
				SEQUENCE LISTING

<110> Krystal Biotech, Inc.
      PARRY, Trevor
      KRISHNAN, Suma
      KRISHNAN, Krish
      AGARWAL, Pooja

<120> COMPOSITIONS AND METHODS FOR DELIVERING
  CFTR POLYPEPTIDES
  

<130> 761342001140

<140> Not Yet Assigned    
<141> Concurrently Herewith      

<150> US 62/802,871
<151> 2019-02-08   

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4443
<212> DNA
<213> Homo sapiens

<400> 1
atgcagaggt cgcctctgga aaaggccagc gttgtctcca aacttttttt cagctggacc 60
agaccaattt tgaggaaagg atacagacag cgcctggaat tgtcagacat ataccaaatc 120
ccttctgttg attctgctga caatctatct gaaaaattgg aaagagaatg ggatagagag 180
ctggcttcaa agaaaaatcc taaactcatt aatgcccttc ggcgatgttt tttctggaga 240
tttatgttct atggaatctt tttatattta ggggaagtca ccaaagcagt acagcctctc 300
ttactgggaa gaatcatagc ttcctatgac ccggataaca aggaggaacg ctctatcgcg 360
atttatctag gcataggctt atgccttctc tttattgtga ggacactgct cctacaccca 420
gccatttttg gccttcatca cattggaatg cagatgagaa tagctatgtt tagtttgatt 480
tataagaaga ctttaaagct gtcaagccgt gttctagata aaataagtat tggacaactt 540
gttagtctcc tttccaacaa cctgaacaaa tttgatgaag gacttgcatt ggcacatttc 600
gtgtggatcg ctcctttgca agtggcactc ctcatggggc taatctggga gttgttacag 660
gcgtctgcct tctgtggact tggtttcctg atagtccttg ccctttttca ggctgggcta 720
gggagaatga tgatgaagta cagagatcag agagctggga agatcagtga aagacttgtg 780
attacctcag aaatgattga aaatatccaa tctgttaagg catactgctg ggaagaagca 840
atggaaaaaa tgattgaaaa cttaagacaa acagaactga aactgactcg gaaggcagcc 900
tatgtgagat acttcaatag ctcagccttc ttcttctcag ggttctttgt ggtgttttta 960
tctgtgcttc cctatgcact aatcaaagga atcatcctcc ggaaaatatt caccaccatc 1020
tcattctgca ttgttctgcg catggcggtc actcggcaat ttccctgggc tgtacaaaca 1080
tggtatgact ctcttggagc aataaacaaa atacaggatt tcttacaaaa gcaagaatat 1140
aagacattgg aatataactt aacgactaca gaagtagtga tggagaatgt aacagccttc 1200
tgggaggagg gatttgggga attatttgag aaagcaaaac aaaacaataa caatagaaaa 1260
acttctaatg gtgatgacag cctcttcttc agtaatttct cacttcttgg tactcctgtc 1320
ctgaaagata ttaatttcaa gatagaaaga ggacagttgt tggcggttgc tggatccact 1380
ggagcaggca agacttcact tctaatggtg attatgggag aactggagcc ttcagagggt 1440
aaaattaagc acagtggaag aatttcattc tgttctcagt tttcctggat tatgcctggc 1500
accattaaag aaaatatcat ctttggtgtt tcctatgatg aatatagata cagaagcgtc 1560
atcaaagcat gccaactaga agaggacatc tccaagtttg cagagaaaga caatatagtt 1620
cttggagaag gtggaatcac actgagtgga ggtcaacgag caagaatttc tttagcaaga 1680
gcagtataca aagatgctga tttgtattta ttagactctc cttttggata cctagatgtt 1740
ttaacagaaa aagaaatatt tgaaagctgt gtctgtaaac tgatggctaa caaaactagg 1800
attttggtca cttctaaaat ggaacattta aagaaagctg acaaaatatt aattttgcat 1860
gaaggtagca gctattttta tgggacattt tcagaactcc aaaatctaca gccagacttt 1920
agctcaaaac tcatgggatg tgattctttc gaccaattta gtgcagaaag aagaaattca 1980
atcctaactg agaccttaca ccgtttctca ttagaaggag atgctcctgt ctcctggaca 2040
gaaacaaaaa aacaatcttt taaacagact ggagagtttg gggaaaaaag gaagaattct 2100
attctcaatc caatcaactc tatacgaaaa ttttccattg tgcaaaagac tcccttacaa 2160
atgaatggca tcgaagagga ttctgatgag cctttagaga gaaggctgtc cttagtacca 2220
gattctgagc agggagaggc gatactgcct cgcatcagcg tgatcagcac tggccccacg 2280
cttcaggcac gaaggaggca gtctgtcctg aacctgatga cacactcagt taaccaaggt 2340
cagaacattc accgaaagac aacagcatcc acacgaaaag tgtcactggc ccctcaggca 2400
aacttgactg aactggatat atattcaaga aggttatctc aagaaactgg cttggaaata 2460
agtgaagaaa ttaacgaaga agacttaaag gagtgctttt ttgatgatat ggagagcata 2520
ccagcagtga ctacatggaa cacatacctt cgatatatta ctgtccacaa gagcttaatt 2580
tttgtgctaa tttggtgctt agtaattttt ctggcagagg tggctgcttc tttggttgtg 2640
ctgtggctcc ttggaaacac tcctcttcaa gacaaaggga atagtactca tagtagaaat 2700
aacagctatg cagtgattat caccagcacc agttcgtatt atgtgtttta catttacgtg 2760
ggagtagccg acactttgct tgctatggga ttcttcagag gtctaccact ggtgcatact 2820
ctaatcacag tgtcgaaaat tttacaccac aaaatgttac attctgttct tcaagcacct 2880
atgtcaaccc tcaacacgtt gaaagcaggt gggattctta atagattctc caaagatata 2940
gcaattttgg atgaccttct gcctcttacc atatttgact tcatccagtt gttattaatt 3000
gtgattggag ctatagcagt tgtcgcagtt ttacaaccct acatctttgt tgcaacagtg 3060
ccagtgatag tggcttttat tatgttgaga gcatatttcc tccaaacctc acagcaactc 3120
aaacaactgg aatctgaagg caggagtcca attttcactc atcttgttac aagcttaaaa 3180
ggactatgga cacttcgtgc cttcggacgg cagccttact ttgaaactct gttccacaaa 3240
gctctgaatt tacatactgc caactggttc ttgtacctgt caacactgcg ctggttccaa 3300
atgagaatag aaatgatttt tgtcatcttc ttcattgctg ttaccttcat ttccatttta 3360
acaacaggag aaggagaagg aagagttggt attatcctga ctttagccat gaatatcatg 3420
agtacattgc agtgggctgt aaactccagc atagatgtgg atagcttgat gcgatctgtg 3480
agccgagtct ttaagttcat tgacatgcca acagaaggta aacctaccaa gtcaaccaaa 3540
ccatacaaga atggccaact ctcgaaagtt atgattattg agaattcaca cgtgaagaaa 3600
gatgacatct ggccctcagg gggccaaatg actgtcaaag atctcacagc aaaatacaca 3660
gaaggtggaa atgccatatt agagaacatt tccttctcaa taagtcctgg ccagagggtg 3720
ggcctcttgg gaagaactgg atcagggaag agtactttgt tatcagcttt tttgagacta 3780
ctgaacactg aaggagaaat ccagatcgat ggtgtgtctt gggattcaat aactttgcaa 3840
cagtggagga aagcctttgg agtgatacca cagaaagtat ttattttttc tggaacattt 3900
agaaaaaact tggatcccta tgaacagtgg agtgatcaag aaatatggaa agttgcagat 3960
gaggttgggc tcagatctgt gatagaacag tttcctggga agcttgactt tgtccttgtg 4020
gatgggggct gtgtcctaag ccatggccac aagcagttga tgtgcttggc tagatctgtt 4080
ctcagtaagg cgaagatctt gctgcttgat gaacccagtg ctcatttgga tccagtaaca 4140
taccaaataa ttagaagaac tctaaaacaa gcatttgctg attgcacagt aattctctgt 4200
gaacacagga tagaagcaat gctggaatgc caacaatttt tggtcataga agagaacaaa 4260
gtgcggcagt acgattccat ccagaaactg ctgaacgaga ggagcctctt ccggcaagcc 4320
atcagcccct ccgacagggt gaagctcttt ccccaccgga actcaagcaa gtgcaagtct 4380
aagccccaga ttgctgctct gaaagaggag acagaagaag aggtgcaaga tacaaggctt 4440
tag                                                               4443
 
<210> 2
<211> 4443
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
atgcagagaa gccctctgga aaaggccagc gtggtgtcca agctgttctt cagctggacc 60
cggcctatcc tgcggaaggg ctatagacag agactggaac tgagcgacat ctatcagatc 120
cccagcgtgg acagcgccga caacctgtct gagaagctgg aaagagagtg ggacagagag 180
ctggcctcca agaagaaccc caagctgatc aacgccctgc ggcggtgctt cttctggcgg 240
tttatgttct acggcatctt cctgtacctg ggcgaagtga ccaaagccgt gcagcctctg 300
ctgctgggca gaatcattgc cagctacgac cccgacaaca aagaggaacg gtctatcgcc 360
atctacctcg gcatcggcct gtgcctgctg tttatcgtca gaaccctgct gctgcacccc 420
gccatctttg gactgcacca catcggcatg cagatgcgga tcgccatgtt cagcctgatc 480
tacaagaaaa ccctgaagct gtccagcaga gtgctggaca agatcagcat cggacagctg 540
gtgtccctgc tgagcaacaa cctgaacaag ttcgacgaag gcctggctct ggcccacttc 600
gtgtggattg ctcctctgca agtggccctg ctgatgggcc tgatttggga actgctgcag 660
gccagcgcct tttgcggact gggatttctg attgtgctgg ccctgttcca ggccggactg 720
gggagaatga tgatgaagta ccgggaccag agagccggca agatctccga gagactggtc 780
atcaccagcg agatgatcga gaacatccag agcgtgaagg cctactgctg ggaagaggcc 840
atggaaaaga tgattgagaa tctgcggcag accgagctga agctgacaag aaaggccgcc 900
tacgtgcgct acttcaacag cagcgccttc ttcttctccg gcttcttcgt ggtgttcctg 960
agcgtgctgc cctacgctct gatcaagggc atcatcctga gaaagatttt caccaccatt 1020
tctttctgca tcgtgctgcg gatggccgtg accagacagt ttccttgggc tgtgcagact 1080
tggtacgata gcctgggcgc catcaacaag atccaggact tcctgcagaa gcaagagtac 1140
aagaccctcg agtacaacct gaccaccacc gaggtggtca tggaaaacgt gaccgccttc 1200
tgggaggaag gcttcggcga gctgtttgag aaggccaagc agaacaacaa caaccgcaag 1260
accagcaacg gcgacgacag cctgttcttc tccaacttct ccctgctggg gacccctgtg 1320
ctgaaggaca tcaacttcaa gatcgagcgg ggacagctgc tggccgtggc tggatctaca 1380
ggcgccggaa aaaccagcct gctcatggtc atcatgggcg agctggaacc tagcgagggc 1440
aagatcaagc acagcggcag gatcagcttc tgtagccagt tctcctggat catgcccggc 1500
accatcaaag agaacatcat cttcggcgtg tcctacgacg agtacagata ccgcagcgtg 1560
atcaaggcct gccagctgga agaggacatc agcaagttcg ccgagaagga caacatcgtg 1620
ctcggcgaag gcggcatcac actgtctggc ggacagaggg ccagaatctc tctggctaga 1680
gccgtgtaca aggacgccga tctgtacctg ctggatagcc ccttcggcta cctggatgtg 1740
ctgaccgaga aagagatctt cgagagctgc gtgtgcaagc tgatggccaa caagaccaga 1800
atcctggtca cctccaagat ggaacacctg aagaaggccg acaagatcct gattctgcac 1860
gagggcagca gctactttta cggcaccttc agcgagctgc agaacctgca gcctgacttc 1920
agcagcaaac tgatgggctg cgactccttc gaccagttca gcgccgagcg gagaaacagc 1980
atcctgacag agacactgca ccggttctcc ctggaaggcg acgctcctgt gtcttggacc 2040
gagacaaaga agcagagctt caagcagacc ggcgagtttg gcgagaagcg gaagaactcc 2100
attctgaacc ccatcaactc catccggaag ttcagcatcg tccagaaaac ccctctgcag 2160
atgaacggca tcgaagagga tagcgacgag cccctggaaa gacggctgtc tctggtgcct 2220
gatagcgaac agggcgaagc catcctgcct cggatctccg tgattagcac aggccctaca 2280
ctgcaggctc ggagaaggca gagtgtgctg aacctgatga cccacagcgt gaaccaggga 2340
cagaatatcc acagaaagac caccgccagc acacggaaag tgtcactggc ccctcaggcc 2400
aacctgactg agctggacat ctacagcaga cggctgagcc aagagacagg cctggaaatc 2460
agcgaggaaa tcaacgaaga ggacctgaaa gagtgctttt tcgacgacat ggaatctatc 2520
cccgccgtga caacctggaa tacctacctg cggtacatca ccgtgcacaa gtccctgatc 2580
ttcgtgctga tctggtgtct cgtgatcttc ctggccgaag tggccgcttc tctggtggtt 2640
ctgtggctgc tcggaaacac cccactgcag gacaagggca atagcaccca cagccggaac 2700
aacagctacg ccgtgatcat cacctccacc agctcctact acgtgttcta catctacgtg 2760
ggcgtcgccg acactctgct cgccatgggc ttttttagag gactgcccct ggtgcacacc 2820
ctgatcaccg tgtctaagat cctgcaccat aagatgctgc acagcgtcct gcaggcccct 2880
atgagcacac tgaacaccct gaaagccggc ggaatcctga acagattcag caaggacatt 2940
gccatcctgg acgacctgct gcctctgacc atcttcgact tcatccagct gctgctgatc 3000
gtgatcggcg ccattgctgt ggtggctgtg ctgcagcctt acatcttcgt ggccaccgtg 3060
cctgtgatcg tggccttcat tatgctgcgg gcctactttc tgcagacctc tcagcagctg 3120
aagcagctcg agtctgaggg cagaagcccc atctttaccc acctcgtgac cagcctgaaa 3180
ggcctgtgga ccctgagagc ctttggcaga cagccctact tcgagacact gttccacaag 3240
gccctgaacc tgcacaccgc caactggttt ctgtatctga gcaccctgcg gtggttccag 3300
atgaggatcg agatgatttt cgtcatcttc tttatcgccg tgaccttcat cagcatcctc 3360
accactggcg aaggcgaggg cagagtggga atcattctga ccctggccat gaacatcatg 3420
tccacactcc agtgggccgt gaacagcagc atcgatgtgg acagcctgat gcggagcgtg 3480
tcccgggtgt tcaagttcat cgacatgccc acagagggca agcccaccaa gagcaccaag 3540
ccttacaaga acggccagct gagcaaagtc atgatcatcg agaactccca cgtcaagaag 3600
gacgacattt ggcccagcgg aggccagatg accgtgaagg atctgaccgc caagtacacc 3660
gaaggcggaa acgccattct ggaaaacatc agctttagca tcagccctgg ccagcgcgtg 3720
ggactccttg gaagaaccgg aagcggcaag tctactctgc tgagcgcctt cctgagactg 3780
ctgaataccg agggcgagat ccagatcgat ggggtgtcct gggacagcat caccctgcaa 3840
caatggcgga aggcctttgg cgtgatccct cagaaggtgt tcattttcag cggcacgttc 3900
cggaagaatc tggaccccta cgagcagtgg agcgaccaag agatttggaa ggtggccgat 3960
gaagtgggac tgagaagcgt gatcgagcag tttcccggca agctggattt cgtgctggtg 4020
gatggcggct gtgtgctgtc tcacggacac aagcagctga tgtgcctggc cagatccgtg 4080
ctgtccaagg ccaagattct gctgctcgac gagcctagcg ctcacctcga tcctgtgacc 4140
taccagatca tccggcggac actgaagcag gcctttgccg attgcaccgt gatcctgtgc 4200
gagcacagaa ttgaggccat gctggaatgc cagcagtttc tggttatcga agagaacaaa 4260
gtgcggcagt acgacagcat ccagaagctg ctgaacgagc ggagcctgtt cagacaggcc 4320
atctctccca gcgacagagt gaagctgttc cctcaccgga acagctccaa gtgcaagagc 4380
aagcctcaga tcgccgctct gaaagaagaa accgaggaag aggtgcagga cacacggctg 4440
taa                                                               4443

<210> 3
<211> 4260
<212> DNA
<213> Homo sapiens

<400> 3
atgcagaggt cgcctctgga aaaggccagc gttgtctcca aacttttttt cagctggacc 60
agaccaattt tgaggaaagg atacagacag cgcctggaat tgtcagacat ataccaaatc 120
ccttctgttg attctgctga caatctatct gaaaaattgg aaagagaatg ggatagagag 180
ctggcttcaa agaaaaatcc taaactcatt aatgcccttc ggcgatgttt tttctggaga 240
tttatgttct atggaatctt tttatattta ggggaagtca ccaaagcagt acagcctctc 300
ttactgggaa gaatcatagc ttcctatgac ccggataaca aggaggaacg ctctatcgcg 360
atttatctag gcataggctt atgccttctc tttattgtga ggacactgct cctacaccca 420
gccatttttg gccttcatca cattggaatg cagatgagaa tagctatgtt tagtttgatt 480
tataagaaga ctttaaagct gtcaagccgt gttctagata aaataagtat tggacaactt 540
gttagtctcc tttccaacaa cctgaacaaa tttgatgaag gacttgcatt ggcacatttc 600
gtgtggatcg ctcctttgca agtggcactc ctcatggggc taatctggga gttgttacag 660
gcgtctgcct tctgtggact tggtttcctg atagtccttg ccctttttca ggctgggcta 720
gggagaatga tgatgaagta cagagatcag agagctggga agatcagtga aagacttgtg 780
attacctcag aaatgattga aaatatccaa tctgttaagg catactgctg ggaagaagca 840
atggaaaaaa tgattgaaaa cttaagacaa acagaactga aactgactcg gaaggcagcc 900
tatgtgagat acttcaatag ctcagccttc ttcttctcag ggttctttgt ggtgttttta 960
tctgtgcttc cctatgcact aatcaaagga atcatcctcc ggaaaatatt caccaccatc 1020
tcattctgca ttgttctgcg catggcggtc actcggcaat ttccctgggc tgtacaaaca 1080
tggtatgact ctcttggagc aataaacaaa atacaggatt tcttacaaaa gcaagaatat 1140
aagacattgg aatataactt aacgactaca gaagtagtga tggagaatgt aacagccttc 1200
tgggaggaga cttcacttct aatggtgatt atgggagaac tggagccttc agagggtaaa 1260
attaagcaca gtggaagaat ttcattctgt tctcagtttt cctggattat gcctggcacc 1320
attaaagaaa atatcatctt tggtgtttcc tatgatgaat atagatacag aagcgtcatc 1380
aaagcatgcc aactagaaga ggacatctcc aagtttgcag agaaagacaa tatagttctt 1440
ggagaaggtg gaatcacact gagtggaggt caacgagcaa gaatttcttt agcaagagca 1500
gtatacaaag atgctgattt gtatttatta gactctcctt ttggatacct agatgtttta 1560
acagaaaaag aaatatttga aagctgtgtc tgtaaactga tggctaacaa aactaggatt 1620
ttggtcactt ctaaaatgga acatttaaag aaagctgaca aaatattaat tttgcatgaa 1680
ggtagcagct atttttatgg gacattttca gaactccaaa atctacagcc agactttagc 1740
tcaaaactca tgggatgtga ttctttcgac caatttagtg cagaaagaag aaattcaatc 1800
ctaactgaga ccttacaccg tttctcatta gaaggagatg ctcctgtctc ctggacagaa 1860
acaaaaaaac aatcttttaa acagactgga gagtttgggg aaaaaaggaa gaattctatt 1920
ctcaatccaa tcaactctat acgaaaattt tccattgtgc aaaagactcc cttacaaatg 1980
aatggcatcg aagaggattc tgatgagcct ttagagagaa ggctgtcctt agtaccagat 2040
tctgagcagg gagaggcgat actgcctcgc atcagcgtga tcagcactgg ccccacgctt 2100
caggcacgaa ggaggcagtc tgtcctgaac ctgatgacac actcagttaa ccaaggtcag 2160
aacattcacc gaaagacaac agcatccaca cgaaaagtgt cactggcccc tcaggcaaac 2220
ttgactgaac tggatatata ttcaagaagg ttatctcaag aaactggctt ggaaataagt 2280
gaagaaatta acgaagaaga cttaaaggag tgcttttttg atgatatgga gagcatacca 2340
gcagtgacta catggaacac ataccttcga tatattactg tccacaagag cttaattttt 2400
gtgctaattt ggtgcttagt aatttttctg gcagaggtgg ctgcttcttt ggttgtgctg 2460
tggctccttg gaaacactcc tcttcaagac aaagggaata gtactcatag tagaaataac 2520
agctatgcag tgattatcac cagcaccagt tcgtattatg tgttttacat ttacgtggga 2580
gtagccgaca ctttgcttgc tatgggattc ttcagaggtc taccactggt gcatactcta 2640
atcacagtgt cgaaaatttt acaccacaaa atgttacatt ctgttcttca agcacctatg 2700
tcaaccctca acacgttgaa agcaggtggg attcttaata gattctccaa agatatagca 2760
attttggatg accttctgcc tcttaccata tttgacttca tccagttgtt attaattgtg 2820
attggagcta tagcagttgt cgcagtttta caaccctaca tctttgttgc aacagtgcca 2880
gtgatagtgg cttttattat gttgagagca tatttcctcc aaacctcaca gcaactcaaa 2940
caactggaat ctgaaggcag gagtccaatt ttcactcatc ttgttacaag cttaaaagga 3000
ctatggacac ttcgtgcctt cggacggcag ccttactttg aaactctgtt ccacaaagct 3060
ctgaatttac atactgccaa ctggttcttg tacctgtcaa cactgcgctg gttccaaatg 3120
agaatagaaa tgatttttgt catcttcttc attgctgtta ccttcatttc cattttaaca 3180
acaggagaag gagaaggaag agttggtatt atcctgactt tagccatgaa tatcatgagt 3240
acattgcagt gggctgtaaa ctccagcata gatgtggata gcttgatgcg atctgtgagc 3300
cgagtcttta agttcattga catgccaaca gaaggtaaac ctaccaagtc aaccaaacca 3360
tacaagaatg gccaactctc gaaagttatg attattgaga attcacacgt gaagaaagat 3420
gacatctggc cctcaggggg ccaaatgact gtcaaagatc tcacagcaaa atacacagaa 3480
ggtggaaatg ccatattaga gaacatttcc ttctcaataa gtcctggcca gagggtgggc 3540
ctcttgggaa gaactggatc agggaagagt actttgttat cagctttttt gagactactg 3600
aacactgaag gagaaatcca gatcgatggt gtgtcttggg attcaataac tttgcaacag 3660
tggaggaaag cctttggagt gataccacag aaagtattta ttttttctgg aacatttaga 3720
aaaaacttgg atccctatga acagtggagt gatcaagaaa tatggaaagt tgcagatgag 3780
gttgggctca gatctgtgat agaacagttt cctgggaagc ttgactttgt ccttgtggat 3840
gggggctgtg tcctaagcca tggccacaag cagttgatgt gcttggctag atctgttctc 3900
agtaaggcga agatcttgct gcttgatgaa cccagtgctc atttggatcc agtaacatac 3960
caaataatta gaagaactct aaaacaagca tttgctgatt gcacagtaat tctctgtgaa 4020
cacaggatag aagcaatgct ggaatgccaa caatttttgg tcatagaaga gaacaaagtg 4080
cggcagtacg attccatcca gaaactgctg aacgagagga gcctcttccg gcaagccatc 4140
agcccctccg acagggtgaa gctctttccc caccggaact caagcaagtg caagtctaag 4200
ccccagattg ctgctctgaa agaggagaca gaagaagagg tgcaagatac aaggctttag 4260
         
<210> 4
<211> 4260
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
atgcagagaa gccctctgga aaaggccagc gtggtgtcca agctgttctt cagctggacc 60
cggcctatcc tgcggaaggg ctatagacag agactggaac tgagcgacat ctatcagatc 120
cccagcgtgg acagcgccga caacctgtct gagaagctgg aaagagagtg ggacagagag 180
ctggcctcca agaagaaccc caagctgatc aacgccctgc ggcggtgctt cttctggcgg 240
tttatgttct acggcatctt cctgtacctg ggcgaagtga ccaaagccgt gcagcctctg 300
ctgctgggca gaatcattgc cagctacgac cccgacaaca aagaggaacg gtctatcgcc 360
atctacctcg gcatcggcct gtgcctgctg tttatcgtca gaaccctgct gctgcacccc 420
gccatctttg gactgcacca catcggcatg cagatgcgga tcgccatgtt cagcctgatc 480
tacaagaaaa ccctgaagct gtccagcaga gtgctggaca agatcagcat cggacagctg 540
gtgtccctgc tgagcaacaa cctgaacaag ttcgacgaag gcctggctct ggcccacttc 600
gtgtggattg ctcctctgca agtggccctg ctgatgggcc tgatttggga actgctgcag 660
gccagcgcct tttgcggact gggatttctg attgtgctgg ccctgttcca ggccggactg 720
gggagaatga tgatgaagta ccgggaccag agagccggca agatctccga gagactggtc 780
atcaccagcg agatgatcga gaacatccag agcgtgaagg cctactgctg ggaagaggcc 840
atggaaaaga tgattgagaa tctgcggcag accgagctga agctgacaag aaaggccgcc 900
tacgtgcgct acttcaacag cagcgccttc ttcttctccg gcttcttcgt ggtgttcctg 960
agcgtgctgc cctacgctct gatcaagggc atcatcctga gaaagatttt caccaccatt 1020
tctttctgca tcgtgctgcg gatggccgtg accagacagt ttccttgggc tgtgcagact 1080
tggtacgata gcctgggcgc catcaacaag atccaggact tcctgcagaa gcaagagtac 1140
aagaccctcg agtacaacct gaccaccacc gaggtggtca tggaaaacgt gaccgccttc 1200
tgggaagaaa ccagcctgct catggtcatc atgggcgagc tggaacctag cgagggcaag 1260
atcaagcaca gcggcaggat cagcttctgt agccagttct cctggatcat gcccggcacc 1320
atcaaagaga acatcatctt cggcgtgtcc tacgacgagt acagataccg cagcgtgatc 1380
aaggcctgcc agctggaaga ggacatcagc aagttcgccg agaaggacaa catcgtgctc 1440
ggcgaaggcg gcatcacact gtctggcgga cagagggcca gaatctctct ggctagagcc 1500
gtgtacaagg acgccgatct gtacctgctg gatagcccct tcggctacct ggatgtgctg 1560
accgagaaag agatcttcga gagctgcgtg tgcaagctga tggccaacaa gaccagaatc 1620
ctggtcacct ccaagatgga acacctgaag aaggccgaca agatcctgat tctgcacgag 1680
ggcagcagct acttttacgg caccttcagc gagctgcaga acctgcagcc tgacttcagc 1740
agcaaactga tgggctgcga ctccttcgac cagttcagcg ccgagcggag aaacagcatc 1800
ctgacagaga cactgcaccg gttctccctg gaaggcgacg ctcctgtgtc ttggaccgag 1860
acaaagaagc agagcttcaa gcagaccggc gagtttggcg agaagcggaa gaactccatt 1920
ctgaacccca tcaactccat ccggaagttc agcatcgtcc agaaaacccc tctgcagatg 1980
aacggcatcg aagaggatag cgacgagccc ctggaaagac ggctgtctct ggtgcctgat 2040
agcgaacagg gcgaagccat cctgcctcgg atctccgtga ttagcacagg ccctacactg 2100
caggctcgga gaaggcagtc tgtgctgaac ctgatgaccc acagcgtgaa ccagggacag 2160
aatatccaca gaaagaccac cgccagcaca cggaaagtgt cactggcccc tcaggccaac 2220
ctgactgagc tggacatcta cagcagacgg ctgagccaag agacaggcct ggaaatcagc 2280
gaggaaatca acgaagagga cctgaaagag tgctttttcg acgacatgga atctatcccc 2340
gccgtgacaa cctggaatac ctacctgcgg tacatcaccg tgcacaagtc cctgatcttc 2400
gtgctgatct ggtgtctcgt gatcttcctg gccgaagtgg ccgcttctct ggtggttctg 2460
tggctgctgg ggaatacccc actgcaggac aagggcaata gcacccacag ccggaacaac 2520
agctacgccg tgatcatcac ctccaccagc tcctactacg tgttctacat ctacgtgggc 2580
gtcgccgaca ctctgctcgc catgggcttt tttagaggac tgcccctggt gcacaccctg 2640
atcaccgtgt ctaagatcct gcaccataag atgctgcaca gcgtcctgca ggcccctatg 2700
agcacactga acaccctgaa agccggcgga atcctgaaca gattcagcaa ggacattgcc 2760
atcctggacg acctgctgcc tctgaccatc ttcgacttca tccagctgct gctgatcgtg 2820
atcggcgcca ttgctgtggt ggctgtgctg cagccttaca tcttcgtggc caccgtgcct 2880
gtgatcgtgg ccttcattat gctgcgggcc tactttctgc agaccagcca gcagctgaag 2940
cagctcgagt ctgagggcag aagccccatc tttacccacc tcgtgaccag cctgaaaggc 3000
ctgtggaccc tgagagcctt tggcagacag ccctacttcg agacactgtt ccacaaggcc 3060
ctgaacctgc acaccgccaa ctggtttctg tatctgagca ccctgcggtg gttccagatg 3120
aggatcgaga tgattttcgt catcttcttt atcgccgtga ccttcatcag catcctcacc 3180
actggcgaag gcgagggcag agtgggaatc attctgaccc tggccatgaa catcatgtcc 3240
acactccagt gggccgtgaa cagcagcatc gatgtggaca gcctgatgcg gagcgtgtcc 3300
cgggtgttca agttcatcga catgcccaca gagggcaagc ccaccaagag caccaagcct 3360
tacaagaacg gccagctgag caaagtcatg atcatcgaga actcccacgt caagaaggac 3420
gacatttggc ccagcggagg ccagatgacc gtgaaggatc tgaccgccaa gtacaccgaa 3480
ggcggaaacg ccattctgga aaacatcagc tttagcatca gccctggcca gcgcgtggga 3540
ctgcttggaa gaacaggatc tggcaagtct actctgctga gcgccttcct gagactgctg 3600
aataccgagg gcgagatcca gatcgatggg gtgtcctggg acagcatcac cctgcaacaa 3660
tggcggaagg cctttggcgt gatccctcag aaggtgttca ttttcagcgg cacgttccgg 3720
aagaatctgg acccctacga gcagtggagc gaccaagaga tttggaaggt ggccgatgaa 3780
gtgggactga gaagcgtgat cgagcagttt cccggcaagc tggatttcgt gctggtggat 3840
ggcggctgtg tgctgtctca cggacacaag cagctgatgt gcctggccag aagcgtgctg 3900
tctaaggcca agatcctcct gctggacgag ccctctgctc acctcgatcc tgtgacctac 3960
cagatcatcc ggcggacact gaagcaggcc tttgccgatt gcaccgtgat cctgtgcgag 4020
cacagaatcg aggccatgct ggaatgccag cagtttctgg ttatcgaaga gaacaaagtg 4080
cggcagtacg acagcattca gaagctgctg aacgagcgga gcctgttcag acaggccatc 4140
tctcccagcg acagagtgaa gctgttccct caccggaaca gctccaagtg caagagcaag 4200
cctcagatcg ccgctctgaa agaagaaacc gaggaagagg tgcaggacac acggctgtaa 4260
 
<210> 5
<211> 1480
<212> PRT
<213> Homo sapiens

<400> 5
Met Gln Arg Ser Pro Leu Glu Lys Ala Ser Val Val Ser Lys Leu Phe 
 1               5                  10                  15  
Phe Ser Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu 
            20                  25                  30   
Glu Leu Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn 
        35                  40                  45     
Leu Ser Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys 
    50                  55                  60             
Lys Asn Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg 
65                  70                  75                  80
Phe Met Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala 
                85                  90                  95 
Val Gln Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp 
            100                 105                 110
Asn Lys Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys 
        115                 120                 125  
Leu Leu Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly 
    130                 135                 140              
Leu His His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile 
145                 150                 155                 160
Tyr Lys Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser 
                165                 170                 175 
Ile Gly Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp 
            180                 185                 190 
Glu Gly Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val 
        195                 200                 205     
Ala Leu Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe 
    210                 215                 220             
Cys Gly Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu 
225                 230                 235                 240
Gly Arg Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser 
                245                 250                 255 
Glu Arg Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val 
            260                 265                 270    
Lys Ala Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu 
        275                 280                 285        
Arg Gln Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr 
    290                 295                 300         
Phe Asn Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu 
305                 310                 315                 320
Ser Val Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile 
                325                 330                 335   
Phe Thr Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg 
            340                 345                 350     
Gln Phe Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile 
        355                 360                 365       
Asn Lys Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu 
    370                 375                 380           
Tyr Asn Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe 
385                 390                 395                 400
Trp Glu Glu Gly Phe Gly Glu Leu Phe Glu Lys Ala Lys Gln Asn Asn 
                405                 410                 415 
Asn Asn Arg Lys Thr Ser Asn Gly Asp Asp Ser Leu Phe Phe Ser Asn 
            420                 425                 430    
Phe Ser Leu Leu Gly Thr Pro Val Leu Lys Asp Ile Asn Phe Lys Ile 
        435                 440                 445    
Glu Arg Gly Gln Leu Leu Ala Val Ala Gly Ser Thr Gly Ala Gly Lys 
    450                 455                 460    
Thr Ser Leu Leu Met Val Ile Met Gly Glu Leu Glu Pro Ser Glu Gly 
465                 470                 475                 480
Lys Ile Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln Phe Ser Trp 
                485                 490                 495   
Ile Met Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly Val Ser Tyr 
            500                 505                 510  
Asp Glu Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln Leu Glu Glu 
        515                 520                 525        
Asp Ile Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu Gly Glu Gly 
    530                 535                 540           
Gly Ile Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser Leu Ala Arg 
545                 550                 555                 560
Ala Val Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser Pro Phe Gly 
                565                 570                 575 
Tyr Leu Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser Cys Val Cys 
            580                 585                 590   
Lys Leu Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser Lys Met Glu 
        595                 600                 605    
His Leu Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu Gly Ser Ser 
    610                 615                 620             
Tyr Phe Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln Pro Asp Phe 
625                 630                 635                 640 
Ser Ser Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe Ser Ala Glu 
                645                 650                 655  
Arg Arg Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe Ser Leu Glu 
            660                 665                 670   
Gly Asp Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln Ser Phe Lys 
        675                 680                 685  
Gln Thr Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile Leu Asn Pro 
    690                 695                 700        
Ile Asn Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr Pro Leu Gln 
705                 710                 715                 720
Met Asn Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu Arg Arg Leu 
                725                 730                 735 
Ser Leu Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu Pro Arg Ile 
            740                 745                 750    
Ser Val Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg Arg Gln Ser 
        755                 760                 765     
Val Leu Asn Leu Met Thr His Ser Val Asn Gln Gly Gln Asn Ile His 
    770                 775                 780          
Arg Lys Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala Pro Gln Ala 
785                 790                 795                 800
Asn Leu Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser Gln Glu Thr 
                805                 810                 815 
Gly Leu Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu Lys Glu Cys 
            820                 825                 830  
Phe Phe Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr Trp Asn Thr 
        835                 840                 845     
Tyr Leu Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe Val Leu Ile 
    850                 855                 860          
Trp Cys Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser Leu Val Val 
865                 870                 875                 880 
Leu Trp Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly Asn Ser Thr 
                885                 890                 895   
His Ser Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser Thr Ser Ser 
            900                 905                 910     
Tyr Tyr Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr Leu Leu Ala 
        915                 920                 925      
Met Gly Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu Ile Thr Val 
    930                 935                 940       
Ser Lys Ile Leu His His Lys Met Leu His Ser Val Leu Gln Ala Pro 
945                 950                 955                 960
Met Ser Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu Asn Arg Phe 
                965                 970                 975 
Ser Lys Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu Thr Ile Phe 
            980                 985                 990     
Asp Phe Ile Gln Leu Leu Leu Ile Val Ile Gly Ala Ile Ala Val Val 
        995                 1000                1005        
Ala Val Leu Gln Pro Tyr Ile Phe Val Ala Thr Val Pro Val Ile Val 
    1010                1015                1020            
Ala Phe Ile Met Leu Arg Ala Tyr Phe Leu Gln Thr Ser Gln Gln Leu 
1025                1030                1035               1040 
Lys Gln Leu Glu Ser Glu Gly Arg Ser Pro Ile Phe Thr His Leu Val 
                1045                1050                1055  
Thr Ser Leu Lys Gly Leu Trp Thr Leu Arg Ala Phe Gly Arg Gln Pro 
            1060                1065                1070   
Tyr Phe Glu Thr Leu Phe His Lys Ala Leu Asn Leu His Thr Ala Asn 
        1075                1080                1085   
Trp Phe Leu Tyr Leu Ser Thr Leu Arg Trp Phe Gln Met Arg Ile Glu 
    1090                1095                1100           
Met Ile Phe Val Ile Phe Phe Ile Ala Val Thr Phe Ile Ser Ile Leu 
1105                1110                1115               1120
Thr Thr Gly Glu Gly Glu Gly Arg Val Gly Ile Ile Leu Thr Leu Ala 
                1125                1130                1135
Met Asn Ile Met Ser Thr Leu Gln Trp Ala Val Asn Ser Ser Ile Asp 
            1140                1145                1150      
Val Asp Ser Leu Met Arg Ser Val Ser Arg Val Phe Lys Phe Ile Asp 
        1155                1160                1165          
Met Pro Thr Glu Gly Lys Pro Thr Lys Ser Thr Lys Pro Tyr Lys Asn 
    1170                1175                1180             
Gly Gln Leu Ser Lys Val Met Ile Ile Glu Asn Ser His Val Lys Lys 
1185                1190                1195               1200
Asp Asp Ile Trp Pro Ser Gly Gly Gln Met Thr Val Lys Asp Leu Thr 
                1205                1210                1215 
Ala Lys Tyr Thr Glu Gly Gly Asn Ala Ile Leu Glu Asn Ile Ser Phe 
            1220                1225                1230     
Ser Ile Ser Pro Gly Gln Arg Val Gly Leu Leu Gly Arg Thr Gly Ser 
        1235                1240                1245    
Gly Lys Ser Thr Leu Leu Ser Ala Phe Leu Arg Leu Leu Asn Thr Glu 
    1250                1255                1260           
Gly Glu Ile Gln Ile Asp Gly Val Ser Trp Asp Ser Ile Thr Leu Gln 
1265                1270                1275               1280 
Gln Trp Arg Lys Ala Phe Gly Val Ile Pro Gln Lys Val Phe Ile Phe 
                1285                1290                1295 
Ser Gly Thr Phe Arg Lys Asn Leu Asp Pro Tyr Glu Gln Trp Ser Asp 
            1300                1305                1310   
Gln Glu Ile Trp Lys Val Ala Asp Glu Val Gly Leu Arg Ser Val Ile 
        1315                1320                1325       
Glu Gln Phe Pro Gly Lys Leu Asp Phe Val Leu Val Asp Gly Gly Cys 
    1330                1335                1340        
Val Leu Ser His Gly His Lys Gln Leu Met Cys Leu Ala Arg Ser Val 
1345                1350                1355               1360
Leu Ser Lys Ala Lys Ile Leu Leu Leu Asp Glu Pro Ser Ala His Leu 
                1365                1370                1375 
Asp Pro Val Thr Tyr Gln Ile Ile Arg Arg Thr Leu Lys Gln Ala Phe 
            1380                1385                1390      
Ala Asp Cys Thr Val Ile Leu Cys Glu His Arg Ile Glu Ala Met Leu 
        1395                1400                1405        
Glu Cys Gln Gln Phe Leu Val Ile Glu Glu Asn Lys Val Arg Gln Tyr 
    1410                1415                1420          
Asp Ser Ile Gln Lys Leu Leu Asn Glu Arg Ser Leu Phe Arg Gln Ala 
1425                1430                1435               1440 
Ile Ser Pro Ser Asp Arg Val Lys Leu Phe Pro His Arg Asn Ser Ser 
                1445                1450                1455  
Lys Cys Lys Ser Lys Pro Gln Ile Ala Ala Leu Lys Glu Glu Thr Glu 
            1460                1465                1470     
Glu Glu Val Gln Asp Thr Arg Leu
        1475               1480

<210> 6
<211> 1419
<212> PRT
<213> Homo sapiens

<400> 6
Met Gln Arg Ser Pro Leu Glu Lys Ala Ser Val Val Ser Lys Leu Phe 
 1               5                  10                  15 
Phe Ser Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu 
            20                  25                  30  
Glu Leu Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn 
        35                  40                  45     
Leu Ser Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys 
    50                  55                  60             
Lys Asn Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg 
65                  70                  75                  80
Phe Met Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala 
                85                  90                  95 
Val Gln Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp 
            100                 105                 110 
Asn Lys Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys 
        115                 120                 125         
Leu Leu Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly 
    130                 135                 140             
Leu His His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile 
145                 150                 155                 160
Tyr Lys Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser 
                165                 170                 175 
Ile Gly Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp 
            180                 185                 190 
Glu Gly Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val 
        195                 200                 205     
Ala Leu Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe 
    210                 215                 220             
Cys Gly Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu 
225                 230                 235                 240
Gly Arg Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser 
                245                 250                 255
Glu Arg Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val 
            260                 265                 270    
Lys Ala Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu 
        275                 280                 285        
Arg Gln Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr 
    290                 295                 300         
Phe Asn Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu 
305                 310                 315                 320
Ser Val Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile 
                325                 330                 335
Phe Thr Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg 
            340                 345                 350     
Gln Phe Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile 
        355                 360                 365       
Asn Lys Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu 
    370                 375                 380               
Tyr Asn Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe 
385                 390                 395                 400
Trp Glu Glu Thr Ser Leu Leu Met Val Ile Met Gly Glu Leu Glu Pro 
                405                 410                 415 
Ser Glu Gly Lys Ile Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln 
            420                 425                 430  
Phe Ser Trp Ile Met Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly 
        435                 440                 445    
Val Ser Tyr Asp Glu Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln 
    450                 455                 460    
Leu Glu Glu Asp Ile Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu 
465                 470                 475                 480
Gly Glu Gly Gly Ile Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser 
                485                 490                 495 
Leu Ala Arg Ala Val Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser 
            500                 505                 510  
Pro Phe Gly Tyr Leu Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser 
        515                 520                 525      
Cys Val Cys Lys Leu Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser 
    530                 535                 540           
Lys Met Glu His Leu Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu 
545                 550                 555                 560
Gly Ser Ser Tyr Phe Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln 
                565                 570                 575 
Pro Asp Phe Ser Ser Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe 
            580                 585                 590   
Ser Ala Glu Arg Arg Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe 
        595                 600                 605    
Ser Leu Glu Gly Asp Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln 
    610                 615                 620             
Ser Phe Lys Gln Thr Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile 
625                 630                 635                 640
Leu Asn Pro Ile Asn Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr 
                645                 650                 655 
Pro Leu Gln Met Asn Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu 
            660                 665                 670   
Arg Arg Leu Ser Leu Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu 
        675                 680                 685  
Pro Arg Ile Ser Val Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg 
    690                 695                 700        
Arg Gln Ser Val Leu Asn Leu Met Thr His Ser Val Asn Gln Gly Gln 
705                 710                 715                 720
Asn Ile His Arg Lys Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala 
                725                 730                 735
Pro Gln Ala Asn Leu Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser 
            740                 745                 750    
Gln Glu Thr Gly Leu Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu 
        755                 760                 765     
Lys Glu Cys Phe Phe Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr 
    770                 775                 780          
Trp Asn Thr Tyr Leu Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe 
785                 790                 795                 800
Val Leu Ile Trp Cys Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser 
                805                 810                 815 
Leu Val Val Leu Trp Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly 
            820                 825                 830  
Asn Ser Thr His Ser Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser 
        835                 840                 845     
Thr Ser Ser Tyr Tyr Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr 
    850                 855                 860          
Leu Leu Ala Met Gly Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu 
865                 870                 875                 880 
Ile Thr Val Ser Lys Ile Leu His His Lys Met Leu His Ser Val Leu 
                885                 890                 895
Gln Ala Pro Met Ser Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu 
            900                 905                 910     
Asn Arg Phe Ser Lys Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu 
        915                 920                 925      
Thr Ile Phe Asp Phe Ile Gln Leu Leu Leu Ile Val Ile Gly Ala Ile 
    930                 935                 940       
Ala Val Val Ala Val Leu Gln Pro Tyr Ile Phe Val Ala Thr Val Pro 
945                 950                 955                 960
Val Ile Val Ala Phe Ile Met Leu Arg Ala Tyr Phe Leu Gln Thr Ser 
                965                 970                 975 
Gln Gln Leu Lys Gln Leu Glu Ser Glu Gly Arg Ser Pro Ile Phe Thr 
            980                 985                 990     
His Leu Val Thr Ser Leu Lys Gly Leu Trp Thr Leu Arg Ala Phe Gly 
        995                 1000                1005        
Arg Gln Pro Tyr Phe Glu Thr Leu Phe His Lys Ala Leu Asn Leu His 
    1010                1015                1020            
Thr Ala Asn Trp Phe Leu Tyr Leu Ser Thr Leu Arg Trp Phe Gln Met 
1025                1030                1035               1040
Arg Ile Glu Met Ile Phe Val Ile Phe Phe Ile Ala Val Thr Phe Ile 
                1045                1050                1055 
Ser Ile Leu Thr Thr Gly Glu Gly Glu Gly Arg Val Gly Ile Ile Leu 
            1060                1065                1070   
Thr Leu Ala Met Asn Ile Met Ser Thr Leu Gln Trp Ala Val Asn Ser 
        1075                1080                1085   
Ser Ile Asp Val Asp Ser Leu Met Arg Ser Val Ser Arg Val Phe Lys 
    1090                1095                1100           
Phe Ile Asp Met Pro Thr Glu Gly Lys Pro Thr Lys Ser Thr Lys Pro 
1105                1110                1115               1120
Tyr Lys Asn Gly Gln Leu Ser Lys Val Met Ile Ile Glu Asn Ser His 
                1125                1130                1135  
Val Lys Lys Asp Asp Ile Trp Pro Ser Gly Gly Gln Met Thr Val Lys 
            1140                1145                1150      
Asp Leu Thr Ala Lys Tyr Thr Glu Gly Gly Asn Ala Ile Leu Glu Asn 
        1155                1160                1165         
Ile Ser Phe Ser Ile Ser Pro Gly Gln Arg Val Gly Leu Leu Gly Arg 
    1170                1175                1180             
Thr Gly Ser Gly Lys Ser Thr Leu Leu Ser Ala Phe Leu Arg Leu Leu 
1185                1190                1195               1200
Asn Thr Glu Gly Glu Ile Gln Ile Asp Gly Val Ser Trp Asp Ser Ile 
                1205                1210                1215 
Thr Leu Gln Gln Trp Arg Lys Ala Phe Gly Val Ile Pro Gln Lys Val 
            1220                1225                1230     
Phe Ile Phe Ser Gly Thr Phe Arg Lys Asn Leu Asp Pro Tyr Glu Gln 
        1235                1240                1245    
Trp Ser Asp Gln Glu Ile Trp Lys Val Ala Asp Glu Val Gly Leu Arg 
    1250                1255                1260           
Ser Val Ile Glu Gln Phe Pro Gly Lys Leu Asp Phe Val Leu Val Asp 
1265                1270                1275               1280 
Gly Gly Cys Val Leu Ser His Gly His Lys Gln Leu Met Cys Leu Ala 
                1285                1290                1295
Arg Ser Val Leu Ser Lys Ala Lys Ile Leu Leu Leu Asp Glu Pro Ser 
            1300                1305                1310    
Ala His Leu Asp Pro Val Thr Tyr Gln Ile Ile Arg Arg Thr Leu Lys 
        1315                1320                1325       
Gln Ala Phe Ala Asp Cys Thr Val Ile Leu Cys Glu His Arg Ile Glu 
    1330                1335                1340        
Ala Met Leu Glu Cys Gln Gln Phe Leu Val Ile Glu Glu Asn Lys Val 
1345                1350                1355               1360 
Arg Gln Tyr Asp Ser Ile Gln Lys Leu Leu Asn Glu Arg Ser Leu Phe 
                1365                1370                1375 
Arg Gln Ala Ile Ser Pro Ser Asp Arg Val Lys Leu Phe Pro His Arg 
            1380                1385                1390      
Asn Ser Ser Lys Cys Lys Ser Lys Pro Gln Ile Ala Ala Leu Lys Glu 
        1395                1400                1405        
Glu Thr Glu Glu Glu Val Gln Asp Thr Arg Leu
    1410                1415                   