                               SEQUENCE LISTING

<110> MEMORIAL SLOAN KETTERING CANCER CENTER
 
<120> COMPOSITIONS FOR SUPPRESSING TRIM28 AND USES THEREOF

<130> 115872-0642

<140> PCT/US2020/017049
<141> 2020-02-06

<150> 62/802,520
<151> 2019-02-07

<160> 23    

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
ttacagtaga ctgttcgctc tc                                                22


<210> 2
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
ttctgcacat cagacacctg gc                                                22


<210> 3
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
ttgaactgtt tgaacatgcg gc                                                22


<210> 4
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ttaacttgtt gaattgcttg aa                                                22


<210> 5
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
ttcaataaca ataaggttgt ag                                                22


<210> 6
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
tagatcaact tcttagaaag ca                                                22


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ctacaggccg agtgcaaaca                                                   20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
gagagcgcct gcgacccgag                                                   20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
ccagcgggtg aagtacacca                                                   20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
cccagccacc agctactgtg                                                   20


<210> 11
<211> 3364
<212> DNA
<213> Homo sapiens

<400> 11
agtgacgcag aggctggaga cgactctacg gcggcgaaga gacgcgggtt gaggaagagg       60

gacggattgc ccatgcgctt gggcgcacag cggcccgctt ctgtgtggtc tggaggtgga      120

gctgagaggg gaatcacact ctataaaggt tcgcataccc cactggcgga ttcaattgcg      180

gcagtgacgt cacagaggcc ccgccccgcc cccacaagag ccccaccgac gtggggttgg      240

cggtggtgga aggactagga gttggcgcgt gcgtactggc ggcctctccc gcaccgaccg      300

gcctgggccc cgcccccggg cgtgaggcgc ccaatgcgcg tgcgcggcgg cgtcggcgcc      360

agttatttct gtcccgcccc ccggcctcgg ctctttctgc gagcgggcgc gcgggcgagc      420

ggttgtgctt gtgcttgtgg cgcgtggtgc gggtttcggc ggcggctgag gaagaagcgc      480

gggcggcgcc ttcgggaggc gagcaggcag cagttggccg tgccgtagca gcgtcccgcg      540

cgcggcgggc agcggcccag gaggcgcgtg gcggcgctcg gcctcgcggc ggcggcggcg      600

gcagcggccc agcagttggc ggcgagcgcg tctgcgcctg cgcggcgggc cccgcgcccc      660

tcctcccccc ctgggcgccc ccggcggcgt gtgaatggcg gcctccgcgg cggcagcctc      720

ggcagcagcg gcctcggccg cctctggcag cccgggcccg ggcgagggct ccgctggcgg      780

cgaaaagcgc tccaccgccc cttcggccgc agcctcggcc tctgcctcag ccgcggcgtc      840

gtcgcccgcg gggggcggcg ccgaggcgct ggagctgctg gagcactgcg gcgtgtgcag      900

agagcgcctg cgacccgaga gggagccccg cctgctgccc tgtttgcact cggcctgtag      960

tgcctgctta gggcccgcgg cccccgccgc cgccaacagc tcgggggacg gcggggcggc     1020

gggcgacggc accgtggtgg actgtcccgt gtgcaagcaa cagtgcttct ccaaagacat     1080

cgtggagaat tatttcatgc gtgatagtgg cagcaaggct gccaccgacg cccaggatgc     1140

gaaccagtgc tgcactagct gtgaggataa tgccccagcc accagctact gtgtggagtg     1200

ctcggagcct ctgtgtgaga cctgtgtaga ggcgcaccag cgggtgaagt acaccaagga     1260

ccatactgtg cgctctactg ggccagccaa gtctcgggat ggtgaacgta ctgtctattg     1320

caacgtacac aagcatgaac cccttgtgct gttttgtgag agctgtgata ctctcacctg     1380

ccgagactgc cagctcaatg cccacaagga ccaccagtac cagttcttag aggatgcagt     1440

gaggaaccag cgcaagctcc tggcctcact ggtgaagcgc cttggggaca aacatgcaac     1500

attgcagaag agcaccaagg aggttcgcag ctcaatccgc caggtgtctg acgtacagaa     1560

gcgtgtgcaa gtggatgtca agatggccat cctgcagatc atgaaggagc tgaataagcg     1620

gggccgtgtg ctggtcaatg atgcccagaa ggtgactgag gggcagcagg agcgcctgga     1680

gcggcagcac tggaccatga ccaagatcca gaagcaccag gagcacattc tgcgctttgc     1740

ctcttgggct ctggagagtg acaacaacac agcccttttg ctttctaaga agttgatcta     1800

cttccagctg caccgggccc tcaagatgat tgtggatccc gtggagccac atggcgagat     1860

gaagtttcag tgggacctca atgcctggac caagagtgcc gaggcctttg gcaagattgt     1920

ggcagagcgt cctggcacta actcaacagg ccctgcaccc atggcccctc caagagcccc     1980

agggcccctg agcaagcagg gctctggcag cagccagccc atggaggtgc aggaaggcta     2040

tggctttggg tcaggagatg atccctactc aagtgcagag ccccatgtgt caggtgtgaa     2100

acggtcccgc tcaggtgagg gcgaggtgag cggccttatg cgcaaggtgc cacgagtgag     2160

ccttgaacgc ctggacctgg acctcacagc tgacagccag ccacccgtct tcaaggtctt     2220

cccaggcagt accactgagg actacaacct tattgttatt gaacgtggcg ctgccgctgc     2280

agctaccggc cagccaggga ctgcgcctgc aggaacccct ggtgccccac ccctggctgg     2340

catggccatt gtcaaggagg aggagacgga ggctgccatt ggagcccctc ctactgccac     2400

tgagggccct gagaccaaac ctgtgcttat ggctcttgcg gagggtcctg gtgctgaggg     2460

tccccgcctg gcctcaccta gtggcagcac cagctcaggg ctggaggtgg tggctcctga     2520

gggtacctca gccccaggtg gtggcccggg aaccctggat gacagtgcca ccatttgccg     2580

tgtctgccag aagccaggcg atctggttat gtgcaaccag tgtgagtttt gtttccacct     2640

ggactgtcac ctgccggccc tgcaggatgt accaggggag gagtggagct gctcactctg     2700

ccatgtgctc cctgacctga aggaggagga tggcagcctc agcctggatg gtgcagacag     2760

cactggcgtg gtggccaagc tctcaccagc caaccagcgg aaatgtgagc gtgtactgct     2820

ggccctattc tgtcacgaac cctgccgccc cctgcatcag ctggctaccg actccacctt     2880

ctccctggac cagcccggtg gcaccctgga tctgaccctg atccgtgccc gcctccagga     2940

gaagttgtca cctccctaca gctccccaca ggagtttgcc caggatgtgg gccgcatgtt     3000

caagcaattc aacaagttaa ctgaggacaa ggcagacgtg cagtccatca tcggcctgca     3060

gcgcttcttc gagacgcgca tgaacgaggc cttcggtgac accaagttct ctgctgtgct     3120

ggtggagccc ccgccgatga gcctgcctgg tgctggcctg agttcccagg agctgtctgg     3180

tggccctggt gatggcccct gaggctggag cccccatggc cagcccagcc tggctctgtt     3240

ctctgtcctg tcaccccatc cccactcccc tggtggcctg actcccactc cctggtggcc     3300

ccatccccca gttcctcacg atatggtttt tacttctgtg gatttaataa aaacttcacc     3360

agtt                                                                  3364


<210> 12
<211> 835
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala 
1               5                   10                  15      


Ser Gly Ser Pro Gly Pro Gly Glu Gly Ser Ala Gly Gly Glu Lys Arg 
            20                  25                  30          


Ser Thr Ala Pro Ser Ala Ala Ala Ser Ala Ser Ala Ser Ala Ala Ala 
        35                  40                  45              


Ser Ser Pro Ala Gly Gly Gly Ala Glu Ala Leu Glu Leu Leu Glu His 
    50                  55                  60                  


Cys Gly Val Cys Arg Glu Arg Leu Arg Pro Glu Arg Glu Pro Arg Leu 
65                  70                  75                  80  


Leu Pro Cys Leu His Ser Ala Cys Ser Ala Cys Leu Gly Pro Ala Ala 
                85                  90                  95      


Pro Ala Ala Ala Asn Ser Ser Gly Asp Gly Gly Ala Ala Gly Asp Gly 
            100                 105                 110         


Thr Val Val Asp Cys Pro Val Cys Lys Gln Gln Cys Phe Ser Lys Asp 
        115                 120                 125             


Ile Val Glu Asn Tyr Phe Met Arg Asp Ser Gly Ser Lys Ala Ala Thr 
    130                 135                 140                 


Asp Ala Gln Asp Ala Asn Gln Cys Cys Thr Ser Cys Glu Asp Asn Ala 
145                 150                 155                 160 


Pro Ala Thr Ser Tyr Cys Val Glu Cys Ser Glu Pro Leu Cys Glu Thr 
                165                 170                 175     


Cys Val Glu Ala His Gln Arg Val Lys Tyr Thr Lys Asp His Thr Val 
            180                 185                 190         


Arg Ser Thr Gly Pro Ala Lys Ser Arg Asp Gly Glu Arg Thr Val Tyr 
        195                 200                 205             


Cys Asn Val His Lys His Glu Pro Leu Val Leu Phe Cys Glu Ser Cys 
    210                 215                 220                 


Asp Thr Leu Thr Cys Arg Asp Cys Gln Leu Asn Ala His Lys Asp His 
225                 230                 235                 240 


Gln Tyr Gln Phe Leu Glu Asp Ala Val Arg Asn Gln Arg Lys Leu Leu 
                245                 250                 255     


Ala Ser Leu Val Lys Arg Leu Gly Asp Lys His Ala Thr Leu Gln Lys 
            260                 265                 270         


Ser Thr Lys Glu Val Arg Ser Ser Ile Arg Gln Val Ser Asp Val Gln 
        275                 280                 285             


Lys Arg Val Gln Val Asp Val Lys Met Ala Ile Leu Gln Ile Met Lys 
    290                 295                 300                 


Glu Leu Asn Lys Arg Gly Arg Val Leu Val Asn Asp Ala Gln Lys Val 
305                 310                 315                 320 


Thr Glu Gly Gln Gln Glu Arg Leu Glu Arg Gln His Trp Thr Met Thr 
                325                 330                 335     


Lys Ile Gln Lys His Gln Glu His Ile Leu Arg Phe Ala Ser Trp Ala 
            340                 345                 350         


Leu Glu Ser Asp Asn Asn Thr Ala Leu Leu Leu Ser Lys Lys Leu Ile 
        355                 360                 365             


Tyr Phe Gln Leu His Arg Ala Leu Lys Met Ile Val Asp Pro Val Glu 
    370                 375                 380                 


Pro His Gly Glu Met Lys Phe Gln Trp Asp Leu Asn Ala Trp Thr Lys 
385                 390                 395                 400 


Ser Ala Glu Ala Phe Gly Lys Ile Val Ala Glu Arg Pro Gly Thr Asn 
                405                 410                 415     


Ser Thr Gly Pro Ala Pro Met Ala Pro Pro Arg Ala Pro Gly Pro Leu 
            420                 425                 430         


Ser Lys Gln Gly Ser Gly Ser Ser Gln Pro Met Glu Val Gln Glu Gly 
        435                 440                 445             


Tyr Gly Phe Gly Ser Gly Asp Asp Pro Tyr Ser Ser Ala Glu Pro His 
    450                 455                 460                 


Val Ser Gly Val Lys Arg Ser Arg Ser Gly Glu Gly Glu Val Ser Gly 
465                 470                 475                 480 


Leu Met Arg Lys Val Pro Arg Val Ser Leu Glu Arg Leu Asp Leu Asp 
                485                 490                 495     


Leu Thr Ala Asp Ser Gln Pro Pro Val Phe Lys Val Phe Pro Gly Ser 
            500                 505                 510         


Thr Thr Glu Asp Tyr Asn Leu Ile Val Ile Glu Arg Gly Ala Ala Ala 
        515                 520                 525             


Ala Ala Thr Gly Gln Pro Gly Thr Ala Pro Ala Gly Thr Pro Gly Ala 
    530                 535                 540                 


Pro Pro Leu Ala Gly Met Ala Ile Val Lys Glu Glu Glu Thr Glu Ala 
545                 550                 555                 560 


Ala Ile Gly Ala Pro Pro Thr Ala Thr Glu Gly Pro Glu Thr Lys Pro 
                565                 570                 575     


Val Leu Met Ala Leu Ala Glu Gly Pro Gly Ala Glu Gly Pro Arg Leu 
            580                 585                 590         


Ala Ser Pro Ser Gly Ser Thr Ser Ser Gly Leu Glu Val Val Ala Pro 
        595                 600                 605             


Glu Gly Thr Ser Ala Pro Gly Gly Gly Pro Gly Thr Leu Asp Asp Ser 
    610                 615                 620                 


Ala Thr Ile Cys Arg Val Cys Gln Lys Pro Gly Asp Leu Val Met Cys 
625                 630                 635                 640 


Asn Gln Cys Glu Phe Cys Phe His Leu Asp Cys His Leu Pro Ala Leu 
                645                 650                 655     


Gln Asp Val Pro Gly Glu Glu Trp Ser Cys Ser Leu Cys His Val Leu 
            660                 665                 670         


Pro Asp Leu Lys Glu Glu Asp Gly Ser Leu Ser Leu Asp Gly Ala Asp 
        675                 680                 685             


Ser Thr Gly Val Val Ala Lys Leu Ser Pro Ala Asn Gln Arg Lys Cys 
    690                 695                 700                 


Glu Arg Val Leu Leu Ala Leu Phe Cys His Glu Pro Cys Arg Pro Leu 
705                 710                 715                 720 


His Gln Leu Ala Thr Asp Ser Thr Phe Ser Leu Asp Gln Pro Gly Gly 
                725                 730                 735     


Thr Leu Asp Leu Thr Leu Ile Arg Ala Arg Leu Gln Glu Lys Leu Ser 
            740                 745                 750         


Pro Pro Tyr Ser Ser Pro Gln Glu Phe Ala Gln Asp Val Gly Arg Met 
        755                 760                 765             


Phe Lys Gln Phe Asn Lys Leu Thr Glu Asp Lys Ala Asp Val Gln Ser 
    770                 775                 780                 


Ile Ile Gly Leu Gln Arg Phe Phe Glu Thr Arg Met Asn Glu Ala Phe 
785                 790                 795                 800 


Gly Asp Thr Lys Phe Ser Ala Val Leu Val Glu Pro Pro Pro Met Ser 
                805                 810                 815     


Leu Pro Gly Ala Gly Leu Ser Ser Gln Glu Leu Ser Gly Gly Pro Gly 
            820                 825                 830         


Asp Gly Pro 
        835 


<210> 13
<211> 3255
<212> DNA
<213> Mus musculus

<400> 13
ggacctgcgc gctcaagcac gcgggttgcc agcctgggtg caccgtgcgg tgggcatggg       60

agacgtcaag cacgcactct gcgggtgaat tcctcaccag cagcattgct actctggatc      120

tagaggggcg gcagcgagtg gaagggaggg ccctggcgcg tgcgtaatct gcgccccgcc      180

cccaggctgc ggtgcccaac gcgcgtgcgc ggcgtcgtcg gcgccagata tttctgtccc      240

gcctccaggc cgcggctctt tctgcgagcg gcgcgcggtc aggcggttgt tcgcaagtct      300

tgcggcgcga gtgtctcaga agcgagggag gaggcggcgc tggtggcggc gccgtcgtct      360

gtacagaggc ccgcagccag cggcttggcc gcatctcgac agcgcctggg gcgcggcggg      420

cgtcggccca ggagacgcgt ggcggcgctc ggcctcgcgg catcggcggc tgcctggccg      480

ttggcggcga gcgcacttgc gcctgcgcag cgggctccgt gcccctcctc ccctgggcgg      540

cccccccacc cccccggcgg cgtgtgaatg gcggcctcgg cggcagcgac tgcagcggcc      600

tcggccgcga cggccgcctc ggcggcctct ggtagcccag ggtcgggcga gggctcggcg      660

ggcggtgaga agcgtccggc tgcttcctca gccgcggcgg cctctgcagc cgcgtcgtcc      720

cctgcggggg gcggtggcga ggcgcaggag cttctggagc actgcggcgt gtgtcgcgag      780

cgcctgcggc ccgagcggga tcctcggctg ctgccctgtc tacattcggc ctgcagtgcc      840

tgcctgggcc ccgctacacc cgccgcagcg aataattcgg gggatggcgg ctcggcgggc      900

gacggcgcta tggtggattg tccagtgtgc aaacagcagt gctactccaa agacatcgtg      960

gagaattatt ttatgcgtga tagtggcagt aaggcctctt ctgattccca ggatgctaac     1020

cagtgctgca ctagctgtga agataatgcc ccagccacta gctattgtgt ggagtgctct     1080

gaaccacttt gtgagacctg tgtggaggct caccagcggg tgaaatacac caaggaccac     1140

actgtgcgct ccacaggacc tgctaagact cgagatggag agcgaacagt ctactgtaat     1200

gtgcacaagc atgagcccct cgtgctgttc tgtgagagct gtgacacact cacctgccgc     1260

gactgccagc tcaacgctca caaggaccat cagtaccagt ttttggaaga tgcagtgagg     1320

aaccaacgta aactcttggc ttcactggtg aaacgtcttg gggacaaaca tgccacactt     1380

cagaaaaaca ccaaggaggt tcgaagctcg atccgccagg tgtctgatgt gcagaagcga     1440

gtgcaggttg atgtcaagat ggccattctg cagatcatga aggagctgaa taagcggggt     1500

cgagttctgg tcaatgatgc ccagaaggtg accgagggtc agcaggaacg tctggagcgc     1560

cagcactgga ccatgaccaa aattcagaag caccaggaac acattttgcg ttttgcctct     1620

tgggctctgg agagtgataa caatacagct ctcttgctct ctaagaagct gatctatttc     1680

cagctgcatc gggccctcaa aatgattgtg gatcctgtgg agcctcatgg tgagatgaag     1740

tttcagtggg atctcaatgc ctggaccaag agtgctgaag cctttggcaa gattgtggct     1800

gagcgtcctg gtacgaactc cacaggtcct gggcccatgg ctcctccaag agccccaggc     1860

cctctaagca agcaaggttc tggcagtagc cagcccatgg aagtacaaga gggatatggc     1920

tttgggtcag atgatcccta ttcaagtgca gagccgcatg tatcaggcat gaagcggtcc     1980

cgctctggtg agggagaggt aagtggcctc ttaaggaagg tgccacgtgt gagccttgaa     2040

cgcctggatc tggacctcac ctctgacagc cagccaccag tcttcaaggt ctttcctgga     2100

agcactactg aggactacaa tctgattgtt attgagcgtg gtgctgctgc agcagctgct     2160

ggtcaggctg ggactgtgcc accaggagcc cctggtgccc caccccttcc tggcatggcc     2220

attgtcaagg aagaagagac agaagctgct attggagctc ccccggctgc ccccgagggt     2280

cctgaaacca agcctgtgtt gatgcctctg actgaaggtc ctggtgccga gggacctcgt     2340

ctagcttcac ctagtggcag taccagctca ggcttggagg tggtggctcc tgaggttacc     2400

tcagccccag taagtgggcc aggtatcctg gatgacagtg ccactatctg ccgtgtctgc     2460

cagaaaccag gtgacctggt catgtgtaac cagtgcgaat tttgcttcca cctggattgc     2520

cacctccctg ccctgcagga tgttccaggg gaggaatgga gttgctcact ctgccacgtg     2580

ctccctgacc taaaggagga agatggaagc ctcagcctgg atggagcaga tagcactggt     2640

gtggtagcta aactctcacc agccaaccag cggaaatgtg agcgtgttct cctggccctg     2700

ttctgccatg aaccatgccg tcccttgcat cagctggcta ccgactctac attctccatg     2760

gagcagcctg gtggtaccct agacctgacc ttgattcgtg ctcgcctcca agagaagctg     2820

tcacctcctt atagctcccc ccaggagttt gctcaagatg tgggccgcat gttcaaacag     2880

ttcaacaagc tgactgagga caaggcagat gttcagtcca tcatcggctt gcagcgcttc     2940

tttgagacac gcatgaatga tgcctttggt gacaccaagt tttctgctgt gctggtagaa     3000

ccaccaccat tgaaccttcc cagtgctggc ctaagttctc aggagctctc tggccctggt     3060

gatggcccct gaagctgggg ctcttgtggt cagcccagtc cagctctggt ctctgtattt     3120

tcaccccata ccctgtcctt tggtggcctg actcctgttc ttgctggccc catcgtcccc     3180

tcagtccctc ttcacaaaat ggtttttact tctgtggatt taataaaaac ttcactgagt     3240

caaaaaaaaa aaaaa                                                      3255


<210> 14
<211> 834
<212> PRT
<213> Mus musculus

<400> 14
Met Ala Ala Ser Ala Ala Ala Thr Ala Ala Ala Ser Ala Ala Thr Ala 
1               5                   10                  15      


Ala Ser Ala Ala Ser Gly Ser Pro Gly Ser Gly Glu Gly Ser Ala Gly 
            20                  25                  30          


Gly Glu Lys Arg Pro Ala Ala Ser Ser Ala Ala Ala Ala Ser Ala Ala 
        35                  40                  45              


Ala Ser Ser Pro Ala Gly Gly Gly Gly Glu Ala Gln Glu Leu Leu Glu 
    50                  55                  60                  


His Cys Gly Val Cys Arg Glu Arg Leu Arg Pro Glu Arg Asp Pro Arg 
65                  70                  75                  80  


Leu Leu Pro Cys Leu His Ser Ala Cys Ser Ala Cys Leu Gly Pro Ala 
                85                  90                  95      


Thr Pro Ala Ala Ala Asn Asn Ser Gly Asp Gly Gly Ser Ala Gly Asp 
            100                 105                 110         


Gly Ala Met Val Asp Cys Pro Val Cys Lys Gln Gln Cys Tyr Ser Lys 
        115                 120                 125             


Asp Ile Val Glu Asn Tyr Phe Met Arg Asp Ser Gly Ser Lys Ala Ser 
    130                 135                 140                 


Ser Asp Ser Gln Asp Ala Asn Gln Cys Cys Thr Ser Cys Glu Asp Asn 
145                 150                 155                 160 


Ala Pro Ala Thr Ser Tyr Cys Val Glu Cys Ser Glu Pro Leu Cys Glu 
                165                 170                 175     


Thr Cys Val Glu Ala His Gln Arg Val Lys Tyr Thr Lys Asp His Thr 
            180                 185                 190         


Val Arg Ser Thr Gly Pro Ala Lys Thr Arg Asp Gly Glu Arg Thr Val 
        195                 200                 205             


Tyr Cys Asn Val His Lys His Glu Pro Leu Val Leu Phe Cys Glu Ser 
    210                 215                 220                 


Cys Asp Thr Leu Thr Cys Arg Asp Cys Gln Leu Asn Ala His Lys Asp 
225                 230                 235                 240 


His Gln Tyr Gln Phe Leu Glu Asp Ala Val Arg Asn Gln Arg Lys Leu 
                245                 250                 255     


Leu Ala Ser Leu Val Lys Arg Leu Gly Asp Lys His Ala Thr Leu Gln 
            260                 265                 270         


Lys Asn Thr Lys Glu Val Arg Ser Ser Ile Arg Gln Val Ser Asp Val 
        275                 280                 285             


Gln Lys Arg Val Gln Val Asp Val Lys Met Ala Ile Leu Gln Ile Met 
    290                 295                 300                 


Lys Glu Leu Asn Lys Arg Gly Arg Val Leu Val Asn Asp Ala Gln Lys 
305                 310                 315                 320 


Val Thr Glu Gly Gln Gln Glu Arg Leu Glu Arg Gln His Trp Thr Met 
                325                 330                 335     


Thr Lys Ile Gln Lys His Gln Glu His Ile Leu Arg Phe Ala Ser Trp 
            340                 345                 350         


Ala Leu Glu Ser Asp Asn Asn Thr Ala Leu Leu Leu Ser Lys Lys Leu 
        355                 360                 365             


Ile Tyr Phe Gln Leu His Arg Ala Leu Lys Met Ile Val Asp Pro Val 
    370                 375                 380                 


Glu Pro His Gly Glu Met Lys Phe Gln Trp Asp Leu Asn Ala Trp Thr 
385                 390                 395                 400 


Lys Ser Ala Glu Ala Phe Gly Lys Ile Val Ala Glu Arg Pro Gly Thr 
                405                 410                 415     


Asn Ser Thr Gly Pro Gly Pro Met Ala Pro Pro Arg Ala Pro Gly Pro 
            420                 425                 430         


Leu Ser Lys Gln Gly Ser Gly Ser Ser Gln Pro Met Glu Val Gln Glu 
        435                 440                 445             


Gly Tyr Gly Phe Gly Ser Asp Asp Pro Tyr Ser Ser Ala Glu Pro His 
    450                 455                 460                 


Val Ser Gly Met Lys Arg Ser Arg Ser Gly Glu Gly Glu Val Ser Gly 
465                 470                 475                 480 


Leu Leu Arg Lys Val Pro Arg Val Ser Leu Glu Arg Leu Asp Leu Asp 
                485                 490                 495     


Leu Thr Ser Asp Ser Gln Pro Pro Val Phe Lys Val Phe Pro Gly Ser 
            500                 505                 510         


Thr Thr Glu Asp Tyr Asn Leu Ile Val Ile Glu Arg Gly Ala Ala Ala 
        515                 520                 525             


Ala Ala Ala Gly Gln Ala Gly Thr Val Pro Pro Gly Ala Pro Gly Ala 
    530                 535                 540                 


Pro Pro Leu Pro Gly Met Ala Ile Val Lys Glu Glu Glu Thr Glu Ala 
545                 550                 555                 560 


Ala Ile Gly Ala Pro Pro Ala Ala Pro Glu Gly Pro Glu Thr Lys Pro 
                565                 570                 575     


Val Leu Met Pro Leu Thr Glu Gly Pro Gly Ala Glu Gly Pro Arg Leu 
            580                 585                 590         


Ala Ser Pro Ser Gly Ser Thr Ser Ser Gly Leu Glu Val Val Ala Pro 
        595                 600                 605             


Glu Val Thr Ser Ala Pro Val Ser Gly Pro Gly Ile Leu Asp Asp Ser 
    610                 615                 620                 


Ala Thr Ile Cys Arg Val Cys Gln Lys Pro Gly Asp Leu Val Met Cys 
625                 630                 635                 640 


Asn Gln Cys Glu Phe Cys Phe His Leu Asp Cys His Leu Pro Ala Leu 
                645                 650                 655     


Gln Asp Val Pro Gly Glu Glu Trp Ser Cys Ser Leu Cys His Val Leu 
            660                 665                 670         


Pro Asp Leu Lys Glu Glu Asp Gly Ser Leu Ser Leu Asp Gly Ala Asp 
        675                 680                 685             


Ser Thr Gly Val Val Ala Lys Leu Ser Pro Ala Asn Gln Arg Lys Cys 
    690                 695                 700                 


Glu Arg Val Leu Leu Ala Leu Phe Cys His Glu Pro Cys Arg Pro Leu 
705                 710                 715                 720 


His Gln Leu Ala Thr Asp Ser Thr Phe Ser Met Glu Gln Pro Gly Gly 
                725                 730                 735     


Thr Leu Asp Leu Thr Leu Ile Arg Ala Arg Leu Gln Glu Lys Leu Ser 
            740                 745                 750         


Pro Pro Tyr Ser Ser Pro Gln Glu Phe Ala Gln Asp Val Gly Arg Met 
        755                 760                 765             


Phe Lys Gln Phe Asn Lys Leu Thr Glu Asp Lys Ala Asp Val Gln Ser 
    770                 775                 780                 


Ile Ile Gly Leu Gln Arg Phe Phe Glu Thr Arg Met Asn Asp Ala Phe 
785                 790                 795                 800 


Gly Asp Thr Lys Phe Ser Ala Val Leu Val Glu Pro Pro Pro Leu Asn 
                805                 810                 815     


Leu Pro Ser Ala Gly Leu Ser Ser Gln Glu Leu Ser Gly Pro Gly Asp 
            820                 825                 830         


Gly Pro 
        


<210> 15
<211> 137
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, t, g, unknown or other

<400> 15
nnnnnnnnnn nnnnnnnnnn gtttttgtac tctcaagatt tagaaataaa tcttgcagaa       60

gctacaaaga taaggcttca tgccgaaatc aacaccctgt cattttatgg cagggtgttt      120

tcgttattta atttttt                                                     137


<210> 16
<211> 123
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, t, g, unknown or other

<400> 16
nnnnnnnnnn nnnnnnnnnn gtttttgtac tctcagaaat gcagaagcta caaagataag       60

gcttcatgcc gaaatcaaca ccctgtcatt ttatggcagg gtgttttcgt tatttaattt      120

ttt                                                                    123


<210> 17
<211> 110
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, t, g, unknown or other

<400> 17
nnnnnnnnnn nnnnnnnnnn gtttttgtac tctcagaaat gcagaagcta caaagataag       60

gcttcatgcc gaaatcaaca ccctgtcatt ttatggcagg gtgttttttt                 110


<210> 18
<211> 102
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, t, g, unknown or other

<400> 18
nnnnnnnnnn nnnnnnnnnn gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tt                         102


<210> 19
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, t, g, unknown or other

<400> 19
nnnnnnnnnn nnnnnnnnnn gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gttttttt                                          88


<210> 20
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, t, g, unknown or other

<400> 20
nnnnnnnnnn nnnnnnnnnn gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcatt tttttt                                                       76


<210> 21
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ttattgacat cgttcacctt ga                                                22


<210> 22
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
tgtaacctca cattgaacct ga                                                22


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
gtacaaccct cctgaccatg                                                   20


