                 1735                 1740             


Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys Gln Asp  Thr Asp Val 
    1745                 1750                 1755             


His Tyr  His Ser Leu Thr Gly  Glu Gly Asn Phe Asn  Trp Arg Tyr 
    1760                 1765                 1770             


Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu Glu Lys  Ile Val Met 
    1775                 1780                 1785             


Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp Glu Thr  Glu Tyr Lys 
    1790                 1795                 1800             


Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp Asp Ala  Asp His Phe 
    1805                 1810                 1815             


Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu Leu Asp  Leu Asn Arg 
    1820                 1825                 1830             


Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln Cys Thr  Met Glu Met 
    1835                 1840                 1845             


Ala Thr  Gly Glu Val Asp Val  Pro Leu Val Ser Ile  Phe Lys Gln 
    1850                 1855                 1860             


Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu Ala Arg  Asn Glu Asn 
    1865                 1870                 1875             


Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu Ala Glu  Leu His Leu 
    1880                 1885                 1890             


Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro Val Gly  Leu Ala Arg 
    1895                 1900                 1905             


Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn Arg Pro  Asp Thr Ala 
    1910                 1915                 1920             


Phe Val  Trp Phe Leu Asn Pro  Leu Lys Ser Ile Lys  Tyr Leu Ile 
    1925                 1930                 1935             


Cys Thr  Arg Tyr Lys Trp Leu  Ile Ile Lys Ile Val  Leu Ala Leu 
    1940                 1945                 1950             


Leu Gly  Leu Leu Met Leu Ala  Leu Phe Leu Tyr Ser  Leu Pro Gly 
    1955                 1960                 1965             


Tyr Met  Val Lys Lys Leu Leu  Gly Ala 
    1970                 1975         


<210>  10
<211>  7171
<212>  DNA
<213>  Homo sapiens

<400>  10
atcggagggg ggtcgggagg aggaggagga ggcagcggca gagaagagag aggcgtgtga       60

gccgtgctcc accggctagc tccttcccgc tgctcctgcc tggcagtgcc aggcagccca      120

caccagcatg gccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga      180

ccggatcgcc aaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg      240

tgaggatgtg gctgactttg atgagacatt tcggtggccg gtggccagca gcatcgacag      300

aaatgagatg ctggagattc aggttttcaa ctacagcaaa gtcttcagca acaagctcat      360

cgggaccttc cgcatggtgc tgcagaaggt ggtagaggag agccatgtgg aggtgactga      420

cacgctgatt gatgacaaca atgctatcat caagaccagc ctgtgcgtgg aggtccggta      480

tcaggccact gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtc      540

tcttcaagag gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc      600

cagctcccgg cccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc      660

catgaagctc ggcaaaaacc ggtctcacaa ggaggagccc caaagaccag atgaaccggc      720

ggtgctggag atggaagacc ttgaccatct ggccattcgg ctaggagatg gactggatcc      780

cgactcggtg tctctagcct cagtcacagc tctcaccact aatgtctcca acaagcgatc      840

taagccagac attaagatgg agccaagtgc tgggcggccc atggattacc aggtcagcat      900

cacggtgatc gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcgtgga      960

ggtgggtgac gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa     1020

cgagtacttc gtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa     1080

gatttcggtg attcactcca agaacctgct gcgcagtggc accctggtgg gctccttcaa     1140

aatggacgtg ggaaccgtgt actcgcagcc agagcaccag ttccatcaca agtgggccat     1200

cctgtctgac cccgatgaca tctcctcggg gctgaagggc tacgtgaagt gtgacgttgc     1260

cgtggtgggc aaaggggaca acatcaagac gccccacaag gccaatgaga ccgacgaaga     1320

tgacattgag gggaacttgc tgctccccga gggggtgccc cccgaacgcc agtgggcccg     1380

gttctatgtg aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggc     1440

caatgtaaag aaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt     1500

cttctttgct ggccagaagg gcaagacttc agtgcagaag agcagctatg agcccctgtg     1560

gaatgagcag gtcgtcttta cagacctctt ccccccactc tgcaaacgca tgaaggtgca     1620

gatccgagac tcggacaagg tcaacgacgt ggccatcggc acccacttca ttgacctgcg     1680

caagatttct aatgacggag acaaaggctt cctgcccaca ctgggcccag cctgggtgaa     1740

catgtacggc tccacacgta actacacgct gctggatgag catcaggacc tgaacgaggg     1800

cctgggggag ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgt     1860

agacacctcc aaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc     1920

catctcggag agctgtgcag gtaaaatgga agaattcttt ctctttggag ccttcctgga     1980

ggcctcaatg atcgaccgga gaaacggaga caagcccatc acctttgagg tcaccatagg     2040

caactatggg aacgaagttg atggcctgtc ccggccccag cggcctcggc cccggaagga     2100

gccgggggat gaggaagaag tagacctgat tcagaacgca agtgatgacg aggccggtga     2160

tgccggggac ctggcctcag tctcctccac tccaccaatg cggccccagg tcaccgacag     2220

gaactacttc catctgccct acctggagcg aaagccctgc atctacatca agagctggtg     2280

gccggaccag cgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct     2340

ggaagaaggc ctgaacgaca tacaggagat gatcaaaacg gagaagtcct accctgagcg     2400

tcgcctgcgg ggcgtcctgg aggagctgag ctgtggctgc tgccgcttcc tctccctcgc     2460

tgacaaggac cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctg     2520

catgagggag ctggaaaaca tggggcagca ggccaggatg ctgcgggccc aggtgaagcg     2580

gcacacggtg cgggacaagc tgaggctgtg ccagaacttc ctgcagaagc tgcgcttcct     2640

ggcggacgag ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaa     2700

gcgtgtcgcc tatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga     2760

gactggcaag gactgcgcca aggtcaagac gctcttcctt aagctgccag ggaagcgggg     2820

cttcggctcg gcaggctgga cagtgcaggc caaggtggag ctgtacctgt ggctgggcct     2880

cagcaaacag cgcaaggagt tcctgtgcgg cctgccctgt ggcttccagg aggtcaaggc     2940

agcccagggc ctgggcctgc atgccttccc acccgtcagc ctggtctaca ccaagaagca     3000

ggcgttccag ctccgagcgc acatgtacca ggcccgcagc ctctttgccg ccgacagcag     3060

cggactctca gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggt     3120

gctgaatgag accctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct     3180

ctatggtgaa gctcatgagc tgagggacga tccgcccatc attgtcattg aaatctatga     3240

ccaggattcc atgggcaaag ctgacttcat gggccggacc ttcgccaaac ccctggtgaa     3300

gatggcagac gaggcgtact gcccaccccg cttcccacct cagctcgagt actaccagat     3360

ctaccgtggc aacgccacag ctggagacct gctggcggcc ttcgagctgc tgcagattgg     3420

accagcaggg aaggctgacc tgccccccat caatggcccg gtggacgtgg accgaggtcc     3480

catcatgccc gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgct     3540

gttctggggc ctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt     3600

ggacatcgag tgtgcaggga agggggtgca gtcgtccctg atccacaatt ataagaagaa     3660

ccccaacttc aacaccctcg tcaagtggtt tgaagtggac ctcccagaga acgagctgct     3720

gcacccgccc ttgaacatcc gtgtggtgga ctgccgggcc ttcggtcgct acacactggt     3780

gggctcccat gccgtcagct ccctgcgacg cttcatctac cggcccccag accgctcggc     3840

ccccagctgg aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgt gcaatggggg     3900

ctcctcctct cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaa     3960

gaaactggag accatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt     4020

ggctgaggag gagaaggaga agaagaagaa gaagaagggc actgcggagg agccagagga     4080

ggaggagcca gacgagagca tgctggactg gtggtccaag tactttgcct ccattgacac     4140

catgaaggag caacttcgac aacaagagcc ctctggaatt gacttggagg agaaggagga     4200

agtggacaat accgagggcc tgaaggggtc aatgaagggc aaggagaagg caagggctgc     4260

caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccc     4320

cgagaagaag aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccga     4380

gtttgataac tttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga     4440

tgatgaggat ggctccaccg aggaggagcg cattgtggga cgcttcaagg gctccctctg     4500

cgtgtacaaa gtgccactcc cagaggacgt gtcccgggaa gccggctacg actccaccta     4560

cggcatgttc cagggcatcc cgagcaatga ccccatcaat gtgctggtcc gagtctatgt     4620

ggtccgggcc acggacctgc accctgctga catcaacggc aaagctgacc cctacatcgc     4680

catccggcta ggcaagactg acatccgcga caaggagaac tacatctcca agcagctcaa     4740

ccctgtcttt gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgac     4800

ggtggctgtg tatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat     4860

cgacctggag aaccgcttct acagcaagca ccgcgccacc tgcggcatcg cccagaccta     4920

ctccacacat ggctacaata tctggcggga ccccatgaag cccagccaga tcctgacccg     4980

cctctgcaaa gacggcaaag tggacggccc ccactttggg ccccctggga gagtgaaggt     5040

ggccaaccgc gtcttcactg ggccctctga gattgaggac gagaacggtc agaggaagcc     5100

cacagacgag catgtggcgc tgttggccct gaggcactgg gaggacatcc cccgcgcagg     5160

ctgccgcctg gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccggg     5220

catcgagcag ggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc     5280

tgggacgcct ctggacatct cacctcggaa gcccaagaag tacgagctgc gggtcatcat     5340

ctggaacaca gatgaggtgg tcttggagga cgacgacttc ttcacagggg agaagtccag     5400

tgacatcttc gtgagggggt ggctgaaggg ccagcaggag gacaagcagg acacagacgt     5460

ccactaccac tccctcactg gcgagggcaa cttcaactgg cgctacctgt tccccttcga     5520

ctacctggcg gcggaggaga agatcgtcat ctccaagaag gagtccatgt tctcctggga     5580

cgagaccgag tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccactt     5640

ctccgctgac gacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc     5700

aaagacagcc aagcagtgca ccatggagat ggccaccggg gaggtggacg tgcccctcgt     5760

gtccatcttc aagcaaaagc gcgtcaaagg ctggtggccc ctcctggccc gcaatgagaa     5820

cgatgagttt gagctcacgg gcaaggtgga ggctgagctg catttactga cagcagagga     5880

ggcagagaag aacccagtgg gcctggcccg caatgaacct gaccccctag agaaacccaa     5940

ccggcccgac acgagcttca tctggttcct gaaccctctc aagtcggctc gctacttctt     6000

gtggcacacg tatcgctggc tgctcctcaa actgttgctg ctcctgctgc tgctcctcct     6060

cctcgccctg ttcctctact ctgtgcctgg ctacctggtc aagaaaatcc tcggggcctg     6120

agcccagtgg cctcctggcc ggcccgacac ggccttcgtc tggttcctca accctctcaa     6180

gtccatcaag tacctcatct gcacccggta caagtggctc atcatcaaga tcgtgctggc     6240

gctgttgggg ctgctcatgt tggggctctt cctctacagc ctccctggct acatggtcaa     6300

aaagctcctt ggggcatgaa ggccgccagc tcccgccagc cgctccccag ccctgccgca     6360

tttcctttca gtggcttgga ctctttccca tctcccctgg ggagcctgag gagcccagcg     6420

tccactcttc atgccttggg ccgagcctgc ctcctgcttg cgggggccgc ctgtcctcac     6480

tgccccaggc tgcggcttgc ccagtcccgc ccctctgacc cctgcctgtg ggctggggag     6540

ccttggatgg ggtggggacc tggaatgggt ctctcttgcc ccacctggct gaggcgccac     6600

ccttcttcag gcccaggctc cagaggaaga ctcctgaaac cctccccagg tcttccaagt     6660

acaggattga agctttagtg aaattaacca aggaccatgg gtcagtgccc agggctttaa     6720

aaagaatgaa cgagcaaaag gtatccccgc cgtgacccct gcagatagca ccggtctttg     6780

atccgcagca ggggccagac cctgcccaca agtcccagcg cggctgcttc tgccactgct     6840

gggctccact tggctcctct cacttcccag ggggtcgcct gtcctgcctg tgggtttcca     6900

tggcttccca gagctccctc tgccccagcc agcgcctcca ggcccagctg aggagctgtg     6960

agaagcagca gaggggactc cccatcccgg gcacaccctg tcctcccacc cctgccccct     7020

tgcccttcca gccctttcag ctgcagctgg gagctggccc gtcaagtgct gcccctgcct     7080

gtgtctgggt ttctgttggc tgtttttctt ttcttgagtg gtgatttttc tctaaataaa     7140

agaagtcaag cactgaaaaa aaaaaaaaaa a                                    7171


<210>  11
<211>  4969
<212>  DNA
<213>  Homo sapiens

<400>  11
ccgtgagttc tgcccaggcc ctgtgagctc accagagcca cagactcaca gcccagaggt       60

ggcttcttcc ttcaggaact gaagaacccc catgaacacc aacatctcca ggttctgaga      120

acagaacctg ggaaattgat gacttcctca tgatgaccga tactcaggat ggccctagcg      180

agagctccca gatcatgagg aagaaggcct gaacgacata caggagatga tcaaaacgga      240

gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagct gtggctgctg      300

ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcacca ggcttgaccg      360

ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgct      420

gcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct      480

gcagaagctg cgcttcctgg cggacgagcc ccagcacagc attcccgaca tcttcatctg      540

gatgatgagc aacaacaagc gtgtcgccta tgcccgtgtg ccctccaagg acctgctctt      600

ctccatcgtg gaggaggaga ctggcaagga ctgcgccaag gtcaagacgc tcttccttaa      660

gctgccaggg aagcggggct tcggctcggc aggctggaca gtgcaggcca aggtggagct      720

gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcc tgccctgtgg      780

cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcct      840

ggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct      900

ctttgccgcc gacagcagcg gactctcaga cccctttgcc cgcgtcttct tcatcaatca      960

gagtcagtgc acagaggtgc tgaatgagac cctgtgtccc acctgggacc agatgctggt     1020

gttcgacaac ctggagctct atggtgaagc tcatgagctg agggacgatc cgcccatcat     1080

tgtcattgaa atctatgacc aggattccat gggcaaagct gacttcatgg gccggacctt     1140

cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgct tcccacctca     1200

gctcgagtac taccagatct accgtggcaa cgccacagct ggagacctgc tggcggcctt     1260

cgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt     1320

ggacgtggac cgaggtccca tcatgcccgt gcccatgggc atccggcccg tgctcagcaa     1380

gtaccgagtg gaggtgctgt tctggggcct acgggaccta aagcgggtga acctggccca     1440

ggtggaccgg ccacgggtgg acatcgagtg tgcagggaag ggggtgcagt cgtccctgat     1500

ccacaattat aagaagaacc ccaacttcaa caccctcgtc aagtggtttg aagtggacct     1560

cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggact gccgggcctt     1620

cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccg     1680

gcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga     1740

gccagaggta cccatcaaga aactggagac catggtgaag ctggacgcga cttctgaagc     1800

tgttgtcaag gtggatgtgg ctgaggagga gaaggagaag aagaagaaga agaagggcac     1860

tgcggaggag ccagaggagg aggagccaga cgagagcatg ctggactggt ggtccaagta     1920

ctttgcctcc attgacacca tgaaggagca acttcgacaa caagagccct ctggaattga     1980

cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaa tgaagggcaa     2040

ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctgg     2100

ccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc     2160

caaagagctg gagtccgagt ttgataactt tgaggactgg ctgcacactt tcaacttgct     2220

tcggggcaag accggggatg atgaggatgg ctccaccgag gaggagcgca ttgtgggacg     2280

cttcaagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgt cccgggaagc     2340

cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgacc ccatcaatgt     2400

gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgaca tcaacggcaa     2460

agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaacta     2520

catctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc     2580

catggaatcc atgctgacgg tggctgtgta tgactgggac ctggtgggca ctgatgacct     2640

cattggggaa accaagatcg acctggagaa ccgcttctac agcaagcacc gcgccacctg     2700

cggcatcgcc cagacctact ccacacatgg ctacaatatc tggcgggacc ccatgaagcc     2760

cagccagatc ctgacccgcc tctgcaaaga cggcaaagtg gacggccccc actttgggcc     2820

ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgaga ttgaggacga     2880

gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactggga     2940

ggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct     3000

caaccccgac aagccgggca tcgagcaggg ccgcctggag ctgtgggtgg acatgttccc     3060

catggacatg ccagcccctg ggacgcctct ggacatctca cctcggaagc ccaagaagta     3120

cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacg acgacttctt     3180

cacaggggag aagtccagtg acatcttcgt gagggggtgg ctgaagggcc agcaggagga     3240

caagcaggac acagacgtcc actaccactc cctcactggc gagggcaact tcaactggcg     3300

ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaagga     3360

gtccatgttc tcctgggacg agaccgagta caagatcccc gcgcggctca ccctgcagat     3420

ctgggatgcg gaccacttct ccgctgacga cttcctgggg gccatcgagc tggacctgaa     3480

ccggttcccg cggggcgcaa agacagccaa gcagtgcacc atggagatgg ccaccgggga     3540

ggtggacgtg cccctcgtgt ccatcttcaa gcaaaagcgc gtcaaaggct ggtggcccct     3600

cctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggagg ctgagctgca     3660

tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgca atgaacctga     3720

ccccctagag aaacccaacc ggcccgacac gagcttcatc tggttcctga accctctcaa     3780

gtcggctcgc tacttcttgt ggcacacgta tcgctggctg ctcctcaaac tgttgctgct     3840

cctgctgctg ctcctcctcc tcgccctgtt cctctactct gtgcctggct acctggtcaa     3900

gaaaatcctc ggggcctgag cccagtggcc tcctggccgg cccgacacgg ccttcgtctg     3960

gttcctcaac cctctcaagt ccatcaagta cctcatctgc acccggtaca agtggctcat     4020

catcaagatc gtgctggcgc tgttggggct gctcatgttg gggctcttcc tctacagcct     4080

ccctggctac atggtcaaaa agctccttgg ggcatgaagg ccgccagctc ccgccagccg     4140

ctccccagcc ctgccgcatt tcctttcagt ggcttggact ctttcccatc tcccctgggg     4200

agcctgagga gcccagcgtc cactcttcat gccttgggcc gagcctgcct cctgcttgcg     4260

ggggccgcct gtcctcactg ccccaggctg cggcttgccc agtcccgccc ctctgacccc     4320

tgcctgtggg ctggggagcc ttggatgggg tggggacctg gaatgggtct ctcttgcccc     4380

acctggctga ggcgccaccc ttcttcaggc ccaggctcca gaggaagact cctgaaaccc     4440

tccccaggtc ttccaagtac aggattgaag ctttagtgaa attaaccaag gaccatgggt     4500

cagtgcccag ggctttaaaa agaatgaacg agcaaaaggt atccccgccg tgacccctgc     4560

agatagcacc ggtctttgat ccgcagcagg ggccagaccc tgcccacaag tcccagcgcg     4620

gctgcttctg ccactgctgg gctccacttg gctcctctca cttcccaggg ggtcgcctgt     4680

cctgcctgtg ggtttccatg gcttcccaga gctccctctg ccccagccag cgcctccagg     4740

cccagctgag gagctgtgag aagcagcaga ggggactccc catcccgggc acaccctgtc     4800

ctcccacccc tgcccccttg cccttccagc cctttcagct gcagctggga gctggcccgt     4860

caagtgctgc ccctgcctgt gtctgggttt ctgttggctg tttttctttt cttgagtggt     4920

gatttttctc taaataaaag aagtcaagca ctgaaaaaaa aaaaaaaaa                 4969


<210>  12
<211>  4771
<212>  DNA
<213>  Homo sapiens

<400>  12
ccgtgagttc tgcccaggcc ctgtgagctc accagagcca cagactcaca gcccagaggt       60

ggcttcttcc ttcaggaact gaagaacccc catgaacacc aacatctcca ggttctgaga      120

acagaacctg ggaaattgat gacttcctca tgatgaccga tactcaggat ggccctagcg      180

agagctccca gatcatgagg aagaaggcct gaacgacata caggagatga tcaaaacgga      240

gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagct gtggctgctg      300

ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcacca ggcttgaccg      360

ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgct      420

gcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct      480

gcagaagctg cgcttcctgg cggacgagcc ccagcacagc attcccgaca tcttcatctg      540

gatgatgagc aacaacaagc gtgtcgccta tgcccgtgtg ccctccaagg acctgctctt      600

ctccatcgtg gaggaggaga ctggcaagga ctgcgccaag gtcaagacgc tcttccttaa      660

gctgccaggg aagcggggct tcggctcggc aggctggaca gtgcaggcca aggtggagct      720

gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcc tgccctgtgg      780

cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcct      840

ggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct      900

ctttgccgcc gacagcagcg gactctcaga cccctttgcc cgcgtcttct tcatcaatca      960

gagtcagtgc acagaggtgc tgaatgagac cctgtgtccc acctgggacc agatgctggt     1020

gttcgacaac ctggagctct atggtgaagc tcatgagctg agggacgatc cgcccatcat     1080

tgtcattgaa atctatgacc aggattccat gggcaaagct gacttcatgg gccggacctt     1140

cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgct tcccacctca     1200

gctcgagtac taccagatct accgtggcaa cgccacagct ggagacctgc tggcggcctt     1260

cgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt     1320

ggacgtggac cgaggtccca tcatgcccgt gcccatgggc atccggcccg tgctcagcaa     1380

gtaccgagtg gaggtgctgt tctggggcct acgggaccta aagcgggtga acctggccca     1440

ggtggaccgg ccacgggtgg acatcgagtg tgcagggaag ggggtgcagt cgtccctgat     1500

ccacaattat aagaagaacc ccaacttcaa caccctcgtc aagtggtttg aagtggacct     1560

cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggact gccgggcctt     1620

cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccg     1680

gcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga     1740

gccagaggta cccatcaaga aactggagac catggtgaag ctggacgcga cttctgaagc     1800

tgttgtcaag gtggatgtgg ctgaggagga gaaggagaag aagaagaaga agaagggcac     1860

tgcggaggag ccagaggagg aggagccaga cgagagcatg ctggactggt ggtccaagta     1920

ctttgcctcc attgacacca tgaaggagca acttcgacaa caagagccct ctggaattga     1980

cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaa tgaagggcaa     2040

ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctgg     2100

ccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc     2160

caaagagctg gagtccgagt ttgataactt tgaggactgg ctgcacactt tcaacttgct     2220

tcggggcaag accggggatg atgaggatgg ctccaccgag gaggagcgca ttgtgggacg     2280

cttcaagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgt cccgggaagc     2340

cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgacc ccatcaatgt     2400

gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgaca tcaacggcaa     2460

agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaacta     2520

catctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc     2580

catggaatcc atgctgacgg tggctgtgta tgactgggac ctggtgggca ctgatgacct     2640

cattggggaa accaagatcg acctggagaa ccgcttctac agcaagcacc gcgccacctg     2700

cggcatcgcc cagacctact ccacacatgg ctacaatatc tggcgggacc ccatgaagcc     2760

cagccagatc ctgacccgcc tctgcaaaga cggcaaagtg gacggccccc actttgggcc     2820

ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgaga ttgaggacga     2880

gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactggga     2940

ggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct     3000

caaccccgac aagccgggca tcgagcaggg ccgcctggag ctgtgggtgg acatgttccc     3060

catggacatg ccagcccctg ggacgcctct ggacatctca cctcggaagc ccaagaagta     3120

cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacg acgacttctt     3180

cacaggggag aagtccagtg acatcttcgt gagggggtgg ctgaagggcc agcaggagga     3240

caagcaggac acagacgtcc actaccactc cctcactggc gagggcaact tcaactggcg     3300

ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaagga     3360

gtccatgttc tcctgggacg agaccgagta caagatcccc gcgcggctca ccctgcagat     3420

ctgggatgcg gaccacttct ccgctgacga cttcctgggg gccatcgagc tggacctgaa     3480

ccggttcccg cggggcgcaa agacagccaa gcagtgcacc atggagatgg ccaccgggga     3540

ggtggacgtg cccctcgtgt ccatcttcaa gcaaaagcgc gtcaaaggct ggtggcccct     3600

cctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggagg ctgagctgca     3660

tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgca atgaacctga     3720

ccccctagag aaacccaacc ggcccgacac ggccttcgtc tggttcctca accctctcaa     3780

gtccatcaag tacctcatct gcacccggta caagtggctc atcatcaaga tcgtgctggc     3840

gctgttgggg ctgctcatgt tggggctctt cctctacagc ctccctggct acatggtcaa     3900

aaagctcctt ggggcatgaa ggccgccagc tcccgccagc cgctccccag ccctgccgca     3960

tttcctttca gtggcttgga ctctttccca tctcccctgg ggagcctgag gagcccagcg     4020

tccactcttc atgccttggg ccgagcctgc ctcctgcttg cgggggccgc ctgtcctcac     4080

tgccccaggc tgcggcttgc ccagtcccgc ccctctgacc cctgcctgtg ggctggggag     4140

ccttggatgg ggtggggacc tggaatgggt ctctcttgcc ccacctggct gaggcgccac     4200

ccttcttcag gcccaggctc cagaggaaga ctcctgaaac cctccccagg tcttccaagt     4260

acaggattga agctttagtg aaattaacca aggaccatgg gtcagtgccc agggctttaa     4320

aaagaatgaa cgagcaaaag gtatccccgc cgtgacccct gcagatagca ccggtctttg     4380

atccgcagca ggggccagac cctgcccaca agtcccagcg cggctgcttc tgccactgct     4440

gggctccact tggctcctct cacttcccag ggggtcgcct gtcctgcctg tgggtttcca     4500

tggcttccca gagctccctc tgccccagcc agcgcctcca ggcccagctg aggagctgtg     4560

agaagcagca gaggggactc cccatcccgg gcacaccctg tcctcccacc cctgccccct     4620

tgcccttcca gccctttcag ctgcagctgg gagctggccc gtcaagtgct gcccctgcct     4680

gtgtctgggt ttctgttggc tgtttttctt ttcttgagtg gtgatttttc tctaaataaa     4740

agaagtcaag cactgaaaaa aaaaaaaaaa a                                    4771


<210>  13
<211>  5123
<212>  DNA
<213>  Homo sapiens

<400>  13
ccgtgagttc tgcccaggcc ctgtgagctc accagagcca cagactcaca gcccagaggt       60

ggcttcttcc ttcaggaact gaagaacccc catgaacacc aacatctcca ggttctgaga      120

acagaacctg ggaaattgat gacttcctca tgatgaccga tactcaggat ggccctagcg      180

agagctccca gatcatgagg tccctcactc ccctgatcaa cagggaggag gcatttgggg      240

aggctgggga ggcggggctg tggcccagca tcacccacac tcctgattca caggaagaag      300

gcctgaacga catacaggag atgatcaaaa cggagaagtc ctaccctgag cgtcgcctgc      360

ggggcgtcct ggaggagctg agctgtggct gctgccgctt cctctccctc gctgacaagg      420

accagggcca ctcatcccgc accaggcttg accgggagcg cctcaagtcc tgcatgaggg      480

agctggaaaa catggggcag caggccagga tgctgcgggc ccaggtgaag cggcacacgg      540

tgcgggacaa gctgaggctg tgccagaact tcctgcagaa gctgcgcttc ctggcggacg      600

agccccagca cagcattccc gacatcttca tctggatgat gagcaacaac aagcgtgtcg      660

cctatgcccg tgtgccctcc aaggacctgc tcttctccat cgtggaggag gagactggca      720

aggactgcgc caaggtcaag acgctcttcc ttaagctgcc agggaagcgg ggcttcggct      780

cggcaggctg gacagtgcag gccaaggtgg agctgtacct gtggctgggc ctcagcaaac      840

agcgcaagga gttcctgtgc ggcctgccct gtggcttcca ggaggtcaag gcagcccagg      900

gcctgggcct gcatgccttc ccacccgtca gcctggtcta caccaagaag caggcgttcc      960

agctccgagc gcacatgtac caggcccgca gcctctttgc cgccgacagc agcggactct     1020

cagacccctt tgcccgcgtc ttcttcatca atcagagtca gtgcacagag gtgctgaatg     1080

agaccctgtg tcccacctgg gaccagatgc tggtgttcga caacctggag ctctatggtg     1140

aagctcatga gctgagggac gatccgccca tcattgtcat tgaaatctat gaccaggatt     1200

ccatgggcaa agctgacttc atgggccgga ccttcgccaa acccctggtg aagatggcag     1260

acgaggcgta ctgcccaccc cgcttcccac ctcagctcga gtactaccag atctaccgtg     1320

gcaacgccac agctggagac ctgctggcgg ccttcgagct gctgcagatt ggaccagcag     1380

ggaaggctga cctgcccccc atcaatggcc cggtggacgt ggaccgaggt cccatcatgc     1440

ccgtgcccat gggcatccgg cccgtgctca gcaagtaccg agtggaggtg ctgttctggg     1500

gcctacggga cctaaagcgg gtgaacctgg cccaggtgga ccggccacgg gtggacatcg     1560

agtgtgcagg gaagggggtg cagtcgtccc tgatccacaa ttataagaag aaccccaact     1620

tcaacaccct cgtcaagtgg tttgaagtgg acctcccaga gaacgagctg ctgcacccgc     1680

ccttgaacat ccgtgtggtg gactgccggg ccttcggtcg ctacacactg gtgggctccc     1740

atgccgtcag ctccctgcga cgcttcatct accggccccc agaccgctcg gcccccagct     1800

ggaacaccac ggtcaggctt ctccggcgct gccgtgtgct gtgcaatggg ggctcctcct     1860

ctcactccac aggggaggtt gtggtgacta tggagccaga ggtacccatc aagaaactgg     1920

agaccatggt gaagctggac gcgacttctg aagctgttgt caaggtggat gtggctgagg     1980

aggagaagga gaagaagaag aagaagaagg gcactgcgga ggagccagag gaggaggagc     2040

cagacgagag catgctggac tggtggtcca agtactttgc ctccattgac accatgaagg     2100

agcaacttcg acaacaagag ccctctggaa ttgacttgga ggagaaggag gaagtggaca     2160

ataccgaggg cctgaagggg tcaatgaagg gcaaggagaa ggcaagggct gccaaagagg     2220

agaagaagaa gaaaactcag agctctggct ctggccaggg gtccgaggcc cccgagaaga     2280

agaaacccaa gattgatgag cttaaggtat accccaaaga gctggagtcc gagtttgata     2340

actttgagga ctggctgcac actttcaact tgcttcgggg caagaccggg gatgatgagg     2400

atggctccac cgaggaggag cgcattgtgg gacgcttcaa gggctccctc tgcgtgtaca     2460

aagtgccact cccagaggac gtgtcccggg aagccggcta cgactccacc tacggcatgt     2520

tccagggcat cccgagcaat gaccccatca atgtgctggt ccgagtctat gtggtccggg     2580

ccacggacct gcaccctgct gacatcaacg gcaaagctga cccctacatc gccatccggc     2640

taggcaagac tgacatccgc gacaaggaga actacatctc caagcagctc aaccctgtct     2700

ttgggaagtc ctttgacatc gaggcctcct tccccatgga atccatgctg acggtggctg     2760

tgtatgactg ggacctggtg ggcactgatg acctcattgg ggaaaccaag atcgacctgg     2820

agaaccgctt ctacagcaag caccgcgcca cctgcggcat cgcccagacc tactccacac     2880

atggctacaa tatctggcgg gaccccatga agcccagcca gatcctgacc cgcctctgca     2940

aagacggcaa agtggacggc ccccactttg ggccccctgg gagagtgaag gtggccaacc     3000

gcgtcttcac tgggccctct gagattgagg acgagaacgg tcagaggaag cccacagacg     3060

agcatgtggc gctgttggcc ctgaggcact gggaggacat cccccgcgca ggctgccgcc     3120

tggtgccaga gcatgtggag acgaggccgc tgctcaaccc cgacaagccg ggcatcgagc     3180

agggccgcct ggagctgtgg gtggacatgt tccccatgga catgccagcc cctgggacgc     3240

ctctggacat ctcacctcgg aagcccaaga agtacgagct gcgggtcatc atctggaaca     3300

cagatgaggt ggtcttggag gacgacgact tcttcacagg ggagaagtcc agtgacatct     3360

tcgtgagggg gtggctgaag ggccagcagg aggacaagca ggacacagac gtccactacc     3420

actccctcac tggcgagggc aacttcaact ggcgctacct gttccccttc gactacctgg     3480

cggcggagga gaagatcgtc atctccaaga aggagtccat gttctcctgg gacgagaccg     3540

agtacaagat ccccgcgcgg ctcaccctgc agatctggga tgcggaccac ttctccgctg     3600

acgacttcct gggggccatc gagctggacc tgaaccggtt cccgcggggc gcaaagacag     3660

ccaagcagtg caccatggag atggccaccg gggaggtgga cgtgcccctc gtgtccatct     3720

tcaagcaaaa gcgcgtcaaa ggctggtggc ccctcctggc ccgcaatgag aacgatgagt     3780

ttgagctcac gggcaaggtg gaggctgagc tgcatttact gacagcagag gaggcagaga     3840

agaacccagt gggcctggcc cgcaatgaac ctgaccccct agagaaaccc aaccggcccg     3900

acacgagctt catctggttc ctgaaccctc tcaagtcggc tcgctacttc ttgtggcaca     3960

cgtatcgctg gctgctcctc aaactgttgc tgctcctgct gctgctcctc ctcctcgccc     4020

tgttcctcta ctctgtgcct ggctacctgg tcaagaaaat cctcggggcc tgagcccagt     4080

ggcctcctgg ccggcccgac acggccttcg tctggttcct caaccctctc aagtccatca     4140

agtacctcat ctgcacccgg tacaagtggc tcatcatcaa gatcgtgctg gcgctgttgg     4200

ggctgctcat gttggggctc ttcctctaca gcctccctgg ctacatggtc aaaaagctcc     4260

ttggggcatg aaggccgcca gctcccgcca gccgctcccc agccctgccg catttccttt     4320

cagtggcttg gactctttcc catctcccct ggggagcctg aggagcccag cgtccactct     4380

tcatgccttg ggccgagcct gcctcctgct tgcgggggcc gcctgtcctc actgccccag     4440

gctgcggctt gcccagtccc gcccctctga cccctgcctg tgggctgggg agccttggat     4500

ggggtgggga cctggaatgg gtctctcttg ccccacctgg ctgaggcgcc acccttcttc     4560

aggcccaggc tccagaggaa gactcctgaa accctcccca ggtcttccaa gtacaggatt     4620

gaagctttag tgaaattaac caaggaccat gggtcagtgc ccagggcttt aaaaagaatg     4680

aacgagcaaa aggtatcccc gccgtgaccc ctgcagatag caccggtctt tgatccgcag     4740

caggggccag accctgccca caagtcccag cgcggctgct tctgccactg ctgggctcca     4800

cttggctcct ctcacttccc agggggtcgc ctgtcctgcc tgtgggtttc catggcttcc     4860

cagagctccc tctgccccag ccagcgcctc caggcccagc tgaggagctg tgagaagcag     4920

cagaggggac tccccatccc gggcacaccc tgtcctccca cccctgcccc cttgcccttc     4980

cagccctttc agctgcagct gggagctggc ccgtcaagtg ctgcccctgc ctgtgtctgg     5040

gtttctgttg gctgtttttc ttttcttgag tggtgatttt tctctaaata aaagaagtca     5100

agcactgaaa aaaaaaaaaa aaa                                             5123


<210>  14
<211>  6973
<212>  DNA
<213>  Homo sapiens

<400>  14
atcggagggg ggtcgggagg aggaggagga ggcagcggca gagaagagag aggcgtgtga       60

gccgtgctcc accggctagc tccttcccgc tgctcctgcc tggcagtgcc aggcagccca      120

caccagcatg gccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga      180

ccggatcgcc aaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg      240

tgaggatgtg gctgactttg atgagacatt tcggtggccg gtggccagca gcatcgacag      300

aaatgagatg ctggagattc aggttttcaa ctacagcaaa gtcttcagca acaagctcat      360

cgggaccttc cgcatggtgc tgcagaaggt ggtagaggag agccatgtgg aggtgactga      420

cacgctgatt gatgacaaca atgctatcat caagaccagc ctgtgcgtgg aggtccggta      480

tcaggccact gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtc      540

tcttcaagag gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc      600

cagctcccgg cccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc      660

catgaagctc ggcaaaaacc ggtctcacaa ggaggagccc caaagaccag atgaaccggc      720

ggtgctggag atggaagacc ttgaccatct ggccattcgg ctaggagatg gactggatcc      780

cgactcggtg tctctagcct cagtcacagc tctcaccact aatgtctcca acaagcgatc      840

taagccagac attaagatgg agccaagtgc tgggcggccc atggattacc aggtcagcat      900

cacggtgatc gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcgtgga      960

ggtgggtgac gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa     1020

cgagtacttc gtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa     1080

gatttcggtg attcactcca agaacctgct gcgcagtggc accctggtgg gctccttcaa     1140

aatggacgtg ggaaccgtgt actcgcagcc agagcaccag ttccatcaca agtgggccat     1200

cctgtctgac cccgatgaca tctcctcggg gctgaagggc tacgtgaagt gtgacgttgc     1260

cgtggtgggc aaaggggaca acatcaagac gccccacaag gccaatgaga ccgacgaaga     1320

tgacattgag gggaacttgc tgctccccga gggggtgccc cccgaacgcc agtgggcccg     1380

gttctatgtg aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggc     1440

caatgtaaag aaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt     1500

cttctttgct ggccagaagg gcaagacttc agtgcagaag agcagctatg agcccctgtg     1560

gaatgagcag gtcgtcttta cagacctctt ccccccactc tgcaaacgca tgaaggtgca     1620

gatccgagac tcggacaagg tcaacgacgt ggccatcggc acccacttca ttgacctgcg     1680

caagatttct aatgacggag acaaaggctt cctgcccaca ctgggcccag cctgggtgaa     1740

catgtacggc tccacacgta actacacgct gctggatgag catcaggacc tgaacgaggg     1800

cctgggggag ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgt     1860

agacacctcc aaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc     1920

catctcggag agctgtgcag gtaaaatgga agaattcttt ctctttggag ccttcctgga     1980

ggcctcaatg atcgaccgga gaaacggaga caagcccatc acctttgagg tcaccatagg     2040

caactatggg aacgaagttg atggcctgtc ccggccccag cggcctcggc cccggaagga     2100

gccgggggat gaggaagaag tagacctgat tcagaacgca agtgatgacg aggccggtga     2160

tgccggggac ctggcctcag tctcctccac tccaccaatg cggccccagg tcaccgacag     2220

gaactacttc catctgccct acctggagcg aaagccctgc atctacatca agagctggtg     2280

gccggaccag cgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct     2340

ggaagaaggc ctgaacgaca tacaggagat gatcaaaacg gagaagtcct accctgagcg     2400

tcgcctgcgg ggcgtcctgg aggagctgag ctgtggctgc tgccgcttcc tctccctcgc     2460

tgacaaggac cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctg     2520

catgagggag ctggaaaaca tggggcagca ggccaggatg ctgcgggccc aggtgaagcg     2580

gcacacggtg cgggacaagc tgaggctgtg ccagaacttc ctgcagaagc tgcgcttcct     2640

ggcggacgag ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaa     2700

gcgtgtcgcc tatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga     2760

gactggcaag gactgcgcca aggtcaagac gctcttcctt aagctgccag ggaagcgggg     2820

cttcggctcg gcaggctgga cagtgcaggc caaggtggag ctgtacctgt ggctgggcct     2880

cagcaaacag cgcaaggagt tcctgtgcgg cctgccctgt ggcttccagg aggtcaaggc     2940

agcccagggc ctgggcctgc atgccttccc acccgtcagc ctggtctaca ccaagaagca     3000

ggcgttccag ctccgagcgc acatgtacca ggcccgcagc ctctttgccg ccgacagcag     3060

cggactctca gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggt     3120

gctgaatgag accctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct     3180

ctatggtgaa gctcatgagc tgagggacga tccgcccatc attgtcattg aaatctatga     3240

ccaggattcc atgggcaaag ctgacttcat gggccggacc ttcgccaaac ccctggtgaa     3300

gatggcagac gaggcgtact gcccaccccg cttcccacct cagctcgagt actaccagat     3360

ctaccgtggc aacgccacag ctggagacct gctggcggcc ttcgagctgc tgcagattgg     3420

accagcaggg aaggctgacc tgccccccat caatggcccg gtggacgtgg accgaggtcc     3480

catcatgccc gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgct     3540

gttctggggc ctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt     3600

ggacatcgag tgtgcaggga agggggtgca gtcgtccctg atccacaatt ataagaagaa     3660

ccccaacttc aacaccctcg tcaagtggtt tgaagtggac ctcccagaga acgagctgct     3720

gcacccgccc ttgaacatcc gtgtggtgga ctgccgggcc ttcggtcgct acacactggt     3780

gggctcccat gccgtcagct ccctgcgacg cttcatctac cggcccccag accgctcggc     3840

ccccagctgg aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgt gcaatggggg     3900

ctcctcctct cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaa     3960

gaaactggag accatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt     4020

ggctgaggag gagaaggaga agaagaagaa gaagaagggc actgcggagg agccagagga     4080

ggaggagcca gacgagagca tgctggactg gtggtccaag tactttgcct ccattgacac     4140

catgaaggag caacttcgac aacaagagcc ctctggaatt gacttggagg agaaggagga     4200

agtggacaat accgagggcc tgaaggggtc aatgaagggc aaggagaagg caagggctgc     4260

caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccc     4320

cgagaagaag aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccga     4380

gtttgataac tttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga     4440

tgatgaggat ggctccaccg aggaggagcg cattgtggga cgcttcaagg gctccctctg     4500

cgtgtacaaa gtgccactcc cagaggacgt gtcccgggaa gccggctacg actccaccta     4560

cggcatgttc cagggcatcc cgagcaatga ccccatcaat gtgctggtcc gagtctatgt     4620

ggtccgggcc acggacctgc accctgctga catcaacggc aaagctgacc cctacatcgc     4680

catccggcta ggcaagactg acatccgcga caaggagaac tacatctcca agcagctcaa     4740

ccctgtcttt gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgac     4800

ggtggctgtg tatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat     4860

cgacctggag aaccgcttct acagcaagca ccgcgccacc tgcggcatcg cccagaccta     4920

ctccacacat ggctacaata tctggcggga ccccatgaag cccagccaga tcctgacccg     4980

cctctgcaaa gacggcaaag tggacggccc ccactttggg ccccctggga gagtgaaggt     5040

ggccaaccgc gtcttcactg ggccctctga gattgaggac gagaacggtc agaggaagcc     5100

cacagacgag catgtggcgc tgttggccct gaggcactgg gaggacatcc cccgcgcagg     5160

ctgccgcctg gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccggg     5220

catcgagcag ggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc     5280

tgggacgcct ctggacatct cacctcggaa gcccaagaag tacgagctgc gggtcatcat     5340

ctggaacaca gatgaggtgg tcttggagga cgacgacttc ttcacagggg agaagtccag     5400

tgacatcttc gtgagggggt ggctgaaggg ccagcaggag gacaagcagg acacagacgt     5460

ccactaccac tccctcactg gcgagggcaa cttcaactgg cgctacctgt tccccttcga     5520

ctacctggcg gcggaggaga agatcgtcat ctccaagaag gagtccatgt tctcctggga     5580

cgagaccgag tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccactt     5640

ctccgctgac gacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc     5700

aaagacagcc aagcagtgca ccatggagat ggccaccggg gaggtggacg tgcccctcgt     5760

gtccatcttc aagcaaaagc gcgtcaaagg ctggtggccc ctcctggccc gcaatgagaa     5820

cgatgagttt gagctcacgg gcaaggtgga ggctgagctg catttactga cagcagagga     5880

ggcagagaag aacccagtgg gcctggcccg caatgaacct gaccccctag agaaacccaa     5940

ccggcccgac acggccttcg tctggttcct caaccctctc aagtccatca agtacctcat     6000

ctgcacccgg tacaagtggc tcatcatcaa gatcgtgctg gcgctgttgg ggctgctcat     6060

gttggggctc ttcctctaca gcctccctgg ctacatggtc aaaaagctcc ttggggcatg     6120

aaggccgcca gctcccgcca gccgctcccc agccctgccg catttccttt cagtggcttg     6180

gactctttcc catctcccct ggggagcctg aggagcccag cgtccactct tcatgccttg     6240

ggccgagcct gcctcctgct tgcgggggcc gcctgtcctc actgccccag gctgcggctt     6300

gcccagtccc gcccctctga cccctgcctg tgggctgggg agccttggat ggggtgggga     6360

cctggaatgg gtctctcttg ccccacctgg ctgaggcgcc acccttcttc aggcccaggc     6420

tccagaggaa gactcctgaa accctcccca ggtcttccaa gtacaggatt gaagctttag     6480

tgaaattaac caaggaccat gggtcagtgc ccagggcttt aaaaagaatg aacgagcaaa     6540

aggtatcccc gccgtgaccc ctgcagatag caccggtctt tgatccgcag caggggccag     6600

accctgccca caagtcccag cgcggctgct tctgccactg ctgggctcca cttggctcct     6660

ctcacttccc agggggtcgc ctgtcctgcc tgtgggtttc catggcttcc cagagctccc     6720

tctgccccag ccagcgcctc caggcccagc tgaggagctg tgagaagcag cagaggggac     6780

tccccatccc gggcacaccc tgtcctccca cccctgcccc cttgcccttc cagccctttc     6840

agctgcagct gggagctggc ccgtcaagtg ctgcccctgc ctgtgtctgg gtttctgttg     6900

gctgtttttc ttttcttgag tggtgatttt tctctaaata aaagaagtca agcactgaaa     6960

aaaaaaaaaa aaa                                                        6973


<210>  15
<211>  7125
<212>  DNA
<213>  Mus musculus

<400>  15
ttggttgcct tggtctctgt gggcagcagc aggaggaggc ggcagcagcc agagaagagg       60

gaggcgtgtg agccacactc caccagcgag cttcttcccg ctgctctgga actgcccagg      120

ctctccccac cagcatggcc ctgattgttc acctcaagac tgtctcagag ctccgaggca      180

aaggtgaccg gattgccaaa gtcactttcc gagggcagtc tttctactcc cgggtcctgg      240

agaactgcga gggtgtggct gactttgatg agacgttccg gtggccagtg gccagcagca      300

tcgaccggaa tgaagtgttg gagattcaga ttttcaacta cagcaaagtc ttcagcaaca      360

agctgatagg gaccttctgc atggtgctgc agaaagtggt ggaggagaat cgggtagagg      420

tgaccgacac gctgatggat gacagcaatg ctatcatcaa gaccagcctg agcatggagg      480

tccggtatca ggccacagat ggcactgtgg gcccctggga tgatggagac ttcctgggag      540

atgaatccct ccaggaggag aaggacagcc aggagacaga tgggctgcta cctggttccc      600

gacccagcac ccggatatct ggcgagaaga gctttcgcag agcgggaagg agtgtgttct      660

cggccatgaa actcggcaaa actcggtccc acaaagagga gccccaaaga caagatgagc      720

cagcagtgct ggagatggag gacctggacc acctagccat tcagctgggg gatgggctgg      780

atcctgactc cgtgtctcta gcctcggtca ccgctctcac cagcaatgtc tccaacaaac      840

ggtctaagcc agatattaag atggagccca gtgctggaag gcccatggat taccaggtca      900

gcatcacagt gattgaggct cggcagctgg tgggcttgaa catggaccct gtggtgtgtg      960

tggaggtggg tgatgacaag aaatacacgt caatgaagga gtccacaaac tgcccttact     1020

acaacgagta ctttgtcttc gacttccatg tctctcctga tgtcatgttt gacaagatca     1080

tcaagatctc ggttatccat tctaagaacc tgcttcggag cggcaccctg gtgggttcct     1140

tcaaaatgga tgtggggact gtgtattccc agcctgaaca ccagttccat cacaaatggg     1200

ccatcctgtc agaccccgat gacatctctg ctgggttgaa gggttatgta aagtgtgatg     1260

tcgctgtggt gggcaaggga gacaacatca agacacccca caaggccaac gagacggatg     1320

aggacgacat tgaagggaac ttgctgctcc ccgagggcgt gccccccgaa cggcagtggg     1380

cacggttcta tgtgaaaatt taccgagcag agggactgcc ccggatgaac acaagcctca     1440

tggccaacgt gaagaaggcg ttcatcggtg agaacaagga cctcgtcgac ccctatgtgc     1500

aagtcttctt tgctggacaa aagggcaaaa catcagtgca gaagagcagc tatgagccgc     1560

tatggaatga gcaggtcgtc ttcacagact tgttcccccc actctgcaaa cgcatgaagg     1620

tgcagatccg ggactctgac aaggtcaatg atgtggccat cggcacccac ttcatcgacc     1680

tgcgcaagat ttccaacgat ggagacaaag gcttcctgcc taccctcggt ccagcctggg     1740

tgaacatgta cggctccacg cgcaactaca cactgctgga cgagcaccag gacttgaatg     1800

aaggcctggg ggagggtgtg tccttccggg cccgcctcat gttgggacta gctgtggaga     1860

tcctggacac ctccaaccca gagctcacca gctccacgga ggtgcaggtg gagcaggcca     1920

cgcctgtctc ggagagctgc acagggagaa tggaagaatt ttttctattt ggagccttct     1980

tggaagcctc aatgattgac cggaaaaatg gggacaagcc aattaccttt gaggtgacca     2040

taggaaacta cggcaatgaa gtcgatggta tgtcccggcc cctgaggcct cggccccgga     2100

aagagcctgg ggatgaagaa gaggtagacc tgattcagaa ctccagtgac gatgaaggtg     2160

acgaagccgg ggacctggcc tcggtgtcct ccaccccacc tatgcggccc cagatcacgg     2220

acaggaacta tttccacctg ccctacctgg agcgcaagcc ctgcatctat atcaagagct     2280

ggtggcctga ccagaggcgg cgcctctaca atgccaacat catggatcac attgctgaca     2340

agctggaaga aggcctgaat gatgtacagg agatgatcaa aacggagaag tcctacccgg     2400

agcgccgcct gcggggtgtg ctagaggaac tcagctgtgg ctgccaccgc ttcctctccc     2460

tctcggacaa ggaccagggc cgctcgtccc gcaccaggct ggatcgagag cgtcttaagt     2520

cctgtatgag ggagttggag agcatgggac agcaggccaa gagcctgagg gctcaggtga     2580

agcggcacac tgttcgggac aagctgaggt catgccagaa ctttctgcag aagctacgct     2640

tcctggcgga tgagccccag cacagcattc ctgatgtgtt catttggatg atgagcaaca     2700

acaaacgtat cgcctatgcc cgcgtgcctt ccaaagacct gctcttctcc atcgtggagg     2760

aggaactggg caaggactgc gccaaagtca agaccctctt cctgaagctg ccagggaaga     2820

ggggcttcgg ctcggcaggc tggacagtac aggccaagct ggagctctac ctgtggctgg     2880

gcctcagcaa gcagcgaaag gacttcctgt gtggtctgcc ctgtggcttc gaggaggtca     2940

aggcagccca aggcctgggc ctgcattcct ttccgcccat cagcctagtc tacaccaaga     3000

agcaagcctt ccagctccga gcacacatgt atcaggcccg aagcctcttt gctgctgaca     3060

gcagtgggct ctctgatccc tttgcccgtg tcttcttcat caaccagagc caatgcactg     3120

aggttctaaa cgagacactg tgtcccacct gggaccagat gctggtattt gacaacctgg     3180

agctgtacgg tgaagctcac gagttacgag atgatccccc catcattgtc attgaaatct     3240

acgaccagga cagcatgggc aaagccgact tcatgggccg gaccttcgcc aagcccctgg     3300

tgaagatggc agatgaagca tactgcccac ctcgcttccc gccgcagctt gagtactacc     3360

agatctaccg aggcagtgcc actgccggag acctactggc tgccttcgag ctgctgcaga     3420

ttgggccatc agggaaggct gacctgccac ccatcaatgg cccagtggac atggacagag     3480

ggcccatcat gcctgtgccc gtgggaatcc ggccagtgct cagcaagtac cgagtggagg     3540

tgctgttctg gggcctgagg gacctaaaga gggtgaacct ggcccaggtg gaccgaccac     3600

gggtggacat cgagtgtgca ggaaaggggg tacaatcctc cctgattcac aattataaga     3660

agaaccccaa cttcaacacg ctggtcaagt ggtttgaagt ggacctcccg gagaatgagc     3720

tcctgcaccc acccttgaac atccgagtgg tagattgccg ggcctttgga cgatacaccc     3780

tggtgggttc ccacgcagtc agctcactga ggcgcttcat ctaccgacct ccagaccgct     3840

cagcccccaa ctggaacacc acagtcaggc tgctccgggg ctgccacagg ctgcgcaatg     3900

ggggcccctc ttctcgcccc acaggggagg ttgtagtaag catggagcct gaggagccag     3960

ttaagaagct ggagaccatg gtgaaactgg atgcgacttc tgatgctgtg gtcaaggtgg     4020

atgtggctga agatgagaag gaaaggaaga agaagaaaaa gaaaggcccg tcagaggagc     4080

cagaggagga agagcccgat gagagcatgc tggattggtg gtccaagtac ttcgcctcca     4140

tcgacacaat gaaggagcaa cttcgacaac atgagacctc tggaactgac ttggaagaga     4200

aggaagagat ggaaagcgct gagggcctga agggaccaat gaagagcaag gagaagtcca     4260

gagctgcaaa ggaggagaaa aagaagaaaa accagagccc tggccctggc cagggatcgg     4320

aggctcctga gaagaagaaa gccaagatcg atgagcttaa ggtgtacccc aaggagctgg     4380

aatcggagtt tgacagcttt gaggactggc tgcacacctt caacctgttg aggggcaaga     4440

cgggagatga tgaggatggc tccacagagg aggagcgcat agtaggccga ttcaagggct     4500

ccctctgtgt gtacaaagtg ccactcccag aagatgtatc tcgagaagct ggctatgatc     4560

ccacctatgg aatgttccag ggcatcccaa gcaatgaccc catcaatgtg ctggtccgaa     4620

tctatgtggt ccgggccaca gacctgcacc cggccgacat caatggcaaa gctgacccct     4680

atattgccat caagttaggc aagaccgaca tccgagacaa ggagaactac atctccaagc     4740

agctcaaccc tgtgtttggg aagtcctttg acattgaggc ctccttcccc atggagtcca     4800

tgttgacagt ggccgtgtac gactgggatc tggtgggcac tgatgacctc atcggagaaa     4860

ccaagattga cctggaaaac cgcttctaca gcaagcatcg cgccacctgc ggcatcgcac     4920

agacctattc catacatggc tacaatatct ggagggaccc catgaagccc agccagatcc     4980

tgacacgcct ctgtaaagag ggcaaagtgg acggccccca ctttggtccc catgggagag     5040

tgagggttgc caaccgtgtc ttcacggggc cttcagaaat agaggatgag aatggtcaga     5100

ggaagcccac agatgagcac gtggcactgt ctgctctgag acactgggag gacatccccc     5160

gggtgggctg ccgccttgtg ccggaacacg tggagaccag gccgctgctc aaccctgaca     5220

agccaggcat tgagcagggc cgcctggagc tgtgggtgga catgttcccc atggacatgc     5280

cagcccctgg gacacctctg gatatatccc ccaggaaacc caagaagtac gagctgcggg     5340

tcatcgtgtg gaacacagac gaggtggtcc tggaagacga tgatttcttc acgggagaga     5400

agtccagtga catttttgtg agggggtggc tgaagggcca gcaggaggac aaacaggaca     5460

cagatgtcca ctatcactcc ctcacggggg agggcaactt caactggaga tacctcttcc     5520

ccttcgacta cctagcggcc gaagagaaga tcgttatgtc caaaaaggag tctatgttct     5580

cctgggatga gacggagtac aagatccctg cgcggctcac cctgcagatc tgggacgctg     5640

accacttctc ggctgacgac ttcctggggg ctatcgagct ggacctgaac cggttcccga     5700

ggggcgctaa gacagccaag cagtgcacca tggagatggc caccggggag gtggacgtac     5760

ccctggtttc catctttaaa cagaaacgtg tcaaaggctg gtggcccctc ctggcccgca     5820

atgagaatga tgagtttgag ctcacaggca aagtggaggc ggagctacac ctactcacgg     5880

cagaggaggc agagaagaac cctgtgggcc tggctcgcaa tgaacctgat cccctagaaa     5940

aacccaatcg gccggacaca agcttcatct ggttcttgaa ccctctcaag tctgcccgct     6000

acttcctgtg gcatacctac cgctggctac tcctcaaatt cctgctgctc ttcctcctgc     6060

tgctgctctt cgccctgttt ctctactctc tgcctggcta cctggccaag aagatccttg     6120

gggcctgagc cctgcagtcg cctaggcctg ccggcctgac acggcattcg tctggttcct     6180

gaacccactc aaatctatca agtacctcat ctgcacccgg tacaagtggc tgatcatcaa     6240

gatcgtgctg gcgctgctgg ggctgctcat gctggccctc ttcctttaca gcctcccagg     6300

ctacatggtc aagaagctcc taggggcctg aagtgtgccc caccccagcc cgctccagca     6360

tccctccagg ggctgctgcg tattttgcct tccctcacct ggactctctc ccaactccct     6420

gaggagccct cccacgcctg ccagccttga gcaagacacc tgcttgctgg acttcatccc     6480

caccccacac ccaaactgtt gcttgcctga tcttgtccca ggcctgcctg gggtttgggg     6540

cacagttggc ctccaaaacc agataccctc ttgtctaaag taccaggttc ctctgcccaa     6600

ccccaagagt ggtagtggcc caaccctccc tgtgctttcc aaatcttgtc ttaaggcacc     6660

agtgaaatta accaagaaac gcggagcaat gcccaaggct ctgatgagta ggaacacgtg     6720

gaaagcacca ggaatgccag cagaggcgag gcggcacacc tctctgcaga gcatccaggc     6780

cgagcggcgg gcagcggcca gctgcttctg cgcatgctct cctcttggct ctgcttcttt     6840

ctcacagtca cagtcacttc acagcttagc cttgggcttc ccatcacttc caggggtgcc     6900

tctgccttgg ccagtgtgtg tcagctagta cacaagctcc aagtgtgaat caggtgtact     6960

ggccgtcctg aagactgact gccctgtcct tcctgccgac agccacaccc gagtgtacac     7020

ttaaagcggt gcccttctgc ctctgtgggc ctgctggctg ctgttccttt cttgagtgtg     7080

attttttttt tctctccctc aataaaataa atcaaactct gagac                     7125


<210>  16
<211>  7065
<212>  DNA
<213>  Mus musculus

<400>  16
ttggttgcct tggtctctgt gggcagcagc aggaggaggc ggcagcagcc agagaagagg       60

gaggcgtgtg agccacactc caccagcgag cttcttcccg ctgctctgga actgcccagg      120

ctctccccac cagcatggcc ctgattgttc acctcaagac tgtctcagag ctccgaggca      180

aaggtgaccg gattgccaaa gtcactttcc gagggcagtc tttctactcc cgggtcctgg      240

agaactgcga gggtgtggct gactttgatg agacgttccg gtggccagtg gccagcagca      300

tcgaccggaa tgaagtgttg gagattcaga ttttcaacta cagcaaagtc ttcagcaaca      360

agctgatagg gaccttctgc atggtgctgc agaaagtggt ggaggagaat cgggtagagg      420

tgaccgacac gctgatggat gacagcaatg ctatcatcaa gaccagcctg agcatggagg      480

tccggtatca ggccacagat ggcactgtgg gcccctggga tgatggagac ttcctgggag      540

atgaatccct ccaggaggag aaggacagcc aggagacaga tgggctgcta cctggttccc      600

gacccagcac ccggatatct ggcgagaaga gctttcgcag agcgggaagg agtgtgttct      660

cggccatgaa actcggcaaa actcggtccc acaaagagga gccccaaaga caagatgagc      720

cagcagtgct ggagatggag gacctggacc acctagccat tcagctgggg gatgggctgg      780

atcctgactc cgtgtctcta gcctcggtca ccgctctcac cagcaatgtc tccaacaaac      840

ggtctaagcc agatattaag atggagccca gtgctggaag gcccatggat taccaggtca      900

gcatcacagt gattgaggct cggcagctgg tgggcttgaa catggaccct gtggtgtgtg      960

tggaggtggg tgatgacaag aaatacacgt caatgaagga gtccacaaac tgcccttact     1020

acaacgagta ctttgtcttc gacttccatg tctctcctga tgtcatgttt gacaagatca     1080

tcaagatctc ggttatccat tctaagaacc tgcttcggag cggcaccctg gtgggttcct     1140

tcaaaatgga tgtggggact gtgtattccc agcctgaaca ccagttccat cacaaatggg     1200

ccatcctgtc agaccccgat gacatctctg ctgggttgaa gggttatgta aagtgtgatg     1260

tcgctgtggt gggcaaggga gacaacatca agacacccca caaggccaac gagacggatg     1320

aggacgacat tgaagggaac ttgctgctcc ccgagggcgt gccccccgaa cggcagtggg     1380

cacggttcta tgtgaaaatt taccgagcag agggactgcc ccggatgaac acaagcctca     1440

tggccaacgt gaagaaggcg ttcatcggtg agaacaagga cctcgtcgac ccctatgtgc     1500

aagtcttctt tgctggacaa aagggcaaaa catcagtgca gaagagcagc tatgagccgc     1560

tatggaatga gcaggtcgtc ttcacagact tgttcccccc actctgcaaa cgcatgaagg     1620

tgcagatccg ggactctgac aaggtcaatg atgtggccat cggcacccac ttcatcgacc     1680

tgcgcaagat ttccaacgat ggagacaaag gcttcctgcc taccctcggt ccagcctggg     1740

tgaacatgta cggctccacg cgcaactaca cactgctgga cgagcaccag gacttgaatg     1800

aaggcctggg ggagggtgtg tccttccggg cccgcctcat gttgggacta gctgtggaga     1860

tcctggacac ctccaaccca gagctcacca gctccacgga ggtgcaggtg gagcaggcca     1920

cgcctgtctc ggagagctgc acagggagaa tggaagaatt ttttctattt ggagccttct     1980

tggaagcctc aatgattgac cggaaaaatg gggacaagcc aattaccttt gaggtgacca     2040

taggaaacta cggcaatgaa gtcgatggta tgtcccggcc cctgaggcct cggccccgga     2100

aagagcctgg ggatgaagaa gaggtagacc tgattcagaa ctccagtgac gatgaaggtg     2160

acgaagccgg ggacctggcc tcggtgtcct ccaccccacc tatgcggccc cagatcacgg     2220

acaggaacta tttccacctg ccctacctgg agcgcaagcc ctgcatctat atcaagagct     2280

ggtggcctga ccagaggcgg cgcctctaca atgccaacat catggatcac attgctgaca     2340

agctggaaga aggcctgaat gatgtacagg agatgatcaa aacggagaag tcctacccgg     2400

agcgccgcct gcggggtgtg ctagaggaac tcagctgtgg ctgccaccgc ttcctctccc     2460

tctcggacaa ggaccagggc cgctcgtccc gcaccaggct ggatcgagag cgtcttaagt     2520

cctgtatgag ggagttggag agcatgggac agcaggccaa gagcctgagg gctcaggtga     2580

agcggcacac tgttcgggac aagctgaggt catgccagaa ctttctgcag aagctacgct     2640

tcctggcgga tgagccccag cacagcattc ctgatgtgtt catttggatg atgagcaaca     2700

acaaacgtat cgcctatgcc cgcgtgcctt ccaaagacct gctcttctcc atcgtggagg     2760

aggaactggg caaggactgc gccaaagtca agaccctctt cctgaagctg ccagggaaga     2820

ggggcttcgg ctcggcaggc tggacagtac aggccaagct ggagctctac ctgtggctgg     2880

gcctcagcaa gcagcgaaag gacttcctgt gtggtctgcc ctgtggcttc gaggaggtca     2940

aggcagccca aggcctgggc ctgcattcct ttccgcccat cagcctagtc tacaccaaga     3000

agcaagcctt ccagctccga gcacacatgt atcaggcccg aagcctcttt gctgctgaca     3060

gcagtgggct ctctgatccc tttgcccgtg tcttcttcat caaccagagc caatgcactg     3120

aggttctaaa cgagacactg tgtcccacct gggaccagat gctggtattt gacaacctgg     3180

agctgtacgg tgaagctcac gagttacgag atgatccccc catcattgtc attgaaatct     3240

acgaccagga cagcatgggc aaagccgact tcatgggccg gaccttcgcc aagcccctgg     3300

tgaagatggc agatgaagca tactgcccac ctcgcttccc gccgcagctt gagtactacc     3360

agatctaccg aggcagtgcc actgccggag acctactggc tgccttcgag ctgctgcaga     3420

ttgggccatc agggaaggct gacctgccac ccatcaatgg cccagtggac atggacagag     3480

ggcccatcat gcctgtgccc gtgggaatcc ggccagtgct cagcaagtac cgagtggagg     3540

tgctgttctg gggcctgagg gacctaaaga gggtgaacct ggcccaggtg gaccgaccac     3600

gggtggacat cgagtgtgca ggaaaggggg tacaatcctc cctgattcac aattataaga     3660

agaaccccaa cttcaacacg ctggtcaagt ggtttgaagt ggacctcccg gagaatgagc     3720

tcctgcaccc acccttgaac atccgagtgg tagattgccg ggcctttgga cgatacaccc     3780

tggtgggttc ccacgcagtc agctcactga ggcgcttcat ctaccgacct ccagaccgct     3840

cagcccccaa ctggaacacc acaggggagg ttgtagtaag catggagcct gaggagccag     3900

ttaagaagct ggagaccatg gtgaaactgg atgcgacttc tgatgctgtg gtcaaggtgg     3960

atgtggctga agatgagaag gaaaggaaga agaagaaaaa gaaaggcccg tcagaggagc     4020

cagaggagga agagcccgat gagagcatgc tggattggtg gtccaagtac ttcgcctcca     4080

tcgacacaat gaaggagcaa cttcgacaac atgagacctc tggaactgac ttggaagaga     4140

aggaagagat ggaaagcgct gagggcctga agggaccaat gaagagcaag gagaagtcca     4200

gagctgcaaa ggaggagaaa aagaagaaaa accagagccc tggccctggc cagggatcgg     4260

aggctcctga gaagaagaaa gccaagatcg atgagcttaa ggtgtacccc aaggagctgg     4320

aatcggagtt tgacagcttt gaggactggc tgcacacctt caacctgttg aggggcaaga     4380

cgggagatga tgaggatggc tccacagagg aggagcgcat agtaggccga ttcaagggct     4440

ccctctgtgt gtacaaagtg ccactcccag aagatgtatc tcgagaagct ggctatgatc     4500

ccacctatgg aatgttccag ggcatcccaa gcaatgaccc catcaatgtg ctggtccgaa     4560

tctatgtggt ccgggccaca gacctgcacc cggccgacat caatggcaaa gctgacccct     4620

atattgccat caagttaggc aagaccgaca tccgagacaa ggagaactac atctccaagc     4680

agctcaaccc tgtgtttggg aagtcctttg acattgaggc ctccttcccc atggagtcca     4740

tgttgacagt ggccgtgtac gactgggatc tggtgggcac tgatgacctc atcggagaaa     4800

ccaagattga cctggaaaac cgcttctaca gcaagcatcg cgccacctgc ggcatcgcac     4860

agacctattc catacatggc tacaatatct ggagggaccc catgaagccc agccagatcc     4920

tgacacgcct ctgtaaagag ggcaaagtgg acggccccca ctttggtccc catgggagag     4980

tgagggttgc caaccgtgtc ttcacggggc cttcagaaat agaggatgag aatggtcaga     5040

ggaagcccac agatgagcac gtggcactgt ctgctctgag acactgggag gacatccccc     5100

gggtgggctg ccgccttgtg ccggaacacg tggagaccag gccgctgctc aaccctgaca     5160

agccaggcat tgagcagggc cgcctggagc tgtgggtgga catgttcccc atggacatgc     5220

cagcccctgg gacacctctg gatatatccc ccaggaaacc caagaagtac gagctgcggg     5280

tcatcgtgtg gaacacagac gaggtggtcc tggaagacga tgatttcttc acgggagaga     5340

agtccagtga catttttgtg agggggtggc tgaagggcca gcaggaggac aaacaggaca     5400

cagatgtcca ctatcactcc ctcacggggg agggcaactt caactggaga tacctcttcc     5460

ccttcgacta cctagcggcc gaagagaaga tcgttatgtc caaaaaggag tctatgttct     5520

cctgggatga gacggagtac aagatccctg cgcggctcac cctgcagatc tgggacgctg     5580

accacttctc ggctgacgac ttcctggggg ctatcgagct ggacctgaac cggttcccga     5640

ggggcgctaa gacagccaag cagtgcacca tggagatggc caccggggag gtggacgtac     5700

ccctggtttc catctttaaa cagaaacgtg tcaaaggctg gtggcccctc ctggcccgca     5760

atgagaatga tgagtttgag ctcacaggca aagtggaggc ggagctacac ctactcacgg     5820

cagaggaggc agagaagaac cctgtgggcc tggctcgcaa tgaacctgat cccctagaaa     5880

aacccaatcg gccggacaca agcttcatct ggttcttgaa ccctctcaag tctgcccgct     5940

acttcctgtg gcatacctac cgctggctac tcctcaaatt cctgctgctc ttcctcctgc     6000

tgctgctctt cgccctgttt ctctactctc tgcctggcta cctggccaag aagatccttg     6060

gggcctgagc cctgcagtcg cctaggcctg ccggcctgac acggcattcg tctggttcct     6120

gaacccactc aaatctatca agtacctcat ctgcacccgg tacaagtggc tgatcatcaa     6180

gatcgtgctg gcgctgctgg ggctgctcat gctggccctc ttcctttaca gcctcccagg     6240

ctacatggtc aagaagctcc taggggcctg aagtgtgccc caccccagcc cgctccagca     6300

tccctccagg ggctgctgcg tattttgcct tccctcacct ggactctctc ccaactccct     6360

gaggagccct cccacgcctg ccagccttga gcaagacacc tgcttgctgg acttcatccc     6420

caccccacac ccaaactgtt gcttgcctga tcttgtccca ggcctgcctg gggtttgggg     6480

cacagttggc ctccaaaacc agataccctc ttgtctaaag taccaggttc ctctgcccaa     6540

ccccaagagt ggtagtggcc caaccctccc tgtgctttcc aaatcttgtc ttaaggcacc     6600

agtgaaatta accaagaaac gcggagcaat gcccaaggct ctgatgagta ggaacacgtg     6660

gaaagcacca ggaatgccag cagaggcgag gcggcacacc tctctgcaga gcatccaggc     6720

cgagcggcgg gcagcggcca gctgcttctg cgcatgctct cctcttggct ctgcttcttt     6780

ctcacagtca cagtcacttc acagcttagc cttgggcttc ccatcacttc caggggtgcc     6840

tctgccttgg ccagtgtgtg tcagctagta cacaagctcc aagtgtgaat caggtgtact     6900

ggccgtcctg aagactgact gccctgtcct tcctgccgac agccacaccc gagtgtacac     6960

ttaaagcggt gcccttctgc ctctgtgggc ctgctggctg ctgttccttt cttgagtgtg     7020

attttttttt tctctccctc aataaaataa atcaaactct gagac                     7065


<210>  17
<211>  6907
<212>  DNA
<213>  Mus musculus

<400>  17
ttggttgcct tggtctctgt gggcagcagc aggaggaggc ggcagcagcc agagaagagg       60

gaggcgtgtg agccacactc caccagcgag cttcttcccg ctgctctgga actgcccagg      120

ctctccccac cagcatggcc ctgattgttc acctcaagac tgtctcagag ctccgaggca      180

aaggtgaccg gattgccaaa gtcactttcc gagggcagtc tttctactcc cgggtcctgg      240

agaactgcga gggtgtggct gactttgatg agacgttccg gtggccagtg gccagcagca      300

tcgaccggaa tgaagtgttg gagattcaga ttttcaacta cagcaaagtc ttcagcaaca      360

agctgatagg gaccttctgc atggtgctgc agaaagtggt ggaggagaat cgggtagagg      420

tgaccgacac gctgatggat gacagcaatg ctatcatcaa gaccagcctg agcatggagg      480

tccggtatca ggccacagat ggcactgtgg gcccctggga tgatggagac ttcctgggag      540

atgaatccct ccaggaggag aaggacagcc aggagacaga tgggctgcta cctggttccc      600

gacccagcac ccggatatct ggcgagaaga gctttcgcag caaaggcaga gagaagacca      660

agggaggcag agatggcgag cacaaagcgg gaaggagtgt gttctcggcc atgaaactcg      720

gcaaaactcg gtcccacaaa gaggagcccc aaagacaaga tgagccagca gtgctggaga      780

tggaggacct ggaccaccta gccattcagc tgggggatgg gctggatcct gactccgtgt      840

ctctagcctc ggtcaccgct ctcaccagca atgtctccaa caaacggtct aagccagata      900

ttaagatgga gcccagtgct ggaaggccca tggattacca ggtcagcatc acagtgattg      960

aggctcggca gctggtgggc ttgaacatgg accctgtggt gtgtgtggag gtgggtgatg     1020

acaagaaata cacgtcaatg aaggagtcca caaactgccc ttactacaac gagtactttg     1080

tcttcgactt ccatgtctct cctgatgtca tgtttgacaa gatcatcaag atctcggtta     1140

tccattctaa gaacctgctt cggagcggca ccctggtggg ttccttcaaa atggatgtgg     1200

ggactgtgta ttcccagcct gaacaccagt tccatcacaa atgggccatc ctgtcagacc     1260

ccgatgacat ctctgctggg ttgaagggtt atgtaaagtg tgatgtcgct gtggtgggca     1320

agggagacaa catcaagaca ccccacaagg ccaacgagac ggatgaggac gacattgaag     1380

ggaacttgct gctccccgag ggcgtgcccc ccgaacggca gtgggcacgg ttctatgtga     1440

aaatttaccg agcagaggga ctgccccgga tgaacacaag cctcatggcc aacgtgaaga     1500

aggcgttcat cggtgagaac aaggacctcg tcgaccccta tgtgcaagtc ttctttgctg     1560

gacaaaaggg caaaacatca gtgcagaaga gcagctatga gccgctatgg aatgagcagg     1620

tcgtcttcac agacttgttc cccccactct gcaaacgcat gaaggtgcag atccgggact     1680

ctgacaaggt caatgatgtg gccatcggca cccacttcat cgacctgcgc aagatttcca     1740

acgatggaga caaaggcttc ctgcctaccc tcggtccagc ctgggtgaac atgtacggct     1800

ccacgcgcaa ctacacactg ctggacgagc accaggactt gaatgaaggc ctgggggagg     1860

gtgtgtcctt ccgggcccgc ctcatgttgg gactagctgt ggagatcctg gacacctcca     1920

acccagagct caccagctcc acggaggtgc aggtggagca ggccacgcct gtctcggaga     1980

gctgcacagg gagaatggaa gaattttttc tatttggagc cttcttggaa gcctcaatga     2040

ttgaccggaa aaatggggac aagccaatta cctttgaggt gaccatagga aactacggca     2100

atgaagtcga tggtatgtcc cggcccctga ggcctcggcc ccggaaagag cctggggatg     2160

aagaagaggt agacctgatt cagaactcca gtgacgatga aggtgacgaa gccggggacc     2220

tggcctcggt gtcctccacc ccacctatgc ggccccagat cacggacagg aactatttcc     2280

acctgcccta cctggagcgc aagccctgca tctatatcaa gagctggtgg cctgaccaga     2340

ggcggcgcct ctacaatgcc aacatcatgg atcacattgc tgacaagctg gaagaaggcc     2400

tgaatgatgt acaggagatg atcaaaacgg agaagtccta cccggagcgc cgcctgcggg     2460

gtgtgctaga ggaactcagc tgtggctgcc accgcttcct ctccctctcg gacaaggacc     2520

agggccgctc gtcccgcacc aggctggatc gagagcgtct taagtcctgt atgagggagt     2580

tggagagcat gggacagcag gccaagagcc tgagggctca ggtgaagcgg cacactgttc     2640

gggacaagct gaggtcatgc cagaactttc tgcagaagct acgcttcctg gcggatgagc     2700

cccagcacag cattcctgat gtgttcattt ggatgatgag caacaacaaa cgtatcgcct     2760

atgcccgcgt gccttccaaa gacctgctct tctccatcgt ggaggaggaa ctgggcaagg     2820

actgcgccaa agtcaagacc ctcttcctga agctgccagg gaagaggggc ttcggctcgg     2880

caggctggac agtacaggcc aagctggagc tctacctgtg gctgggcctc agcaagcagc     2940

gaaaggactt cctgtgtggt ctgccctgtg gcttcgagga ggtcaaggca gcccaaggcc     3000

tgggcctgca ttcctttccg cccatcagcc tagtctacac caagaagcaa gccttccagc     3060

tccgagcaca catgtatcag gcccgaagcc tctttgctgc tgacagcagt gggctctctg     3120

atccctttgc ccgtgtcttc ttcatcaacc agagccaatg cactgaggtt ctaaacgaga     3180

cactgtgtcc cacctgggac cagatgctgg tatttgacaa cctggagctg tacggtgaag     3240

ctcacgagtt acgagatgat ccccccatca ttgtcattga aatctacgac caggacagca     3300

tgggcaaagc cgacttcatg ggccggacct tcgccaagcc cctggtgaag atggcagatg     3360

aagcatactg cccacctcgc ttcccgccgc agcttgagta ctaccagatc taccgaggca     3420

gtgccactgc cggagaccta ctggctgcct tcgagctgct gcagattggg ccatcaggga     3480

aggctgacct gccacccatc aatggcccag tggacatgga cagagggccc atcatgcctg     3540

tgcccgtggg aatccggcca gtgctcagca agtaccgagt ggaggtgctg ttctggggcc     3600

tgagggacct aaagagggtg aacctggccc aggtggaccg accacgggtg gacatcgagt     3660

gtgcaggaaa gggggtacaa tcctccctga ttcacaatta taagaagaac cccaacttca     3720

acacgctggt caagtggttt gaagtggacc tcccggagaa tgagctcctg cacccaccct     3780

tgaacatccg agtggtagat tgccgggcct ttggacgata caccctggtg ggttcccacg     3840

cagtcagctc actgaggcgc ttcatctacc gacctccaga ccgctcagcc cccaactgga     3900

acaccacagg ggaggttgta gtaagcatgg agcctgagga gccagttaag aagctggaga     3960

ccatggtgaa actggatgcg acttctgatg ctgtggtcaa ggtggatgtg gctgaagatg     4020

agaaggaaag gaagaagaag aaaaagaaag gcccgtcaga ggagccagag gaggaagagc     4080

ccgatgagag catgctggat tggtggtcca agtacttcgc ctccatcgac acaatgaagg     4140

agcaacttcg acaacatgag acctctggaa ctgacttgga agagaaggaa gagatggaaa     4200

gcgctgaggg cctgaaggga ccaatgaaga gcaaggagaa gtccagagct gcaaaggagg     4260

agaaaaagaa gaaaaaccag agccctggcc ctggccaggg atcggaggct cctgagaaga     4320

agaaagccaa gatcgatgag cttaaggtgt accccaagga gctggaatcg gagtttgaca     4380

gctttgagga ctggctgcac accttcaacc tgttgagggg caagacggga gatgatgagg     4440

atggctccac agaggaggag cgcatagtag gccgattcaa gggctccctc tgtgtgtaca     4500

aagtgccact cccagaagat gtatctcgag aagctggcta tgatcccacc tatggaatgt     4560

tccagggcat cccaagcaat gaccccatca atgtgctggt ccgaatctat gtggtccggg     4620

ccacagacct gcacccggcc gacatcaatg gcaaagctga cccctatatt gccatcaagt     4680

taggcaagac cgacatccga gacaaggaga actacatctc caagcagctc aaccctgtgt     4740

ttgggaagtc ctttgacatt gaggcctcct tccccatgga gtccatgttg acagtggccg     4800

tgtacgactg ggatctggtg ggcactgatg acctcatcgg agaaaccaag attgacctgg     4860

aaaaccgctt ctacagcaag catcgcgcca cctgcggcat cgcacagacc tattccatac     4920

atggctacaa tatctggagg gaccccatga agcccagcca gatcctgaca cgcctctgta     4980

aagagggcaa agtggacggc ccccactttg gtccccatgg gagagtgagg gttgccaacc     5040

gtgtcttcac ggggccttca gaaatagagg atgagaatgg tcagaggaag cccacagatg     5100

agcacgtggc actgtctgct ctgagacact gggaggacat cccccgggtg ggctgccgcc     5160

ttgtgccgga acacgtggag accaggccgc tgctcaaccc tgacaagcca ggcattgagc     5220

agggccgcct ggagctgtgg gtggacatgt tccccatgga catgccagcc cctgggacac     5280

ctctggatat atcccccagg aaacccaaga agtacgagct gcgggtcatc gtgtggaaca     5340

cagacgaggt ggtcctggaa gacgatgatt tcttcacggg agagaagtcc agtgacattt     5400

ttgtgagggg gtggctgaag ggccagcagg aggacaaaca ggacacagat gtccactatc     5460

actccctcac gggggagggc aacttcaact ggagatacct cttccccttc gactacctag     5520

cggccgaaga gaagatcgtt atgtccaaaa aggagtctat gttctcctgg gatgagacgg     5580

agtacaagat ccctgcgcgg ctcaccctgc agatctggga cgctgaccac ttctcggctg     5640

acgacttcct gggggctatc gagctggacc tgaaccggtt cccgaggggc gctaagacag     5700

ccaagcagtg caccatggag atggccaccg gggaggtgga cgtacccctg gtttccatct     5760

ttaaacagaa acgtgtcaaa ggctggtggc ccctcctggc ccgcaatgag aatgatgagt     5820

ttgagctcac aggcaaagtg gaggcggagc tacacctact cacggcagag gaggcagaga     5880

agaaccctgt gggcctggct cgcaatgaac ctgatcccct agaaaaaccc aaccggcctg     5940

acacggcatt cgtctggttc ctgaacccac tcaaatctat caagtacctc atctgcaccc     6000

ggtacaagtg gctgatcatc aagatcgtgc tggcgctgct ggggctgctc atgctggccc     6060

tcttccttta cagcctccca ggctacatgg tcaagaagct cctaggggcc tgaagtgtgc     6120

cccaccccag cccgctccag catccctcca ggggctgctg cgtattttgc cttccctcac     6180

ctggactctc tcccaactcc ctgaggagcc ctcccacgcc tgccagcctt gagcaagaca     6240

cctgcttgct ggacttcatc cccaccccac acccaaactg ttgcttgcct gatcttgtcc     6300

caggcctgcc tggggtttgg ggcacagttg gcctccaaaa ccagataccc tcttgtctaa     6360

agtaccaggt tcctctgccc aaccccaaga gtggtagtgg cccaaccctc cctgtgcttt     6420

ccaaatcttg tcttaaggca ccagtgaaat taaccaagaa acgcggagca atgcccaagg     6480

ctctgatgag taggaacacg tggaaagcac caggaatgcc agcagaggcg aggcggcaca     6540

cctctctgca gagcatccag gccgagcggc gggcagcggc cagctgcttc tgcgcatgct     6600

ctcctcttgg ctctgcttct ttctcacagt cacagtcact tcacagctta gccttgggct     6660

tcccatcact tccaggggtg cctctgcctt ggccagtgtg tgtcagctag tacacaagct     6720

ccaagtgtga atcaggtgta ctggccgtcc tgaagactga ctgccctgtc cttcctgccg     6780

acagccacac ccgagtgtac acttaaagcg gtgcccttct gcctctgtgg gcctgctggc     6840

tgctgttcct ttcttgagtg tgattttttt tttctctccc tcaataaaat aaatcaaact     6900

ctgagac                                                               6907


<210>  18
<211>  6862
<212>  DNA
<213>  Mus musculus

<400>  18
ttggttgcct tggtctctgt gggcagcagc aggaggaggc ggcagcagcc agagaagagg       60

gaggcgtgtg agccacactc caccagcgag cttcttcccg ctgctctgga actgcccagg      120

ctctccccac cagcatggcc ctgattgttc acctcaagac tgtctcagag ctccgaggca      180

aaggtgaccg gattgccaaa gtcactttcc gagggcagtc tttctactcc cgggtcctgg      240

agaactgcga gggtgtggct gactttgatg agacgttccg gtggccagtg gccagcagca      300

tcgaccggaa tgaagtgttg gagattcaga ttttcaacta cagcaaagtc ttcagcaaca      360

agctgatagg gaccttctgc atggtgctgc agaaagtggt ggaggagaat cgggtagagg      420

tgaccgacac gctgatggat gacagcaatg ctatcatcaa gaccagcctg agcatggagg      480

tccggtatca ggccacagat ggcactgtgg gcccctggga tgatggagac ttcctgggag      540

atgaatccct ccaggaggag aaggacagcc aggagacaga tgggctgcta cctggttccc      600

gacccagcac ccggatatct ggcgagaaga gctttcgcag agcgggaagg agtgtgttct      660

cggccatgaa actcggcaaa actcggtccc acaaagagga gccccaaaga caagatgagc      720

cagcagtgct ggagatggag gacctggacc acctagccat tcagctgggg gatgggctgg      780

atcctgactc cgtgtctcta gcctcggtca ccgctctcac cagcaatgtc tccaacaaac      840

ggtctaagcc agatattaag atggagccca gtgctggaag gcccatggat taccaggtca      900

gcatcacagt gattgaggct cggcagctgg tgggcttgaa catggaccct gtggtgtgtg      960

tggaggtggg tgatgacaag aaatacacgt caatgaagga gtccacaaac tgcccttact     1020

acaacgagta ctttgtcttc gacttccatg tctctcctga tgtcatgttt gacaagatca     1080

tcaagatctc ggttatccat tctaagaacc tgcttcggag cggcaccctg gtgggttcct     1140

tcaaaatgga tgtggggact gtgtattccc agcctgaaca ccagttccat cacaaatggg     1200

ccatcctgtc agaccccgat gacatctctg ctgggttgaa gggttatgta aagtgtgatg     1260

tcgctgtggt gggcaaggga gacaacatca agacacccca caaggccaac gagacggatg     1320

aggacgacat tgaagggaac ttgctgctcc ccgagggcgt gccccccgaa cggcagtggg     1380

cacggttcta tgtgaaaatt taccgagcag agggactgcc ccggatgaac acaagcctca     1440

tggccaacgt gaagaaggcg ttcatcggtg agaacaagga cctcgtcgac ccctatgtgc     1500

aagtcttctt tgctggacaa aagggcaaaa catcagtgca gaagagcagc tatgagccgc     1560

tatggaatga gcaggtcgtc ttcacagact tgttcccccc actctgcaaa cgcatgaagg     1620

tgcagatccg ggactctgac aaggtcaatg atgtggccat cggcacccac ttcatcgacc     1680

tgcgcaagat ttccaacgat ggagacaaag gcttcctgcc taccctcggt ccagcctggg     1740

tgaacatgta cggctccacg cgcaactaca cactgctgga cgagcaccag gacttgaatg     1800

aaggcctggg ggagggtgtg tccttccggg cccgcctcat gttgggacta gctgtggaga     1860

tcctggacac ctccaaccca gagctcacca gctccacgga ggtgcaggtg gagcaggcca     1920

cgcctgtctc ggagagctgc acagggagaa tggaagaatt ttttctattt ggagccttct     1980

tggaagcctc aatgattgac cggaaaaatg gggacaagcc aattaccttt gaggtgacca     2040

taggaaacta cggcaatgaa gtcgatggta tgtcccggcc cctgaggcct cggccccgga     2100

aagagcctgg ggatgaagaa gaggtagacc tgattcagaa ctccagtgac gatgaaggtg     2160

acgaagccgg ggacctggcc tcggtgtcct ccaccccacc tatgcggccc cagatcacgg     2220

acaggaacta tttccacctg ccctacctgg agcgcaagcc ctgcatctat atcaagagct     2280

ggtggcctga ccagaggcgg cgcctctaca atgccaacat catggatcac attgctgaca     2340

agctggaaga aggcctgaat gatgtacagg agatgatcaa aacggagaag tcctacccgg     2400

agcgccgcct gcggggtgtg ctagaggaac tcagctgtgg ctgccaccgc ttcctctccc     2460

tctcggacaa ggaccagggc cgctcgtccc gcaccaggct ggatcgagag cgtcttaagt     2520

cctgtatgag ggagttggag agcatgggac agcaggccaa gagcctgagg gctcaggtga     2580

agcggcacac tgttcgggac aagctgaggt catgccagaa ctttctgcag aagctacgct     2640

tcctggcgga tgagccccag cacagcattc ctgatgtgtt catttggatg atgagcaaca     2700

acaaacgtat cgcctatgcc cgcgtgcctt ccaaagacct gctcttctcc atcgtggagg     2760

aggaactggg caaggactgc gccaaagtca agaccctctt cctgaagctg ccagggaaga     2820

ggggcttcgg ctcggcaggc tggacagtac aggccaagct ggagctctac ctgtggctgg     2880

gcctcagcaa gcagcgaaag gacttcctgt gtggtctgcc ctgtggcttc gaggaggtca     2940

aggcagccca aggcctgggc ctgcattcct ttccgcccat cagcctagtc tacaccaaga     3000

agcaagcctt ccagctccga gcacacatgt atcaggcccg aagcctcttt gctgctgaca     3060

gcagtgggct ctctgatccc tttgcccgtg tcttcttcat caaccagagc caatgcactg     3120

aggttctaaa cgagacactg tgtcccacct gggaccagat gctggtattt gacaacctgg     3180

agctgtacgg tgaagctcac gagttacgag atgatccccc catcattgtc attgaaatct     3240

acgaccagga cagcatgggc aaagccgact tcatgggccg gaccttcgcc aagcccctgg     3300

tgaagatggc agatgaagca tactgcccac ctcgcttccc gccgcagctt gagtactacc     3360

agatctaccg aggcagtgcc actgccggag acctactggc tgccttcgag ctgctgcaga     3420

ttgggccatc agggaaggct gacctgccac ccatcaatgg cccagtggac atggacagag     3480

ggcccatcat gcctgtgccc gtgggaatcc ggccagtgct cagcaagtac cgagtggagg     3540

tgctgttctg gggcctgagg gacctaaaga gggtgaacct ggcccaggtg gaccgaccac     3600

gggtggacat cgagtgtgca ggaaaggggg tacaatcctc cctgattcac aattataaga     3660

agaaccccaa cttcaacacg ctggtcaagt ggtttgaagt ggacctcccg gagaatgagc     3720

tcctgcaccc acccttgaac atccgagtgg tagattgccg ggcctttgga cgatacaccc     3780

tggtgggttc ccacgcagtc agctcactga ggcgcttcat ctaccgacct ccagaccgct     3840

cagcccccaa ctggaacacc acaggggagg ttgtagtaag catggagcct gaggagccag     3900

ttaagaagct ggagaccatg gtgaaactgg atgcgacttc tgatgctgtg gtcaaggtgg     3960

atgtggctga agatgagaag gaaaggaaga agaagaaaaa gaaaggcccg tcagaggagc     4020

cagaggagga agagcccgat gagagcatgc tggattggtg gtccaagtac ttcgcctcca     4080

tcgacacaat gaaggagcaa cttcgacaac atgagacctc tggaactgac ttggaagaga     4140

aggaagagat ggaaagcgct gagggcctga agggaccaat gaagagcaag gagaagtcca     4200

gagctgcaaa ggaggagaaa aagaagaaaa accagagccc tggccctggc cagggatcgg     4260

aggctcctga gaagaagaaa gccaagatcg atgagcttaa ggtgtacccc aaggagctgg     4320

aatcggagtt tgacagcttt gaggactggc tgcacacctt caacctgttg aggggcaaga     4380

cgggagatga tgaggatggc tccacagagg aggagcgcat agtaggccga ttcaagggct     4440

ccctctgtgt gtacaaagtg ccactcccag aagatgtatc tcgagaagct ggctatgatc     4500

ccacctatgg aatgttccag ggcatcccaa gcaatgaccc catcaatgtg ctggtccgaa     4560

tctatgtggt ccgggccaca gacctgcacc cggccgacat caatggcaaa gctgacccct     4620

atattgccat caagttaggc aagaccgaca tccgagacaa ggagaactac atctccaagc     4680

agctcaaccc tgtgtttggg aagtcctttg acattgaggc ctccttcccc atggagtcca     4740

tgttgacagt ggccgtgtac gactgggatc tggtgggcac tgatgacctc atcggagaaa     4800

ccaagattga cctggaaaac cgcttctaca gcaagcatcg cgccacctgc ggcatcgcac     4860

agacctattc catacatggc tacaatatct ggagggaccc catgaagccc agccagatcc     4920

tgacacgcct ctgtaaagag ggcaaagtgg acggccccca ctttggtccc catgggagag     4980

tgagggttgc caaccgtgtc ttcacggggc cttcagaaat agaggatgag aatggtcaga     5040

ggaagcccac agatgagcac gtggcactgt ctgctctgag acactgggag gacatccccc     5100

gggtgggctg ccgccttgtg ccggaacacg tggagaccag gccgctgctc aaccctgaca     5160

agccaggcat tgagcagggc cgcctggagc tgtgggtgga catgttcccc atggacatgc     5220

cagcccctgg gacacctctg gatatatccc ccaggaaacc caagaagtac gagctgcggg     5280

tcatcgtgtg gaacacagac gaggtggtcc tggaagacga tgatttcttc acgggagaga     5340

agtccagtga catttttgtg agggggtggc tgaagggcca gcaggaggac aaacaggaca     5400

cagatgtcca ctatcactcc ctcacggggg agggcaactt caactggaga tacctcttcc     5460

ccttcgacta cctagcggcc gaagagaaga tcgttatgtc caaaaaggag tctatgttct     5520

cctgggatga gacggagtac aagatccctg cgcggctcac cctgcagatc tgggacgctg     5580

accacttctc ggctgacgac ttcctggggg ctatcgagct ggacctgaac cggttcccga     5640

ggggcgctaa gacagccaag cagtgcacca tggagatggc caccggggag gtggacgtac     5700

ccctggtttc catctttaaa cagaaacgtg tcaaaggctg gtggcccctc ctggcccgca     5760

atgagaatga tgagtttgag ctcacaggca aagtggaggc ggagctacac ctactcacgg     5820

cagaggaggc agagaagaac cctgtgggcc tggctcgcaa tgaacctgat cccctagaaa     5880

aacccaaccg gcctgacacg gcattcgtct ggttcctgaa cccactcaaa tctatcaagt     5940

acctcatctg cacccggtac aagtggctga tcatcaagat cgtgctggcg ctgctggggc     6000

tgctcatgct ggccctcttc ctttacagcc tcccaggcta catggtcaag aagctcctag     6060

gggcctgaag tgtgccccac cccagcccgc tccagcatcc ctccaggggc tgctgcgtat     6120

tttgccttcc ctcacctgga ctctctccca actccctgag gagccctccc acgcctgcca     6180

gccttgagca agacacctgc ttgctggact tcatccccac cccacaccca aactgttgct     6240

tgcctgatct tgtcccaggc ctgcctgggg tttggggcac agttggcctc caaaaccaga     6300

taccctcttg tctaaagtac caggttcctc tgcccaaccc caagagtggt agtggcccaa     6360

ccctccctgt gctttccaaa tcttgtctta aggcaccagt gaaattaacc aagaaacgcg     6420

gagcaatgcc caaggctctg atgagtagga acacgtggaa agcaccagga atgccagcag     6480

aggcgaggcg gcacacctct ctgcagagca tccaggccga gcggcgggca gcggccagct     6540

gcttctgcgc atgctctcct cttggctctg cttctttctc acagtcacag tcacttcaca     6600

gcttagcctt gggcttccca tcacttccag gggtgcctct gccttggcca gtgtgtgtca     6660

gctagtacac aagctccaag tgtgaatcag gtgtactggc cgtcctgaag actgactgcc     6720

ctgtccttcc tgccgacagc cacacccgag tgtacactta aagcggtgcc cttctgcctc     6780

tgtgggcctg ctggctgctg ttcctttctt gagtgtgatt ttttttttct ctccctcaat     6840

aaaataaatc aaactctgag ac                                              6862


<210>  19
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac       60

gcgaatttta acaaaat                                                      77


<210>  20
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ct                                                82


<210>  21
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
gataggcacc tattggtctt actgacatcc actttgcctt tctctccaca g                51


<210>  22
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
gcctgcaaga actggttcag cagcctgagc cacttcgtga tccacctg                    48


<210>  23
<211>  548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
gatccaatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg       60

ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt      120

cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg      180

agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc      240

ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc      300

tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc      360

ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc      420

tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg      480

ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc      540

gtcttcga                                                               548


<210>  24
<211>  454
<212>  DNA
<213>  Mus musculus

<400>  24
ctgcagctca gcctactact tgctttccag gctgttccta gttcccatgt cagctgcttg       60

tgctttccag agacaaaaca ggaataatag atgtcattaa atatacattg ggccccaggc      120

ggtcaatgtg gcagcctgag cctcctttcc atctctgtgg aggcagacat aggaccccca      180

acaaacagca tgcaggttgg gagccagcca caggacccag gtaaggggcc ctgggtcctt      240

aagcttctgc cactggctcc ggcattgcag agagaagaga aggggcggca gagctgaacc      300

ttagccttgc cttcctgggt acccttctga gcctcactgt cttctgtgag atgggcaaag      360

tgcgggtgtg actccttggc aacggtgtta caccagggca ggtaaagttg tagttatttg      420

tggggtacac caggactgtt aaaggtgtaa ctat                                  454


<210>  25
<211>  1157
<212>  DNA
<213>  Mus musculus

<400>  25
ggtctcaccc agcattttca cttctaataa gttcaaatgt gatacggcac ctttctaaaa       60

attagttttc agggaaatag ggttcaaaac tggtagtggt agggtccatt ctcacgaccc      120

ccaggcctgc taaccctgac caagctacct attacttacc ctcctctttc tcctcctcct      180

ctttctcctt ctcctgcttc ccctcttcct tctccctccc ttcctctccc tcctccccct      240

ccttggctgt gatcagatcc agagcctgaa tgagcctcct gaccccacac ccccactagc      300

atgggcctgc aagtgcccag aagtccctcc tgcctcctaa actgcccagc cgatccatta      360

gctcttcctt cttcccagtg aaagaagcag gcacagcctg tccctcccgt tctacagaaa      420

ggaagctaca gcacagggag ggccaaaggc cttcctggga ctagacagtt gatcaacagc      480

aggactggag agctgggctc catttttgtt ccttggtgcc ctgcccctcc ccatgacctg      540

cagagacatt cagcctgcca ggctttatga ggtgggagct gggctctccc tgatgtatta      600

ttcagctccc tggagttggc cagctcctgt tacactggcc acagccctgg gcatccgctt      660

ctcacttcta gtttcccctc caaggtaatg tggtgggtca tgatcattct atcctggctt      720

cagggacctg actccacttt ggggccattc gaggggtcta gggtagatga tgtccccctg      780

tggggattaa tgtcctgctc tgtaaaactg agctagctga gatccaggag ggcttggcca      840

gagacagcaa gttgttgcca tggtgacttt aaagccaggt tgctgcccca gcacaggcct      900

cccagtctac cctcactaga aaacaacacc caggcacttt ccaccacctc tcaaaggtga      960

aacccaaggc tggtctagag aatgaattat ggatcctcgc tgtccgtgcc acccagctag     1020

tcccagcggc tcagacactg aggagagact gtaggttcag ctacaagcaa aaagacctag     1080

ctggtctcca agcagtgtct ccaagtccct gaacctgtga cacctgcccc aggcatcatc     1140

aggcacagag ggccacc                                                    1157


<210>  26
<211>  76
<212>  DNA
<213>  Mus musculus

<400>  26
cccatgtcag ctgcttgtgc tttccagaga caaaacagga ataatagatg tcattaaata       60

tacattgggc cccagg                                                       76


<210>  27
<211>  95
<212>  DNA
<213>  Mus musculus

<400>  27
agcctgagcc tcctttccat ctctgtggag gcagacatag gacccccaac aaacagcatg       60

caggttggga gccagccaca ggacccaggt aaggg                                  95


<210>  28
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
cccatgtcag ctgcttgtgc tttccagaga caaaacagga ataatagatg tcattaaata       60

tacattgggc cccaggagcc tgagcctcct ttccatctct gtggaggcag acataggacc      120

cccaacaaac agcatgcagg ttgggagcca gccacaggac ccaggtaagg g               171


<210>  29
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29
agcctgagcc tcctttccat ctctgtggag gcagacatag gacccccaac aaacagcatg       60

caggttggga gccagccaca ggacccaggt aagggcccat gtcagctgct tgtgctttcc      120

agagacaaaa caggaataat agatgtcatt aaatatacat tgggccccag g               171


<210>  30
<211>  184
<212>  DNA
<213>  Mus musculus

<400>  30
cccatgtcag ctgcttgtgc tttccagaga caaaacagga ataatagatg tcattaaata       60

tacattgggc cccaggcggt caatgtggca gcctgagcct cctttccatc tctgtggagg      120

cagacatagg acccccaaca aacagcatgc aggttgggag ccagccacag gacccaggta      180

aggg                                                                   184


<210>  31
<211>  82
<212>  DNA
<213>  Mus musculus

<400>  31
tgaggtggga gctgggctct ccctgatgta ttattcagct ccctggagtt ggccagctcc       60

tgttacactg gccacagccc tg                                                82


<210>  32
<211>  106
<212>  DNA
<213>  Mus musculus

<400>  32
cacaggcctc ccagtctacc ctcactagaa aacaacaccc aggcactttc caccacctct       60

caaaggtgaa acccaaggct ggtctagaga atgaattatg gatcct                     106


<210>  33
<211>  188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
tgaggtggga gctgggctct ccctgatgta ttattcagct ccctggagtt ggccagctcc       60

tgttacactg gccacagccc tgcacaggcc tcccagtcta ccctcactag aaaacaacac      120

ccaggcactt tccaccacct ctcaaaggtg aaacccaagg ctggtctaga gaatgaatta      180

tggatcct                                                               188


<210>  34
<211>  188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
cacaggcctc ccagtctacc ctcactagaa aacaacaccc aggcactttc caccacctct       60

caaaggtgaa acccaaggct ggtctagaga atgaattatg gatccttgag gtgggagctg      120

ggctctccct gatgtattat tcagctccct ggagttggcc agctcctgtt acactggcca      180

cagccctg                                                               188


<210>  35
<211>  430
<212>  DNA
<213>  Mus musculus

<400>  35
tgaggtggga gctgggctct ccctgatgta ttattcagct ccctggagtt ggccagctcc       60

tgttacactg gccacagccc tgggcatccg cttctcactt ctagtttccc ctccaaggta      120

atgtggtggg tcatgatcat tctatcctgg cttcagggac ctgactccac tttggggcca      180

ttcgaggggt ctagggtaga tgatgtcccc ctgtggggat taatgtcctg ctctgtaaaa      240

ctgagctagc tgagatccag gagggcttgg ccagagacag caagttgttg ccatggtgac      300

tttaaagcca ggttgctgcc ccagcacagg cctcccagtc taccctcact agaaaacaac      360

acccaggcac tttccaccac ctctcaaagg tgaaacccaa ggctggtcta gagaatgaat      420

tatggatcct                                                             430


<210>  36
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
ctgcagctca gcctactact tgctttccag gctgttccta gttcccatgt cagctgcttg       60

tgctttccag agacaaaaca ggaataatag atgtcattaa atatacattg ggccccaggc      120

ggtcaatgtg gcagcctgag cctcctttcc atctctgtgg aggcagacat aggaccccca      180

acaaacagca tgcaggttgg gagccagcca caggacccag gtaaggggcc ctgggtcctt      240

aagcttctgc cactggctcc ggcattgcag agagaagaga aggggcggca gagctgaacc      300

ttagccttgc cttcctgggt acccttctga gcctcactgt cttctgtgag atgggcaaag      360

tgcgggtgtg actccttggc aacggtgtta caccagggca ggtaaagttg tagttatttg      420

tggggtacac caggactgtt aaaggtgtaa ctatggtctc acccagcatt ttcacttcta      480

ataagttcaa atgtgatacg gcacctttct aaaaattagt tttcagggaa atagggttca      540

aaactggtag tggtagggtc cattctcacg acccccaggc ctgctaaccc tgaccaagct      600

acctattact taccctcctc tttctcctcc tcctctttct ccttctcctg cttcccctct      660

tccttctccc tcccttcctc tccctcctcc ccctccttgg ctgtgatcag atccagagcc      720

tgaatgagcc tcctgacccc acacccccac tagcatgggc ctgcaagtgc ccagaagtcc      780

ctcctgcctc ctaaactgcc cagccgatcc attagctctt ccttcttccc agtgaaagaa      840

gcaggcacag cctgtccctc ccgttctaca gaaaggaagc tacagcacag ggagggccaa      900

aggccttcct gggactagac agttgatcaa cagcaggact ggagagctgg gctccatttt      960

tgttccttgg tgccctgccc ctccccatga cctgcagaga cattcagcct gccaggcttt     1020

atgaggtggg agctgggctc tccctgatgt attattcagc tccctggagt tggccagctc     1080

ctgttacact ggccacagcc ctgggcatcc gcttctcact tctagtttcc cctccaaggt     1140

aatgtggtgg gtcatgatca ttctatcctg gcttcaggga cctgactcca ctttggggcc     1200

attcgagggg tctagggtag atgatgtccc cctgtgggga ttaatgtcct gctctgtaaa     1260

actgagctag ctgagatcca ggagggcttg gccagagaca gcaagttgtt gccatggtga     1320

ctttaaagcc aggttgctgc cccagcacag gcctcccagt ctaccctcac tagaaaacaa     1380

cacccaggca ctttccacca cctctcaaag gtgaaaccca aggctggtct agagaatgaa     1440

ttatggatcc tcgctgtccg tgccacccag ctagtcccag cggctcagac actgaggaga     1500

gactgtaggt tcagctacaa gcaaaaagac ctagctggtc tccaagcagt gtctccaagt     1560

ccctgaacct gtgacacctg ccccaggcat catcaggcac agagggccac c              1611


<210>  37
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37
ggtctcaccc agcattttca cttctaataa gttcaaatgt gatacggcac ctttctaaaa       60

attagttttc agggaaatag ggttcaaaac tggtagtggt agggtccatt ctcacgaccc      120

ccaggcctgc taaccctgac caagctacct attacttacc ctcctctttc tcctcctcct      180

ctttctcctt ctcctgcttc ccctcttcct tctccctccc ttcctctccc tcctccccct      240

ccttggctgt gatcagatcc agagcctgaa tgagcctcct gaccccacac ccccactagc      300

atgggcctgc aagtgcccag aagtccctcc tgcctcctaa actgcccagc cgatccatta      360

gctcttcctt cttcccagtg aaagaagcag gcacagcctg tccctcccgt tctacagaaa      420

ggaagctaca gcacagggag ggccaaaggc cttcctggga ctagacagtt gatcaacagc      480

aggactggag agctgggctc catttttgtt ccttggtgcc ctgcccctcc ccatgacctg      540

cagagacatt cagcctgcca ggctttatga ggtgggagct gggctctccc tgatgtatta      600

ttcagctccc tggagttggc cagctcctgt tacactggcc acagccctgg gcatccgctt      660

ctcacttcta gtttcccctc caaggtaatg tggtgggtca tgatcattct atcctggctt      720

cagggacctg actccacttt ggggccattc gaggggtcta gggtagatga tgtccccctg      780

tggggattaa tgtcctgctc tgtaaaactg agctagctga gatccaggag ggcttggcca      840

gagacagcaa gttgttgcca tggtgacttt aaagccaggt tgctgcccca gcacaggcct      900

cccagtctac cctcactaga aaacaacacc caggcacttt ccaccacctc tcaaaggtga      960

aacccaaggc tggtctagag aatgaattat ggatcctcgc tgtccgtgcc acccagctag     1020

tcccagcggc tcagacactg aggagagact gtaggttcag ctacaagcaa aaagacctag     1080

ctggtctcca agcagtgtct ccaagtccct gaacctgtga cacctgcccc aggcatcatc     1140

aggcacagag ggccaccctg cagctcagcc tactacttgc tttccaggct gttcctagtt     1200

cccatgtcag ctgcttgtgc tttccagaga caaaacagga ataatagatg tcattaaata     1260

tacattgggc cccaggcggt caatgtggca gcctgagcct cctttccatc tctgtggagg     1320

cagacatagg acccccaaca aacagcatgc aggttgggag ccagccacag gacccaggta     1380

aggggccctg ggtccttaag cttctgccac tggctccggc attgcagaga gaagagaagg     1440

ggcggcagag ctgaacctta gccttgcctt cctgggtacc cttctgagcc tcactgtctt     1500

ctgtgagatg ggcaaagtgc gggtgtgact ccttggcaac ggtgttacac cagggcaggt     1560

aaagttgtag ttatttgtgg ggtacaccag gactgttaaa ggtgtaacta t              1611


<210>  38
<211>  965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
ctgcagctca gcctactact tgctttccag gctgttccta gttcccatgt cagctgcttg       60

tgctttccag agacaaaaca ggaataatag atgtcattaa atatacattg ggccccaggc      120

ggtcaatgtg gcagcctgag cctcctttcc atctctgtgg aggcagacat aggaccccca      180

acaaacagca tgcaggttgg gagccagcca caggacccag gtaaggggcc ctgggtcctt      240

aagcttctgc cactggctcc ggcattgcag agagaagaga aggggcggca gactggagag      300

ctgggctcca tttttgttcc ttggtgccct gcccctcccc atgacctgca gagacattca      360

gcctgccagg ctttatgagg tgggagctgg gctctccctg atgtattatt cagctccctg      420

gagttggcca gctcctgtta cactggccac agccctgggc atccgcttct cacttctagt      480

ttcccctcca aggtaatgtg gtgggtcatg atcattctat cctggcttca gggacctgac      540

tccactttgg ggccattcga ggggtctagg gtagatgatg tccccctgtg gggattaatg      600

tcctgctctg taaaactgag ctagctgaga tccaggaggg cttggccaga gacagcaagt      660

tgttgccatg gtgactttaa agccaggttg ctgccccagc acaggcctcc cagtctaccc      720

tcactagaaa acaacaccca ggcactttcc accacctctc aaaggtgaaa cccaaggctg      780

gtctagagaa tgaattatgg atcctcgctg tccgtgccac ccagctagtc ccagcggctc      840

agacactgag gagagactgt aggttcagct acaagcaaaa agacctagct ggtctccaag      900

cagtgtctcc aagtccctga acctgtgaca cctgccccag gcatcatcag gcacagaggg      960

ccacc                                                                  965


<210>  39
<211>  520
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39
ctgcagctca gcctactact tgctttccag gctgttccta gttcccatgt cagctgcttg       60

tgctttccag agacaaaaca ggaataatag atgtcattaa atatacattg ggccccaggc      120

ggtcaatgtg gcagcctgag cctcctttcc atctctgtgg aggcagacat aggaccccca      180

acaaacagca tgcaggttgg gagccagcca caggacccag gtaaggggcc ctgggtcctt      240

tttatgaggt gggagctggg ctctccctga tgtattattc agctccctgg agttggccag      300

ctcctgttac actggccaca gccctgggca tccgctgcca tggtgacttt aaagccaggt      360

tgctgcccca gcacaggcct cccagtctac cctcactaga aaacaacacc caggcacttt      420

ccaccacctc tcaaaggtga aacccaaggc tggtctagag aatgaattat ggatcctcgc      480

tgtccgtgcc acccagctag tcccagcggc tcagacactg                            520


<210>  40
<211>  235
<212>  DNA
<213>  Homo sapiens

<400>  40
gtatgccttt tgagatggat gcagcaggtt ctgtgaggct gccaggaggg gtagagttcc       60

cgggggcctc gggccccgct ggagtgtgga gcaggcccat gctcagctct ccaggctgtt      120

cgtggctccc ctgtcagctg ctcactcctt tccagagaca aaacaggaat aatagacatc      180

attaaatata catagggccc caggcggtcg gcgtggtggg ctgggcctcc cttcc           235


<210>  41
<211>  688
<212>  DNA
<213>  Homo sapiens

<400>  41
tgccctgcct tctgagccgg cagcctggct ccccacccca tgtattattc agctcctgag       60

agccagccag ctcctgttac actgaccgca gcccagcacc tgctctgccc attcccctcc      120

tcccttgcct aggacctaga gggttcaaag ttctcctcca agatgacttg gtgggctttg      180

gccatcccac cctaggcccc acttctggcc cagtgcaggt gtgctggtga tttagggcag      240

gtggcattcc atctctgtgg ctcaatgtct tcctctgtga agccgaagtg acccaagggc      300

tcccttcatg gggttgagcc agctgtggcc cagggagggc ctaaccagga tgagcactga      360

tgttgccatg acgactccga ggccagaatg tctcccccag cacaggcctc ataggcaggc      420

ttccccatcc tggtaaacaa cacccacaca ctttctacta ctgctctagg gtgaaaccca      480

aggcgctcta gaggagatga attatggatc cgccctcccg gaatcctggc tcggccctcc      540

ccacgccacc cagggccagt cgggtctgct cacagcccga ggaggccgcg tgtccagccg      600

cgggcaagag acagagcagg tccctgtgtc tccaagtccc tgagcccgtg acaccggccc      660

caggccctgt agagagcagg cagccacc                                         688


<210>  42
<211>  77
<212>  DNA
<213>  Homo sapiens

<400>  42
cccctgtcag ctgctcactc ctttccagag acaaaacagg aataatagac atcattaaat       60

atacataggg ccccagg                                                      77


<210>  43
<211>  82
<212>  DNA
<213>  Homo sapiens

<400>  43
tgagccggca gcctggctcc ccaccccatg tattattcag ctcctgagag ccagccagct       60

cctgttacac tgaccgcagc cc                                                82


<210>  44
<211>  111
<212>  DNA
<213>  Homo sapiens

<400>  44
cacaggcctc ataggcaggc ttccccatcc tggtaaacaa cacccacaca ctttctacta       60

ctgctctagg gtgaaaccca aggcgctcta gaggagatga attatggatc c               111


<210>  45
<211>  193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45
tgagccggca gcctggctcc ccaccccatg tattattcag ctcctgagag ccagccagct       60

cctgttacac tgaccgcagc cccacaggcc tcataggcag gcttccccat cctggtaaac      120

aacacccaca cactttctac tactgctcta gggtgaaacc caaggcgctc tagaggagat      180

gaattatgga tcc                                                         193


<210>  46
<211>  193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
cacaggcctc ataggcaggc ttccccatcc tggtaaacaa cacccacaca ctttctacta       60

ctgctctagg gtgaaaccca aggcgctcta gaggagatga attatggatc ctgagccggc      120

agcctggctc cccaccccat gtattattca gctcctgaga gccagccagc tcctgttaca      180

ctgaccgcag ccc                                                         193


<210>  47
<211>  499
<212>  DNA
<213>  Homo sapiens

<400>  47
tgagccggca gcctggctcc ccaccccatg tattattcag ctcctgagag ccagccagct       60

cctgttacac tgaccgcagc ccagcacctg ctctgcccat tcccctcctc ccttgcctag      120

gacctagagg gttcaaagtt ctcctccaag atgacttggt gggctttggc catcccaccc      180

taggccccac ttctggccca gtgcaggtgt gctggtgatt tagggcaggt ggcattccat      240

ctctgtggct caatgtcttc ctctgtgaag ccgaagtgac ccaagggctc ccttcatggg      300

gttgagccag ctgtggccca gggagggcct aaccaggatg agcactgatg ttgccatgac      360

gactccgagg ccagaatgtc tcccccagca caggcctcat aggcaggctt ccccatcctg      420

gtaaacaaca cccacacact ttctactact gctctagggt gaaacccaag gcgctctaga      480

ggagatgaat tatggatcc                                                   499


<210>  48
<211>  1262
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48
gtatgccttt tgagatggat gcagcaggtt ctgtgaggct gccaggaggg gtagagttcc       60

cgggggcctc gggccccgct ggagtgtgga gcaggcccat gctcagctct ccaggctgtt      120

cgtggctccc ctgtcagctg ctcactcctt tccagagaca aaacaggaat aatagacatc      180

attaaatata catagggccc caggcggtcg gcgtggtggg ctgggcctcc cttccccata      240

acactgagct gctctgctgg gccaaccgtg ctcctgggcc agccagagga cccccatgag      300

gcggcatgca ggcggggagc aggccacaga acgcaggtaa ggagacctta gcctagagtc      360

cttggggtct gtcactggcc accctcgcat cccaggctgc aggaaactga ggcccagaga      420

ggacaaggac tttcctggac ccacacagcc agtcagtgac agagcctagg gtctgagcca      480

ggcctgaccc aacctccatt tctgcctctc tacccctgcc cccgccccaa cacacacaca      540

cacacaagtg gagttccact gaaacgcccc tccttgccct gccttctgag ccggcagcct      600

ggctccccac cccatgtatt attcagctcc tgagagccag ccagctcctg ttacactgac      660

cgcagcccag cacctgctct gcccattccc ctcctccctt gcctaggacc tagagggttc      720

aaagttctcc tccaagatga cttggtgggc tttggccatc ccaccctagg ccccacttct      780

ggcccagtgc aggtgtgctg gtgatttagg gcaggtggca ttccatctct gtggctcaat      840

gtcttcctct gtgaagccga agtgacccaa gggctccctt catggggttg agccagctgt      900

ggcccaggga gggcctaacc aggatgagca ctgatgttgc catgacgact ccgaggccag      960

aatgtctccc ccagcacagg cctcataggc aggcttcccc atcctggtaa acaacaccca     1020

cacactttct actactgctc tagggtgaaa cccaaggcgc tctagaggag atgaattatg     1080

gatccgccct cccggaatcc tggctcggcc ctccccacgc cacccagggc cagtcgggtc     1140

tgctcacagc ccgaggaggc cgcgtgtcca gccgcgggca agagacagag caggtccctg     1200

tgtctccaag tccctgagcc cgtgacaccg gccccaggcc ctgtagagag caggcagcca     1260

cc                                                                    1262


<210>  49
<211>  649
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49
gcaggcccat gctcagctct ccaggctgtt cgtggctccc ctgtcagctg ctcactcctt       60

tccagagaca aaacaggaat aatagacatc attaaatata catagggccc caggcggtcg      120

gcgtggtggg ctgggcctcc cttccccata acactgagct gctctgctgg gccaaccgtg      180

ctcctgggcc agccagagga cccccatgag gcggcatgca ggcggggagc aggccacaga      240

acgcaggtaa ggagaccttg ccttctgagc cggcagcctg gctccccacc ccatgtatta      300

ttcagctcct gagagccagc cagctcctgt tacactgacc gcagcccagc acctgctctg      360

cccattcccc tcctcccttg cctaggacct agagggttca aagttctcct ccaagatgac      420

ttggtgggct ttggccatcg ggcctaacca ggatgagcac tgatgttgcc atgacgactc      480

cgaggccaga atgtctcccc cagcacaggc ctcataggca ggcttcccca tcctggtaaa      540

caacacccac acactttcta ctactgctct agggtgaaac ccaaggcgct ctagaggaga      600

tgaattatgg atccgccctc ccggaatcct ggctcggccc tccccacgc                  649


<210>  50
<211>  240
<212>  DNA
<213>  Mus musculus

<400>  50
ctgcagctca gcctactact tgctttccag gctgttccta gttcccatgt cagctgcttg       60

tgctttccag agacaaaaca ggaataatag atgtcattaa atatacattg ggccccaggc      120

ggtcaatgtg gcagcctgag cctcctttcc atctctgtgg aggcagacat aggaccccca      180

acaaacagca tgcaggttgg gagccagcca caggacccag gtaaggggcc ctgggtcctt      240


<210>  51
<211>  95
<212>  DNA
<213>  Mus musculus

<400>  51
tttatgaggt gggagctggg ctctccctga tgtattattc agctccctgg agttggccag       60

ctcctgttac actggccaca gccctgggca tccgc                                  95


<210>  52
<211>  185
<212>  DNA
<213>  Mus musculus

<400>  52
tgccatggtg actttaaagc caggttgctg ccccagcaca ggcctcccag tctaccctca       60

ctagaaaaca acacccaggc actttccacc acctctcaaa ggtgaaaccc aaggctggtc      120

tagagaatga attatggatc ctcgctgtcc gtgccaccca gctagtccca gcggctcaga      180

cactg                                                                  185


<210>  53
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53
ctgcagctca gcctactact tgctttccag gctgttccta gttcccatgt cagctgcttg       60

tgctttccag agacaaaaca ggaataatag atgtcattaa atatacattg ggccccaggc      120

ggtcaatgtg gcagcctgag cctcctttcc atctctgtgg aggcagacat aggaccccca      180

acaaacagca tgcaggttgg gagccagcca caggacccag gtaaggggcc ctgggtcctt      240

tttatgaggt gggagctggg ctctccctga tgtattattc agctccctgg agttggccag      300

ctcctgttac actggccaca gccctgggca tccgc                                 335


<210>  54
<211>  425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54
ctgcagctca gcctactact tgctttccag gctgttccta gttcccatgt cagctgcttg       60

tgctttccag agacaaaaca ggaataatag atgtcattaa atatacattg ggccccaggc      120

ggtcaatgtg gcagcctgag cctcctttcc atctctgtgg aggcagacat aggaccccca      180

acaaacagca tgcaggttgg gagccagcca caggacccag gtaaggggcc ctgggtcctt      240

tgccatggtg actttaaagc caggttgctg ccccagcaca ggcctcccag tctaccctca      300

ctagaaaaca acacccaggc actttccacc acctctcaaa ggtgaaaccc aaggctggtc      360

tagagaatga attatggatc ctcgctgtcc gtgccaccca gctagtccca gcggctcaga      420

cactg                                                                  425


<210>  55
<211>  280
<212>  DNA
<213>  Mus musculus

<400>  55
tttatgaggt gggagctggg ctctccctga tgtattattc agctccctgg agttggccag       60

ctcctgttac actggccaca gccctgggca tccgctgcca tggtgacttt aaagccaggt      120

tgctgcccca gcacaggcct cccagtctac cctcactaga aaacaacacc caggcacttt      180

ccaccacctc tcaaaggtga aacccaaggc tggtctagag aatgaattat ggatcctcgc      240

tgtccgtgcc acccagctag tcccagcggc tcagacactg                            280


<210>  56
<211>  520
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56
tttatgaggt gggagctggg ctctccctga tgtattattc agctccctgg agttggccag       60

ctcctgttac actggccaca gccctgggca tccgcctgca gctcagccta ctacttgctt      120

tccaggctgt tcctagttcc catgtcagct gcttgtgctt tccagagaca aaacaggaat      180

aatagatgtc attaaatata cattgggccc caggcggtca atgtggcagc ctgagcctcc      240

tttccatctc tgtggaggca gacataggac ccccaacaaa cagcatgcag gttgggagcc      300

agccacagga cccaggtaag gggccctggg tcctttgcca tggtgacttt aaagccaggt      360

tgctgcccca gcacaggcct cccagtctac cctcactaga aaacaacacc caggcacttt      420

ccaccacctc tcaaaggtga aacccaaggc tggtctagag aatgaattat ggatcctcgc      480

tgtccgtgcc acccagctag tcccagcggc tcagacactg                            520


<210>  57
<211>  520
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57
tgccatggtg actttaaagc caggttgctg ccccagcaca ggcctcccag tctaccctca       60

ctagaaaaca acacccaggc actttccacc acctctcaaa ggtgaaaccc aaggctggtc      120

tagagaatga attatggatc ctcgctgtcc gtgccaccca gctagtccca gcggctcaga      180

cactgctgca gctcagccta ctacttgctt tccaggctgt tcctagttcc catgtcagct      240

gcttgtgctt tccagagaca aaacaggaat aatagatgtc attaaatata cattgggccc      300

caggcggtca atgtggcagc ctgagcctcc tttccatctc tgtggaggca gacataggac      360

ccccaacaaa cagcatgcag gttgggagcc agccacagga cccaggtaag gggccctggg      420

tcctttttat gaggtgggag ctgggctctc cctgatgtat tattcagctc cctggagttg      480

gccagctcct gttacactgg ccacagccct gggcatccgc                            520


<210>  58
<211>  520
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58
tttatgaggt gggagctggg ctctccctga tgtattattc agctccctgg agttggccag       60

ctcctgttac actggccaca gccctgggca tccgctgcca tggtgacttt aaagccaggt      120

tgctgcccca gcacaggcct cccagtctac cctcactaga aaacaacacc caggcacttt      180

ccaccacctc tcaaaggtga aacccaaggc tggtctagag aatgaattat ggatcctcgc      240

tgtccgtgcc acccagctag tcccagcggc tcagacactg ctgcagctca gcctactact      300

tgctttccag gctgttccta gttcccatgt cagctgcttg tgctttccag agacaaaaca      360

ggaataatag atgtcattaa atatacattg ggccccaggc ggtcaatgtg gcagcctgag      420

cctcctttcc atctctgtgg aggcagacat aggaccccca acaaacagca tgcaggttgg      480

gagccagcca caggacccag gtaaggggcc ctgggtcctt                            520


<210>  59
<211>  964
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59
tgcagctcag cctactactt gctttccagg ctgttcctag ttcccatgtc agctgcttgt       60

gctttccaga gacaaaacag gaataataga tgtcattaaa tatacattgg gccccaggcg      120

gtcaatgtgg cagcctgagc ctcctttcca tctctgtgga ggcagacata ggacccccaa      180

caaacagcat gcaggttggg agccagccac aggacccagg taaggggccc tgggtcctta      240

agcttctgcc actggctccg gcattgcaga gagaagagaa ggggcggcag actggagagc      300

tgggctccat ttttgttcct tggtgccctg cccctcccca tgacctgcag agacattcag      360

cctgccaggc tttatgaggt gggagctggg ctctccctga tgtattattc agctccctgg      420

agttggccag ctcctgttac actggccaca gccctgggca tccgcttctc acttctagtt      480

tcccctccaa ggtaatgtgg tgggtcatga tcattctatc ctggcttcag ggacctgact      540

ccactttggg gccattcgag gggtctaggg tagatgatgt ccccctgtgg ggattaatgt      600

cctgctctgt aaaactgagc tagctgagat ccaggagggc ttggccagag acagcaagtt      660

gttgccatgg tgactttaaa gccaggttgc tgccccagca caggcctccc agtctaccct      720

cactagaaaa caacacccag gcactttcca ccacctctca aaggtgaaac ccaaggctgg      780

tctagagaat gaattatgga tcctcgctgt ccgtgccacc cagctagtcc cagcggctca      840

gacactgagg agagactgta ggttcagcta caagcaaaaa gacctagctg gtctccaagc      900

agtgtctcca agtccctgaa cctgtgacac ctgccccagg catcatcagg cacagagggc      960

cacc                                                                   964


<210>  60
<211>  519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60
tgcagctcag cctactactt gctttccagg ctgttcctag ttcccatgtc agctgcttgt       60

gctttccaga gacaaaacag gaataataga tgtcattaaa tatacattgg gccccaggcg      120

gtcaatgtgg cagcctgagc ctcctttcca tctctgtgga ggcagacata ggacccccaa      180

caaacagcat gcaggttggg agccagccac aggacccagg taaggggccc tgggtccttt      240

ttatgaggtg ggagctgggc tctccctgat gtattattca gctccctgga gttggccagc      300

tcctgttaca ctggccacag ccctgggcat ccgctgccat ggtgacttta aagccaggtt      360

gctgccccag cacaggcctc ccagtctacc ctcactagaa aacaacaccc aggcactttc      420

caccacctct caaaggtgaa acccaaggct ggtctagaga atgaattatg gatcctcgct      480

gtccgtgcca cccagctagt cccagcggct cagacactg                             519


<210>  61
<211>  425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc      180

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc      240

gtggtgttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat ctagctttat      300

ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt      360

taacaacaac aattgcattc attttatgtt tcaggttcag ggggagatgt gggaggtttt      420

ttaaa                                                                  425


<210>  62
<211>  865
<212>  DNA
<213>  Homo sapiens

<400>  62
ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg       60

ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg      120

aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc      180

ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt      240

aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttccgt ataggaggac      300

cgtgtaggcc ttcctgtccc gggccttgcc agcggccagc ccgatgaagg agctccctcg      360

cagggggtag cctccgaagg agaagacgtg ggagtggtcg gcagtgacga ggctcagcgt      420

gtcctcctcg ctggtgagct ggcccgccct ctcaatggcg tcgtcgaaca tgatcgtctc      480

agtcagtgcc cggtaagccc tgctttcatg atgaccatgg tcgatgcgac caccctccac      540

gaagaggaag aagccgcggg ggtgtctgct cagcaggcgc agggcagcct ctgtcatctc      600

catcagggag gggtccagtg tggagtctcg gtggatctcg tatttcatgt ctccaggctc      660

aaagagaccc atgagatggg tcacagacgg gtccagggaa gcctgcatga gctcagtgcg      720

gttccacacg taccgggcac cctggcgttc gccgagccat tcctgcacca gattcttccc      780

gtccagcctg gtcccacctt ggctgtagtc atctgggtac tcagggtctg gggttcccat      840

gcgaaacatg tactttcggc ctcca                                            865


<210>  63
<211>  437
<212>  DNA
<213>  Homo sapiens

<400>  63
ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg       60

ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg      120

aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc      180

ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt      240

aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttccgt ataggaggac      300

cgtgtaggcc ttcctgtccc gggccttgcc agcggccagc ccgatgaagg agctccctcg      360

cagggggtag cctccgaagg agaagacgtg ggagtggtcg gcagtgacga ggctcagcgt      420

gtcctcctcg ctggtga                                                     437


<210>  64
<211>  428
<212>  DNA
<213>  Homo sapiens

<400>  64
gctggcccgc cctctcaatg gcgtcgtcga acatgatcgt ctcagtcagt gcccggtaag       60

ccctgctttc atgatgacca tggtcgatgc gaccaccctc cacgaagagg aagaagccgc      120

gggggtgtct gctcagcagg cgcagggcag cctctgtcat ctccatcagg gaggggtcca      180

gtgtggagtc tcggtggatc tcgtatttca tgtctccagg ctcaaagaga cccatgagat      240

gggtcacaga cgggtccagg gaagcctgca tgagctcagt gcggttccac acgtaccggg      300

caccctggcg ttcgccgagc cattcctgca ccagattctt cccgtccagc ctggtcccac      360

cttggctgta gtcatctggg tactcagggt ctggggttcc catgcgaaac atgtactttc      420

ggcctcca                                                               428


<210>  65
<211>  287
<212>  DNA
<213>  Homo sapiens

<400>  65
ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg       60

ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg      120

aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc      180

ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt      240

aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttc                    287


<210>  66
<211>  290
<212>  DNA
<213>  Homo sapiens

<400>  66
cgtataggag gaccgtgtag gccttcctgt cccgggcctt gccagcggcc agcccgatga       60

aggagctccc tcgcaggggg tagcctccga aggagaagac gtgggagtgg tcggcagtga      120

cgaggctcag cgtgtcctcc tcgctggtga gctggcccgc cctctcaatg gcgtcgtcga      180

acatgatcgt ctcagtcagt gcccggtaag ccctgctttc atgatgacca tggtcgatgc      240

gaccaccctc cacgaagagg aagaagccgc gggggtgtct gctcagcagg                 290


<210>  67
<211>  288
<212>  DNA
<213>  Homo sapiens

<400>  67
cgcagggcag cctctgtcat ctccatcagg gaggggtcca gtgtggagtc tcggtggatc       60

tcgtatttca tgtctccagg ctcaaagaga cccatgagat gggtcacaga cgggtccagg      120

gaagcctgca tgagctcagt gcggttccac acgtaccggg caccctggcg ttcgccgagc      180

cattcctgca ccagattctt cccgtccagc ctggtcccac cttggctgta gtcatctggg      240

tactcagggt ctggggttcc catgcgaaac atgtactttc ggcctcca                   288


<210>  68
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctga                                              84


<210>  69
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69
taggcaccta ttggtcttac tgacatccac tttgcctttc tctccacag                   49


