                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Shokat, Kevan M.
       Zhang, Ziyang
 
<120>  IMMUNOPHILIN-DEPENDENT INHIBITORS AND USES THEREOF

<130>  048536-635001WO

<150>  US 62/802,665
<151>  2019-02-07

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  2549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210>  2
<211>  1210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  3
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  4
<211>  2527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Ala Ser Gly Ser Cys Gln Gly Cys Glu Glu Asp Glu Glu Thr Leu 
1               5                   10                  15      


Lys Lys Leu Ile Val Arg Leu Asn Asn Val Gln Glu Gly Lys Gln Ile 
            20                  25                  30          


Glu Thr Leu Val Gln Ile Leu Glu Asp Leu Leu Val Phe Thr Tyr Ser 
        35                  40                  45              


Glu Arg Ala Ser Lys Leu Phe Gln Gly Lys Asn Ile His Val Pro Leu 
    50                  55                  60                  


Leu Ile Val Leu Asp Ser Tyr Met Arg Val Ala Ser Val Gln Gln Val 
65                  70                  75                  80  


Gly Trp Ser Leu Leu Cys Lys Leu Ile Glu Val Cys Pro Gly Thr Met 
                85                  90                  95      


Gln Ser Leu Met Gly Pro Gln Asp Val Gly Asn Asp Trp Glu Val Leu 
            100                 105                 110         


Gly Val His Gln Leu Ile Leu Lys Met Leu Thr Val His Asn Ala Ser 
        115                 120                 125             


Val Asn Leu Ser Val Ile Gly Leu Lys Thr Leu Asp Leu Leu Leu Thr 
    130                 135                 140                 


Ser Gly Lys Ile Thr Leu Leu Ile Leu Asp Glu Glu Ser Asp Ile Phe 
145                 150                 155                 160 


Met Leu Ile Phe Asp Ala Met His Ser Phe Pro Ala Asn Asp Glu Val 
                165                 170                 175     


Gln Lys Leu Gly Cys Lys Ala Leu His Val Leu Phe Glu Arg Val Ser 
            180                 185                 190         


Glu Glu Gln Leu Thr Glu Phe Val Glu Asn Lys Asp Tyr Met Ile Leu 
        195                 200                 205             


Leu Ser Ala Leu Thr Asn Phe Lys Asp Glu Glu Glu Ile Val Leu His 
    210                 215                 220                 


Val Leu His Cys Leu His Ser Leu Ala Ile Pro Cys Asn Asn Val Glu 
225                 230                 235                 240 


Val Leu Met Ser Gly Asn Val Arg Cys Tyr Asn Ile Val Val Glu Ala 
                245                 250                 255     


Met Lys Ala Phe Pro Met Ser Glu Arg Ile Gln Glu Val Ser Cys Cys 
            260                 265                 270         


Leu Leu His Arg Leu Thr Leu Gly Asn Phe Phe Asn Ile Leu Val Leu 
        275                 280                 285             


Asn Glu Val His Glu Phe Val Val Lys Ala Val Gln Gln Tyr Pro Glu 
    290                 295                 300                 


Asn Ala Ala Leu Gln Ile Ser Ala Leu Ser Cys Leu Ala Leu Leu Thr 
305                 310                 315                 320 


Glu Thr Ile Phe Leu Asn Gln Asp Leu Glu Glu Lys Asn Glu Asn Gln 
                325                 330                 335     


Glu Asn Asp Asp Glu Gly Glu Glu Asp Lys Leu Phe Trp Leu Glu Ala 
            340                 345                 350         


Cys Tyr Lys Ala Leu Thr Trp His Arg Lys Asn Lys His Val Gln Glu 
        355                 360                 365             


Ala Ala Cys Trp Ala Leu Asn Asn Leu Leu Met Tyr Gln Asn Ser Leu 
    370                 375                 380                 


His Glu Lys Ile Gly Asp Glu Asp Gly His Phe Pro Ala His Arg Glu 
385                 390                 395                 400 


Val Met Leu Ser Met Leu Met His Ser Ser Ser Lys Glu Val Phe Gln 
                405                 410                 415     


Ala Ser Ala Asn Ala Leu Ser Thr Leu Leu Glu Gln Asn Val Asn Phe 
            420                 425                 430         


Arg Lys Ile Leu Leu Ser Lys Gly Ile His Leu Asn Val Leu Glu Leu 
        435                 440                 445             


Met Gln Lys His Ile His Ser Pro Glu Val Ala Glu Ser Gly Cys Lys 
    450                 455                 460                 


Met Leu Asn His Leu Phe Glu Gly Ser Asn Thr Ser Leu Asp Ile Met 
465                 470                 475                 480 


Ala Ala Val Val Pro Lys Ile Leu Thr Val Met Lys Arg His Glu Thr 
                485                 490                 495     


Ser Leu Pro Val Gln Leu Glu Ala Leu Arg Ala Ile Leu His Phe Ile 
            500                 505                 510         


Val Pro Gly Met Pro Glu Glu Ser Arg Glu Asp Thr Glu Phe His His 
        515                 520                 525             


Lys Leu Asn Met Val Lys Lys Gln Cys Phe Lys Asn Asp Ile His Lys 
    530                 535                 540                 


Leu Val Leu Ala Ala Leu Asn Arg Phe Ile Gly Asn Pro Gly Ile Gln 
545                 550                 555                 560 


Lys Cys Gly Leu Lys Val Ile Ser Ser Ile Val His Phe Pro Asp Ala 
                565                 570                 575     


Leu Glu Met Leu Ser Leu Glu Gly Ala Met Asp Ser Val Leu His Thr 
            580                 585                 590         


Leu Gln Met Tyr Pro Asp Asp Gln Glu Ile Gln Cys Leu Gly Leu Ser 
        595                 600                 605             


Leu Ile Gly Tyr Leu Ile Thr Lys Lys Asn Val Phe Ile Gly Thr Gly 
    610                 615                 620                 


His Leu Leu Ala Lys Ile Leu Val Ser Ser Leu Tyr Arg Phe Lys Asp 
625                 630                 635                 640 


Val Ala Glu Ile Gln Thr Lys Gly Phe Gln Thr Ile Leu Ala Ile Leu 
                645                 650                 655     


Lys Leu Ser Ala Ser Phe Ser Lys Leu Leu Val His His Ser Phe Asp 
            660                 665                 670         


Leu Val Ile Phe His Gln Met Ser Ser Asn Ile Met Glu Gln Lys Asp 
        675                 680                 685             


Gln Gln Phe Leu Asn Leu Cys Cys Lys Cys Phe Ala Lys Val Ala Met 
    690                 695                 700                 


Asp Asp Tyr Leu Lys Asn Val Met Leu Glu Arg Ala Cys Asp Gln Asn 
705                 710                 715                 720 


Asn Ser Ile Met Val Glu Cys Leu Leu Leu Leu Gly Ala Asp Ala Asn 
                725                 730                 735     


Gln Ala Lys Glu Gly Ser Ser Leu Ile Cys Gln Val Cys Glu Lys Glu 
            740                 745                 750         


Ser Ser Pro Lys Leu Val Glu Leu Leu Leu Asn Ser Gly Ser Arg Glu 
        755                 760                 765             


Gln Asp Val Arg Lys Ala Leu Thr Ile Ser Ile Gly Lys Gly Asp Ser 
    770                 775                 780                 


Gln Ile Ile Ser Leu Leu Leu Arg Arg Leu Ala Leu Asp Val Ala Asn 
785                 790                 795                 800 


Asn Ser Ile Cys Leu Gly Gly Phe Cys Ile Gly Lys Val Glu Pro Ser 
                805                 810                 815     


Trp Leu Gly Pro Leu Phe Pro Asp Lys Thr Ser Asn Leu Arg Lys Gln 
            820                 825                 830         


Thr Asn Ile Ala Ser Thr Leu Ala Arg Met Val Ile Arg Tyr Gln Met 
        835                 840                 845             


Lys Ser Ala Val Glu Glu Gly Thr Ala Ser Gly Ser Asp Gly Asn Phe 
    850                 855                 860                 


Ser Glu Asp Val Leu Ser Lys Phe Asp Glu Trp Thr Phe Ile Pro Asp 
865                 870                 875                 880 


Ser Ser Met Asp Ser Val Phe Ala Gln Ser Asp Asp Leu Asp Ser Glu 
                885                 890                 895     


Gly Ser Glu Gly Ser Phe Leu Val Lys Lys Lys Ser Asn Ser Ile Ser 
            900                 905                 910         


Val Gly Glu Phe Tyr Arg Asp Ala Val Leu Gln Arg Cys Ser Pro Asn 
        915                 920                 925             


Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp His Glu Asp 
    930                 935                 940                 


Leu Leu Lys Arg Lys Arg Lys Ile Leu Ser Ser Asp Asp Ser Leu Arg 
945                 950                 955                 960 


Ser Ser Lys Leu Gln Ser His Met Arg His Ser Asp Ser Ile Ser Ser 
                965                 970                 975     


Leu Ala Ser Glu Arg Glu Tyr Ile Thr Ser Leu Asp Leu Ser Ala Asn 
            980                 985                 990         


Glu Leu Arg Asp Ile Asp Ala Leu  Ser Gln Lys Cys Cys  Ile Ser Val 
        995                 1000                 1005             


His Leu  Glu His Leu Glu Lys  Leu Glu Leu His Gln  Asn Ala Leu 
    1010                 1015                 1020             


Thr Ser  Phe Pro Gln Gln Leu  Cys Glu Thr Leu Lys  Ser Leu Thr 
    1025                 1030                 1035             


His Leu  Asp Leu His Ser Asn  Lys Phe Thr Ser Phe  Pro Ser Tyr 
    1040                 1045                 1050             


Leu Leu  Lys Met Ser Cys Ile  Ala Asn Leu Asp Val  Ser Arg Asn 
    1055                 1060                 1065             


Asp Ile  Gly Pro Ser Val Val  Leu Asp Pro Thr Val  Lys Cys Pro 
    1070                 1075                 1080             


Thr Leu  Lys Gln Phe Asn Leu  Ser Tyr Asn Gln Leu  Ser Phe Val 
    1085                 1090                 1095             


Pro Glu  Asn Leu Thr Asp Val  Val Glu Lys Leu Glu  Gln Leu Ile 
    1100                 1105                 1110             


Leu Glu  Gly Asn Lys Ile Ser  Gly Ile Cys Ser Pro  Leu Arg Leu 
    1115                 1120                 1125             


Lys Glu  Leu Lys Ile Leu Asn  Leu Ser Lys Asn His  Ile Ser Ser 
    1130                 1135                 1140             


Leu Ser  Glu Asn Phe Leu Glu  Ala Cys Pro Lys Val  Glu Ser Phe 
    1145                 1150                 1155             


Ser Ala  Arg Met Asn Phe Leu  Ala Ala Met Pro Phe  Leu Pro Pro 
    1160                 1165                 1170             


Ser Met  Thr Ile Leu Lys Leu  Ser Gln Asn Lys Phe  Ser Cys Ile 
    1175                 1180                 1185             


Pro Glu  Ala Ile Leu Asn Leu  Pro His Leu Arg Ser  Leu Asp Met 
    1190                 1195                 1200             


Ser Ser  Asn Asp Ile Gln Tyr  Leu Pro Gly Pro Ala  His Trp Lys 
    1205                 1210                 1215             


Ser Leu  Asn Leu Arg Glu Leu  Leu Phe Ser His Asn  Gln Ile Ser 
    1220                 1225                 1230             


Ile Leu  Asp Leu Ser Glu Lys  Ala Tyr Leu Trp Ser  Arg Val Glu 
    1235                 1240                 1245             


Lys Leu  His Leu Ser His Asn  Lys Leu Lys Glu Ile  Pro Pro Glu 
    1250                 1255                 1260             


Ile Gly  Cys Leu Glu Asn Leu  Thr Ser Leu Asp Val  Ser Tyr Asn 
    1265                 1270                 1275             


Leu Glu  Leu Arg Ser Phe Pro  Asn Glu Met Gly Lys  Leu Ser Lys 
    1280                 1285                 1290             


Ile Trp  Asp Leu Pro Leu Asp  Glu Leu His Leu Asn  Phe Asp Phe 
    1295                 1300                 1305             


Lys His  Ile Gly Cys Lys Ala  Lys Asp Ile Ile Arg  Phe Leu Gln 
    1310                 1315                 1320             


Gln Arg  Leu Lys Lys Ala Val  Pro Tyr Asn Arg Met  Lys Leu Met 
    1325                 1330                 1335             


Ile Val  Gly Asn Thr Gly Ser  Gly Lys Thr Thr Leu  Leu Gln Gln 
    1340                 1345                 1350             


Leu Met  Lys Thr Lys Lys Ser  Asp Leu Gly Met Gln  Ser Ala Thr 
    1355                 1360                 1365             


Val Gly  Ile Asp Val Lys Asp  Trp Pro Ile Gln Ile  Arg Asp Lys 
    1370                 1375                 1380             


Arg Lys  Arg Asp Leu Val Leu  Asn Val Trp Asp Phe  Ala Gly Arg 
    1385                 1390                 1395             


Glu Glu  Phe Tyr Ser Thr His  Pro His Phe Met Thr  Gln Arg Ala 
    1400                 1405                 1410             


Leu Tyr  Leu Ala Val Tyr Asp  Leu Ser Lys Gly Gln  Ala Glu Val 
    1415                 1420                 1425             


Asp Ala  Met Lys Pro Trp Leu  Phe Asn Ile Lys Ala  Arg Ala Ser 
    1430                 1435                 1440             


Ser Ser  Pro Val Ile Leu Val  Gly Thr His Leu Asp  Val Ser Asp 
    1445                 1450                 1455             


Glu Lys  Gln Arg Lys Ala Cys  Met Ser Lys Ile Thr  Lys Glu Leu 
    1460                 1465                 1470             


Leu Asn  Lys Arg Gly Phe Pro  Ala Ile Arg Asp Tyr  His Phe Val 
    1475                 1480                 1485             


Asn Ala  Thr Glu Glu Ser Asp  Ala Leu Ala Lys Leu  Arg Lys Thr 
    1490                 1495                 1500             


Ile Ile  Asn Glu Ser Leu Asn  Phe Lys Ile Arg Asp  Gln Leu Val 
    1505                 1510                 1515             


Val Gly  Gln Leu Ile Pro Asp  Cys Tyr Val Glu Leu  Glu Lys Ile 
    1520                 1525                 1530             


Ile Leu  Ser Glu Arg Lys Asn  Val Pro Ile Glu Phe  Pro Val Ile 
    1535                 1540                 1545             


Asp Arg  Lys Arg Leu Leu Gln  Leu Val Arg Glu Asn  Gln Leu Gln 
    1550                 1555                 1560             


Leu Asp  Glu Asn Glu Leu Pro  His Ala Val His Phe  Leu Asn Glu 
    1565                 1570                 1575             


Ser Gly  Val Leu Leu His Phe  Gln Asp Pro Ala Leu  Gln Leu Ser 
    1580                 1585                 1590             


Asp Leu  Tyr Phe Val Glu Pro  Lys Trp Leu Cys Lys  Ile Met Ala 
    1595                 1600                 1605             


Gln Ile  Leu Thr Val Lys Val  Glu Gly Cys Pro Lys  His Pro Lys 
    1610                 1615                 1620             


Gly Ile  Ile Ser Arg Arg Asp  Val Glu Lys Phe Leu  Ser Lys Lys 
    1625                 1630                 1635             


Arg Lys  Phe Pro Lys Asn Tyr  Met Ser Gln Tyr Phe  Lys Leu Leu 
    1640                 1645                 1650             


Glu Lys  Phe Gln Ile Ala Leu  Pro Ile Gly Glu Glu  Tyr Leu Leu 
    1655                 1660                 1665             


Val Pro  Ser Ser Leu Ser Asp  His Arg Pro Val Ile  Glu Leu Pro 
    1670                 1675                 1680             


His Cys  Glu Asn Ser Glu Ile  Ile Ile Arg Leu Tyr  Glu Met Pro 
    1685                 1690                 1695             


Tyr Phe  Pro Met Gly Phe Trp  Ser Arg Leu Ile Asn  Arg Leu Leu 
    1700                 1705                 1710             


Glu Ile  Ser Pro Tyr Met Leu  Ser Gly Arg Glu Arg  Ala Leu Arg 
    1715                 1720                 1725             


Pro Asn  Arg Met Tyr Trp Arg  Gln Gly Ile Tyr Leu  Asn Trp Ser 
    1730                 1735                 1740             


Pro Glu  Ala Tyr Cys Leu Val  Gly Ser Glu Val Leu  Asp Asn His 
    1745                 1750                 1755             


Pro Glu  Ser Phe Leu Lys Ile  Thr Val Pro Ser Cys  Arg Lys Gly 
    1760                 1765                 1770             


Cys Ile  Leu Leu Gly Gln Val  Val Asp His Ile Asp  Ser Leu Met 
    1775                 1780                 1785             


Glu Glu  Trp Phe Pro Gly Leu  Leu Glu Ile Asp Ile  Cys Gly Glu 
    1790                 1795                 1800             


Gly Glu  Thr Leu Leu Lys Lys  Trp Ala Leu Tyr Ser  Phe Asn Asp 
    1805                 1810                 1815             


Gly Glu  Glu His Gln Lys Ile  Leu Leu Asp Asp Leu  Met Lys Lys 
    1820                 1825                 1830             


Ala Glu  Glu Gly Asp Leu Leu  Val Asn Pro Asp Gln  Pro Arg Leu 
    1835                 1840                 1845             


Thr Ile  Pro Ile Ser Gln Ile  Ala Pro Asp Leu Ile  Leu Ala Asp 
    1850                 1855                 1860             


Leu Pro  Arg Asn Ile Met Leu  Asn Asn Asp Glu Leu  Glu Phe Glu 
    1865                 1870                 1875             


Gln Ala  Pro Glu Phe Leu Leu  Gly Asp Gly Ser Phe  Gly Ser Val 
    1880                 1885                 1890             


Tyr Arg  Ala Ala Tyr Glu Gly  Glu Glu Val Ala Val  Lys Ile Phe 
    1895                 1900                 1905             


Asn Lys  His Thr Ser Leu Arg  Leu Leu Arg Gln Glu  Leu Val Val 
    1910                 1915                 1920             


Leu Cys  His Leu His His Pro  Ser Leu Ile Ser Leu  Leu Ala Ala 
    1925                 1930                 1935             


Gly Ile  Arg Pro Arg Met Leu  Val Met Glu Leu Ala  Ser Lys Gly 
    1940                 1945                 1950             


Ser Leu  Asp Arg Leu Leu Gln  Gln Asp Lys Ala Ser  Leu Thr Arg 
    1955                 1960                 1965             


Thr Leu  Gln His Arg Ile Ala  Leu His Val Ala Asp  Gly Leu Arg 
    1970                 1975                 1980             


Tyr Leu  His Ser Ala Met Ile  Ile Tyr Arg Asp Leu  Lys Pro His 
    1985                 1990                 1995             


Asn Val  Leu Leu Phe Thr Leu  Tyr Pro Asn Ala Ala  Ile Ile Ala 
    2000                 2005                 2010             


Lys Ile  Ala Asp Tyr Gly Ile  Ala Gln Tyr Cys Cys  Arg Met Gly 
    2015                 2020                 2025             


Ile Lys  Thr Ser Glu Gly Thr  Pro Gly Phe Arg Ala  Pro Glu Val 
    2030                 2035                 2040             


Ala Arg  Gly Asn Val Ile Tyr  Asn Gln Gln Ala Asp  Val Tyr Ser 
    2045                 2050                 2055             


Phe Gly  Leu Leu Leu Tyr Asp  Ile Leu Thr Thr Gly  Gly Arg Ile 
    2060                 2065                 2070             


Val Glu  Gly Leu Lys Phe Pro  Asn Glu Phe Asp Glu  Leu Glu Ile 
    2075                 2080                 2085             


Gln Gly  Lys Leu Pro Asp Pro  Val Lys Glu Tyr Gly  Cys Ala Pro 
    2090                 2095                 2100             


Trp Pro  Met Val Glu Lys Leu  Ile Lys Gln Cys Leu  Lys Glu Asn 
    2105                 2110                 2115             


Pro Gln  Glu Arg Pro Thr Ser  Ala Gln Val Phe Asp  Ile Leu Asn 
    2120                 2125                 2130             


Ser Ala  Glu Leu Val Cys Leu  Thr Arg Arg Ile Leu  Leu Pro Lys 
    2135                 2140                 2145             


Asn Val  Ile Val Glu Cys Met  Val Ala Thr His His  Asn Ser Arg 
    2150                 2155                 2160             


Asn Ala  Ser Ile Trp Leu Gly  Cys Gly His Thr Asp  Arg Gly Gln 
    2165                 2170                 2175             


Leu Ser  Phe Leu Asp Leu Asn  Thr Glu Gly Tyr Thr  Ser Glu Glu 
    2180                 2185                 2190             


Val Ala  Asp Ser Arg Ile Leu  Cys Leu Ala Leu Val  His Leu Pro 
    2195                 2200                 2205             


Val Glu  Lys Glu Ser Trp Ile  Val Ser Gly Thr Gln  Ser Gly Thr 
    2210                 2215                 2220             


Leu Leu  Val Ile Asn Thr Glu  Asp Gly Lys Lys Arg  His Thr Leu 
    2225                 2230                 2235             


Glu Lys  Met Thr Asp Ser Val  Thr Cys Leu Tyr Cys  Asn Ser Phe 
    2240                 2245                 2250             


Ser Lys  Gln Ser Lys Gln Lys  Asn Phe Leu Leu Val  Gly Thr Ala 
    2255                 2260                 2265             


Asp Gly  Lys Leu Ala Ile Phe  Glu Asp Lys Thr Val  Lys Leu Lys 
    2270                 2275                 2280             


Gly Ala  Ala Pro Leu Lys Ile  Leu Asn Ile Gly Asn  Val Ser Thr 
    2285                 2290                 2295             


Pro Leu  Met Cys Leu Ser Glu  Ser Thr Asn Ser Thr  Glu Arg Asn 
    2300                 2305                 2310             


Val Met  Trp Gly Gly Cys Gly  Thr Lys Ile Phe Ser  Phe Ser Asn 
    2315                 2320                 2325             


Asp Phe  Thr Ile Gln Lys Leu  Ile Glu Thr Arg Thr  Ser Gln Leu 
    2330                 2335                 2340             


Phe Ser  Tyr Ala Ala Phe Ser  Asp Ser Asn Ile Ile  Thr Val Val 
    2345                 2350                 2355             


Val Asp  Thr Ala Leu Tyr Ile  Ala Lys Gln Asn Ser  Pro Val Val 
    2360                 2365                 2370             


Glu Val  Trp Asp Lys Lys Thr  Glu Lys Leu Cys Gly  Leu Ile Asp 
    2375                 2380                 2385             


Cys Val  His Phe Leu Arg Glu  Val Met Val Lys Glu  Asn Lys Glu 
    2390                 2395                 2400             


Ser Lys  His Lys Met Ser Tyr  Ser Gly Arg Val Lys  Thr Leu Cys 
    2405                 2410                 2415             


Leu Gln  Lys Asn Thr Ala Leu  Trp Ile Gly Thr Gly  Gly Gly His 
    2420                 2425                 2430             


Ile Leu  Leu Leu Asp Leu Ser  Thr Arg Arg Leu Ile  Arg Val Ile 
    2435                 2440                 2445             


Tyr Asn  Phe Cys Asn Ser Val  Arg Val Met Met Thr  Ala Gln Leu 
    2450                 2455                 2460             


Gly Ser  Leu Lys Asn Val Met  Leu Val Leu Gly Tyr  Asn Arg Lys 
    2465                 2470                 2475             


Asn Thr  Glu Gly Thr Gln Lys  Gln Lys Glu Ile Gln  Ser Cys Leu 
    2480                 2485                 2490             


Thr Val  Trp Asp Ile Asn Leu  Pro His Glu Val Gln  Asn Leu Glu 
    2495                 2500                 2505             


Lys His  Ile Glu Val Arg Lys  Glu Leu Ala Glu Lys  Met Arg Arg 
    2510                 2515                 2520             


Thr Ser  Val Glu 
    2525         


<210>  5
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  6
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  7
<211>  2102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Ala Ala Ala Pro Ala Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Cys Ser Gly Ser Gly Ser Ser Ala Ser Arg Gly Phe Tyr Phe 
            20                  25                  30          


Asn Thr Val Leu Ser Leu Ala Arg Ser Leu Ala Val Gln Arg Pro Ala 
        35                  40                  45              


Ser Leu Glu Lys Val Gln Lys Leu Leu Cys Met Cys Pro Val Asp Phe 
    50                  55                  60                  


His Gly Ile Phe Gln Leu Asp Glu Arg Arg Arg Asp Ala Val Ile Ala 
65                  70                  75                  80  


Leu Gly Ile Phe Leu Ile Glu Ser Asp Leu Gln His Lys Asp Cys Val 
                85                  90                  95      


Val Pro Tyr Leu Leu Arg Leu Leu Lys Gly Leu Pro Lys Val Tyr Trp 
            100                 105                 110         


Val Glu Glu Ser Thr Ala Arg Lys Gly Arg Gly Ala Leu Pro Val Ala 
        115                 120                 125             


Glu Ser Phe Ser Phe Cys Leu Val Thr Leu Leu Ser Asp Val Ala Tyr 
    130                 135                 140                 


Arg Asp Pro Ser Leu Arg Asp Glu Ile Leu Glu Val Leu Leu Gln Val 
145                 150                 155                 160 


Leu His Val Leu Leu Gly Met Cys Gln Ala Leu Glu Ile Gln Asp Lys 
                165                 170                 175     


Glu Tyr Leu Cys Lys Tyr Ala Ile Pro Cys Leu Ile Gly Ile Ser Arg 
            180                 185                 190         


Ala Phe Gly Arg Tyr Ser Asn Met Glu Glu Ser Leu Leu Ser Lys Leu 
        195                 200                 205             


Phe Pro Lys Ile Pro Pro His Ser Leu Arg Val Leu Glu Glu Leu Glu 
    210                 215                 220                 


Gly Val Arg Arg Arg Ser Phe Asn Asp Phe Arg Ser Ile Leu Pro Ser 
225                 230                 235                 240 


Asn Leu Leu Thr Val Cys Gln Glu Gly Thr Leu Lys Arg Lys Thr Ser 
                245                 250                 255     


Ser Val Ser Ser Ile Ser Gln Val Ser Pro Glu Arg Gly Met Pro Pro 
            260                 265                 270         


Pro Ser Ser Pro Gly Gly Ser Ala Phe His Tyr Phe Glu Ala Ser Cys 
        275                 280                 285             


Leu Pro Asp Gly Thr Ala Leu Glu Pro Glu Tyr Tyr Phe Ser Thr Ile 
    290                 295                 300                 


Ser Ser Ser Phe Ser Val Ser Pro Leu Phe Asn Gly Val Thr Tyr Lys 
305                 310                 315                 320 


Glu Phe Asn Ile Pro Leu Glu Met Leu Arg Glu Leu Leu Asn Leu Val 
                325                 330                 335     


Lys Lys Ile Val Glu Glu Ala Val Leu Lys Ser Leu Asp Ala Ile Val 
            340                 345                 350         


Ala Ser Val Met Glu Ala Asn Pro Ser Ala Asp Leu Tyr Tyr Thr Ser 
        355                 360                 365             


Phe Ser Asp Pro Leu Tyr Leu Thr Met Phe Lys Met Leu Arg Asp Thr 
    370                 375                 380                 


Leu Tyr Tyr Met Lys Asp Leu Pro Thr Ser Phe Val Lys Glu Ile His 
385                 390                 395                 400 


Asp Phe Val Leu Glu Gln Phe Asn Thr Ser Gln Gly Glu Leu Gln Lys 
                405                 410                 415     


Ile Leu His Asp Ala Asp Arg Ile His Asn Glu Leu Ser Pro Leu Lys 
            420                 425                 430         


Leu Arg Cys Gln Ala Asn Ala Ala Cys Val Asp Leu Met Val Trp Ala 
        435                 440                 445             


Val Lys Asp Glu Gln Gly Ala Glu Asn Leu Cys Ile Lys Leu Ser Glu 
    450                 455                 460                 


Lys Leu Gln Ser Lys Thr Ser Ser Lys Val Ile Ile Ala His Leu Pro 
465                 470                 475                 480 


Leu Leu Ile Cys Cys Leu Gln Gly Leu Gly Arg Leu Cys Glu Arg Phe 
                485                 490                 495     


Pro Val Val Val His Ser Val Thr Pro Ser Leu Arg Asp Phe Leu Val 
            500                 505                 510         


Ile Pro Ser Pro Val Leu Val Lys Leu Tyr Lys Tyr His Ser Gln Tyr 
        515                 520                 525             


His Thr Val Ala Gly Asn Asp Ile Lys Ile Ser Val Thr Asn Glu His 
    530                 535                 540                 


Ser Glu Ser Thr Leu Asn Val Met Ser Gly Lys Lys Ser Gln Pro Ser 
545                 550                 555                 560 


Met Tyr Glu Gln Leu Arg Asp Ile Ala Ile Asp Asn Ile Cys Arg Cys 
                565                 570                 575     


Leu Lys Ala Gly Leu Thr Val Asp Pro Val Ile Val Glu Ala Phe Leu 
            580                 585                 590         


Ala Ser Leu Ser Asn Arg Leu Tyr Ile Ser Gln Glu Ser Asp Lys Asp 
        595                 600                 605             


Ala His Leu Ile Pro Asp His Thr Ile Arg Ala Leu Gly His Ile Ala 
    610                 615                 620                 


Val Ala Leu Arg Asp Thr Pro Lys Val Met Glu Pro Ile Leu Gln Ile 
625                 630                 635                 640 


Leu Gln Gln Lys Phe Cys Gln Pro Pro Ser Pro Leu Asp Val Leu Ile 
                645                 650                 655     


Ile Asp Gln Leu Gly Cys Leu Val Ile Thr Gly Asn Gln Tyr Ile Tyr 
            660                 665                 670         


Gln Glu Val Trp Asn Leu Phe Gln Gln Ile Ser Val Lys Ala Ser Ser 
        675                 680                 685             


Val Val Tyr Ser Ala Thr Lys Asp Tyr Lys Asp His Gly Tyr Arg His 
    690                 695                 700                 


Cys Ser Leu Ala Val Ile Asn Ala Leu Ala Asn Ile Ala Ala Asn Ile 
705                 710                 715                 720 


Gln Asp Glu His Leu Val Asp Glu Leu Leu Met Asn Leu Leu Glu Leu 
                725                 730                 735     


Phe Val Gln Leu Gly Leu Glu Gly Lys Arg Ala Ser Glu Arg Ala Ser 
            740                 745                 750         


Glu Lys Gly Pro Ala Leu Lys Ala Ser Ser Ser Ala Gly Asn Leu Gly 
        755                 760                 765             


Val Leu Ile Pro Val Ile Ala Val Leu Thr Arg Arg Leu Pro Pro Ile 
    770                 775                 780                 


Lys Glu Ala Lys Pro Arg Leu Gln Lys Leu Phe Arg Asp Phe Trp Leu 
785                 790                 795                 800 


Tyr Ser Val Leu Met Gly Phe Ala Val Glu Gly Ser Gly Leu Trp Pro 
                805                 810                 815     


Glu Glu Trp Tyr Glu Gly Val Cys Glu Ile Ala Thr Lys Ser Pro Leu 
            820                 825                 830         


Leu Thr Phe Pro Ser Lys Glu Pro Leu Arg Ser Val Leu Gln Tyr Asn 
        835                 840                 845             


Ser Ala Met Lys Asn Asp Thr Val Thr Pro Ala Glu Leu Ser Glu Leu 
    850                 855                 860                 


Arg Ser Thr Ile Ile Asn Leu Leu Asp Pro Pro Pro Glu Val Ser Ala 
865                 870                 875                 880 


Leu Ile Asn Lys Leu Asp Phe Ala Met Ser Thr Tyr Leu Leu Ser Val 
                885                 890                 895     


Tyr Arg Leu Glu Tyr Met Arg Val Leu Arg Ser Thr Asp Pro Asp Arg 
            900                 905                 910         


Phe Gln Val Met Phe Cys Tyr Phe Glu Asp Lys Ala Ile Gln Lys Asp 
        915                 920                 925             


Lys Ser Gly Met Met Gln Cys Val Ile Ala Val Ala Asp Lys Val Phe 
    930                 935                 940                 


Asp Ala Phe Leu Asn Met Met Ala Asp Lys Ala Lys Thr Lys Glu Asn 
945                 950                 955                 960 


Glu Glu Glu Leu Glu Arg His Ala Gln Phe Leu Leu Val Asn Phe Asn 
                965                 970                 975     


His Ile His Lys Arg Ile Arg Arg Val Ala Asp Lys Tyr Leu Ser Gly 
            980                 985                 990         


Leu Val Asp Lys Phe Pro His Leu  Leu Trp Ser Gly Thr  Val Leu Lys 
        995                 1000                 1005             


Thr Met  Leu Asp Ile Leu Gln  Thr Leu Ser Leu Ser  Leu Ser Ala 
    1010                 1015                 1020             


Asp Ile  His Lys Asp Gln Pro  Tyr Tyr Asp Ile Pro  Asp Ala Pro 
    1025                 1030                 1035             


Tyr Arg  Ile Thr Val Pro Asp  Thr Tyr Glu Ala Arg  Glu Ser Ile 
    1040                 1045                 1050             


Val Lys  Asp Phe Ala Ala Arg  Cys Gly Met Ile Leu  Gln Glu Ala 
    1055                 1060                 1065             


Met Lys  Trp Ala Pro Thr Val  Thr Lys Ser His Leu  Gln Glu Tyr 
    1070                 1075                 1080             


Leu Asn  Lys His Gln Asn Trp  Val Ser Gly Leu Ser  Gln His Thr 
    1085                 1090                 1095             


Gly Leu  Ala Met Ala Thr Glu  Ser Ile Leu His Phe  Ala Gly Tyr 
    1100                 1105                 1110             


Asn Lys  Gln Asn Thr Thr Leu  Gly Ala Thr Gln Leu  Ser Glu Arg 
    1115                 1120                 1125             


Pro Ala  Cys Val Lys Lys Asp  Tyr Ser Asn Phe Met  Ala Ser Leu 
    1130                 1135                 1140             


Asn Leu  Arg Asn Arg Tyr Ala  Gly Glu Val Tyr Gly  Met Ile Arg 
    1145                 1150                 1155             


Phe Ser  Gly Thr Thr Gly Gln  Met Ser Asp Leu Asn  Lys Met Met 
    1160                 1165                 1170             


Val Gln  Asp Leu His Ser Ala  Leu Asp Arg Ser His  Pro Gln His 
    1175                 1180                 1185             


Tyr Thr  Gln Ala Met Phe Lys  Leu Thr Ala Met Leu  Ile Ser Ser 
    1190                 1195                 1200             


Lys Asp  Cys Asp Pro Gln Leu  Leu His His Leu Cys  Trp Gly Pro 
    1205                 1210                 1215             


Leu Arg  Met Phe Asn Glu His  Gly Met Glu Thr Ala  Leu Ala Cys 
    1220                 1225                 1230             


Trp Glu  Trp Leu Leu Ala Gly  Lys Asp Gly Val Glu  Val Pro Phe 
    1235                 1240                 1245             


Met Arg  Glu Met Ala Gly Ala  Trp His Met Thr Val  Glu Gln Lys 
    1250                 1255                 1260             


Phe Gly  Leu Phe Ser Ala Glu  Ile Lys Glu Ala Asp  Pro Leu Ala 
    1265                 1270                 1275             


Ala Ser  Glu Ala Ser Gln Pro  Lys Pro Cys Pro Pro  Glu Val Thr 
    1280                 1285                 1290             


Pro His  Tyr Ile Trp Ile Asp  Phe Leu Val Gln Arg  Phe Glu Ile 
    1295                 1300                 1305             


Ala Lys  Tyr Cys Ser Ser Asp  Gln Val Glu Ile Phe  Ser Ser Leu 
    1310                 1315                 1320             


Leu Gln  Arg Ser Met Ser Leu  Asn Ile Gly Gly Ala  Lys Gly Ser 
    1325                 1330                 1335             


Met Asn  Arg His Val Ala Ala  Ile Gly Pro Arg Phe  Lys Leu Leu 
    1340                 1345                 1350             


Thr Leu  Gly Leu Ser Leu Leu  His Ala Asp Val Val  Pro Asn Ala 
    1355                 1360                 1365             


Thr Ile  Arg Asn Val Leu Arg  Glu Lys Ile Tyr Ser  Thr Ala Phe 
    1370                 1375                 1380             


Asp Tyr  Phe Ser Cys Pro Pro  Lys Phe Pro Thr Gln  Gly Glu Lys 
    1385                 1390                 1395             


Arg Leu  Arg Glu Asp Ile Ser  Ile Met Ile Lys Phe  Trp Thr Ala 
    1400                 1405                 1410             


Met Phe  Ser Asp Lys Lys Tyr  Leu Thr Ala Ser Gln  Leu Val Pro 
    1415                 1420                 1425             


Pro Asp  Asn Gln Asp Thr Arg  Ser Asn Leu Asp Ile  Thr Val Gly 
    1430                 1435                 1440             


Ser Arg  Gln Gln Ala Thr Gln  Gly Trp Ile Asn Thr  Tyr Pro Leu 
    1445                 1450                 1455             


Ser Ser  Gly Met Ser Thr Ile  Ser Lys Lys Ser Gly  Met Ser Lys 
    1460                 1465                 1470             


Lys Thr  Asn Arg Gly Ser Gln  Leu His Lys Tyr Tyr  Met Lys Arg 
    1475                 1480                 1485             


Arg Thr  Leu Leu Leu Ser Leu  Leu Ala Thr Glu Ile  Glu Arg Leu 
    1490                 1495                 1500             


Ile Thr  Trp Tyr Asn Pro Leu  Ser Ala Pro Glu Leu  Glu Leu Asp 
    1505                 1510                 1515             


Gln Ala  Gly Glu Asn Ser Val  Ala Asn Trp Arg Ser  Lys Tyr Ile 
    1520                 1525                 1530             


Ser Leu  Ser Glu Lys Gln Trp  Lys Asp Asn Val Asn  Leu Ala Trp 
    1535                 1540                 1545             


Ser Ile  Ser Pro Tyr Leu Ala  Val Gln Leu Pro Ala  Arg Phe Lys 
    1550                 1555                 1560             


Asn Thr  Glu Ala Ile Gly Asn  Glu Val Thr Arg Leu  Val Arg Leu 
    1565                 1570                 1575             


Asp Pro  Gly Ala Val Ser Asp  Val Pro Glu Ala Ile  Lys Phe Leu 
    1580                 1585                 1590             


Val Thr  Trp His Thr Ile Asp  Ala Asp Ala Pro Glu  Leu Ser His 
    1595                 1600                 1605             


Val Leu  Cys Trp Ala Pro Thr  Asp Pro Pro Thr Gly  Leu Ser Tyr 
    1610                 1615                 1620             


Phe Ser  Ser Met Tyr Pro Pro  His Pro Leu Thr Ala  Gln Tyr Gly 
    1625                 1630                 1635             


Val Lys  Val Leu Arg Ser Phe  Pro Pro Asp Ala Ile  Leu Phe Tyr 
    1640                 1645                 1650             


Ile Pro  Gln Ile Val Gln Ala  Leu Arg Tyr Asp Lys  Met Gly Tyr 
    1655                 1660                 1665             


Val Arg  Glu Tyr Ile Leu Trp  Ala Ala Ser Lys Ser  Gln Leu Leu 
    1670                 1675                 1680             


Ala His  Gln Phe Ile Trp Asn  Met Lys Thr Asn Ile  Tyr Leu Asp 
    1685                 1690                 1695             


Glu Glu  Gly His Gln Lys Asp  Pro Asp Ile Gly Asp  Leu Leu Asp 
    1700                 1705                 1710             


Gln Leu  Val Glu Glu Ile Thr  Gly Ser Leu Ser Gly  Pro Ala Lys 
    1715                 1720                 1725             


Asp Phe  Tyr Gln Arg Glu Phe  Asp Phe Phe Asn Lys  Ile Thr Asn 
    1730                 1735                 1740             


Val Ser  Ala Ile Ile Lys Pro  Tyr Pro Lys Gly Asp  Glu Arg Lys 
    1745                 1750                 1755             


Lys Ala  Cys Leu Ser Ala Leu  Ser Glu Val Lys Val  Gln Pro Gly 
    1760                 1765                 1770             


Cys Tyr  Leu Pro Ser Asn Pro  Glu Ala Ile Val Leu  Asp Ile Asp 
    1775                 1780                 1785             


Tyr Lys  Ser Gly Thr Pro Met  Gln Ser Ala Ala Lys  Ala Pro Tyr 
    1790                 1795                 1800             


Leu Ala  Lys Phe Lys Val Lys  Arg Cys Gly Val Ser  Glu Leu Glu 
    1805                 1810                 1815             


Lys Glu  Gly Leu Arg Cys Arg  Ser Asp Ser Glu Asp  Glu Cys Ser 
    1820                 1825                 1830             


Thr Gln  Glu Ala Asp Gly Gln  Lys Ile Ser Trp Gln  Ala Ala Ile 
    1835                 1840                 1845             


Phe Lys  Val Gly Asp Asp Cys  Arg Gln Asp Met Leu  Ala Leu Gln 
    1850                 1855                 1860             


Ile Ile  Asp Leu Phe Lys Asn  Ile Phe Gln Leu Val  Gly Leu Asp 
    1865                 1870                 1875             


Leu Phe  Val Phe Pro Tyr Arg  Val Val Ala Thr Ala  Pro Gly Cys 
    1880                 1885                 1890             


Gly Val  Ile Glu Cys Ile Pro  Asp Cys Thr Ser Arg  Asp Gln Leu 
    1895                 1900                 1905             


Gly Arg  Gln Thr Asp Phe Gly  Met Tyr Asp Tyr Phe  Thr Arg Gln 
    1910                 1915                 1920             


Tyr Gly  Asp Glu Ser Thr Leu  Ala Phe Gln Gln Ala  Arg Tyr Asn 
    1925                 1930                 1935             


Phe Ile  Arg Ser Met Ala Ala  Tyr Ser Leu Leu Leu  Phe Leu Leu 
    1940                 1945                 1950             


Gln Ile  Lys Asp Arg His Asn  Gly Asn Ile Met Leu  Asp Lys Lys 
    1955                 1960                 1965             


Gly His  Ile Ile His Ile Asp  Phe Gly Phe Met Phe  Glu Ser Ser 
    1970                 1975                 1980             


Pro Gly  Gly Asn Leu Gly Trp  Glu Pro Asp Ile Lys  Leu Thr Asp 
    1985                 1990                 1995             


Glu Met  Val Met Ile Met Gly  Gly Lys Met Glu Ala  Thr Pro Phe 
    2000                 2005                 2010             


Lys Trp  Phe Met Glu Met Cys  Val Arg Gly Tyr Leu  Ala Val Arg 
    2015                 2020                 2025             


Pro Tyr  Met Asp Ala Val Val  Ser Leu Val Thr Leu  Met Leu Asp 
    2030                 2035                 2040             


Thr Gly  Leu Pro Cys Phe Arg  Gly Gln Thr Ile Lys  Leu Leu Lys 
    2045                 2050                 2055             


His Arg  Phe Ser Pro Asn Met  Thr Glu Arg Glu Ala  Ala Asn Phe 
    2060                 2065                 2070             


Ile Met  Lys Val Ile Gln Ser  Cys Phe Leu Ser Asn  Arg Ser Arg 
    2075                 2080                 2085             


Thr Tyr  Asp Met Ile Gln Tyr  Tyr Gln Asn Asp Ile  Pro Tyr 
    2090                 2095                 2100         


<210>  8
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Ala Ser Ala Ser Ser Gly Pro Ser Ser Ser Val Gly Phe Ser Ser 
1               5                   10                  15      


Phe Asp Pro Ala Val Pro Ser Cys Thr Leu Ser Ser Ala Ala Ser Gly 
            20                  25                  30          


Ile Lys Arg Pro Met Ala Ser Glu Val Leu Glu Ala Arg Gln Asp Ser 
        35                  40                  45              


Tyr Ile Ser Leu Val Pro Tyr Ala Ser Gly Met Pro Ile Lys Lys Ile 
    50                  55                  60                  


Gly His Arg Ser Val Asp Ser Ser Gly Glu Thr Thr Tyr Lys Lys Thr 
65                  70                  75                  80  


Thr Ser Ser Ala Leu Lys Gly Ala Ile Gln Leu Gly Ile Thr His Thr 
                85                  90                  95      


Val Gly Ser Leu Ser Thr Lys Pro Glu Arg Asp Val Leu Met Gln Asp 
            100                 105                 110         


Phe Tyr Val Val Glu Ser Ile Phe Phe Pro Ser Glu Gly Ser Asn Leu 
        115                 120                 125             


Thr Pro Ala His His Tyr Asn Asp Phe Arg Phe Lys Thr Tyr Ala Pro 
    130                 135                 140                 


Val Ala Phe Arg Tyr Phe Arg Glu Leu Phe Gly Ile Arg Pro Asp Asp 
145                 150                 155                 160 


Tyr Leu Tyr Ser Leu Cys Ser Glu Pro Leu Ile Glu Leu Cys Ser Ser 
                165                 170                 175     


Gly Ala Ser Gly Ser Leu Phe Tyr Val Ser Ser Asp Asp Glu Phe Ile 
            180                 185                 190         


Ile Lys Thr Val Gln His Lys Glu Ala Glu Phe Leu Gln Lys Leu Leu 
        195                 200                 205             


Pro Gly Tyr Tyr Met Asn Leu Asn Gln Asn Pro Arg Thr Leu Leu Pro 
    210                 215                 220                 


Lys Phe Tyr Gly Leu Tyr Cys Val Gln Ala Gly Gly Lys Asn Ile Arg 
225                 230                 235                 240 


Ile Val Val Met Asn Asn Leu Leu Pro Arg Ser Val Lys Met His Ile 
                245                 250                 255     


Lys Tyr Asp Leu Lys Gly Ser Thr Tyr Lys Arg Arg Ala Ser Gln Lys 
            260                 265                 270         


Glu Arg Glu Lys Pro Leu Pro Thr Phe Lys Asp Leu Asp Phe Leu Gln 
        275                 280                 285             


Asp Ile Pro Asp Gly Leu Phe Leu Asp Ala Asp Met Tyr Asn Ala Leu 
    290                 295                 300                 


Cys Lys Thr Leu Gln Arg Asp Cys Leu Val Leu Gln Ser Phe Lys Ile 
305                 310                 315                 320 


Met Asp Tyr Ser Leu Leu Met Ser Ile His Asn Ile Asp His Ala Gln 
                325                 330                 335     


Arg Glu Pro Leu Ser Ser Glu Thr Gln Tyr Ser Val Asp Thr Arg Arg 
            340                 345                 350         


Pro Ala Pro Gln Lys Ala Leu Tyr Ser Thr Ala Met Glu Ser Ile Gln 
        355                 360                 365             


Gly Glu Ala Arg Arg Gly Gly Thr Met Glu Thr Asp Asp His Met Gly 
    370                 375                 380                 


Gly Ile Pro Ala Arg Asn Ser Lys Gly Glu Arg Leu Leu Leu Tyr Ile 
385                 390                 395                 400 


Gly Ile Ile Asp Ile Leu Gln Ser Tyr Arg Phe Val Lys Lys Leu Glu 
                405                 410                 415     


His Ser Trp Lys Ala Leu Val His Asp Gly Asp Thr Val Ser Val His 
            420                 425                 430         


Arg Pro Gly Phe Tyr Ala Glu Arg Phe Gln Arg Phe Met Cys Asn Thr 
        435                 440                 445             


Val Phe Lys Lys Ile Pro Leu Lys Pro Ser Pro Ser Lys Lys Phe Arg 
    450                 455                 460                 


Ser Gly Ser Ser Phe Ser Arg Arg Ala Gly Ser Ser Gly Asn Ser Cys 
465                 470                 475                 480 


Ile Thr Tyr Gln Pro Ser Val Ser Gly Glu His Lys Ala Gln Val Thr 
                485                 490                 495     


Thr Lys Ala Glu Val Glu Pro Gly Val His Leu Gly Arg Pro Asp Val 
            500                 505                 510         


Leu Pro Gln Thr Pro Pro Leu Glu Glu Ile Ser Glu Gly Ser Pro Ile 
        515                 520                 525             


Pro Asp Pro Ser Phe Ser Pro Leu Val Gly Glu Thr Leu Gln Met Leu 
    530                 535                 540                 


Thr Thr Ser Thr Thr Leu Glu Lys Leu Glu Val Ala Glu Ser Glu Phe 
545                 550                 555                 560 


Thr His 
        


<210>  9
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Gly Lys Lys Ser Arg Val Lys Thr Gln Lys Ser Gly Thr Gly Ala 
1               5                   10                  15      


Thr Ala Thr Val Ser Pro Lys Glu Ile Leu Asn Leu Thr Ser Glu Leu 
            20                  25                  30          


Leu Gln Lys Cys Ser Ser Pro Ala Pro Gly Pro Gly Lys Glu Trp Glu 
        35                  40                  45              


Glu Tyr Val Gln Ile Arg Thr Leu Val Glu Lys Ile Arg Lys Lys Gln 
    50                  55                  60                  


Lys Gly Leu Ser Val Thr Phe Asp Gly Lys Arg Glu Asp Tyr Phe Pro 
65                  70                  75                  80  


Asp Leu Met Lys Trp Ala Ser Glu Asn Gly Ala Ser Val Glu Gly Phe 
                85                  90                  95      


Glu Met Val Asn Phe Lys Glu Glu Gly Phe Gly Leu Arg Ala Thr Arg 
            100                 105                 110         


Asp Ile Lys Ala Glu Glu Leu Phe Leu Trp Val Pro Arg Lys Leu Leu 
        115                 120                 125             


Met Thr Val Glu Ser Ala Lys Asn Ser Val Leu Gly Pro Leu Tyr Ser 
    130                 135                 140                 


Gln Asp Arg Ile Leu Gln Ala Met Gly Asn Ile Ala Leu Ala Phe His 
145                 150                 155                 160 


Leu Leu Cys Glu Arg Ala Ser Pro Asn Ser Phe Trp Gln Pro Tyr Ile 
                165                 170                 175     


Gln Thr Leu Pro Ser Glu Tyr Asp Thr Pro Leu Tyr Phe Glu Glu Asp 
            180                 185                 190         


Glu Val Arg Tyr Leu Gln Ser Thr Gln Ala Ile His Asp Val Phe Ser 
        195                 200                 205             


Gln Tyr Lys Asn Thr Ala Arg Gln Tyr Ala Tyr Phe Tyr Lys Val Ile 
    210                 215                 220                 


Gln Thr His Pro His Ala Asn Lys Leu Pro Leu Lys Asp Ser Phe Thr 
225                 230                 235                 240 


Tyr Glu Asp Tyr Arg Trp Ala Val Ser Ser Val Met Thr Arg Gln Asn 
                245                 250                 255     


Gln Ile Pro Thr Glu Asp Gly Ser Arg Val Thr Leu Ala Leu Ile Pro 
            260                 265                 270         


Leu Trp Asp Met Cys Asn His Thr Asn Gly Leu Ile Thr Thr Gly Tyr 
        275                 280                 285             


Asn Leu Glu Asp Asp Arg Cys Glu Cys Val Ala Leu Gln Asp Phe Arg 
    290                 295                 300                 


Ala Gly Glu Gln Ile Tyr Ile Phe Tyr Gly Thr Arg Ser Asn Ala Glu 
305                 310                 315                 320 


Phe Val Ile His Ser Gly Phe Phe Phe Asp Asn Asn Ser His Asp Arg 
                325                 330                 335     


Val Lys Ile Lys Leu Gly Val Ser Lys Ser Asp Arg Leu Tyr Ala Met 
            340                 345                 350         


Lys Ala Glu Val Leu Ala Arg Ala Gly Ile Pro Thr Ser Ser Val Phe 
        355                 360                 365             


Ala Leu His Phe Thr Glu Pro Pro Ile Ser Ala Gln Leu Leu Ala Phe 
    370                 375                 380                 


Leu Arg Val Phe Cys Met Thr Glu Glu Glu Leu Lys Glu His Leu Leu 
385                 390                 395                 400 


Gly Asp Ser Ala Ile Asp Arg Ile Phe Thr Leu Gly Asn Ser Glu Phe 
                405                 410                 415     


Pro Val Ser Trp Asp Asn Glu Val Lys Leu Trp Thr Phe Leu Glu Asp 
            420                 425                 430         


Arg Ala Ser Leu Leu Leu Lys Thr Tyr Lys Thr Thr Ile Glu Glu Asp 
        435                 440                 445             


Lys Ser Val Leu Lys Asn His Asp Leu Ser Val Arg Ala Lys Met Ala 
    450                 455                 460                 


Ile Lys Leu Arg Leu Gly Glu Lys Glu Ile Leu Glu Lys Ala Val Lys 
465                 470                 475                 480 


Ser Ala Ala Val Asn Arg Glu Tyr Tyr Arg Gln Gln Met Glu Glu Lys 
                485                 490                 495     


Ala Pro Leu Pro Lys Tyr Glu Glu Ser Asn Leu Gly Leu Leu Glu Ser 
            500                 505                 510         


Ser Val Gly Asp Ser Arg Leu Pro Leu Val Leu Arg Asn Leu Glu Glu 
        515                 520                 525             


Glu Ala Gly Val Gln Asp Ala Leu Asn Ile Arg Glu Ala Ile Ser Lys 
    530                 535                 540                 


Ala Lys Ala Thr Glu Asn Gly Leu Val Asn Gly Glu Asn Ser Ile Pro 
545                 550                 555                 560 


Asn Gly Thr Arg Ser Glu Asn Glu Ser Leu Asn Gln Glu Ser Lys Arg 
                565                 570                 575     


Ala Val Glu Asp Ala Lys Gly Ser Ser Ser Asp Ser Thr Ala Gly Val 
            580                 585                 590         


Lys Glu 
        


<210>  10
<211>  3859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Ala Phe Val Ala Thr Gln Gly Ala Thr Val Val Asp Gln Thr Thr 
1               5                   10                  15      


Leu Met Lys Lys Tyr Leu Gln Phe Val Ala Ala Leu Thr Asp Val Asn 
            20                  25                  30          


Thr Pro Asp Glu Thr Lys Leu Lys Met Met Gln Glu Val Ser Glu Asn 
        35                  40                  45              


Phe Glu Asn Val Thr Ser Ser Pro Gln Tyr Ser Thr Phe Leu Glu His 
    50                  55                  60                  


Ile Ile Pro Arg Phe Leu Thr Phe Leu Gln Asp Gly Glu Val Gln Phe 
65                  70                  75                  80  


Leu Gln Glu Lys Pro Ala Gln Gln Leu Arg Lys Leu Val Leu Glu Ile 
                85                  90                  95      


Ile His Arg Ile Pro Thr Asn Glu His Leu Arg Pro His Thr Lys Asn 
            100                 105                 110         


Val Leu Ser Val Met Phe Arg Phe Leu Glu Thr Glu Asn Glu Glu Asn 
        115                 120                 125             


Val Leu Ile Cys Leu Arg Ile Ile Ile Glu Leu His Lys Gln Phe Arg 
    130                 135                 140                 


Pro Pro Ile Thr Gln Glu Ile His His Phe Leu Asp Phe Val Lys Gln 
145                 150                 155                 160 


Ile Tyr Lys Glu Leu Pro Lys Val Val Asn Arg Tyr Phe Glu Asn Pro 
                165                 170                 175     


Gln Val Ile Pro Glu Asn Thr Val Pro Pro Pro Glu Met Val Gly Met 
            180                 185                 190         


Ile Thr Thr Ile Ala Val Lys Val Asn Pro Glu Arg Glu Asp Ser Glu 
        195                 200                 205             


Thr Arg Thr His Ser Ile Ile Pro Arg Gly Ser Leu Ser Leu Lys Val 
    210                 215                 220                 


Leu Ala Glu Leu Pro Ile Ile Val Val Leu Met Tyr Gln Leu Tyr Lys 
225                 230                 235                 240 


Leu Asn Ile His Asn Val Val Ala Glu Phe Val Pro Leu Ile Met Asn 
                245                 250                 255     


Thr Ile Ala Ile Gln Val Ser Ala Gln Ala Arg Gln His Lys Leu Tyr 
            260                 265                 270         


Asn Lys Glu Leu Tyr Ala Asp Phe Ile Ala Ala Gln Ile Lys Thr Leu 
        275                 280                 285             


Ser Phe Leu Ala Tyr Ile Ile Arg Ile Tyr Gln Glu Leu Val Thr Lys 
    290                 295                 300                 


Tyr Ser Gln Gln Met Val Lys Gly Met Leu Gln Leu Leu Ser Asn Cys 
305                 310                 315                 320 


Pro Ala Glu Thr Ala His Leu Arg Lys Glu Leu Leu Ile Ala Ala Lys 
                325                 330                 335     


His Ile Leu Thr Thr Glu Leu Arg Asn Gln Phe Ile Pro Cys Met Asp 
            340                 345                 350         


Lys Leu Phe Asp Glu Ser Ile Leu Ile Gly Ser Gly Tyr Thr Ala Arg 
        355                 360                 365             


Glu Thr Leu Arg Pro Leu Ala Tyr Ser Thr Leu Ala Asp Leu Val His 
    370                 375                 380                 


His Val Arg Gln His Leu Pro Leu Ser Asp Leu Ser Leu Ala Val Gln 
385                 390                 395                 400 


Leu Phe Ala Lys Asn Ile Asp Asp Glu Ser Leu Pro Ser Ser Ile Gln 
                405                 410                 415     


Thr Met Ser Cys Lys Leu Leu Leu Asn Leu Val Asp Cys Ile Arg Ser 
            420                 425                 430         


Lys Ser Glu Gln Glu Ser Gly Asn Gly Arg Asp Val Leu Met Arg Met 
        435                 440                 445             


Leu Glu Val Phe Val Leu Lys Phe His Thr Ile Ala Arg Tyr Gln Leu 
    450                 455                 460                 


Ser Ala Ile Phe Lys Lys Cys Lys Pro Gln Ser Glu Leu Gly Ala Val 
465                 470                 475                 480 


Glu Ala Ala Leu Pro Gly Val Pro Thr Ala Pro Ala Ala Pro Gly Pro 
                485                 490                 495     


Ala Pro Ser Pro Ala Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro 
            500                 505                 510         


Pro Pro Pro Ala Thr Pro Val Thr Pro Ala Pro Val Pro Pro Phe Glu 
        515                 520                 525             


Lys Gln Gly Glu Lys Asp Lys Glu Asp Lys Gln Thr Phe Gln Val Thr 
    530                 535                 540                 


Asp Cys Arg Ser Leu Val Lys Thr Leu Val Cys Gly Val Lys Thr Ile 
545                 550                 555                 560 


Thr Trp Gly Ile Thr Ser Cys Lys Ala Pro Gly Glu Ala Gln Phe Ile 
                565                 570                 575     


Pro Asn Lys Gln Leu Gln Pro Lys Glu Thr Gln Ile Tyr Ile Lys Leu 
            580                 585                 590         


Val Lys Tyr Ala Met Gln Ala Leu Asp Ile Tyr Gln Val Gln Ile Ala 
        595                 600                 605             


Gly Asn Gly Gln Thr Tyr Ile Arg Val Ala Asn Cys Gln Thr Val Arg 
    610                 615                 620                 


Met Lys Glu Glu Lys Glu Val Leu Glu His Phe Ala Gly Val Phe Thr 
625                 630                 635                 640 


Met Met Asn Pro Leu Thr Phe Lys Glu Ile Phe Gln Thr Thr Val Pro 
                645                 650                 655     


Tyr Met Val Glu Arg Ile Ser Lys Asn Tyr Ala Leu Gln Ile Val Ala 
            660                 665                 670         


Asn Ser Phe Leu Ala Asn Pro Thr Thr Ser Ala Leu Phe Ala Thr Ile 
        675                 680                 685             


Leu Val Glu Tyr Leu Leu Asp Arg Leu Pro Glu Met Gly Ser Asn Val 
    690                 695                 700                 


Glu Leu Ser Asn Leu Tyr Leu Lys Leu Phe Lys Leu Val Phe Gly Ser 
705                 710                 715                 720 


Val Ser Leu Phe Ala Ala Glu Asn Glu Gln Met Leu Lys Pro His Leu 
                725                 730                 735     


His Lys Ile Val Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu 
            740                 745                 750         


Pro Tyr Asn Tyr Phe Leu Leu Leu Arg Ala Leu Phe Arg Ser Ile Gly 
        755                 760                 765             


Gly Gly Ser His Asp Leu Leu Tyr Gln Glu Phe Leu Pro Leu Leu Pro 
    770                 775                 780                 


Asn Leu Leu Gln Gly Leu Asn Met Leu Gln Ser Gly Leu His Lys Gln 
785                 790                 795                 800 


His Met Lys Asp Leu Phe Val Glu Leu Cys Leu Thr Val Pro Val Arg 
                805                 810                 815     


Leu Ser Ser Leu Leu Pro Tyr Leu Pro Met Leu Met Asp Pro Leu Val 
            820                 825                 830         


Ser Ala Leu Asn Gly Ser Gln Thr Leu Val Ser Gln Gly Leu Arg Thr 
        835                 840                 845             


Leu Glu Leu Cys Val Asp Asn Leu Gln Pro Asp Phe Leu Tyr Asp His 
    850                 855                 860                 


Ile Gln Pro Val Arg Ala Glu Leu Met Gln Ala Leu Trp Arg Thr Leu 
865                 870                 875                 880 


Arg Asn Pro Ala Asp Ser Ile Ser His Val Ala Tyr Arg Val Leu Gly 
                885                 890                 895     


Lys Phe Gly Gly Ser Asn Arg Lys Met Leu Lys Glu Ser Gln Lys Leu 
            900                 905                 910         


His Tyr Val Val Thr Glu Val Gln Gly Pro Ser Ile Thr Val Glu Phe 
        915                 920                 925             


Ser Asp Cys Lys Ala Ser Leu Gln Leu Pro Met Glu Lys Ala Ile Glu 
    930                 935                 940                 


Thr Ala Leu Asp Cys Leu Lys Ser Ala Asn Thr Glu Pro Tyr Tyr Arg 
945                 950                 955                 960 


Arg Gln Ala Trp Glu Val Ile Lys Cys Phe Leu Val Ala Met Met Ser 
                965                 970                 975     


Leu Glu Asp Asn Lys His Ala Leu Tyr Gln Leu Leu Ala His Pro Asn 
            980                 985                 990         


Phe Thr Glu Lys Thr Ile Pro Asn  Val Ile Ile Ser His  Arg Tyr Lys 
        995                 1000                 1005             


Ala Gln  Asp Thr Pro Ala Arg  Lys Thr Phe Glu Gln  Ala Leu Thr 
    1010                 1015                 1020             


Gly Ala  Phe Met Ser Ala Val  Ile Lys Asp Leu Arg  Pro Ser Ala 
    1025                 1030                 1035             


Leu Pro  Phe Val Ala Ser Leu  Ile Arg His Tyr Thr  Met Val Ala 
    1040                 1045                 1050             


Val Ala  Gln Gln Cys Gly Pro  Phe Leu Leu Pro Cys  Tyr Gln Val 
    1055                 1060                 1065             


Gly Ser  Gln Pro Ser Thr Ala  Met Phe His Ser Glu  Glu Asn Gly 
    1070                 1075                 1080             


Ser Lys  Gly Met Asp Pro Leu  Val Leu Ile Asp Ala  Ile Ala Ile 
    1085                 1090                 1095             


Cys Met  Ala Tyr Glu Glu Lys  Glu Leu Cys Lys Ile  Gly Glu Val 
    1100                 1105                 1110             


Ala Leu  Ala Val Ile Phe Asp  Val Ala Ser Ile Ile  Leu Gly Ser 
    1115                 1120                 1125             


Lys Glu  Arg Ala Cys Gln Leu  Pro Leu Phe Ser Tyr  Ile Val Glu 
    1130                 1135                 1140             


Arg Leu  Cys Ala Cys Cys Tyr  Glu Gln Ala Trp Tyr  Ala Lys Leu 
    1145                 1150                 1155             


Gly Gly  Val Val Ser Ile Lys  Phe Leu Met Glu Arg  Leu Pro Leu 
    1160                 1165                 1170             


Thr Trp  Val Leu Gln Asn Gln  Gln Thr Phe Leu Lys  Ala Leu Leu 
    1175                 1180                 1185             


Phe Val  Met Met Asp Leu Thr  Gly Glu Val Ser Asn  Gly Ala Val 
    1190                 1195                 1200             


Ala Met  Ala Lys Thr Thr Leu  Glu Gln Leu Leu Met  Arg Cys Ala 
    1205                 1210                 1215             


Thr Pro  Leu Lys Asp Glu Glu  Arg Ala Glu Glu Ile  Val Ala Ala 
    1220                 1225                 1230             


Gln Glu  Lys Ser Phe His His  Val Thr His Asp Leu  Val Arg Glu 
    1235                 1240                 1245             


Val Thr  Ser Pro Asn Ser Thr  Val Arg Lys Gln Ala  Met His Ser 
    1250                 1255                 1260             


Leu Gln  Val Leu Ala Gln Val  Thr Gly Lys Ser Val  Thr Val Ile 
    1265                 1270                 1275             


Met Glu  Pro His Lys Glu Val  Leu Gln Asp Met Val  Pro Pro Lys 
    1280                 1285                 1290             


Lys His  Leu Leu Arg His Gln  Pro Ala Asn Ala Gln  Ile Gly Leu 
    1295                 1300                 1305             


Met Glu  Gly Asn Thr Phe Cys  Thr Thr Leu Gln Pro  Arg Leu Phe 
    1310                 1315                 1320             


Thr Met  Asp Leu Asn Val Val  Glu His Lys Val Phe  Tyr Thr Glu 
    1325                 1330                 1335             


Leu Leu  Asn Leu Cys Glu Ala  Glu Asp Ser Ala Leu  Thr Lys Leu 
    1340                 1345                 1350             


Pro Cys  Tyr Lys Ser Leu Pro  Ser Leu Val Pro Leu  Arg Ile Ala 
    1355                 1360                 1365             


Ala Leu  Asn Ala Leu Ala Ala  Cys Asn Tyr Leu Pro  Gln Ser Arg 
    1370                 1375                 1380             


Glu Lys  Ile Ile Ala Ala Leu  Phe Lys Ala Leu Asn  Ser Thr Asn 
    1385                 1390                 1395             


Ser Glu  Leu Gln Glu Ala Gly  Glu Ala Cys Met Arg  Lys Phe Leu 
    1400                 1405                 1410             


Glu Gly  Ala Thr Ile Glu Val  Asp Gln Ile His Thr  His Met Arg 
    1415                 1420                 1425             


Pro Leu  Leu Met Met Leu Gly  Asp Tyr Arg Ser Leu  Thr Leu Asn 
    1430                 1435                 1440             


Val Val  Asn Arg Leu Thr Ser  Val Thr Arg Leu Phe  Pro Asn Ser 
    1445                 1450                 1455             


Phe Asn  Asp Lys Phe Cys Asp  Gln Met Met Gln His  Leu Arg Lys 
    1460                 1465                 1470             


Trp Met  Glu Val Val Val Ile  Thr His Lys Gly Gly  Gln Arg Ser 
    1475                 1480                 1485             


Asp Gly  Asn Glu Ser Ile Ser  Glu Cys Gly Arg Cys  Pro Leu Ser 
    1490                 1495                 1500             


Pro Phe  Cys Gln Phe Glu Glu  Met Lys Ile Cys Ser  Ala Ile Ile 
    1505                 1510                 1515             


Asn Leu  Phe His Leu Ile Pro  Ala Ala Pro Gln Thr  Leu Val Lys 
    1520                 1525                 1530             


Pro Leu  Leu Glu Val Val Met  Lys Thr Glu Arg Ala  Met Leu Ile 
    1535                 1540                 1545             


Glu Ala  Gly Ser Pro Phe Arg  Glu Pro Leu Ile Lys  Phe Leu Thr 
    1550                 1555                 1560             


Arg His  Pro Ser Gln Thr Val  Glu Leu Phe Met Met  Glu Ala Thr 
    1565                 1570                 1575             


Leu Asn  Asp Pro Gln Trp Ser  Arg Met Phe Met Ser  Phe Leu Lys 
    1580                 1585                 1590             


His Lys  Asp Ala Arg Pro Leu  Arg Asp Val Leu Ala  Ala Asn Pro 
    1595                 1600                 1605             


Asn Arg  Phe Ile Thr Leu Leu  Leu Pro Gly Gly Ala  Gln Thr Ala 
    1610                 1615                 1620             


Val Arg  Pro Gly Ser Pro Ser  Thr Ser Thr Met Arg  Leu Asp Leu 
    1625                 1630                 1635             


Gln Phe  Gln Ala Ile Lys Ile  Ile Ser Ile Ile Val  Lys Asn Asp 
    1640                 1645                 1650             


Asp Ser  Trp Leu Ala Ser Gln  His Ser Leu Val Ser  Gln Leu Arg 
    1655                 1660                 1665             


Arg Val  Trp Val Ser Glu Asn  Phe Gln Glu Arg His  Arg Lys Glu 
    1670                 1675                 1680             


Asn Met  Ala Ala Thr Asn Trp  Lys Glu Pro Lys Leu  Leu Ala Tyr 
    1685                 1690                 1695             


Cys Leu  Leu Asn Tyr Cys Lys  Arg Asn Tyr Gly Asp  Ile Glu Leu 
    1700                 1705                 1710             


Leu Phe  Gln Leu Leu Arg Ala  Phe Thr Gly Arg Phe  Leu Cys Asn 
    1715                 1720                 1725             


Met Thr  Phe Leu Lys Glu Tyr  Met Glu Glu Glu Ile  Pro Lys Asn 
    1730                 1735                 1740             


Tyr Ser  Ile Ala Gln Lys Arg  Ala Leu Phe Phe Arg  Phe Val Asp 
    1745                 1750                 1755             


Phe Asn  Asp Pro Asn Phe Gly  Asp Glu Leu Lys Ala  Lys Val Leu 
    1760                 1765                 1770             


Gln His  Ile Leu Asn Pro Ala  Phe Leu Tyr Ser Phe  Glu Lys Gly 
    1775                 1780                 1785             


Glu Gly  Glu Gln Leu Leu Gly  Pro Pro Asn Pro Glu  Gly Asp Asn 
    1790                 1795                 1800             


Pro Glu  Ser Ile Thr Ser Val  Phe Ile Thr Lys Val  Leu Asp Pro 
    1805                 1810                 1815             


Glu Lys  Gln Ala Asp Met Leu  Asp Ser Leu Arg Ile  Tyr Leu Leu 
    1820                 1825                 1830             


Gln Tyr  Ala Thr Leu Leu Val  Glu His Ala Pro His  His Ile His 
    1835                 1840                 1845             


Asp Asn  Asn Lys Asn Arg Asn  Ser Lys Leu Arg Arg  Leu Met Thr 
    1850                 1855                 1860             


Phe Ala  Trp Pro Cys Leu Leu  Ser Lys Ala Cys Val  Asp Pro Ala 
    1865                 1870                 1875             


Cys Lys  Tyr Ser Gly His Leu  Leu Leu Ala His Ile  Ile Ala Lys 
    1880                 1885                 1890             


Phe Ala  Ile His Lys Lys Ile  Val Leu Gln Val Phe  His Ser Leu 
    1895                 1900                 1905             


Leu Lys  Ala His Ala Met Glu  Ala Arg Ala Ile Val  Arg Gln Ala 
    1910                 1915                 1920             


Met Ala  Ile Leu Thr Pro Ala  Val Pro Ala Arg Met  Glu Asp Gly 
    1925                 1930                 1935             


His Gln  Met Leu Thr His Trp  Thr Arg Lys Ile Ile  Val Glu Glu 
    1940                 1945                 1950             


Gly His  Thr Val Pro Gln Leu  Val His Ile Leu His  Leu Ile Val 
    1955                 1960                 1965             


Gln His  Phe Lys Val Tyr Tyr  Pro Val Arg His His  Leu Val Gln 
    1970                 1975                 1980             


His Met  Val Ser Ala Met Gln  Arg Leu Gly Phe Thr  Pro Ser Val 
    1985                 1990                 1995             


Thr Ile  Glu Gln Arg Arg Leu  Ala Val Asp Leu Ser  Glu Val Val 
    2000                 2005                 2010             


Ile Lys  Trp Glu Leu Gln Arg  Ile Lys Asp Gln Gln  Pro Asp Ser 
    2015                 2020                 2025             


Asp Met  Asp Pro Asn Ser Ser  Gly Glu Gly Val Asn  Ser Val Ser 
    2030                 2035                 2040             


Ser Ser  Ile Lys Arg Gly Leu  Ser Val Asp Ser Ala  Gln Glu Val 
    2045                 2050                 2055             


Lys Arg  Phe Arg Thr Ala Thr  Gly Ala Ile Ser Ala  Val Phe Gly 
    2060                 2065                 2070             


Arg Ser  Gln Ser Leu Pro Gly  Ala Asp Ser Leu Leu  Ala Lys Pro 
    2075                 2080                 2085             


Ile Asp  Lys Gln His Thr Asp  Thr Val Val Asn Phe  Leu Ile Arg 
    2090                 2095                 2100             


Val Ala  Cys Gln Val Asn Asp  Asn Thr Asn Thr Ala  Gly Ser Pro 
    2105                 2110                 2115             


Gly Glu  Val Leu Ser Arg Arg  Cys Val Asn Leu Leu  Lys Thr Ala 
    2120                 2125                 2130             


Leu Arg  Pro Asp Met Trp Pro  Lys Ser Glu Leu Lys  Leu Gln Trp 
    2135                 2140                 2145             


Phe Asp  Lys Leu Leu Met Thr  Val Glu Gln Pro Asn  Gln Val Asn 
    2150                 2155                 2160             


Tyr Gly  Asn Ile Cys Thr Gly  Leu Glu Val Leu Ser  Phe Leu Leu 
    2165                 2170                 2175             


Thr Val  Leu Gln Ser Pro Ala  Ile Leu Ser Ser Phe  Lys Pro Leu 
    2180                 2185                 2190             


Gln Arg  Gly Ile Ala Ala Cys  Met Thr Cys Gly Asn  Thr Lys Val 
    2195                 2200                 2205             


Leu Arg  Ala Val His Ser Leu  Leu Ser Arg Leu Met  Ser Ile Phe 
    2210                 2215                 2220             


Pro Thr  Glu Pro Ser Thr Ser  Ser Val Ala Ser Lys  Tyr Glu Glu 
    2225                 2230                 2235             


Leu Glu  Cys Leu Tyr Ala Ala  Val Gly Lys Val Ile  Tyr Glu Gly 
    2240                 2245                 2250             


Leu Thr  Asn Tyr Glu Lys Ala  Thr Asn Ala Asn Pro  Ser Gln Leu 
    2255                 2260                 2265             


Phe Gly  Thr Leu Met Ile Leu  Lys Ser Ala Cys Ser  Asn Asn Pro 
    2270                 2275                 2280             


Ser Tyr  Ile Asp Arg Leu Ile  Ser Val Phe Met Arg  Ser Leu Gln 
    2285                 2290                 2295             


Lys Met  Val Arg Glu His Leu  Asn Pro Gln Ala Ala  Ser Gly Ser 
    2300                 2305                 2310             


Thr Glu  Ala Thr Ser Gly Thr  Ser Glu Leu Val Met  Leu Ser Leu 
    2315                 2320                 2325             


Glu Leu  Val Lys Thr Arg Leu  Ala Val Met Ser Met  Glu Met Arg 
    2330                 2335                 2340             


Lys Asn  Phe Ile Gln Ala Ile  Leu Thr Ser Leu Ile  Glu Lys Ser 
    2345                 2350                 2355             


Pro Asp  Ala Lys Ile Leu Arg  Ala Val Val Lys Ile  Val Glu Glu 
    2360                 2365                 2370             


Trp Val  Lys Asn Asn Ser Pro  Met Ala Ala Asn Gln  Thr Pro Thr 
    2375                 2380                 2385             


Leu Arg  Glu Lys Ser Ile Leu  Leu Val Lys Met Met  Thr Tyr Ile 
    2390                 2395                 2400             


Glu Lys  Arg Phe Pro Glu Asp  Leu Glu Leu Asn Ala  Gln Phe Leu 
    2405                 2410                 2415             


Asp Leu  Val Asn Tyr Val Tyr  Arg Asp Glu Thr Leu  Ser Gly Ser 
    2420                 2425                 2430             


Glu Leu  Thr Ala Lys Leu Glu  Pro Ala Phe Leu Ser  Gly Leu Arg 
    2435                 2440                 2445             


Cys Ala  Gln Pro Leu Ile Arg  Ala Lys Phe Phe Glu  Val Phe Asp 
    2450                 2455                 2460             


Asn Ser  Met Lys Arg Arg Val  Tyr Glu Arg Leu Leu  Tyr Val Thr 
    2465                 2470                 2475             


Cys Ser  Gln Asn Trp Glu Ala  Met Gly Asn His Phe  Trp Ile Lys 
    2480                 2485                 2490             


Gln Cys  Ile Glu Leu Leu Leu  Ala Val Cys Glu Lys  Ser Thr Pro 
    2495                 2500                 2505             


Ile Gly  Thr Ser Cys Gln Gly  Ala Met Leu Pro Ser  Ile Thr Asn 
    2510                 2515                 2520             


Val Ile  Asn Leu Ala Asp Ser  His Asp Arg Ala Ala  Phe Ala Met 
    2525                 2530                 2535             


Val Thr  His Val Lys Gln Glu  Pro Arg Glu Arg Glu  Asn Ser Glu 
    2540                 2545                 2550             


Ser Lys  Glu Glu Asp Val Glu  Ile Asp Ile Glu Leu  Ala Pro Gly 
    2555                 2560                 2565             


Asp Gln  Thr Ser Thr Pro Lys  Thr Lys Glu Leu Ser  Glu Lys Asp 
    2570                 2575                 2580             


Ile Gly  Asn Gln Leu His Met  Leu Thr Asn Arg His  Asp Lys Phe 
    2585                 2590                 2595             


Leu Asp  Thr Leu Arg Glu Val  Lys Thr Gly Ala Leu  Leu Ser Ala 
    2600                 2605                 2610             


Phe Val  Gln Leu Cys His Ile  Ser Thr Thr Leu Ala  Glu Lys Thr 
    2615                 2620                 2625             


Trp Val  Gln Leu Phe Pro Arg  Leu Trp Lys Ile Leu  Ser Asp Arg 
    2630                 2635                 2640             


Gln Gln  His Ala Leu Ala Gly  Glu Ile Ser Pro Phe  Leu Cys Ser 
    2645                 2650                 2655             


Gly Ser  His Gln Val Gln Arg  Asp Cys Gln Pro Ser  Ala Leu Asn 
    2660                 2665                 2670             


Cys Phe  Val Glu Ala Met Ser  Gln Cys Val Pro Pro  Ile Pro Ile 
    2675                 2680                 2685             


Arg Pro  Cys Val Leu Lys Tyr  Leu Gly Lys Thr His  Asn Leu Trp 
    2690                 2695                 2700             


Phe Arg  Ser Thr Leu Met Leu  Glu His Gln Ala Phe  Glu Lys Gly 
    2705                 2710                 2715             


Leu Ser  Leu Gln Ile Lys Pro  Lys Gln Thr Thr Glu  Phe Tyr Glu 
    2720                 2725                 2730             


Gln Glu  Ser Ile Thr Pro Pro  Gln Gln Glu Ile Leu  Asp Ser Leu 
    2735                 2740                 2745             


Ala Glu  Leu Tyr Ser Leu Leu  Gln Glu Glu Asp Met  Trp Ala Gly 
    2750                 2755                 2760             


Leu Trp  Gln Lys Arg Cys Lys  Tyr Ser Glu Thr Ala  Thr Ala Ile 
    2765                 2770                 2775             


Ala Tyr  Glu Gln His Gly Phe  Phe Glu Gln Ala Gln  Glu Ser Tyr 
    2780                 2785                 2790             


Glu Lys  Ala Met Asp Lys Ala  Lys Lys Glu His Glu  Arg Ser Asn 
    2795                 2800                 2805             


Ala Ser  Pro Ala Ile Phe Pro  Glu Tyr Gln Leu Trp  Glu Asp His 
    2810                 2815                 2820             


Trp Ile  Arg Cys Ser Lys Glu  Leu Asn Gln Trp Glu  Ala Leu Thr 
    2825                 2830                 2835             


Glu Tyr  Gly Gln Ser Lys Gly  His Ile Asn Pro Tyr  Leu Val Leu 
    2840                 2845                 2850             


Glu Cys  Ala Trp Arg Val Ser  Asn Trp Thr Ala Met  Lys Glu Ala 
    2855                 2860                 2865             


Leu Val  Gln Val Glu Val Ser  Cys Pro Lys Glu Met  Ala Trp Lys 
    2870                 2875                 2880             


Val Asn  Met Tyr Arg Gly Tyr  Leu Ala Ile Cys His  Pro Glu Glu 
    2885                 2890                 2895             


Gln Gln  Leu Ser Phe Ile Glu  Arg Leu Val Glu Met  Ala Ser Ser 
    2900                 2905                 2910             


Leu Ala  Ile Arg Glu Trp Arg  Arg Leu Pro His Val  Val Ser His 
    2915                 2920                 2925             


Val His  Thr Pro Leu Leu Gln  Ala Ala Gln Gln Ile  Ile Glu Leu 
    2930                 2935                 2940             


Gln Glu  Ala Ala Gln Ile Asn  Ala Gly Leu Gln Pro  Thr Asn Leu 
    2945                 2950                 2955             


Gly Arg  Asn Asn Ser Leu His  Asp Met Lys Thr Val  Val Lys Thr 
    2960                 2965                 2970             


Trp Arg  Asn Arg Leu Pro Ile  Val Ser Asp Asp Leu  Ser His Trp 
    2975                 2980                 2985             


Ser Ser  Ile Phe Met Trp Arg  Gln His His Tyr Gln  Gly Lys Pro 
    2990                 2995                 3000             


Thr Trp  Ser Gly Met His Ser  Ser Ser Ile Val Thr  Ala Tyr Glu 
    3005                 3010                 3015             


Asn Ser  Ser Gln His Asp Pro  Ser Ser Asn Asn Ala  Met Leu Gly 
    3020                 3025                 3030             


Val His  Ala Ser Ala Ser Ala  Ile Ile Gln Tyr Gly  Lys Ile Ala 
    3035                 3040                 3045             


Arg Lys  Gln Gly Leu Val Asn  Val Ala Leu Asp Ile  Leu Ser Arg 
    3050                 3055                 3060             


Ile His  Thr Ile Pro Thr Val  Pro Ile Val Asp Cys  Phe Gln Lys 
    3065                 3070                 3075             


Ile Arg  Gln Gln Val Lys Cys  Tyr Leu Gln Leu Ala  Gly Val Met 
    3080                 3085                 3090             


Gly Lys  Asn Glu Cys Met Gln  Gly Leu Glu Val Ile  Glu Ser Thr 
    3095                 3100                 3105             


Asn Leu  Lys Tyr Phe Thr Lys  Glu Met Thr Ala Glu  Phe Tyr Ala 
    3110                 3115                 3120             


Leu Lys  Gly Met Phe Leu Ala  Gln Ile Asn Lys Ser  Glu Glu Ala 
    3125                 3130                 3135             


Asn Lys  Ala Phe Ser Ala Ala  Val Gln Met His Asp  Val Leu Val 
    3140                 3145                 3150             


Lys Ala  Trp Ala Met Trp Gly  Asp Tyr Leu Glu Asn  Ile Phe Val 
    3155                 3160                 3165             


Lys Glu  Arg Gln Leu His Leu  Gly Val Ser Ala Ile  Thr Cys Tyr 
    3170                 3175                 3180             


Leu His  Ala Cys Arg His Gln  Asn Glu Ser Lys Ser  Arg Lys Tyr 
    3185                 3190                 3195             


Leu Ala  Lys Val Leu Trp Leu  Leu Ser Phe Asp Asp  Asp Lys Asn 
    3200                 3205                 3210             


Thr Leu  Ala Asp Ala Val Asp  Lys Tyr Cys Ile Gly  Val Pro Pro 
    3215                 3220                 3225             


Ile Gln  Trp Leu Ala Trp Ile  Pro Gln Leu Leu Thr  Cys Leu Val 
    3230                 3235                 3240             


Gly Ser  Glu Gly Lys Leu Leu  Leu Asn Leu Ile Ser  Gln Val Gly 
    3245                 3250                 3255             


Arg Val  Tyr Pro Gln Ala Val  Tyr Phe Pro Ile Arg  Thr Leu Tyr 
    3260                 3265                 3270             


Leu Thr  Leu Lys Ile Glu Gln  Arg Glu Arg Tyr Lys  Ser Asp Pro 
    3275                 3280                 3285             


Gly Pro  Ile Arg Ala Thr Ala  Pro Met Trp Arg Cys  Ser Arg Ile 
    3290                 3295                 3300             


Met His  Met Gln Arg Glu Leu  His Pro Thr Leu Leu  Ser Ser Leu 
    3305                 3310                 3315             


Glu Gly  Ile Val Asp Gln Met  Val Trp Phe Arg Glu  Asn Trp His 
    3320                 3325                 3330             


Glu Glu  Val Leu Arg Gln Leu  Gln Gln Gly Leu Ala  Lys Cys Tyr 
    3335                 3340                 3345             


Ser Val  Ala Phe Glu Lys Ser  Gly Ala Val Ser Asp  Ala Lys Ile 
    3350                 3355                 3360             


Thr Pro  His Thr Leu Asn Phe  Val Lys Lys Leu Val  Ser Thr Phe 
    3365                 3370                 3375             


Gly Val  Gly Leu Glu Asn Val  Ser Asn Val Ser Thr  Met Phe Ser 
    3380                 3385                 3390             


Ser Ala  Ala Ser Glu Ser Leu  Ala Arg Arg Ala Gln  Ala Thr Ala 
    3395                 3400                 3405             


Gln Asp  Pro Val Phe Gln Lys  Leu Lys Gly Gln Phe  Thr Thr Asp 
    3410                 3415                 3420             


Phe Asp  Phe Ser Val Pro Gly  Ser Met Lys Leu His  Asn Leu Ile 
    3425                 3430                 3435             


Ser Lys  Leu Lys Lys Trp Ile  Lys Ile Leu Glu Ala  Lys Thr Lys 
    3440                 3445                 3450             


Gln Leu  Pro Lys Phe Phe Leu  Ile Glu Glu Lys Cys  Arg Phe Leu 
    3455                 3460                 3465             


Ser Asn  Phe Ser Ala Gln Thr  Ala Glu Val Glu Ile  Pro Gly Glu 
    3470                 3475                 3480             


Phe Leu  Met Pro Lys Pro Thr  His Tyr Tyr Ile Lys  Ile Ala Arg 
    3485                 3490                 3495             


Phe Met  Pro Arg Val Glu Ile  Val Gln Lys His Asn  Thr Ala Ala 
    3500                 3505                 3510             


Arg Arg  Leu Tyr Ile Arg Gly  His Asn Gly Lys Ile  Tyr Pro Tyr 
    3515                 3520                 3525             


Leu Val  Met Asn Asp Ala Cys  Leu Thr Glu Ser Arg  Arg Glu Glu 
    3530                 3535                 3540             


Arg Val  Leu Gln Leu Leu Arg  Leu Leu Asn Pro Cys  Leu Glu Lys 
    3545                 3550                 3555             


Arg Lys  Glu Thr Thr Lys Arg  His Leu Phe Phe Thr  Val Pro Arg 
    3560                 3565                 3570             


Val Val  Ala Val Ser Pro Gln  Met Arg Leu Val Glu  Asp Asn Pro 
    3575                 3580                 3585             


Ser Ser  Leu Ser Leu Val Glu  Ile Tyr Lys Gln Arg  Cys Ala Lys 
    3590                 3595                 3600             


Lys Gly  Ile Glu His Asp Asn  Pro Ile Ser Arg Tyr  Tyr Asp Arg 
    3605                 3610                 3615             


Leu Ala  Thr Val Gln Ala Arg  Gly Thr Gln Ala Ser  His Gln Val 
    3620                 3625                 3630             


Leu Arg  Asp Ile Leu Lys Glu  Val Gln Ser Asn Met  Val Pro Arg 
    3635                 3640                 3645             


Ser Met  Leu Lys Glu Trp Ala  Leu His Thr Phe Pro  Asn Ala Thr 
    3650                 3655                 3660             


Asp Tyr  Trp Thr Phe Arg Lys  Met Phe Thr Ile Gln  Leu Ala Leu 
    3665                 3670                 3675             


Ile Gly  Phe Ala Glu Phe Val  Leu His Leu Asn Arg  Leu Asn Pro 
    3680                 3685                 3690             


Glu Met  Leu Gln Ile Ala Gln  Asp Thr Gly Lys Leu  Asn Val Ala 
    3695                 3700                 3705             


Tyr Phe  Arg Phe Asp Ile Asn  Asp Ala Thr Gly Asp  Leu Asp Ala 
    3710                 3715                 3720             


Asn Arg  Pro Val Pro Phe Arg  Leu Thr Pro Asn Ile  Ser Glu Phe 
    3725                 3730                 3735             


Leu Thr  Thr Ile Gly Val Ser  Gly Pro Leu Thr Ala  Ser Met Ile 
    3740                 3745                 3750             


Ala Val  Ala Arg Cys Phe Ala  Gln Pro Asn Phe Lys  Val Asp Gly 
    3755                 3760                 3765             


Ile Leu  Lys Thr Val Leu Arg  Asp Glu Ile Ile Ala  Trp His Lys 
    3770                 3775                 3780             


Lys Thr  Gln Glu Asp Thr Ser  Ser Pro Leu Ser Ala  Ala Gly Gln 
    3785                 3790                 3795             


Pro Glu  Asn Met Asp Ser Gln  Gln Leu Val Ser Leu  Val Gln Lys 
    3800                 3805                 3810             


Ala Val  Thr Ala Ile Met Thr  Arg Leu His Asn Leu  Ala Gln Phe 
    3815                 3820                 3825             


Glu Gly  Gly Glu Ser Lys Val  Asn Thr Leu Val Ala  Ala Ala Asn 
    3830                 3835                 3840             


Ser Leu  Asp Asn Leu Cys Arg  Met Asp Pro Ala Trp  His Pro Trp 
    3845                 3850                 3855             


Leu 
    


<210>  11
<211>  1239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Ala Asn Asp Ser Pro Ala Lys Ser Leu Val Asp Ile Asp Leu Ser 
1               5                   10                  15      


Ser Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Glu Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Leu Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly 
                85                  90                  95      


His Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Ile Thr Asp Leu Val Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Asp 
        115                 120                 125             


Trp Ile Ala Tyr Ile Ser Arg Glu Ile Leu Arg Gly Leu Ala His Leu 
    130                 135                 140                 


His Ile His His Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Tyr Arg Ser Asp Leu Trp Ser Cys Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Pro Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Phe Ser Phe Ile Glu Gly Cys Leu Val Lys 
            260                 265                 270         


Asn Tyr Met Gln Arg Pro Ser Thr Glu Gln Leu Leu Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Arg Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Val Pro Glu Gln 
                325                 330                 335     


Glu Gly Glu Pro Ser Ser Ile Val Asn Val Pro Gly Glu Ser Thr Leu 
            340                 345                 350         


Arg Arg Asp Phe Leu Arg Leu Gln Gln Glu Asn Lys Glu Arg Ser Glu 
        355                 360                 365             


Ala Leu Arg Arg Gln Gln Leu Leu Gln Glu Gln Gln Leu Arg Glu Gln 
    370                 375                 380                 


Glu Glu Tyr Lys Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu 
385                 390                 395                 400 


Gln Gln Lys Glu Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu 
                405                 410                 415     


Arg Glu Ala Arg Arg Gln Gln Glu Arg Glu Gln Arg Arg Arg Glu Gln 
            420                 425                 430         


Glu Glu Lys Arg Arg Leu Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu 
        435                 440                 445             


Glu Glu Arg Arg Arg Ala Glu Glu Glu Lys Arg Arg Val Glu Arg Glu 
    450                 455                 460                 


Gln Glu Tyr Ile Arg Arg Gln Leu Glu Glu Glu Gln Arg His Leu Glu 
465                 470                 475                 480 


Val Leu Gln Gln Gln Leu Leu Gln Glu Gln Ala Met Leu Leu Glu Cys 
                485                 490                 495     


Arg Trp Arg Glu Met Glu Glu His Arg Gln Ala Glu Arg Leu Gln Arg 
            500                 505                 510         


Gln Leu Gln Gln Glu Gln Ala Tyr Leu Leu Ser Leu Gln His Asp His 
        515                 520                 525             


Arg Arg Pro His Pro Gln His Ser Gln Gln Pro Pro Pro Pro Gln Gln 
    530                 535                 540                 


Glu Arg Ser Lys Pro Ser Phe His Ala Pro Glu Pro Lys Ala His Tyr 
545                 550                 555                 560 


Glu Pro Ala Asp Arg Ala Arg Glu Val Glu Asp Arg Phe Arg Lys Thr 
                565                 570                 575     


Asn His Ser Ser Pro Glu Ala Gln Ser Lys Gln Thr Gly Arg Val Leu 
            580                 585                 590         


Glu Pro Pro Val Pro Ser Arg Ser Glu Ser Phe Ser Asn Gly Asn Ser 
        595                 600                 605             


Glu Ser Val His Pro Ala Leu Gln Arg Pro Ala Glu Pro Gln Val Pro 
    610                 615                 620                 


Val Arg Thr Thr Ser Arg Ser Pro Val Leu Ser Arg Arg Asp Ser Pro 
625                 630                 635                 640 


Leu Gln Gly Ser Gly Gln Gln Asn Ser Gln Ala Gly Gln Arg Asn Ser 
                645                 650                 655     


Thr Ser Ile Glu Pro Arg Leu Leu Trp Glu Arg Val Glu Lys Leu Val 
            660                 665                 670         


Pro Arg Pro Gly Ser Gly Ser Ser Ser Gly Ser Ser Asn Ser Gly Ser 
        675                 680                 685             


Gln Pro Gly Ser His Pro Gly Ser Gln Ser Gly Ser Gly Glu Arg Phe 
    690                 695                 700                 


Arg Val Arg Ser Ser Ser Lys Ser Glu Gly Ser Pro Ser Gln Arg Leu 
705                 710                 715                 720 


Glu Asn Ala Val Lys Lys Pro Glu Asp Lys Lys Glu Val Phe Arg Pro 
                725                 730                 735     


Leu Lys Pro Ala Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Ala Val 
            740                 745                 750         


Glu Asp Val Arg Pro Pro His Lys Val Thr Asp Tyr Ser Ser Ser Ser 
        755                 760                 765             


Glu Glu Ser Gly Thr Thr Asp Glu Glu Asp Asp Asp Val Glu Gln Glu 
    770                 775                 780                 


Gly Ala Asp Glu Ser Thr Ser Gly Pro Glu Asp Thr Arg Ala Ala Ser 
785                 790                 795                 800 


Ser Leu Asn Leu Ser Asn Gly Glu Thr Glu Ser Val Lys Thr Met Ile 
                805                 810                 815     


Val His Asp Asp Val Glu Ser Glu Pro Ala Met Thr Pro Ser Lys Glu 
            820                 825                 830         


Gly Thr Leu Ile Val Arg Gln Thr Gln Ser Ala Ser Ser Thr Leu Gln 
        835                 840                 845             


Lys His Lys Ser Ser Ser Ser Phe Thr Pro Phe Ile Asp Pro Arg Leu 
    850                 855                 860                 


Leu Gln Ile Ser Pro Ser Ser Gly Thr Thr Val Thr Ser Val Val Gly 
865                 870                 875                 880 


Phe Ser Cys Asp Gly Met Arg Pro Glu Ala Ile Arg Gln Asp Pro Thr 
                885                 890                 895     


Arg Lys Gly Ser Val Val Asn Val Asn Pro Thr Asn Thr Arg Pro Gln 
            900                 905                 910         


Ser Asp Thr Pro Glu Ile Arg Lys Tyr Lys Lys Arg Phe Asn Ser Glu 
        915                 920                 925             


Ile Leu Cys Ala Ala Leu Trp Gly Val Asn Leu Leu Val Gly Thr Glu 
    930                 935                 940                 


Ser Gly Leu Met Leu Leu Asp Arg Ser Gly Gln Gly Lys Val Tyr Pro 
945                 950                 955                 960 


Leu Ile Asn Arg Arg Arg Phe Gln Gln Met Asp Val Leu Glu Gly Leu 
                965                 970                 975     


Asn Val Leu Val Thr Ile Ser Gly Lys Lys Asp Lys Leu Arg Val Tyr 
            980                 985                 990         


Tyr Leu Ser Trp Leu Arg Asn Lys  Ile Leu His Asn Asp  Pro Glu Val 
        995                 1000                 1005             


Glu Lys  Lys Gln Gly Trp Thr  Thr Val Gly Asp Leu  Glu Gly Cys 
    1010                 1015                 1020             


Val His  Tyr Lys Val Val Lys  Tyr Glu Arg Ile Lys  Phe Leu Val 
    1025                 1030                 1035             


Ile Ala  Leu Lys Ser Ser Val  Glu Val Tyr Ala Trp  Ala Pro Lys 
    1040                 1045                 1050             


Pro Tyr  His Lys Phe Met Ala  Phe Lys Ser Phe Gly  Glu Leu Val 
    1055                 1060                 1065             


His Lys  Pro Leu Leu Val Asp  Leu Thr Val Glu Glu  Gly Gln Arg 
    1070                 1075                 1080             


Leu Lys  Val Ile Tyr Gly Ser  Cys Ala Gly Phe His  Ala Val Asp 
    1085                 1090                 1095             


Val Asp  Ser Gly Ser Val Tyr  Asp Ile Tyr Leu Pro  Thr His Ile 
    1100                 1105                 1110             


Gln Cys  Ser Ile Lys Pro His  Ala Ile Ile Ile Leu  Pro Asn Thr 
    1115                 1120                 1125             


Asp Gly  Met Glu Leu Leu Val  Cys Tyr Glu Asp Glu  Gly Val Tyr 
    1130                 1135                 1140             


Val Asn  Thr Tyr Gly Arg Ile  Thr Lys Asp Val Val  Leu Gln Trp 
    1145                 1150                 1155             


Gly Glu  Met Pro Thr Ser Val  Ala Tyr Ile Arg Ser  Asn Gln Thr 
    1160                 1165                 1170             


Met Gly  Trp Gly Glu Lys Ala  Ile Glu Ile Arg Ser  Val Glu Thr 
    1175                 1180                 1185             


Gly His  Leu Asp Gly Val Phe  Met His Lys Arg Ala  Gln Arg Leu 
    1190                 1195                 1200             


Lys Phe  Leu Cys Glu Arg Asn  Asp Lys Val Phe Phe  Ala Ser Val 
    1205                 1210                 1215             


Arg Ser  Gly Gly Ser Ser Gln  Val Tyr Phe Met Thr  Leu Gly Arg 
    1220                 1225                 1230             


Thr Ser  Leu Leu Ser Trp 
    1235                 


<210>  12
<211>  859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Ala Cys Leu His Glu Thr Arg Thr Pro Ser Pro Ser Phe Gly Gly 
1               5                   10                  15      


Phe Val Ser Thr Leu Ser Glu Ala Ser Met Arg Lys Leu Asp Pro Asp 
            20                  25                  30          


Thr Ser Asp Cys Thr Pro Glu Lys Asp Leu Thr Pro Thr His Val Leu 
        35                  40                  45              


Gln Leu His Glu Gln Asp Ala Gly Gly Pro Gly Gly Ala Ala Gly Ser 
    50                  55                  60                  


Pro Glu Ser Arg Ala Ser Arg Val Arg Ala Asp Glu Val Arg Leu Gln 
65                  70                  75                  80  


Cys Gln Ser Gly Ser Gly Phe Leu Glu Gly Leu Phe Gly Cys Leu Arg 
                85                  90                  95      


Pro Val Trp Thr Met Ile Gly Lys Ala Tyr Ser Thr Glu His Lys Gln 
            100                 105                 110         


Gln Gln Glu Asp Leu Trp Glu Val Pro Phe Glu Glu Ile Leu Asp Leu 
        115                 120                 125             


Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe Leu Gly Arg Phe 
    130                 135                 140                 


His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp Leu Lys Glu Thr 
145                 150                 155                 160 


Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn Ile Ile Thr Phe 
                165                 170                 175     


Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile Leu Met Glu Phe 
            180                 185                 190         


Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala Gly Arg Pro Val 
        195                 200                 205             


Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile Ala Gly Gly Met 
    210                 215                 220                 


Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp Leu Lys Ser Pro 
225                 230                 235                 240 


Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile Ser Asp Phe Gly 
                245                 250                 255     


Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met Ser Phe Ala Gly 
            260                 265                 270         


Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn Glu Pro Val Ser 
        275                 280                 285             


Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Leu Leu 
    290                 295                 300                 


Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser Ala Ile Ile Trp 
305                 310                 315                 320 


Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro Ser Ser Cys Pro 
                325                 330                 335     


Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn Ser Lys Pro Arg 
            340                 345                 350         


Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu Asp Ile Ala Ser 
        355                 360                 365             


Ala Asp Val Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln Ala 
    370                 375                 380                 


Glu Trp Arg Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser Glu 
385                 390                 395                 400 


Gly Thr Cys Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg Arg 
                405                 410                 415     


Glu Glu Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg Lys 
            420                 425                 430         


Leu Glu Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met Leu 
        435                 440                 445             


Gln Leu Glu Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala Leu 
    450                 455                 460                 


Glu Arg Arg Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly Leu 
465                 470                 475                 480 


Leu His Gly Asn Thr Met Glu Lys Leu Ile Lys Lys Arg Asn Val Pro 
                485                 490                 495     


Gln Lys Leu Ser Pro His Ser Lys Arg Pro Asp Ile Leu Lys Thr Glu 
            500                 505                 510         


Ser Leu Leu Pro Lys Leu Asp Ala Ala Leu Ser Gly Val Gly Leu Pro 
        515                 520                 525             


Gly Cys Pro Lys Gly Pro Pro Ser Pro Gly Arg Ser Arg Arg Gly Lys 
    530                 535                 540                 


Thr Arg His Arg Lys Ala Ser Ala Lys Gly Ser Cys Gly Asp Leu Pro 
545                 550                 555                 560 


Gly Leu Arg Thr Ala Val Pro Pro His Glu Pro Gly Gly Pro Gly Ser 
                565                 570                 575     


Pro Gly Gly Leu Gly Gly Gly Pro Ser Ala Trp Glu Ala Cys Pro Pro 
            580                 585                 590         


Ala Leu Arg Gly Leu His His Asp Leu Leu Leu Arg Lys Met Ser Ser 
        595                 600                 605             


Ser Ser Pro Asp Leu Leu Ser Ala Ala Leu Gly Ser Arg Gly Arg Gly 
    610                 615                 620                 


Ala Thr Gly Gly Ala Gly Asp Pro Gly Ser Pro Pro Pro Ala Arg Gly 
625                 630                 635                 640 


Asp Thr Pro Pro Ser Glu Gly Ser Ala Pro Gly Ser Thr Ser Pro Asp 
                645                 650                 655     


Ser Pro Gly Gly Ala Lys Gly Glu Pro Pro Pro Pro Val Gly Pro Gly 
            660                 665                 670         


Glu Gly Val Gly Leu Leu Gly Thr Gly Arg Glu Gly Thr Ser Gly Arg 
        675                 680                 685             


Gly Gly Ser Arg Ala Gly Ser Gln His Leu Thr Pro Ala Ala Leu Leu 
    690                 695                 700                 


Tyr Arg Ala Ala Val Thr Arg Ser Gln Lys Arg Gly Ile Ser Ser Glu 
705                 710                 715                 720 


Glu Glu Glu Gly Glu Val Asp Ser Glu Val Glu Leu Thr Ser Ser Gln 
                725                 730                 735     


Arg Trp Pro Gln Ser Leu Asn Met Arg Gln Ser Leu Ser Thr Phe Ser 
            740                 745                 750         


Ser Glu Asn Pro Ser Asp Gly Glu Glu Gly Thr Ala Ser Glu Pro Ser 
        755                 760                 765             


Pro Ser Gly Thr Pro Glu Val Gly Ser Thr Asn Thr Asp Glu Arg Pro 
    770                 775                 780                 


Asp Glu Arg Ser Asp Asp Met Cys Ser Gln Gly Ser Glu Ile Pro Leu 
785                 790                 795                 800 


Asp Pro Pro Pro Ser Glu Val Ile Pro Gly Pro Glu Pro Ser Ser Leu 
                805                 810                 815     


Pro Ile Pro His Gln Glu Leu Leu Arg Glu Arg Gly Pro Pro Asn Ser 
            820                 825                 830         


Glu Asp Ser Asp Cys Asp Ser Thr Glu Leu Asp Asn Ser Asn Ser Val 
        835                 840                 845             


Asp Ala Leu Arg Pro Pro Ala Ser Leu Pro Pro 
    850                 855                 


