                               SEQUENCE LISTING

<110> BIOLEGEND, INC.
 
<120> METHODS FOR DETECTING METEORIN-BETA ACTIVITY

<130> AD2098 PCT

<140> PCT/US2020/016780
<141> 2020-02-05

<150> US 62/803,047
<151> 2019-02-08

<160> 30    

<170> PatentIn version 3.5

<210> 1
<211> 311
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Gly Ala Ala Arg Ala Ala Trp Gly Arg Ala Gly Gln Pro Trp 
1               5                   10                  15      


Pro Arg Pro Pro Ala Pro Gly Pro Pro Pro Pro Pro Leu Pro Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Ala Gly Leu Leu Gly Gly Ala Gly Ala Gln Tyr Ser 
        35                  40                  45              


Ser Asp Arg Cys Ser Trp Lys Gly Ser Gly Leu Thr His Glu Ala His 
    50                  55                  60                  


Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ala Ala Gly Ala Val 
65                  70                  75                  80  


Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Leu Arg Pro Asn 
                85                  90                  95      


Thr Phe Ser Pro Ala Arg His Leu Thr Val Cys Ile Arg Ser Phe Thr 
            100                 105                 110         


Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu Arg 
        115                 120                 125             


Leu Leu Val Pro Asp Gly Asp Gly Arg Pro Gly Arg Val Gln Cys Phe 
    130                 135                 140                 


Gly Leu Glu Gln Gly Gly Leu Phe Val Glu Ala Thr Pro Gln Gln Asp 
145                 150                 155                 160 


Ile Gly Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Val Arg Arg His 
                165                 170                 175     


Arg Ala Ser Asp Leu His Glu Leu Ser Ala Pro Cys Arg Pro Cys Ser 
            180                 185                 190         


Asp Thr Glu Val Leu Leu Ala Val Cys Thr Ser Asp Phe Ala Val Arg 
        195                 200                 205             


Gly Ser Ile Gln Gln Val Thr His Glu Pro Glu Arg Gln Asp Ser Ala 
    210                 215                 220                 


Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys Ser Arg Val Phe 
225                 230                 235                 240 


Glu Pro Val Pro Glu Gly Asp Gly His Trp Gln Gly Arg Val Arg Thr 
                245                 250                 255     


Leu Leu Glu Cys Gly Val Arg Pro Gly His Gly Asp Phe Leu Phe Thr 
            260                 265                 270         


Gly His Met His Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg Phe 
        275                 280                 285             


Lys Asp Phe Gln Arg Met Tyr Arg Asp Ala Gln Glu Arg Gly Leu Asn 
    290                 295                 300                 


Pro Cys Glu Val Gly Thr Asp 
305                 310     


<210> 2
<211> 1690
<212> DNA
<213> Homo sapiens

<400> 2
agaggctcgg cggcggcggc gggcgcggag ctctgcgcgc ggctccagcg ggccgggatg       60

ggcgggcggc cgcgcggagg acgcgggggg cgcgcgacgt gaccacccgg actcgaagcc      120

cgccccgccc ccgcccggct cgccggctcc ggggtctgct ccgggggtcg cggacgcggg      180

gccgggcggc ggagccggcg ccagagcatg cggggcgcgg cgcgggcggc ctgggggcgc      240

gcggggcagc cgtggccgcg accccccgcc ccgggcccgc ccccgccgcc gctcccgctg      300

ctgctcctgc tcctggccgg gctgctgggc ggcgcgggcg cgcagtactc cagcgaccgg      360

tgcagctgga aggggagcgg gctgacgcac gaggcacaca ggaaggaggt ggagcaggtg      420

tatctgcgct gtgcggcggg tgccgtggag tggatgtacc caacaggtgc tctcatcgtt      480

aacctgcggc ccaacacctt ctcgcctgcc cggcacctga ccgtgtgcat caggtccttc      540

acggactcct cgggggccaa tatttatttg gaaaaaactg gagaactgag actgctggta      600

ccagacgggg acggcaggcc cggccgggtg cagtgttttg gcctggagca gggcggcctg      660

ttcgtggagg ccacgccgca gcaggatatc ggccggagga ccacaggctt ccagtacgag      720

ctggttagga ggcacagggc gtcggacctg cacgagctgt ctgcgccgtg ccgtccctgc      780

agtgacaccg aggtgctcct agccgtctgc accagcgact tcgccgttcg aggctccatc      840

cagcaagtta cccacgagcc tgagcggcag gactcagcca tccacctgcg cgtgagcaga      900

ctctatcggc agaaaagcag ggtcttcgag ccggtgcccg agggtgacgg ccactggcag      960

gggcgcgtca ggacgctgct ggagtgtggc gtgcggccgg ggcatggcga cttcctcttc     1020

actggccaca tgcacttcgg ggaggcgcgg ctcggctgtg ccccacgctt caaggacttc     1080

cagaggatgt acagggatgc ccaggagagg gggctgaacc cttgtgaggt tggcacggac     1140

tgactccgtg ggccgctgcc cttcctctcc tgatgagtca caggctgcgg tgggcgctgc     1200

ggtcctggtg gggccgtgcg gtgagggccg cgcgctggga gccgcatgcc ctgggcccag     1260

gcctgaccct ggtaccgaag ctgtggacgt tctcgccaca ctcaacccca tgagcttcca     1320

gccaaggatg ccctggccga ttggaaatgc tgtaaaatgc aaactaagtt attatatttt     1380

tttttggtaa aaaagaaatg tccataggaa acaaattccc gtgtcttaaa acgccttggt     1440

gtgccgtctg atactgttct ctaaagacgt taggagtcac ggcatctggc ctgcggttgg     1500

gtgaagcact ggccgttggg cacagtggat gtgtgaaaag gtgccattca gagttgttat     1560

tctcatgacg gaagttttgg agccaaataa tacgtttttt attttcattt tatttttaaa     1620

ggatgagctt tggtcctttt caggccgccg gttgtttccg ttcccgagaa taaagacgag     1680

gatccgacca                                                            1690


<210> 3
<211> 311
<212> PRT
<213> Mus musculus

<400> 3
Met Arg Gly Ala Val Trp Ala Ala Arg Arg Arg Ala Gly Gln Gln Trp 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Gly Pro Gly Pro Pro Pro Pro Pro Pro Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Leu Gly Gly Ala Ser Ala Gln Tyr Ser 
        35                  40                  45              


Ser Asp Leu Cys Ser Trp Lys Gly Ser Gly Leu Thr Arg Glu Ala Arg 
    50                  55                  60                  


Ser Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ser Ala Gly Ser Val 
65                  70                  75                  80  


Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Leu Arg Pro Asn 
                85                  90                  95      


Thr Phe Ser Pro Ala Gln Asn Leu Thr Val Cys Ile Lys Pro Phe Arg 
            100                 105                 110         


Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu Arg 
        115                 120                 125             


Leu Leu Val Arg Asp Ile Arg Gly Glu Pro Gly Gln Val Gln Cys Phe 
    130                 135                 140                 


Ser Leu Glu Gln Gly Gly Leu Phe Val Glu Ala Thr Pro Gln Gln Asp 
145                 150                 155                 160 


Ile Ser Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Met Ser Gly Gln 
                165                 170                 175     


Arg Gly Leu Asp Leu His Val Leu Ser Ala Pro Cys Arg Pro Cys Ser 
            180                 185                 190         


Asp Thr Glu Val Leu Leu Ala Ile Cys Thr Ser Asp Phe Val Val Arg 
        195                 200                 205             


Gly Phe Ile Glu Asp Val Thr His Val Pro Glu Gln Gln Val Ser Val 
    210                 215                 220                 


Ile Tyr Leu Arg Val Asn Arg Leu His Arg Gln Lys Ser Arg Val Phe 
225                 230                 235                 240 


Gln Pro Ala Pro Glu Asp Ser Gly His Trp Leu Gly His Val Thr Thr 
                245                 250                 255     


Leu Leu Gln Cys Gly Val Arg Pro Gly His Gly Glu Phe Leu Phe Thr 
            260                 265                 270         


Gly His Val His Phe Gly Glu Ala Gln Leu Gly Cys Ala Pro Arg Phe 
        275                 280                 285             


Ser Asp Phe Gln Arg Met Tyr Arg Lys Ala Glu Glu Met Gly Ile Asn 
    290                 295                 300                 


Pro Cys Glu Ile Asn Met Glu 
305                 310     


<210> 4
<211> 2468
<212> DNA
<213> Mus musculus

<400> 4
agaggttcta ggggcagccg gcgcgcttct ctagttgcag cttgggcggc tcctgtggtg       60

ggcggctagg ggcgagccgg gatgggctat agacgcgcga cgtgatcagt tcgcacgcgg      120

acccacgcct cccatcgctc tgcctcaaga gcctattctg tgggtgcagg cacgcaccgg      180

acgcagaccc ggccggagca tgcggggtgc ggtgtgggcg gcccggaggc gcgcggggca      240

gcagtggcct cggtccccgg gccctgggcc gggtccgccc ccgccgccac cgctgctgtt      300

gctgctacta ctgctgctgg gcggcgcgag cgctcagtac tccagcgacc tgtgcagctg      360

gaaggggagt gggctcaccc gagaggcacg cagcaaggag gtggagcagg tgtacctgcg      420

ctgctccgca ggctctgtgg agtggatgta cccaactggg gcgctcattg ttaacctacg      480

gcccaacacc ttctcacctg cccagaactt gactgtgtgc atcaagcctt tcagggactc      540

ctctggagcc aatatttatt tggaaaaaac tggagaacta agactgttgg tgcgggacat      600

cagaggtgag cctggccaag tgcagtgctt cagcctggag cagggaggct tatttgtgga      660

ggcgacaccc caacaggaca tcagcagaag gaccacaggc ttccagtatg agctgatgag      720

tgggcagagg ggactggacc tgcacgtgct gtctgccccc tgtcggcctt gcagtgacac      780

tgaggtcctc cttgccatct gtaccagtga ctttgttgtc cgaggcttca ttgaggacgt      840

cacacatgta ccagaacagc aagtgtcagt catctacctg cgggtgaaca ggcttcacag      900

gcagaagagc agggtcttcc agccagctcc tgaggacagt ggccactggc tgggccatgt      960

cacaacactg ctgcagtgtg gagtacgacc agggcatggg gaattcctct tcactggaca     1020

tgtgcacttt ggggaggcac aacttggatg tgccccacgc tttagtgact ttcaaaggat     1080

gtacaggaaa gcagaagaaa tgggcataaa cccctgtgaa atcaatatgg agtgacttgc     1140

agggtgacac agtactgttg tccttcagat gagccatgtt ttgtgggctc agtcgctcta     1200

tcatatcctg atagagattg cagactggtg gcatgggccc agcctggtgc tagaactggg     1260

aaggtacatg ctgctctgac cccttaggtc ccagccaagg atgccctgac ccattggaac     1320

tgctgtaaaa tgcaaactaa gttattatat tttttttgta aaagatgcct tggtgtgcca     1380

tttaatagtg tttttacaaa gttattttca ggcattggat ttggcctggt atattggtgg     1440

gagctaggtt atggtgtgca gtgatggcta tggctcagcc ttgttattcc tgtgatggaa     1500

atgtatggag caaatacttt ctaatttccc cttcatttta ttttctattt taaaagacca     1560

tctttgccgt tgagaacctt tccagactgt atggaggctg ctcccattcc agggagtaaa     1620

gaccaggatc tgagactagt attacatcca tcttaaccca tcagatgggt acctgcattg     1680

aaccttctct gctcagctat ggcctgctgt cccaaagacc ttttgctctc tggacagttc     1740

cagatggtgc tgcctggctt aagggacttg ttcctccctt gctcctacca ggccactgtt     1800

gctttctgca tctgtcccac tgaaccagtc ttgtcctttg accctgagtt tccccaaatg     1860

cacacatcaa atccctgaat accaagggac taacctactt aatggcccat ttcttcagag     1920

ggtgtgggtt ttccctatag taagaaaatc tccacaagtt gaagcttaaa cagtaggctt     1980

tcgttcatac agtcctggaa gccagaatgg gtgtgagcag aatcacattt cctccggaga     2040

ctccaggagg gactttatag cttctggtga ctccaggaat ccttggcttg taacaatttc     2100

actctggcat tgctttccct gccatgtgac ttctgccttg tatgtgaggg cctgtatcaa     2160

atctctgtct tgggaggata cagatcattg acttagggcc cactccggtg acctcacctt     2220

cacctgaaat ttactcgatt tccatttagg tcagaggcaa aggctacaaa aaatatcaaa     2280

tccggagaaa gattcaatgg ttaggcactt gctactctta caaaggacct gtgttcgatt     2340

cccatgttgg gaactcatgt taggtggctt aaaattgcct ataactacaa ttccagggga     2400

tctagcaacc tcttctcgcc acacacaagc acacacacac acacacacac acacacacaa     2460

ttaaaaac                                                              2468


<210> 5
<211> 166
<212> PRT
<213> Homo sapiens

<400> 5
Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210> 6
<211> 1211
<212> DNA
<213> Homo sapiens

<400> 6
acattgttct gatcatctga agatcagcta ttagaagaga aagatcagtt aagtcctttg       60

gacctgatca gcttgataca agaactactg atttcaactt ctttggctta attctctcgg      120

aaacgatgaa atatacaagt tatatcttgg cttttcagct ctgcatcgtt ttgggttctc      180

ttggctgtta ctgccaggac ccatatgtaa aagaagcaga aaaccttaag aaatatttta      240

atgcaggtca ttcagatgta gcggataatg gaactctttt cttaggcatt ttgaagaatt      300

ggaaagagga gagtgacaga aaaataatgc agagccaaat tgtctccttt tacttcaaac      360

tttttaaaaa ctttaaagat gaccagagca tccaaaagag tgtggagacc atcaaggaag      420

acatgaatgt caagtttttc aatagcaaca aaaagaaacg agatgacttc gaaaagctga      480

ctaattattc ggtaactgac ttgaatgtcc aacgcaaagc aatacatgaa ctcatccaag      540

tgatggctga actgtcgcca gcagctaaaa cagggaagcg aaaaaggagt cagatgctgt      600

ttcgaggtcg aagagcatcc cagtaatggt tgtcctgcct gcaatatttg aattttaaat      660

ctaaatctat ttattaatat ttaacattat ttatatgggg aatatatttt tagactcatc      720

aatcaaataa gtatttataa tagcaacttt tgtgtaatga aaatgaatat ctattaatat      780

atgtattatt tataattcct atatcctgtg actgtctcac ttaatccttt gttttctgac      840

taattaggca aggctatgtg attacaaggc tttatctcag gggccaacta ggcagccaac      900

ctaagcaaga tcccatgggt tgtgtgttta tttcacttga tgatacaatg aacacttata      960

agtgaagtga tactatccag ttactgccgg tttgaaaata tgcctgcaat ctgagccagt     1020

gctttaatgg catgtcagac agaacttgaa tgtgtcaggt gaccctgatg aaaacatagc     1080

atctcaggag atttcatgcc tggtgcttcc aaatattgtt gacaactgtg actgtaccca     1140

aatggaaagt aactcatttg ttaaaattat caatatctaa tatatatgaa taaagtgtaa     1200

gttcacaact a                                                          1211


<210> 7
<211> 155
<212> PRT
<213> Mus musculus

<400> 7
Met Asn Ala Thr His Cys Ile Leu Ala Leu Gln Leu Phe Leu Met Ala 
1               5                   10                  15      


Val Ser Gly Cys Tyr Cys His Gly Thr Val Ile Glu Ser Leu Glu Ser 
            20                  25                  30          


Leu Asn Asn Tyr Phe Asn Ser Ser Gly Ile Asp Val Glu Glu Lys Ser 
        35                  40                  45              


Leu Phe Leu Asp Ile Trp Arg Asn Trp Gln Lys Asp Gly Asp Met Lys 
    50                  55                  60                  


Ile Leu Gln Ser Gln Ile Ile Ser Phe Tyr Leu Arg Leu Phe Glu Val 
65                  70                  75                  80  


Leu Lys Asp Asn Gln Ala Ile Ser Asn Asn Ile Ser Val Ile Glu Ser 
                85                  90                  95      


His Leu Ile Thr Thr Phe Phe Ser Asn Ser Lys Ala Lys Lys Asp Ala 
            100                 105                 110         


Phe Met Ser Ile Ala Lys Phe Glu Val Asn Asn Pro Gln Val Gln Arg 
        115                 120                 125             


Gln Ala Phe Asn Glu Leu Ile Arg Val Val His Gln Leu Leu Pro Glu 
    130                 135                 140                 


Ser Ser Leu Arg Lys Arg Lys Arg Ser Arg Cys 
145                 150                 155 


<210> 8
<211> 1210
<212> DNA
<213> Mus musculus

<400> 8
tatagctgcc atcggctgac ctagagaaga cacatcagct gatcctttgg accctctgac       60

ttgagacaga agttctgggc ttctcctcct gcggcctagc tctgagacaa tgaacgctac      120

acactgcatc ttggctttgc agctcttcct catggctgtt tctggctgtt actgccacgg      180

cacagtcatt gaaagcctag aaagtctgaa taactatttt aactcaagtg gcatagatgt      240

ggaagaaaag agtctcttct tggatatctg gaggaactgg caaaaggatg gtgacatgaa      300

aatcctgcag agccagatta tctctttcta cctcagactc tttgaagtct tgaaagacaa      360

tcaggccatc agcaacaaca taagcgtcat tgaatcacac ctgattacta ccttcttcag      420

caacagcaag gcgaaaaagg atgcattcat gagtattgcc aagtttgagg tcaacaaccc      480

acaggtccag cgccaagcat tcaatgagct catccgagtg gtccaccagc tgttgccgga      540

atccagcctc aggaagcgga aaaggagtcg ctgctgattc ggggtgggga agagattgtc      600

ccaataagaa taattctgcc agcactattt gaatttttaa atctaaacct atttattaat      660

atttaaaact atttatatgg agaatctatt ttagatgcat caaccaaaga agtatttata      720

gtaacaactt atatgtgata agagtgaatt cctattaata tatgtgttat ttataatttc      780

tgtctcctca actatttctc tttgaccaat taattattct ttctgactaa ttagccaaga      840

ctgtgattgc ggggttgtat ctgggggtgg gggacagcca agcggctgac tgaactcaga      900

ttgtagcttg tacctttact tcactgacca ataagaaaca ttcagagctg cagtgacccc      960

gggaggtgct gctgatggga ggagatgtct acactccggg ccagcgcttt aacagcaggc     1020

cagacagcac tcgaatgtgt caggtagtaa caggctgtcc ctgaaagaaa gcagtgtctc     1080

aagagacttg acacctggtg cttccctata cagctgaaaa ctgtgactac acccgaatga     1140

caaataactc gctcatttat agtttatcac tgtctaattg catatgaata aagtatacct     1200

ttgcaaccaa                                                            1210


<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 10
His His His His His His 
1               5       


<210> 11
<211> 153
<212> PRT
<213> Homo sapiens

<400> 11
Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210> 12
<211> 462
<212> DNA
<213> Homo sapiens

<400> 12
atgggtctca cctcccaact gcttccccct ctgttcttcc tgctagcatg tgccggcaac       60

tttgtccacg gacacaagtg cgatatcacc ttacaggaga tcatcaaaac tttgaacagc      120

ctcacagagc agaagactct gtgcaccgag ttgaccgtaa cagacatctt tgctgcctcc      180

aagaacacaa ctgagaagga aaccttctgc agggctgcga ctgtgctccg gcagttctac      240

agccaccatg agaaggacac tcgctgcctg ggtgcgactg cacagcagtt ccacaggcac      300

aagcagctga tccgattcct gaaacggctc gacaggaacc tctggggcct ggcgggcttg      360

aattcctgtc ctgtgaagga agccaaccag agtacgttgg aaaacttctt ggaaaggcta      420

aagacgatca tgagagagaa atattcaaag tgttcgagct ga                         462


<210> 13
<211> 140
<212> PRT
<213> Mus musculus

<400> 13
Met Gly Leu Asn Pro Gln Leu Val Val Ile Leu Leu Phe Phe Leu Glu 
1               5                   10                  15      


Cys Thr Arg Ser His Ile His Gly Cys Asp Lys Asn His Leu Arg Glu 
            20                  25                  30          


Ile Ile Gly Ile Leu Asn Glu Val Thr Gly Glu Gly Thr Pro Cys Thr 
        35                  40                  45              


Glu Met Asp Val Pro Asn Val Leu Thr Ala Thr Lys Asn Thr Thr Glu 
    50                  55                  60                  


Ser Glu Leu Val Cys Arg Ala Ser Lys Val Leu Arg Ile Phe Tyr Leu 
65                  70                  75                  80  


Lys His Gly Lys Thr Pro Cys Leu Lys Lys Asn Ser Ser Val Leu Met 
                85                  90                  95      


Glu Leu Gln Arg Leu Phe Arg Ala Phe Arg Cys Leu Asp Ser Ser Ile 
            100                 105                 110         


Ser Cys Thr Met Asn Glu Ser Lys Ser Thr Ser Leu Lys Asp Phe Leu 
        115                 120                 125             


Glu Ser Leu Lys Ser Ile Met Gln Met Asp Tyr Ser 
    130                 135                 140 


<210> 14
<211> 423
<212> DNA
<213> Mus musculus

<400> 14
atgggtctca acccccagct agttgtcatc ctgctcttct ttctcgaatg taccaggagc       60

catatccacg gatgcgacaa aaatcacttg agagagatca tcggcatttt gaacgaggtc      120

acaggagaag ggacgccatg cacggagatg gatgtgccaa acgtcctcac agcaacgaag      180

aacaccacag agagtgagct cgtctgtagg gcttccaagg tgcttcgcat attttattta      240

aaacatggga aaactccatg cttgaagaag aactctagtg ttctcatgga gctgcagaga      300

ctctttcggg cttttcgatg cctggattca tcgataagct gcaccatgaa tgagtccaag      360

tccacatcac tgaaagactt cctggaaagc ctaaagagca tcatgcaaat ggattactcg      420

tag                                                                    423


<210> 15
<211> 178
<212> PRT
<213> Homo sapiens

<400> 15
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 16
<211> 537
<212> DNA
<213> Homo sapiens

<400> 16
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggccagccca       60

ggccagggca cccagtctga gaacagctgc acccacttcc caggcaacct gcctaacatg      120

cttcgagatc tccgagatgc cttcagcaga gtgaagactt tctttcaaat gaaggatcag      180

ctggacaact tgttgttaaa ggagtccttg ctggaggact ttaagggtta cctgggttgc      240

caagccttgt ctgagatgat ccagttttac ctggaggagg tgatgcccca agctgagaac      300

caagacccag acatcaaggc gcatgtgaac tccctggggg agaacctgaa gaccctcagg      360

ctgaggctac ggcgctgtca tcgatttctt ccctgtgaaa acaagagcaa ggccgtggag      420

caggtgaaga atgcctttaa taagctccaa gagaaaggca tctacaaagc catgagtgag      480

tttgacatct tcatcaacta catagaagcc tacatgacaa tgaagatacg aaactga         537


<210> 17
<211> 178
<212> PRT
<213> Mus musculus

<400> 17
Met Pro Gly Ser Ala Leu Leu Cys Cys Leu Leu Leu Leu Thr Gly Met 
1               5                   10                  15      


Arg Ile Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His 
            20                  25                  30          


Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe 
        35                  40                  45              


Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile 
    50                  55                  60                  


Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu 
            100                 105                 110         


Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser 
    130                 135                 140                 


Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met 
                165                 170                 175     


Lys Ser 
        


<210> 18
<211> 537
<212> DNA
<213> Mus musculus

<400> 18
atgcctggct cagcactgct atgctgcctg ctcttactga ctggcatgag gatcagcagg       60

ggccagtaca gccgggaaga caataactgc acccacttcc cagtcggcca gagccacatg      120

ctcctagagc tgcggactgc cttcagccag gtgaagactt tctttcaaac aaaggaccag      180

ctggacaaca tactgctaac cgactcctta atgcaggact ttaagggtta cttgggttgc      240

caagccttat cggaaatgat ccagttttac ctggtagaag tgatgcccca ggcagagaag      300

catggcccag aaatcaagga gcatttgaat tccctgggtg agaagctgaa gaccctcagg      360

atgcggctga ggcgctgtca tcgatttctc ccctgtgaaa ataagagcaa ggcagtggag      420

caggtgaaga gtgattttaa taagctccaa gaccaaggtg tctacaaggc catgaatgaa      480

tttgacatct tcatcaactg catagaagca tacatgatga tcaaaatgaa aagctaa         537


<210> 19
<211> 390
<212> PRT
<213> Homo sapiens

<400> 19
Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210> 20
<211> 1173
<212> DNA
<213> Homo sapiens

<400> 20
atgccgccct ccgggctgcg gctgctgccg ctgctgctac cgctgctgtg gctactggtg       60

ctgacgcctg gccggccggc cgcgggacta tccacctgca agactatcga catggagctg      120

gtgaagcgga agcgcatcga ggccatccgc ggccagatcc tgtccaagct gcggctcgcc      180

agccccccga gccaggggga ggtgccgccc ggcccgctgc ccgaggccgt gctcgccctg      240

tacaacagca cccgcgaccg ggtggccggg gagagtgcag aaccggagcc cgagcctgag      300

gccgactact acgccaagga ggtcacccgc gtgctaatgg tggaaaccca caacgaaatc      360

tatgacaagt tcaagcagag tacacacagc atatatatgt tcttcaacac atcagagctc      420

cgagaagcgg tacctgaacc cgtgttgctc tcccgggcag agctgcgtct gctgaggctc      480

aagttaaaag tggagcagca cgtggagctg taccagaaat acagcaacaa ttcctggcga      540

tacctcagca accggctgct ggcacccagc gactcgccag agtggttatc ttttgatgtc      600

accggagttg tgcggcagtg gttgagccgt ggaggggaaa ttgagggctt tcgccttagc      660

gcccactgct cctgtgacag cagggataac acactgcaag tggacatcaa cgggttcact      720

accggccgcc gaggtgacct ggccaccatt catggcatga accggccttt cctgcttctc      780

atggccaccc cgctggagag ggcccagcat ctgcaaagct cccggcaccg ccgagccctg      840

gacaccaact attgcttcag ctccacggag aagaactgct gcgtgcggca gctgtacatt      900

gacttccgca aggacctcgg ctggaagtgg atccacgagc ccaagggcta ccatgccaac      960

ttctgcctcg ggccctgccc ctacatttgg agcctggaca cgcagtacag caaggtcctg     1020

gccctgtaca accagcataa cccgggcgcc tcggcggcgc cgtgctgcgt gccgcaggcg     1080

ctggagccgc tgcccatcgt gtactacgtg ggccgcaagc ccaaggtgga gcagctgtcc     1140

aacatgatcg tgcgctcctg caagtgcagc tga                                  1173


<210> 21
<211> 390
<212> PRT
<213> Mus musculus

<400> 21
Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Pro 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Asp Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Asp Arg Asn Asn Ala Ile Tyr Glu Lys Thr Lys Asp Ile Ser 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Asp Ile Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Pro Leu Leu Ser Arg Ala Glu Leu Arg Leu Gln Arg Leu 
145                 150                 155                 160 


Lys Ser Ser Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Gly Asn Arg Leu Leu Thr Pro Thr Asp Thr 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Asn Gln Gly Asp Gly Ile Gln Gly Phe Arg Phe Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Lys Asp Asn Lys Leu His Val Glu Ile Asn Gly Ile Ser 
225                 230                 235                 240 


Pro Lys Arg Arg Gly Asp Leu Gly Thr Ile His Asp Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu His 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ser Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210> 22
<211> 1173
<212> DNA
<213> Mus musculus

<400> 22
atgccgccct cggggctgcg gctactgccg cttctgctcc cactcccgtg gcttctagtg       60

ctgacgcccg ggaggccagc cgcgggactc tccacctgca agaccatcga catggagctg      120

gtgaaacgga agcgcatcga agccatccgt ggccagatcc tgtccaaact aaggctcgcc      180

agtcccccaa gccaggggga ggtaccgccc ggcccgctgc ccgaggcggt gctcgctttg      240

tacaacagca cccgcgaccg ggtggcaggc gagagcgccg acccagagcc ggagcccgaa      300

gcggactact atgctaaaga ggtcacccgc gtgctaatgg tggaccgcaa caacgccatc      360

tatgagaaaa ccaaagacat ctcacacagt atatatatgt tcttcaatac gtcagacatt      420

cgggaagcag tgcccgaacc cccattgctg tcccgtgcag agctgcgctt gcagagatta      480

aaatcaagtg tggagcaaca tgtggaactc taccagaaat atagcaacaa ttcctggcgt      540

taccttggta accggctgct gacccccact gatacgcctg agtggctgtc ttttgacgtc      600

actggagttg tacggcagtg gctgaaccaa ggagacggaa tacagggctt tcgattcagc      660

gctcactgct cttgtgacag caaagataac aaactccacg tggaaatcaa cgggatcagc      720

cccaaacgtc ggggcgacct gggcaccatc catgacatga accggccctt cctgctcctc      780

atggccaccc ccctggaaag ggcccagcac ctgcacagct cacggcaccg gagagccctg      840

gataccaact attgcttcag ctccacagag aagaactgct gtgtgcggca gctgtacatt      900

gactttagga aggacctggg ttggaagtgg atccacgagc ccaagggcta ccatgccaac      960

ttctgtctgg gaccctgccc ctatatttgg agcctggaca cacagtacag caaggtcctt     1020

gccctctaca accaacacaa cccgggcgct tcggcgtcac cgtgctgcgt gccgcaggct     1080

ttggagccac tgcccatcgt ctactacgtg ggtcgcaagc ccaaggtgga gcagttgtcc     1140

aacatgattg tgcgctcctg caagtgcagc tga                                  1173


<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
1               5                   


<210> 24
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 26
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp 
1               5                   10      


<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 28
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(5)
<223> Any amino acid

<220>
<221> SITE
<222> (3)..(5) 
<223> /note="This region may encompass 1-3 residues"

<400> 29
Cys Cys Xaa Xaa Xaa Cys Cys 
1               5           


<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Cys Cys Pro Gly Cys Cys 
1               5       


