                         SEQUENCE LISTING

<110>  Minerva Biotechnologies Corporation
 
<120>  ANTI-NME ANTIBODY AND METHOD OF TREATING CANCER OR CANCER 
       METASTASIS

<130>  13150-70159PCT

<140>  PCT/US2020/016570
<141>  2020-02-04

<160>  1051  

<170>  PatentIn version 3.5

<210>  1
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 Receptor - Mucin 1 precursor, Genbank Accession number: 
       P15941

<400>  1

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            580                 585                 590         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                805                 810                 815     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            820                 825                 830         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        835                 840                 845             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    850                 855                 860                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
865                 870                 875                 880 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                885                 890                 895     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            900                 905                 910         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        915                 920                 925             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
    930                 935                 940                 


Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
945                 950                 955                 960 


Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                965                 970                 975     


Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
            980                 985                 990         


Ser Ile Pro Ser His His Ser Asp  Thr Pro Thr Thr Leu  Ala Ser His 
        995                 1000                 1005             


Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His His Ser  Ser Val Pro 
    1010                 1015                 1020             


Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser Pro Gln  Leu Ser Thr 
    1025                 1030                 1035             


Gly Val  Ser Phe Phe Phe Leu  Ser Phe His Ile Ser  Asn Leu Gln 
    1040                 1045                 1050             


Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr Asp Tyr  Tyr Gln Glu 
    1055                 1060                 1065             


Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu Gln Ile  Tyr Lys Gln 
    1070                 1075                 1080             


Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys Phe Arg  Pro Gly Ser 
    1085                 1090                 1095             


Val Val  Val Gln Leu Thr Leu  Ala Phe Arg Glu Gly  Thr Ile Asn 
    1100                 1105                 1110             


Val His  Asp Val Glu Thr Gln  Phe Asn Gln Tyr Lys  Thr Glu Ala 
    1115                 1120                 1125             


Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp Val Ser  Val Ser Asp 
    1130                 1135                 1140             


Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly Ala Gly  Val Pro Gly 
    1145                 1150                 1155             


Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys Val Leu  Val Ala Leu 
    1160                 1165                 1170             


Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val Cys Gln  Cys Arg Arg 
    1175                 1180                 1185             


Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro Ala Arg  Asp Thr Tyr 
    1190                 1195                 1200             


His Pro  Met Ser Glu Tyr Pro  Thr Tyr His Thr His  Gly Arg Tyr 
    1205                 1210                 1215             


Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro Tyr Glu  Lys Val Ser 
    1220                 1225                 1230             


Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr Thr Asn  Pro Ala Val 
    1235                 1240                 1245             


Ala Ala  Ala Ser Ala Asn Leu  
    1250                 1255 


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal MUC-1 signaling sequence

<400>  2

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr 
            


<210>  3
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal MUC-1 signaling sequence

<400>  3

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Ala 
            20              


<210>  4
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal MUC-1 signaling sequence

<400>  4

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly 
            20              


<210>  5
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated MUC1 receptor isoform having nat-PSMGFR at its 
       N-terminus and including the transmembrane and cytoplasmic 
       sequences of a full-length MUC1 receptor

<400>  5

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu 
    50                  55                  60                  


Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys 
65                  70                  75                  80  


Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro 
                85                  90                  95      


Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro 
            100                 105                 110         


Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly 
        115                 120                 125             


Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Ala Ser Ala 
    130                 135                 140                 


Asn Leu 
145     


<210>  6
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMGFR sequence

<400>  6

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  45  


<210>  7
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMGFR sequence

<400>  7

Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
1               5                   10                  15      


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
            20                  25                  30          


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  


<210>  8
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMGFR sequence

<400>  8

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Pro Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  45  


<210>  9
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMGFR sequence

<400>  9

Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
1               5                   10                  15      


Glu Ala Ala Ser Pro Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
            20                  25                  30          


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  


<210>  10
<211>  216
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MUC1 cytoplasmic domain nucleotide sequence

<400>  10
tgtcagtgcc gccgaaagaa ctacgggcag ctggacatct ttccagcccg ggatacctac       60

catcctatga gcgagtaccc cacctaccac acccatgggc gctatgtgcc ccctagcagt      120

accgatcgta gcccctatga gaaggtttct gcaggtaacg gtggcagcag cctctcttac      180

acaaacccag cagtggcagc cgcttctgcc aacttg                                216


<210>  11
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 cytoplasmic domain amino acid sequence

<400>  11

Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
1               5                   10                  15      


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
            20                  25                  30          


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
        35                  40                  45              


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
    50                  55                  60                  


Val Ala Ala Ala Ser Ala Asn Leu 
65                  70          


<210>  12
<211>  854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NME7 nucleotide sequence (NME7: GENBANK ACCESSION AB209049)

<400>  12
gagatcctga gacaatgaat catagtgaaa gattcgtttt cattgcagag tggtatgatc       60

caaatgcttc acttcttcga cgttatgagc ttttatttta cccaggggat ggatctgttg      120

aaatgcatga tgtaaagaat catcgcacct ttttaaagcg gaccaaatat gataacctgc      180

acttggaaga tttatttata ggcaacaaag tgaatgtctt ttctcgacaa ctggtattaa      240

ttgactatgg ggatcaatat acagctcgcc agctgggcag taggaaagaa aaaacgctag      300

ccctaattaa accagatgca atatcaaagg ctggagaaat aattgaaata ataaacaaag      360

ctggatttac tataaccaaa ctcaaaatga tgatgctttc aaggaaagaa gcattggatt      420

ttcatgtaga tcaccagtca agaccctttt tcaatgagct gatccagttt attacaactg      480

gtcctattat tgccatggag attttaagag atgatgctat atgtgaatgg aaaagactgc      540

tgggacctgc aaactctgga gtggcacgca cagatgcttc tgaaagcatt agagccctct      600

ttggaacaga tggcataaga aatgcagcgc atggccctga ttcttttgct tctgcggcca      660

gagaaatgga gttgtttttt ccttcaagtg gaggttgtgg gccggcaaac actgctaaat      720

ttactaattg tacctgttgc attgttaaac cccatgctgt cagtgaaggt atgttgaata      780

cactatattc agtacatttt gttaatagga gagcaatgtt tattttcttg atgtacttta      840

tgtatagaaa ataa                                                        854


<210>  13
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7 amino acid sequence (NME7: GENBANK ACCESSION AB209049)

<400>  13

Asp Pro Glu Thr Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu 
1               5                   10                  15      


Trp Tyr Asp Pro Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe 
            20                  25                  30          


Tyr Pro Gly Asp Gly Ser Val Glu Met His Asp Val Lys Asn His Arg 
        35                  40                  45              


Thr Phe Leu Lys Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu 
    50                  55                  60                  


Phe Ile Gly Asn Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile 
65                  70                  75                  80  


Asp Tyr Gly Asp Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu 
                85                  90                  95      


Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu 
            100                 105                 110         


Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys 
        115                 120                 125             


Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His 
    130                 135                 140                 


Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly 
145                 150                 155                 160 


Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp 
                165                 170                 175     


Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala 
            180                 185                 190         


Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala 
        195                 200                 205             


Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu 
    210                 215                 220                 


Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe 
225                 230                 235                 240 


Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
                245                 250                 255     


Met Leu Asn Thr Leu Tyr Ser Val His Phe Val Asn Arg Arg Ala Met 
            260                 265                 270         


Phe Ile Phe Leu Met Tyr Phe Met Tyr Arg Lys 
        275                 280             


<210>  14
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NM23-H1 nucleotide sequence (NM23-H1: GENBANK ACCESSION AF487339)

<400>  14
atggtgctac tgtctacttt agggatcgtc tttcaaggcg aggggcctcc tatctcaagc       60

tgtgatacag gaaccatggc caactgtgag cgtaccttca ttgcgatcaa accagatggg      120

gtccagcggg gtcttgtggg agagattatc aagcgttttg agcagaaagg attccgcctt      180

gttggtctga aattcatgca agcttccgaa gatcttctca aggaacacta cgttgacctg      240

aaggaccgtc cattctttgc cggcctggtg aaatacatgc actcagggcc ggtagttgcc      300

atggtctggg aggggctgaa tgtggtgaag acgggccgag tcatgctcgg ggagaccaac      360

cctgcagact ccaagcctgg gaccatccgt ggagacttct gcatacaagt tggcaggaac      420

attatacatg gcagtgattc tgtggagagt gcagagaagg agatcggctt gtggtttcac      480

cctgaggaac tggtagatta cacgagctgt gctcagaact ggatctatga atga            534


<210>  15
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NM23-H1 describes amino acid sequence (NM23-H1: GENBANK ACCESSION
       AF487339)

<400>  15

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile Ile His Gly 
    130                 135                 140                 


Ser Asp Ser Val Glu Ser Ala Glu Lys Glu Ile Gly Leu Trp Phe His 
145                 150                 155                 160 


Pro Glu Glu Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 
                165                 170                 175     


Glu 
    


<210>  16
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NM23-H1 S120G mutant nucleotide sequence (NM23-H1: GENBANK 
       ACCESSION AF487339)

<400>  16
atggtgctac tgtctacttt agggatcgtc tttcaaggcg aggggcctcc tatctcaagc       60

tgtgatacag gaaccatggc caactgtgag cgtaccttca ttgcgatcaa accagatggg      120

gtccagcggg gtcttgtggg agagattatc aagcgttttg agcagaaagg attccgcctt      180

gttggtctga aattcatgca agcttccgaa gatcttctca aggaacacta cgttgacctg      240

aaggaccgtc cattctttgc cggcctggtg aaatacatgc actcagggcc ggtagttgcc      300

atggtctggg aggggctgaa tgtggtgaag acgggccgag tcatgctcgg ggagaccaac      360

cctgcagact ccaagcctgg gaccatccgt ggagacttct gcatacaagt tggcaggaac      420

attatacatg gcggtgattc tgtggagagt gcagagaagg agatcggctt gtggtttcac      480

cctgaggaac tggtagatta cacgagctgt gctcagaact ggatctatga atga            534


<210>  17
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NM23-H1 S120G mutant amino acid sequence (NM23-H1: GENBANK 
       ACCESSION AF487339)

<400>  17

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile Ile His Gly 
    130                 135                 140                 


Gly Asp Ser Val Glu Ser Ala Glu Lys Glu Ile Gly Leu Trp Phe His 
145                 150                 155                 160 


Pro Glu Glu Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 
                165                 170                 175     


Glu 
    


<210>  18
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NM23-H2 nucleotide sequence (NM23-H2: GENBANK ACCESSION AK313448)

<400>  18
atggccaacc tggagcgcac cttcatcgcc atcaagccgg acggcgtgca gcgcggcctg       60

gtgggcgaga tcatcaagcg cttcgagcag aagggattcc gcctcgtggc catgaagttc      120

ctccgggcct ctgaagaaca cctgaagcag cactacattg acctgaaaga ccgaccattc      180

ttccctgggc tggtgaagta catgaactca gggccggttg tggccatggt ctgggagggg      240

ctgaacgtgg tgaagacagg ccgagtgatg cttggggaga ccaatccagc agattcaaag      300

ccaggcacca ttcgtgggga cttctgcatt caggttggca ggaacatcat tcatggcagt      360

gattcagtaa aaagtgctga aaaagaaatc agcctatggt ttaagcctga agaactggtt      420

gactacaagt cttgtgctca tgactgggtc tatgaataa                             459


<210>  19
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NM23-H2 amino acid sequence (NM23-H2: GENBANK ACCESSION AK313448)

<400>  19

Met Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu 
        35                  40                  45              


Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Ser Leu Trp Phe Lys Pro Glu Glu Leu Val Asp Tyr Lys Ser 
    130                 135                 140                 


Cys Ala His Asp Trp Val Tyr Glu 
145                 150         


<210>  20
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NM23-H7-2 sequence optimized for E. coli expression

<400>  20
atgcatgacg ttaaaaatca ccgtaccttt ctgaaacgca cgaaatatga taatctgcat       60

ctggaagacc tgtttattgg caacaaagtc aatgtgttct ctcgtcagct ggtgctgatc      120

gattatggcg accagtacac cgcgcgtcaa ctgggtagtc gcaaagaaaa aacgctggcc      180

ctgattaaac cggatgcaat ctccaaagct ggcgaaatta tcgaaattat caacaaagcg      240

ggtttcacca tcacgaaact gaaaatgatg atgctgagcc gtaaagaagc cctggatttt      300

catgtcgacc accagtctcg cccgtttttc aatgaactga ttcaattcat caccacgggt      360

ccgattatcg caatggaaat tctgcgtgat gacgctatct gcgaatggaa acgcctgctg      420

ggcccggcaa actcaggtgt tgcgcgtacc gatgccagtg aatccattcg cgctctgttt      480

ggcaccgatg gtatccgtaa tgcagcacat ggtccggact cattcgcatc ggcagctcgt      540

gaaatggaac tgtttttccc gagctctggc ggttgcggtc cggcaaacac cgccaaattt      600

accaattgta cgtgctgtat tgtcaaaccg cacgcagtgt cagaaggcct gctgggtaaa      660

attctgatgg caatccgtga tgctggcttt gaaatctcgg ccatgcagat gttcaacatg      720

gaccgcgtta acgtcgaaga attctacgaa gtttacaaag gcgtggttac cgaatatcac      780

gatatggtta cggaaatgta ctccggtccg tgcgtcgcga tggaaattca gcaaaacaat      840

gccaccaaaa cgtttcgtga attctgtggt ccggcagatc cggaaatcgc acgtcatctg      900

cgtccgggta ccctgcgcgc aatttttggt aaaacgaaaa tccagaacgc tgtgcactgt      960

accgatctgc cggaagacgg tctgctggaa gttcaatact ttttcaaaat tctggataat     1020

tga                                                                   1023


<210>  21
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NM23-H7-2 sequence optimized for E. coli expression

<400>  21

Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys Arg Thr Lys Tyr 
1               5                   10                  15      


Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn Lys Val Asn Val 
            20                  25                  30          


Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp Gln Tyr Thr Ala 
        35                  40                  45              


Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala Leu Ile Lys Pro 
    50                  55                  60                  


Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala 
65                  70                  75                  80  


Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu Ser Arg Lys Glu 
                85                  90                  95      


Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro Phe Phe Asn Glu 
            100                 105                 110         


Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala Met Glu Ile Leu 
        115                 120                 125             


Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn 
    130                 135                 140                 


Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe 
145                 150                 155                 160 


Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro Asp Ser Phe Ala 
                165                 170                 175     


Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys 
            180                 185                 190         


Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr Cys Cys Ile Val 
        195                 200                 205             


Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys Ile Leu Met Ala 
    210                 215                 220                 


Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln Met Phe Asn Met 
225                 230                 235                 240 


Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr Lys Gly Val Val 
                245                 250                 255     


Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser Gly Pro Cys Val 
            260                 265                 270         


Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe 
        275                 280                 285             


Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg Pro Gly Thr 
    290                 295                 300                 


Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Cys 
305                 310                 315                 320 


Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys 
                325                 330                 335     


Ile Leu Asp Asn 
            340 


<210>  22
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-A

<400>  22
atggaaaaaa cgctagccct aattaaacca gatgcaatat caaaggctgg agaaataatt       60

gaaataataa acaaagctgg atttactata accaaactca aaatgatgat gctttcaagg      120

aaagaagcat tggattttca tgtagatcac cagtcaagac cctttttcaa tgagctgatc      180

cagtttatta caactggtcc tattattgcc atggagattt taagagatga tgctatatgt      240

gaatggaaaa gactgctggg acctgcaaac tctggagtgg cacgcacaga tgcttctgaa      300

agcattagag ccctctttgg aacagatggc ataagaaatg cagcgcatgg ccctgattct      360

tttgcttctg cggccagaga aatggagttg tttttttga                             399


<210>  23
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A

<400>  23

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe 
    130         


<210>  24
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-A1

<400>  24
atggaaaaaa cgctagccct aattaaacca gatgcaatat caaaggctgg agaaataatt       60

gaaataataa acaaagctgg atttactata accaaactca aaatgatgat gctttcaagg      120

aaagaagcat tggattttca tgtagatcac cagtcaagac cctttttcaa tgagctgatc      180

cagtttatta caactggtcc tattattgcc atggagattt taagagatga tgctatatgt      240

gaatggaaaa gactgctggg acctgcaaac tctggagtgg cacgcacaga tgcttctgaa      300

agcattagag ccctctttgg aacagatggc ataagaaatg cagcgcatgg ccctgattct      360

tttgcttctg cggccagaga aatggagttg ttttttcctt caagtggagg ttgtgggccg      420

gcaaacactg ctaaatttac ttga                                             444


<210>  25
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A1

<400>  25

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr 
145         


<210>  26
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-A2

<400>  26
atgaatcata gtgaaagatt cgttttcatt gcagagtggt atgatccaaa tgcttcactt       60

cttcgacgtt atgagctttt attttaccca ggggatggat ctgttgaaat gcatgatgta      120

aagaatcatc gcaccttttt aaagcggacc aaatatgata acctgcactt ggaagattta      180

tttataggca acaaagtgaa tgtcttttct cgacaactgg tattaattga ctatggggat      240

caatatacag ctcgccagct gggcagtagg aaagaaaaaa cgctagccct aattaaacca      300

gatgcaatat caaaggctgg agaaataatt gaaataataa acaaagctgg atttactata      360

accaaactca aaatgatgat gctttcaagg aaagaagcat tggattttca tgtagatcac      420

cagtcaagac cctttttcaa tgagctgatc cagtttatta caactggtcc tattattgcc      480

atggagattt taagagatga tgctatatgt gaatggaaaa gactgctggg acctgcaaac      540

tctggagtgg cacgcacaga tgcttctgaa agcattagag ccctctttgg aacagatggc      600

ataagaaatg cagcgcatgg ccctgattct tttgcttctg cggccagaga aatggagttg      660

tttttttga                                                              669


<210>  27
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A2

<400>  27

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe 
    210                 215                 220         


<210>  28
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-A3

<400>  28
atgaatcata gtgaaagatt cgttttcatt gcagagtggt atgatccaaa tgcttcactt       60

cttcgacgtt atgagctttt attttaccca ggggatggat ctgttgaaat gcatgatgta      120

aagaatcatc gcaccttttt aaagcggacc aaatatgata acctgcactt ggaagattta      180

tttataggca acaaagtgaa tgtcttttct cgacaactgg tattaattga ctatggggat      240

caatatacag ctcgccagct gggcagtagg aaagaaaaaa cgctagccct aattaaacca      300

gatgcaatat caaaggctgg agaaataatt gaaataataa acaaagctgg atttactata      360

accaaactca aaatgatgat gctttcaagg aaagaagcat tggattttca tgtagatcac      420

cagtcaagac cctttttcaa tgagctgatc cagtttatta caactggtcc tattattgcc      480

atggagattt taagagatga tgctatatgt gaatggaaaa gactgctggg acctgcaaac      540

tctggagtgg cacgcacaga tgcttctgaa agcattagag ccctctttgg aacagatggc      600

ataagaaatg cagcgcatgg ccctgattct tttgcttctg cggccagaga aatggagttg      660

ttttttcctt caagtggagg ttgtgggccg gcaaacactg ctaaatttac ttga            714


<210>  29
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A3

<400>  29

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
225                 230                 235         


<210>  30
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-B

<400>  30
atgaattgta cctgttgcat tgttaaaccc catgctgtca gtgaaggact gttgggaaag       60

atcctgatgg ctatccgaga tgcaggtttt gaaatctcag ctatgcagat gttcaatatg      120

gatcgggtta atgttgagga attctatgaa gtttataaag gagtagtgac cgaatatcat      180

gacatggtga cagaaatgta ttctggccct tgtgtagcaa tggagattca acagaataat      240

gctacaaaga catttcgaga attttgtgga cctgctgatc ctgaaattgc ccggcattta      300

cgccctggaa ctctcagagc aatctttggt aaaactaaga tccagaatgc tgttcactgt      360

actgatctgc cagaggatgg cctattagag gttcaatact tcttctga                   408


<210>  31
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B

<400>  31

Met Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
1               5                   10                  15      


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
            20                  25                  30          


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
        35                  40                  45              


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
    50                  55                  60                  


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
65                  70                  75                  80  


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
                85                  90                  95      


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
            100                 105                 110         


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
        115                 120                 125             


Leu Glu Val Gln Tyr Phe Phe 
    130                 135 


<210>  32
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-B1

<400>  32
atgaattgta cctgttgcat tgttaaaccc catgctgtca gtgaaggact gttgggaaag       60

atcctgatgg ctatccgaga tgcaggtttt gaaatctcag ctatgcagat gttcaatatg      120

gatcgggtta atgttgagga attctatgaa gtttataaag gagtagtgac cgaatatcat      180

gacatggtga cagaaatgta ttctggccct tgtgtagcaa tggagattca acagaataat      240

gctacaaaga catttcgaga attttgtgga cctgctgatc ctgaaattgc ccggcattta      300

cgccctggaa ctctcagagc aatctttggt aaaactaaga tccagaatgc tgttcactgt      360

actgatctgc cagaggatgg cctattagag gttcaatact tcttcaagat cttggataat      420

tagtga                                                                 426


<210>  33
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B1

<400>  33

Met Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
1               5                   10                  15      


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
            20                  25                  30          


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
        35                  40                  45              


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
    50                  55                  60                  


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
65                  70                  75                  80  


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
                85                  90                  95      


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
            100                 105                 110         


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
        115                 120                 125             


Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
    130                 135                 140 


<210>  34
<211>  453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-B2

<400>  34
atgccttcaa gtggaggttg tgggccggca aacactgcta aatttactaa ttgtacctgt       60

tgcattgtta aaccccatgc tgtcagtgaa ggactgttgg gaaagatcct gatggctatc      120

cgagatgcag gttttgaaat ctcagctatg cagatgttca atatggatcg ggttaatgtt      180

gaggaattct atgaagttta taaaggagta gtgaccgaat atcatgacat ggtgacagaa      240

atgtattctg gcccttgtgt agcaatggag attcaacaga ataatgctac aaagacattt      300

cgagaatttt gtggacctgc tgatcctgaa attgcccggc atttacgccc tggaactctc      360

agagcaatct ttggtaaaac taagatccag aatgctgttc actgtactga tctgccagag      420

gatggcctat tagaggttca atacttcttc tga                                   453


<210>  35
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B2

<400>  35

Met Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
1               5                   10                  15      


Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
            20                  25                  30          


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
        35                  40                  45              


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
    50                  55                  60                  


Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
65                  70                  75                  80  


Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala 
                85                  90                  95      


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
            100                 105                 110         


Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
        115                 120                 125             


Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
    130                 135                 140                 


Glu Val Gln Tyr Phe Phe 
145                 150 


<210>  36
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-B3

<400>  36
atgccttcaa gtggaggttg tgggccggca aacactgcta aatttactaa ttgtacctgt       60

tgcattgtta aaccccatgc tgtcagtgaa ggactgttgg gaaagatcct gatggctatc      120

cgagatgcag gttttgaaat ctcagctatg cagatgttca atatggatcg ggttaatgtt      180

gaggaattct atgaagttta taaaggagta gtgaccgaat atcatgacat ggtgacagaa      240

atgtattctg gcccttgtgt agcaatggag attcaacaga ataatgctac aaagacattt      300

cgagaatttt gtggacctgc tgatcctgaa attgcccggc atttacgccc tggaactctc      360

agagcaatct ttggtaaaac taagatccag aatgctgttc actgtactga tctgccagag      420

gatggcctat tagaggttca atacttcttc aagatcttgg ataattagtg a               471


<210>  37
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B3

<400>  37

Met Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
1               5                   10                  15      


Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
            20                  25                  30          


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
        35                  40                  45              


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
    50                  55                  60                  


Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
65                  70                  75                  80  


Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala 
                85                  90                  95      


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
            100                 105                 110         


Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
        115                 120                 125             


Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
    130                 135                 140                 


Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
145                 150                 155 


<210>  38
<211>  864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB, also known as NME7AB

<400>  38
atggaaaaaa cgctagccct aattaaacca gatgcaatat caaaggctgg agaaataatt       60

gaaataataa acaaagctgg atttactata accaaactca aaatgatgat gctttcaagg      120

aaagaagcat tggattttca tgtagatcac cagtcaagac cctttttcaa tgagctgatc      180

cagtttatta caactggtcc tattattgcc atggagattt taagagatga tgctatatgt      240

gaatggaaaa gactgctggg acctgcaaac tctggagtgg cacgcacaga tgcttctgaa      300

agcattagag ccctctttgg aacagatggc ataagaaatg cagcgcatgg ccctgattct      360

tttgcttctg cggccagaga aatggagttg ttttttcctt caagtggagg ttgtgggccg      420

gcaaacactg ctaaatttac taattgtacc tgttgcattg ttaaacccca tgctgtcagt      480

gaaggactgt tgggaaagat cctgatggct atccgagatg caggttttga aatctcagct      540

atgcagatgt tcaatatgga tcgggttaat gttgaggaat tctatgaagt ttataaagga      600

gtagtgaccg aatatcatga catggtgaca gaaatgtatt ctggcccttg tgtagcaatg      660

gagattcaac agaataatgc tacaaagaca tttcgagaat tttgtggacc tgctgatcct      720

gaaattgccc ggcatttacg ccctggaact ctcagagcaa tctttggtaa aactaagatc      780

cagaatgctg ttcactgtac tgatctgcca gaggatggcc tattagaggt tcaatacttc      840

ttcaagatct tggataatta gtga                                             864


<210>  39
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB, also known as NME7AB

<400>  39

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
        275                 280                 285     


<210>  40
<211>  846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB1

<400>  40
atggaaaaaa cgctagccct aattaaacca gatgcaatat caaaggctgg agaaataatt       60

gaaataataa acaaagctgg atttactata accaaactca aaatgatgat gctttcaagg      120

aaagaagcat tggattttca tgtagatcac cagtcaagac cctttttcaa tgagctgatc      180

cagtttatta caactggtcc tattattgcc atggagattt taagagatga tgctatatgt      240

gaatggaaaa gactgctggg acctgcaaac tctggagtgg cacgcacaga tgcttctgaa      300

agcattagag ccctctttgg aacagatggc ataagaaatg cagcgcatgg ccctgattct      360

tttgcttctg cggccagaga aatggagttg ttttttcctt caagtggagg ttgtgggccg      420

gcaaacactg ctaaatttac taattgtacc tgttgcattg ttaaacccca tgctgtcagt      480

gaaggactgt tgggaaagat cctgatggct atccgagatg caggttttga aatctcagct      540

atgcagatgt tcaatatgga tcgggttaat gttgaggaat tctatgaagt ttataaagga      600

gtagtgaccg aatatcatga catggtgaca gaaatgtatt ctggcccttg tgtagcaatg      660

gagattcaac agaataatgc tacaaagaca tttcgagaat tttgtggacc tgctgatcct      720

gaaattgccc ggcatttacg ccctggaact ctcagagcaa tctttggtaa aactaagatc      780

cagaatgctg ttcactgtac tgatctgcca gaggatggcc tattagaggt tcaatacttc      840

ttctga                                                                 846


<210>  41
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB1

<400>  41

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe 
        275                 280     


<210>  42
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-A sequence optimized for E. coli expression

<400>  42
atggaaaaaa cgctggccct gattaaaccg gatgcaatct ccaaagctgg cgaaattatc       60

gaaattatca acaaagcggg tttcaccatc acgaaactga aaatgatgat gctgagccgt      120

aaagaagccc tggattttca tgtcgaccac cagtctcgcc cgtttttcaa tgaactgatt      180

caattcatca ccacgggtcc gattatcgca atggaaattc tgcgtgatga cgctatctgc      240

gaatggaaac gcctgctggg cccggcaaac tcaggtgttg cgcgtaccga tgccagtgaa      300

tccattcgcg ctctgtttgg caccgatggt atccgtaatg cagcacatgg tccggactca      360

ttcgcatcgg cagctcgtga aatggaactg tttttctga                             399


<210>  43
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A sequence optimized for E. coli expression

<400>  43

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe 
    130         


<210>  44
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-A1 sequence optimized for E. coli expression

<400>  44
atggaaaaaa cgctggccct gattaaaccg gatgcaatct ccaaagctgg cgaaattatc       60

gaaattatca acaaagcggg tttcaccatc acgaaactga aaatgatgat gctgagccgt      120

aaagaagccc tggattttca tgtcgaccac cagtctcgcc cgtttttcaa tgaactgatt      180

caattcatca ccacgggtcc gattatcgca atggaaattc tgcgtgatga cgctatctgc      240

gaatggaaac gcctgctggg cccggcaaac tcaggtgttg cgcgtaccga tgccagtgaa      300

tccattcgcg ctctgtttgg caccgatggt atccgtaatg cagcacatgg tccggactca      360

ttcgcatcgg cagctcgtga aatggaactg tttttcccga gctctggcgg ttgcggtccg      420

gcaaacaccg ccaaatttac ctga                                             444


<210>  45
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A1 sequence optimized for E. coli expression

<400>  45

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr 
145         


<210>  46
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-A2 sequence optimized for E. coli expression

<400>  46
atgaatcact ccgaacgctt tgtttttatc gccgaatggt atgacccgaa tgcttccctg       60

ctgcgccgct acgaactgct gttttatccg ggcgatggta gcgtggaaat gcatgacgtt      120

aaaaatcacc gtacctttct gaaacgcacg aaatatgata atctgcatct ggaagacctg      180

tttattggca acaaagtcaa tgtgttctct cgtcagctgg tgctgatcga ttatggcgac      240

cagtacaccg cgcgtcaact gggtagtcgc aaagaaaaaa cgctggccct gattaaaccg      300

gatgcaatct ccaaagctgg cgaaattatc gaaattatca acaaagcggg tttcaccatc      360

acgaaactga aaatgatgat gctgagccgt aaagaagccc tggattttca tgtcgaccac      420

cagtctcgcc cgtttttcaa tgaactgatt caattcatca ccacgggtcc gattatcgca      480

atggaaattc tgcgtgatga cgctatctgc gaatggaaac gcctgctggg cccggcaaac      540

tcaggtgttg cgcgtaccga tgccagtgaa tccattcgcg ctctgtttgg caccgatggt      600

atccgtaatg cagcacatgg tccggactca ttcgcatcgg cagctcgtga aatggaactg      660

tttttctga                                                              669


<210>  47
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A2 sequence optimized for E. coli expression

<400>  47

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe 
    210                 215                 220         


<210>  48
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-A3 sequence optimized for E. coli expression

<400>  48
atgaatcact ccgaacgctt tgtttttatc gccgaatggt atgacccgaa tgcttccctg       60

ctgcgccgct acgaactgct gttttatccg ggcgatggta gcgtggaaat gcatgacgtt      120

aaaaatcacc gtacctttct gaaacgcacg aaatatgata atctgcatct ggaagacctg      180

tttattggca acaaagtcaa tgtgttctct cgtcagctgg tgctgatcga ttatggcgac      240

cagtacaccg cgcgtcaact gggtagtcgc aaagaaaaaa cgctggccct gattaaaccg      300

gatgcaatct ccaaagctgg cgaaattatc gaaattatca acaaagcggg tttcaccatc      360

acgaaactga aaatgatgat gctgagccgt aaagaagccc tggattttca tgtcgaccac      420

cagtctcgcc cgtttttcaa tgaactgatt caattcatca ccacgggtcc gattatcgca      480

atggaaattc tgcgtgatga cgctatctgc gaatggaaac gcctgctggg cccggcaaac      540

tcaggtgttg cgcgtaccga tgccagtgaa tccattcgcg ctctgtttgg caccgatggt      600

atccgtaatg cagcacatgg tccggactca ttcgcatcgg cagctcgtga aatggaactg      660

tttttcccga gctctggcgg ttgcggtccg gcaaacaccg ccaaatttac ctga            714


<210>  49
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A3 sequence optimized for E. coli expression

<400>  49

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
225                 230                 235         


<210>  50
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-B sequence optimized for E. coli expression

<400>  50
atgaattgta cgtgctgtat tgtcaaaccg cacgcagtgt cagaaggcct gctgggtaaa       60

attctgatgg caatccgtga tgctggcttt gaaatctcgg ccatgcagat gttcaacatg      120

gaccgcgtta acgtcgaaga attctacgaa gtttacaaag gcgtggttac cgaatatcac      180

gatatggtta cggaaatgta ctccggtccg tgcgtcgcga tggaaattca gcaaaacaat      240

gccaccaaaa cgtttcgtga attctgtggt ccggcagatc cggaaatcgc acgtcatctg      300

cgtccgggta ccctgcgcgc aatttttggt aaaacgaaaa tccagaacgc tgtgcactgt      360

accgatctgc cggaagacgg tctgctggaa gttcaatact ttttctga                   408


<210>  51
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B sequence optimized for E. coli expression

<400>  51

Met Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
1               5                   10                  15      


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
            20                  25                  30          


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
        35                  40                  45              


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
    50                  55                  60                  


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
65                  70                  75                  80  


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
                85                  90                  95      


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
            100                 105                 110         


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
        115                 120                 125             


Leu Glu Val Gln Tyr Phe Phe 
    130                 135 


<210>  52
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-B1 sequence optimized for E. coli expression

<400>  52
atgaattgta cgtgctgtat tgtcaaaccg cacgcagtgt cagaaggcct gctgggtaaa       60

attctgatgg caatccgtga tgctggcttt gaaatctcgg ccatgcagat gttcaacatg      120

gaccgcgtta acgtcgaaga attctacgaa gtttacaaag gcgtggttac cgaatatcac      180

gatatggtta cggaaatgta ctccggtccg tgcgtcgcga tggaaattca gcaaaacaat      240

gccaccaaaa cgtttcgtga attctgtggt ccggcagatc cggaaatcgc acgtcatctg      300

cgtccgggta ccctgcgcgc aatttttggt aaaacgaaaa tccagaacgc tgtgcactgt      360

accgatctgc cggaagacgg tctgctggaa gttcaatact ttttcaaaat tctggataat      420

tga                                                                    423


<210>  53
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B1 sequence optimized for E. coli expression

<400>  53

Met Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
1               5                   10                  15      


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
            20                  25                  30          


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
        35                  40                  45              


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
    50                  55                  60                  


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
65                  70                  75                  80  


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
                85                  90                  95      


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
            100                 105                 110         


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
        115                 120                 125             


Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
    130                 135                 140 


<210>  54
<211>  453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-B2 sequence optimized for E. coli expression

<400>  54
atgccgagct ctggcggttg cggtccggca aacaccgcca aatttaccaa ttgtacgtgc       60

tgtattgtca aaccgcacgc agtgtcagaa ggcctgctgg gtaaaattct gatggcaatc      120

cgtgatgctg gctttgaaat ctcggccatg cagatgttca acatggaccg cgttaacgtc      180

gaagaattct acgaagttta caaaggcgtg gttaccgaat atcacgatat ggttacggaa      240

atgtactccg gtccgtgcgt cgcgatggaa attcagcaaa acaatgccac caaaacgttt      300

cgtgaattct gtggtccggc agatccggaa atcgcacgtc atctgcgtcc gggtaccctg      360

cgcgcaattt ttggtaaaac gaaaatccag aacgctgtgc actgtaccga tctgccggaa      420

gacggtctgc tggaagttca atactttttc tga                                   453


<210>  55
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B2 sequence optimized for E. coli expression

<400>  55

Met Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
1               5                   10                  15      


Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
            20                  25                  30          


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
        35                  40                  45              


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
    50                  55                  60                  


Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
65                  70                  75                  80  


Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala 
                85                  90                  95      


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
            100                 105                 110         


Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
        115                 120                 125             


Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
    130                 135                 140                 


Glu Val Gln Tyr Phe Phe 
145                 150 


<210>  56
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-B3 sequence optimized for E. coli expression

<400>  56
atgccgagct ctggcggttg cggtccggca aacaccgcca aatttaccaa ttgtacgtgc       60

tgtattgtca aaccgcacgc agtgtcagaa ggcctgctgg gtaaaattct gatggcaatc      120

cgtgatgctg gctttgaaat ctcggccatg cagatgttca acatggaccg cgttaacgtc      180

gaagaattct acgaagttta caaaggcgtg gttaccgaat atcacgatat ggttacggaa      240

atgtactccg gtccgtgcgt cgcgatggaa attcagcaaa acaatgccac caaaacgttt      300

cgtgaattct gtggtccggc agatccggaa atcgcacgtc atctgcgtcc gggtaccctg      360

cgcgcaattt ttggtaaaac gaaaatccag aacgctgtgc actgtaccga tctgccggaa      420

gacggtctgc tggaagttca atactttttc aaaattctgg ataattga                   468


<210>  57
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B3 sequence optimized for E. coli expression

<400>  57

Met Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
1               5                   10                  15      


Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
            20                  25                  30          


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
        35                  40                  45              


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
    50                  55                  60                  


Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
65                  70                  75                  80  


Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala 
                85                  90                  95      


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
            100                 105                 110         


Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
        115                 120                 125             


Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
    130                 135                 140                 


Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
145                 150                 155 


<210>  58
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB, also known as NME7AB sequence optimized for E. 
       coli expression

<400>  58
atggaaaaaa cgctggccct gattaaaccg gatgcaatct ccaaagctgg cgaaattatc       60

gaaattatca acaaagcggg tttcaccatc acgaaactga aaatgatgat gctgagccgt      120

aaagaagccc tggattttca tgtcgaccac cagtctcgcc cgtttttcaa tgaactgatt      180

caattcatca ccacgggtcc gattatcgca atggaaattc tgcgtgatga cgctatctgc      240

gaatggaaac gcctgctggg cccggcaaac tcaggtgttg cgcgtaccga tgccagtgaa      300

tccattcgcg ctctgtttgg caccgatggt atccgtaatg cagcacatgg tccggactca      360

ttcgcatcgg cagctcgtga aatggaactg tttttcccga gctctggcgg ttgcggtccg      420

gcaaacaccg ccaaatttac caattgtacg tgctgtattg tcaaaccgca cgcagtgtca      480

gaaggcctgc tgggtaaaat tctgatggca atccgtgatg ctggctttga aatctcggcc      540

atgcagatgt tcaacatgga ccgcgttaac gtcgaagaat tctacgaagt ttacaaaggc      600

gtggttaccg aatatcacga tatggttacg gaaatgtact ccggtccgtg cgtcgcgatg      660

gaaattcagc aaaacaatgc caccaaaacg tttcgtgaat tctgtggtcc ggcagatccg      720

gaaatcgcac gtcatctgcg tccgggtacc ctgcgcgcaa tttttggtaa aacgaaaatc      780

cagaacgctg tgcactgtac cgatctgccg gaagacggtc tgctggaagt tcaatacttt      840

ttcaaaattc tggataattg a                                                861


<210>  59
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB, also known as NME7AB sequence optimized for E. 
       coli expression

<400>  59

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
        275                 280                 285     


<210>  60
<211>  846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB1, also known as NME7AB1 sequence optimized for E. 
       coli expression

<400>  60
atggaaaaaa cgctggccct gattaaaccg gatgcaatct ccaaagctgg cgaaattatc       60

gaaattatca acaaagcggg tttcaccatc acgaaactga aaatgatgat gctgagccgt      120

aaagaagccc tggattttca tgtcgaccac cagtctcgcc cgtttttcaa tgaactgatt      180

caattcatca ccacgggtcc gattatcgca atggaaattc tgcgtgatga cgctatctgc      240

gaatggaaac gcctgctggg cccggcaaac tcaggtgttg cgcgtaccga tgccagtgaa      300

tccattcgcg ctctgtttgg caccgatggt atccgtaatg cagcacatgg tccggactca      360

ttcgcatcgg cagctcgtga aatggaactg tttttcccga gctctggcgg ttgcggtccg      420

gcaaacaccg ccaaatttac caattgtacg tgctgtattg tcaaaccgca cgcagtgtca      480

gaaggcctgc tgggtaaaat tctgatggca atccgtgatg ctggctttga aatctcggcc      540

atgcagatgt tcaacatgga ccgcgttaac gtcgaagaat tctacgaagt ttacaaaggc      600

gtggttaccg aatatcacga tatggttacg gaaatgtact ccggtccgtg cgtcgcgatg      660

gaaattcagc aaaacaatgc caccaaaacg tttcgtgaat tctgtggtcc ggcagatccg      720

gaaatcgcac gtcatctgcg tccgggtacc ctgcgcgcaa tttttggtaa aacgaaaatc      780

cagaacgctg tgcactgtac cgatctgccg gaagacggtc tgctggaagt tcaatacttt      840

ttctga                                                                 846


<210>  61
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB1, also known as NME7AB1 sequence optimized for E. 
       coli expression

<400>  61

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe 
        275                 280     


<210>  62
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse NME6

<400>  62
atgacctcca tcttgcgaag tccccaagct cttcagctca cactagccct gatcaagcct       60

gatgcagttg cccacccact gatcctggag gctgttcatc agcagattct gagcaacaag      120

ttcctcattg tacgaacgag ggaactgcag tggaagctgg aggactgccg gaggttttac      180

cgagagcatg aagggcgttt tttctatcag cggctggtgg agttcatgac aagtgggcca      240

atccgagcct atatccttgc ccacaaagat gccatccaac tttggaggac actgatggga      300

cccaccagag tatttcgagc acgctatata gccccagatt caattcgtgg aagtttgggc      360

ctcactgaca cccgaaatac tacccatggc tcagactccg tggtttccgc cagcagagag      420

attgcagcct tcttccctga cttcagtgaa cagcgctggt atgaggagga ggaaccccag      480

ctgcggtgtg gtcctgtgca ctacagtcca gaggaaggta tccactgtgc agctgaaaca      540

ggaggccaca aacaacctaa caaaacctag                                       570


<210>  63
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse NME6

<400>  63

Met Thr Ser Ile Leu Arg Ser Pro Gln Ala Leu Gln Leu Thr Leu Ala 
1               5                   10                  15      


Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu Ile Leu Glu Ala Val 
            20                  25                  30          


His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile Val Arg Thr Arg Glu 
        35                  40                  45              


Leu Gln Trp Lys Leu Glu Asp Cys Arg Arg Phe Tyr Arg Glu His Glu 
    50                  55                  60                  


Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe Met Thr Ser Gly Pro 
65                  70                  75                  80  


Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala Ile Gln Leu Trp Arg 
                85                  90                  95      


Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala Arg Tyr Ile Ala Pro 
            100                 105                 110         


Asp Ser Ile Arg Gly Ser Leu Gly Leu Thr Asp Thr Arg Asn Thr Thr 
        115                 120                 125             


His Gly Ser Asp Ser Val Val Ser Ala Ser Arg Glu Ile Ala Ala Phe 
    130                 135                 140                 


Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu Glu Glu Glu Pro Gln 
145                 150                 155                 160 


Leu Arg Cys Gly Pro Val His Tyr Ser Pro Glu Glu Gly Ile His Cys 
                165                 170                 175     


Ala Ala Glu Thr Gly Gly His Lys Gln Pro Asn Lys Thr 
            180                 185                 


<210>  64
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6

<400>  64
atgacccaga atctggggag tgagatggcc tcaatcttgc gaagccctca ggctctccag       60

ctcactctag ccctgatcaa gcctgacgca gtcgcccatc cactgattct ggaggctgtt      120

catcagcaga ttctaagcaa caagttcctg attgtacgaa tgagagaact actgtggaga      180

aaggaagatt gccagaggtt ttaccgagag catgaagggc gttttttcta tcagaggctg      240

gtggagttca tggccagcgg gccaatccga gcctacatcc ttgcccacaa ggatgccatc      300

cagctctgga ggacgctcat gggacccacc agagtgttcc gagcacgcca tgtggcccca      360

gattctatcc gtgggagttt cggcctcact gacacccgca acaccaccca tggttcggac      420

tctgtggttt cagccagcag agagattgca gccttcttcc ctgacttcag tgaacagcgc      480

tggtatgagg aggaagagcc ccagttgcgc tgtggccctg tgtgctatag cccagaggga      540

ggtgtccact atgtagctgg aacaggaggc ctaggaccag cctga                      585


<210>  65
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6

<400>  65

Met Thr Gln Asn Leu Gly Ser Glu Met Ala Ser Ile Leu Arg Ser Pro 
1               5                   10                  15      


Gln Ala Leu Gln Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala 
            20                  25                  30          


His Pro Leu Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys 
        35                  40                  45              


Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
    50                  55                  60                  


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His 
                85                  90                  95      


Lys Asp Ala Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val 
            100                 105                 110         


Phe Arg Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly 
        115                 120                 125             


Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser 
    130                 135                 140                 


Ala Ser Arg Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg 
145                 150                 155                 160 


Trp Tyr Glu Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val Cys Tyr 
                165                 170                 175     


Ser Pro Glu Gly Gly Val His Tyr Val Ala Gly Thr Gly Gly Leu Gly 
            180                 185                 190         


Pro Ala 
        


<210>  66
<211>  525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6 1

<400>  66
atgacccaga atctggggag tgagatggcc tcaatcttgc gaagccctca ggctctccag       60

ctcactctag ccctgatcaa gcctgacgca gtcgcccatc cactgattct ggaggctgtt      120

catcagcaga ttctaagcaa caagttcctg attgtacgaa tgagagaact actgtggaga      180

aaggaagatt gccagaggtt ttaccgagag catgaagggc gttttttcta tcagaggctg      240

gtggagttca tggccagcgg gccaatccga gcctacatcc ttgcccacaa ggatgccatc      300

cagctctgga ggacgctcat gggacccacc agagtgttcc gagcacgcca tgtggcccca      360

gattctatcc gtgggagttt cggcctcact gacacccgca acaccaccca tggttcggac      420

tctgtggttt cagccagcag agagattgca gccttcttcc ctgacttcag tgaacagcgc      480

tggtatgagg aggaagagcc ccagttgcgc tgtggccctg tgtga                      525


<210>  67
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 1

<400>  67

Met Thr Gln Asn Leu Gly Ser Glu Met Ala Ser Ile Leu Arg Ser Pro 
1               5                   10                  15      


Gln Ala Leu Gln Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala 
            20                  25                  30          


His Pro Leu Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys 
        35                  40                  45              


Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
    50                  55                  60                  


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His 
                85                  90                  95      


Lys Asp Ala Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val 
            100                 105                 110         


Phe Arg Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly 
        115                 120                 125             


Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser 
    130                 135                 140                 


Ala Ser Arg Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg 
145                 150                 155                 160 


Trp Tyr Glu Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val 
                165                 170                 


<210>  68
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6 2

<400>  68
atgctcactc tagccctgat caagcctgac gcagtcgccc atccactgat tctggaggct       60

gttcatcagc agattctaag caacaagttc ctgattgtac gaatgagaga actactgtgg      120

agaaaggaag attgccagag gttttaccga gagcatgaag ggcgtttttt ctatcagagg      180

ctggtggagt tcatggccag cgggccaatc cgagcctaca tccttgccca caaggatgcc      240

atccagctct ggaggacgct catgggaccc accagagtgt tccgagcacg ccatgtggcc      300

ccagattcta tccgtgggag tttcggcctc actgacaccc gcaacaccac ccatggttcg      360

gactctgtgg tttcagccag cagagagatt gcagccttct tccctgactt cagtgaacag      420

cgctggtatg aggaggaaga gccccagttg cgctgtggcc ctgtgtga                   468


<210>  69
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 2

<400>  69

Met Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu 
1               5                   10                  15      


Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile 
            20                  25                  30          


Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe 
        35                  40                  45              


Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
    50                  55                  60                  


Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala 
65                  70                  75                  80  


Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala 
                85                  90                  95      


Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp 
            100                 105                 110         


Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg 
        115                 120                 125             


Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu 
    130                 135                 140                 


Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val 
145                 150                 155 


<210>  70
<211>  528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6 3

<400>  70
atgctcactc tagccctgat caagcctgac gcagtcgccc atccactgat tctggaggct       60

gttcatcagc agattctaag caacaagttc ctgattgtac gaatgagaga actactgtgg      120

agaaaggaag attgccagag gttttaccga gagcatgaag ggcgtttttt ctatcagagg      180

ctggtggagt tcatggccag cgggccaatc cgagcctaca tccttgccca caaggatgcc      240

atccagctct ggaggacgct catgggaccc accagagtgt tccgagcacg ccatgtggcc      300

ccagattcta tccgtgggag tttcggcctc actgacaccc gcaacaccac ccatggttcg      360

gactctgtgg tttcagccag cagagagatt gcagccttct tccctgactt cagtgaacag      420

cgctggtatg aggaggaaga gccccagttg cgctgtggcc ctgtgtgcta tagcccagag      480

ggaggtgtcc actatgtagc tggaacagga ggcctaggac cagcctga                   528


<210>  71
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 3

<400>  71

Met Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu 
1               5                   10                  15      


Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile 
            20                  25                  30          


Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe 
        35                  40                  45              


Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
    50                  55                  60                  


Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala 
65                  70                  75                  80  


Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala 
                85                  90                  95      


Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp 
            100                 105                 110         


Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg 
        115                 120                 125             


Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu 
    130                 135                 140                 


Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val Cys Tyr Ser Pro Glu 
145                 150                 155                 160 


Gly Gly Val His Tyr Val Ala Gly Thr Gly Gly Leu Gly Pro Ala 
                165                 170                 175 


<210>  72
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6 sequence optimized for E. coli expression

<400>  72
atgacgcaaa atctgggctc ggaaatggca agtatcctgc gctccccgca agcactgcaa       60

ctgaccctgg ctctgatcaa accggacgct gttgctcatc cgctgattct ggaagcggtc      120

caccagcaaa ttctgagcaa caaatttctg atcgtgcgta tgcgcgaact gctgtggcgt      180

aaagaagatt gccagcgttt ttatcgcgaa catgaaggcc gtttctttta tcaacgcctg      240

gttgaattca tggcctctgg tccgattcgc gcatatatcc tggctcacaa agatgcgatt      300

cagctgtggc gtaccctgat gggtccgacg cgcgtctttc gtgcacgtca tgtggcaccg      360

gactcaatcc gtggctcgtt cggtctgacc gatacgcgca ataccacgca cggtagcgac      420

tctgttgtta gtgcgtcccg tgaaatcgcg gcctttttcc cggacttctc cgaacagcgt      480

tggtacgaag aagaagaacc gcaactgcgc tgtggcccgg tctgttattc tccggaaggt      540

ggtgtccatt atgtggcggg cacgggtggt ctgggtccgg catga                      585


<210>  73
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 sequence optimized for E. coli expression

<400>  73

Met Thr Gln Asn Leu Gly Ser Glu Met Ala Ser Ile Leu Arg Ser Pro 
1               5                   10                  15      


Gln Ala Leu Gln Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala 
            20                  25                  30          


His Pro Leu Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys 
        35                  40                  45              


Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
    50                  55                  60                  


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His 
                85                  90                  95      


Lys Asp Ala Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val 
            100                 105                 110         


Phe Arg Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly 
        115                 120                 125             


Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser 
    130                 135                 140                 


Ala Ser Arg Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg 
145                 150                 155                 160 


Trp Tyr Glu Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val Cys Tyr 
                165                 170                 175     


Ser Pro Glu Gly Gly Val His Tyr Val Ala Gly Thr Gly Gly Leu Gly 
            180                 185                 190         


Pro Ala 
        


<210>  74
<211>  525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6 1 sequence optimized for E. coli expression

<400>  74
atgacgcaaa atctgggctc ggaaatggca agtatcctgc gctccccgca agcactgcaa       60

ctgaccctgg ctctgatcaa accggacgct gttgctcatc cgctgattct ggaagcggtc      120

caccagcaaa ttctgagcaa caaatttctg atcgtgcgta tgcgcgaact gctgtggcgt      180

aaagaagatt gccagcgttt ttatcgcgaa catgaaggcc gtttctttta tcaacgcctg      240

gttgaattca tggcctctgg tccgattcgc gcatatatcc tggctcacaa agatgcgatt      300

cagctgtggc gtaccctgat gggtccgacg cgcgtctttc gtgcacgtca tgtggcaccg      360

gactcaatcc gtggctcgtt cggtctgacc gatacgcgca ataccacgca cggtagcgac      420

tctgttgtta gtgcgtcccg tgaaatcgcg gcctttttcc cggacttctc cgaacagcgt      480

tggtacgaag aagaagaacc gcaactgcgc tgtggcccgg tctga                      525


<210>  75
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 1 sequence optimized for E. coli expression

<400>  75

Met Thr Gln Asn Leu Gly Ser Glu Met Ala Ser Ile Leu Arg Ser Pro 
1               5                   10                  15      


Gln Ala Leu Gln Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala 
            20                  25                  30          


His Pro Leu Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys 
        35                  40                  45              


Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
    50                  55                  60                  


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His 
                85                  90                  95      


Lys Asp Ala Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val 
            100                 105                 110         


Phe Arg Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly 
        115                 120                 125             


Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser 
    130                 135                 140                 


Ala Ser Arg Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg 
145                 150                 155                 160 


Trp Tyr Glu Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val 
                165                 170                 


<210>  76
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6 2 sequence optimized for E. coli expression

<400>  76
atgctgaccc tggctctgat caaaccggac gctgttgctc atccgctgat tctggaagcg       60

gtccaccagc aaattctgag caacaaattt ctgatcgtgc gtatgcgcga actgctgtgg      120

cgtaaagaag attgccagcg tttttatcgc gaacatgaag gccgtttctt ttatcaacgc      180

ctggttgaat tcatggcctc tggtccgatt cgcgcatata tcctggctca caaagatgcg      240

attcagctgt ggcgtaccct gatgggtccg acgcgcgtct ttcgtgcacg tcatgtggca      300

ccggactcaa tccgtggctc gttcggtctg accgatacgc gcaataccac gcacggtagc      360

gactctgttg ttagtgcgtc ccgtgaaatc gcggcctttt tcccggactt ctccgaacag      420

cgttggtacg aagaagaaga accgcaactg cgctgtggcc cggtctga                   468


<210>  77
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 2 sequence optimized for E. coli expression

<400>  77

Met Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu 
1               5                   10                  15      


Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile 
            20                  25                  30          


Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe 
        35                  40                  45              


Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
    50                  55                  60                  


Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala 
65                  70                  75                  80  


Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala 
                85                  90                  95      


Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp 
            100                 105                 110         


Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg 
        115                 120                 125             


Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu 
    130                 135                 140                 


Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val 
145                 150                 155 


<210>  78
<211>  528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME6 3 sequence optimized for E. coli expression

<400>  78
atgctgaccc tggctctgat caaaccggac gctgttgctc atccgctgat tctggaagcg       60

gtccaccagc aaattctgag caacaaattt ctgatcgtgc gtatgcgcga actgctgtgg      120

cgtaaagaag attgccagcg tttttatcgc gaacatgaag gccgtttctt ttatcaacgc      180

ctggttgaat tcatggcctc tggtccgatt cgcgcatata tcctggctca caaagatgcg      240

attcagctgt ggcgtaccct gatgggtccg acgcgcgtct ttcgtgcacg tcatgtggca      300

ccggactcaa tccgtggctc gttcggtctg accgatacgc gcaataccac gcacggtagc      360

gactctgttg ttagtgcgtc ccgtgaaatc gcggcctttt tcccggactt ctccgaacag      420

cgttggtacg aagaagaaga accgcaactg cgctgtggcc cggtctgtta ttctccggaa      480

ggtggtgtcc attatgtggc gggcacgggt ggtctgggtc cggcatga                   528


<210>  79
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 3 sequence optimized for E. coli expression

<400>  79

Met Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu 
1               5                   10                  15      


Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile 
            20                  25                  30          


Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe 
        35                  40                  45              


Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
    50                  55                  60                  


Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala 
65                  70                  75                  80  


Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala 
                85                  90                  95      


Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp 
            100                 105                 110         


Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg 
        115                 120                 125             


Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu 
    130                 135                 140                 


Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val Cys Tyr Ser Pro Glu 
145                 150                 155                 160 


Gly Gly Val His Tyr Val Ala Gly Thr Gly Gly Leu Gly Pro Ala 
                165                 170                 175 


<210>  80
<211>  1306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OriGene-NME7-1 full length

<400>  80
gacgttgtat acgactccta tagggcggcc gggaattcgt cgactggatc cggtaccgag       60

gagatctgcc gccgcgatcg ccatgaatca tagtgaaaga ttcgttttca ttgcagagtg      120

gtatgatcca aatgcttcac ttcttcgacg ttatgagctt ttattttacc caggggatgg      180

atctgttgaa atgcatgatg taaagaatca tcgcaccttt ttaaagcgga ccaaatatga      240

taacctgcac ttggaagatt tatttatagg caacaaagtg aatgtcttct ctcgacaact      300

ggtattaatt gactatgggg atcaatatac agctcgccag ctgggcagta ggaaagaaaa      360

aacgctagcc ctaattaaac cagatgcaat atcaaaggct ggagaaataa ttgaaataat      420

aaacaaagct ggatttacta taaccaaact caaaatgatg atgctttcaa ggaaagaagc      480

attggatttt catgtagatc accagtcaag accctttttc aatgagctga tccagtttat      540

tacaactggt cctattattg ccatggagat tttaagagat gatgctatat gtgaatggaa      600

aagactgctg ggacctgcaa actctggagt ggcacgcaca gatgcttctg aaagcattag      660

agccctcttt ggaacagatg gcataagaaa tgcagcgcat ggccctgatt cttttgcttc      720

tgcggccaga gaaatggagt tgttttttcc ttcaagtgga ggttgtgggc cggcaaacac      780

tgctaaattt actaattgta cctgttgcat tgttaaaccc catgctgtca gtgaaggact      840

gttgggaaag atcctgatgg ctatccgaga tgcaggtttt gaaatctcag ctatgcagat      900

gttcaatatg gatcgggtta atgttgagga attctatgaa gtttataaag gagtagtgac      960

cgaatatcat gacatggtga cagaaatgta ttctggccct tgtgtagcaa tggagattca     1020

acagaataat gctacaaaga catttcgaga attttgtgga cctgctgatc ctgaaattgc     1080

ccggcattta cgccctggaa ctctcagagc aatctttggt aaaactaaga tccagaatgc     1140

tgttcactgt actgatctgc cagaggatgg cctattagag gttcaatact tcttcaagat     1200

cttggataat acgcgtacgc ggccgctcga gcagaaactc atctcagaag aggatctggc     1260

agcaaatgat atcctggatt acaaggatga cgacgataag gtttaa                    1306


<210>  81
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OriGene-NME7-1 full length

<400>  81

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn Thr Arg Thr Arg Arg Leu Glu Gln 
    370                 375                 380                 


Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Asn Asp Ile Leu Asp Tyr 
385                 390                 395                 400 


Lys Asp Asp Asp Asp Lys Val 
                405         


<210>  82
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abnova NME7-1 Full length

<400>  82

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn 
    370                 375     


<210>  83
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abnova Partial NME7-B

<400>  83

Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr Lys Gly Val Val 
1               5                   10                  15      


Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser Gly Pro Cys Val 
            20                  25                  30          


Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe 
        35                  40                  45              


Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg Pro Gly Thr 
    50                  55                  60                  


Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Cys 
65                  70                  75                  80  


Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys 
                85                  90                  95      


Ile Leu 
        


<210>  84
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Histidine Tag

<400>  84
ctcgagcacc accaccacca ccactga                                           27


<210>  85
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Strept II Tag

<400>  85
accggttgga gccatcctca gttcgaaaag taatga                                 36


<210>  86
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-10 peptide

<400>  86

Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
1               5                   10                  15      


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
            20                  25                  30          


Ser Gly Ala 
        35  


<210>  87
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-10 peptide

<400>  87

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val 
        35  


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  88

Leu Ala Leu Ile Lys Pro Asp Ala 
1               5               


<210>  89
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  89

Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His 
1               5                   10                  15      


Gln Ser 
        


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  90

Ala Leu Asp Phe His Val Asp His Gln Ser 
1               5                   10  


<210>  91
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  91

Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu 
1               5                   10                  


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  92

Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro 
1               5                   10          


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  93

Arg Asp Asp Ala Ile Cys Glu Trp 
1               5               


<210>  94
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  94

Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe 
1               5                   10                  15      


Gly Thr Asp Gly Ile Arg Asn Ala Ala 
            20                  25  


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  95

Glu Leu Phe Phe Pro Ser Ser Gly Gly 
1               5                   


<210>  96
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  96

Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
1               5                   10                  15      


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala 
            20                  25      


<210>  97
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  97

Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln Met 
1               5                   10                  15      


Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr Lys 
            20                  25                  30          


Gly Val Val Thr 
        35      


<210>  98
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  98

Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp 
1               5                   10                  15  


<210>  99
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  99

Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly 
1               5                   10                  15      


Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg 
            20                  25                  30          


Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala 
        35                  40              


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  100

Tyr Ser Gly Pro Cys Val Ala Met 
1               5               


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  101

Phe Arg Glu Phe Cys Gly Pro 
1               5           


<210>  102
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  102

Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr 
1               5                   10                  15      


Phe Phe Lys Ile Leu Asp Asn 
            20              


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  103

Ile Gln Asn Ala Val His Cys Thr Asp 
1               5                   


<210>  104
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  104

Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys 
1               5                   10                  15      


Ile Leu Asp Asn 
            20  


<210>  105
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  105

Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys 
1               5                   10              


<210>  106
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  106

Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
1               5                   10          


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  107

Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser 
1               5                   10                  15      


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  108

Asn Glu Leu Ile Gln Phe Ile Thr Thr 
1               5                   


<210>  109
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  109

Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu 
1               5                   10                  


<210>  110
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  110

Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe 
1               5                   10                  15      


Gly Thr Asp Gly Ile 
            20      


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  111

Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser 
1               5                   10      


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  112

Ala Leu Phe Gly Thr Asp Gly Ile 
1               5               


<210>  113
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  113

Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu 
1               5                   10                  


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  114

Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala 
1               5                   10      


<210>  115
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  115

Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
1               5                   10                  15      


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  116

Glu Val Tyr Lys Gly Val Val Thr 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  117

Glu Tyr His Asp Met Val Thr Glu 
1               5               


<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  118

Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg 
1               5                   10                  15  


<210>  119
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  119

Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val 
1               5                   10          


<210>  120
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  120

Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu 
1               5                   10                  15      


Asp Asn 
        


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide of NME7AB

<400>  121

Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe 
1               5                   10                  15      


Pro 
    


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  122

Ile Cys Glu Trp Lys Arg Leu 
1               5           


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  123

Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala 
1               5                   10      


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  124

His Ala Val Ser Glu Gly Leu Leu Gly Lys 
1               5                   10  


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  125

Val Thr Glu Met Tyr Ser Gly Pro 
1               5               


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  126

Asn Ala Thr Lys Thr Phe Arg Glu Phe 
1               5                   


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  127

Ala Ile Arg Asp Ala Gly Phe Glu Ile 
1               5                   


<210>  128
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  128

Ala Ile Cys Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn 
1               5                   10              


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  129

Asp His Gln Ser Arg Pro Phe Phe 
1               5               


<210>  130
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  130

Ala Ile Cys Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn 
1               5                   10              


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  131

Val Asp His Gln Ser Arg Pro Phe 
1               5               


<210>  132
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  132

Pro Asp Ser Phe Ala Ser 
1               5       


<210>  133
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME7

<400>  133

Lys Ala Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile 
1               5                   10                  15      


Thr Lys 
        


<210>  134
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME1

<400>  134

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu 
            20                  25                  


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME1

<400>  135

Val Asp Leu Lys Asp Arg Pro Phe 
1               5               


<210>  136
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME1

<400>  136

His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys Glu Ile Gly Leu Trp 
1               5                   10                  15      


Phe 
    


<210>  137
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME1

<400>  137

Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu 
1               5                   10                  15      


Val Gly Glu Ile Ile Lys Arg Phe Glu 
            20                  25  


<210>  138
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME1

<400>  138

Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met 
1               5                   10                  15      


His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly Leu Asn 
            20                  25                  30  


<210>  139
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME1

<400>  139

Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys Glu Ile 
1               5                   10                  15      


Gly Leu Trp Phe His Pro Glu Glu Leu Val 
            20                  25      


<210>  140
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunizing peptides derived from human NME1

<400>  140

Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu Ile Ile 
1               5                   10                  


<210>  141
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A peptide 1 (A domain)

<400>  141

Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser 
1               5                   10                  15      


<210>  142
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A peptide 2 (A domain)

<400>  142

Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser 
1               5                   10      


<210>  143
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B peptide 1 (B domain)

<400>  143

Asp Ala Gly Phe Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg 
1               5                   10                  15      


Val Asn Val Glu 
            20  


<210>  144
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B peptide 2 (B domain)

<400>  144

Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
1               5                   10                  15      


<210>  145
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B peptide 3 (B domain)

<400>  145

Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp 
1               5                   10                  15      


Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe 
            20                  25                  


<210>  146
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7 a

<400>  146
atgaatcata gtgaaagatt cgttttcatt gcagagtggt atgatccaaa tgcttcactt       60

cttcgacgtt atgagctttt attttaccca ggggatggat ctgttgaaat gcatgatgta      120

aagaatcatc gcaccttttt aaagcggacc aaatatgata acctgcactt ggaagattta      180

tttataggca acaaagtgaa tgtcttttct cgacaactgg tattaattga ctatggggat      240

caatatacag ctcgccagct gggcagtagg aaagaaaaaa cgctagccct aattaaacca      300

gatgcaatat caaaggctgg agaaataatt gaaataataa acaaagctgg atttactata      360

accaaactca aaatgatgat gctttcaagg aaagaagcat tggattttca tgtagatcac      420

cagtcaagac cctttttcaa tgagctgatc cagtttatta caactggtcc tattattgcc      480

atggagattt taagagatga tgctatatgt gaatggaaaa gactgctggg acctgcaaac      540

tctggagtgg cacgcacaga tgcttctgaa agcattagag ccctctttgg aacagatggc      600

ataagaaatg cagcgcatgg ccctgattct tttgcttctg cggccagaga aatggagttg      660

ttttttcctt caagtggagg ttgtgggccg gcaaacactg ctaaatttac taattgtacc      720

tgttgcattg ttaaacccca tgctgtcagt gaaggactgt tgggaaagat cctgatggct      780

atccgagatg caggttttga aatctcagct atgcagatgt tcaatatgga tcgggttaat      840

gttgaggaat tctatgaagt ttataaagga gtagtgaccg aatatcatga catggtgaca      900

gaaatgtatt ctggcccttg tgtagcaatg gagattcaac agaataatgc tacaaagaca      960

tttcgagaat tttgtggacc tgctgatcct gaaattgccc ggcatttacg ccctggaact     1020

ctcagagcaa tctttggtaa aactaagatc cagaatgctg ttcactgtac tgatctgcca     1080

gaggatggcc tattagaggt tcaatacttc ttcaagatct tggataatta g              1131


<210>  147
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7 a

<400>  147

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn 
    370                 375     


<210>  148
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7 b

<400>  148
atgcatgatg taaagaatca tcgcaccttt ttaaagcgga ccaaatatga taacctgcac       60

ttggaagatt tatttatagg caacaaagtg aatgtctttt ctcgacaact ggtattaatt      120

gactatgggg atcaatatac agctcgccag ctgggcagta ggaaagaaaa aacgctagcc      180

ctaattaaac cagatgcaat atcaaaggct ggagaaataa ttgaaataat aaacaaagct      240

ggatttacta taaccaaact caaaatgatg atgctttcaa ggaaagaagc attggatttt      300

catgtagatc accagtcaag accctttttc aatgagctga tccagtttat tacaactggt      360

cctattattg ccatggagat tttaagagat gatgctatat gtgaatggaa aagactgctg      420

ggacctgcaa actctggagt ggcacgcaca gatgcttctg aaagcattag agccctcttt      480

ggaacagatg gcataagaaa tgcagcgcat ggccctgatt cttttgcttc tgcggccaga      540

gaaatggagt tgttttttcc ttcaagtgga ggttgtgggc cggcaaacac tgctaaattt      600

actaattgta cctgttgcat tgttaaaccc catgctgtca gtgaaggact gttgggaaag      660

atcctgatgg ctatccgaga tgcaggtttt gaaatctcag ctatgcagat gttcaatatg      720

gatcgggtta atgttgagga attctatgaa gtttataaag gagtagtgac cgaatatcat      780

gacatggtga cagaaatgta ttctggccct tgtgtagcaa tggagattca acagaataat      840

gctacaaaga catttcgaga attttgtgga cctgctgatc ctgaaattgc ccggcattta      900

cgccctggaa ctctcagagc aatctttggt aaaactaaga tccagaatgc tgttcactgt      960

actgatctgc cagaggatgg cctattagag gttcaatact tcttcaagat cttggataat     1020

tag                                                                   1023


<210>  149
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7 b

<400>  149

Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys Arg Thr Lys Tyr 
1               5                   10                  15      


Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn Lys Val Asn Val 
            20                  25                  30          


Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp Gln Tyr Thr Ala 
        35                  40                  45              


Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala Leu Ile Lys Pro 
    50                  55                  60                  


Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala 
65                  70                  75                  80  


Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu Ser Arg Lys Glu 
                85                  90                  95      


Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro Phe Phe Asn Glu 
            100                 105                 110         


Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala Met Glu Ile Leu 
        115                 120                 125             


Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn 
    130                 135                 140                 


Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe 
145                 150                 155                 160 


Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro Asp Ser Phe Ala 
                165                 170                 175     


Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys 
            180                 185                 190         


Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr Cys Cys Ile Val 
        195                 200                 205             


Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys Ile Leu Met Ala 
    210                 215                 220                 


Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln Met Phe Asn Met 
225                 230                 235                 240 


Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr Lys Gly Val Val 
                245                 250                 255     


Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser Gly Pro Cys Val 
            260                 265                 270         


Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe 
        275                 280                 285             


Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg Pro Gly Thr 
    290                 295                 300                 


Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Cys 
305                 310                 315                 320 


Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys 
                325                 330                 335     


Ile Leu Asp Asn 
            340 


<210>  150
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB also known as NME7AB

<400>  150
atggaaaaaa cgctagccct aattaaacca gatgcaatat caaaggctgg agaaataatt       60

gaaataataa acaaagctgg atttactata accaaactca aaatgatgat gctttcaagg      120

aaagaagcat tggattttca tgtagatcac cagtcaagac cctttttcaa tgagctgatc      180

cagtttatta caactggtcc tattattgcc atggagattt taagagatga tgctatatgt      240

gaatggaaaa gactgctggg acctgcaaac tctggagtgg cacgcacaga tgcttctgaa      300

agcattagag ccctctttgg aacagatggc ataagaaatg cagcgcatgg ccctgattct      360

tttgcttctg cggccagaga aatggagttg ttttttcctt caagtggagg ttgtgggccg      420

gcaaacactg ctaaatttac taattgtacc tgttgcattg ttaaacccca tgctgtcagt      480

gaaggactgt tgggaaagat cctgatggct atccgagatg caggttttga aatctcagct      540

atgcagatgt tcaatatgga tcgggttaat gttgaggaat tctatgaagt ttataaagga      600

gtagtgaccg aatatcatga catggtgaca gaaatgtatt ctggcccttg tgtagcaatg      660

gagattcaac agaataatgc tacaaagaca tttcgagaat tttgtggacc tgctgatcct      720

gaaattgccc ggcatttacg ccctggaact ctcagagcaa tctttggtaa aactaagatc      780

cagaatgctg ttcactgtac tgatctgcca gaggatggcc tattagaggt tcaatacttc      840

ttcaagatct tggataatta g                                                861


<210>  151
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB also known as NME7AB

<400>  151

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
        275                 280                 285     


<210>  152
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-X1

<400>  152
atgatgatgc tttcaaggaa agaagcattg gattttcatg tagatcacca gtcaagaccc       60

tttttcaatg agctgatcca gtttattaca actggtccta ttattgccat ggagatttta      120

agagatgatg ctatatgtga atggaaaaga ctgctgggac ctgcaaactc tggagtggca      180

cgcacagatg cttctgaaag cattagagcc ctctttggaa cagatggcat aagaaatgca      240

gcgcatggcc ctgattcttt tgcttctgcg gccagagaaa tggagttgtt ttttccttca      300

agtggaggtt gtgggccggc aaacactgct aaatttacta attgtacctg ttgcattgtt      360

aaaccccatg ctgtcagtga aggactgttg ggaaagatcc tgatggctat ccgagatgca      420

ggttttgaaa tctcagctat gcagatgttc aatatggatc gggttaatgt tgaggaattc      480

tatgaagttt ataaaggagt agtgaccgaa tatcatgaca tggtgacaga aatgtattct      540

ggcccttgtg tagcaatgga gattcaacag aataatgcta caaagacatt tcgagaattt      600

tgtggacctg ctgatcctga aattgcccgg catttacgcc ctggaactct cagagcaatc      660

tttggtaaaa ctaagatcca gaatgctgtt cactgtactg atctgccaga ggatggccta      720

ttagaggttc aatacttctt caagatcttg gataattag                             759


<210>  153
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-X1

<400>  153

Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His 
1               5                   10                  15      


Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly 
            20                  25                  30          


Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp 
        35                  40                  45              


Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala 
    50                  55                  60                  


Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala 
65                  70                  75                  80  


Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu 
                85                  90                  95      


Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe 
            100                 105                 110         


Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
        115                 120                 125             


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
    130                 135                 140                 


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
145                 150                 155                 160 


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
                165                 170                 175     


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
            180                 185                 190         


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
        195                 200                 205             


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
    210                 215                 220                 


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
225                 230                 235                 240 


Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
                245                 250         


<210>  154
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7 a (optimized for E coli expression)

<400>  154
atgaatcact ccgaacgctt tgtttttatc gccgaatggt atgacccgaa tgcttccctg       60

ctgcgccgct acgaactgct gttttatccg ggcgatggta gcgtggaaat gcatgacgtt      120

aaaaatcacc gtacctttct gaaacgcacg aaatatgata atctgcatct ggaagacctg      180

tttattggca acaaagtcaa tgtgttctct cgtcagctgg tgctgatcga ttatggcgac      240

cagtacaccg cgcgtcaact gggtagtcgc aaagaaaaaa cgctggccct gattaaaccg      300

gatgcaatct ccaaagctgg cgaaattatc gaaattatca acaaagcggg tttcaccatc      360

acgaaactga aaatgatgat gctgagccgt aaagaagccc tggattttca tgtcgaccac      420

cagtctcgcc cgtttttcaa tgaactgatt caattcatca ccacgggtcc gattatcgca      480

atggaaattc tgcgtgatga cgctatctgc gaatggaaac gcctgctggg cccggcaaac      540

tcaggtgttg cgcgtaccga tgccagtgaa tccattcgcg ctctgtttgg caccgatggt      600

atccgtaatg cagcacatgg tccggactca ttcgcatcgg cagctcgtga aatggaactg      660

tttttcccga gctctggcgg ttgcggtccg gcaaacaccg ccaaatttac caattgtacg      720

tgctgtattg tcaaaccgca cgcagtgtca gaaggcctgc tgggtaaaat tctgatggca      780

atccgtgatg ctggctttga aatctcggcc atgcagatgt tcaacatgga ccgcgttaac      840

gtcgaagaat tctacgaagt ttacaaaggc gtggttaccg aatatcacga tatggttacg      900

gaaatgtact ccggtccgtg cgtcgcgatg gaaattcagc aaaacaatgc caccaaaacg      960

tttcgtgaat tctgtggtcc ggcagatccg gaaatcgcac gtcatctgcg tccgggtacc     1020

ctgcgcgcaa tttttggtaa aacgaaaatc cagaacgctg tgcactgtac cgatctgccg     1080

gaagacggtc tgctggaagt tcaatacttt ttcaaaattc tggataat                  1128


<210>  155
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7 a (optimized for E coli expression)

<400>  155

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn Thr Gly 
    370                 375             


<210>  156
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7 b (optimized for E coli expression)

<400>  156
atgcatgacg ttaaaaatca ccgtaccttt ctgaaacgca cgaaatatga taatctgcat       60

ctggaagacc tgtttattgg caacaaagtc aatgtgttct ctcgtcagct ggtgctgatc      120

gattatggcg accagtacac cgcgcgtcaa ctgggtagtc gcaaagaaaa aacgctggcc      180

ctgattaaac cggatgcaat ctccaaagct ggcgaaatta tcgaaattat caacaaagcg      240

ggtttcacca tcacgaaact gaaaatgatg atgctgagcc gtaaagaagc cctggatttt      300

catgtcgacc accagtctcg cccgtttttc aatgaactga ttcaattcat caccacgggt      360

ccgattatcg caatggaaat tctgcgtgat gacgctatct gcgaatggaa acgcctgctg      420

ggcccggcaa actcaggtgt tgcgcgtacc gatgccagtg aatccattcg cgctctgttt      480

ggcaccgatg gtatccgtaa tgcagcacat ggtccggact cattcgcatc ggcagctcgt      540

gaaatggaac tgtttttccc gagctctggc ggttgcggtc cggcaaacac cgccaaattt      600

accaattgta cgtgctgtat tgtcaaaccg cacgcagtgt cagaaggcct gctgggtaaa      660

attctgatgg caatccgtga tgctggcttt gaaatctcgg ccatgcagat gttcaacatg      720

gaccgcgtta acgtcgaaga attctacgaa gtttacaaag gcgtggttac cgaatatcac      780

gatatggtta cggaaatgta ctccggtccg tgcgtcgcga tggaaattca gcaaaacaat      840

gccaccaaaa cgtttcgtga attctgtggt ccggcagatc cggaaatcgc acgtcatctg      900

cgtccgggta ccctgcgcgc aatttttggt aaaacgaaaa tccagaacgc tgtgcactgt      960

accgatctgc cggaagacgg tctgctggaa gttcaatact ttttcaaaat tctggataat     1020


<210>  157
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7 b (optimized for E coli expression)

<400>  157

Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys Arg Thr Lys Tyr 
1               5                   10                  15      


Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn Lys Val Asn Val 
            20                  25                  30          


Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp Gln Tyr Thr Ala 
        35                  40                  45              


Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala Leu Ile Lys Pro 
    50                  55                  60                  


Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala 
65                  70                  75                  80  


Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu Ser Arg Lys Glu 
                85                  90                  95      


Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro Phe Phe Asn Glu 
            100                 105                 110         


Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala Met Glu Ile Leu 
        115                 120                 125             


Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn 
    130                 135                 140                 


Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe 
145                 150                 155                 160 


Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro Asp Ser Phe Ala 
                165                 170                 175     


Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys 
            180                 185                 190         


Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr Cys Cys Ile Val 
        195                 200                 205             


Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys Ile Leu Met Ala 
    210                 215                 220                 


Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln Met Phe Asn Met 
225                 230                 235                 240 


Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr Lys Gly Val Val 
                245                 250                 255     


Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser Gly Pro Cys Val 
            260                 265                 270         


Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe 
        275                 280                 285             


Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg Pro Gly Thr 
    290                 295                 300                 


Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Cys 
305                 310                 315                 320 


Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys 
                325                 330                 335     


Ile Leu Asp Asn Thr Gly 
            340         


<210>  158
<211>  858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB also known as NME7AB (optimized for E coli 
       expression)

<400>  158
atggaaaaaa cgctggccct gattaaaccg gatgcaatct ccaaagctgg cgaaattatc       60

gaaattatca acaaagcggg tttcaccatc acgaaactga aaatgatgat gctgagccgt      120

aaagaagccc tggattttca tgtcgaccac cagtctcgcc cgtttttcaa tgaactgatt      180

caattcatca ccacgggtcc gattatcgca atggaaattc tgcgtgatga cgctatctgc      240

gaatggaaac gcctgctggg cccggcaaac tcaggtgttg cgcgtaccga tgccagtgaa      300

tccattcgcg ctctgtttgg caccgatggt atccgtaatg cagcacatgg tccggactca      360

ttcgcatcgg cagctcgtga aatggaactg tttttcccga gctctggcgg ttgcggtccg      420

gcaaacaccg ccaaatttac caattgtacg tgctgtattg tcaaaccgca cgcagtgtca      480

gaaggcctgc tgggtaaaat tctgatggca atccgtgatg ctggctttga aatctcggcc      540

atgcagatgt tcaacatgga ccgcgttaac gtcgaagaat tctacgaagt ttacaaaggc      600

gtggttaccg aatatcacga tatggttacg gaaatgtact ccggtccgtg cgtcgcgatg      660

gaaattcagc aaaacaatgc caccaaaacg tttcgtgaat tctgtggtcc ggcagatccg      720

gaaatcgcac gtcatctgcg tccgggtacc ctgcgcgcaa tttttggtaa aacgaaaatc      780

cagaacgctg tgcactgtac cgatctgccg gaagacggtc tgctggaagt tcaatacttt      840

ttcaaaattc tggataat                                                    858


<210>  159
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB also known as NME7AB (optimized for E coli 
       expression)

<400>  159

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn Thr Gly 
        275                 280                 285             


<210>  160
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7-X1 (optimized for E coli expression)

<400>  160
atgatgatgc tgagccgtaa agaagccctg gattttcatg tcgaccacca gtctcgcccg       60

tttttcaatg aactgattca attcatcacc acgggtccga ttatcgcaat ggaaattctg      120

cgtgatgacg ctatctgcga atggaaacgc ctgctgggcc cggcaaactc aggtgttgcg      180

cgtaccgatg ccagtgaatc cattcgcgct ctgtttggca ccgatggtat ccgtaatgca      240

gcacatggtc cggactcatt cgcatcggca gctcgtgaaa tggaactgtt tttcccgagc      300

tctggcggtt gcggtccggc aaacaccgcc aaatttacca attgtacgtg ctgtattgtc      360

aaaccgcacg cagtgtcaga aggcctgctg ggtaaaattc tgatggcaat ccgtgatgct      420

ggctttgaaa tctcggccat gcagatgttc aacatggacc gcgttaacgt cgaagaattc      480

tacgaagttt acaaaggcgt ggttaccgaa tatcacgata tggttacgga aatgtactcc      540

ggtccgtgcg tcgcgatgga aattcagcaa aacaatgcca ccaaaacgtt tcgtgaattc      600

tgtggtccgg cagatccgga aatcgcacgt catctgcgtc cgggtaccct gcgcgcaatt      660

tttggtaaaa cgaaaatcca gaacgctgtg cactgtaccg atctgccgga agacggtctg      720

ctggaagttc aatacttttt caaaattctg gataat                                756


<210>  161
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-X1 (optimized for E coli expression)

<400>  161

Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His 
1               5                   10                  15      


Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly 
            20                  25                  30          


Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp 
        35                  40                  45              


Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala 
    50                  55                  60                  


Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala 
65                  70                  75                  80  


Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu 
                85                  90                  95      


Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe 
            100                 105                 110         


Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
        115                 120                 125             


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
    130                 135                 140                 


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
145                 150                 155                 160 


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
                165                 170                 175     


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
            180                 185                 190         


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
        195                 200                 205             


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
    210                 215                 220                 


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
225                 230                 235                 240 


Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn Thr Gly 
                245                 250                 


<210>  162
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DM10 domain of NME7

<400>  162

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys 
                85                  90      


<210>  163
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment or variation of PSMGFR peptide

<400>  163

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
1               5                   10                  15      


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
            20                  25                  30          


Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
        35                  40              


<210>  164
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment or variation of PSMGFR peptide

<400>  164

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr 
        35  


<210>  165
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment or variation of PSMGFR peptide

<400>  165

Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 
1               5                   10                  15      


Val Glu Thr Gln Phe Asn Gln Tyr 
            20                  


<210>  166
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment or variation of PSMGFR peptide

<400>  166

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
1               5                   10                  15      


Ala Phe Arg Glu Gly Thr Ile Asn 
            20                  


<210>  167
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment or variation of PSMGFR peptide

<400>  167

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
1               5                   10                  15      


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
            20                  25                  30          


Asn Gln Tyr Lys Thr Glu 
        35              


<210>  168
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment or variation of PSMGFR peptide

<400>  168

Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 
1               5                   10                  15      


Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
            20                  25                  30          


Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45  


<210>  169
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser of NME7B peptide 3 (B domain)

<400>  169

Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Ser Thr Asp 
1               5                   10                  15      


Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe 
            20                  25                  


<210>  170
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-10 peptide

<400>  170

Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
1               5                   10                  15      


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
            20                  25                  30          


Ser Gly Ala 
        35  


<210>  171
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-10 peptide

<400>  171

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val 
        35  


<210>  172
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F9A5A1H heavy chain

<400>  172

Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly 
            20                  25                  30          


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
        35                  40                  45              


Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe Lys 
    50                  55                  60                  


Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ser Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Leu Arg Gly Ile Arg Pro Gly Pro Leu Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  173
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F9A4A3H heavy chain

<400>  173

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Leu Tyr Val Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  174
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9E2B11H

<400>  174

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr 
        115     


<210>  175
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9E10E4H

<400>  175

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  176
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9G2C4H

<400>  176

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  177
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F3A5D4H

<400>  177

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  178
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H5H5G4H

<400>  178

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  179
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F9A4A3H

<400>  179

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Leu Tyr Val Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  180
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9E2B11H

<400>  180

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr 
        115     


<210>  181
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9E10E4H

<400>  181

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  182
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9G2C4H

<400>  182

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  183
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F3A5D4H

<400>  183

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  184
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H5H5G4H

<400>  184

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  185
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F9A4A3L

<400>  185

Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Met Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  186
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9E2B11L

<400>  186

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  187
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9E10E4L

<400>  187

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  188
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9G2C4L

<400>  188

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  189
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F3A5D4L

<400>  189

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  190
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H5H5G4L

<400>  190

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  191
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F9A5A1L

<400>  191

Glu Ile Leu Leu Thr Gln Ser Pro Ala Ile Ile Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ile Trp Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Phe Ser Phe Thr Ile Asn Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  192
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9E2B11L

<400>  192

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  193
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9E10E4L

<400>  193

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  194
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D9G2C4L

<400>  194

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  195
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F3A5D4L

<400>  195

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  196
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H5H5G4L

<400>  196

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  197
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F9A4A3L

<400>  197

Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Met Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  198
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F9A5A1L

<400>  198

Glu Ile Leu Leu Thr Gln Ser Pro Ala Ile Ile Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ile Trp Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Phe Ser Phe Thr Ile Asn Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  199
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  199

Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly 
1               5                   10                  15      


Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu 
            20                  25                  30          


Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp 
        35                  40                  45              


His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr 
    50                  55                  60                  


Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu 
65                  70                  75                  80  


Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp 
                85                  90                  95      


Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn 
            100                 105                 110         


Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu 
        115                 120                 125             


Leu Phe Phe 
    130     


<210>  200
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2 partial sequence

<400>  200

Met Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu 
        35                  40                  45              


Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Ser Leu Trp Phe Lys Pro Glu Glu Leu Val Asp Tyr Lys Ser 
    130                 135                 140                 


Cys Ala His Asp Trp Val Tyr Glu 
145                 150         


<210>  201
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B partial sequence

<400>  201

Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
1               5                   10                  15      


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
            20                  25                  30          


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
        35                  40                  45              


Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
    50                  55                  60                  


Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala 
65                  70                  75                  80  


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
                85                  90                  95      


Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
            100                 105                 110         


Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
        115                 120                 125             


Glu Val Gln Tyr Phe Phe 
    130                 


<210>  202
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2 partial sequence

<400>  202

Met Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu 
        35                  40                  45              


Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Ser Leu Trp Phe Lys Pro Glu Glu Leu Val Asp Tyr Lys Ser 
    130                 135                 140                 


Cys Ala His Asp Trp Val Tyr Glu 
145                 150         


<210>  203
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  203

Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly 
1               5                   10                  15      


Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu 
            20                  25                  30          


Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp 
        35                  40                  45              


His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr 
    50                  55                  60                  


Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu 
65                  70                  75                  80  


Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp 
                85                  90                  95      


Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn 
            100                 105                 110         


Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu 
        115                 120                 125             


Leu Phe Phe 
    130     


<210>  204
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3 partial sequence

<400>  204

Glu Arg Thr Phe Leu Ala Val Lys Pro Asp Gly Val Gln Arg Arg Leu 
1               5                   10                  15      


Val Gly Glu Ile Val Arg Arg Phe Glu Arg Lys Gly Phe Lys Leu Val 
            20                  25                  30          


Ala Leu Lys Leu Val Gln Ala Ser Glu Glu Leu Leu Arg Glu His Tyr 
        35                  40                  45              


Val Glu Leu Arg Glu Arg Pro Phe Tyr Ser Arg Leu Val Lys Tyr Met 
    50                  55                  60                  


Gly Ser Gly Pro Val Val Ala Met Val Trp Gln Gly Leu Asp Val Val 
65                  70                  75                  80  


Arg Ala Ser Arg Ala Leu Ile Gly Ala Thr Asp Pro Gly Asp Ala Thr 
                85                  90                  95      


Pro Gly Thr Ile Arg Gly Asp Phe Cys Val Glu Val Gly Lys Asn Val 
            100                 105                 110         


Ile His Gly Ser Asp Ser Val Glu Ser Ala Gln Arg Glu Ile Ala Leu 
        115                 120                 125             


Trp Phe 
    130 


<210>  205
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B partial sequence

<400>  205

Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
1               5                   10                  15      


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
            20                  25                  30          


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
        35                  40                  45              


Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
    50                  55                  60                  


Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala 
65                  70                  75                  80  


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
                85                  90                  95      


Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
            100                 105                 110         


Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
        115                 120                 125             


Glu Val Gln Tyr Phe Phe 
    130                 


<210>  206
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3 partial sequence

<400>  206

Met Ile Cys Leu Val Leu Thr Ile Phe Ala Asn Leu Phe Pro Ser Ala 
1               5                   10                  15      


Tyr Ser Gly Val Asn Glu Arg Thr Phe Leu Ala Val Lys Pro Asp Gly 
            20                  25                  30          


Val Gln Arg Arg Leu Val Gly Glu Ile Val Arg Arg Phe Glu Arg Lys 
        35                  40                  45              


Gly Phe Lys Leu Val Ala Leu Lys Leu Val Gln Ala Ser Glu Glu Leu 
    50                  55                  60                  


Leu Arg Glu His Tyr Val Glu Leu Arg Glu Arg Pro Phe Tyr Ser Arg 
65                  70                  75                  80  


Leu Val Lys Tyr Met Gly Ser Gly Pro Val Val Ala Met Val Trp Gln 
                85                  90                  95      


Gly Leu Asp Val Val Arg Ala Ser Arg Ala Leu Ile Gly Ala Thr Asp 
            100                 105                 110         


Pro Gly Asp Ala Thr Pro Gly Thr Ile Arg Gly Asp Phe Cys Val Glu 
        115                 120                 125             


Val Gly Lys Asn Val Ile His Gly Ser Asp Ser Val Glu Ser Ala Gln 
    130                 135                 140                 


Arg Glu Ile Ala Leu Trp Phe Arg Glu Asp Glu Leu Leu Cys Trp Glu 
145                 150                 155                 160 


Asp Ser Ala Gly His Trp Leu Tyr Glu 
                165                 


<210>  207
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  207

Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly 
1               5                   10                  15      


Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu 
            20                  25                  30          


Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp 
        35                  40                  45              


His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr 
    50                  55                  60                  


Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu 
65                  70                  75                  80  


Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp 
                85                  90                  95      


Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn 
            100                 105                 110         


Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu 
        115                 120                 125             


Leu Phe Phe 
    130     


<210>  208
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4 partial sequence

<400>  208

Glu Arg Thr Leu Val Ala Val Lys Pro Asp Gly Val Gln Arg Arg Leu 
1               5                   10                  15      


Val Gly Asp Val Ile Gln Arg Phe Glu Arg Arg Gly Phe Thr Leu Val 
            20                  25                  30          


Gly Met Lys Met Leu Gln Ala Pro Glu Ser Val Leu Ala Glu His Tyr 
        35                  40                  45              


Gln Asp Leu Arg Arg Lys Pro Phe Tyr Pro Ala Leu Ile Arg Tyr Met 
    50                  55                  60                  


Ser Ser Gly Pro Val Val Ala Met Val Trp Glu Gly Tyr Asn Val Val 
65                  70                  75                  80  


Arg Ala Ser Arg Ala Met Ile Gly His Thr Asp Ser Ala Glu Ala Ala 
                85                  90                  95      


Pro Gly Thr Ile Arg Gly Asp Phe Ser Val His Ile Ser Arg Asn Val 
            100                 105                 110         


Ile His Ala Ser Asp Ser Val Glu Gly Ala Gln Arg Glu Ile Gln Leu 
        115                 120                 125             


Trp Phe 
    130 


<210>  209
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B partial sequence

<400>  209

Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly 
1               5                   10                  15      


Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met 
            20                  25                  30          


Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val 
        35                  40                  45              


Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr 
    50                  55                  60                  


Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys 
65                  70                  75                  80  


Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His 
                85                  90                  95      


Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln 
            100                 105                 110         


Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val 
        115                 120                 125             


Gln Tyr Phe Phe 
    130         


<210>  210
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4 partial sequence

<400>  210

Thr Leu Val Ala Val Lys Pro Asp Gly Val Gln Arg Arg Leu Val Gly 
1               5                   10                  15      


Asp Val Ile Gln Arg Phe Glu Arg Arg Gly Phe Thr Leu Val Gly Met 
            20                  25                  30          


Lys Met Leu Gln Ala Pro Glu Ser Val Leu Ala Glu His Tyr Gln Asp 
        35                  40                  45              


Leu Arg Arg Lys Pro Phe Tyr Pro Ala Leu Ile Arg Tyr Met Ser Ser 
    50                  55                  60                  


Gly Pro Val Val Ala Met Val Trp Glu Gly Tyr Asn Val Val Arg Ala 
65                  70                  75                  80  


Ser Arg Ala Met Ile Gly His Thr Asp Ser Ala Glu Ala Ala Pro Gly 
                85                  90                  95      


Thr Ile Arg Gly Asp Phe Ser Val His Ile Ser Arg Asn Val Ile His 
            100                 105                 110         


Ala Ser Asp Ser Val Glu Gly Ala Gln Arg Glu Ile Gln Leu Trp Phe 
        115                 120                 125             


<210>  211
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  211

Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly 
1               5                   10                  15      


Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu 
            20                  25                  30          


Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp 
        35                  40                  45              


His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr 
    50                  55                  60                  


Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu 
65                  70                  75                  80  


Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp 
                85                  90                  95      


Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn 
            100                 105                 110         


Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu 
        115                 120                 125             


Leu Phe Phe 
    130     


<210>  212
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5 partial sequence

<400>  212

Glu Lys Thr Leu Ala Ile Ile Lys Pro Asp Ile Val Asp Lys Glu Glu 
1               5                   10                  15      


Glu Ile Gln Asp Ile Ile Leu Arg Ser Gly Phe Thr Ile Val Gln Arg 
            20                  25                  30          


Arg Lys Leu Arg Leu Ser Pro Glu Gln Cys Ser Asn Phe Tyr Val Glu 
        35                  40                  45              


Lys Tyr Gly Lys Met Phe Phe Pro Asn Leu Thr Ala Tyr Met Ser Ser 
    50                  55                  60                  


Gly Pro Leu Val Ala Met Ile Leu Ala Arg His Lys Ala Ile Ser Tyr 
65                  70                  75                  80  


Trp Leu Glu Leu Leu Gly Pro Asn Asn Ser Leu Val Ala Lys Glu Thr 
                85                  90                  95      


His Pro Asp Ser Leu Arg Ala Ile Tyr Gly Thr Asp Asp Leu Arg Asn 
            100                 105                 110         


Ala Leu His Gly Ser Asn Asp Phe Ala Ala Ala Glu Arg Glu Ile Arg 
        115                 120                 125             


Phe Met Phe 
    130     


<210>  213
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B partial sequence

<400>  213

Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly 
1               5                   10                  15      


Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met 
            20                  25                  30          


Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val 
        35                  40                  45              


Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr 
    50                  55                  60                  


Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys 
65                  70                  75                  80  


Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His 
                85                  90                  95      


Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln 
            100                 105                 110         


Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val 
        115                 120                 125             


Gln Tyr Phe Phe 
    130         


<210>  214
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5 partial sequence

<400>  214

Thr Leu Ala Ile Ile Lys Pro Asp Ile Val Asp Lys Glu Glu Glu Ile 
1               5                   10                  15      


Gln Asp Ile Ile Leu Arg Ser Gly Phe Thr Ile Val Gln Arg Arg Lys 
            20                  25                  30          


Leu Arg Leu Ser Pro Glu Gln Cys Ser Asn Phe Tyr Val Glu Lys Tyr 
        35                  40                  45              


Gly Lys Met Phe Phe Pro Asn Leu Thr Ala Tyr Met Ser Ser Gly Pro 
    50                  55                  60                  


Leu Val Ala Met Ile Leu Ala Arg His Lys Ala Ile Ser Tyr Trp Leu 
65                  70                  75                  80  


Glu Leu Leu Gly Pro Asn Asn Ser Leu Val Ala Lys Glu Thr His Pro 
                85                  90                  95      


Asp Ser Leu Arg Ala Ile Tyr Gly Thr Asp Asp Leu Arg Asn Ala Leu 
            100                 105                 110         


His Gly Ser Asn Asp Phe Ala Ala Ala Glu Arg Glu Ile Arg Phe Met 
        115                 120                 125             


Phe 
    


<210>  215
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  215

Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile 
1               5                   10                  15      


Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met 
            20                  25                  30          


Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln 
        35                  40                  45              


Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro 
    50                  55                  60                  


Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys 
65                  70                  75                  80  


Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser 
                85                  90                  95      


Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala 
            100                 105                 110         


His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe 
        115                 120                 125             


Phe 
    


<210>  216
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6 partial sequence

<400>  216

Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu Ile Leu 
1               5                   10                  15      


Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile Val Arg 
            20                  25                  30          


Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe Tyr Arg 
        35                  40                  45              


Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe Met Ala 
    50                  55                  60                  


Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala Ile Gln 
65                  70                  75                  80  


Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala Arg His 
                85                  90                  95      


Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp Thr Arg 
            100                 105                 110         


Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg Glu Ile 
        115                 120                 125             


Ala Ala Phe Phe 
    130         


<210>  217
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B partial sequence

<400>  217

Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly 
1               5                   10                  15      


Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met 
            20                  25                  30          


Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val 
        35                  40                  45              


Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr 
    50                  55                  60                  


Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys 
65                  70                  75                  80  


Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His 
                85                  90                  95      


Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln 
            100                 105                 110         


Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val 
        115                 120                 125             


Gln Tyr Phe Phe 
    130         


<210>  218
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6 partial sequence

<400>  218

Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu Ile Leu 
1               5                   10                  15      


Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile Val Arg 
            20                  25                  30          


Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe Tyr Arg 
        35                  40                  45              


Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe Met Ala 
    50                  55                  60                  


Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala Ile Gln 
65                  70                  75                  80  


Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala Arg His 
                85                  90                  95      


Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp Thr Arg 
            100                 105                 110         


Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg Glu Ile 
        115                 120                 125             


Ala Ala Phe Phe 
    130         


<210>  219
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  219

Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly 
1               5                   10                  15      


Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu 
            20                  25                  30          


Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp 
        35                  40                  45              


His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr 
    50                  55                  60                  


Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu 
65                  70                  75                  80  


Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp 
                85                  90                  95      


Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn 
            100                 105                 110         


Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu 
        115                 120                 125             


Leu Phe Phe 
    130     


<210>  220
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8 partial sequence

<400>  220

Glu Lys Thr Leu Ala Leu Leu Arg Pro Asn Leu Phe His Glu Arg Lys 
1               5                   10                  15      


Asp Asp Val Leu Arg Ile Ile Lys Asp Glu Asp Phe Lys Ile Leu Glu 
            20                  25                  30          


Gln Arg Gln Val Val Leu Ser Glu Lys Glu Ala Gln Ala Leu Cys Lys 
        35                  40                  45              


Glu Tyr Glu Asn Glu Asp Tyr Phe Asn Lys Leu Ile Glu Asn Met Thr 
    50                  55                  60                  


Ser Gly Pro Ser Leu Ala Leu Val Leu Leu Arg Asp Asn Gly Leu Gln 
65                  70                  75                  80  


Tyr Trp Lys Gln Leu Leu Gly Pro Arg Thr Val Glu Glu Ala Ile Glu 
                85                  90                  95      


Tyr Phe Pro Glu Ser Leu Cys Ala Gln Phe Ala Met Asp Ser Leu Pro 
            100                 105                 110         


Val Asn Gln Leu Tyr Gly Ser Asp Ser Leu Glu Thr Ala Glu Arg Glu 
        115                 120                 125             


Ile Gln His Phe Phe 
    130             


<210>  221
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B partial sequence

<400>  221

Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly 
1               5                   10                  15      


Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu 
            20                  25                  30          


Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp 
        35                  40                  45              


His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr 
    50                  55                  60                  


Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu 
65                  70                  75                  80  


Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp 
                85                  90                  95      


Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn 
            100                 105                 110         


Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125         


<210>  222
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8 partial sequence

<400>  222

Gln Ser Thr Leu Gly Leu Ile Lys Pro His Ala Thr Ser Glu Gln Arg 
1               5                   10                  15      


Glu Gln Ile Leu Lys Ile Val Lys Glu Ala Gly Phe Asp Leu Thr Gln 
            20                  25                  30          


Val Lys Lys Met Phe Leu Thr Pro Glu Gln Ile Glu Lys Ile Tyr Pro 
        35                  40                  45              


Lys Val Thr Gly Lys Asp Phe Tyr Lys Asp Leu Leu Glu Met Leu Ser 
    50                  55                  60                  


Val Gly Pro Ser Met Val Met Ile Leu Thr Lys Trp Asn Ala Val Ala 
65                  70                  75                  80  


Glu Trp Arg Arg Leu Met Gly Pro Thr Asp Pro Glu Glu Ala Lys Leu 
                85                  90                  95      


Leu Ser Pro Asp Ser Ile Arg Ala Gln Phe Gly Ile Ser Lys Leu Lys 
            100                 105                 110         


Asn Ile Val His Gly Ala Ser Asn Ala Tyr Glu Ala Lys Glu Val 
        115                 120                 125         


<210>  223
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  223

Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile 
1               5                   10                  15      


Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met 
            20                  25                  30          


Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln 
        35                  40                  45              


Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly 
    50                  55                  60              


<210>  224
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8 partial sequence

<400>  224

Ser Ile Ala Ile Ile Lys Pro Asp Ala Val Ile Ser Lys Lys Val Leu 
1               5                   10                  15      


Glu Ile Lys Arg Lys Ile Thr Lys Ala Gly Phe Ile Ile Glu Ala Glu 
            20                  25                  30          


His Lys Thr Val Leu Thr Glu Glu Gln Val Val Asn Phe Tyr Ser Arg 
        35                  40                  45              


Ile Ala Asp Gln Cys Asp Phe Glu Glu Phe Val Ser Phe Met Thr Ser 
    50                  55                  60                  


Gly 
65  


<210>  225
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B partial sequence

<400>  225

Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly 
1               5                   10                  15      


Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met 
            20                  25                  30          


Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val 
        35                  40                  45              


Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr 
    50                  55                  60                  


Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys 
65                  70                  75                  80  


Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His 
                85                  90                  95      


Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln 
            100                 105                 110         


Asn Ala Val His 
        115     


<210>  226
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8 partial sequence

<400>  226

Thr Leu Gly Leu Ile Lys Pro His Ala Thr Ser Glu Gln Arg Glu Gln 
1               5                   10                  15      


Ile Leu Lys Ile Val Lys Glu Ala Gly Phe Asp Leu Thr Gln Val Lys 
            20                  25                  30          


Lys Met Phe Leu Thr Pro Glu Gln Ile Glu Lys Ile Tyr Pro Lys Val 
        35                  40                  45              


Thr Gly Lys Asp Phe Tyr Lys Asp Leu Leu Glu Met Leu Ser Val Gly 
    50                  55                  60                  


Pro Ser Met Val Met Ile Leu Thr Lys Trp Asn Ala Val Ala Glu Trp 
65                  70                  75                  80  


Arg Arg Leu Met Gly Pro Thr Asp Pro Glu Glu Ala Lys Leu Leu Ser 
                85                  90                  95      


Pro Asp Ser Ile Arg Ala Gln Phe Gly Ile Ser Lys Leu Lys Asn Ile 
            100                 105                 110         


Val His 
        


<210>  227
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  227

Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
1               5                   10                  15      


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
            20                  25                  30          


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
        35                  40                  45              


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
    50                  55                  60                  


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
65                  70                  75                  80  


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
                85                  90                  95      


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
            100                 105                 110         


Tyr Phe Phe 
        115 


<210>  228
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8 partial sequence

<400>  228

Val Leu Arg Ile Ile Lys Asp Glu Asp Phe Lys Ile Leu Glu Gln Arg 
1               5                   10                  15      


Gln Val Val Leu Ser Glu Lys Glu Ala Gln Ala Leu Cys Lys Glu Tyr 
            20                  25                  30          


Glu Asn Glu Asp Tyr Phe Asn Lys Leu Ile Glu Asn Met Thr Ser Gly 
        35                  40                  45              


Pro Ser Leu Ala Leu Val Leu Leu Arg Asp Asn Gly Leu Gln Tyr Trp 
    50                  55                  60                  


Lys Gln Leu Leu Gly Pro Arg Thr Val Glu Glu Ala Ile Glu Tyr Phe 
65                  70                  75                  80  


Pro Glu Ser Leu Cys Ala Gln Phe Ala Met Asp Ser Leu Pro Val Asn 
                85                  90                  95      


Gln Leu Tyr Gly Ser Asp Ser Leu Glu Thr Ala Glu Arg Glu Ile Gln 
            100                 105                 110         


His Phe Phe 
        115 


<210>  229
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B partial sequence

<400>  229

Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys Ile Leu 
1               5                   10                  15      


Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln Met Phe 
            20                  25                  30          


Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr Lys Gly 
        35                  40                  45              


Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser Gly Pro 
    50                  55                  60                  


Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr Phe Arg 
65                  70                  75                  80  


Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg Pro 
                85                  90                  95      


Gly Thr Leu Arg 
            100 


<210>  230
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8 partial sequence

<400>  230

Ile Ile Lys Pro Asp Ala Val Ile Ser Lys Lys Val Leu Glu Ile Lys 
1               5                   10                  15      


Arg Lys Ile Thr Lys Ala Gly Phe Ile Ile Glu Ala Glu His Lys Thr 
            20                  25                  30          


Val Leu Thr Glu Glu Gln Val Val Asn Phe Tyr Ser Arg Ile Ala Asp 
        35                  40                  45              


Gln Cys Asp Phe Glu Glu Phe Val Ser Phe Met Thr Ser Gly Leu Ser 
    50                  55                  60                  


Tyr Ile Leu Val Val Ser Gln Gly Ser Lys His Asn Pro Pro Ser Glu 
65                  70                  75                  80  


Glu Thr Glu Pro Gln Thr Asp Thr Glu Pro Asn Glu Arg Ser Glu Asp 
                85                  90                  95      


Gln Pro Glu Val Glu Ala Gln Val Thr Pro Gly Met Met Lys 
            100                 105                 110 


<210>  231
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME9

<400>  231

Met Leu Ser Ser Lys Gly Leu Thr Val Val Asp Val Tyr Gln Gly Trp 
1               5                   10                  15      


Cys Gly Pro Cys Lys Pro Val Val Ser Leu Phe Gln Lys Met Arg Ile 
            20                  25                  30          


Glu Val Gly Leu Asp Leu Leu His Phe Ala Leu Ala Glu Ala Asp Arg 
        35                  40                  45              


Leu Asp Val Leu Glu Lys Tyr Arg Gly Lys Cys Glu Pro Thr Phe Leu 
    50                  55                  60                  


Phe Tyr Ala Ile Lys Asp Glu Ala Leu Ser Asp Glu Asp Glu Cys Val 
65                  70                  75                  80  


Ser His Gly Lys Asn Asn Gly Glu Asp Glu Asp Met Val Ser Ser Glu 
                85                  90                  95      


Arg Thr Cys Thr Leu Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly 
            100                 105                 110         


Lys Thr Asp Glu Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile 
        115                 120                 125             


Leu Thr Asn Glu Glu Arg Thr Met Thr Glu Ala Glu Val Arg Leu Phe 
    130                 135                 140                 


Tyr Gln His Lys Ala Gly Glu Ser Pro Ser Ser Val Arg His Arg Asn 
145                 150                 155                 160 


Ala Leu Gln Cys Arg Pro Trp Lys Pro Gly Gln Arg Arg Cys 
                165                 170                 


<210>  232
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  232

Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile 
1               5                   10                  15      


Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met 
            20                  25                  30          


Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Ala Met Glu Ile 
        35                  40                  45              


Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys 
    50                  55              


<210>  233
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME9 partial sequence

<400>  233

Thr Leu Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly Lys Thr Asp 
1               5                   10                  15      


Glu Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile Leu Thr Asn 
            20                  25                  30          


Glu Glu Arg Thr Met Thr Glu Ala Glu Val Arg Leu Phe Tyr Thr Leu 
        35                  40                  45              


Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly Lys 
    50                  55                  60  


<210>  234
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  234

Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe 
1               5                   10                  15      


Thr Ile Thr Lys Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala 
            20                  25                  30      


<210>  235
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME9 partial sequence

<400>  235

Ile Gln Glu Ala Gly Phe Glu Ile Leu Thr Asn Glu Glu Arg Thr Met 
1               5                   10                  15      


Thr Glu Ala Glu Val Arg Leu Phe Tyr Gln His Lys Ala 
            20                  25                  


<210>  236
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B partial sequence

<400>  236

Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
1               5                   10                  15      


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
            20                  25                  30          


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
        35                  40                  45              


Glu Val Tyr Lys Gly 
    50              


<210>  237
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME9 partial sequence

<400>  237

Thr Cys Thr Leu Ala Ile Ile Lys Pro Asp Ala Val Ala His Gly Lys 
1               5                   10                  15      


Thr Asp Glu Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile Leu 
            20                  25                  30          


Thr Asn Glu Glu Arg Thr Met Thr Glu Ala Glu Val Arg Leu Phe Tyr 
        35                  40                  45              


Gln His Lys Ala Gly 
    50              


<210>  238
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10

<400>  238

Met Gly Cys Phe Phe Ser Lys Arg Arg Lys Ala Asp Lys Glu Ser Arg 
1               5                   10                  15      


Pro Glu Asn Glu Glu Glu Arg Pro Lys Gln Tyr Ser Trp Asp Gln Arg 
            20                  25                  30          


Glu Lys Val Asp Pro Lys Asp Tyr Met Phe Ser Gly Leu Lys Asp Glu 
        35                  40                  45              


Thr Val Gly Arg Leu Pro Gly Thr Val Ala Gly Gln Gln Phe Leu Ile 
    50                  55                  60                  


Gln Asp Cys Glu Asn Cys Asn Ile Tyr Ile Phe Asp His Ser Ala Thr 
65                  70                  75                  80  


Val Thr Ile Asp Asp Cys Thr Asn Cys Ile Ile Phe Leu Gly Pro Val 
                85                  90                  95      


Lys Gly Ser Val Phe Phe Arg Asn Cys Arg Asp Cys Lys Cys Thr Leu 
            100                 105                 110         


Ala Cys Gln Gln Phe Arg Val Arg Asp Cys Arg Lys Leu Glu Val Phe 
        115                 120                 125             


Leu Cys Cys Ala Thr Gln Pro Ile Ile Glu Ser Ser Ser Asn Ile Lys 
    130                 135                 140                 


Phe Gly Cys Phe Gln Trp Tyr Tyr Pro Glu Leu Ala Phe Gln Phe Lys 
145                 150                 155                 160 


Asp Ala Gly Leu Ser Ile Phe Asn Asn Thr Trp Ser Asn Ile His Asp 
                165                 170                 175     


Phe Thr Pro Val Ser Gly Glu Leu Asn Trp Ser Leu Leu Pro Glu Asp 
            180                 185                 190         


Ala Val Val Gln Asp Tyr Val Pro Ile Pro Thr Thr Glu Glu Leu Lys 
        195                 200                 205             


Ala Val Arg Val Ser Thr Glu Ala Asn Arg Ser Ile Val Pro Ile Ser 
    210                 215                 220                 


Arg Gly Gln Arg Gln Lys Ser Ser Asp Glu Ser Cys Leu Val Val Leu 
225                 230                 235                 240 


Phe Ala Gly Asp Tyr Thr Ile Ala Asn Ala Arg Lys Leu Ile Asp Glu 
                245                 250                 255     


Met Val Gly Lys Gly Phe Phe Leu Val Gln Thr Lys Glu Val Ser Met 
            260                 265                 270         


Lys Ala Glu Asp Ala Gln Arg Val Phe Arg Glu Lys Ala Pro Asp Phe 
        275                 280                 285             


Leu Pro Leu Leu Asn Lys Gly Pro Val Ile Ala Leu Glu Phe Asn Gly 
    290                 295                 300                 


Asp Gly Ala Val Glu Val Cys Gln Leu Ile Val Asn Glu Ile Phe Asn 
305                 310                 315                 320 


Gly Thr Lys Met Phe Val Ser Glu Ser Lys Glu Thr Ala Ser Gly Asp 
                325                 330                 335     


Val Asp Ser Phe Tyr Asn Phe Ala Asp Ile Gln Met Gly Ile 
            340                 345                 350 


<210>  239
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  239

Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly 
1               5                   10                  15      


Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala 
            20                  25                  30          


Leu Asp Phe His Val Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu 
        35                  40                  45              


Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg 
    50                  55                  60                  


Asp Asp Ala Ile 
65              


<210>  240
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10 partial sequence

<400>  240

Thr Ile Ala Asn Ala Arg Lys Leu Ile Asp Glu Met Val Gly Lys Gly 
1               5                   10                  15      


Phe Phe Leu Val Gln Thr Lys Glu Val Ser Met Lys Ala Glu Asp Ala 
            20                  25                  30          


Gln Arg Val Phe Arg Glu Lys Ala Pro Asp Phe Leu Pro Leu Leu Asn 
        35                  40                  45              


Lys Gly Pro Val Ile Ala Leu Glu Phe Asn Gly Asp Gly Ala Val 
    50                  55                  60              


<210>  241
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  241

Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp 
1               5                   10                  15      


Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala 
            20                  25                  30          


Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp 
        35                  40              


<210>  242
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10 partial sequence

<400>  242

Pro Ile Pro Thr Thr Glu Glu Leu Lys Ala Val Arg Val Ser Thr Glu 
1               5                   10                  15      


Ala Asn Arg Ser Ile Val Pro Ile Ser Arg Gly Gln Arg Gln Lys Ser 
            20                  25                  30          


Ser Asp Glu Ser Cys Leu Val Val Leu Phe Ala Gly Asp 
        35                  40                  45  


<210>  243
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7A partial sequence

<400>  243

Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile Ile 
1               5                   10                  15      


Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu Ser 
            20                  25                  30          


Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro Phe 
        35                  40                  45              


Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala Met 
    50                  55                  60                  


Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu 
65                  70                  


<210>  244
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10 partial sequence

<400>  244

Val Asp Pro Lys Asp Tyr Met Phe Ser Gly Leu Lys Asp Glu Thr Val 
1               5                   10                  15      


Gly Arg Leu Pro Gly Thr Val Ala Gly Gln Gln Phe Leu Ile Gln Asp 
            20                  25                  30          


Cys Glu Asn Cys Asn Ile Tyr Ile Phe Asp His Ser Ala Thr Val Thr 
        35                  40                  45              


Ile Asp Asp Cys Thr Asn Cys Ile Ile Phe Leu Gly Pro Val Lys Gly 
    50                  55                  60                  


Ser Val Phe Phe Arg Asn Cys Arg Asp Cys Lys 
65                  70                  75  


<210>  245
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7B partial sequence

<400>  245

Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
1               5                   10                  15      


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            20                  25                  30          


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val 
        35                  40                  45          


<210>  246
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10 partial sequence

<400>  246

Cys Cys Ala Thr Gln Pro Ile Ile Glu Ser Ser Ser Asn Ile Lys Phe 
1               5                   10                  15      


Gly Cys Phe Gln Trp Tyr Tyr Pro Glu Leu Ala Phe Gln Phe Lys Asp 
            20                  25                  30          


Ala Gly Leu Ser Ile Phe Asn Asn Thr Trp Ser Asn Ile His Asp Phe 
        35                  40                  45              


Thr Pro Val 
    50      


<210>  247
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2A1

<400>  247

Arg Ala Ser Glu Glu His Leu Lys Gln His Tyr Ile Asp Leu Lys Asp 
1               5                   10                  15      


<210>  248
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2A2

<400>  248

Pro Ala Asp Ser Lys Pro Gly Thr 
1               5               


<210>  249
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2B1

<400>  249

Gln Lys Gly Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu 
1               5                   10                  15      


Glu His Leu Lys 
            20  


<210>  250
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2B2

<400>  250

Ile Asp Leu Lys Asp Arg Pro Phe Pro Gly Leu Val Lys Tyr 
1               5                   10                  


<210>  251
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2B3

<400>  251

Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile Ile His Gly Ser Asp 
1               5                   10                  15      


Ser Val Lys Ser Ala Glu Lys Glu Ile Ser Leu Trp Phe 
            20                  25                  


<210>  252
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3A1

<400>  252

Gln Ala Ser Glu Glu Leu Leu Arg Glu His Tyr Val Glu Leu Arg Glu 
1               5                   10                  15      


<210>  253
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3A1

<400>  253

Pro Gly Asp Ala Thr Pro Gly Thr 
1               5               


<210>  254
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3B1

<400>  254

Arg Lys Gly Phe Lys Leu Val Ala Leu Lys Leu Val Gln Ala Ser Glu 
1               5                   10                  15      


Glu Leu Leu Arg 
            20  


<210>  255
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3B2

<400>  255

Val Glu Leu Arg Glu Arg Pro Phe Tyr Ser Arg Leu Val Lys Tyr 
1               5                   10                  15  


<210>  256
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3B3

<400>  256

Gly Asp Phe Cys Val Glu Val Gly Lys Asn Val Ile His Gly Ser Asp 
1               5                   10                  15      


Ser Val Glu Ser Ala Gln Arg Glu Ile Ala Leu Trp Phe 
            20                  25                  


<210>  257
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4A1

<400>  257

Gln Ala Pro Glu Ser Val Leu Ala Glu His Tyr Gln Asp Leu Arg Arg 
1               5                   10                  15      


<210>  258
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4A2

<400>  258

Ser Ala Glu Ala Ala Pro Gly Thr 
1               5               


<210>  259
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4B1

<400>  259

Arg Arg Gly Phe Thr Leu Val Gly Met Lys Met Leu Gln Ala Pro Glu 
1               5                   10                  15      


Ser Val Leu Ala 
            20  


<210>  260
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4B2

<400>  260

Gln Asp Leu Arg Arg Lys Pro Phe Tyr Pro Ala Leu Ile Arg Tyr 
1               5                   10                  15  


<210>  261
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4B3

<400>  261

Gly Asp Phe Ser Val His Ile Ser Arg Asn Val Ile His Ala Ser Asp 
1               5                   10                  15      


Ser Val Glu Gly Ala Gln Arg Glu Ile Gln Leu Trp Phe 
            20                  25                  


<210>  262
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5A1

<400>  262

Arg Leu Ser Pro Glu Gln Cys Ser Asn Phe Tyr Val Glu Lys Tyr Gly 
1               5                   10                  15      


<210>  263
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5A2

<400>  263

Ser Leu Val Ala Lys Glu Thr His Pro Asp Ser 
1               5                   10      


<210>  264
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5B1

<400>  264

Arg Ser Gly Phe Thr Ile Val Gln Arg Arg Lys Leu Arg Leu Ser Pro 
1               5                   10                  15      


Glu Gln Cys Ser 
            20  


<210>  265
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5B2

<400>  265

Val Glu Lys Tyr Gly Lys Met Phe Phe Pro Asn Leu Thr Ala Tyr 
1               5                   10                  15  


<210>  266
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5B3

<400>  266

Ala Ile Tyr Gly Thr Asp Asp Leu Arg Asn Ala Leu His Gly Ser Asn 
1               5                   10                  15      


Asp Phe Ala Ala Ala Glu Arg Glu Ile Arg Phe Met Phe 
            20                  25                  


<210>  267
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6A1

<400>  267

Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe Tyr Arg Glu His Glu Gly 
1               5                   10                  15      


<210>  268
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6A2

<400>  268

Val Phe Arg Ala Arg His Val Ala Pro Asp Ser 
1               5                   10      


<210>  269
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6B1

<400>  269

Ser Asn Lys Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys 
1               5                   10                  15      


Glu Asp Cys Gln 
            20  


<210>  270
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6B2

<400>  270

Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
1               5                   10                  15  


<210>  271
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6B3

<400>  271

Gly Ser Phe Gly Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp 
1               5                   10                  15      


Ser Val Val Ser Ala Ser Arg Glu Ile Ala Ala Phe Phe 
            20                  25                  


<210>  272
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8A1

<400>  272

Val Leu Ser Glu Lys Glu Ala Gln Ala Leu Cys Lys Glu Tyr Glu Asn 
1               5                   10                  15      


<210>  273
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8A2

<400>  273

Val Glu Glu Ala Ile Glu Tyr Phe Pro Glu Ser 
1               5                   10      


<210>  274
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8A3

<400>  274

Phe Leu Thr Pro Glu Gln Ile Glu Lys Ile Tyr Pro Lys Val Thr Gly 
1               5                   10                  15      


<210>  275
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8A4

<400>  275

Pro Glu Glu Ala Lys Leu Leu Ser Pro Asp Ser 
1               5                   10      


<210>  276
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8A5

<400>  276

Val Leu Thr Glu Glu Gln Val Val Asn Phe Tyr Ser Arg Ile Ala Asp 
1               5                   10                  15      


<210>  277
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B1

<400>  277

Glu Ala Gly Phe Asp Leu Thr Gln Val Lys Lys Met Phe Leu Thr Pro 
1               5                   10                  15      


Glu Gln Ile Glu 
            20  


<210>  278
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B2

<400>  278

Pro Lys Val Thr Gly Lys Asp Phe Tyr Lys Asp Leu Leu Glu Met 
1               5                   10                  15  


<210>  279
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B3

<400>  279

Ala Gln Phe Gly Ile Ser Lys Leu Lys Asn Ile Val His 
1               5                   10              


<210>  280
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B4

<400>  280

Asp Glu Asp Phe Lys Ile Leu Glu Gln Arg Gln Val Val Leu Ser Glu 
1               5                   10                  15      


Lys Glu Ala Gln 
            20  


<210>  281
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B5

<400>  281

Lys Glu Tyr Glu Asn Glu Asp Tyr Phe Asn Lys Leu Ile Glu Asn 
1               5                   10                  15  


<210>  282
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B6

<400>  282

Ala Gln Phe Ala Met Asp Ser Leu Pro Val Asn Gln Leu Tyr Gly Ser 
1               5                   10                  15      


Asp Ser Leu Glu Thr Ala Glu Arg Glu Ile Gln His Phe Phe 
            20                  25                  30  


<210>  283
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B7

<400>  283

Lys Ala Gly Phe Ile Ile Glu Ala Glu His Lys Thr Val Leu Thr Glu 
1               5                   10                  15      


Glu Gln Val Val 
            20  


<210>  284
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B8

<400>  284

Ser Arg Ile Ala Asp Gln Cys Asp Phe Glu Glu Phe Val Ser Phe 
1               5                   10                  15  


<210>  285
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME9A1

<400>  285

Thr Met Thr Glu Ala Glu Val Arg Leu Phe Tyr 
1               5                   10      


<210>  286
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME9B1

<400>  286

Glu Ala Gly Phe Glu Ile Leu Thr Asn Glu Glu Arg Thr Met Thr Glu 
1               5                   10                  15      


Ala Glu Val Arg 
            20  


<210>  287
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10A1

<400>  287

Ser Met Lys Ala Glu Asp Ala Gln Arg Val Phe Arg Glu Lys 
1               5                   10                  


<210>  288
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10A2

<400>  288

Gly Gln Arg Gln Lys Ser Ser Asp Glu Ser 
1               5                   10  


<210>  289
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10A3

<400>  289

Ile Gln Asp Cys Glu Asn Cys Asn Ile Tyr Ile Phe Asp His Ser Ala 
1               5                   10                  15      


<210>  290
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10B1

<400>  290

Glu Leu Ala Phe Gln Phe Lys Asp Ala Gly Leu Ser Ile Phe Asn Asn 
1               5                   10                  15      


Thr Trp Ser Asn Ile His 
            20          


<210>  291
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2A1

<400>  291

Arg Ala Ser Glu Glu His Leu Lys Gln His Tyr Ile Asp Leu Lys Asp 
1               5                   10                  15      


Arg Pro Phe Phe Pro Gly Leu 
            20              


<210>  292
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2A2

<400>  292

Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly 
1               5                   10                  15      


Asp Phe 
        


<210>  293
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2B1

<400>  293

Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg 
1               5                   10                  15      


Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu Lys Gln 
            20                  25                  30          


His Tyr 
        


<210>  294
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2B2

<400>  294

Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu Val Lys Tyr 
1               5                   10                  15      


Met Asn Ser Gly Pro Val Val Ala Met 
            20                  25  


<210>  295
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME2B3

<400>  295

Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile 
1               5                   10                  15      


Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys Glu Ile Ser Leu 
            20                  25                  30          


Trp Phe 
        


<210>  296
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3A1

<400>  296

Leu Lys Leu Val Gln Ala Ser Glu Glu Leu Leu Arg Glu His Tyr Val 
1               5                   10                  15      


Glu Leu Arg Glu Arg Pro Phe Tyr Ser Arg Leu 
            20                  25          


<210>  297
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3A1

<400>  297

Leu Ile Gly Ala Thr Asp Pro Gly Asp Ala Thr Pro Gly Thr Ile Arg 
1               5                   10                  15      


Gly Asp Phe 
            


<210>  298
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3B1

<400>  298

Leu Val Gly Glu Ile Val Arg Arg Phe Glu Arg Lys Gly Phe Lys Leu 
1               5                   10                  15      


Val Ala Leu Lys Leu Val Gln Ala Ser Glu Glu Leu Leu Arg Glu 
            20                  25                  30      


<210>  299
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3B2

<400>  299

Glu His Tyr Val Glu Leu Arg Glu Arg Pro Phe Tyr Ser Arg Leu Val 
1               5                   10                  15      


Lys Tyr Met Gly Ser Gly Pro Val Val Ala Met 
            20                  25          


<210>  300
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME3B3

<400>  300

Pro Gly Thr Ile Arg Gly Asp Phe Cys Val Glu Val Gly Lys Asn Val 
1               5                   10                  15      


Ile His Gly Ser Asp Ser Val Glu Ser Ala Gln Arg Glu Ile Ala Leu 
            20                  25                  30          


Trp Phe 
        


<210>  301
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4A1

<400>  301

Gly Phe Thr Leu Val Gly Met Lys Met Leu Gln Ala Pro Glu Ser Val 
1               5                   10                  15      


Leu Ala Glu His Tyr Gln Asp Leu Arg Arg Lys Pro Phe 
            20                  25                  


<210>  302
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4A2

<400>  302

Gly His Thr Asp Ser Ala Glu Ala Ala Pro Gly Thr Ile Arg Gly Asp 
1               5                   10                  15      


Phe 
    


<210>  303
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4B1

<400>  303

Leu Val Gly Asp Val Ile Gln Arg Phe Glu Arg Arg Gly Phe Thr Leu 
1               5                   10                  15      


Val Gly Met Lys Met Leu Gln Ala Pro Glu Ser Val Leu Ala Glu His 
            20                  25                  30          


Tyr 
    


<210>  304
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4B2

<400>  304

Glu His Tyr Gln Asp Leu Arg Arg Lys Pro Phe Tyr Pro Ala Leu Ile 
1               5                   10                  15      


Arg Tyr Met Ser Ser Gly Pro Val Val Ala Met 
            20                  25          


<210>  305
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME4B3

<400>  305

Pro Gly Thr Ile Arg Gly Asp Phe Ser Val His Ile Ser Arg Asn Val 
1               5                   10                  15      


Ile His Ala Ser Asp Ser Val Glu Gly Ala Gln Arg Glu Ile Gln Leu 
            20                  25                  30          


Trp Phe 
        


<210>  306
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5A1

<400>  306

Gly Phe Thr Ile Val Gln Arg Arg Lys Leu Arg Leu Ser Pro Glu Gln 
1               5                   10                  15      


Cys Ser Asn Phe Tyr Val Glu Lys Tyr Gly Lys Met Phe Phe 
            20                  25                  30  


<210>  307
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5A2

<400>  307

Leu Leu Gly Pro Asn Asn Ser Leu Val Ala Lys Glu Thr His Pro Asp 
1               5                   10                  15      


Ser Leu Arg Ala Ile Tyr Gly Thr Asp 
            20                  25  


<210>  308
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5B1

<400>  308

Ile Gln Asp Ile Ile Leu Arg Ser Gly Phe Thr Ile Val Gln Arg Arg 
1               5                   10                  15      


Lys Leu Arg Leu Ser Pro Glu Gln Cys Ser Asn Phe Tyr 
            20                  25                  


<210>  309
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5B2

<400>  309

Phe Tyr Val Glu Lys Tyr Gly Lys Met Phe Phe Pro Asn Leu Thr Ala 
1               5                   10                  15      


Tyr Met Ser Ser Gly Pro Leu Val Ala Met 
            20                  25      


<210>  310
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME5B3

<400>  310

Pro Asp Ser Leu Arg Ala Ile Tyr Gly Thr Asp Asp Leu Arg Asn Ala 
1               5                   10                  15      


Leu His Gly Ser Asn Asp Phe Ala Ala Ala Glu Arg Glu Ile Arg Phe 
            20                  25                  30          


Met Phe 
        


<210>  311
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6A1

<400>  311

Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
1               5                   10                  15      


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
            20                  25                  30          


<210>  312
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6A2

<400>  312

Leu Met Gly Pro Thr Arg Val Phe Arg Ala Arg His Val Ala Pro Asp 
1               5                   10                  15      


Ser Ile Arg Gly Ser Phe Gly 
            20              


<210>  313
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6B1

<400>  313

Ile Leu Ser Asn Lys Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp 
1               5                   10                  15      


Arg Lys Glu Asp Cys Gln Arg Phe Tyr 
            20                  25  


<210>  314
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6B2

<400>  314

Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu 
1               5                   10                  15      


Phe Met Ala Ser Gly Pro Ile Arg Ala 
            20                  25  


<210>  315
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME6B3

<400>  315

Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr 
1               5                   10                  15      


Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser 
            20                  25                  30          


Arg Glu Ile Ala Ala Phe Phe 
        35                  


<210>  316
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8A1

<400>  316

Phe Lys Ile Leu Glu Gln Arg Gln Val Val Leu Ser Glu Lys Glu Ala 
1               5                   10                  15      


Gln Ala Leu Cys Lys Glu Tyr Glu Asn Glu Asp Tyr Phe Asn Lys Leu 
            20                  25                  30          


Ile 
    


<210>  317
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8A2

<400>  317

Trp Lys Gln Leu Leu Gly Pro Arg Thr Val Glu Glu Ala Ile Glu Tyr 
1               5                   10                  15      


Phe Pro Glu Ser Leu Cys Ala Gln Phe Ala Met Asp 
            20                  25              


<210>  318
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8A3

<400>  318

Ala Gly Phe Asp Leu Thr Gln Val Lys Lys Met Phe Leu Thr Pro Glu 
1               5                   10                  15      


Gln Ile Glu Lys Ile Tyr Pro Lys Val Thr Gly Lys Asp Phe Tyr Lys 
            20                  25                  30          


Asp Leu 
        


<210>  319
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8A4

<400>  319

Glu Trp Arg Arg Leu Met Gly Pro Thr Asp Pro Glu Glu Ala Lys Leu 
1               5                   10                  15      


Leu Ser Pro Asp Ser Ile Arg Ala Gln Phe Gly 
            20                  25          


<210>  320
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8A5

<400>  320

Lys Ala Gly Phe Ile Ile Glu Ala Glu His Lys Thr Val Leu Thr Glu 
1               5                   10                  15      


Glu Gln Val Val Asn Phe Tyr Ser Arg Ile Ala Asp Gln Cys Asp Phe 
            20                  25                  30          


Glu Glu 
        


<210>  321
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B1

<400>  321

Ile Leu Lys Ile Val Lys Glu Ala Gly Phe Asp Leu Thr Gln Val Lys 
1               5                   10                  15      


Lys Met Phe Leu Thr Pro Glu Gln Ile Glu Lys Ile Tyr 
            20                  25                  


<210>  322
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B2

<400>  322

Tyr Pro Lys Val Thr Gly Lys Asp Phe Tyr Lys Asp Leu Leu Glu Met 
1               5                   10                  15      


Leu Ser Val Gly Pro 
            20      


<210>  323
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B3

<400>  323

Asp Pro Glu Glu Ala Lys Leu Leu Ser Pro Asp Ser Ile Arg Ala Gln 
1               5                   10                  15      


Phe Gly Ile Ser Lys Leu Lys Asn Ile Val His 
            20                  25          


<210>  324
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B4

<400>  324

Leu Arg Ile Ile Lys Asp Glu Asp Phe Lys Ile Leu Glu Gln Arg Gln 
1               5                   10                  15      


Val Val Leu Ser Glu Lys Glu Ala Gln 
            20                  25  


<210>  325
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B5

<400>  325

Lys Glu Tyr Glu Asn Glu Asp Tyr Phe Asn Lys Leu Ile Glu Asn Met 
1               5                   10                  15      


Thr Ser Gly Pro Ser Leu Ala 
            20              


<210>  326
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B6

<400>  326

Pro Glu Ser Leu Cys Ala Gln Phe Ala Met Asp Ser Leu Pro Val Asn 
1               5                   10                  15      


Gln Leu Tyr Gly Ser Asp Ser Leu Glu Thr Ala Glu Arg Glu Ile Gln 
            20                  25                  30          


His Phe Phe 
        35  


<210>  327
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B7

<400>  327

Ile Lys Arg Lys Ile Thr Lys Ala Gly Phe Ile Ile Glu Ala Glu His 
1               5                   10                  15      


Lys Thr Val Leu Thr Glu Glu Gln Val Val Asn Phe Tyr 
            20                  25                  


<210>  328
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME8B8

<400>  328

Phe Tyr Ser Arg Ile Ala Asp Gln Cys Asp Phe Glu Glu Phe Val Ser 
1               5                   10                  15      


Phe Met Thr Ser Gly 
            20      


<210>  329
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME9A1

<400>  329

Ala Gly Phe Glu Ile Leu Thr Asn Glu Glu Arg Thr Met Thr Glu Ala 
1               5                   10                  15      


Glu Val Arg Leu Phe Tyr 
            20          


<210>  330
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME9B1

<400>  330

Ile Ile Met Lys Ile Gln Glu Ala Gly Phe Glu Ile Leu Thr Asn Glu 
1               5                   10                  15      


Glu Arg Thr Met Thr Glu Ala Glu Val Arg Leu Phe Tyr 
            20                  25                  


<210>  331
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10A1

<400>  331

Gly Phe Phe Leu Val Gln Thr Lys Glu Val Ser Met Lys Ala Glu Asp 
1               5                   10                  15      


Ala Gln Arg Val Phe Arg Glu Lys Ala Pro 
            20                  25      


<210>  332
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10A2

<400>  332

Glu Ala Asn Arg Ser Ile Val Pro Ile Ser Arg Gly Gln Arg Gln Lys 
1               5                   10                  15      


Ser Ser Asp Glu Ser Cys Leu Val Val Leu Phe Ala Gly Asp 
            20                  25                  30  


<210>  333
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10A3

<400>  333

Ile Gln Asp Cys Glu Asn Cys Asn Ile Tyr Ile Phe Asp His Ser Ala 
1               5                   10                  15      


<210>  334
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME10B1

<400>  334

Glu Leu Ala Phe Gln Phe Lys Asp Ala Gly Leu Ser Ile Phe Asn Asn 
1               5                   10                  15      


Thr Trp Ser Asn Ile His Asp Phe Thr Pro Val Asp Cys Thr 
            20                  25                  30  


<210>  335
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8F9A4A3 Heavy chain variable region sequence mouse

<400>  335
gtccagctgc aacagtctgg acctgaactg gtgaagcctg gggcttcagt gaagatatcc       60

tgcaagactt ctggaaacac attcactgaa tacaccatgc actgggtgaa gcagagccat      120

ggaaagagcc ttgagtggat tggaggtttt aatcctaaca atggtgttac taactacaac      180

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      240

gagctccgca gcctgacatc tgaggattct gcagtctatt actgtgcaag acggtactac      300

catagtctct acgtgtttta ctttgactac tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  336
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV1-24*01 V-REGION sequence human (closest match hu antibody 
       sequence)

<400>  336
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggata caccctcact gaattatcca tgcactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatggtga aacaatctac      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aaca            294


<210>  337
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHJ4*01 J-REGION sequence human (closest match hu antibody 
       sequence)

<400>  337
tactttgact actggggcca aggaaccctg gtcaccgtct cctca                       45


<210>  338
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A4A3 Heavy chain variable region sequence

<400>  338
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggaaa cacattcact gaatacacca tgcactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggt tttaatccta acaatggtgt tactaactac      180

aaccagaagt tcaagggcag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagacggtac      300

taccatagtc tctacgtgtt ttactttgac tactggggcc aaggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  339
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A4A3 Heavy chain variable region sequence (codon 
       optimized)

<400>  339
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg tgtccggaaa taccttcacc gagtacacca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg gatgggcggc ttcaacccca acaacggcgt gaccaactac      180

aaccagaaat tcaagggccg cgtgaccatg accgaggaca caagcacaga caccgcctac      240

atggaactga gcagcctgag aagcgaggac accgccgtgt actactgcgc cagaaggtac      300

taccacagcc tgtacgtgtt ctacttcgac tactggggcc agggcaccct ggtcacagtt      360

tcttct                                                                 366


<210>  340
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A4A3 Heavy chain variable region sequence)

<400>  340
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggaaa cacattcact gaatacacca tgcactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gattggaggt tttaatccta acaatggtgt tactaactac      180

aaccagaagt tcaagggcaa agtcaccctg accgtggaca catctagcag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagacggtac      300

taccatagtc tctacgtgtt ttactttgac tactggggcc aaggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  341
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A4A3 Heavy chain variable region sequence 
       (codon optimized)

<400>  341
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg tgtccggaaa taccttcacc gagtacacca tgcactgggt ccgacaggcc      120

cctggcaaag gactggaatg gatcggcggc ttcaacccca acaacggcgt gaccaactac      180

aaccagaaat tcaagggcaa agtgaccctg accgtggaca ccagcagcag cacagcctac      240

atggaactga gcagcctgag aagcgaggac accgccgtgt actactgcgc cagaaggtac      300

taccacagcc tgtacgtgtt ctacttcgac tactggggcc agggcaccct ggtcacagtt      360

tcttct                                                                 366


<210>  342
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8F9A4A3 Light chain variable region sequence mouse

<400>  342
gaaacaactg tgacccagtc tccagcatcc ctgtccatgg ctataggaga aaaagtcacc       60

atcagatgca taaccagcac tgatattgat gatgatatga actggtacca gcagaagcca      120

ggggaacctc ctaagctcct tatttcagaa ggcaatactc ttcgtcctgg agtcccatcc      180

cgattctcca gcagtggcta tggtacagat tttgttttta caattgaaaa catgctctca      240

gaagatgttg cagattacta ctgtttgcaa agtgataact tgcctctcac gttcggctcg      300

gggacaaagt tggaaataaa acgg                                             324


<210>  343
<211>  264
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV5-2*01 V-REGION sequence human (closest match hu antibody 
       sequence)

<400>  343
gaaacgacac tcacgcagtc tccagcattc atgtcagcga ctccaggaga caaagtcaac       60

atctcctgca aagccagcca agacattgat gatgatatga actggtacca acagaaacca      120

ggagaagctg ctattttcat tattcaagaa gctactactc tcgttcctgg aatcccacct      180

cgattcagtg gcagcgggta tggaacagat tttaccctca caattaataa catagaatct      240

gaggatgctg catattactt ctgt                                             264


<210>  344
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKJ4*02 J-REGION sequence human (closest match hu antibody 
       sequence)

<400>  344
ctcacgttcg gcggagggac caaggtggag atcaaa                                 36


<210>  345
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A4A3 Light chain variable region sequence

<400>  345
gaaacgacac tcacgcagtc tccagcattc atgtcagcga ctccaggaga caaagtcaac       60

atctcctgca taaccagcac tgatattgat gatgatatga actggtacca acagaaacca      120

ggagaagctg ctattttcat tattcaagaa ggcaatactc ttcgtcctgg aatcccacct      180

cgattcagtg gcagcgggta tggaacagat tttaccctca caattaataa catagaatct      240

gaggatgctg catattactt ctgtttgcaa agtgataact tgcctctcac gttcggcgga      300

gggaccaagg tggagatcaa acgg                                             324


<210>  346
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A4A3 Light chain variable region sequence (codon 
       optimized)

<400>  346
gagacaaccc tgacacagag ccctgccttc atgtctgcca cacctggcga caaagtgaac       60

atcagctgca tcaccagcac cgacatcgac gacgacatga actggtatca gcagaagcct      120

ggcgaggccg ccatcttcat catccaagag ggcaacacac tgcggcctgg catccctcct      180

agattttctg gcagcggcta cggcaccgac ttcaccctga ccatcaacaa catcgagagc      240

gaggacgccg cctactactt ctgcctgcaa agcgacaacc tgcctctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gcgg                                             324


<210>  347
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A4A3 Light chain variable region sequence

<400>  347
gaaacgacag tgacgcagtc tccagcattc atgtcagcga ctccaggaga caaagtcacc       60

atctcctgca taaccagcac tgatattgat gatgatatga actggtacca acagaaacca      120

ggagaagctg ctattctgct gattagcgaa ggcaatactc ttcgtcctgg aatcccacct      180

cgattcagta gcagcgggta tggaacagat tttaccctca caattaataa catagaatct      240

gaggatgctg catattactt ctgtttgcaa agtgataact tgcctctcac gttcggcgga      300

gggaccaagg tggagatcaa acgg                                             324


<210>  348
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A4A3 Light chain variable region sequence 
       (codon optimized)

<400>  348
gagacaaccg tgacacagag ccctgccttc atgtctgcca cacctggcga caaagtgacc       60

atcagctgca tcaccagcac cgacatcgac gacgacatga actggtatca gcagaagcct      120

ggcgaggccg ccatcctgct tatctctgag ggaaacacac tgcggcctgg catccctcct      180

agattttcca gcagcggcta cggcaccgac ttcaccctga ccatcaacaa catcgagagc      240

gaggacgccg cctactactt ctgcctgcaa agcgacaacc tgcctctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gcgg                                             324


<210>  349
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A4A3 sequence (codon optimized) - humanized
       heavy and light chains joined via a flexible linker

<400>  349
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg tgtccggaaa taccttcacc gagtacacca tgcactgggt ccgacaggcc      120

cctggcaaag gactggaatg gatcggcggc ttcaacccca acaacggcgt gaccaactac      180

aaccagaaat tcaagggcaa agtgaccctg accgtggaca ccagcagcag cacagcctac      240

atggaactga gcagcctgag aagcgaggac accgccgtgt actactgcgc cagaaggtac      300

taccacagcc tgtacgtgtt ctacttcgac tactggggcc agggcaccct ggtcacagtt      360

tcttctggcg gtggcggaag cggaggcggt ggctccggtg gcggaggcag cgaaacgaca      420

gtgacgcagt ctccagcatt catgtcagcg actccaggag acaaagtcac catctcctgc      480

ataaccagca ctgatattga tgatgatatg aactggtacc aacagaaacc aggagaagct      540

gctattctgc tgattagcga aggcaatact cttcgtcctg gaatcccacc tcgattcagt      600

agcagcgggt atggaacaga ttttaccctc acaattaata acatagaatc tgaggatgct      660

gcatattact tctgtttgca aagtgataac ttgcctctca cgttcggcgg agggaccaag      720

gtggagatca aacgg                                                       735


<210>  350
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8F9A5A1 Heavy chain variable region sequence

<400>  350
atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc       60

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      120

ggaaagggtt taaagtggat gggctggata aacacctaca ctggagagcc aacatatgtt      180

gatgacttca agggacggtt tgccttctct ttggaaacct ctgccaccac tgcctatttg      240

cagatcaaca acctcaaaaa tgaggacacg tctacatatt tctgtgcaag attgaggggg      300

atacgaccgg gtcccttggc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  351
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV7-81*01 V-REGION sequence

<400>  351
caggtgcagc tggtgcagtc tggccatgag gtgaagcagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cagtttcacc acctatggta tgaattgggt gccacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ttcaacacct acactgggaa cccaacatat      180

gcccagggct tcacaggacg gtttgtcttc tccatggaca cctctgccag cacagcatac      240

ctgcagatca gcagcctaaa ggctgaggac atggccatgt attactgtgc gaga            294


<210>  352
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHJ4*03 J-REGION sequence

<400>  352
tactttgact actggggcca agggaccctg gtcaccgtct cctca                       45


<210>  353
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A5A1 Heavy chain variable region sequence

<400>  353
caggtgcagc tggtgcagtc tggccatgag gtgaagcagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gccacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacct acactggaga gccaacatat      180

gttgatgact tcaagggacg gtttgtcttc tccatggaca cctctgccag cacagcatac      240

ctgcagatca gcagcctaaa ggctgaggac atggccatgt attactgtgc aagattgagg      300

gggatacgac cgggtccctt ggcttactgg ggccaaggga ccctggtcac cgtctcctca      360


<210>  354
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A5A1 Heavy chain variable region sequence (codon 
       optimized)

<400>  354
caggttcagc tggtgcagtc tggccacgaa gtgaaacagc ctggcgcctc tgtgaaggtg       60

tcctgtaaag ccagcggcta cacctttacc aactacggca tgaactgggt gccccaggct      120

cctggacaag gcttggaatg gatgggctgg atcaacacct acaccggcga gcctacctac      180

gtggacgact tcaagggcag attcgtgttc agcatggaca ccagcgccag cacagcctac      240

ctgcagatca gctctctgaa ggccgaggat atggccatgt actactgcgc cagactgaga      300

ggcatcagac ctggacctct ggcctattgg ggacagggca cactggtcac agtgtcctct      360


<210>  355
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A5A1 Heavy chain variable region sequence

<400>  355
cagatccagc tggtgcagtc tggccccgag gtgaagcagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacct acactggaga gccaacatat      180

gttgatgact tcaagggacg gtttgccttc tccatggaca cctctgccag cacagcatac      240

ctgcagatca gcagcctaaa ggctgaggac accgccacct attactgtgc aagattgagg      300

gggatacgac cgggtccctt ggcttactgg ggccaaggga ccctggtcac cgtctcctca      360


<210>  356
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A5A1 Heavy chain variable region sequence 
       (codon optimized)

<400>  356
cagattcagc tggtgcagtc tggccccgaa gtgaaacaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cacctttacc aactacggca tgaactgggt caagcaggcc      120

cctggacaag gcctggaatg gatgggctgg atcaacacct acaccggcga gcctacctac      180

gtggacgact tcaagggcag attcgccttc agcatggaca ccagcgccag cacagcctac      240

ctgcagatca gctctctgaa ggccgaggac accgccacct actactgtgc cagactgaga      300

ggcatcagac ccggacctct ggcctattgg ggacagggaa cactggtcac cgtgtcctct      360


<210>  357
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8F9A5A1 Light chain variable region sequence

<400>  357
gaaattttgc tcacccagtc tccagcaatc atagctgcat ctcctgggga gaaggtcacc       60

atcacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaaaccagga      120

tcctccccca aaatatggat ttatggtata tccaacctgg cttctggagt tcctgctcgc      180

ttcagtggca gtgggtctgg gacatctttc tctttcacaa tcaacagcat ggaggctgaa      240

gatgttgcca cttattactg tcagcaaagg agtagttacc cacccacgtt cggagggggg      300

accaagctgg aaataaaacg g                                                321


<210>  358
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV3D-15*02 V-REGION sequence

<400>  358
gaaatagtga tgatgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataac                             279


<210>  359
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKJ4*02 J-REGION sequence

<400>  359
ctcacgttcg gcggagggac caaggtggag atcaaa                                 36


<210>  360
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A5A1 Light chain variable region sequence

<400>  360
gaaatagtga tgatgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaaacctggc      120

caggctccca ggctcctcat ctatggtata tccaacctgg cttctggcat cccagccagg      180

ttcagtggca gtgggtctgg gacagagttc actctcacca tcagcagcct gcagtctgaa      240

gattttgcag tttattactg tcagcaaagg agtagttacc cacccacgtt cggcggaggg      300

accaaggtgg agatcaaacg g                                                321


<210>  361
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A5A1 Light chain variable region sequence (codon 
       optimized)

<400>  361
gagatcgtga tgatgcagag ccccgccaca ctgagtgtgt ctccaggcga aagagccaca       60

ctgtcctgta gcgccagcag cagcgtgtcc tacatgaact ggtatcagca gaagcccgga      120

caggccccta gactgctgat ctacggcatc agcaatctgg ccagcggcat ccctgccaga      180

ttttctggct ctggctccgg caccgagttc accctgacaa tctctagcct gcagagcgag      240

gacttcgccg tgtactactg ccagcagaga agcagctacc ctcctacctt tggcggaggc      300

accaaggtgg aaatcaagcg g                                                321


<210>  362
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A5A1 Light chain variable region sequence

<400>  362
gaaatagtgc tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaaacctggc      120

caggctccca ggctctggat ctatggtata tccaacctgg cttctggcat cccagccagg      180

ttcagtggca gtgggtctgg gacaagcttc agcctcacca tcagcagcct gcagtctgaa      240

gattttgcag tttattactg tcagcaaagg agtagttacc cacccacgtt cggcggaggg      300

accaaggtgg agatcaaacg g                                                321


<210>  363
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A5A1 Light chain variable region sequence 
       (codon optimized)

<400>  363
gagatcgtgc tgacacagtc tcccgccaca ctgagtgtgt ctccaggcga aagagccaca       60

ctgtcctgta gcgccagcag cagcgtgtcc tacatgaact ggtatcagca gaagcccgga      120

caggccccta gactgtggat ctacggcatc agcaatctgg ccagcggcat ccctgccaga      180

ttttctggct ctggctccgg caccagcttc agcctgacaa tcagcagcct gcagagcgag      240

gacttcgccg tgtactactg ccagcagaga agcagctacc ctcctacctt tggcggaggc      300

accaaggtgg aaatcaagcg g                                                321


<210>  364
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A5A1 scFV sequence (codon optimized)

<400>  364
cagattcagc tggtgcagtc tggccccgaa gtgaaacaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cacctttacc aactacggca tgaactgggt caagcaggcc      120

cctggacaag gcctggaatg gatgggctgg atcaacacct acaccggcga gcctacctac      180

gtggacgact tcaagggcag attcgccttc agcatggaca ccagcgccag cacagcctac      240

ctgcagatca gctctctgaa ggccgaggac accgccacct actactgtgc cagactgaga      300

ggcatcagac ccggacctct ggcctattgg ggacagggaa cactggtcac cgtgtcctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgagat cgtgctgaca      420

cagtctcccg ccacactgag tgtgtctcca ggcgaaagag ccacactgtc ctgtagcgcc      480

agcagcagcg tgtcctacat gaactggtat cagcagaagc ccggacaggc ccctagactg      540

tggatctacg gcatcagcaa tctggccagc ggcatccctg ccagattttc tggctctggc      600

tccggcacca gcttcagcct gacaatcagc agcctgcaga gcgaggactt cgccgtgtac      660

tactgccagc agagaagcag ctaccctcct acctttggcg gaggcaccaa ggtggaaatc      720

aagcgg                                                                 726


<210>  365
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8H5H5G4 Heavy chain variable region sequence

<400>  365
gtccagctgc aacagtctgg acctgatctg gtgaagcctg ggacttcagt gaagatatcc       60

tgtaagactt ctggaaacac attcactgaa tacaccatgc actgggtgaa gcagagccat      120

ggaaagagcc ttgagtggat tggaggtttt aatcctaaca atggtgttac taactacaac      180

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      240

gagctccgca gcctgacatc tgaggattct gcagtctatt actgtgcaag acgttactac      300

catagtacct acgtgttcta ctttgactcc tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  366
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV1-24*01 V-REGION sequence

<400>  366
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggata caccctcact gaattatcca tgcactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatggtga aacaatctac      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aaca            294


<210>  367
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHJ4*03 J-REGION sequence

<400>  367
tactttgact actggggcca agggaccctg gtcaccgtct cctca                       45


<210>  368
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 8H5H5G4 Heavy chain variable region sequence

<400>  368
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggaaa cacattcact gaatacacca tgcactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggt tttaatccta acaatggtgt tactaactac      180

aaccagaagt tcaagggcag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagacgttac      300

taccatagta cctacgtgtt ctactttgac tcctggggcc aagggaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  369
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 8H5H5G4 Heavy chain variable region sequence (codon 
       optimized)

<400>  369
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg tgtccggaaa taccttcacc gagtacacca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg gatgggcggc ttcaacccca acaacggcgt gaccaactac      180

aaccagaaat tcaagggccg cgtgaccatg accgaggaca caagcacaga caccgcctac      240

atggaactga gcagcctgag aagcgaggac accgccgtgt actactgcgc cagaaggtac      300

taccacagca cctacgtgtt ctacttcgac agctggggcc agggcacact ggtcacagtt      360

tcttct                                                                 366


<210>  370
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Humanized 8H5H5G4 Heavy chain variable region sequence

<400>  370
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggaaa cacattcact gaatacacca tgcactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatcggaggt tttaatccta acaatggtgt tactaactac      180

aaccagaagt tcaagggcaa ggtcaccctg accgtggaca catctagcag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagacgttac      300

taccatagta cctacgtgtt ctactttgac tcctggggcc aagggaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  371
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Humanized 8H5H5G4 Heavy chain variable region sequence 
       (codon optimized)

<400>  371
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg tgtccggaaa taccttcacc gagtacacca tgcactgggt ccgacaggcc      120

cctggcaaag gactggaatg gatcggcggc ttcaacccca acaacggcgt gaccaactac      180

aaccagaaat tcaagggcaa agtgaccctg accgtggaca ccagcagcag cacagcctac      240

atggaactga gcagcctgag aagcgaggac accgccgtgt actactgcgc cagaaggtac      300

taccacagca cctacgtgtt ctacttcgac agctggggcc agggcacact ggtcacagtt      360

tcttct                                                                 366


<210>  372
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8H5H5G4 Light chain variable region sequence

<400>  372
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattagc aattatttaa actggtttca gcagaaacca      120

gatggaacta ttaagctcct gatctattac acatcaagtt tacattcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagtaa tgtggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttacac gttcggaggg      300

gggaccaagc tggagataaa acgg                                             324


<210>  373
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV1-27*01 V-REGION sequence

<400>  373
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca      120

gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tataacagtg cccct                      285


<210>  374
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKJ4*02 J-REGION sequence

<400>  374
ctcacgttcg gcggagggac caaggtggag atcaaa                                 36


<210>  375
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized 8H5H5G4 Light chain variable region sequence

<400>  375
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gtgcaagtca gggcattagc aattatttaa actggtatca gcagaaacca      120

gggaaagttc ctaagctcct gatctattac acatcaagtt tacattcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcagcag tatagtaagc ttccttacac gttcggcgga      300

gggaccaagg tggagatcaa acgg                                             324


<210>  376
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized 8H5H5G4 Light chain variable region sequence (codon 
       optimized)

<400>  376
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc       60

atcacatgta gcgccagcca gggcatcagc aactacctga actggtatca gcagaaaccc      120

ggcaaggtgc ccaagctgct gatctactac accagcagcc tgcacagcgg cgtgccaagc      180

agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct      240

gaggacgtgg ccacctacta ctgtcagcag tacagcaagc tgccctacac ctttggcgga      300

ggcaccaagg tggaaatcaa gcgg                                             324


<210>  377
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8H5H5G4 Light chain variable region sequence

<400>  377
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gtgcaagtca gggcattagc aattatttaa actggtatca gcagaaacca      120

gggaaagttc ctaagctcct gatctattac acatcaagtt tacattcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat tacactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcagcag tatagtaagc ttccttacac gttcggcgga      300

gggaccaagg tggagatcaa acgg                                             324


<210>  378
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8H5H5G4 Light chain variable region sequence 
       (codon optimized)

<400>  378
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc       60

atcacatgta gcgccagcca gggcatcagc aactacctga actggtatca gcagaaaccc      120

ggcaaggtgc ccaagctgct gatctactac accagcagcc tgcacagcgg cgtgccaagc      180

agattttctg gcagcggctc tggcaccgac tacaccctga ccatatctag cctgcagcct      240

gaggacgtgg ccacctacta ctgtcagcag tacagcaagc tgccctacac ctttggcgga      300

ggcaccaagg tggaaatcaa gcgg                                             324


<210>  379
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8H5H5G4 scFV sequence (codon optimized)

<400>  379
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg tgtccggaaa taccttcacc gagtacacca tgcactgggt ccgacaggcc      120

cctggcaaag gactggaatg gatcggcggc ttcaacccca acaacggcgt gaccaactac      180

aaccagaaat tcaagggcaa agtgaccctg accgtggaca ccagcagcag cacagcctac      240

atggaactga gcagcctgag aagcgaggac accgccgtgt actactgcgc cagaaggtac      300

taccacagca cctacgtgtt ctacttcgac agctggggcc agggcacact ggtcacagtt      360

tcttctggcg gtggcggaag cggaggcggt ggctccggtg gcggaggcag cgacatccag      420

atgacacaga gccctagcag cctgtctgcc agcgtgggag acagagtgac catcacatgt      480

agcgccagcc agggcatcag caactacctg aactggtatc agcagaaacc cggcaaggtg      540

cccaagctgc tgatctacta caccagcagc ctgcacagcg gcgtgccaag cagattttct      600

ggcagcggct ctggcaccga ctacaccctg accatatcta gcctgcagcc tgaggacgtg      660

gccacctact actgtcagca gtacagcaag ctgccctaca cctttggcgg aggcaccaag      720

gtggaaatca agcgg                                                       735


<210>  380
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region sequence: (for making full
       antibody - pair with either kappa or lambda constant region; 2 
       plasmids, express together)

<400>  380
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgaca gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  381
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG2 heavy chain constant region sequence: (for making full
       antibody - pair with either kappa or lambda constant region; 2 
       plasmids, express together)

<400>  381
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaata g                                                981


<210>  382
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Kappa light chain constant region sequence

<400>  382
aggacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210>  383
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Lambda light chain constant region sequence

<400>  383
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttcata g                                                321


<210>  384
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region sequence: (to be fused to scFv for 
       homo-dimerizes)

<400>  384
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaatga                             699


<210>  385
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region sequence

<400>  385
gagcgcaaat gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc aggaccgtca       60

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      120

acgtgcgtgg tggtggacgt gagccacgaa gaccccgagg tccagttcaa ctggtacgtg      180

gacggcgtgg aggtgcataa tgccaagaca aagccacggg aggagcagtt caacagcacg      240

ttccgtgtgg tcagcgtcct caccgttgtg caccaggact ggctgaacgg caaggagtac      300

aagtgcaagg tctccaacaa aggcctccca gcccccatcg agaaaaccat ctccaaaacc      360

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc      420

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg      480

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacacctcc catgctggac      540

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      600

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      660

agcctctccc tgtctccggg taaatag                                          687


<210>  386
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A4A3 - Heavy chain variable region 
       sequence - H-1,8,9,10,11

<400>  386
gtccagctgc aacagtctgg acctgaactg gtgaagcctg gggcttcagt gaagatatcc       60

tgcaagactt ctggaaacac attcactgaa tacaccatgc actgggtgaa gcagagccat      120

ggaaagagcc ttgagtggat tggaggtttt aatcctaaca atggtgttac taactacaac      180

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      240

gagctccgca gcctgacatc tgaggattct gcagtctatt actgtgcaag acggtactac      300

catagtctct acgtgtttta ctttgactac tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  387
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A4A3 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  387

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Leu Tyr Val Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  388
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A4A3 Heavy chain variable region CDR1

<400>  388

Asn Thr Phe Thr Glu Tyr Thr Met His 
1               5                   


<210>  389
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A4A3 Heavy chain variable region CDR2

<400>  389

Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  390
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A4A3 Heavy chain variable region CDR3

<400>  390

Arg Tyr Tyr His Ser Leu Tyr Val Phe Tyr Phe Asp Tyr 
1               5                   10              


<210>  391
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A4A3 Light chain variable region sequence 
       - K-3,4,9,10,11

<400>  391
gaaacaactg tgacccagtc tccagcatcc ctgtccatgg ctataggaga aaaagtcacc       60

atcagatgca taaccagcac tgatattgat gatgatatga actggtacca gcagaagcca      120

ggggaacctc ctaagctcct tatttcagaa ggcaatactc ttcgtcctgg agtcccatcc      180

cgattctcca gcagtggcta tggtacagat tttgttttta caattgaaaa catgctctca      240

gaagatgttg cagattacta ctgtttgcaa agtgataact tgcctctcac gttcggctcg      300

gggacaaagt tggaaataaa acgg                                             324


<210>  392
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A4A3 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  392

Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Met Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  393
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A4A3 Light chain variable region CDR1

<400>  393

Ile Thr Ser Thr Asp Ile Asp Asp Asp Met Asn 
1               5                   10      


<210>  394
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A4A3 Light chain variable region CDR2

<400>  394

Glu Gly Asn Thr Leu Arg Pro 
1               5           


<210>  395
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A4A3 Light chain variable region CDR3

<400>  395

Leu Gln Ser Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  396
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 - Heavy chain variable region 
       sequence - H-1,4,7,8,12

<400>  396
gtccagctgc aacagtctgg acctgatctg gtgaagcctg ggacttcagt gaagatatcc       60

tgtaagactt ctggaaacac attcactgaa tacaccatgc actgggtgaa gcagagccat      120

ggaaagagcc ttgagtggat tggaggtttt aatcctaaca atggtgttac taactacaac      180

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      240

gagctccgca gcctgacatc tgaggattct gcagtctatt actgtgcaag acgttactac      300

catagtacct acgtgttcta ctttgactcc tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  397
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  397

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  398
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 Heavy chain variable region CDR1

<400>  398

Asn Thr Phe Thr Glu Tyr Thr Met His 
1               5                   


<210>  399
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 Heavy chain variable region CDR2

<400>  399

Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  400
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 Heavy chain variable region CDR3

<400>  400

Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser 
1               5                   10              


<210>  401
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 Light chain variable region sequence
       - K-3,4,5,6,12

<400>  401
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattagc aattatttaa actggtttca gcagaaacca      120

gatggaacta ttaagctcct gatctattac acatcaagtt tacattcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagtaa tgtggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttacac gttcggaggg      300

gggaccaagc tggagataaa acgg                                             324


<210>  402
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 Translated protein

<400>  402

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  403
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  403

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  404
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 Light chain variable region CDR 1

<400>  404

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  405
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 Light chain variable region CDR2

<400>  405

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  406
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E2B11 Light chain variable region CDR3

<400>  406

Gln Gln Tyr Ser Lys Leu Pro Tyr Thr 
1               5                   


<210>  407
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E10E4 - Heavy chain variable region 
       sequence - H-2,4,7,10,12

<400>  407
gtccagctgc aacagtctgg acctgatctg gtgaagcctg ggacttcagt gaagatatcc       60

tgtaagactt ctggaaacac attcactgaa tacaccatgc actgggtgaa gcagagccat      120

ggaaagagcc ttgagtggat tggaggtttt aatcctaaca atggtgttac taactacaac      180

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      240

gagctccgca gcctgacatc tgaggattct gcagtctatt actgtgcaag acgttactac      300

catagtacct acgtgttcta ctttgactcc tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  408
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E10E4 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  408

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  409
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E10E4 Heavy chain variable region CDR1

<400>  409

Asn Thr Phe Thr Glu Tyr Thr Met His 
1               5                   


<210>  410
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E10E4 Heavy chain variable region CDR2

<400>  410

Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  411
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E10E4 Heavy chain variable region CDR3

<400>  411

Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser 
1               5                   10              


<210>  412
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E10E4 Light chain variable region sequence
       - K-2,6,8,14,15

<400>  412
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattagc aattatttaa actggtttca gcagaaacca      120

gatggaacta ttaagctcct gatctattac acatcaagtt tacattcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagtaa tgtggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttacac gttcggaggg      300

gggaccaagc tggagataaa acgg                                             324


<210>  413
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E10E4 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  413

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  414
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E10E4 Light chain variable region CDR 1

<400>  414

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  415
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E10E4 Light chain variable region CDR2

<400>  415

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  416
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9E10E4 Light chain variable region CDR3

<400>  416

Gln Gln Tyr Ser Lys Leu Pro Tyr Thr 
1               5                   


<210>  417
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9G2C4 - Heavy chain variable region 
       sequence - H-4,9,10,11,13

<400>  417
gtccagctgc aacagtctgg acctgatctg gtgaagcctg ggacttcagt gaagatatcc       60

tgtaagactt ctggaaacac attcactgaa tacaccatgc actgggtgaa gcagagccat      120

ggaaagagcc ttgagtggat tggaggtttt aatcctaaca atggtgttac taactacaac      180

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      240

gagctccgca gcctgacatc tgaggattct gcagtctatt actgtgcaag acgttactac      300

catagtacct acgtgttcta ctttgactcc tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  418
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9G2C4 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  418

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  419
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9G2C4 Heavy chain variable region CDR1

<400>  419

Asn Thr Phe Thr Glu Tyr Thr Met His 
1               5                   


<210>  420
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9G2C4 Heavy chain variable region CDR2

<400>  420

Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  421
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9G2C4 Heavy chain variable region CDR3

<400>  421

Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser 
1               5                   10              


<210>  422
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9G2C4 Light chain variable region sequence 
       - K-4,6,7,8,10

<400>  422
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattagc aattatttaa actggtttca gcagaaacca      120

gatggaacta ttaagctcct gatctattac acatcaagtt tacattcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagtaa tgtggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttacac gttcggaggg      300

gggaccaagc tggagataaa acgg                                             324


<210>  423
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9G2C4 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  423

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  424
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9G2C4 Light chain variable region CDR 1

<400>  424

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  425
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9G2C4 Light chain variable region CDR2

<400>  425

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  426
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5D9G2C4 Light chain variable region CDR3

<400>  426

Gln Gln Tyr Ser Lys Leu Pro Tyr Thr 
1               5                   


<210>  427
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5F3A5D4 - Heavy chain variable region 
       sequence - H-2,3,4,13,15

<400>  427
gtccagctgc aacagtctgg acctgatctg gtgaagcctg ggacttcagt gaagatatcc       60

tgtaagactt ctggaaacac attcactgaa tacaccatgc actgggtgaa gcagagccat      120

ggaaagagcc ttgagtggat tggaggtttt aatcctaaca atggtgttac taactacaac      180

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      240

gagctccgca gcctgacatc tgaggattct gcagtctatt actgtgcaag acgttactac      300

catagtacct acgtgttcta ctttgactcc tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  428
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5F3A5D4 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  428

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  429
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5F3A5D4 Heavy chain variable region CDR1

<400>  429

Asn Thr Phe Thr Glu Tyr Thr Met His 
1               5                   


<210>  430
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5F3A5D4 Heavy chain variable region CDR2

<400>  430

Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  431
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5F3A5D4 Heavy chain variable region CDR3

<400>  431

Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser 
1               5                   10              


<210>  432
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5F3A5D4 Light chain variable region sequence 
       - K-1,2,3,4,9

<400>  432
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattagc aattatttaa actggtttca gcagaaacca      120

gatggaacta ttaagctcct gatctattac acatcaagtt tacattcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagtaa tgtggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttacac gttcggaggg      300

gggaccaagc tggagataaa acgg                                             324


<210>  433
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5F3A5D4 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  433

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  434
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5F3A5D4 Light chain variable region CDR1

<400>  434

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  435
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5F3A5D4 Light chain variable region CDR2

<400>  435

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  436
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 5F3A5D4 Light chain variable region CDR3

<400>  436

Gln Gln Tyr Ser Lys Leu Pro Tyr Thr 
1               5                   


<210>  437
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A5A1 - Heavy chain variable region 
       sequence - H-3,4,6,10,11

<400>  437
atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc       60

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      120

ggaaagggtt taaagtggat gggctggata aacacctaca ctggagagcc aacatatgtt      180

gatgacttca agggacggtt tgccttctct ttggaaacct ctgccaccac tgcctatttg      240

cagatcaaca acctcaaaaa tgaggacacg tctacatatt tctgtgcaag attgaggggg      300

atacgaccgg gtcccttggc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  438
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A5A1 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  438

Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly 
            20                  25                  30          


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
        35                  40                  45              


Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe Lys 
    50                  55                  60                  


Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ser Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Leu Arg Gly Ile Arg Pro Gly Pro Leu Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  439
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A5A1 Heavy chain variable region CDR1

<400>  439

Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   


<210>  440
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A5A1 Heavy chain variable region CDR2

<400>  440

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  441
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A5A1 Heavy chain variable region CDR3

<400>  441

Leu Arg Gly Ile Arg Pro Gly Pro Leu Ala Tyr 
1               5                   10      


<210>  442
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A5A1 Light chain variable region sequence 
       - K-1,2,3,4,5

<400>  442
gaaattttgc tcacccagtc tccagcaatc atagctgcat ctcctgggga gaaggtcacc       60

atcacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaaaccagga      120

tcctccccca aaatatggat ttatggtata tccaacctgg cttctggagt tcctgctcgc      180

ttcagtggca gtgggtctgg gacatctttc tctttcacaa tcaacagcat ggaggctgaa      240

gatgttgcca cttattactg tcagcaaagg agtagttacc cacccacgtt cggagggggg      300

accaagctgg aaataaaacg g                                                321


<210>  443
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A5A1 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  443

Glu Ile Leu Leu Thr Gln Ser Pro Ala Ile Ile Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ile Trp Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Phe Ser Phe Thr Ile Asn Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  444
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A5A1 Light chain variable region CDR 1

<400>  444

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  445
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A5A1 Light chain variable region CDR2

<400>  445

Gly Ile Ser Asn Leu Ala Ser 
1               5           


<210>  446
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8F9A5A1 Light chain variable region CDR3

<400>  446

Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  447
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8H5H5G4 - Heavy chain variable region 
       sequence - H-1,3,5,6,10

<400>  447
gtccagctgc aacagtctgg acctgatctg gtgaagcctg ggacttcagt gaagatatcc       60

tgtaagactt ctggaaacac attcactgaa tacaccatgc actgggtgaa gcagagccat      120

ggaaagagcc ttgagtggat tggaggtttt aatcctaaca atggtgttac taactacaac      180

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      240

gagctccgca gcctgacatc tgaggattct gcagtctatt actgtgcaag acgttactac      300

catagtacct acgtgttcta ctttgactcc tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  448
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8H5H5G4 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  448

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  449
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8H5H5G4 Heavy chain variable region CDR1

<400>  449

Asn Thr Phe Thr Glu Tyr Thr Met His 
1               5                   


<210>  450
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8H5H5G4 Heavy chain variable region CDR2

<400>  450

Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  451
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8H5H5G4 Heavy chain variable region CDR3

<400>  451

Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser 
1               5                   10              


<210>  452
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8H5H5G4 Light chain variable region sequence 
       - K-2,5,8,9,15

<400>  452
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattagc aattatttaa actggtttca gcagaaacca      120

gatggaacta ttaagctcct gatctattac acatcaagtt tacattcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagtaa tgtggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttacac gttcggaggg      300

gggaccaagc tggagataaa acgg                                             324


<210>  453
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8H5H5G4 Translated protein, wherein the 
       underlined sequence is the complementarity determining region 
       (CDR)

<400>  453

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  454
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8H5H5G4 Light chain variable region CDR 1

<400>  454

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  455
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8H5H5G4 Light chain variable region CDR2

<400>  455

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  456
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 8H5H5G4 Light chain variable region CDR3

<400>  456

Gln Gln Tyr Ser Lys Leu Pro Tyr Thr 
1               5                   


<210>  457

<400>  457
000

<210>  458

<400>  458
000

<210>  459

<400>  459
000

<210>  460

<400>  460
000

<210>  461

<400>  461
000

<210>  462

<400>  462
000

<210>  463

<400>  463
000

<210>  464

<400>  464
000

<210>  465

<400>  465
000

<210>  466

<400>  466
000

<210>  467

<400>  467
000

<210>  468

<400>  468
000

<210>  469

<400>  469
000

<210>  470

<400>  470
000

<210>  471

<400>  471
000

<210>  472

<400>  472
000

<210>  473

<400>  473
000

<210>  474

<400>  474
000

<210>  475

<400>  475
000

<210>  476

<400>  476
000

<210>  477

<400>  477
000

<210>  478

<400>  478
000

<210>  479

<400>  479
000

<210>  480

<400>  480
000

<210>  481

<400>  481
000

<210>  482

<400>  482
000

<210>  483

<400>  483
000

<210>  484

<400>  484
000

<210>  485

<400>  485
000

<210>  486

<400>  486
000

<210>  487

<400>  487
000

<210>  488

<400>  488
000

<210>  489

<400>  489
000

<210>  490

<400>  490
000

<210>  491

<400>  491
000

<210>  492

<400>  492
000

<210>  493

<400>  493
000

<210>  494

<400>  494
000

<210>  495

<400>  495
000

<210>  496

<400>  496
000

<210>  497

<400>  497
000

<210>  498

<400>  498
000

<210>  499

<400>  499
000

<210>  500

<400>  500
000

<210>  501

<400>  501
000

<210>  502

<400>  502
000

<210>  503

<400>  503
000

<210>  504

<400>  504
000

<210>  505

<400>  505
000

<210>  506

<400>  506
000

<210>  507

<400>  507
000

<210>  508

<400>  508
000

<210>  509

<400>  509
000

<210>  510

<400>  510
000

<210>  511

<400>  511
000

<210>  512

<400>  512
000

<210>  513

<400>  513
000

<210>  514

<400>  514
000

<210>  515

<400>  515
000

<210>  516

<400>  516
000

<210>  517

<400>  517
000

<210>  518

<400>  518
000

<210>  519

<400>  519
000

<210>  520

<400>  520
000

<210>  521

<400>  521
000

<210>  522

<400>  522
000

<210>  523

<400>  523
000

<210>  524

<400>  524
000

<210>  525

<400>  525
000

<210>  526

<400>  526
000

<210>  527

<400>  527
000

<210>  528

<400>  528
000

<210>  529

<400>  529
000

<210>  530

<400>  530
000

<210>  531

<400>  531
000

<210>  532

<400>  532
000

<210>  533

<400>  533
000

<210>  534

<400>  534
000

<210>  535

<400>  535
000

<210>  536

<400>  536
000

<210>  537

<400>  537
000

<210>  538

<400>  538
000

<210>  539

<400>  539
000

<210>  540

<400>  540
000

<210>  541

<400>  541
000

<210>  542

<400>  542
000

<210>  543

<400>  543
000

<210>  544

<400>  544
000

<210>  545

<400>  545
000

<210>  546

<400>  546
000

<210>  547

<400>  547
000

<210>  548

<400>  548
000

<210>  549

<400>  549
000

<210>  550

<400>  550
000

<210>  551

<400>  551
000

<210>  552

<400>  552
000

<210>  553

<400>  553
000

<210>  554

<400>  554
000

<210>  555

<400>  555
000

<210>  556

<400>  556
000

<210>  557

<400>  557
000

<210>  558

<400>  558
000

<210>  559

<400>  559
000

<210>  560

<400>  560
000

<210>  561

<400>  561
000

<210>  562

<400>  562
000

<210>  563

<400>  563
000

<210>  564

<400>  564
000

<210>  565

<400>  565
000

<210>  566

<400>  566
000

<210>  567

<400>  567
000

<210>  568

<400>  568
000

<210>  569

<400>  569
000

<210>  570

<400>  570
000

<210>  571

<400>  571
000

<210>  572

<400>  572
000

<210>  573

<400>  573
000

<210>  574

<400>  574
000

<210>  575

<400>  575
000

<210>  576

<400>  576
000

<210>  577

<400>  577
000

<210>  578

<400>  578
000

<210>  579

<400>  579
000

<210>  580

<400>  580
000

<210>  581

<400>  581
000

<210>  582

<400>  582
000

<210>  583

<400>  583
000

<210>  584

<400>  584
000

<210>  585

<400>  585
000

<210>  586

<400>  586
000

<210>  587

<400>  587
000

<210>  588

<400>  588
000

<210>  589

<400>  589
000

<210>  590

<400>  590
000

<210>  591

<400>  591
000

<210>  592

<400>  592
000

<210>  593

<400>  593
000

<210>  594

<400>  594
000

<210>  595

<400>  595
000

<210>  596

<400>  596
000

<210>  597

<400>  597
000

<210>  598

<400>  598
000

<210>  599

<400>  599
000

<210>  600

<400>  600
000

<210>  601

<400>  601
000

<210>  602

<400>  602
000

<210>  603

<400>  603
000

<210>  604

<400>  604
000

<210>  605

<400>  605
000

<210>  606

<400>  606
000

<210>  607

<400>  607
000

<210>  608

<400>  608
000

<210>  609

<400>  609
000

<210>  610

<400>  610
000

<210>  611

<400>  611
000

<210>  612

<400>  612
000

<210>  613

<400>  613
000

<210>  614

<400>  614
000

<210>  615

<400>  615
000

<210>  616

<400>  616
000

<210>  617

<400>  617
000

<210>  618

<400>  618
000

<210>  619

<400>  619
000

<210>  620

<400>  620
000

<210>  621

<400>  621
000

<210>  622

<400>  622
000

<210>  623

<400>  623
000

<210>  624

<400>  624
000

<210>  625

<400>  625
000

<210>  626

<400>  626
000

<210>  627

<400>  627
000

<210>  628

<400>  628
000

<210>  629

<400>  629
000

<210>  630

<400>  630
000

<210>  631

<400>  631
000

<210>  632

<400>  632
000

<210>  633

<400>  633
000

<210>  634

<400>  634
000

<210>  635

<400>  635
000

<210>  636

<400>  636
000

<210>  637

<400>  637
000

<210>  638

<400>  638
000

<210>  639

<400>  639
000

<210>  640

<400>  640
000

<210>  641

<400>  641
000

<210>  642

<400>  642
000

<210>  643

<400>  643
000

<210>  644

<400>  644
000

<210>  645

<400>  645
000

<210>  646

<400>  646
000

<210>  647

<400>  647
000

<210>  648

<400>  648
000

<210>  649

<400>  649
000

<210>  650

<400>  650
000

<210>  651

<400>  651
000

<210>  652

<400>  652
000

<210>  653

<400>  653
000

<210>  654

<400>  654
000

<210>  655

<400>  655
000

<210>  656

<400>  656
000

<210>  657

<400>  657
000

<210>  658

<400>  658
000

<210>  659

<400>  659
000

<210>  660

<400>  660
000

<210>  661

<400>  661
000

<210>  662

<400>  662
000

<210>  663

<400>  663
000

<210>  664

<400>  664
000

<210>  665

<400>  665
000

<210>  666

<400>  666
000

<210>  667

<400>  667
000

<210>  668

<400>  668
000

<210>  669

<400>  669
000

<210>  670

<400>  670
000

<210>  671

<400>  671
000

<210>  672

<400>  672
000

<210>  673

<400>  673
000

<210>  674

<400>  674
000

<210>  675

<400>  675
000

<210>  676

<400>  676
000

<210>  677

<400>  677
000

<210>  678

<400>  678
000

<210>  679

<400>  679
000

<210>  680

<400>  680
000

<210>  681

<400>  681
000

<210>  682

<400>  682
000

<210>  683

<400>  683
000

<210>  684

<400>  684
000

<210>  685

<400>  685
000

<210>  686

<400>  686
000

<210>  687

<400>  687
000

<210>  688

<400>  688
000

<210>  689

<400>  689
000

<210>  690

<400>  690
000

<210>  691

<400>  691
000

<210>  692

<400>  692
000

<210>  693

<400>  693
000

<210>  694

<400>  694
000

<210>  695

<400>  695
000

<210>  696

<400>  696
000

<210>  697

<400>  697
000

<210>  698

<400>  698
000

<210>  699

<400>  699
000

<210>  700

<400>  700
000

<210>  701

<400>  701
000

<210>  702

<400>  702
000

<210>  703

<400>  703
000

<210>  704

<400>  704
000

<210>  705

<400>  705
000

<210>  706

<400>  706
000

<210>  707

<400>  707
000

<210>  708

<400>  708
000

<210>  709

<400>  709
000

<210>  710

<400>  710
000

<210>  711

<400>  711
000

<210>  712

<400>  712
000

<210>  713

<400>  713
000

<210>  714

<400>  714
000

<210>  715

<400>  715
000

<210>  716

<400>  716
000

<210>  717

<400>  717
000

<210>  718

<400>  718
000

<210>  719

<400>  719
000

<210>  720

<400>  720
000

<210>  721

<400>  721
000

<210>  722

<400>  722
000

<210>  723

<400>  723
000

<210>  724

<400>  724
000

<210>  725

<400>  725
000

<210>  726

<400>  726
000

<210>  727

<400>  727
000

<210>  728

<400>  728
000

<210>  729

<400>  729
000

<210>  730

<400>  730
000

<210>  731

<400>  731
000

<210>  732

<400>  732
000

<210>  733

<400>  733
000

<210>  734

<400>  734
000

<210>  735

<400>  735
000

<210>  736

<400>  736
000

<210>  737

<400>  737
000

<210>  738

<400>  738
000

<210>  739

<400>  739
000

<210>  740

<400>  740
000

<210>  741

<400>  741
000

<210>  742

<400>  742
000

<210>  743

<400>  743
000

<210>  744

<400>  744
000

<210>  745

<400>  745
000

<210>  746

<400>  746
000

<210>  747

<400>  747
000

<210>  748

<400>  748
000

<210>  749

<400>  749
000

<210>  750

<400>  750
000

<210>  751

<400>  751
000

<210>  752

<400>  752
000

<210>  753

<400>  753
000

<210>  754

<400>  754
000

<210>  755

<400>  755
000

<210>  756

<400>  756
000

<210>  757

<400>  757
000

<210>  758

<400>  758
000

<210>  759

<400>  759
000

<210>  760

<400>  760
000

<210>  761

<400>  761
000

<210>  762

<400>  762
000

<210>  763

<400>  763
000

<210>  764

<400>  764
000

<210>  765

<400>  765
000

<210>  766

<400>  766
000

<210>  767

<400>  767
000

<210>  768

<400>  768
000

<210>  769

<400>  769
000

<210>  770

<400>  770
000

<210>  771

<400>  771
000

<210>  772

<400>  772
000

<210>  773

<400>  773
000

<210>  774

<400>  774
000

<210>  775

<400>  775
000

<210>  776

<400>  776
000

<210>  777

<400>  777
000

<210>  778

<400>  778
000

<210>  779

<400>  779
000

<210>  780

<400>  780
000

<210>  781

<400>  781
000

<210>  782

<400>  782
000

<210>  783

<400>  783
000

<210>  784

<400>  784
000

<210>  785

<400>  785
000

<210>  786

<400>  786
000

<210>  787

<400>  787
000

<210>  788

<400>  788
000

<210>  789

<400>  789
000

<210>  790

<400>  790
000

<210>  791

<400>  791
000

<210>  792

<400>  792
000

<210>  793

<400>  793
000

<210>  794

<400>  794
000

<210>  795

<400>  795
000

<210>  796

<400>  796
000

<210>  797

<400>  797
000

<210>  798

<400>  798
000

<210>  799

<400>  799
000

<210>  800

<400>  800
000

<210>  801

<400>  801
000

<210>  802

<400>  802
000

<210>  803

<400>  803
000

<210>  804

<400>  804
000

<210>  805

<400>  805
000

<210>  806

<400>  806
000

<210>  807

<400>  807
000

<210>  808

<400>  808
000

<210>  809

<400>  809
000

<210>  810

<400>  810
000

<210>  811

<400>  811
000

<210>  812

<400>  812
000

<210>  813

<400>  813
000

<210>  814

<400>  814
000

<210>  815

<400>  815
000

<210>  816

<400>  816
000

<210>  817

<400>  817
000

<210>  818

<400>  818
000

<210>  819

<400>  819
000

<210>  820

<400>  820
000

<210>  821

<400>  821
000

<210>  822

<400>  822
000

<210>  823

<400>  823
000

<210>  824

<400>  824
000

<210>  825

<400>  825
000

<210>  826

<400>  826
000

<210>  827

<400>  827
000

<210>  828

<400>  828
000

<210>  829

<400>  829
000

<210>  830

<400>  830
000

<210>  831

<400>  831
000

<210>  832

<400>  832
000

<210>  833

<400>  833
000

<210>  834

<400>  834
000

<210>  835

<400>  835
000

<210>  836

<400>  836
000

<210>  837

<400>  837
000

<210>  838

<400>  838
000

<210>  839

<400>  839
000

<210>  840

<400>  840
000

<210>  841

<400>  841
000

<210>  842

<400>  842
000

<210>  843

<400>  843
000

<210>  844

<400>  844
000

<210>  845

<400>  845
000

<210>  846

<400>  846
000

<210>  847

<400>  847
000

<210>  848

<400>  848
000

<210>  849

<400>  849
000

<210>  850

<400>  850
000

<210>  851

<400>  851
000

<210>  852

<400>  852
000

<210>  853

<400>  853
000

<210>  854

<400>  854
000

<210>  855

<400>  855
000

<210>  856

<400>  856
000

<210>  857

<400>  857
000

<210>  858

<400>  858
000

<210>  859

<400>  859
000

<210>  860

<400>  860
000

<210>  861

<400>  861
000

<210>  862

<400>  862
000

<210>  863

<400>  863
000

<210>  864

<400>  864
000

<210>  865

<400>  865
000

<210>  866

<400>  866
000

<210>  867

<400>  867
000

<210>  868

<400>  868
000

<210>  869

<400>  869
000

<210>  870

<400>  870
000

<210>  871

<400>  871
000

<210>  872

<400>  872
000

<210>  873

<400>  873
000

<210>  874

<400>  874
000

<210>  875

<400>  875
000

<210>  876

<400>  876
000

<210>  877

<400>  877
000

<210>  878

<400>  878
000

<210>  879

<400>  879
000

<210>  880

<400>  880
000

<210>  881

<400>  881
000

<210>  882

<400>  882
000

<210>  883

<400>  883
000

<210>  884

<400>  884
000

<210>  885

<400>  885
000

<210>  886

<400>  886
000

<210>  887

<400>  887
000

<210>  888

<400>  888
000

<210>  889

<400>  889
000

<210>  890

<400>  890
000

<210>  891

<400>  891
000

<210>  892

<400>  892
000

<210>  893

<400>  893
000

<210>  894

<400>  894
000

<210>  895

<400>  895
000

<210>  896

<400>  896
000

<210>  897

<400>  897
000

<210>  898

<400>  898
000

<210>  899

<400>  899
000

<210>  900

<400>  900
000

<210>  901

<400>  901
000

<210>  902

<400>  902
000

<210>  903

<400>  903
000

<210>  904

<400>  904
000

<210>  905

<400>  905
000

<210>  906

<400>  906
000

<210>  907

<400>  907
000

<210>  908

<400>  908
000

<210>  909

<400>  909
000

<210>  910

<400>  910
000

<210>  911

<400>  911
000

<210>  912

<400>  912
000

<210>  913

<400>  913
000

<210>  914

<400>  914
000

<210>  915

<400>  915
000

<210>  916

<400>  916
000

<210>  917

<400>  917
000

<210>  918

<400>  918
000

<210>  919

<400>  919
000

<210>  920

<400>  920
000

<210>  921

<400>  921
000

<210>  922

<400>  922
000

<210>  923

<400>  923
000

<210>  924

<400>  924
000

<210>  925

<400>  925
000

<210>  926

<400>  926
000

<210>  927

<400>  927
000

<210>  928

<400>  928
000

<210>  929

<400>  929
000

<210>  930

<400>  930
000

<210>  931

<400>  931
000

<210>  932

<400>  932
000

<210>  933

<400>  933
000

<210>  934

<400>  934
000

<210>  935

<400>  935
000

<210>  936

<400>  936
000

<210>  937

<400>  937
000

<210>  938

<400>  938
000

<210>  939

<400>  939
000

<210>  940

<400>  940
000

<210>  941

<400>  941
000

<210>  942

<400>  942
000

<210>  943

<400>  943
000

<210>  944

<400>  944
000

<210>  945

<400>  945
000

<210>  946

<400>  946
000

<210>  947

<400>  947
000

<210>  948

<400>  948
000

<210>  949

<400>  949
000

<210>  950

<400>  950
000

<210>  951

<400>  951
000

<210>  952

<400>  952
000

<210>  953

<400>  953
000

<210>  954

<400>  954
000

<210>  955

<400>  955
000

<210>  956

<400>  956
000

<210>  957

<400>  957
000

<210>  958

<400>  958
000

<210>  959

<400>  959
000

<210>  960

<400>  960
000

<210>  961

<400>  961
000

<210>  962

<400>  962
000

<210>  963

<400>  963
000

<210>  964

<400>  964
000

<210>  965

<400>  965
000

<210>  966

<400>  966
000

<210>  967

<400>  967
000

<210>  968

<400>  968
000

<210>  969

<400>  969
000

<210>  970

<400>  970
000

<210>  971

<400>  971
000

<210>  972

<400>  972
000

<210>  973

<400>  973
000

<210>  974

<400>  974
000

<210>  975

<400>  975
000

<210>  976

<400>  976
000

<210>  977

<400>  977
000

<210>  978

<400>  978
000

<210>  979

<400>  979
000

<210>  980

<400>  980
000

<210>  981

<400>  981
000

<210>  982

<400>  982
000

<210>  983

<400>  983
000

<210>  984

<400>  984
000

<210>  985

<400>  985
000

<210>  986

<400>  986
000

<210>  987

<400>  987
000

<210>  988

<400>  988
000

<210>  989

<400>  989
000

<210>  990

<400>  990
000

<210>  991

<400>  991
000

<210>  992

<400>  992
000

<210>  993

<400>  993
000

<210>  994

<400>  994
000

<210>  995

<400>  995
000

<210>  996

<400>  996
000

<210>  997

<400>  997
000

<210>  998

<400>  998
000

<210>  999

<400>  999
000

<210>  1000

<400>  1000
000

<210>  1001
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-NME7 B3 peptide monoclonal antibodies - 8F9A4A3 Heavy chain 
       variable region sequence mouse

<400>  1001

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Leu Tyr Val Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  1002
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV1-24*01 V-REGION sequence human (closest match hu antibody 
       sequence)

<400>  1002

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr 
        


<210>  1003
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHJ4*01 J-REGION sequence human (closest match hu antibody 
       sequence)

<400>  1003

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  1004
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A4A3 Heavy chain variable region sequence

<400>  1004

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asn Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr His Ser Leu Tyr Val Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1005
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A4A3 Heavy chain variable region sequence (codon 
       optimized)

<400>  1005

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asn Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr His Ser Leu Tyr Val Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1006
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A4A3 Heavy chain variable region sequence)

<400>  1006

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asn Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr His Ser Leu Tyr Val Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1007
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A4A3 Heavy chain variable region sequence 
       (codon optimized)

<400>  1007

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asn Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr His Ser Leu Tyr Val Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1008
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F9A4A3 Light chain variable region sequence mouse

<400>  1008

Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Met Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  1009
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV5-2*01 V-REGION sequence human (closest match hu antibody 
       sequence)

<400>  1009

Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Asp Lys Val Asn Ile Ser Cys Lys Ala Ser Gln Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Phe Ile Ile 
        35                  40                  45              


Gln Glu Ala Thr Thr Leu Val Pro Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys 
                85              


<210>  1010
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKJ4*02 J-REGION sequence human (closest match hu antibody 
       sequence)

<400>  1010

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  1011
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A4A3 Light chain variable region sequence

<400>  1011

Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Asp Lys Val Asn Ile Ser Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Phe Ile Ile 
        35                  40                  45              


Gln Glu Gly Asn Thr Leu Arg Pro Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  1012
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A4A3 Light chain variable region sequence (codon 
       optimized)

<400>  1012

Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Asp Lys Val Asn Ile Ser Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Phe Ile Ile 
        35                  40                  45              


Gln Glu Gly Asn Thr Leu Arg Pro Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  1013
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A4A3 Light chain variable region sequence

<400>  1013

Glu Thr Thr Val Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Ser Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Ile Pro Pro Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  1014
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A4A3 Light chain variable region sequence 
       (codon optimized)

<400>  1014

Glu Thr Thr Val Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Ser Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Ile Pro Pro Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  1015
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A4A3 sequence (codon optimized) - humanized
       heavy and light chains joined via a flexible linker

<400>  1015

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asn Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr His Ser Leu Tyr Val Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Thr Thr Val Thr Gln Ser 
    130                 135                 140                 


Pro Ala Phe Met Ser Ala Thr Pro Gly Asp Lys Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ile Thr Ser Thr Asp Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Glu Ala Ala Ile Leu Leu Ile Ser Glu Gly Asn Thr Leu Arg 
            180                 185                 190         


Pro Gly Ile Pro Pro Arg Phe Ser Ser Ser Gly Tyr Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Asn Asn Ile Glu Ser Glu Asp Ala Ala Tyr Tyr Phe 
    210                 215                 220                 


Cys Leu Gln Ser Asp Asn Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Arg 
                245 


<210>  1016
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F9A5A1 Heavy chain variable region sequence

<400>  1016

Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly 
            20                  25                  30          


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
        35                  40                  45              


Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe Lys 
    50                  55                  60                  


Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ser Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Leu Arg Gly Ile Arg Pro Gly Pro Leu Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  1017
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV7-81*01 V-REGION sequence

<400>  1017

Gln Val Gln Leu Val Gln Ser Gly His Glu Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Pro Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Phe Asn Thr Tyr Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Met Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Met Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  1018
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHJ4*03 J-REGION sequence

<400>  1018

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  1019
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A5A1 Heavy chain variable region sequence

<400>  1019

Gln Val Gln Leu Val Gln Ser Gly His Glu Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Pro Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Met Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Met Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Gly Ile Arg Pro Gly Pro Leu Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1020
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A5A1 Heavy chain variable region sequence (codon 
       optimized)

<400>  1020

Gln Val Gln Leu Val Gln Ser Gly His Glu Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Pro Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Met Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Met Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Gly Ile Arg Pro Gly Pro Leu Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1021
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A5A1 Heavy chain variable region sequence

<400>  1021

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Met Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Gly Ile Arg Pro Gly Pro Leu Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1022
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A5A1 Heavy chain variable region sequence 
       (codon optimized)

<400>  1022

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Met Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Gly Ile Arg Pro Gly Pro Leu Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1023
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F9A5A1 Light chain variable region sequence

<400>  1023

Glu Ile Leu Leu Thr Gln Ser Pro Ala Ile Ile Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ile Trp Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Phe Ser Phe Thr Ile Asn Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  1024
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV3D-15*02 V-REGION sequence

<400>  1024

Glu Ile Val Met Met Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn 
                85                  90              


<210>  1025
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKJ4*02 J-REGION sequence

<400>  1025

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  1026
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A5A1 Light chain variable region sequence

<400>  1026

Glu Ile Val Met Met Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  1027
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 8F9A5A1 Light chain variable region sequence (codon 
       optimized)

<400>  1027

Glu Ile Val Met Met Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  1028
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A5A1 Light chain variable region sequence

<400>  1028

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile Ser Ser Leu Gln Ser Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  1029
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A5A1 Light chain variable region sequence 
       (codon optimized)

<400>  1029

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile Ser Ser Leu Gln Ser Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  1030
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8F9A5A1 scFV sequence (codon optimized)

<400>  1030

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Met Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Gly Ile Arg Pro Gly Pro Leu Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Arg Leu Trp Ile Tyr Gly Ile Ser Asn Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Arg Ser Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  1031
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H5H5G4 Heavy chain variable region sequence

<400>  1031

Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Glu Tyr Thr 
            20                  25                  30          


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  1032
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV1-24*01 V-REGION sequence

<400>  1032

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr 
        


<210>  1033
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHJ4*03 J-REGION sequence

<400>  1033

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  1034
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 8H5H5G4 Heavy chain variable region sequence

<400>  1034

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asn Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1035
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 8H5H5G4 Heavy chain variable region sequence (codon 
       optimized)

<400>  1035

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asn Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1036
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Humanized 8H5H5G4 Heavy chain variable region sequence

<400>  1036

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asn Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1037
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Humanized 8H5H5G4 Heavy chain variable region sequence 
       (codon optimized)

<400>  1037

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asn Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1038
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H5H5G4 Light chain variable region sequence

<400>  1038

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  1039
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV1-27*01 V-REGION sequence

<400>  1039

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro 
                85                  90                  95  


<210>  1040
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKJ4*02 J-REGION sequence

<400>  1040

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  1041
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 8H5H5G4 Light chain variable region sequence

<400>  1041

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  1042
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 8H5H5G4 Light chain variable region sequence (codon 
       optimized)

<400>  1042

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  1043
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8H5H5G4 Light chain variable region sequence

<400>  1043

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  1044
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8H5H5G4 Light chain variable region sequence 
       (codon optimized)

<400>  1044

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  1045
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified humanized 8H5H5G4 scFV sequence (codon optimized)

<400>  1045

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asn Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Phe Asn Pro Asn Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr His Ser Thr Tyr Val Phe Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Ser Leu His 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Ser Lys Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Arg 
                245 


<210>  1046
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region sequence: (for making full
       antibody -  pair with either kappa or lambda constant region; 2 
       plasmids, express together)

<400>  1046

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1047
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 heavy chain constant region sequence: (for making full
       antibody - pair with either kappa or lambda constant region; 2 
       plasmids, express together)

<400>  1047

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  1048
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Kappa light chain constant region sequence

<400>  1048

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  1049
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lambda light chain constant region sequence

<400>  1049

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  1050
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region sequence: (to be fused to scFv for 
       homo-dimerizes)

<400>  1050

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  1051
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region sequence

<400>  1051

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


